
                                SEQUENCE LISTING

<110> Seattle Children's Hospital dba Seattle Children's Research Institute
      Scharenberg, Andrew

<120> METHODS OF EXOGENOUS DRUG ACTIVATION OF
  CHEMICAL-INDUCED SIGNALING COMPLEXES EXPRESSED IN ENGINEERED
  CELLS IN VITRO AND IN VIVO

<130> SCRI.130WO

<140> PCT/US2017/065746
<141> 2017-12-12

<150> 62/433540
<151> 2016-12-13

<160> 20

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 251
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL2R-CISC - gamma component

<400> 1
Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu
 1               5                  10                  15      
His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly
            20                  25                  30          
Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly
        35                  40                  45              
Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys
    50                  55                  60                  
Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu
65                  70                  75                  80  
Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile
                85                  90                  95      
Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro
            100                 105                 110         
Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Gly Glu
        115                 120                 125             
Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe Ala Leu Glu Ala
    130                 135                 140                 
Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys
145                 150                 155                 160 
Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys
                165                 170                 175     
Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp
            180                 185                 190         
Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser
        195                 200                 205             
Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu
    210                 215                 220                 
Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp
225                 230                 235                 240 
Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr
                245                 250     


<210> 2
<211> 429
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL2R-CISC - beta component

<400> 2
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Ile Leu Trp His Glu Met Trp His Glu Gly Leu
            20                  25                  30          
Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met
        35                  40                  45              
Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln
    50                  55                  60                  
Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met
65                  70                  75                  80  
Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys
                85                  90                  95      
Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile
            100                 105                 110         
Ser Lys Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly
        115                 120                 125             
Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn
    130                 135                 140                 
Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr
145                 150                 155                 160 
Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly
                165                 170                 175     
Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser
            180                 185                 190         
Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg
        195                 200                 205             
Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro
    210                 215                 220                 
Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln
225                 230                 235                 240 
Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys
                245                 250                 255     
Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu
            260                 265                 270         
Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro
        275                 280                 285             
Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp
    290                 295                 300                 
Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser
305                 310                 315                 320 
Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser
                325                 330                 335     
Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro
            340                 345                 350         
Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu
        355                 360                 365             
Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg
    370                 375                 380                 
Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe
385                 390                 395                 400 
Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser
                405                 410                 415     
Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val
            420                 425                 


<210> 3
<211> 352
<212> PRT
<213> Artificial Sequence

<220> 
<223> FKBP IL2Rg CISC 1210

<400> 3
Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu
 1               5                  10                  15      
His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly
            20                  25                  30          
Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly
        35                  40                  45              
Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys
    50                  55                  60                  
Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu
65                  70                  75                  80  
Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile
                85                  90                  95      
Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro
            100                 105                 110         
Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly
        115                 120                 125             
Gly Gly Ser Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu Thr
    130                 135                 140                 
Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn Arg
145                 150                 155                 160 
Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp Trp
                165                 170                 175     
Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe Ser
            180                 185                 190         
Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg Ser
        195                 200                 205             
Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp Ser
    210                 215                 220                 
His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu
225                 230                 235                 240 
Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu Ile
                245                 250                 255     
Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg
            260                 265                 270         
Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly
        275                 280                 285             
Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu
    290                 295                 300                 
Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro
305                 310                 315                 320 
Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln
                325                 330                 335     
His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr
            340                 345                 350         


<210> 4
<211> 544
<212> PRT
<213> Artificial Sequence

<220> 
<223> FRB IL2Rb CISC 1210

<400> 4
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Ile Leu Trp His Glu Met Trp His Glu Gly Leu
            20                  25                  30          
Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met
        35                  40                  45              
Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln
    50                  55                  60                  
Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met
65                  70                  75                  80  
Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys
                85                  90                  95      
Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile
            100                 105                 110         
Ser Lys Gly Gly Ser Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro
        115                 120                 125             
Ile Ser Leu Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser
    130                 135                 140                 
Trp Glu Ile Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe
145                 150                 155                 160 
Glu Ala Arg Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu
                165                 170                 175     
Leu Thr Leu Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr
            180                 185                 190         
Pro Asp Thr Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly
        195                 200                 205             
Glu Phe Thr Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr
    210                 215                 220                 
Lys Pro Ala Ala Leu Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu
225                 230                 235                 240 
Leu Val Gly Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu
                245                 250                 255     
Leu Ile Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys
            260                 265                 270         
Cys Asn Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu
        275                 280                 285             
His Gly Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser
    290                 295                 300                 
Ser Phe Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val
305                 310                 315                 320 
Leu Glu Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val
                325                 330                 335     
Pro Glu Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe
            340                 345                 350         
Thr Asn Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile
        355                 360                 365             
Glu Ala Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp
    370                 375                 380                 
Pro Asp Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro
385                 390                 395                 400 
Leu Gln Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser
                405                 410                 415     
Arg Asp Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser
            420                 425                 430         
Pro Pro Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met
        435                 440                 445             
Pro Pro Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro
    450                 455                 460                 
Leu Gly Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro
465                 470                 475                 480 
Pro Pro Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala
                485                 490                 495     
Gly Pro Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln
            500                 505                 510         
Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala
        515                 520                 525             
Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val
    530                 535                 540                 


<210> 5
<211> 349
<212> PRT
<213> Artificial Sequence

<220> 
<223> FKBP IL2Rg CISC 1211

<400> 5
Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu
 1               5                  10                  15      
His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly
            20                  25                  30          
Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly
        35                  40                  45              
Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys
    50                  55                  60                  
Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu
65                  70                  75                  80  
Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile
                85                  90                  95      
Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro
            100                 105                 110         
Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly
        115                 120                 125             
Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu Thr Leu His Lys
    130                 135                 140                 
Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn Arg Phe Leu Asn
145                 150                 155                 160 
His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp Trp Asp His Ser
                165                 170                 175     
Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe Ser Leu Pro Ser
            180                 185                 190         
Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg Ser Arg Phe Asn
        195                 200                 205             
Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp Ser His Pro Ile
    210                 215                 220                 
His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe Ala Leu
225                 230                 235                 240 
Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu
                245                 250                 255     
Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr
            260                 265                 270         
Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser
        275                 280                 285             
Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp
    290                 295                 300                 
Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly
305                 310                 315                 320 
Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro
                325                 330                 335     
Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr
            340                 345                 


<210> 6
<211> 541
<212> PRT
<213> Artificial Sequence

<220> 
<223> FRB IL2Rb CISC 1211

<400> 6
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Ile Leu Trp His Glu Met Trp His Glu Gly Leu
            20                  25                  30          
Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met
        35                  40                  45              
Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln
    50                  55                  60                  
Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met
65                  70                  75                  80  
Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys
                85                  90                  95      
Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile
            100                 105                 110         
Ser Lys Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu
        115                 120                 125             
Gln Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile
    130                 135                 140                 
Ser Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg
145                 150                 155                 160 
Thr Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu
                165                 170                 175     
Lys Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr
            180                 185                 190         
Gln Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr
        195                 200                 205             
Thr Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala
    210                 215                 220                 
Ala Leu Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly
225                 230                 235                 240 
Leu Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn
                245                 250                 255     
Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr
            260                 265                 270         
Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly
        275                 280                 285             
Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser
    290                 295                 300                 
Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg
305                 310                 315                 320 
Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro
                325                 330                 335     
Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln
            340                 345                 350         
Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys
        355                 360                 365             
Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu
    370                 375                 380                 
Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro
385                 390                 395                 400 
Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp
                405                 410                 415     
Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser
            420                 425                 430         
Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser
        435                 440                 445             
Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro
    450                 455                 460                 
Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu
465                 470                 475                 480 
Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg
                485                 490                 495     
Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe
            500                 505                 510         
Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser
        515                 520                 525             
Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val
    530                 535                 540     


<210> 7
<211> 251
<212> PRT
<213> Artificial Sequence

<220> 
<223> FKBP IL2Rg CISC 1233

<400> 7
Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu
 1               5                  10                  15      
His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly
            20                  25                  30          
Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly
        35                  40                  45              
Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys
    50                  55                  60                  
Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu
65                  70                  75                  80  
Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile
                85                  90                  95      
Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro
            100                 105                 110         
Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly
        115                 120                 125             
Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe Ala Leu Glu Ala
    130                 135                 140                 
Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys
145                 150                 155                 160 
Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys
                165                 170                 175     
Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp
            180                 185                 190         
Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser
        195                 200                 205             
Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu
    210                 215                 220                 
Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp
225                 230                 235                 240 
Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr
                245                 250     


<210> 8
<211> 379
<212> PRT
<213> Artificial Sequence

<220> 
<223> FRB IL2Rb CISC 1233

<400> 8
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Ile Leu Trp His Glu Met Trp His Glu Gly Leu
            20                  25                  30          
Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met
        35                  40                  45              
Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln
    50                  55                  60                  
Thr Leu Lys Glu Thr Ser Trp Leu Gly His Leu Leu Val Gly Leu Ser
65                  70                  75                  80  
Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg
                85                  90                  95      
Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp
            100                 105                 110         
Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val
        115                 120                 125             
Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly
    130                 135                 140                 
Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys
145                 150                 155                 160 
Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser
                165                 170                 175     
Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr
            180                 185                 190         
Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val
        195                 200                 205             
Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val
    210                 215                 220                 
Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser
225                 230                 235                 240 
Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu
                245                 250                 255     
Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala
            260                 265                 270         
Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln
        275                 280                 285             
Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr
    290                 295                 300                 
Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val
305                 310                 315                 320 
Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly
                325                 330                 335     
Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala
            340                 345                 350         
Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln
        355                 360                 365             
Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val
    370                 375                 


<210> 9
<211> 345
<212> PRT
<213> Artificial Sequence

<220> 
<223> FRB IL7Ra CISC

<400> 9
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1               5                  10                  15      
His Ala Ala Arg Pro Ile Leu Trp His Glu Met Trp His Glu Gly Leu
            20                  25                  30          
Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met
        35                  40                  45              
Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln
    50                  55                  60                  
Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met
65                  70                  75                  80  
Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys
                85                  90                  95      
Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile
            100                 105                 110         
Ser Lys Gly Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro Ile Leu
        115                 120                 125             
Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu Val Ile
    130                 135                 140                 
Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val Trp Pro
145                 150                 155                 160 
Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro
                165                 170                 175     
Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys
            180                 185                 190         
Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly
        195                 200                 205             
Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln
    210                 215                 220                 
Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val
225                 230                 235                 240 
Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu
                245                 250                 255     
Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg
            260                 265                 270         
Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln
        275                 280                 285             
Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro
    290                 295                 300                 
Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly
305                 310                 315                 320 
Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val
                325                 330                 335     
Thr Met Ser Ser Phe Tyr Gln Asn Gln
            340                 345 


<210> 10
<211> 443
<212> PRT
<213> Artificial Sequence

<220> 
<223> FKBP-F36V IL2Rb CISC

<400> 10
Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu
 1               5                  10                  15      
His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly
            20                  25                  30          
Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly
        35                  40                  45              
Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys
    50                  55                  60                  
Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu
65                  70                  75                  80  
Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile
                85                  90                  95      
Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro
            100                 105                 110         
Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly
        115                 120                 125             
Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser
    130                 135                 140                 
Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg
145                 150                 155                 160 
Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp
                165                 170                 175     
Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val
            180                 185                 190         
Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly
        195                 200                 205             
Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys
    210                 215                 220                 
Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser
225                 230                 235                 240 
Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr
                245                 250                 255     
Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val
            260                 265                 270         
Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val
        275                 280                 285             
Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser
    290                 295                 300                 
Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu
305                 310                 315                 320 
Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala
                325                 330                 335     
Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln
            340                 345                 350         
Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr
        355                 360                 365             
Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val
    370                 375                 380                 
Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly
385                 390                 395                 400 
Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala
                405                 410                 415     
Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln
            420                 425                 430         
Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val
        435                 440             


<210> 11
<211> 251
<212> PRT
<213> Artificial Sequence

<220> 
<223> FKBP-F36V IL2Rg CISC 1233

<400> 11
Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu
 1               5                  10                  15      
His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly
            20                  25                  30          
Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly
        35                  40                  45              
Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys
    50                  55                  60                  
Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu
65                  70                  75                  80  
Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile
                85                  90                  95      
Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro
            100                 105                 110         
Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly
        115                 120                 125             
Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe Ala Leu Glu Ala
    130                 135                 140                 
Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys
145                 150                 155                 160 
Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys
                165                 170                 175     
Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp
            180                 185                 190         
Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser
        195                 200                 205             
Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu
    210                 215                 220                 
Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp
225                 230                 235                 240 
Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr
                245                 250     


<210> 12
<211> 358
<212> PRT
<213> Artificial Sequence

<220> 
<223> FKBP-F36V IL7Ra CISC 1

<400> 12
Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu
 1               5                  10                  15      
His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly
            20                  25                  30          
Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly
        35                  40                  45              
Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys
    50                  55                  60                  
Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu
65                  70                  75                  80  
Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile
                85                  90                  95      
Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro
            100                 105                 110         
Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly
        115                 120                 125             
Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro Ile Leu Leu Thr Ile
    130                 135                 140                 
Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu Val Ile Leu Ala Cys
145                 150                 155                 160 
Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro
                165                 170                 175     
Asp His Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn
            180                 185                 190         
Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His
        195                 200                 205             
Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln
    210                 215                 220                 
Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly
225                 230                 235                 240 
Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr
                245                 250                 255     
Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn
            260                 265                 270         
Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp
        275                 280                 285             
Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu
    290                 295                 300                 
Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu
305                 310                 315                 320 
Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile
                325                 330                 335     
Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser
            340                 345                 350         
Ser Phe Tyr Gln Asn Gln
        355             


<210> 13
<211> 358
<212> PRT
<213> Artificial Sequence

<220> 
<223> FKBP-F36V IL7Ra CISC 2

<400> 13
Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu
 1               5                  10                  15      
His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly
            20                  25                  30          
Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly
        35                  40                  45              
Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys
    50                  55                  60                  
Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu
65                  70                  75                  80  
Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile
                85                  90                  95      
Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro
            100                 105                 110         
Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly
        115                 120                 125             
Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro Ile Leu Leu Thr Ile
    130                 135                 140                 
Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu Val Ile Leu Ala Cys
145                 150                 155                 160 
Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val Trp Pro Ser Leu Pro
                165                 170                 175     
Asp His Lys Lys Thr Leu Glu His Leu Cys Lys Lys Pro Arg Lys Asn
            180                 185                 190         
Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu Asp Cys Gln Ile His
        195                 200                 205             
Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val Glu Gly Phe Leu Gln
    210                 215                 220                 
Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu Lys Gln Arg Leu Gly
225                 230                 235                 240 
Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu Asp Val Val Ile Thr
                245                 250                 255     
Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr Cys Leu Ala Gly Asn
            260                 265                 270         
Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser Ser Arg Ser Leu Asp
        275                 280                 285             
Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu
    290                 295                 300                 
Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu
305                 310                 315                 320 
Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile
                325                 330                 335     
Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser
            340                 345                 350         
Ser Phe Tyr Gln Asn Gln
        355             


<210> 14
<211> 276
<212> PRT
<213> Artificial Sequence

<220> 
<223> FKBP-F36V MPL

<400> 14
Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu
 1               5                  10                  15      
His Ala Gln Ala Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly
            20                  25                  30          
Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly
        35                  40                  45              
Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys
    50                  55                  60                  
Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu
65                  70                  75                  80  
Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile
                85                  90                  95      
Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro
            100                 105                 110         
Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Gly Glu
        115                 120                 125             
Glu Thr Ala Trp Ile Ser Leu Val Thr Ala Leu His Leu Val Leu Gly
    130                 135                 140                 
Leu Ser Ala Val Leu Gly Leu Leu Leu Leu Arg Trp Gln Phe Pro Ala
145                 150                 155                 160 
His Tyr Arg Arg Leu Arg His Ala Leu Trp Pro Ser Leu Pro Asp Leu
                165                 170                 175     
His Arg Val Leu Gly Gln Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro
            180                 185                 190         
Pro Lys Ala Thr Val Ser Asp Thr Cys Glu Glu Val Glu Pro Ser Leu
        195                 200                 205             
Leu Glu Ile Leu Pro Lys Ser Ser Glu Arg Thr Pro Leu Pro Leu Cys
    210                 215                 220                 
Ser Ser Gln Ala Gln Met Asp Tyr Arg Arg Leu Gln Pro Ser Cys Leu
225                 230                 235                 240 
Gly Thr Met Pro Leu Ser Val Cys Pro Pro Met Ala Glu Ser Gly Ser
                245                 250                 255     
Cys Cys Thr Thr His Ile Ala Asn His Ser Tyr Leu Pro Leu Ser Tyr
            260                 265                 270         
Trp Gln Gln Pro
        275     


<210> 15
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycine spacer 1

<400> 15
Gly Gly Gly Ser
 1              


<210> 16
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycine spacer 2

<400> 16
Gly Gly Gly Ser Gly Gly Gly
 1               5          


<210> 17
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Glycine spacer 3

<400> 17
Gly Gly Gly
 1          


<210> 18
<211> 10035
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL2Rg upstream of IL2Rb

<400> 18
agcttaatgt agtcttatgc aatactcttg tagtcttgca acatggtaac gatgagttag 60
caacatgcct tacaaggaga gaaaaagcac cgtgcatgcc gattggtgga agtaaggtgg 120
tacgatcgtg ccttattagg aaggcaacag acgggtctga catggattgg acgaaccact 180
gaattgccgc attgcagaga tattgtattt aagtgcctag ctcgatacaa taaacgggtc 240
tctctggtta gaccagatct gagcctggga gctctctggc taactaggga acccactgct 300
taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga 360
ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtgg 420
cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg agctctctcg acgcaggact 480
cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa 540
attttgacta gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg 600
gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat 660
aaattaaaac atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc 720
ctgttagaaa catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag 780
acaggatcag aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat 840
caaaggatag agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac 900
aaaagtaaga ccaccgcaca gcaagcggcc gctgatcttc agacctggag gaggagatat 960
gagggacaat tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg 1020
agtagcaccc accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat 1080
aggagctttg ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcctcaat 1140
gacgctgacg gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt 1200
gctgagggct attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca 1260
gctccaggca agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat 1320
ttggggttgc tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag 1380
taataaatct ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat 1440
taacaattac acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa 1500
gaatgaacaa gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat 1560
aacaaattgg ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt 1620
aagaatagtt tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt 1680
atcgtttcag acccacctcc caaccccgag gggacccgac aggcccgaag gaatagaaga 1740
agaaggtgga gagagagaca gagacagatc cattcgatta gtgaacggat ctcgacggta 1800
tcggttaact tttaaaagaa aaggggggat tggggggtac agtgcagggg aaagaatagt 1860
agacataata gcaacagaca tacaaactaa agaattacaa aaacaaatta caaaaattca 1920
aaattttatc gatcacgaga ctagcctcga gaagcttgat atcgaattcc cacggggttg 1980
gacgcgtagg aacagagaaa caggagaata tgggccaaac aggatatctg tggtaagcag 2040
ttcctgcccc ggctcagggc caagaacagt tggaacagca gaatatgggc caaacaggat 2100
atctgtggta agcagttcct gccccggctc agggccaaga acagatggtc cccagatgcg 2160
gtcccgccct cagcagtttc tagagaacca tcagatgttt ccagggtgcc ccaaggacct 2220
gaaatgaccc tgtgccttat ttgaactaac caatcagttc gcttctcgct tctgttcgcg 2280
cgcttctgct ccccgagctc tatataagca gagctcgttt agtgaaccgt cagatcgcta 2340
gcaccggtgc cgccaccatg cctctgggcc tgctgtggct gggcctggcc ctgctgggcg 2400
ccctgcacgc ccaggccggc gtgcaggtgg agacaatctc cccaggcgac ggacgcacat 2460
tccctaagcg gggccagacc tgcgtggtgc actatacagg catgctggag gatggcaaga 2520
agtttgacag ctcccgggat agaaacaagc cattcaagtt tatgctgggc aagcaggaag 2580
tgatcagagg ctgggaggag ggcgtggccc agatgtctgt gggccagagg gccaagctga 2640
ccatcagccc agactacgcc tatggagcaa caggccaccc aggaatcatc ccacctcacg 2700
ccaccctggt gttcgatgtg gagctgctga agctgggcga gcaaaacttg gtgattcctt 2760
gggccccaga aaatctcacg cttcacaagt tgtccgaatc ccagctcgag ctcaactgga 2820
ataatagatt tcttaatcat tgtttggaac acctggttca atatagaacg gattgggacc 2880
actcatggac cgagcagtca gttgactacc gccacaaatt ttcacttccc agcgtagatg 2940
ggcagaagag gtacacattt agggtcagat ccaggtttaa tcctctgtgt ggttctgctc 3000
aacactggtc tgagtggagc catccgatcc actggggctc aaatacctct aaagaaaatc 3060
cgttcctctt tgcgctcgaa gccgttgtta tcagcgtcgg aagcatggga cttatcattt 3120
cccttctctg cgtgtacttc tggctggagc ggacgatgcc gcggattccg acgctcaaaa 3180
acctggagga ccttgtaaca gaatatcacg gtaatttctc cgcttggagt ggcgtatcaa 3240
aggggcttgc tgagtccctt caaccggatt actctgagcg cctctgcttg gtgtccgaga 3300
tacctcccaa aggaggtgca cttggggagg ggccaggcgc gtccccttgc aatcagcata 3360
gtccgtattg ggcgcccccc tgttataccc tcaaaccgga aacgggaagc ggagctacta 3420
acttcagcct gctgaagcag gctggagacg tggaggagaa ccctggacct atggcactgc 3480
ccgtgaccgc cctgctgctg cctctggccc tgctgctgca cgcagcccgg cctatcctgt 3540
ggcacgagat gtggcacgag ggcctggagg aggccagcag gctgtatttt ggcgagcgca 3600
acgtgaaggg catgttcgag gtgctggagc ctctgcacgc catgatggag agaggcccac 3660
agaccctgaa ggagacatcc tttaaccagg cctatggacg ggacctgatg gaggcacagg 3720
agtggtgcag aaagtacatg aagtctggca atgtgaagga cctgctgcag gcctgggatc 3780
tgtactatca cgtgtttcgg agaatctcca agaaaccttt tgagaacctt agactgatgg 3840
cgcccatctc tctgcaggta gttcacgttg agacccatag atgcaatata agctgggaaa 3900
tctcacaagc cagccattac tttgaacggc atttggaatt cgaggcccga acactttccc 3960
ccggtcatac gtgggaagaa gctcctctct tgacgctgaa gcagaagcag gagtggattt 4020
gtctggagac tttgactcct gatactcagt atgagttcca agttcgggtg aaaccactcc 4080
aaggcgagtt cacgacgtgg tctccgtgga gtcaaccgtt ggcgttccgc acgaagcccg 4140
ctgcccttgg caaagacacg attccgtggc ttgggcatct gctcgttggg ctgagtggtg 4200
cgtttggttt catcatcttg gtctatctct tgatcaattg cagaaataca ggcccttggc 4260
tgaaaaaagt gctcaagtgt aatacccccg acccaagcaa gttcttctcc cagctttctt 4320
cagagcatgg aggcgatgtg cagaaatggc tctcttcacc ttttccctcc tcaagcttct 4380
ccccgggagg gctggcgccc gagatttcac ctcttgaggt acttgaacga gacaaggtta 4440
cccaacttct ccttcaacag gataaggtac ccgaacctgc gagccttagc tccaaccact 4500
ctcttacgag ctgcttcacc aatcagggat acttcttttt ccaccttccc gatgcgctgg 4560
aaatcgaagc ttgtcaagtt tactttacct atgatccata tagcgaggaa gatcccgacg 4620
aaggagtcgc cggtgcgccc acgggttcct caccccaacc tctccagcct ctctcaggag 4680
aagatgatgc ttattgcact tttcccagta gagacgatct cctcctcttt tctccatctc 4740
ttttgggggg accttccccc ccttctacgg cacctggcgg gtctggtgct ggcgaggagc 4800
ggatgccgcc gtccctccag gagcgagtac cacgagattg ggatccccag ccacttggac 4860
cccccacccc cggcgtacct gaccttgtcg attttcaacc tccccctgaa ttggtgctgc 4920
gagaggctgg ggaggaagtt ccggacgctg ggccgaggga gggcgtgtcc tttccatgga 4980
gtaggcctcc aggtcaaggc gagtttaggg ctctcaacgc gcggctgccg ttgaatacag 5040
acgcttatct ctcactgcag gaactgcaag gtcaggaccc aacacatctt gtaggatctg 5100
gtgctactaa tttttctctt ttgaagcaag ctggagatgt tgaagagaac cctggtccag 5160
tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag ctggacggcg 5220
acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc acctacggca 5280
agctgaccct gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg 5340
tgaccaccct gacctacggc gtgcagtgct tcagccgcta ccccgaccac atgaagcagc 5400
acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc atcttcttca 5460
aggacgacgg caactacaag acccgcgccg aggtgaagtt cgagggcgac accctggtga 5520
accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg gggcacaagc 5580
tggagtacaa ctacaacagc cacaacgtct atatcatggc cgacaagcag aagaacggca 5640
tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag ctcgccgacc 5700
actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac aaccactacc 5760
tgagcaccca gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc 5820
tggagttcgt gaccgccgcc gggatcactc tcggcatgga cgagctgtac aagtaaacta 5880
gtgtcgacaa tcaacctctg gattacaaaa tttgtgaaag attgactggt attcttaact 5940
atgttgctcc ttttacgcta tgtggatacg ctgctttaat gcctttgtat catgctattg 6000
cttcccgtat ggctttcatt ttctcctcct tgtataaatc ctggttgctg tctctttatg 6060
aggagttgtg gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt gctgacgcaa 6120
cccccactgg ttggggcatt gccaccacct gtcagctcct ttccgggact ttcgctttcc 6180
ccctccctat tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc tggacagggg 6240
ctcggctgtt gggcactgac aattccgtgg tgttgtcggg gaagctgacg tcctttccat 6300
ggctgctcgc ctgtgttgcc acctggattc tgcgcgggac gtccttctgc tacgtccctt 6360
cggccctcaa tccagcggac cttccttccc gcggcctgct gccggctctg cggcctcttc 6420
cgcgtcttcg ccttcgccct cagacgagtc ggatctccct ttgggccgcc tccccgcctg 6480
gaattcgagc tcggtacctt taagaccaat gacttacaag gcagctgtag atcttagcca 6540
ctttttaaaa gaaaaggggg gactggaagg gctaattcac tcccaacgaa gacaagatct 6600
gctttttgct tgtactgggt ctctctggtt agaccagatc tgagcctggg agctctctgg 6660
ctaactaggg aacccactgc ttaagcctca ataaagcttg ccttgagtgc ttcaagtagt 6720
gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc ctcagaccct tttagtcagt 6780
gtggaaaatc tctagcagta gtagttcatg tcatcttatt attcagtatt tataacttgc 6840
aaagaaatga atatcagaga gtgagaggaa cttgtttatt gcagcttata atggttacaa 6900
ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg 6960
tggtttgtcc aaactcatca atgtatctta tcatgtctgg ctctagctat cccgccccta 7020
actccgccca gttccgccca ttctccgccc catggctgac taattttttt tatttatgca 7080
gaggccgagg ccgcctcggc ctctgagcta ttccagaagt agtgaggagg cttttttgga 7140
ggcctaggct tttgcgtcga gacgtaccca attcgcccta tagtgagtcg tattacgcgc 7200
gctcactggc cgtcgtttta caacgtcgtg actgggaaaa ccctggcgtt acccaactta 7260
atcgccttgc agcacatccc cctttcgcca gctggcgtaa tagcgaagag gcccgcaccg 7320
atcgcccttc ccaacagttg cgcagcctga atggcgaatg gcgcgacgcg ccctgtagcg 7380
gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg 7440
ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc gccggctttc 7500
cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct ttacggcacc 7560
tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg ccctgataga 7620
cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa 7680
ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg attttgccga 7740
tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg aattttaaca 7800
aaatattaac gtttacaatt tcccaggtgg cacttttcgg ggaaatgtgc gcggaacccc 7860
tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg 7920
ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc 7980
ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt 8040
gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct 8100
caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac 8160
ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact 8220
cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa 8280
gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga 8340
taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt 8400
tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga 8460
agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg 8520
caaactatta actggcgaac tacttactct agcttcccgg caacaattaa tagactggat 8580
ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat 8640
tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc 8700
agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga 8760
tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc 8820
agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag 8880
gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc 8940
gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt 9000
tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt 9060
gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat 9120
accaaatact gtccttctag tgtagccgta gttaggccac cacttcaaga actctgtagc 9180
accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa 9240
gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg 9300
ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag 9360
atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag 9420
gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa 9480
cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt 9540
gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg 9600
gttcctggcc ttttgctggc cttttgctca catgttcttt cctgcgttat cccctgattc 9660
tgtggataac cgtattaccg cctttgagtg agctgatacc gctcgccgca gccgaacgac 9720
cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct 9780
ccccgcgcgt tggccgattc attaatgcag ctggcacgac aggtttcccg actggaaagc 9840
gggcagtgag cgcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt 9900
acactttatg cttccggctc gtatgttgtg tggaattgtg agcggataac aatttcacac 9960
aggaaacagc tatgaccatg attacgccaa gcgcgcaatt aaccctcact aaagggaaca 10020
aaagctggag ctgca                                                  10035


<210> 19
<211> 10053
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL2Rg upstream of IL2Rb

<400> 19
agcttaatgt agtcttatgc aatactcttg tagtcttgca acatggtaac gatgagttag 60
caacatgcct tacaaggaga gaaaaagcac cgtgcatgcc gattggtgga agtaaggtgg 120
tacgatcgtg ccttattagg aaggcaacag acgggtctga catggattgg acgaaccact 180
gaattgccgc attgcagaga tattgtattt aagtgcctag ctcgatacaa taaacgggtc 240
tctctggtta gaccagatct gagcctggga gctctctggc taactaggga acccactgct 300
taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga 360
ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtgg 420
cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg agctctctcg acgcaggact 480
cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa 540
attttgacta gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg 600
gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat 660
aaattaaaac atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc 720
ctgttagaaa catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag 780
acaggatcag aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat 840
caaaggatag agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac 900
aaaagtaaga ccaccgcaca gcaagcggcc gctgatcttc agacctggag gaggagatat 960
gagggacaat tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg 1020
agtagcaccc accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat 1080
aggagctttg ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcctcaat 1140
gacgctgacg gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt 1200
gctgagggct attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca 1260
gctccaggca agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat 1320
ttggggttgc tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag 1380
taataaatct ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat 1440
taacaattac acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa 1500
gaatgaacaa gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat 1560
aacaaattgg ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt 1620
aagaatagtt tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt 1680
atcgtttcag acccacctcc caaccccgag gggacccgac aggcccgaag gaatagaaga 1740
agaaggtgga gagagagaca gagacagatc cattcgatta gtgaacggat ctcgacggta 1800
tcggttaact tttaaaagaa aaggggggat tggggggtac agtgcagggg aaagaatagt 1860
agacataata gcaacagaca tacaaactaa agaattacaa aaacaaatta caaaaattca 1920
aaattttatc gatcacgaga ctagcctcga gaagcttgat atcgaattcc cacggggttg 1980
gacgcgtagg aacagagaaa caggagaata tgggccaaac aggatatctg tggtaagcag 2040
ttcctgcccc ggctcagggc caagaacagt tggaacagca gaatatgggc caaacaggat 2100
atctgtggta agcagttcct gccccggctc agggccaaga acagatggtc cccagatgcg 2160
gtcccgccct cagcagtttc tagagaacca tcagatgttt ccagggtgcc ccaaggacct 2220
gaaatgaccc tgtgccttat ttgaactaac caatcagttc gcttctcgct tctgttcgcg 2280
cgcttctgct ccccgagctc tatataagca gagctcgttt agtgaaccgt cagatcgcta 2340
gcaccggtgc cgccaccatg cctctgggcc tgctgtggct gggcctggcc ctgctgggcg 2400
ccctgcacgc ccaggccggc gtgcaggtgg agacaatctc cccaggcgac ggacgcacat 2460
tccctaagcg gggccagacc tgcgtggtgc actatacagg catgctggag gatggcaaga 2520
agtttgacag ctcccgggat agaaacaagc cattcaagtt tatgctgggc aagcaggaag 2580
tgatcagagg ctgggaggag ggcgtggccc agatgtctgt gggccagagg gccaagctga 2640
ccatcagccc agactacgcc tatggagcaa caggccaccc aggaatcatc ccacctcacg 2700
ccaccctggt gttcgatgtg gagctgctga agctgggcga gggcggtagt cagaaccttg 2760
tgataccatg ggccccagaa aatctcacac ttcataaact ttccgaatca caactcgaac 2820
tcaactggaa taaccggttc ctgaatcact gtcttgaaca cctggtacaa tatcggaccg 2880
actgggatca ctcatggaca gaacaatctg tggactatag gcacaaattc tcactcccaa 2940
gcgtagacgg ccaaaaaaga tacacttttc gcgtacgatc ccgctttaat cctctctgcg 3000
gctctgctca gcactggagt gaatggtccc atcccattca ttggggatcc aacacatcaa 3060
aagagaaccc ctttctgttc gcattggagg ccgtagtcat atctgttgga tccatgggac 3120
ttattatctc cctgttgtgt gtgtacttct ggctggaacg gactatgccc aggatcccca 3180
cgctcaagaa tctggaagat ctcgtcacag aataccatgg taatttcagc gcctggagcg 3240
gagtctctaa gggtctggcc gaatccctcc aacccgatta ttctgaacgg ttgtgcctcg 3300
tatccgaaat accaccaaaa ggcggggctc tgggtgaggg cccaggggcg agtccgtgca 3360
atcaacacag cccgtattgg gcccctcctt gttatacgtt gaagcccgaa actggaagcg 3420
gagctactaa cttcagcctg ctgaagcagg ctggagacgt ggaggagaac cctggaccta 3480
tggcactgcc cgtgaccgcc ctgctgctgc ctctggccct gctgctgcac gcagcccggc 3540
ctatcctgtg gcacgagatg tggcacgagg gcctggagga ggccagcagg ctgtattttg 3600
gcgagcgcaa cgtgaagggc atgttcgagg tgctggagcc tctgcacgcc atgatggaga 3660
gaggcccaca gaccctgaag gagacatcct ttaaccaggc ctatggacgg gacctgatgg 3720
aggcacagga gtggtgcaga aagtacatga agtctggcaa tgtgaaggac ctgctgcagg 3780
cctgggatct gtactatcac gtgtttcgga gaatctccaa gggaggttca aaaccttttg 3840
agaaccttag actgatggcg cccatctctc tgcaggtagt tcacgttgag acccatagat 3900
gcaatataag ctgggaaatc tcacaagcca gccattactt tgaacggcat ttggaattcg 3960
aggcccgaac actttccccc ggtcatacgt gggaagaagc tcctctcttg acgctgaagc 4020
agaagcagga gtggatttgt ctggagactt tgactcctga tactcagtat gagttccaag 4080
ttcgggtgaa accactccaa ggcgagttca cgacgtggtc tccgtggagt caaccgttgg 4140
cgttccgcac gaagcccgct gcccttggca aagacacgat tccgtggctt gggcatctgc 4200
tcgttgggct gagtggtgcg tttggtttca tcatcttggt ctatctcttg atcaattgca 4260
gaaatacagg cccttggctg aaaaaagtgc tcaagtgtaa tacccccgac ccaagcaagt 4320
tcttctccca gctttcttca gagcatggag gcgatgtgca gaaatggctc tcttcacctt 4380
ttccctcctc aagcttctcc ccgggagggc tggcgcccga gatttcacct cttgaggtac 4440
ttgaacgaga caaggttacc caacttctcc ttcaacagga taaggtaccc gaacctgcga 4500
gccttagctc caaccactct cttacgagct gcttcaccaa tcagggatac ttctttttcc 4560
accttcccga tgcgctggaa atcgaagctt gtcaagttta ctttacctat gatccatata 4620
gcgaggaaga tcccgacgaa ggagtcgccg gtgcgcccac gggttcctca ccccaacctc 4680
tccagcctct ctcaggagaa gatgatgctt attgcacttt tcccagtaga gacgatctcc 4740
tcctcttttc tccatctctt ttggggggac cttccccccc ttctacggca cctggcgggt 4800
ctggtgctgg cgaggagcgg atgccgccgt ccctccagga gcgagtacca cgagattggg 4860
atccccagcc acttggaccc cccacccccg gcgtacctga ccttgtcgat tttcaacctc 4920
cccctgaatt ggtgctgcga gaggctgggg aggaagttcc ggacgctggg ccgagggagg 4980
gcgtgtcctt tccatggagt aggcctccag gtcaaggcga gtttagggct ctcaacgcgc 5040
ggctgccgtt gaatacagac gcttatctct cactgcagga actgcaaggt caggacccaa 5100
cacatcttgt aggatctggt gctactaatt tttctctttt gaagcaagct ggagatgttg 5160
aagagaaccc tggtccagtg agcaagggcg aggagctgtt caccggggtg gtgcccatcc 5220
tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc gagggcgagg 5280
gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc aagctgcccg 5340
tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc agccgctacc 5400
ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc tacgtccagg 5460
agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag gtgaagttcg 5520
agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag gaggacggca 5580
acatcctggg gcacaagctg gagtacaact acaacagcca caacgtctat atcatggccg 5640
acaagcagaa gaacggcatc aaggtgaact tcaagatccg ccacaacatc gaggacggca 5700
gcgtgcagct cgccgaccac taccagcaga acacccccat cggcgacggc cccgtgctgc 5760
tgcccgacaa ccactacctg agcacccagt ccgccctgag caaagacccc aacgagaagc 5820
gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg gatcactctc ggcatggacg 5880
agctgtacaa gtaaactagt gtcgacaatc aacctctgga ttacaaaatt tgtgaaagat 5940
tgactggtat tcttaactat gttgctcctt ttacgctatg tggatacgct gctttaatgc 6000
ctttgtatca tgctattgct tcccgtatgg ctttcatttt ctcctccttg tataaatcct 6060
ggttgctgtc tctttatgag gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca 6120
ctgtgtttgc tgacgcaacc cccactggtt ggggcattgc caccacctgt cagctccttt 6180
ccgggacttt cgctttcccc ctccctattg ccacggcgga actcatcgcc gcctgccttg 6240
cccgctgctg gacaggggct cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga 6300
agctgacgtc ctttccatgg ctgctcgcct gtgttgccac ctggattctg cgcgggacgt 6360
ccttctgcta cgtcccttcg gccctcaatc cagcggacct tccttcccgc ggcctgctgc 6420
cggctctgcg gcctcttccg cgtcttcgcc ttcgccctca gacgagtcgg atctcccttt 6480
gggccgcctc cccgcctgga attcgagctc ggtaccttta agaccaatga cttacaaggc 6540
agctgtagat cttagccact ttttaaaaga aaagggggga ctggaagggc taattcactc 6600
ccaacgaaga caagatctgc tttttgcttg tactgggtct ctctggttag accagatctg 6660
agcctgggag ctctctggct aactagggaa cccactgctt aagcctcaat aaagcttgcc 6720
ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac tctggtaact agagatccct 6780
cagacccttt tagtcagtgt ggaaaatctc tagcagtagt agttcatgtc atcttattat 6840
tcagtattta taacttgcaa agaaatgaat atcagagagt gagaggaact tgtttattgc 6900
agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt 6960
ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggct 7020
ctagctatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca tggctgacta 7080
atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt ccagaagtag 7140
tgaggaggct tttttggagg cctaggcttt tgcgtcgaga cgtacccaat tcgccctata 7200
gtgagtcgta ttacgcgcgc tcactggccg tcgttttaca acgtcgtgac tgggaaaacc 7260
ctggcgttac ccaacttaat cgccttgcag cacatccccc tttcgccagc tggcgtaata 7320
gcgaagaggc ccgcaccgat cgcccttccc aacagttgcg cagcctgaat ggcgaatggc 7380
gcgacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga 7440
ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg 7500
ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat 7560
ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg 7620
ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata 7680
gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt 7740
tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat 7800
ttaacgcgaa ttttaacaaa atattaacgt ttacaatttc ccaggtggca cttttcgggg 7860
aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct 7920
catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat 7980
tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc 8040
tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg 8100
ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg 8160
ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtattga 8220
cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta 8280
ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc 8340
tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc 8400
gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg 8460
ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc 8520
aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca 8580
acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct 8640
tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat 8700
cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg 8760
gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat 8820
taagcattgg taactgtcag accaagttta ctcatatata ctttagattg atttaaaact 8880
tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat 8940
cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc 9000
ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct 9060
accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg 9120
cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca 9180
cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc 9240
tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga 9300
taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac 9360
gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga 9420
agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag 9480
ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg 9540
acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag 9600
caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc 9660
tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc 9720
tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc 9780
aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag 9840
gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt agctcactca 9900
ttaggcaccc caggctttac actttatgct tccggctcgt atgttgtgtg gaattgtgag 9960
cggataacaa tttcacacag gaaacagcta tgaccatgat tacgccaagc gcgcaattaa 10020
ccctcactaa agggaacaaa agctggagct gca                              10053


<210> 20
<211> 9405
<212> DNA
<213> Artificial Sequence

<220> 
<223> IL2Rg upstream of IL2Rb

<400> 20
agcttaatgt agtcttatgc aatactcttg tagtcttgca acatggtaac gatgagttag 60
caacatgcct tacaaggaga gaaaaagcac cgtgcatgcc gattggtgga agtaaggtgg 120
tacgatcgtg ccttattagg aaggcaacag acgggtctga catggattgg acgaaccact 180
gaattgccgc attgcagaga tattgtattt aagtgcctag ctcgatacaa taaacgggtc 240
tctctggtta gaccagatct gagcctggga gctctctggc taactaggga acccactgct 300
taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga 360
ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtgg 420
cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg agctctctcg acgcaggact 480
cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa 540
attttgacta gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg 600
gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat 660
aaattaaaac atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc 720
ctgttagaaa catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag 780
acaggatcag aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat 840
caaaggatag agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac 900
aaaagtaaga ccaccgcaca gcaagcggcc gctgatcttc agacctggag gaggagatat 960
gagggacaat tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg 1020
agtagcaccc accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat 1080
aggagctttg ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcctcaat 1140
gacgctgacg gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt 1200
gctgagggct attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca 1260
gctccaggca agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat 1320
ttggggttgc tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag 1380
taataaatct ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat 1440
taacaattac acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa 1500
gaatgaacaa gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat 1560
aacaaattgg ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt 1620
aagaatagtt tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt 1680
atcgtttcag acccacctcc caaccccgag gggacccgac aggcccgaag gaatagaaga 1740
agaaggtgga gagagagaca gagacagatc cattcgatta gtgaacggat ctcgacggta 1800
tcggttaact tttaaaagaa aaggggggat tggggggtac agtgcagggg aaagaatagt 1860
agacataata gcaacagaca tacaaactaa agaattacaa aaacaaatta caaaaattca 1920
aaattttatc gatcacgaga ctagcctcga gaagcttgat atcgaattcc cacggggttg 1980
gacgcgtagg aacagagaaa caggagaata tgggccaaac aggatatctg tggtaagcag 2040
ttcctgcccc ggctcagggc caagaacagt tggaacagca gaatatgggc caaacaggat 2100
atctgtggta agcagttcct gccccggctc agggccaaga acagatggtc cccagatgcg 2160
gtcccgccct cagcagtttc tagagaacca tcagatgttt ccagggtgcc ccaaggacct 2220
gaaatgaccc tgtgccttat ttgaactaac caatcagttc gcttctcgct tctgttcgcg 2280
cgcttctgct ccccgagctc tatataagca gagctcgttt agtgaaccgt cagatcgcta 2340
gcaccggtgc cgccaccatg cctctgggcc tgctgtggct gggcctggcc ctgctgggcg 2400
ccctgcacgc ccaggccggc gtgcaggtgg agacaatctc cccaggcgac ggacgcacat 2460
tccctaagcg gggccagacc tgcgtggtgc actatacagg catgctggag gatggcaaga 2520
agtttgacag ctcccgggat agaaacaagc cattcaagtt tatgctgggc aagcaggaag 2580
tgatcagagg ctgggaggag ggcgtggccc agatgtctgt gggccagagg gccaagctga 2640
ccatcagccc agactacgcc tatggagcaa caggccaccc aggaatcatc ccacctcacg 2700
ccaccctggt gttcgatgtg gagctgctga agctgggcga gggatccaac acatcaaaag 2760
agaacccctt tctgttcgca ttggaggccg tagtcatatc tgttggatcc atgggactta 2820
ttatctccct gttgtgtgtg tacttctggc tggaacggac tatgcccagg atccccacgc 2880
tcaagaatct ggaagatctc gtcacagaat accatggtaa tttcagcgcc tggagcggag 2940
tctctaaggg tctggccgaa tccctccaac ccgattattc tgaacggttg tgcctcgtat 3000
ccgaaatacc accaaaaggc ggggctctgg gtgagggccc aggggcgagt ccgtgcaatc 3060
aacacagccc gtattgggcc cctccttgtt atacgttgaa gcccgaaact ggaagcggag 3120
ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct ggacctatgg 3180
cactgcccgt gaccgccctg ctgctgcctc tggccctgct gctgcacgca gcccggccta 3240
tcctgtggca cgagatgtgg cacgagggcc tggaggaggc cagcaggctg tattttggcg 3300
agcgcaacgt gaagggcatg ttcgaggtgc tggagcctct gcacgccatg atggagagag 3360
gcccacagac cctgaaggag acatccttta accaggccta tggacgggac ctgatggagg 3420
cacaggagtg gtgcagaaag tacatgaagt ctggcaatgt gaaggacctg ctgcaggcct 3480
gggatctgta ctatcacgtg tttcggagaa tctccaaggg caaagacacg attccgtggc 3540
ttgggcatct gctcgttggg ctgagtggtg cgtttggttt catcatcttg gtctatctct 3600
tgatcaattg cagaaataca ggcccttggc tgaaaaaagt gctcaagtgt aatacccccg 3660
acccaagcaa gttcttctcc cagctttctt cagagcatgg aggcgatgtg cagaaatggc 3720
tctcttcacc ttttccctcc tcaagcttct ccccgggagg gctggcgccc gagatttcac 3780
ctcttgaggt acttgaacga gacaaggtta cccaacttct ccttcaacag gataaggtac 3840
ccgaacctgc gagccttagc tccaaccact ctcttacgag ctgcttcacc aatcagggat 3900
acttcttttt ccaccttccc gatgcgctgg aaatcgaagc ttgtcaagtt tactttacct 3960
atgatccata tagcgaggaa gatcccgacg aaggagtcgc cggtgcgccc acgggttcct 4020
caccccaacc tctccagcct ctctcaggag aagatgatgc ttattgcact tttcccagta 4080
gagacgatct cctcctcttt tctccatctc ttttgggggg accttccccc ccttctacgg 4140
cacctggcgg gtctggtgct ggcgaggagc ggatgccgcc gtccctccag gagcgagtac 4200
cacgagattg ggatccccag ccacttggac cccccacccc cggcgtacct gaccttgtcg 4260
attttcaacc tccccctgaa ttggtgctgc gagaggctgg ggaggaagtt ccggacgctg 4320
ggccgaggga gggcgtgtcc tttccatgga gtaggcctcc aggtcaaggc gagtttaggg 4380
ctctcaacgc gcggctgccg ttgaatacag acgcttatct ctcactgcag gaactgcaag 4440
gtcaggaccc aacacatctt gtaggatctg gtgctactaa tttttctctt ttgaagcaag 4500
ctggagatgt tgaagagaac cctggtccag tgagcaaggg cgaggagctg ttcaccgggg 4560
tggtgcccat cctggtcgag ctggacggcg acgtaaacgg ccacaagttc agcgtgtccg 4620
gcgagggcga gggcgatgcc acctacggca agctgaccct gaagttcatc tgcaccaccg 4680
gcaagctgcc cgtgccctgg cccaccctcg tgaccaccct gacctacggc gtgcagtgct 4740
tcagccgcta ccccgaccac atgaagcagc acgacttctt caagtccgcc atgcccgaag 4800
gctacgtcca ggagcgcacc atcttcttca aggacgacgg caactacaag acccgcgccg 4860
aggtgaagtt cgagggcgac accctggtga accgcatcga gctgaagggc atcgacttca 4920
aggaggacgg caacatcctg gggcacaagc tggagtacaa ctacaacagc cacaacgtct 4980
atatcatggc cgacaagcag aagaacggca tcaaggtgaa cttcaagatc cgccacaaca 5040
tcgaggacgg cagcgtgcag ctcgccgacc actaccagca gaacaccccc atcggcgacg 5100
gccccgtgct gctgcccgac aaccactacc tgagcaccca gtccgccctg agcaaagacc 5160
ccaacgagaa gcgcgatcac atggtcctgc tggagttcgt gaccgccgcc gggatcactc 5220
tcggcatgga cgagctgtac aagtaaacta gtgtcgacaa tcaacctctg gattacaaaa 5280
tttgtgaaag attgactggt attcttaact atgttgctcc ttttacgcta tgtggatacg 5340
ctgctttaat gcctttgtat catgctattg cttcccgtat ggctttcatt ttctcctcct 5400
tgtataaatc ctggttgctg tctctttatg aggagttgtg gcccgttgtc aggcaacgtg 5460
gcgtggtgtg cactgtgttt gctgacgcaa cccccactgg ttggggcatt gccaccacct 5520
gtcagctcct ttccgggact ttcgctttcc ccctccctat tgccacggcg gaactcatcg 5580
ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt gggcactgac aattccgtgg 5640
tgttgtcggg gaagctgacg tcctttccat ggctgctcgc ctgtgttgcc acctggattc 5700
tgcgcgggac gtccttctgc tacgtccctt cggccctcaa tccagcggac cttccttccc 5760
gcggcctgct gccggctctg cggcctcttc cgcgtcttcg ccttcgccct cagacgagtc 5820
ggatctccct ttgggccgcc tccccgcctg gaattcgagc tcggtacctt taagaccaat 5880
gacttacaag gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg 5940
gctaattcac tcccaacgaa gacaagatct gctttttgct tgtactgggt ctctctggtt 6000
agaccagatc tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca 6060
ataaagcttg ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa 6120
ctagagatcc ctcagaccct tttagtcagt gtggaaaatc tctagcagta gtagttcatg 6180
tcatcttatt attcagtatt tataacttgc aaagaaatga atatcagaga gtgagaggaa 6240
cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa 6300
taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta 6360
tcatgtctgg ctctagctat cccgccccta actccgccca gttccgccca ttctccgccc 6420
catggctgac taattttttt tatttatgca gaggccgagg ccgcctcggc ctctgagcta 6480
ttccagaagt agtgaggagg cttttttgga ggcctaggct tttgcgtcga gacgtaccca 6540
attcgcccta tagtgagtcg tattacgcgc gctcactggc cgtcgtttta caacgtcgtg 6600
actgggaaaa ccctggcgtt acccaactta atcgccttgc agcacatccc cctttcgcca 6660
gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc ccaacagttg cgcagcctga 6720
atggcgaatg gcgcgacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta 6780
cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc 6840
cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt 6900
tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat tagggtgatg 6960
gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca 7020
cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcggtct 7080
attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga 7140
tttaacaaaa atttaacgcg aattttaaca aaatattaac gtttacaatt tcccaggtgg 7200
cacttttcgg ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa 7260
tatgtatccg ctcatgagac aataaccctg ataaatgctt caataatatt gaaaaaggaa 7320
gagtatgagt attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct 7380
tcctgttttt gctcacccag aaacgctggt gaaagtaaaa gatgctgaag atcagttggg 7440
tgcacgagtg ggttacatcg aactggatct caacagcggt aagatccttg agagttttcg 7500
ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt 7560
atcccgtatt gacgccgggc aagagcaact cggtcgccgc atacactatt ctcagaatga 7620
cttggttgag tactcaccag tcacagaaaa gcatcttacg gatggcatga cagtaagaga 7680
attatgcagt gctgccataa ccatgagtga taacactgcg gccaacttac ttctgacaac 7740
gatcggagga ccgaaggagc taaccgcttt tttgcacaac atgggggatc atgtaactcg 7800
ccttgatcgt tgggaaccgg agctgaatga agccatacca aacgacgagc gtgacaccac 7860
gatgcctgta gcaatggcaa caacgttgcg caaactatta actggcgaac tacttactct 7920
agcttcccgg caacaattaa tagactggat ggaggcggat aaagttgcag gaccacttct 7980
gcgctcggcc cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg 8040
gtctcgcggt atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat 8100
ctacacgacg gggagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg 8160
tgcctcactg attaagcatt ggtaactgtc agaccaagtt tactcatata tactttagat 8220
tgatttaaaa cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct 8280
catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa 8340
gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa 8400
aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc 8460
gaaggtaact ggcttcagca gagcgcagat accaaatact gtccttctag tgtagccgta 8520
gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct 8580
gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg 8640
atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag 8700
cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc 8760
cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg 8820
agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt 8880
tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg 8940
gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca 9000
catgttcttt cctgcgttat cccctgattc tgtggataac cgtattaccg cctttgagtg 9060
agctgatacc gctcgccgca gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc 9120
ggaagagcgc ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatgcag 9180
ctggcacgac aggtttcccg actggaaagc gggcagtgag cgcaacgcaa ttaatgtgag 9240
ttagctcact cattaggcac cccaggcttt acactttatg cttccggctc gtatgttgtg 9300
tggaattgtg agcggataac aatttcacac aggaaacagc tatgaccatg attacgccaa 9360
gcgcgcaatt aaccctcact aaagggaaca aaagctggag ctgca                 9405
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