                         SEQUENCE LISTING

<110>  Danisco US Inc.
 
<120>  BI-FUNCTIONAL PHOSPHOKETOLASE-PHOSPHOTRANSACETYLASE FUSION 
       POLYPEPTIDES

<130>  NB41170-WO-PCT

<140>  PCT/US17/65680
<141>  2017-12-12

<150>  62/435212
<151>  2016-12-16

<150>  62556788
<151>  2017-09-11

<150>  62/520604
<151>  2017-06-16

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  825
<212>  PRT
<213>  Gardnerella vaginalis

<400>  1

Met Thr Ser Pro Val Ile Gly Thr Pro Trp Lys Lys Leu Asn Ala Pro 
1               5                   10                  15      


Val Ser Glu Ala Ala Ile Glu Gly Val Asp Lys Tyr Trp Arg Val Ala 
            20                  25                  30          


Asn Tyr Leu Ser Ile Gly Gln Ile Tyr Leu Arg Ser Asn Pro Leu Met 
        35                  40                  45              


Lys Glu Pro Phe Thr Arg Glu Asp Val Lys His Arg Leu Val Gly His 
    50                  55                  60                  


Trp Gly Thr Thr Pro Gly Leu Asn Phe Leu Ile Gly His Ile Asn Arg 
65                  70                  75                  80  


Phe Ile Ala Glu His Gln Gln Asn Thr Val Ile Ile Met Gly Pro Gly 
                85                  90                  95      


His Gly Gly Pro Ala Gly Thr Ala Gln Ser Tyr Leu Asp Gly Thr Tyr 
            100                 105                 110         


Thr Glu Tyr Tyr Pro Lys Ile Thr Lys Asp Glu Ala Gly Leu Gln Lys 
        115                 120                 125             


Phe Phe Arg Gln Phe Ser Tyr Pro Gly Gly Ile Pro Ser His Phe Ala 
    130                 135                 140                 


Pro Glu Thr Pro Gly Ser Ile His Glu Gly Gly Glu Leu Gly Tyr Ala 
145                 150                 155                 160 


Leu Ser His Ala Tyr Gly Ala Val Met Asn Asn Pro Ser Leu Phe Val 
                165                 170                 175     


Pro Ala Ile Val Gly Asp Gly Glu Ala Glu Thr Gly Pro Leu Ala Thr 
            180                 185                 190         


Gly Trp Gln Ser Asn Lys Leu Val Asn Pro Arg Thr Asp Gly Ile Val 
        195                 200                 205             


Leu Pro Ile Leu His Leu Asn Gly Tyr Lys Ile Ala Asn Pro Thr Ile 
    210                 215                 220                 


Leu Ser Arg Ile Ser Asp Glu Glu Leu His Glu Phe Phe His Gly Met 
225                 230                 235                 240 


Gly Tyr Glu Pro Tyr Glu Phe Val Ala Gly Phe Asp Asp Glu Asp His 
                245                 250                 255     


Met Ser Ile His Arg Arg Phe Ala Asp Met Phe Glu Thr Ile Phe Asp 
            260                 265                 270         


Glu Ile Cys Asp Ile Lys Ala Glu Ala Gln Thr Asn Asp Val Thr Arg 
        275                 280                 285             


Pro Phe Tyr Pro Met Ile Ile Phe Arg Thr Pro Lys Gly Trp Thr Cys 
    290                 295                 300                 


Pro Lys Phe Ile Asp Gly Lys Lys Thr Glu Gly Ser Trp Arg Ala His 
305                 310                 315                 320 


Gln Val Pro Leu Ala Ser Ala Arg Asp Thr Glu Ala His Phe Glu Val 
                325                 330                 335     


Leu Lys Asn Trp Leu Lys Ser Tyr Lys Pro Glu Glu Leu Phe Asn Glu 
            340                 345                 350         


Asp Gly Ser Ile Lys Glu Asp Val Leu Ser Phe Met Pro Gln Gly Glu 
        355                 360                 365             


Leu Arg Ile Gly Gln Asn Pro Asn Ala Asn Gly Gly Arg Ile Arg Glu 
    370                 375                 380                 


Asp Leu Lys Leu Pro Asn Leu Asp Asp Tyr Glu Val Lys Glu Val Lys 
385                 390                 395                 400 


Glu Phe Gly His Gly Trp Gly Gln Leu Glu Ala Thr Arg Arg Leu Gly 
                405                 410                 415     


Val Tyr Thr Arg Asp Val Ile Lys Asn Asn Pro Asp Ser Phe Arg Ile 
            420                 425                 430         


Phe Gly Pro Asp Glu Thr Ala Ser Asn Arg Leu Gln Ala Ala Tyr Glu 
        435                 440                 445             


Val Thr Asn Lys Gln Trp Asp Ala Gly Tyr Leu Ser Glu Leu Val Asp 
    450                 455                 460                 


Glu His Met Ala Val Thr Gly Gln Val Thr Glu Gln Leu Ser Glu His 
465                 470                 475                 480 


Gln Met Glu Gly Phe Leu Glu Ala Tyr Leu Leu Thr Gly Arg His Gly 
                485                 490                 495     


Ile Trp Ser Ser Tyr Glu Ser Phe Val His Val Ile Asp Ser Met Leu 
            500                 505                 510         


Asn Gln His Ala Lys Trp Leu Glu Ala Thr Val Arg Glu Ile Pro Trp 
        515                 520                 525             


Arg Lys Pro Ile Ser Ser Met Asn Leu Leu Val Ser Ser His Val Trp 
    530                 535                 540                 


Arg Gln Asp His Asn Gly Phe Ser His Gln Asp Pro Gly Val Thr Ser 
545                 550                 555                 560 


Val Leu Leu Asn Lys Thr Phe Asn Asn Asp His Val Ile Gly Ile Tyr 
                565                 570                 575     


Phe Pro Val Asp Ser Asn Met Leu Leu Ala Val Gly Glu Lys Val Tyr 
            580                 585                 590         


Lys Ser Thr Asn Met Ile Asn Ala Ile Phe Ala Gly Lys Gln Pro Ala 
        595                 600                 605             


Ala Thr Trp Leu Thr Leu Asp Glu Ala Arg Glu Glu Leu Glu Lys Gly 
    610                 615                 620                 


Ala Ala Glu Trp Lys Trp Ala Ser Asn Ala Lys Asn Asn Asp Glu Val 
625                 630                 635                 640 


Gln Val Val Leu Ala Gly Ile Gly Asp Val Pro Gln Gln Glu Leu Met 
                645                 650                 655     


Ala Ala Ala Asp Lys Leu Asn Lys Leu Gly Val Lys Phe Lys Val Val 
            660                 665                 670         


Asn Ile Val Asp Leu Leu Lys Leu Gln Ser Ala Lys Glu Asn Asn Glu 
        675                 680                 685             


Ala Leu Thr Asp Glu Glu Phe Thr Glu Leu Phe Thr Ala Asp Lys Pro 
    690                 695                 700                 


Val Leu Leu Ala Tyr His Ser Tyr Ala His Asp Val Arg Gly Leu Ile 
705                 710                 715                 720 


Phe Asp Arg Pro Asn His Asp Asn Phe Asn Val His Gly Tyr Lys Glu 
                725                 730                 735     


Gln Gly Ser Thr Thr Thr Pro Tyr Asp Met Val Arg Val Asn Asp Met 
            740                 745                 750         


Asp Arg Tyr Glu Leu Thr Ala Glu Ala Leu Arg Met Val Asp Ala Asp 
        755                 760                 765             


Lys Tyr Ala Asp Glu Ile Lys Lys Leu Glu Asp Phe Arg Leu Glu Ala 
    770                 775                 780                 


Phe Gln Phe Ala Val Asp Lys Gly Tyr Asp His Pro Asp Tyr Thr Asp 
785                 790                 795                 800 


Trp Val Trp Pro Gly Val Lys Thr Asp Lys Pro Gly Ala Val Thr Ala 
                805                 810                 815     


Thr Ala Ala Thr Ala Gly Asp Asn Glu 
            820                 825 


<210>  2
<211>  325
<212>  PRT
<213>  Lactobacillus plantarum

<400>  2

Met Asp Leu Phe Glu Ser Leu Ala Gln Lys Ile Thr Gly Lys Asp Gln 
1               5                   10                  15      


Thr Ile Val Phe Pro Glu Gly Thr Glu Pro Arg Ile Val Gly Ala Ala 
            20                  25                  30          


Ala Arg Leu Ala Ala Asp Gly Leu Val Lys Pro Ile Val Leu Gly Ala 
        35                  40                  45              


Thr Asp Lys Val Gln Ala Val Ala Asn Asp Leu Asn Ala Asp Leu Thr 
    50                  55                  60                  


Gly Val Gln Val Leu Asp Pro Ala Thr Tyr Pro Ala Glu Asp Lys Gln 
65                  70                  75                  80  


Ala Met Leu Asp Ala Leu Val Glu Arg Arg Lys Gly Lys Asn Thr Pro 
                85                  90                  95      


Glu Gln Ala Ala Lys Met Leu Glu Asp Glu Asn Tyr Phe Gly Thr Met 
            100                 105                 110         


Leu Val Tyr Met Gly Lys Ala Asp Gly Met Val Ser Gly Ala Ile His 
        115                 120                 125             


Pro Thr Gly Asp Thr Val Arg Pro Ala Leu Gln Ile Ile Lys Thr Lys 
    130                 135                 140                 


Pro Gly Ser His Arg Ile Ser Gly Ala Phe Ile Met Gln Lys Gly Glu 
145                 150                 155                 160 


Glu Arg Tyr Val Phe Ala Asp Cys Ala Ile Asn Ile Asp Pro Asp Ala 
                165                 170                 175     


Asp Thr Leu Ala Glu Ile Ala Thr Gln Ser Ala Ala Thr Ala Lys Val 
            180                 185                 190         


Phe Asp Ile Asp Pro Lys Val Ala Met Leu Ser Phe Ser Thr Lys Gly 
        195                 200                 205             


Ser Ala Lys Gly Glu Met Val Thr Lys Val Gln Glu Ala Thr Ala Lys 
    210                 215                 220                 


Ala Gln Ala Ala Glu Pro Glu Leu Ala Ile Asp Gly Glu Leu Gln Phe 
225                 230                 235                 240 


Asp Ala Ala Phe Val Glu Lys Val Gly Leu Gln Lys Ala Pro Gly Ser 
                245                 250                 255     


Lys Val Ala Gly His Ala Asn Val Phe Val Phe Pro Glu Leu Gln Ser 
            260                 265                 270         


Gly Asn Ile Gly Tyr Lys Ile Ala Gln Arg Phe Gly His Phe Glu Ala 
        275                 280                 285             


Val Gly Pro Val Leu Gln Gly Leu Asn Lys Pro Val Ser Asp Leu Ser 
    290                 295                 300                 


Arg Gly Cys Ser Glu Glu Asp Val Tyr Lys Val Ala Ile Ile Thr Ala 
305                 310                 315                 320 


Ala Gln Gly Leu Ala 
                325 


<210>  3
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3

Gly Ala Gly Pro Ala Arg Pro Ala Gly Leu Pro Pro Ala Thr Tyr Tyr 
1               5                   10                  15      


Asp Ser Leu Ala Val Thr Ser 
            20              


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4

Ala Gly Gly Gly Gly Thr Ser 
1               5           


<210>  5
<211>  1173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5

Met Thr Ser Pro Val Ile Gly Thr Pro Trp Lys Lys Leu Asn Ala Pro 
1               5                   10                  15      


Val Ser Glu Ala Ala Ile Glu Gly Val Asp Lys Tyr Trp Arg Val Ala 
            20                  25                  30          


Asn Tyr Leu Ser Ile Gly Gln Ile Tyr Leu Arg Ser Asn Pro Leu Met 
        35                  40                  45              


Lys Glu Pro Phe Thr Arg Glu Asp Val Lys His Arg Leu Val Gly His 
    50                  55                  60                  


Trp Gly Thr Thr Pro Gly Leu Asn Phe Leu Ile Gly His Ile Asn Arg 
65                  70                  75                  80  


Phe Ile Ala Glu His Gln Gln Asn Thr Val Ile Ile Met Gly Pro Gly 
                85                  90                  95      


His Gly Gly Pro Ala Gly Thr Ala Gln Ser Tyr Leu Asp Gly Thr Tyr 
            100                 105                 110         


Thr Glu Tyr Tyr Pro Lys Ile Thr Lys Asp Glu Ala Gly Leu Gln Lys 
        115                 120                 125             


Phe Phe Arg Gln Phe Ser Tyr Pro Gly Gly Ile Pro Ser His Phe Ala 
    130                 135                 140                 


Pro Glu Thr Pro Gly Ser Ile His Glu Gly Gly Glu Leu Gly Tyr Ala 
145                 150                 155                 160 


Leu Ser His Ala Tyr Gly Ala Val Met Asn Asn Pro Ser Leu Phe Val 
                165                 170                 175     


Pro Ala Ile Val Gly Asp Gly Glu Ala Glu Thr Gly Pro Leu Ala Thr 
            180                 185                 190         


Gly Trp Gln Ser Asn Lys Leu Val Asn Pro Arg Thr Asp Gly Ile Val 
        195                 200                 205             


Leu Pro Ile Leu His Leu Asn Gly Tyr Lys Ile Ala Asn Pro Thr Ile 
    210                 215                 220                 


Leu Ser Arg Ile Ser Asp Glu Glu Leu His Glu Phe Phe His Gly Met 
225                 230                 235                 240 


Gly Tyr Glu Pro Tyr Glu Phe Val Ala Gly Phe Asp Asp Glu Asp His 
                245                 250                 255     


Met Ser Ile His Arg Arg Phe Ala Asp Met Phe Glu Thr Ile Phe Asp 
            260                 265                 270         


Glu Ile Cys Asp Ile Lys Ala Glu Ala Gln Thr Asn Asp Val Thr Arg 
        275                 280                 285             


Pro Phe Tyr Pro Met Ile Ile Phe Arg Thr Pro Lys Gly Trp Thr Cys 
    290                 295                 300                 


Pro Lys Phe Ile Asp Gly Lys Lys Thr Glu Gly Ser Trp Arg Ala His 
305                 310                 315                 320 


Gln Val Pro Leu Ala Ser Ala Arg Asp Thr Glu Ala His Phe Glu Val 
                325                 330                 335     


Leu Lys Asn Trp Leu Lys Ser Tyr Lys Pro Glu Glu Leu Phe Asn Glu 
            340                 345                 350         


Asp Gly Ser Ile Lys Glu Asp Val Leu Ser Phe Met Pro Gln Gly Glu 
        355                 360                 365             


Leu Arg Ile Gly Gln Asn Pro Asn Ala Asn Gly Gly Arg Ile Arg Glu 
    370                 375                 380                 


Asp Leu Lys Leu Pro Asn Leu Asp Asp Tyr Glu Val Lys Glu Val Lys 
385                 390                 395                 400 


Glu Phe Gly His Gly Trp Gly Gln Leu Glu Ala Thr Arg Arg Leu Gly 
                405                 410                 415     


Val Tyr Thr Arg Asp Val Ile Lys Asn Asn Pro Asp Ser Phe Arg Ile 
            420                 425                 430         


Phe Gly Pro Asp Glu Thr Ala Ser Asn Arg Leu Gln Ala Ala Tyr Glu 
        435                 440                 445             


Val Thr Asn Lys Gln Trp Asp Ala Gly Tyr Leu Ser Glu Leu Val Asp 
    450                 455                 460                 


Glu His Met Ala Val Thr Gly Gln Val Thr Glu Gln Leu Ser Glu His 
465                 470                 475                 480 


Gln Met Glu Gly Phe Leu Glu Ala Tyr Leu Leu Thr Gly Arg His Gly 
                485                 490                 495     


Ile Trp Ser Ser Tyr Glu Ser Phe Val His Val Ile Asp Ser Met Leu 
            500                 505                 510         


Asn Gln His Ala Lys Trp Leu Glu Ala Thr Val Arg Glu Ile Pro Trp 
        515                 520                 525             


Arg Lys Pro Ile Ser Ser Met Asn Leu Leu Val Ser Ser His Val Trp 
    530                 535                 540                 


Arg Gln Asp His Asn Gly Phe Ser His Gln Asp Pro Gly Val Thr Ser 
545                 550                 555                 560 


Val Leu Leu Asn Lys Thr Phe Asn Asn Asp His Val Ile Gly Ile Tyr 
                565                 570                 575     


Phe Pro Val Asp Ser Asn Met Leu Leu Ala Val Gly Glu Lys Val Tyr 
            580                 585                 590         


Lys Ser Thr Asn Met Ile Asn Ala Ile Phe Ala Gly Lys Gln Pro Ala 
        595                 600                 605             


Ala Thr Trp Leu Thr Leu Asp Glu Ala Arg Glu Glu Leu Glu Lys Gly 
    610                 615                 620                 


Ala Ala Glu Trp Lys Trp Ala Ser Asn Ala Lys Asn Asn Asp Glu Val 
625                 630                 635                 640 


Gln Val Val Leu Ala Gly Ile Gly Asp Val Pro Gln Gln Glu Leu Met 
                645                 650                 655     


Ala Ala Ala Asp Lys Leu Asn Lys Leu Gly Val Lys Phe Lys Val Val 
            660                 665                 670         


Asn Ile Val Asp Leu Leu Lys Leu Gln Ser Ala Lys Glu Asn Asn Glu 
        675                 680                 685             


Ala Leu Thr Asp Glu Glu Phe Thr Glu Leu Phe Thr Ala Asp Lys Pro 
    690                 695                 700                 


Val Leu Leu Ala Tyr His Ser Tyr Ala His Asp Val Arg Gly Leu Ile 
705                 710                 715                 720 


Phe Asp Arg Pro Asn His Asp Asn Phe Asn Val His Gly Tyr Lys Glu 
                725                 730                 735     


Gln Gly Ser Thr Thr Thr Pro Tyr Asp Met Val Arg Val Asn Asp Met 
            740                 745                 750         


Asp Arg Tyr Glu Leu Thr Ala Glu Ala Leu Arg Met Val Asp Ala Asp 
        755                 760                 765             


Lys Tyr Ala Asp Glu Ile Lys Lys Leu Glu Asp Phe Arg Leu Glu Ala 
    770                 775                 780                 


Phe Gln Phe Ala Val Asp Lys Gly Tyr Asp His Pro Asp Tyr Thr Asp 
785                 790                 795                 800 


Trp Val Trp Pro Gly Val Lys Thr Asp Lys Pro Gly Ala Val Thr Ala 
                805                 810                 815     


Thr Ala Ala Thr Ala Gly Asp Asn Glu Gly Ala Gly Pro Ala Arg Pro 
            820                 825                 830         


Ala Gly Leu Pro Pro Ala Thr Tyr Tyr Asp Ser Leu Ala Val Thr Ser 
        835                 840                 845             


Met Asp Leu Phe Glu Ser Leu Ala Gln Lys Ile Thr Gly Lys Asp Gln 
    850                 855                 860                 


Thr Ile Val Phe Pro Glu Gly Thr Glu Pro Arg Ile Val Gly Ala Ala 
865                 870                 875                 880 


Ala Arg Leu Ala Ala Asp Gly Leu Val Lys Pro Ile Val Leu Gly Ala 
                885                 890                 895     


Thr Asp Lys Val Gln Ala Val Ala Asn Asp Leu Asn Ala Asp Leu Thr 
            900                 905                 910         


Gly Val Gln Val Leu Asp Pro Ala Thr Tyr Pro Ala Glu Asp Lys Gln 
        915                 920                 925             


Ala Met Leu Asp Ala Leu Val Glu Arg Arg Lys Gly Lys Asn Thr Pro 
    930                 935                 940                 


Glu Gln Ala Ala Lys Met Leu Glu Asp Glu Asn Tyr Phe Gly Thr Met 
945                 950                 955                 960 


Leu Val Tyr Met Gly Lys Ala Asp Gly Met Val Ser Gly Ala Ile His 
                965                 970                 975     


Pro Thr Gly Asp Thr Val Arg Pro Ala Leu Gln Ile Ile Lys Thr Lys 
            980                 985                 990         


Pro Gly Ser His Arg Ile Ser Gly  Ala Phe Ile Met Gln  Lys Gly Glu 
        995                 1000                 1005             


Glu Arg  Tyr Val Phe Ala Asp  Cys Ala Ile Asn Ile  Asp Pro Asp 
    1010                 1015                 1020             


Ala Asp  Thr Leu Ala Glu Ile  Ala Thr Gln Ser Ala  Ala Thr Ala 
    1025                 1030                 1035             


Lys Val  Phe Asp Ile Asp Pro  Lys Val Ala Met Leu  Ser Phe Ser 
    1040                 1045                 1050             


Thr Lys  Gly Ser Ala Lys Gly  Glu Met Val Thr Lys  Val Gln Glu 
    1055                 1060                 1065             


Ala Thr  Ala Lys Ala Gln Ala  Ala Glu Pro Glu Leu  Ala Ile Asp 
    1070                 1075                 1080             


Gly Glu  Leu Gln Phe Asp Ala  Ala Phe Val Glu Lys  Val Gly Leu 
    1085                 1090                 1095             


Gln Lys  Ala Pro Gly Ser Lys  Val Ala Gly His Ala  Asn Val Phe 
    1100                 1105                 1110             


Val Phe  Pro Glu Leu Gln Ser  Gly Asn Ile Gly Tyr  Lys Ile Ala 
    1115                 1120                 1125             


Gln Arg  Phe Gly His Phe Glu  Ala Val Gly Pro Val  Leu Gln Gly 
    1130                 1135                 1140             


Leu Asn  Lys Pro Val Ser Asp  Leu Ser Arg Gly Cys  Ser Glu Glu 
    1145                 1150                 1155             


Asp Val  Tyr Lys Val Ala Ile  Ile Thr Ala Ala Gln  Gly Leu Ala 
    1160                 1165                 1170             


<210>  6
<211>  1157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6

Met Thr Ser Pro Val Ile Gly Thr Pro Trp Lys Lys Leu Asn Ala Pro 
1               5                   10                  15      


Val Ser Glu Ala Ala Ile Glu Gly Val Asp Lys Tyr Trp Arg Val Ala 
            20                  25                  30          


Asn Tyr Leu Ser Ile Gly Gln Ile Tyr Leu Arg Ser Asn Pro Leu Met 
        35                  40                  45              


Lys Glu Pro Phe Thr Arg Glu Asp Val Lys His Arg Leu Val Gly His 
    50                  55                  60                  


Trp Gly Thr Thr Pro Gly Leu Asn Phe Leu Ile Gly His Ile Asn Arg 
65                  70                  75                  80  


Phe Ile Ala Glu His Gln Gln Asn Thr Val Ile Ile Met Gly Pro Gly 
                85                  90                  95      


His Gly Gly Pro Ala Gly Thr Ala Gln Ser Tyr Leu Asp Gly Thr Tyr 
            100                 105                 110         


Thr Glu Tyr Tyr Pro Lys Ile Thr Lys Asp Glu Ala Gly Leu Gln Lys 
        115                 120                 125             


Phe Phe Arg Gln Phe Ser Tyr Pro Gly Gly Ile Pro Ser His Phe Ala 
    130                 135                 140                 


Pro Glu Thr Pro Gly Ser Ile His Glu Gly Gly Glu Leu Gly Tyr Ala 
145                 150                 155                 160 


Leu Ser His Ala Tyr Gly Ala Val Met Asn Asn Pro Ser Leu Phe Val 
                165                 170                 175     


Pro Ala Ile Val Gly Asp Gly Glu Ala Glu Thr Gly Pro Leu Ala Thr 
            180                 185                 190         


Gly Trp Gln Ser Asn Lys Leu Val Asn Pro Arg Thr Asp Gly Ile Val 
        195                 200                 205             


Leu Pro Ile Leu His Leu Asn Gly Tyr Lys Ile Ala Asn Pro Thr Ile 
    210                 215                 220                 


Leu Ser Arg Ile Ser Asp Glu Glu Leu His Glu Phe Phe His Gly Met 
225                 230                 235                 240 


Gly Tyr Glu Pro Tyr Glu Phe Val Ala Gly Phe Asp Asp Glu Asp His 
                245                 250                 255     


Met Ser Ile His Arg Arg Phe Ala Asp Met Phe Glu Thr Ile Phe Asp 
            260                 265                 270         


Glu Ile Cys Asp Ile Lys Ala Glu Ala Gln Thr Asn Asp Val Thr Arg 
        275                 280                 285             


Pro Phe Tyr Pro Met Ile Ile Phe Arg Thr Pro Lys Gly Trp Thr Cys 
    290                 295                 300                 


Pro Lys Phe Ile Asp Gly Lys Lys Thr Glu Gly Ser Trp Arg Ala His 
305                 310                 315                 320 


Gln Val Pro Leu Ala Ser Ala Arg Asp Thr Glu Ala His Phe Glu Val 
                325                 330                 335     


Leu Lys Asn Trp Leu Lys Ser Tyr Lys Pro Glu Glu Leu Phe Asn Glu 
            340                 345                 350         


Asp Gly Ser Ile Lys Glu Asp Val Leu Ser Phe Met Pro Gln Gly Glu 
        355                 360                 365             


Leu Arg Ile Gly Gln Asn Pro Asn Ala Asn Gly Gly Arg Ile Arg Glu 
    370                 375                 380                 


Asp Leu Lys Leu Pro Asn Leu Asp Asp Tyr Glu Val Lys Glu Val Lys 
385                 390                 395                 400 


Glu Phe Gly His Gly Trp Gly Gln Leu Glu Ala Thr Arg Arg Leu Gly 
                405                 410                 415     


Val Tyr Thr Arg Asp Val Ile Lys Asn Asn Pro Asp Ser Phe Arg Ile 
            420                 425                 430         


Phe Gly Pro Asp Glu Thr Ala Ser Asn Arg Leu Gln Ala Ala Tyr Glu 
        435                 440                 445             


Val Thr Asn Lys Gln Trp Asp Ala Gly Tyr Leu Ser Glu Leu Val Asp 
    450                 455                 460                 


Glu His Met Ala Val Thr Gly Gln Val Thr Glu Gln Leu Ser Glu His 
465                 470                 475                 480 


Gln Met Glu Gly Phe Leu Glu Ala Tyr Leu Leu Thr Gly Arg His Gly 
                485                 490                 495     


Ile Trp Ser Ser Tyr Glu Ser Phe Val His Val Ile Asp Ser Met Leu 
            500                 505                 510         


Asn Gln His Ala Lys Trp Leu Glu Ala Thr Val Arg Glu Ile Pro Trp 
        515                 520                 525             


Arg Lys Pro Ile Ser Ser Met Asn Leu Leu Val Ser Ser His Val Trp 
    530                 535                 540                 


Arg Gln Asp His Asn Gly Phe Ser His Gln Asp Pro Gly Val Thr Ser 
545                 550                 555                 560 


Val Leu Leu Asn Lys Thr Phe Asn Asn Asp His Val Ile Gly Ile Tyr 
                565                 570                 575     


Phe Pro Val Asp Ser Asn Met Leu Leu Ala Val Gly Glu Lys Val Tyr 
            580                 585                 590         


Lys Ser Thr Asn Met Ile Asn Ala Ile Phe Ala Gly Lys Gln Pro Ala 
        595                 600                 605             


Ala Thr Trp Leu Thr Leu Asp Glu Ala Arg Glu Glu Leu Glu Lys Gly 
    610                 615                 620                 


Ala Ala Glu Trp Lys Trp Ala Ser Asn Ala Lys Asn Asn Asp Glu Val 
625                 630                 635                 640 


Gln Val Val Leu Ala Gly Ile Gly Asp Val Pro Gln Gln Glu Leu Met 
                645                 650                 655     


Ala Ala Ala Asp Lys Leu Asn Lys Leu Gly Val Lys Phe Lys Val Val 
            660                 665                 670         


Asn Ile Val Asp Leu Leu Lys Leu Gln Ser Ala Lys Glu Asn Asn Glu 
        675                 680                 685             


Ala Leu Thr Asp Glu Glu Phe Thr Glu Leu Phe Thr Ala Asp Lys Pro 
    690                 695                 700                 


Val Leu Leu Ala Tyr His Ser Tyr Ala His Asp Val Arg Gly Leu Ile 
705                 710                 715                 720 


Phe Asp Arg Pro Asn His Asp Asn Phe Asn Val His Gly Tyr Lys Glu 
                725                 730                 735     


Gln Gly Ser Thr Thr Thr Pro Tyr Asp Met Val Arg Val Asn Asp Met 
            740                 745                 750         


Asp Arg Tyr Glu Leu Thr Ala Glu Ala Leu Arg Met Val Asp Ala Asp 
        755                 760                 765             


Lys Tyr Ala Asp Glu Ile Lys Lys Leu Glu Asp Phe Arg Leu Glu Ala 
    770                 775                 780                 


Phe Gln Phe Ala Val Asp Lys Gly Tyr Asp His Pro Asp Tyr Thr Asp 
785                 790                 795                 800 


Trp Val Trp Pro Gly Val Lys Thr Asp Lys Pro Gly Ala Val Thr Ala 
                805                 810                 815     


Thr Ala Ala Thr Ala Gly Asp Asn Glu Ala Gly Gly Gly Gly Thr Ser 
            820                 825                 830         


Met Asp Leu Phe Glu Ser Leu Ala Gln Lys Ile Thr Gly Lys Asp Gln 
        835                 840                 845             


Thr Ile Val Phe Pro Glu Gly Thr Glu Pro Arg Ile Val Gly Ala Ala 
    850                 855                 860                 


Ala Arg Leu Ala Ala Asp Gly Leu Val Lys Pro Ile Val Leu Gly Ala 
865                 870                 875                 880 


Thr Asp Lys Val Gln Ala Val Ala Asn Asp Leu Asn Ala Asp Leu Thr 
                885                 890                 895     


Gly Val Gln Val Leu Asp Pro Ala Thr Tyr Pro Ala Glu Asp Lys Gln 
            900                 905                 910         


Ala Met Leu Asp Ala Leu Val Glu Arg Arg Lys Gly Lys Asn Thr Pro 
        915                 920                 925             


Glu Gln Ala Ala Lys Met Leu Glu Asp Glu Asn Tyr Phe Gly Thr Met 
    930                 935                 940                 


Leu Val Tyr Met Gly Lys Ala Asp Gly Met Val Ser Gly Ala Ile His 
945                 950                 955                 960 


Pro Thr Gly Asp Thr Val Arg Pro Ala Leu Gln Ile Ile Lys Thr Lys 
                965                 970                 975     


Pro Gly Ser His Arg Ile Ser Gly Ala Phe Ile Met Gln Lys Gly Glu 
            980                 985                 990         


Glu Arg Tyr Val Phe Ala Asp Cys  Ala Ile Asn Ile Asp  Pro Asp Ala 
        995                 1000                 1005             


Asp Thr  Leu Ala Glu Ile Ala  Thr Gln Ser Ala Ala  Thr Ala Lys 
    1010                 1015                 1020             


Val Phe  Asp Ile Asp Pro Lys  Val Ala Met Leu Ser  Phe Ser Thr 
    1025                 1030                 1035             


Lys Gly  Ser Ala Lys Gly Glu  Met Val Thr Lys Val  Gln Glu Ala 
    1040                 1045                 1050             


Thr Ala  Lys Ala Gln Ala Ala  Glu Pro Glu Leu Ala  Ile Asp Gly 
    1055                 1060                 1065             


Glu Leu  Gln Phe Asp Ala Ala  Phe Val Glu Lys Val  Gly Leu Gln 
    1070                 1075                 1080             


Lys Ala  Pro Gly Ser Lys Val  Ala Gly His Ala Asn  Val Phe Val 
    1085                 1090                 1095             


Phe Pro  Glu Leu Gln Ser Gly  Asn Ile Gly Tyr Lys  Ile Ala Gln 
    1100                 1105                 1110             


Arg Phe  Gly His Phe Glu Ala  Val Gly Pro Val Leu  Gln Gly Leu 
    1115                 1120                 1125             


Asn Lys  Pro Val Ser Asp Leu  Ser Arg Gly Cys Ser  Glu Glu Asp 
    1130                 1135                 1140             


Val Tyr  Lys Val Ala Ile Ile  Thr Ala Ala Gln Gly  Leu Ala 
    1145                 1150                 1155         


