
                                SEQUENCE LISTING

<110> Seattle Children's Research Institute
      Jensen, Michael C.
      Ooi, Tracy
      Wei, Jia

<120> CHIMERIC TRANSCRIPTION FACTOR VARIANTS
  WITH AUGMENTED SENSITIVITY TO DRUG LIGAND INDUCTION OF
  TRANSGENE EXPRESSION IN MAMMMALIAN CELLS
  

<130> SCRI.118WO

<160> 124

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 862
<212> PRT
<213> Artificial Sequence

<220> 
<223> chimeric transcription factor composed of human
      subunits

<400> 1
Met Val Ser Lys Leu Ser Gln Leu Gln Thr Glu Leu Leu Ala Ala Leu
 1               5                  10                  15      
Leu Glu Ser Gly Leu Ser Lys Glu Ala Leu Ile Gln Ala Leu Gly Glu
            20                  25                  30          
Pro Gly Pro Tyr Leu Leu Ala Gly Glu Gly Pro Leu Asp Lys Gly Glu
        35                  40                  45              
Ser Cys Gly Gly Gly Arg Gly Glu Leu Ala Glu Leu Pro Asn Gly Leu
    50                  55                  60                  
Gly Glu Thr Arg Gly Ser Glu Asp Glu Thr Asp Asp Asp Gly Glu Asp
65                  70                  75                  80  
Phe Thr Pro Pro Ile Leu Lys Glu Leu Glu Asn Leu Ser Pro Glu Glu
                85                  90                  95      
Ala Ala His Gln Lys Ala Val Val Glu Thr Leu Leu Gln Glu Asp Pro
            100                 105                 110         
Trp Arg Val Ala Lys Met Val Lys Ser Tyr Leu Gln Gln His Asn Ile
        115                 120                 125             
Pro Gln Arg Glu Val Val Asp Thr Thr Gly Leu Asn Gln Ser His Leu
    130                 135                 140                 
Ser Gln His Leu Asn Lys Gly Thr Pro Met Lys Thr Gln Lys Arg Ala
145                 150                 155                 160 
Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln Arg Glu Val Ala Gln Gln
                165                 170                 175     
Phe Thr His Ala Gly Gln Gly Gly Leu Ile Glu Glu Pro Thr Gly Asp
            180                 185                 190         
Glu Leu Pro Thr Lys Lys Gly Arg Arg Asn Arg Phe Lys Trp Gly Pro
        195                 200                 205             
Ala Ser Gln Gln Ile Leu Phe Gln Ala Tyr Glu Arg Gln Lys Asn Pro
    210                 215                 220                 
Ser Lys Glu Glu Arg Glu Thr Leu Val Glu Glu Cys Asn Arg Ala Glu
225                 230                 235                 240 
Cys Ile Gln Arg Gly Val Ser Pro Ser Gln Ala Gln Gly Leu Gly Ser
                245                 250                 255     
Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg
            260                 265                 270         
Lys Glu Glu Ala Phe Arg His Lys Leu Ser Ala Gly Asp Met Arg Ala
        275                 280                 285             
Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn
    290                 295                 300                 
Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu
305                 310                 315                 320 
Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro
                325                 330                 335     
Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg
            340                 345                 350         
Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val
        355                 360                 365             
Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu
    370                 375                 380                 
Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly
385                 390                 395                 400 
Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys
                405                 410                 415     
Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser
            420                 425                 430         
Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu
        435                 440                 445             
Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser
    450                 455                 460                 
Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp
465                 470                 475                 480 
Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr
                485                 490                 495     
Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser
            500                 505                 510         
His Ile Arg His Met Ser Asn Lys Arg Met Glu His Leu Tyr Ser Met
        515                 520                 525             
Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu
    530                 535                 540                 
Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val
545                 550                 555                 560 
Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser
                565                 570                 575     
His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro
            580                 585                 590         
Ala Thr Val Glu Phe Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg
        595                 600                 605             
Ile Glu Glu Lys Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met
    610                 615                 620                 
Lys Lys Ser Pro Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg
625                 630                 635                 640 
Arg Ile Ala Val Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala
                645                 650                 655     
Pro Gln Pro Tyr Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp
            660                 665                 670         
Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser
        675                 680                 685             
Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro
    690                 695                 700                 
Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro
705                 710                 715                 720 
Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala
                725                 730                 735     
Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu
            740                 745                 750         
Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser
        755                 760                 765             
Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu
    770                 775                 780                 
Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr
785                 790                 795                 800 
Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr
                805                 810                 815     
Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro
            820                 825                 830         
Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile
        835                 840                 845             
Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser
    850                 855                 860         


<210> 2
<211> 862
<212> PRT
<213> Artificial Sequence

<220> 
<223> HEA3 transcription factor with one point mutation
      in the p65 domain

<400> 2
Met Val Ser Lys Leu Ser Gln Leu Gln Thr Glu Leu Leu Ala Ala Leu
 1               5                  10                  15      
Leu Glu Ser Gly Leu Ser Lys Glu Ala Leu Ile Gln Ala Leu Gly Glu
            20                  25                  30          
Pro Gly Pro Tyr Leu Leu Ala Gly Glu Gly Pro Leu Asp Lys Gly Glu
        35                  40                  45              
Ser Cys Gly Gly Gly Arg Gly Glu Leu Ala Glu Leu Pro Asn Gly Leu
    50                  55                  60                  
Gly Glu Thr Arg Gly Ser Glu Asp Glu Thr Asp Asp Asp Gly Glu Asp
65                  70                  75                  80  
Phe Thr Pro Pro Ile Leu Lys Glu Leu Glu Asn Leu Ser Pro Glu Glu
                85                  90                  95      
Ala Ala His Gln Lys Ala Val Val Glu Thr Leu Leu Gln Glu Asp Pro
            100                 105                 110         
Trp Arg Val Ala Lys Met Val Lys Ser Tyr Leu Gln Gln His Asn Ile
        115                 120                 125             
Pro Gln Arg Glu Val Val Asp Thr Thr Gly Leu Asn Gln Ser His Leu
    130                 135                 140                 
Ser Gln His Leu Asn Lys Gly Thr Pro Met Lys Thr Gln Lys Arg Ala
145                 150                 155                 160 
Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln Arg Glu Val Ala Gln Gln
                165                 170                 175     
Phe Thr His Ala Gly Gln Gly Gly Leu Ile Glu Glu Pro Thr Gly Asp
            180                 185                 190         
Glu Leu Pro Thr Lys Lys Gly Arg Arg Asn Arg Phe Lys Trp Gly Pro
        195                 200                 205             
Ala Ser Gln Gln Ile Leu Phe Gln Ala Tyr Glu Arg Gln Lys Asn Pro
    210                 215                 220                 
Ser Lys Glu Glu Arg Glu Thr Leu Val Glu Glu Cys Asn Arg Ala Glu
225                 230                 235                 240 
Cys Ile Gln Arg Gly Val Ser Pro Ser Gln Ala Gln Gly Leu Gly Ser
                245                 250                 255     
Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg
            260                 265                 270         
Lys Glu Glu Ala Phe Arg His Lys Leu Ser Ala Gly Asp Met Arg Ala
        275                 280                 285             
Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn
    290                 295                 300                 
Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu
305                 310                 315                 320 
Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro
                325                 330                 335     
Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg
            340                 345                 350         
Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val
        355                 360                 365             
Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu
    370                 375                 380                 
Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly
385                 390                 395                 400 
Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys
                405                 410                 415     
Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser
            420                 425                 430         
Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu
        435                 440                 445             
Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser
    450                 455                 460                 
Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp
465                 470                 475                 480 
Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr
                485                 490                 495     
Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser
            500                 505                 510         
His Ile Arg His Met Ser Asn Lys Arg Met Glu His Leu Tyr Ser Met
        515                 520                 525             
Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu
    530                 535                 540                 
Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val
545                 550                 555                 560 
Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser
                565                 570                 575     
His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro
            580                 585                 590         
Ala Thr Val Glu Phe Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg
        595                 600                 605             
Ile Glu Glu Lys Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met
    610                 615                 620                 
Lys Lys Ser Pro Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg
625                 630                 635                 640 
Arg Ile Ala Val Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala
                645                 650                 655     
Pro Gln Pro Tyr Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp
            660                 665                 670         
Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser
        675                 680                 685             
Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro
    690                 695                 700                 
Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro
705                 710                 715                 720 
Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala
                725                 730                 735     
Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu
            740                 745                 750         
Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser
        755                 760                 765             
Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu
    770                 775                 780                 
Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr
785                 790                 795                 800 
Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr
                805                 810                 815     
Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro
            820                 825                 830         
Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Glu Ser Ile
        835                 840                 845             
Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser
    850                 855                 860         


<210> 3
<211> 862
<212> PRT
<213> Artificial Sequence

<220> 
<223> HEA3 containing one point mutation in the p65
      domain

<400> 3
Met Val Ser Lys Leu Ser Gln Leu Gln Thr Glu Leu Leu Ala Ala Leu
 1               5                  10                  15      
Leu Glu Ser Gly Leu Ser Lys Glu Ala Leu Ile Gln Ala Leu Gly Glu
            20                  25                  30          
Pro Gly Pro Tyr Leu Leu Ala Gly Glu Gly Pro Leu Asp Lys Gly Glu
        35                  40                  45              
Ser Cys Gly Gly Gly Arg Gly Glu Leu Ala Glu Leu Pro Asn Gly Leu
    50                  55                  60                  
Gly Glu Thr Arg Gly Ser Glu Asp Glu Thr Asp Asp Asp Gly Glu Asp
65                  70                  75                  80  
Phe Thr Pro Pro Ile Leu Lys Glu Leu Glu Asn Leu Ser Pro Glu Glu
                85                  90                  95      
Ala Ala His Gln Lys Ala Val Val Glu Thr Leu Leu Gln Glu Asp Pro
            100                 105                 110         
Trp Arg Val Ala Lys Met Val Lys Ser Tyr Leu Gln Gln His Asn Ile
        115                 120                 125             
Pro Gln Arg Glu Val Val Asp Thr Thr Gly Leu Asn Gln Ser His Leu
    130                 135                 140                 
Ser Gln His Leu Asn Lys Gly Thr Pro Met Lys Thr Gln Lys Arg Ala
145                 150                 155                 160 
Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln Arg Glu Val Ala Gln Gln
                165                 170                 175     
Phe Thr His Ala Gly Gln Gly Gly Leu Ile Glu Glu Pro Thr Gly Asp
            180                 185                 190         
Glu Leu Pro Thr Lys Lys Gly Arg Arg Asn Arg Phe Lys Trp Gly Pro
        195                 200                 205             
Ala Ser Gln Gln Ile Leu Phe Gln Ala Tyr Glu Arg Gln Lys Asn Pro
    210                 215                 220                 
Ser Lys Glu Glu Arg Glu Thr Leu Val Glu Glu Cys Asn Arg Ala Glu
225                 230                 235                 240 
Cys Ile Gln Arg Gly Val Ser Pro Ser Gln Ala Gln Gly Leu Gly Ser
                245                 250                 255     
Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg
            260                 265                 270         
Lys Glu Glu Ala Phe Arg His Lys Leu Ser Ala Gly Asp Met Arg Ala
        275                 280                 285             
Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn
    290                 295                 300                 
Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu
305                 310                 315                 320 
Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro
                325                 330                 335     
Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg
            340                 345                 350         
Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val
        355                 360                 365             
Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu
    370                 375                 380                 
Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly
385                 390                 395                 400 
Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys
                405                 410                 415     
Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser
            420                 425                 430         
Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu
        435                 440                 445             
Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser
    450                 455                 460                 
Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp
465                 470                 475                 480 
Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr
                485                 490                 495     
Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser
            500                 505                 510         
His Ile Arg His Met Ser Asn Lys Arg Met Glu His Leu Tyr Ser Met
        515                 520                 525             
Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu
    530                 535                 540                 
Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val
545                 550                 555                 560 
Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser
                565                 570                 575     
His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro
            580                 585                 590         
Ala Thr Val Glu Phe Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg
        595                 600                 605             
Ile Glu Glu Lys Arg Lys Arg Thr Tyr Glu Thr Phe Gln Ser Ile Met
    610                 615                 620                 
Lys Lys Ser Pro Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg
625                 630                 635                 640 
Arg Ile Ala Val Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala
                645                 650                 655     
Pro Gln Pro Tyr Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp
            660                 665                 670         
Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser
        675                 680                 685             
Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro
    690                 695                 700                 
Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro
705                 710                 715                 720 
Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala
                725                 730                 735     
Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu
            740                 745                 750         
Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser
        755                 760                 765             
Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu
    770                 775                 780                 
Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr
785                 790                 795                 800 
Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr
                805                 810                 815     
Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro
            820                 825                 830         
Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile
        835                 840                 845             
Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser
    850                 855                 860         


<210> 4
<211> 862
<212> PRT
<213> Artificial Sequence

<220> 
<223> HEA4 comprising at least three mutations

<400> 4
Met Val Ser Lys Leu Ser Gln Leu Gln Thr Glu Leu Leu Ala Ala Leu
 1               5                  10                  15      
Leu Glu Ser Gly Leu Ser Lys Glu Ala Leu Ile Gln Ala Leu Gly Glu
            20                  25                  30          
Pro Gly Pro Tyr Leu Leu Ala Gly Glu Gly Pro Leu Asp Lys Gly Glu
        35                  40                  45              
Ser Cys Gly Gly Gly Arg Gly Glu Leu Ala Glu Leu Pro Asn Gly Leu
    50                  55                  60                  
Gly Glu Thr Arg Gly Ser Glu Asp Glu Thr Asp Asp Asp Gly Glu Asp
65                  70                  75                  80  
Phe Thr Pro Pro Ile Leu Lys Glu Leu Glu Asn Leu Ser Pro Glu Glu
                85                  90                  95      
Ala Ala His Gln Lys Ala Val Val Glu Thr Leu Leu Gln Glu Asp Pro
            100                 105                 110         
Trp Arg Val Ala Lys Met Val Lys Ser Tyr Leu Gln Gln His Asn Ile
        115                 120                 125             
Pro Gln Arg Glu Val Val Asp Thr Thr Gly Leu Asn Gln Ser His Leu
    130                 135                 140                 
Ser Gln His Leu Asn Lys Gly Thr Pro Met Lys Thr Gln Lys Arg Ala
145                 150                 155                 160 
Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln Arg Glu Val Ala Gln Gln
                165                 170                 175     
Phe Thr His Ala Gly Gln Gly Gly Leu Ile Glu Glu Pro Thr Gly Asp
            180                 185                 190         
Glu Leu Pro Thr Lys Lys Gly Arg Arg Asn Arg Phe Lys Trp Gly Pro
        195                 200                 205             
Ala Ser Gln Gln Ile Leu Phe Gln Ala Tyr Glu Arg Gln Lys Asn Pro
    210                 215                 220                 
Ser Lys Glu Glu Arg Glu Thr Leu Val Glu Glu Cys Asn Arg Ala Glu
225                 230                 235                 240 
Cys Ile Gln Arg Gly Val Ser Pro Ser Gln Ala Gln Gly Leu Gly Ser
                245                 250                 255     
Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg
            260                 265                 270         
Lys Glu Glu Ala Phe Arg His Lys Leu Ser Ala Gly Asp Met Arg Ala
        275                 280                 285             
Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn
    290                 295                 300                 
Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu
305                 310                 315                 320 
Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro
                325                 330                 335     
Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg
            340                 345                 350         
Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val
        355                 360                 365             
Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu
    370                 375                 380                 
Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Val
385                 390                 395                 400 
Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys
                405                 410                 415     
Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser
            420                 425                 430         
Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu
        435                 440                 445             
Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser
    450                 455                 460                 
Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp
465                 470                 475                 480 
Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr
                485                 490                 495     
Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser
            500                 505                 510         
His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met
        515                 520                 525             
Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Ala Ala
    530                 535                 540                 
Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val
545                 550                 555                 560 
Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser
                565                 570                 575     
His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro
            580                 585                 590         
Ala Thr Val Glu Phe Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg
        595                 600                 605             
Ile Glu Glu Lys Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met
    610                 615                 620                 
Lys Lys Ser Pro Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg
625                 630                 635                 640 
Arg Ile Ala Val Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala
                645                 650                 655     
Pro Gln Pro Tyr Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp
            660                 665                 670         
Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser
        675                 680                 685             
Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro
    690                 695                 700                 
Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro
705                 710                 715                 720 
Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala
                725                 730                 735     
Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu
            740                 745                 750         
Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser
        755                 760                 765             
Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu
    770                 775                 780                 
Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr
785                 790                 795                 800 
Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr
                805                 810                 815     
Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro
            820                 825                 830         
Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile
        835                 840                 845             
Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser
    850                 855                 860         


<210> 5
<211> 862
<212> PRT
<213> Artificial Sequence

<220> 
<223> HEA4 containing one point mutation in the p65
      domain

<400> 5
Met Val Ser Lys Leu Ser Gln Leu Gln Thr Glu Leu Leu Ala Ala Leu
 1               5                  10                  15      
Leu Glu Ser Gly Leu Ser Lys Glu Ala Leu Ile Gln Ala Leu Gly Glu
            20                  25                  30          
Pro Gly Pro Tyr Leu Leu Ala Gly Glu Gly Pro Leu Asp Lys Gly Glu
        35                  40                  45              
Ser Cys Gly Gly Gly Arg Gly Glu Leu Ala Glu Leu Pro Asn Gly Leu
    50                  55                  60                  
Gly Glu Thr Arg Gly Ser Glu Asp Glu Thr Asp Asp Asp Gly Glu Asp
65                  70                  75                  80  
Phe Thr Pro Pro Ile Leu Lys Glu Leu Glu Asn Leu Ser Pro Glu Glu
                85                  90                  95      
Ala Ala His Gln Lys Ala Val Val Glu Thr Leu Leu Gln Glu Asp Pro
            100                 105                 110         
Trp Arg Val Ala Lys Met Val Lys Ser Tyr Leu Gln Gln His Asn Ile
        115                 120                 125             
Pro Gln Arg Glu Val Val Asp Thr Thr Gly Leu Asn Gln Ser His Leu
    130                 135                 140                 
Ser Gln His Leu Asn Lys Gly Thr Pro Met Lys Thr Gln Lys Arg Ala
145                 150                 155                 160 
Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln Arg Glu Val Ala Gln Gln
                165                 170                 175     
Phe Thr His Ala Gly Gln Gly Gly Leu Ile Glu Glu Pro Thr Gly Asp
            180                 185                 190         
Glu Leu Pro Thr Lys Lys Gly Arg Arg Asn Arg Phe Lys Trp Gly Pro
        195                 200                 205             
Ala Ser Gln Gln Ile Leu Phe Gln Ala Tyr Glu Arg Gln Lys Asn Pro
    210                 215                 220                 
Ser Lys Glu Glu Arg Glu Thr Leu Val Glu Glu Cys Asn Arg Ala Glu
225                 230                 235                 240 
Cys Ile Gln Arg Gly Val Ser Pro Ser Gln Ala Gln Gly Leu Gly Ser
                245                 250                 255     
Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg
            260                 265                 270         
Lys Glu Glu Ala Phe Arg His Lys Leu Ser Ala Gly Asp Met Arg Ala
        275                 280                 285             
Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn
    290                 295                 300                 
Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu
305                 310                 315                 320 
Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro
                325                 330                 335     
Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg
            340                 345                 350         
Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val
        355                 360                 365             
Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu
    370                 375                 380                 
Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Val
385                 390                 395                 400 
Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys
                405                 410                 415     
Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser
            420                 425                 430         
Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu
        435                 440                 445             
Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser
    450                 455                 460                 
Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp
465                 470                 475                 480 
Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr
                485                 490                 495     
Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser
            500                 505                 510         
His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met
        515                 520                 525             
Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Ala Ala
    530                 535                 540                 
Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val
545                 550                 555                 560 
Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser
                565                 570                 575     
His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro
            580                 585                 590         
Ala Thr Val Glu Phe Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg
        595                 600                 605             
Ile Glu Glu Lys Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met
    610                 615                 620                 
Lys Lys Ser Pro Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg
625                 630                 635                 640 
Arg Ile Ala Val Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala
                645                 650                 655     
Pro Gln Pro Tyr Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp
            660                 665                 670         
Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser
        675                 680                 685             
Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro
    690                 695                 700                 
Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro
705                 710                 715                 720 
Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala
                725                 730                 735     
Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu
            740                 745                 750         
Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser
        755                 760                 765             
Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu
    770                 775                 780                 
Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr
785                 790                 795                 800 
Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr
                805                 810                 815     
Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro
            820                 825                 830         
Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Glu Ser Ile
        835                 840                 845             
Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser
    850                 855                 860         


<210> 6
<211> 862
<212> PRT
<213> Artificial Sequence

<220> 
<223> HEA4 containing one point mutation in the p65
      domain

<400> 6
Met Val Ser Lys Leu Ser Gln Leu Gln Thr Glu Leu Leu Ala Ala Leu
 1               5                  10                  15      
Leu Glu Ser Gly Leu Ser Lys Glu Ala Leu Ile Gln Ala Leu Gly Glu
            20                  25                  30          
Pro Gly Pro Tyr Leu Leu Ala Gly Glu Gly Pro Leu Asp Lys Gly Glu
        35                  40                  45              
Ser Cys Gly Gly Gly Arg Gly Glu Leu Ala Glu Leu Pro Asn Gly Leu
    50                  55                  60                  
Gly Glu Thr Arg Gly Ser Glu Asp Glu Thr Asp Asp Asp Gly Glu Asp
65                  70                  75                  80  
Phe Thr Pro Pro Ile Leu Lys Glu Leu Glu Asn Leu Ser Pro Glu Glu
                85                  90                  95      
Ala Ala His Gln Lys Ala Val Val Glu Thr Leu Leu Gln Glu Asp Pro
            100                 105                 110         
Trp Arg Val Ala Lys Met Val Lys Ser Tyr Leu Gln Gln His Asn Ile
        115                 120                 125             
Pro Gln Arg Glu Val Val Asp Thr Thr Gly Leu Asn Gln Ser His Leu
    130                 135                 140                 
Ser Gln His Leu Asn Lys Gly Thr Pro Met Lys Thr Gln Lys Arg Ala
145                 150                 155                 160 
Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln Arg Glu Val Ala Gln Gln
                165                 170                 175     
Phe Thr His Ala Gly Gln Gly Gly Leu Ile Glu Glu Pro Thr Gly Asp
            180                 185                 190         
Glu Leu Pro Thr Lys Lys Gly Arg Arg Asn Arg Phe Lys Trp Gly Pro
        195                 200                 205             
Ala Ser Gln Gln Ile Leu Phe Gln Ala Tyr Glu Arg Gln Lys Asn Pro
    210                 215                 220                 
Ser Lys Glu Glu Arg Glu Thr Leu Val Glu Glu Cys Asn Arg Ala Glu
225                 230                 235                 240 
Cys Ile Gln Arg Gly Val Ser Pro Ser Gln Ala Gln Gly Leu Gly Ser
                245                 250                 255     
Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg
            260                 265                 270         
Lys Glu Glu Ala Phe Arg His Lys Leu Ser Ala Gly Asp Met Arg Ala
        275                 280                 285             
Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn
    290                 295                 300                 
Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu
305                 310                 315                 320 
Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro
                325                 330                 335     
Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg
            340                 345                 350         
Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val
        355                 360                 365             
Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu
    370                 375                 380                 
Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Val
385                 390                 395                 400 
Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys
                405                 410                 415     
Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser
            420                 425                 430         
Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu
        435                 440                 445             
Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser
    450                 455                 460                 
Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp
465                 470                 475                 480 
Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr
                485                 490                 495     
Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser
            500                 505                 510         
His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met
        515                 520                 525             
Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Ala Ala
    530                 535                 540                 
Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val
545                 550                 555                 560 
Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser
                565                 570                 575     
His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro
            580                 585                 590         
Ala Thr Val Glu Phe Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg
        595                 600                 605             
Ile Glu Glu Lys Arg Lys Arg Thr Tyr Glu Thr Phe Gln Ser Ile Met
    610                 615                 620                 
Lys Lys Ser Pro Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg
625                 630                 635                 640 
Arg Ile Ala Val Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala
                645                 650                 655     
Pro Gln Pro Tyr Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp
            660                 665                 670         
Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser
        675                 680                 685             
Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro
    690                 695                 700                 
Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro
705                 710                 715                 720 
Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala
                725                 730                 735     
Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu
            740                 745                 750         
Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser
        755                 760                 765             
Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu
    770                 775                 780                 
Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr
785                 790                 795                 800 
Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr
                805                 810                 815     
Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro
            820                 825                 830         
Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile
        835                 840                 845             
Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser
    850                 855                 860         


<210> 7
<211> 862
<212> PRT
<213> Artificial Sequence

<220> 
<223> HEA4 containing two point mutations in the p65
      domain that enhance transcriptional activity

<400> 7
Met Val Ser Lys Leu Ser Gln Leu Gln Thr Glu Leu Leu Ala Ala Leu
 1               5                  10                  15      
Leu Glu Ser Gly Leu Ser Lys Glu Ala Leu Ile Gln Ala Leu Gly Glu
            20                  25                  30          
Pro Gly Pro Tyr Leu Leu Ala Gly Glu Gly Pro Leu Asp Lys Gly Glu
        35                  40                  45              
Ser Cys Gly Gly Gly Arg Gly Glu Leu Ala Glu Leu Pro Asn Gly Leu
    50                  55                  60                  
Gly Glu Thr Arg Gly Ser Glu Asp Glu Thr Asp Asp Asp Gly Glu Asp
65                  70                  75                  80  
Phe Thr Pro Pro Ile Leu Lys Glu Leu Glu Asn Leu Ser Pro Glu Glu
                85                  90                  95      
Ala Ala His Gln Lys Ala Val Val Glu Thr Leu Leu Gln Glu Asp Pro
            100                 105                 110         
Trp Arg Val Ala Lys Met Val Lys Ser Tyr Leu Gln Gln His Asn Ile
        115                 120                 125             
Pro Gln Arg Glu Val Val Asp Thr Thr Gly Leu Asn Gln Ser His Leu
    130                 135                 140                 
Ser Gln His Leu Asn Lys Gly Thr Pro Met Lys Thr Gln Lys Arg Ala
145                 150                 155                 160 
Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln Arg Glu Val Ala Gln Gln
                165                 170                 175     
Phe Thr His Ala Gly Gln Gly Gly Leu Ile Glu Glu Pro Thr Gly Asp
            180                 185                 190         
Glu Leu Pro Thr Lys Lys Gly Arg Arg Asn Arg Phe Lys Trp Gly Pro
        195                 200                 205             
Ala Ser Gln Gln Ile Leu Phe Gln Ala Tyr Glu Arg Gln Lys Asn Pro
    210                 215                 220                 
Ser Lys Glu Glu Arg Glu Thr Leu Val Glu Glu Cys Asn Arg Ala Glu
225                 230                 235                 240 
Cys Ile Gln Arg Gly Val Ser Pro Ser Gln Ala Gln Gly Leu Gly Ser
                245                 250                 255     
Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg
            260                 265                 270         
Lys Glu Glu Ala Phe Arg His Lys Leu Ser Ala Gly Asp Met Arg Ala
        275                 280                 285             
Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn
    290                 295                 300                 
Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu
305                 310                 315                 320 
Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro
                325                 330                 335     
Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg
            340                 345                 350         
Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val
        355                 360                 365             
Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu
    370                 375                 380                 
Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Val
385                 390                 395                 400 
Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys
                405                 410                 415     
Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser
            420                 425                 430         
Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu
        435                 440                 445             
Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser
    450                 455                 460                 
Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp
465                 470                 475                 480 
Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr
                485                 490                 495     
Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser
            500                 505                 510         
His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met
        515                 520                 525             
Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Ala Ala
    530                 535                 540                 
Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val
545                 550                 555                 560 
Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser
                565                 570                 575     
His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro
            580                 585                 590         
Ala Thr Val Glu Phe Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg
        595                 600                 605             
Ile Glu Glu Lys Arg Lys Arg Thr Tyr Glu Thr Phe Gln Ser Ile Met
    610                 615                 620                 
Lys Lys Ser Pro Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg
625                 630                 635                 640 
Arg Ile Ala Val Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala
                645                 650                 655     
Pro Gln Pro Tyr Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp
            660                 665                 670         
Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser
        675                 680                 685             
Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro
    690                 695                 700                 
Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro
705                 710                 715                 720 
Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala
                725                 730                 735     
Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu
            740                 745                 750         
Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser
        755                 760                 765             
Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu
    770                 775                 780                 
Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr
785                 790                 795                 800 
Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr
                805                 810                 815     
Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro
            820                 825                 830         
Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Glu Ser Ile
        835                 840                 845             
Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser
    850                 855                 860         


<210> 8
<211> 862
<212> PRT
<213> Artificial Sequence

<220> 
<223> HEA3 containing three point mutations in the
      ER-LBD

<400> 8
Met Val Ser Lys Leu Ser Gln Leu Gln Thr Glu Leu Leu Ala Ala Leu
 1               5                  10                  15      
Leu Glu Ser Gly Leu Ser Lys Glu Ala Leu Ile Gln Ala Leu Gly Glu
            20                  25                  30          
Pro Gly Pro Tyr Leu Leu Ala Gly Glu Gly Pro Leu Asp Lys Gly Glu
        35                  40                  45              
Ser Cys Gly Gly Gly Arg Gly Glu Leu Ala Glu Leu Pro Asn Gly Leu
    50                  55                  60                  
Gly Glu Thr Arg Gly Ser Glu Asp Glu Thr Asp Asp Asp Gly Glu Asp
65                  70                  75                  80  
Phe Thr Pro Pro Ile Leu Lys Glu Leu Glu Asn Leu Ser Pro Glu Glu
                85                  90                  95      
Ala Ala His Gln Lys Ala Val Val Glu Thr Leu Leu Gln Glu Asp Pro
            100                 105                 110         
Trp Arg Val Ala Lys Met Val Lys Ser Tyr Leu Gln Gln His Asn Ile
        115                 120                 125             
Pro Gln Arg Glu Val Val Asp Thr Thr Gly Leu Asn Gln Ser His Leu
    130                 135                 140                 
Ser Gln His Leu Asn Lys Gly Thr Pro Met Lys Thr Gln Lys Arg Ala
145                 150                 155                 160 
Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln Arg Glu Val Ala Gln Gln
                165                 170                 175     
Phe Thr His Ala Gly Gln Gly Gly Leu Ile Glu Glu Pro Thr Gly Asp
            180                 185                 190         
Glu Leu Pro Thr Lys Lys Gly Arg Arg Asn Arg Phe Lys Trp Gly Pro
        195                 200                 205             
Ala Ser Gln Gln Ile Leu Phe Gln Ala Tyr Glu Arg Gln Lys Asn Pro
    210                 215                 220                 
Ser Lys Glu Glu Arg Glu Thr Leu Val Glu Glu Cys Asn Arg Ala Glu
225                 230                 235                 240 
Cys Ile Gln Arg Gly Val Ser Pro Ser Gln Ala Gln Gly Leu Gly Ser
                245                 250                 255     
Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg
            260                 265                 270         
Lys Glu Glu Ala Phe Arg His Lys Leu Ser Ala Gly Asp Met Arg Ala
        275                 280                 285             
Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn
    290                 295                 300                 
Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu
305                 310                 315                 320 
Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro
                325                 330                 335     
Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg
            340                 345                 350         
Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val
        355                 360                 365             
Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Met
    370                 375                 380                 
Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly
385                 390                 395                 400 
Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys
                405                 410                 415     
Cys Val Glu Gly Gly Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser
            420                 425                 430         
Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu
        435                 440                 445             
Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser
    450                 455                 460                 
Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp
465                 470                 475                 480 
Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr
                485                 490                 495     
Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser
            500                 505                 510         
His Ile Arg His Met Ser Asn Lys Arg Met Glu His Leu Tyr Ser Met
        515                 520                 525             
Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu
    530                 535                 540                 
Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val
545                 550                 555                 560 
Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser
                565                 570                 575     
His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro
            580                 585                 590         
Ala Thr Val Glu Phe Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg
        595                 600                 605             
Ile Glu Glu Lys Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met
    610                 615                 620                 
Lys Lys Ser Pro Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg
625                 630                 635                 640 
Arg Ile Ala Val Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala
                645                 650                 655     
Pro Gln Pro Tyr Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp
            660                 665                 670         
Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser
        675                 680                 685             
Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro
    690                 695                 700                 
Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro
705                 710                 715                 720 
Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala
                725                 730                 735     
Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu
            740                 745                 750         
Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser
        755                 760                 765             
Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu
    770                 775                 780                 
Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr
785                 790                 795                 800 
Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr
                805                 810                 815     
Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro
            820                 825                 830         
Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile
        835                 840                 845             
Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser
    850                 855                 860         


<210> 9
<211> 862
<212> PRT
<213> Artificial Sequence

<220> 
<223> CMP8-HEA3 containing one point mutation in the p65
      domain

<400> 9
Met Val Ser Lys Leu Ser Gln Leu Gln Thr Glu Leu Leu Ala Ala Leu
 1               5                  10                  15      
Leu Glu Ser Gly Leu Ser Lys Glu Ala Leu Ile Gln Ala Leu Gly Glu
            20                  25                  30          
Pro Gly Pro Tyr Leu Leu Ala Gly Glu Gly Pro Leu Asp Lys Gly Glu
        35                  40                  45              
Ser Cys Gly Gly Gly Arg Gly Glu Leu Ala Glu Leu Pro Asn Gly Leu
    50                  55                  60                  
Gly Glu Thr Arg Gly Ser Glu Asp Glu Thr Asp Asp Asp Gly Glu Asp
65                  70                  75                  80  
Phe Thr Pro Pro Ile Leu Lys Glu Leu Glu Asn Leu Ser Pro Glu Glu
                85                  90                  95      
Ala Ala His Gln Lys Ala Val Val Glu Thr Leu Leu Gln Glu Asp Pro
            100                 105                 110         
Trp Arg Val Ala Lys Met Val Lys Ser Tyr Leu Gln Gln His Asn Ile
        115                 120                 125             
Pro Gln Arg Glu Val Val Asp Thr Thr Gly Leu Asn Gln Ser His Leu
    130                 135                 140                 
Ser Gln His Leu Asn Lys Gly Thr Pro Met Lys Thr Gln Lys Arg Ala
145                 150                 155                 160 
Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln Arg Glu Val Ala Gln Gln
                165                 170                 175     
Phe Thr His Ala Gly Gln Gly Gly Leu Ile Glu Glu Pro Thr Gly Asp
            180                 185                 190         
Glu Leu Pro Thr Lys Lys Gly Arg Arg Asn Arg Phe Lys Trp Gly Pro
        195                 200                 205             
Ala Ser Gln Gln Ile Leu Phe Gln Ala Tyr Glu Arg Gln Lys Asn Pro
    210                 215                 220                 
Ser Lys Glu Glu Arg Glu Thr Leu Val Glu Glu Cys Asn Arg Ala Glu
225                 230                 235                 240 
Cys Ile Gln Arg Gly Val Ser Pro Ser Gln Ala Gln Gly Leu Gly Ser
                245                 250                 255     
Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg
            260                 265                 270         
Lys Glu Glu Ala Phe Arg His Lys Leu Ser Ala Gly Asp Met Arg Ala
        275                 280                 285             
Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn
    290                 295                 300                 
Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu
305                 310                 315                 320 
Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro
                325                 330                 335     
Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg
            340                 345                 350         
Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val
        355                 360                 365             
Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Met
    370                 375                 380                 
Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly
385                 390                 395                 400 
Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys
                405                 410                 415     
Cys Val Glu Gly Gly Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser
            420                 425                 430         
Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu
        435                 440                 445             
Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser
    450                 455                 460                 
Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp
465                 470                 475                 480 
Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr
                485                 490                 495     
Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser
            500                 505                 510         
His Ile Arg His Met Ser Asn Lys Arg Met Glu His Leu Tyr Ser Met
        515                 520                 525             
Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu
    530                 535                 540                 
Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val
545                 550                 555                 560 
Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser
                565                 570                 575     
His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro
            580                 585                 590         
Ala Thr Val Glu Phe Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg
        595                 600                 605             
Ile Glu Glu Lys Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met
    610                 615                 620                 
Lys Lys Ser Pro Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg
625                 630                 635                 640 
Arg Ile Ala Val Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala
                645                 650                 655     
Pro Gln Pro Tyr Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp
            660                 665                 670         
Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser
        675                 680                 685             
Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro
    690                 695                 700                 
Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro
705                 710                 715                 720 
Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala
                725                 730                 735     
Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu
            740                 745                 750         
Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser
        755                 760                 765             
Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu
    770                 775                 780                 
Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr
785                 790                 795                 800 
Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr
                805                 810                 815     
Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro
            820                 825                 830         
Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Glu Ser Ile
        835                 840                 845             
Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser
    850                 855                 860         


<210> 10
<211> 862
<212> PRT
<213> Artificial Sequence

<220> 
<223> CMP8-HEA3 containing one point mutation in the p65
      domain

<400> 10
Met Val Ser Lys Leu Ser Gln Leu Gln Thr Glu Leu Leu Ala Ala Leu
 1               5                  10                  15      
Leu Glu Ser Gly Leu Ser Lys Glu Ala Leu Ile Gln Ala Leu Gly Glu
            20                  25                  30          
Pro Gly Pro Tyr Leu Leu Ala Gly Glu Gly Pro Leu Asp Lys Gly Glu
        35                  40                  45              
Ser Cys Gly Gly Gly Arg Gly Glu Leu Ala Glu Leu Pro Asn Gly Leu
    50                  55                  60                  
Gly Glu Thr Arg Gly Ser Glu Asp Glu Thr Asp Asp Asp Gly Glu Asp
65                  70                  75                  80  
Phe Thr Pro Pro Ile Leu Lys Glu Leu Glu Asn Leu Ser Pro Glu Glu
                85                  90                  95      
Ala Ala His Gln Lys Ala Val Val Glu Thr Leu Leu Gln Glu Asp Pro
            100                 105                 110         
Trp Arg Val Ala Lys Met Val Lys Ser Tyr Leu Gln Gln His Asn Ile
        115                 120                 125             
Pro Gln Arg Glu Val Val Asp Thr Thr Gly Leu Asn Gln Ser His Leu
    130                 135                 140                 
Ser Gln His Leu Asn Lys Gly Thr Pro Met Lys Thr Gln Lys Arg Ala
145                 150                 155                 160 
Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln Arg Glu Val Ala Gln Gln
                165                 170                 175     
Phe Thr His Ala Gly Gln Gly Gly Leu Ile Glu Glu Pro Thr Gly Asp
            180                 185                 190         
Glu Leu Pro Thr Lys Lys Gly Arg Arg Asn Arg Phe Lys Trp Gly Pro
        195                 200                 205             
Ala Ser Gln Gln Ile Leu Phe Gln Ala Tyr Glu Arg Gln Lys Asn Pro
    210                 215                 220                 
Ser Lys Glu Glu Arg Glu Thr Leu Val Glu Glu Cys Asn Arg Ala Glu
225                 230                 235                 240 
Cys Ile Gln Arg Gly Val Ser Pro Ser Gln Ala Gln Gly Leu Gly Ser
                245                 250                 255     
Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg
            260                 265                 270         
Lys Glu Glu Ala Phe Arg His Lys Leu Ser Ala Gly Asp Met Arg Ala
        275                 280                 285             
Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn
    290                 295                 300                 
Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu
305                 310                 315                 320 
Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro
                325                 330                 335     
Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg
            340                 345                 350         
Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val
        355                 360                 365             
Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Met
    370                 375                 380                 
Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly
385                 390                 395                 400 
Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys
                405                 410                 415     
Cys Val Glu Gly Gly Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser
            420                 425                 430         
Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu
        435                 440                 445             
Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser
    450                 455                 460                 
Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp
465                 470                 475                 480 
Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr
                485                 490                 495     
Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser
            500                 505                 510         
His Ile Arg His Met Ser Asn Lys Arg Met Glu His Leu Tyr Ser Met
        515                 520                 525             
Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu
    530                 535                 540                 
Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val
545                 550                 555                 560 
Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser
                565                 570                 575     
His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro
            580                 585                 590         
Ala Thr Val Glu Phe Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg
        595                 600                 605             
Ile Glu Glu Lys Arg Lys Arg Thr Tyr Glu Thr Phe Gln Ser Ile Met
    610                 615                 620                 
Lys Lys Ser Pro Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg
625                 630                 635                 640 
Arg Ile Ala Val Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala
                645                 650                 655     
Pro Gln Pro Tyr Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp
            660                 665                 670         
Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser
        675                 680                 685             
Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro
    690                 695                 700                 
Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro
705                 710                 715                 720 
Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala
                725                 730                 735     
Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu
            740                 745                 750         
Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser
        755                 760                 765             
Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu
    770                 775                 780                 
Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr
785                 790                 795                 800 
Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr
                805                 810                 815     
Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro
            820                 825                 830         
Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile
        835                 840                 845             
Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser
    850                 855                 860         


<210> 11
<211> 862
<212> PRT
<213> Artificial Sequence

<220> 
<223> CMP8-HEA3 containing two point mutations in the
      p65 domain

<400> 11
Met Val Ser Lys Leu Ser Gln Leu Gln Thr Glu Leu Leu Ala Ala Leu
 1               5                  10                  15      
Leu Glu Ser Gly Leu Ser Lys Glu Ala Leu Ile Gln Ala Leu Gly Glu
            20                  25                  30          
Pro Gly Pro Tyr Leu Leu Ala Gly Glu Gly Pro Leu Asp Lys Gly Glu
        35                  40                  45              
Ser Cys Gly Gly Gly Arg Gly Glu Leu Ala Glu Leu Pro Asn Gly Leu
    50                  55                  60                  
Gly Glu Thr Arg Gly Ser Glu Asp Glu Thr Asp Asp Asp Gly Glu Asp
65                  70                  75                  80  
Phe Thr Pro Pro Ile Leu Lys Glu Leu Glu Asn Leu Ser Pro Glu Glu
                85                  90                  95      
Ala Ala His Gln Lys Ala Val Val Glu Thr Leu Leu Gln Glu Asp Pro
            100                 105                 110         
Trp Arg Val Ala Lys Met Val Lys Ser Tyr Leu Gln Gln His Asn Ile
        115                 120                 125             
Pro Gln Arg Glu Val Val Asp Thr Thr Gly Leu Asn Gln Ser His Leu
    130                 135                 140                 
Ser Gln His Leu Asn Lys Gly Thr Pro Met Lys Thr Gln Lys Arg Ala
145                 150                 155                 160 
Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln Arg Glu Val Ala Gln Gln
                165                 170                 175     
Phe Thr His Ala Gly Gln Gly Gly Leu Ile Glu Glu Pro Thr Gly Asp
            180                 185                 190         
Glu Leu Pro Thr Lys Lys Gly Arg Arg Asn Arg Phe Lys Trp Gly Pro
        195                 200                 205             
Ala Ser Gln Gln Ile Leu Phe Gln Ala Tyr Glu Arg Gln Lys Asn Pro
    210                 215                 220                 
Ser Lys Glu Glu Arg Glu Thr Leu Val Glu Glu Cys Asn Arg Ala Glu
225                 230                 235                 240 
Cys Ile Gln Arg Gly Val Ser Pro Ser Gln Ala Gln Gly Leu Gly Ser
                245                 250                 255     
Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg
            260                 265                 270         
Lys Glu Glu Ala Phe Arg His Lys Leu Ser Ala Gly Asp Met Arg Ala
        275                 280                 285             
Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn
    290                 295                 300                 
Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu
305                 310                 315                 320 
Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro
                325                 330                 335     
Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg
            340                 345                 350         
Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val
        355                 360                 365             
Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Met
    370                 375                 380                 
Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly
385                 390                 395                 400 
Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys
                405                 410                 415     
Cys Val Glu Gly Gly Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser
            420                 425                 430         
Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu
        435                 440                 445             
Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser
    450                 455                 460                 
Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp
465                 470                 475                 480 
Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr
                485                 490                 495     
Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser
            500                 505                 510         
His Ile Arg His Met Ser Asn Lys Arg Met Glu His Leu Tyr Ser Met
        515                 520                 525             
Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu
    530                 535                 540                 
Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val
545                 550                 555                 560 
Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser
                565                 570                 575     
His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro
            580                 585                 590         
Ala Thr Val Glu Phe Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg
        595                 600                 605             
Ile Glu Glu Lys Arg Lys Arg Thr Tyr Glu Thr Phe Gln Ser Ile Met
    610                 615                 620                 
Lys Lys Ser Pro Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg
625                 630                 635                 640 
Arg Ile Ala Val Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala
                645                 650                 655     
Pro Gln Pro Tyr Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp
            660                 665                 670         
Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser
        675                 680                 685             
Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro
    690                 695                 700                 
Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro
705                 710                 715                 720 
Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala
                725                 730                 735     
Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu
            740                 745                 750         
Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser
        755                 760                 765             
Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu
    770                 775                 780                 
Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr
785                 790                 795                 800 
Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr
                805                 810                 815     
Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro
            820                 825                 830         
Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Glu Ser Ile
        835                 840                 845             
Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser
    850                 855                 860         


<210> 12
<211> 2586
<212> DNA
<213> Unknown

<220> 
<223> variant of the wild type HEA3 transcription factor

<400> 12
atggtgtcca agctgtccca gctgcagaca gaactgctgg cagcactgct ggaaagcggc 60
ctgagcaaag aggccctgat tcaggcactc ggcgaacctg gaccttatct gctcgctggc 120
gaaggccctc tggataaggg cgagagctgt ggcggaggaa gaggagagct ggccgagctg 180
cctaacggcc tgggcgagac aagaggcagc gaggacgaga cagacgacga cggcgaggac 240
ttcacccccc ccatcctgaa agagctggaa aacctgagcc ccgaggaagc cgcccaccag 300
aaagccgtgg tggagacact gctgcaggaa gatccctggc gggtcgccaa gatggtcaag 360
agctacctgc agcagcacaa catcccccag cgggaggtgg tggacaccac cggcctgaac 420
cagagccacc tgagccagca cctgaacaag ggcaccccca tgaaaaccca gaagagagcc 480
gccctgtaca cttggtacgt gcggaagcag agagaggtgg cccagcagtt tacacacgcc 540
ggccagggcg gcctgatcga ggaacctacc ggcgacgagc tgcccaccaa gaagggcaga 600
cggaaccggt ttaagtgggg ccctgcatct cagcagatcc tgttccaggc ctacgagcgg 660
cagaagaacc ccagcaaaga ggaacgggag acactggtgg aagagtgcaa ccgggccgag 720
tgcatccaga gaggcgtgag cccttctcag gctcagggcc tcggcagcaa tctggtcacc 780
gaagtgcggg tgtacaattg gttcgccaac cggcggaaag aggaagcctt ccggcacaag 840
ctgtctgctg gcgatatgag agccgccaac ctgtggccca gccccctgat gatcaagcgg 900
agcaagaaga acagcctggc cctgagcctg accgccgatc agatggtgtc cgctctgctg 960
gacgccgagc cccctatcct gtacagcgag tacgacccca ccagaccctt cagcgaggcc 1020
agcatgatgg gcctgctgac caacctggcc gaccgggagc tggtgcacat gatcaactgg 1080
gccaagcggg tgcccggctt cgtggacctg accctgcacg accaggtcca cctgctggaa 1140
tgtgcctggc tggaaatcct gatgatcggc ctcgtgtgga gaagcatgga acaccccggc 1200
aagctgctgt tcgcccccaa cctgctcctg gaccggaacc agggaaagtg cgtggagggc 1260
atggtggaga tcttcgacat gctgctggcc acctccagcc ggttccggat gatgaacctg 1320
cagggcgagg aattcgtgtg cctgaagtcc atcatcctgc tgaacagcgg cgtgtacacc 1380
ttcctgtcat ccaccctgaa gtccctggaa gagaaggacc acatccaccg ggtgctggac 1440
aagatcaccg acaccctgat ccacctgatg gccaaggctg gcctgacact ccagcagcag 1500
caccagagac tggcccagct gctgctgatc ctgagccaca tccggcacat gagcaacaag 1560
cggatggaac acctgtacag catgaagtgc aagaacgtgg tgcccctgta cgacctgctg 1620
ctcgagatgc tggatgccca cagactgcac gcccctacaa gcagaggcgg agccagcgtg 1680
gaggaaaccg accagtctca cctggccacc gccggcagca caagcagcca cagcctgcag 1740
aagtactaca tcaccggcga ggccgaggga ttccctgcca ccgtggagtt ccagtacctg 1800
cccgacaccg acgaccggca ccggatcgag gaaaagcgga agcggaccta cgagacattc 1860
aagagcatca tgaagaagtc ccccttcagc ggccccaccg atcccagacc cccccctaga 1920
agaatcgccg tgcccagcag atctagcgcc agcgtgccca agcctgcccc ccagccctac 1980
cctttcacca gcagcctgag caccatcaac tacgacgagt tccctaccat ggtgttcccc 2040
agcggccaga tctctcaggc ctctgctctg gcacctgctc cacctcaggt gctgcctcag 2100
gcccctgctc cagccccagc ccctgccatg gtgtctgcac tggcccaggc tccagctcct 2160
gtgcctgtgc tggcccctgg acctcctcag gctgtggccc ctcctgcccc taaacctacc 2220
caggccgggg agggaacact gtctgaggcc ctgctgcagc tccagttcga cgacgaggat 2280
ctgggagcac tgctgggcaa tagcaccgac cccgccgtgt ttaccgacct ggcctccgtg 2340
gacaacagcg agttccagca gctcctcaac cagggcatcc ctgtcgcccc acacaccacc 2400
gagcccatgc tgatggaata ccccgaggcc atcaccagac tggtcacagg cgcccagagg 2460
cctccagatc cagcaccagc tccactggga gcccctggcc tgcctaatgg gctgctgtct 2520
ggcgacgagg acttctccag cattgccgac atggacttca gcgccctgct gtcccagatc 2580
agcagc                                                            2586

<210> 13
<211> 2586
<212> DNA
<213> Unknown

<220> 
<223> variant of the wild type HEA3 transcription factor

<400> 13
atggtgtcca agctgtccca gctgcagaca gaactgctgg cagcactgct ggaaagcggc 60
ctgagcaaag aggccctgat tcaggcactc ggcgaacctg gaccttatct gctcgctggc 120
gaaggccctc tggataaggg cgagagctgt ggcggaggaa gaggagagct ggccgagctg 180
cctaacggcc tgggcgagac aagaggcagc gaggacgaga cagacgacga cggcgaggac 240
ttcacccccc ccatcctgaa agagctggaa aacctgagcc ccgaggaagc cgcccaccag 300
aaagccgtgg tggagacact gctgcaggaa gatccctggc gggtcgccaa gatggtcaag 360
agctacctgc agcagcacaa catcccccag cgggaggtgg tggacaccac cggcctgaac 420
cagagccacc tgagccagca cctgaacaag ggcaccccca tgaaaaccca gaagagagcc 480
gccctgtaca cttggtacgt gcggaagcag agagaggtgg cccagcagtt tacacacgcc 540
ggccagggcg gcctgatcga ggaacctacc ggcgacgagc tgcccaccaa gaagggcaga 600
cggaaccggt ttaagtgggg ccctgcatct cagcagatcc tgttccaggc ctacgagcgg 660
cagaagaacc ccagcaaaga ggaacgggag acactggtgg aagagtgcaa ccgggccgag 720
tgcatccaga gaggcgtgag cccttctcag gctcagggcc tcggcagcaa tctggtcacc 780
gaagtgcggg tgtacaattg gttcgccaac cggcggaaag aggaagcctt ccggcacaag 840
ctgtctgctg gcgatatgag agccgccaac ctgtggccca gccccctgat gatcaagcgg 900
agcaagaaga acagcctggc cctgagcctg accgccgatc agatggtgtc cgctctgctg 960
gacgccgagc cccctatcct gtacagcgag tacgacccca ccagaccctt cagcgaggcc 1020
agcatgatgg gcctgctgac caacctggcc gaccgggagc tggtgcacat gatcaactgg 1080
gccaagcggg tgcccggctt cgtggacctg accctgcacg accaggtcca cctgctggaa 1140
tgtgcctggc tggaaatcct gatgatcggc ctcgtgtgga gaagcatgga acaccccggc 1200
aagctgctgt tcgcccccaa cctgctcctg gaccggaacc agggaaagtg cgtggagggc 1260
atggtggaga tcttcgacat gctgctggcc acctccagcc ggttccggat gatgaacctg 1320
cagggcgagg aattcgtgtg cctgaagtcc atcatcctgc tgaacagcgg cgtgtacacc 1380
ttcctgtcat ccaccctgaa gtccctggaa gagaaggacc acatccaccg ggtgctggac 1440
aagatcaccg acaccctgat ccacctgatg gccaaggctg gcctgacact ccagcagcag 1500
caccagagac tggcccagct gctgctgatc ctgagccaca tccggcacat gagcaacaag 1560
cggatggaac acctgtacag catgaagtgc aagaacgtgg tgcccctgta cgacctgctg 1620
ctcgagatgc tggatgccca cagactgcac gcccctacaa gcagaggcgg agccagcgtg 1680
gaggaaaccg accagtctca cctggccacc gccggcagca caagcagcca cagcctgcag 1740
aagtactaca tcaccggcga ggccgaggga ttccctgcca ccgtggagtt ccagtacctg 1800
cccgacaccg acgaccggca ccggatcgag gaaaagcgga agcggaccta cgagacattc 1860
aagagcatca tgaagaagtc ccccttcagc ggccccaccg atcccagacc cccccctaga 1920
agaatcgccg tgcccagcag atctagcgcc agcgtgccca agcctgcccc ccagccctac 1980
cctttcacca gcagcctgag caccatcaac tacgacgagt tccctaccat ggtgttcccc 2040
agcggccaga tctctcaggc ctctgctctg gcacctgctc cacctcaggt gctgcctcag 2100
gcccctgctc cagccccagc ccctgccatg gtgtctgcac tggcccaggc tccagctcct 2160
gtgcctgtgc tggcccctgg acctcctcag gctgtggccc ctcctgcccc taaacctacc 2220
caggccgggg agggaacact gtctgaggcc ctgctgcagc tccagttcga cgacgaggat 2280
ctgggagcac tgctgggcaa tagcaccgac cccgccgtgt ttaccgacct ggcctccgtg 2340
gacaacagcg agttccagca gctcctcaac cagggcatcc ctgtcgcccc acacaccacc 2400
gagcccatgc tgatggaata ccccgaggcc atcaccagac tggtcacagg cgcccagagg 2460
cctccagatc cagcaccagc tccactggga gcccctggcc tgcctaatgg gctgctgtct 2520
ggcgacgagg acttcgagag cattgccgac atggacttca gcgccctgct gtcccagatc 2580
agcagc                                                            2586

<210> 14
<211> 2586
<212> DNA
<213> Unknown

<220> 
<223> variant of the wild type HEA3 transcription factor

<400> 14
atggtgtcca agctgtccca gctgcagaca gaactgctgg cagcactgct ggaaagcggc 60
ctgagcaaag aggccctgat tcaggcactc ggcgaacctg gaccttatct gctcgctggc 120
gaaggccctc tggataaggg cgagagctgt ggcggaggaa gaggagagct ggccgagctg 180
cctaacggcc tgggcgagac aagaggcagc gaggacgaga cagacgacga cggcgaggac 240
ttcacccccc ccatcctgaa agagctggaa aacctgagcc ccgaggaagc cgcccaccag 300
aaagccgtgg tggagacact gctgcaggaa gatccctggc gggtcgccaa gatggtcaag 360
agctacctgc agcagcacaa catcccccag cgggaggtgg tggacaccac cggcctgaac 420
cagagccacc tgagccagca cctgaacaag ggcaccccca tgaaaaccca gaagagagcc 480
gccctgtaca cttggtacgt gcggaagcag agagaggtgg cccagcagtt tacacacgcc 540
ggccagggcg gcctgatcga ggaacctacc ggcgacgagc tgcccaccaa gaagggcaga 600
cggaaccggt ttaagtgggg ccctgcatct cagcagatcc tgttccaggc ctacgagcgg 660
cagaagaacc ccagcaaaga ggaacgggag acactggtgg aagagtgcaa ccgggccgag 720
tgcatccaga gaggcgtgag cccttctcag gctcagggcc tcggcagcaa tctggtcacc 780
gaagtgcggg tgtacaattg gttcgccaac cggcggaaag aggaagcctt ccggcacaag 840
ctgtctgctg gcgatatgag agccgccaac ctgtggccca gccccctgat gatcaagcgg 900
agcaagaaga acagcctggc cctgagcctg accgccgatc agatggtgtc cgctctgctg 960
gacgccgagc cccctatcct gtacagcgag tacgacccca ccagaccctt cagcgaggcc 1020
agcatgatgg gcctgctgac caacctggcc gaccgggagc tggtgcacat gatcaactgg 1080
gccaagcggg tgcccggctt cgtggacctg accctgcacg accaggtcca cctgctggaa 1140
tgtgcctggc tggaaatcct gatgatcggc ctcgtgtgga gaagcatgga acaccccggc 1200
aagctgctgt tcgcccccaa cctgctcctg gaccggaacc agggaaagtg cgtggagggc 1260
atggtggaga tcttcgacat gctgctggcc acctccagcc ggttccggat gatgaacctg 1320
cagggcgagg aattcgtgtg cctgaagtcc atcatcctgc tgaacagcgg cgtgtacacc 1380
ttcctgtcat ccaccctgaa gtccctggaa gagaaggacc acatccaccg ggtgctggac 1440
aagatcaccg acaccctgat ccacctgatg gccaaggctg gcctgacact ccagcagcag 1500
caccagagac tggcccagct gctgctgatc ctgagccaca tccggcacat gagcaacaag 1560
cggatggaac acctgtacag catgaagtgc aagaacgtgg tgcccctgta cgacctgctg 1620
ctcgagatgc tggatgccca cagactgcac gcccctacaa gcagaggcgg agccagcgtg 1680
gaggaaaccg accagtctca cctggccacc gccggcagca caagcagcca cagcctgcag 1740
aagtactaca tcaccggcga ggccgaggga ttccctgcca ccgtggagtt ccagtacctg 1800
cccgacaccg acgaccggca ccggatcgag gaaaagcgga agcggaccta cgagacattc 1860
cagagcatca tgaagaagtc ccccttcagc ggccccaccg atcccagacc cccccctaga 1920
agaatcgccg tgcccagcag atctagcgcc agcgtgccca agcctgcccc ccagccctac 1980
cctttcacca gcagcctgag caccatcaac tacgacgagt tccctaccat ggtgttcccc 2040
agcggccaga tctctcaggc ctctgctctg gcacctgctc cacctcaggt gctgcctcag 2100
gcccctgctc cagccccagc ccctgccatg gtgtctgcac tggcccaggc tccagctcct 2160
gtgcctgtgc tggcccctgg acctcctcag gctgtggccc ctcctgcccc taaacctacc 2220
caggccgggg agggaacact gtctgaggcc ctgctgcagc tccagttcga cgacgaggat 2280
ctgggagcac tgctgggcaa tagcaccgac cccgccgtgt ttaccgacct ggcctccgtg 2340
gacaacagcg agttccagca gctcctcaac cagggcatcc ctgtcgcccc acacaccacc 2400
gagcccatgc tgatggaata ccccgaggcc atcaccagac tggtcacagg cgcccagagg 2460
cctccagatc cagcaccagc tccactggga gcccctggcc tgcctaatgg gctgctgtct 2520
ggcgacgagg acttctccag cattgccgac atggacttca gcgccctgct gtcccagatc 2580
agcagc                                                            2586

<210> 15
<211> 2586
<212> DNA
<213> Unknown

<220> 
<223> variant of the wild type HEA4 transcription factor

<400> 15
atggtgtcca agctgtccca gctgcagaca gaactgctgg cagcactgct ggaaagcggc 60
ctgagcaaag aggccctgat tcaggcactc ggcgaacctg gaccttatct gctcgctggc 120
gaaggccctc tggataaggg cgagagctgt ggcggaggaa gaggagagct ggccgagctg 180
cctaacggcc tgggcgagac aagaggcagc gaggacgaga cagacgacga cggcgaggac 240
ttcacccccc ccatcctgaa agagctggaa aacctgagcc ccgaggaagc cgcccaccag 300
aaagccgtgg tggagacact gctgcaggaa gatccctggc gggtcgccaa gatggtcaag 360
agctacctgc agcagcacaa catcccccag cgggaggtgg tggacaccac cggcctgaac 420
cagagccacc tgagccagca cctgaacaag ggcaccccca tgaaaaccca gaagagagcc 480
gccctgtaca cttggtacgt gcggaagcag agagaggtgg cccagcagtt tacacacgcc 540
ggccagggcg gcctgatcga ggaacctacc ggcgacgagc tgcccaccaa gaagggcaga 600
cggaaccggt ttaagtgggg ccctgcatct cagcagatcc tgttccaggc ctacgagcgg 660
cagaagaacc ccagcaaaga ggaacgggag acactggtgg aagagtgcaa ccgggccgag 720
tgcatccaga gaggcgtgag cccttctcag gctcagggcc tcggcagcaa tctggtcacc 780
gaagtgcggg tgtacaattg gttcgccaac cggcggaaag aggaagcctt ccggcacaag 840
ctgtctgctg gcgatatgag agccgccaac ctgtggccca gccccctgat gatcaagcgg 900
agcaagaaga acagcctggc cctgagcctg accgccgatc agatggtgtc cgctctgctg 960
gacgccgagc cccctatcct gtacagcgag tacgacccca ccagaccctt cagcgaggcc 1020
agcatgatgg gcctgctgac caacctggcc gaccgggagc tggtgcacat gatcaactgg 1080
gccaagcggg tgcccggctt cgtggacctg accctgcacg accaggtcca cctgctggaa 1140
tgtgcctggc tggaaatcct gatgatcggc ctcgtgtgga gaagcatgga acaccccgtg 1200
aagctgctgt tcgcccccaa cctgctcctg gaccggaacc agggaaagtg cgtggagggc 1260
atggtggaga tcttcgacat gctgctggcc acctccagcc ggttccggat gatgaacctg 1320
cagggcgagg aattcgtgtg cctgaagtcc atcatcctgc tgaacagcgg cgtgtacacc 1380
ttcctgtcat ccaccctgaa gtccctggaa gagaaggacc acatccaccg ggtgctggac 1440
aagatcaccg acaccctgat ccacctgatg gccaaggctg gcctgacact ccagcagcag 1500
caccagagac tggcccagct gctgctgatc ctgagccaca tccggcacat gagcaacaag 1560
ggaatggaac acctgtacag catgaagtgc aagaacgtgg tgcccctgta cgacctgctg 1620
ctcgaggctg ccgatgccca cagactgcac gcccctacaa gcagaggcgg agccagcgtg 1680
gaggaaaccg accagtctca cctggccacc gccggcagca caagcagcca cagcctgcag 1740
aagtactaca tcaccggcga ggccgaggga ttccctgcca ccgtggagtt ccagtacctg 1800
cccgacaccg acgaccggca ccggatcgag gaaaagcgga agcggaccta cgagacattc 1860
aagagcatca tgaagaagtc ccccttcagc ggccccaccg atcccagacc cccccctaga 1920
agaatcgccg tgcccagcag atctagcgcc agcgtgccca agcctgcccc ccagccctac 1980
cctttcacca gcagcctgag caccatcaac tacgacgagt tccctaccat ggtgttcccc 2040
agcggccaga tctctcaggc ctctgctctg gcacctgctc cacctcaggt gctgcctcag 2100
gcccctgctc cagccccagc ccctgccatg gtgtctgcac tggcccaggc tccagctcct 2160
gtgcctgtgc tggcccctgg acctcctcag gctgtggccc ctcctgcccc taaacctacc 2220
caggccgggg agggaacact gtctgaggcc ctgctgcagc tccagttcga cgacgaggat 2280
ctgggagcac tgctgggcaa tagcaccgac cccgccgtgt ttaccgacct ggcctccgtg 2340
gacaacagcg agttccagca gctcctcaac cagggcatcc ctgtcgcccc acacaccacc 2400
gagcccatgc tgatggaata ccccgaggcc atcaccagac tggtcacagg cgcccagagg 2460
cctccagatc cagcaccagc tccactggga gcccctggcc tgcctaatgg gctgctgtct 2520
ggcgacgagg acttctccag cattgccgac atggacttca gcgccctgct gtcccagatc 2580
agcagc                                                            2586

<210> 16
<211> 2586
<212> DNA
<213> Unknown

<220> 
<223> variant of the wild type HEA4 transcription factor

<400> 16
atggtgtcca agctgtccca gctgcagaca gaactgctgg cagcactgct ggaaagcggc 60
ctgagcaaag aggccctgat tcaggcactc ggcgaacctg gaccttatct gctcgctggc 120
gaaggccctc tggataaggg cgagagctgt ggcggaggaa gaggagagct ggccgagctg 180
cctaacggcc tgggcgagac aagaggcagc gaggacgaga cagacgacga cggcgaggac 240
ttcacccccc ccatcctgaa agagctggaa aacctgagcc ccgaggaagc cgcccaccag 300
aaagccgtgg tggagacact gctgcaggaa gatccctggc gggtcgccaa gatggtcaag 360
agctacctgc agcagcacaa catcccccag cgggaggtgg tggacaccac cggcctgaac 420
cagagccacc tgagccagca cctgaacaag ggcaccccca tgaaaaccca gaagagagcc 480
gccctgtaca cttggtacgt gcggaagcag agagaggtgg cccagcagtt tacacacgcc 540
ggccagggcg gcctgatcga ggaacctacc ggcgacgagc tgcccaccaa gaagggcaga 600
cggaaccggt ttaagtgggg ccctgcatct cagcagatcc tgttccaggc ctacgagcgg 660
cagaagaacc ccagcaaaga ggaacgggag acactggtgg aagagtgcaa ccgggccgag 720
tgcatccaga gaggcgtgag cccttctcag gctcagggcc tcggcagcaa tctggtcacc 780
gaagtgcggg tgtacaattg gttcgccaac cggcggaaag aggaagcctt ccggcacaag 840
ctgtctgctg gcgatatgag agccgccaac ctgtggccca gccccctgat gatcaagcgg 900
agcaagaaga acagcctggc cctgagcctg accgccgatc agatggtgtc cgctctgctg 960
gacgccgagc cccctatcct gtacagcgag tacgacccca ccagaccctt cagcgaggcc 1020
agcatgatgg gcctgctgac caacctggcc gaccgggagc tggtgcacat gatcaactgg 1080
gccaagcggg tgcccggctt cgtggacctg accctgcacg accaggtcca cctgctggaa 1140
tgtgcctggc tggaaatcct gatgatcggc ctcgtgtgga gaagcatgga acaccccgtg 1200
aagctgctgt tcgcccccaa cctgctcctg gaccggaacc agggaaagtg cgtggagggc 1260
atggtggaga tcttcgacat gctgctggcc acctccagcc ggttccggat gatgaacctg 1320
cagggcgagg aattcgtgtg cctgaagtcc atcatcctgc tgaacagcgg cgtgtacacc 1380
ttcctgtcat ccaccctgaa gtccctggaa gagaaggacc acatccaccg ggtgctggac 1440
aagatcaccg acaccctgat ccacctgatg gccaaggctg gcctgacact ccagcagcag 1500
caccagagac tggcccagct gctgctgatc ctgagccaca tccggcacat gagcaacaag 1560
ggaatggaac acctgtacag catgaagtgc aagaacgtgg tgcccctgta cgacctgctg 1620
ctcgaggctg ccgatgccca cagactgcac gcccctacaa gcagaggcgg agccagcgtg 1680
gaggaaaccg accagtctca cctggccacc gccggcagca caagcagcca cagcctgcag 1740
aagtactaca tcaccggcga ggccgaggga ttccctgcca ccgtggagtt ccagtacctg 1800
cccgacaccg acgaccggca ccggatcgag gaaaagcgga agcggaccta cgagacattc 1860
aagagcatca tgaagaagtc ccccttcagc ggccccaccg atcccagacc cccccctaga 1920
agaatcgccg tgcccagcag atctagcgcc agcgtgccca agcctgcccc ccagccctac 1980
cctttcacca gcagcctgag caccatcaac tacgacgagt tccctaccat ggtgttcccc 2040
agcggccaga tctctcaggc ctctgctctg gcacctgctc cacctcaggt gctgcctcag 2100
gcccctgctc cagccccagc ccctgccatg gtgtctgcac tggcccaggc tccagctcct 2160
gtgcctgtgc tggcccctgg acctcctcag gctgtggccc ctcctgcccc taaacctacc 2220
caggccgggg agggaacact gtctgaggcc ctgctgcagc tccagttcga cgacgaggat 2280
ctgggagcac tgctgggcaa tagcaccgac cccgccgtgt ttaccgacct ggcctccgtg 2340
gacaacagcg agttccagca gctcctcaac cagggcatcc ctgtcgcccc acacaccacc 2400
gagcccatgc tgatggaata ccccgaggcc atcaccagac tggtcacagg cgcccagagg 2460
cctccagatc cagcaccagc tccactggga gcccctggcc tgcctaatgg gctgctgtct 2520
ggcgacgagg acttcgagag cattgccgac atggacttca gcgccctgct gtcccagatc 2580
agcagc                                                            2586

<210> 17
<211> 2586
<212> DNA
<213> Unknown

<220> 
<223> variant of the wild type HEA4 transcription factor

<400> 17
atggtgtcca agctgtccca gctgcagaca gaactgctgg cagcactgct ggaaagcggc 60
ctgagcaaag aggccctgat tcaggcactc ggcgaacctg gaccttatct gctcgctggc 120
gaaggccctc tggataaggg cgagagctgt ggcggaggaa gaggagagct ggccgagctg 180
cctaacggcc tgggcgagac aagaggcagc gaggacgaga cagacgacga cggcgaggac 240
ttcacccccc ccatcctgaa agagctggaa aacctgagcc ccgaggaagc cgcccaccag 300
aaagccgtgg tggagacact gctgcaggaa gatccctggc gggtcgccaa gatggtcaag 360
agctacctgc agcagcacaa catcccccag cgggaggtgg tggacaccac cggcctgaac 420
cagagccacc tgagccagca cctgaacaag ggcaccccca tgaaaaccca gaagagagcc 480
gccctgtaca cttggtacgt gcggaagcag agagaggtgg cccagcagtt tacacacgcc 540
ggccagggcg gcctgatcga ggaacctacc ggcgacgagc tgcccaccaa gaagggcaga 600
cggaaccggt ttaagtgggg ccctgcatct cagcagatcc tgttccaggc ctacgagcgg 660
cagaagaacc ccagcaaaga ggaacgggag acactggtgg aagagtgcaa ccgggccgag 720
tgcatccaga gaggcgtgag cccttctcag gctcagggcc tcggcagcaa tctggtcacc 780
gaagtgcggg tgtacaattg gttcgccaac cggcggaaag aggaagcctt ccggcacaag 840
ctgtctgctg gcgatatgag agccgccaac ctgtggccca gccccctgat gatcaagcgg 900
agcaagaaga acagcctggc cctgagcctg accgccgatc agatggtgtc cgctctgctg 960
gacgccgagc cccctatcct gtacagcgag tacgacccca ccagaccctt cagcgaggcc 1020
agcatgatgg gcctgctgac caacctggcc gaccgggagc tggtgcacat gatcaactgg 1080
gccaagcggg tgcccggctt cgtggacctg accctgcacg accaggtcca cctgctggaa 1140
tgtgcctggc tggaaatcct gatgatcggc ctcgtgtgga gaagcatgga acaccccgtg 1200
aagctgctgt tcgcccccaa cctgctcctg gaccggaacc agggaaagtg cgtggagggc 1260
atggtggaga tcttcgacat gctgctggcc acctccagcc ggttccggat gatgaacctg 1320
cagggcgagg aattcgtgtg cctgaagtcc atcatcctgc tgaacagcgg cgtgtacacc 1380
ttcctgtcat ccaccctgaa gtccctggaa gagaaggacc acatccaccg ggtgctggac 1440
aagatcaccg acaccctgat ccacctgatg gccaaggctg gcctgacact ccagcagcag 1500
caccagagac tggcccagct gctgctgatc ctgagccaca tccggcacat gagcaacaag 1560
ggaatggaac acctgtacag catgaagtgc aagaacgtgg tgcccctgta cgacctgctg 1620
ctcgaggctg ccgatgccca cagactgcac gcccctacaa gcagaggcgg agccagcgtg 1680
gaggaaaccg accagtctca cctggccacc gccggcagca caagcagcca cagcctgcag 1740
aagtactaca tcaccggcga ggccgaggga ttccctgcca ccgtggagtt ccagtacctg 1800
cccgacaccg acgaccggca ccggatcgag gaaaagcgga agcggaccta cgagacattc 1860
cagagcatca tgaagaagtc ccccttcagc ggccccaccg atcccagacc cccccctaga 1920
agaatcgccg tgcccagcag atctagcgcc agcgtgccca agcctgcccc ccagccctac 1980
cctttcacca gcagcctgag caccatcaac tacgacgagt tccctaccat ggtgttcccc 2040
agcggccaga tctctcaggc ctctgctctg gcacctgctc cacctcaggt gctgcctcag 2100
gcccctgctc cagccccagc ccctgccatg gtgtctgcac tggcccaggc tccagctcct 2160
gtgcctgtgc tggcccctgg acctcctcag gctgtggccc ctcctgcccc taaacctacc 2220
caggccgggg agggaacact gtctgaggcc ctgctgcagc tccagttcga cgacgaggat 2280
ctgggagcac tgctgggcaa tagcaccgac cccgccgtgt ttaccgacct ggcctccgtg 2340
gacaacagcg agttccagca gctcctcaac cagggcatcc ctgtcgcccc acacaccacc 2400
gagcccatgc tgatggaata ccccgaggcc atcaccagac tggtcacagg cgcccagagg 2460
cctccagatc cagcaccagc tccactggga gcccctggcc tgcctaatgg gctgctgtct 2520
ggcgacgagg acttctccag cattgccgac atggacttca gcgccctgct gtcccagatc 2580
agcagc                                                            2586

<210> 18
<211> 2586
<212> DNA
<213> Unknown

<220> 
<223> variant of the wild type HEA4 transcription factor

<400> 18
atggtgtcca agctgtccca gctgcagaca gaactgctgg cagcactgct ggaaagcggc 60
ctgagcaaag aggccctgat tcaggcactc ggcgaacctg gaccttatct gctcgctggc 120
gaaggccctc tggataaggg cgagagctgt ggcggaggaa gaggagagct ggccgagctg 180
cctaacggcc tgggcgagac aagaggcagc gaggacgaga cagacgacga cggcgaggac 240
ttcacccccc ccatcctgaa agagctggaa aacctgagcc ccgaggaagc cgcccaccag 300
aaagccgtgg tggagacact gctgcaggaa gatccctggc gggtcgccaa gatggtcaag 360
agctacctgc agcagcacaa catcccccag cgggaggtgg tggacaccac cggcctgaac 420
cagagccacc tgagccagca cctgaacaag ggcaccccca tgaaaaccca gaagagagcc 480
gccctgtaca cttggtacgt gcggaagcag agagaggtgg cccagcagtt tacacacgcc 540
ggccagggcg gcctgatcga ggaacctacc ggcgacgagc tgcccaccaa gaagggcaga 600
cggaaccggt ttaagtgggg ccctgcatct cagcagatcc tgttccaggc ctacgagcgg 660
cagaagaacc ccagcaaaga ggaacgggag acactggtgg aagagtgcaa ccgggccgag 720
tgcatccaga gaggcgtgag cccttctcag gctcagggcc tcggcagcaa tctggtcacc 780
gaagtgcggg tgtacaattg gttcgccaac cggcggaaag aggaagcctt ccggcacaag 840
ctgtctgctg gcgatatgag agccgccaac ctgtggccca gccccctgat gatcaagcgg 900
agcaagaaga acagcctggc cctgagcctg accgccgatc agatggtgtc cgctctgctg 960
gacgccgagc cccctatcct gtacagcgag tacgacccca ccagaccctt cagcgaggcc 1020
agcatgatgg gcctgctgac caacctggcc gaccgggagc tggtgcacat gatcaactgg 1080
gccaagcggg tgcccggctt cgtggacctg accctgcacg accaggtcca cctgctggaa 1140
tgtgcctggc tggaaatcct gatgatcggc ctcgtgtgga gaagcatgga acaccccgtg 1200
aagctgctgt tcgcccccaa cctgctcctg gaccggaacc agggaaagtg cgtggagggc 1260
atggtggaga tcttcgacat gctgctggcc acctccagcc ggttccggat gatgaacctg 1320
cagggcgagg aattcgtgtg cctgaagtcc atcatcctgc tgaacagcgg cgtgtacacc 1380
ttcctgtcat ccaccctgaa gtccctggaa gagaaggacc acatccaccg ggtgctggac 1440
aagatcaccg acaccctgat ccacctgatg gccaaggctg gcctgacact ccagcagcag 1500
caccagagac tggcccagct gctgctgatc ctgagccaca tccggcacat gagcaacaag 1560
ggaatggaac acctgtacag catgaagtgc aagaacgtgg tgcccctgta cgacctgctg 1620
ctcgaggctg ccgatgccca cagactgcac gcccctacaa gcagaggcgg agccagcgtg 1680
gaggaaaccg accagtctca cctggccacc gccggcagca caagcagcca cagcctgcag 1740
aagtactaca tcaccggcga ggccgaggga ttccctgcca ccgtggagtt ccagtacctg 1800
cccgacaccg acgaccggca ccggatcgag gaaaagcgga agcggaccta cgagacattc 1860
cagagcatca tgaagaagtc ccccttcagc ggccccaccg atcccagacc cccccctaga 1920
agaatcgccg tgcccagcag atctagcgcc agcgtgccca agcctgcccc ccagccctac 1980
cctttcacca gcagcctgag caccatcaac tacgacgagt tccctaccat ggtgttcccc 2040
agcggccaga tctctcaggc ctctgctctg gcacctgctc cacctcaggt gctgcctcag 2100
gcccctgctc cagccccagc ccctgccatg gtgtctgcac tggcccaggc tccagctcct 2160
gtgcctgtgc tggcccctgg acctcctcag gctgtggccc ctcctgcccc taaacctacc 2220
caggccgggg agggaacact gtctgaggcc ctgctgcagc tccagttcga cgacgaggat 2280
ctgggagcac tgctgggcaa tagcaccgac cccgccgtgt ttaccgacct ggcctccgtg 2340
gacaacagcg agttccagca gctcctcaac cagggcatcc ctgtcgcccc acacaccacc 2400
gagcccatgc tgatggaata ccccgaggcc atcaccagac tggtcacagg cgcccagagg 2460
cctccagatc cagcaccagc tccactggga gcccctggcc tgcctaatgg gctgctgtct 2520
ggcgacgagg acttcgagag cattgccgac atggacttca gcgccctgct gtcccagatc 2580
agcagc                                                            2586

<210> 19
<211> 2586
<212> DNA
<213> Unknown

<220> 
<223> variant of the wild type HEA3 transcription factor

<400> 19
atggtgtcca agctgtccca gctgcagaca gaactgctgg cagcactgct ggaaagcggc 60
ctgagcaaag aggccctgat tcaggcactc ggcgaacctg gaccttatct gctcgctggc 120
gaaggccctc tggataaggg cgagagctgt ggcggaggaa gaggagagct ggccgagctg 180
cctaacggcc tgggcgagac aagaggcagc gaggacgaga cagacgacga cggcgaggac 240
ttcacccccc ccatcctgaa agagctggaa aacctgagcc ccgaggaagc cgcccaccag 300
aaagccgtgg tggagacact gctgcaggaa gatccctggc gggtcgccaa gatggtcaag 360
agctacctgc agcagcacaa catcccccag cgggaggtgg tggacaccac cggcctgaac 420
cagagccacc tgagccagca cctgaacaag ggcaccccca tgaaaaccca gaagagagcc 480
gccctgtaca cttggtacgt gcggaagcag agagaggtgg cccagcagtt tacacacgcc 540
ggccagggcg gcctgatcga ggaacctacc ggcgacgagc tgcccaccaa gaagggcaga 600
cggaaccggt ttaagtgggg ccctgcatct cagcagatcc tgttccaggc ctacgagcgg 660
cagaagaacc ccagcaaaga ggaacgggag acactggtgg aagagtgcaa ccgggccgag 720
tgcatccaga gaggcgtgag cccttctcag gctcagggcc tcggcagcaa tctggtcacc 780
gaagtgcggg tgtacaattg gttcgccaac cggcggaaag aggaagcctt ccggcacaag 840
ctgtctgctg gcgatatgag agccgccaac ctgtggccca gccccctgat gatcaagcgg 900
agcaagaaga acagcctggc cctgagcctg accgccgatc agatggtgtc cgctctgctg 960
gacgccgagc cccctatcct gtacagcgag tacgacccca ccagaccctt cagcgaggcc 1020
agcatgatgg gcctgctgac caacctggcc gaccgggagc tggtgcacat gatcaactgg 1080
gccaagcggg tgcccggctt cgtggacctg accctgcacg accaggtcca cctgctggaa 1140
tgtgcctgga tggaaatcct gatgatcggc ctcgtgtgga gaagcatgga acaccccggc 1200
aagctgctgt tcgcccccaa cctgctcctg gaccggaacc agggaaagtg cgtggagggc 1260
ggcgtggaga tcttcgacat gctgctggcc acctccagcc ggttccggat gatgaacctg 1320
cagggcgagg aattcgtgtg cctgaagtcc atcatcctgc tgaacagcgg cgtgtacacc 1380
ttcctgtcat ccaccctgaa gtccctggaa gagaaggacc acatccaccg ggtgctggac 1440
aagatcaccg acaccctgat ccacctgatg gccaaggctg gcctgacact ccagcagcag 1500
caccagagac tggcccagct gctgctgatc ctgagccaca tccggcacat gagcaacaag 1560
cggatggaac acctgtacag catgaagtgc aagaacgtgg tgcccctgta cgacctgctg 1620
ctcgagatgc tggatgccca cagactgcac gcccctacaa gcagaggcgg agccagcgtg 1680
gaggaaaccg accagtctca cctggccacc gccggcagca caagcagcca cagcctgcag 1740
aagtactaca tcaccggcga ggccgaggga ttccctgcca ccgtggagtt ccagtacctg 1800
cccgacaccg acgaccggca ccggatcgag gaaaagcgga agcggaccta cgagacattc 1860
aagagcatca tgaagaagtc ccccttcagc ggccccaccg atcccagacc cccccctaga 1920
agaatcgccg tgcccagcag atctagcgcc agcgtgccca agcctgcccc ccagccctac 1980
cctttcacca gcagcctgag caccatcaac tacgacgagt tccctaccat ggtgttcccc 2040
agcggccaga tctctcaggc ctctgctctg gcacctgctc cacctcaggt gctgcctcag 2100
gcccctgctc cagccccagc ccctgccatg gtgtctgcac tggcccaggc tccagctcct 2160
gtgcctgtgc tggcccctgg acctcctcag gctgtggccc ctcctgcccc taaacctacc 2220
caggccgggg agggaacact gtctgaggcc ctgctgcagc tccagttcga cgacgaggat 2280
ctgggagcac tgctgggcaa tagcaccgac cccgccgtgt ttaccgacct ggcctccgtg 2340
gacaacagcg agttccagca gctcctcaac cagggcatcc ctgtcgcccc acacaccacc 2400
gagcccatgc tgatggaata ccccgaggcc atcaccagac tggtcacagg cgcccagagg 2460
cctccagatc cagcaccagc tccactggga gcccctggcc tgcctaatgg gctgctgtct 2520
ggcgacgagg acttctccag cattgccgac atggacttca gcgccctgct gtcccagatc 2580
agcagc                                                            2586

<210> 20
<211> 2586
<212> DNA
<213> Unknown

<220> 
<223> variant of the wild type HEA3 transcription factor

<400> 20
atggtgtcca agctgtccca gctgcagaca gaactgctgg cagcactgct ggaaagcggc 60
ctgagcaaag aggccctgat tcaggcactc ggcgaacctg gaccttatct gctcgctggc 120
gaaggccctc tggataaggg cgagagctgt ggcggaggaa gaggagagct ggccgagctg 180
cctaacggcc tgggcgagac aagaggcagc gaggacgaga cagacgacga cggcgaggac 240
ttcacccccc ccatcctgaa agagctggaa aacctgagcc ccgaggaagc cgcccaccag 300
aaagccgtgg tggagacact gctgcaggaa gatccctggc gggtcgccaa gatggtcaag 360
agctacctgc agcagcacaa catcccccag cgggaggtgg tggacaccac cggcctgaac 420
cagagccacc tgagccagca cctgaacaag ggcaccccca tgaaaaccca gaagagagcc 480
gccctgtaca cttggtacgt gcggaagcag agagaggtgg cccagcagtt tacacacgcc 540
ggccagggcg gcctgatcga ggaacctacc ggcgacgagc tgcccaccaa gaagggcaga 600
cggaaccggt ttaagtgggg ccctgcatct cagcagatcc tgttccaggc ctacgagcgg 660
cagaagaacc ccagcaaaga ggaacgggag acactggtgg aagagtgcaa ccgggccgag 720
tgcatccaga gaggcgtgag cccttctcag gctcagggcc tcggcagcaa tctggtcacc 780
gaagtgcggg tgtacaattg gttcgccaac cggcggaaag aggaagcctt ccggcacaag 840
ctgtctgctg gcgatatgag agccgccaac ctgtggccca gccccctgat gatcaagcgg 900
agcaagaaga acagcctggc cctgagcctg accgccgatc agatggtgtc cgctctgctg 960
gacgccgagc cccctatcct gtacagcgag tacgacccca ccagaccctt cagcgaggcc 1020
agcatgatgg gcctgctgac caacctggcc gaccgggagc tggtgcacat gatcaactgg 1080
gccaagcggg tgcccggctt cgtggacctg accctgcacg accaggtcca cctgctggaa 1140
tgtgcctgga tggaaatcct gatgatcggc ctcgtgtgga gaagcatgga acaccccggc 1200
aagctgctgt tcgcccccaa cctgctcctg gaccggaacc agggaaagtg cgtggagggc 1260
ggcgtggaga tcttcgacat gctgctggcc acctccagcc ggttccggat gatgaacctg 1320
cagggcgagg aattcgtgtg cctgaagtcc atcatcctgc tgaacagcgg cgtgtacacc 1380
ttcctgtcat ccaccctgaa gtccctggaa gagaaggacc acatccaccg ggtgctggac 1440
aagatcaccg acaccctgat ccacctgatg gccaaggctg gcctgacact ccagcagcag 1500
caccagagac tggcccagct gctgctgatc ctgagccaca tccggcacat gagcaacaag 1560
cggatggaac acctgtacag catgaagtgc aagaacgtgg tgcccctgta cgacctgctg 1620
ctcgagatgc tggatgccca cagactgcac gcccctacaa gcagaggcgg agccagcgtg 1680
gaggaaaccg accagtctca cctggccacc gccggcagca caagcagcca cagcctgcag 1740
aagtactaca tcaccggcga ggccgaggga ttccctgcca ccgtggagtt ccagtacctg 1800
cccgacaccg acgaccggca ccggatcgag gaaaagcgga agcggaccta cgagacattc 1860
aagagcatca tgaagaagtc ccccttcagc ggccccaccg atcccagacc cccccctaga 1920
agaatcgccg tgcccagcag atctagcgcc agcgtgccca agcctgcccc ccagccctac 1980
cctttcacca gcagcctgag caccatcaac tacgacgagt tccctaccat ggtgttcccc 2040
agcggccaga tctctcaggc ctctgctctg gcacctgctc cacctcaggt gctgcctcag 2100
gcccctgctc cagccccagc ccctgccatg gtgtctgcac tggcccaggc tccagctcct 2160
gtgcctgtgc tggcccctgg acctcctcag gctgtggccc ctcctgcccc taaacctacc 2220
caggccgggg agggaacact gtctgaggcc ctgctgcagc tccagttcga cgacgaggat 2280
ctgggagcac tgctgggcaa tagcaccgac cccgccgtgt ttaccgacct ggcctccgtg 2340
gacaacagcg agttccagca gctcctcaac cagggcatcc ctgtcgcccc acacaccacc 2400
gagcccatgc tgatggaata ccccgaggcc atcaccagac tggtcacagg cgcccagagg 2460
cctccagatc cagcaccagc tccactggga gcccctggcc tgcctaatgg gctgctgtct 2520
ggcgacgagg acttcgagag cattgccgac atggacttca gcgccctgct gtcccagatc 2580
agcagc                                                            2586

<210> 21
<211> 2586
<212> DNA
<213> Unknown

<220> 
<223> variant of the wild type HEA3 transcription factor

<400> 21
atggtgtcca agctgtccca gctgcagaca gaactgctgg cagcactgct ggaaagcggc 60
ctgagcaaag aggccctgat tcaggcactc ggcgaacctg gaccttatct gctcgctggc 120
gaaggccctc tggataaggg cgagagctgt ggcggaggaa gaggagagct ggccgagctg 180
cctaacggcc tgggcgagac aagaggcagc gaggacgaga cagacgacga cggcgaggac 240
ttcacccccc ccatcctgaa agagctggaa aacctgagcc ccgaggaagc cgcccaccag 300
aaagccgtgg tggagacact gctgcaggaa gatccctggc gggtcgccaa gatggtcaag 360
agctacctgc agcagcacaa catcccccag cgggaggtgg tggacaccac cggcctgaac 420
cagagccacc tgagccagca cctgaacaag ggcaccccca tgaaaaccca gaagagagcc 480
gccctgtaca cttggtacgt gcggaagcag agagaggtgg cccagcagtt tacacacgcc 540
ggccagggcg gcctgatcga ggaacctacc ggcgacgagc tgcccaccaa gaagggcaga 600
cggaaccggt ttaagtgggg ccctgcatct cagcagatcc tgttccaggc ctacgagcgg 660
cagaagaacc ccagcaaaga ggaacgggag acactggtgg aagagtgcaa ccgggccgag 720
tgcatccaga gaggcgtgag cccttctcag gctcagggcc tcggcagcaa tctggtcacc 780
gaagtgcggg tgtacaattg gttcgccaac cggcggaaag aggaagcctt ccggcacaag 840
ctgtctgctg gcgatatgag agccgccaac ctgtggccca gccccctgat gatcaagcgg 900
agcaagaaga acagcctggc cctgagcctg accgccgatc agatggtgtc cgctctgctg 960
gacgccgagc cccctatcct gtacagcgag tacgacccca ccagaccctt cagcgaggcc 1020
agcatgatgg gcctgctgac caacctggcc gaccgggagc tggtgcacat gatcaactgg 1080
gccaagcggg tgcccggctt cgtggacctg accctgcacg accaggtcca cctgctggaa 1140
tgtgcctgga tggaaatcct gatgatcggc ctcgtgtgga gaagcatgga acaccccggc 1200
aagctgctgt tcgcccccaa cctgctcctg gaccggaacc agggaaagtg cgtggagggc 1260
ggcgtggaga tcttcgacat gctgctggcc acctccagcc ggttccggat gatgaacctg 1320
cagggcgagg aattcgtgtg cctgaagtcc atcatcctgc tgaacagcgg cgtgtacacc 1380
ttcctgtcat ccaccctgaa gtccctggaa gagaaggacc acatccaccg ggtgctggac 1440
aagatcaccg acaccctgat ccacctgatg gccaaggctg gcctgacact ccagcagcag 1500
caccagagac tggcccagct gctgctgatc ctgagccaca tccggcacat gagcaacaag 1560
cggatggaac acctgtacag catgaagtgc aagaacgtgg tgcccctgta cgacctgctg 1620
ctcgagatgc tggatgccca cagactgcac gcccctacaa gcagaggcgg agccagcgtg 1680
gaggaaaccg accagtctca cctggccacc gccggcagca caagcagcca cagcctgcag 1740
aagtactaca tcaccggcga ggccgaggga ttccctgcca ccgtggagtt ccagtacctg 1800
cccgacaccg acgaccggca ccggatcgag gaaaagcgga agcggaccta cgagacattc 1860
cagagcatca tgaagaagtc ccccttcagc ggccccaccg atcccagacc cccccctaga 1920
agaatcgccg tgcccagcag atctagcgcc agcgtgccca agcctgcccc ccagccctac 1980
cctttcacca gcagcctgag caccatcaac tacgacgagt tccctaccat ggtgttcccc 2040
agcggccaga tctctcaggc ctctgctctg gcacctgctc cacctcaggt gctgcctcag 2100
gcccctgctc cagccccagc ccctgccatg gtgtctgcac tggcccaggc tccagctcct 2160
gtgcctgtgc tggcccctgg acctcctcag gctgtggccc ctcctgcccc taaacctacc 2220
caggccgggg agggaacact gtctgaggcc ctgctgcagc tccagttcga cgacgaggat 2280
ctgggagcac tgctgggcaa tagcaccgac cccgccgtgt ttaccgacct ggcctccgtg 2340
gacaacagcg agttccagca gctcctcaac cagggcatcc ctgtcgcccc acacaccacc 2400
gagcccatgc tgatggaata ccccgaggcc atcaccagac tggtcacagg cgcccagagg 2460
cctccagatc cagcaccagc tccactggga gcccctggcc tgcctaatgg gctgctgtct 2520
ggcgacgagg acttctccag cattgccgac atggacttca gcgccctgct gtcccagatc 2580
agcagc                                                            2586

<210> 22
<211> 2586
<212> DNA
<213> Unknown

<220> 
<223> variant of the wild type HEA3 transcription factor

<400> 22
atggtgtcca agctgtccca gctgcagaca gaactgctgg cagcactgct ggaaagcggc 60
ctgagcaaag aggccctgat tcaggcactc ggcgaacctg gaccttatct gctcgctggc 120
gaaggccctc tggataaggg cgagagctgt ggcggaggaa gaggagagct ggccgagctg 180
cctaacggcc tgggcgagac aagaggcagc gaggacgaga cagacgacga cggcgaggac 240
ttcacccccc ccatcctgaa agagctggaa aacctgagcc ccgaggaagc cgcccaccag 300
aaagccgtgg tggagacact gctgcaggaa gatccctggc gggtcgccaa gatggtcaag 360
agctacctgc agcagcacaa catcccccag cgggaggtgg tggacaccac cggcctgaac 420
cagagccacc tgagccagca cctgaacaag ggcaccccca tgaaaaccca gaagagagcc 480
gccctgtaca cttggtacgt gcggaagcag agagaggtgg cccagcagtt tacacacgcc 540
ggccagggcg gcctgatcga ggaacctacc ggcgacgagc tgcccaccaa gaagggcaga 600
cggaaccggt ttaagtgggg ccctgcatct cagcagatcc tgttccaggc ctacgagcgg 660
cagaagaacc ccagcaaaga ggaacgggag acactggtgg aagagtgcaa ccgggccgag 720
tgcatccaga gaggcgtgag cccttctcag gctcagggcc tcggcagcaa tctggtcacc 780
gaagtgcggg tgtacaattg gttcgccaac cggcggaaag aggaagcctt ccggcacaag 840
ctgtctgctg gcgatatgag agccgccaac ctgtggccca gccccctgat gatcaagcgg 900
agcaagaaga acagcctggc cctgagcctg accgccgatc agatggtgtc cgctctgctg 960
gacgccgagc cccctatcct gtacagcgag tacgacccca ccagaccctt cagcgaggcc 1020
agcatgatgg gcctgctgac caacctggcc gaccgggagc tggtgcacat gatcaactgg 1080
gccaagcggg tgcccggctt cgtggacctg accctgcacg accaggtcca cctgctggaa 1140
tgtgcctgga tggaaatcct gatgatcggc ctcgtgtgga gaagcatgga acaccccggc 1200
aagctgctgt tcgcccccaa cctgctcctg gaccggaacc agggaaagtg cgtggagggc 1260
ggcgtggaga tcttcgacat gctgctggcc acctccagcc ggttccggat gatgaacctg 1320
cagggcgagg aattcgtgtg cctgaagtcc atcatcctgc tgaacagcgg cgtgtacacc 1380
ttcctgtcat ccaccctgaa gtccctggaa gagaaggacc acatccaccg ggtgctggac 1440
aagatcaccg acaccctgat ccacctgatg gccaaggctg gcctgacact ccagcagcag 1500
caccagagac tggcccagct gctgctgatc ctgagccaca tccggcacat gagcaacaag 1560
cggatggaac acctgtacag catgaagtgc aagaacgtgg tgcccctgta cgacctgctg 1620
ctcgagatgc tggatgccca cagactgcac gcccctacaa gcagaggcgg agccagcgtg 1680
gaggaaaccg accagtctca cctggccacc gccggcagca caagcagcca cagcctgcag 1740
aagtactaca tcaccggcga ggccgaggga ttccctgcca ccgtggagtt ccagtacctg 1800
cccgacaccg acgaccggca ccggatcgag gaaaagcgga agcggaccta cgagacattc 1860
cagagcatca tgaagaagtc ccccttcagc ggccccaccg atcccagacc cccccctaga 1920
agaatcgccg tgcccagcag atctagcgcc agcgtgccca agcctgcccc ccagccctac 1980
cctttcacca gcagcctgag caccatcaac tacgacgagt tccctaccat ggtgttcccc 2040
agcggccaga tctctcaggc ctctgctctg gcacctgctc cacctcaggt gctgcctcag 2100
gcccctgctc cagccccagc ccctgccatg gtgtctgcac tggcccaggc tccagctcct 2160
gtgcctgtgc tggcccctgg acctcctcag gctgtggccc ctcctgcccc taaacctacc 2220
caggccgggg agggaacact gtctgaggcc ctgctgcagc tccagttcga cgacgaggat 2280
ctgggagcac tgctgggcaa tagcaccgac cccgccgtgt ttaccgacct ggcctccgtg 2340
gacaacagcg agttccagca gctcctcaac cagggcatcc ctgtcgcccc acacaccacc 2400
gagcccatgc tgatggaata ccccgaggcc atcaccagac tggtcacagg cgcccagagg 2460
cctccagatc cagcaccagc tccactggga gcccctggcc tgcctaatgg gctgctgtct 2520
ggcgacgagg acttcgagag cattgccgac atggacttca gcgccctgct gtcccagatc 2580
agcagc                                                            2586

<210> 23
<211> 138
<212> DNA
<213> Unknown

<220> 
<223> 7xHBD/mE1B promoter

<400> 23
tagttaataa tctacaatag ttaataatct acaatagtta ataatctaca atagttaata 60
atctacaata gttaataatc tacaatagtt aataatctac aatagttaat aatctacaag 120
agctcagggt atataatg                                               138

<210> 24
<211> 1941
<212> DNA
<213> Unknown

<220> 
<223> HEA4(VP64) chimeric transcription factor

<400> 24
atggtgtcca agctgtccca gctgcagaca gaactgctgg cagcactgct ggaaagcggc 60
ctgagcaaag aggccctgat tcaggcactc ggcgaacctg gaccttatct gctcgctggc 120
gaaggccctc tggataaggg cgagagctgt ggcggaggaa gaggagagct ggccgagctg 180
cctaacggcc tgggcgagac aagaggcagc gaggacgaga cagacgacga cggcgaggac 240
ttcacccccc ccatcctgaa agagctggaa aacctgagcc ccgaggaagc cgcccaccag 300
aaagccgtgg tggagacact gctgcaggaa gatccctggc gggtcgccaa gatggtcaag 360
agctacctgc agcagcacaa catcccccag cgggaggtgg tggacaccac cggcctgaac 420
cagagccacc tgagccagca cctgaacaag ggcaccccca tgaaaaccca gaagagagcc 480
gccctgtaca cttggtacgt gcggaagcag agagaggtgg cccagcagtt tacacacgcc 540
ggccagggcg gcctgatcga ggaacctacc ggcgacgagc tgcccaccaa gaagggcaga 600
cggaaccggt ttaagtgggg ccctgcatct cagcagatcc tgttccaggc ctacgagcgg 660
cagaagaacc ccagcaaaga ggaacgggag acactggtgg aagagtgcaa ccgggccgag 720
tgcatccaga gaggcgtgag cccttctcag gctcagggcc tcggcagcaa tctggtcacc 780
gaagtgcggg tgtacaattg gttcgccaac cggcggaaag aggaagcctt ccggcacaag 840
ctgtctgctg gcgatatgag agccgccaac ctgtggccca gccccctgat gatcaagcgg 900
agcaagaaga acagcctggc cctgagcctg accgccgatc agatggtgtc cgctctgctg 960
gacgccgagc cccctatcct gtacagcgag tacgacccca ccagaccctt cagcgaggcc 1020
agcatgatgg gcctgctgac caacctggcc gaccgggagc tggtgcacat gatcaactgg 1080
gccaagcggg tgcccggctt cgtggacctg accctgcacg accaggtcca cctgctggaa 1140
tgtgcctggc tggaaatcct gatgatcggc ctcgtgtgga gaagcatgga acaccccgtg 1200
aagctgctgt tcgcccccaa cctgctcctg gaccggaacc agggaaagtg cgtggagggc 1260
atggtggaga tcttcgacat gctgctggcc acctccagcc ggttccggat gatgaacctg 1320
cagggcgagg aattcgtgtg cctgaagtcc atcatcctgc tgaacagcgg cgtgtacacc 1380
ttcctgtcat ccaccctgaa gtccctggaa gagaaggacc acatccaccg ggtgctggac 1440
aagatcaccg acaccctgat ccacctgatg gccaaggctg gcctgacact ccagcagcag 1500
caccagagac tggcccagct gctgctgatc ctgagccaca tccggcacat gagcaacaag 1560
ggaatggaac acctgtacag catgaagtgc aagaacgtgg tgcccctgta cgacctgctg 1620
ctcgaggctg ccgatgccca cagactgcac gcccctacaa gcagaggcgg agccagcgtg 1680
gaggaaaccg accagtctca cctggccacc gccggcagca caagcagcca cagcctgcag 1740
aagtactaca tcaccggcga ggccgaggga ttccctgcca ccgtggacgc tctggacgac 1800
ttcgaccttg acatgttggg ttccgacgcg ctggatgatt ttgatttgga catgctggga 1860
agcgacgcac tggatgactt tgatctcgat atgctcggct ctgacgcatt ggacgacttc 1920
gacttggata tgctgggttc t                                           1941

<210> 25
<211> 647
<212> PRT
<213> Artificial Sequence

<220> 
<223> HEA4(VP64) chimeric transcription factor

<400> 25
Met Val Ser Lys Leu Ser Gln Leu Gln Thr Glu Leu Leu Ala Ala Leu
 1               5                  10                  15      
Leu Glu Ser Gly Leu Ser Lys Glu Ala Leu Ile Gln Ala Leu Gly Glu
            20                  25                  30          
Pro Gly Pro Tyr Leu Leu Ala Gly Glu Gly Pro Leu Asp Lys Gly Glu
        35                  40                  45              
Ser Cys Gly Gly Gly Arg Gly Glu Leu Ala Glu Leu Pro Asn Gly Leu
    50                  55                  60                  
Gly Glu Thr Arg Gly Ser Glu Asp Glu Thr Asp Asp Asp Gly Glu Asp
65                  70                  75                  80  
Phe Thr Pro Pro Ile Leu Lys Glu Leu Glu Asn Leu Ser Pro Glu Glu
                85                  90                  95      
Ala Ala His Gln Lys Ala Val Val Glu Thr Leu Leu Gln Glu Asp Pro
            100                 105                 110         
Trp Arg Val Ala Lys Met Val Lys Ser Tyr Leu Gln Gln His Asn Ile
        115                 120                 125             
Pro Gln Arg Glu Val Val Asp Thr Thr Gly Leu Asn Gln Ser His Leu
    130                 135                 140                 
Ser Gln His Leu Asn Lys Gly Thr Pro Met Lys Thr Gln Lys Arg Ala
145                 150                 155                 160 
Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln Arg Glu Val Ala Gln Gln
                165                 170                 175     
Phe Thr His Ala Gly Gln Gly Gly Leu Ile Glu Glu Pro Thr Gly Asp
            180                 185                 190         
Glu Leu Pro Thr Lys Lys Gly Arg Arg Asn Arg Phe Lys Trp Gly Pro
        195                 200                 205             
Ala Ser Gln Gln Ile Leu Phe Gln Ala Tyr Glu Arg Gln Lys Asn Pro
    210                 215                 220                 
Ser Lys Glu Glu Arg Glu Thr Leu Val Glu Glu Cys Asn Arg Ala Glu
225                 230                 235                 240 
Cys Ile Gln Arg Gly Val Ser Pro Ser Gln Ala Gln Gly Leu Gly Ser
                245                 250                 255     
Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg
            260                 265                 270         
Lys Glu Glu Ala Phe Arg His Lys Leu Ser Ala Gly Asp Met Arg Ala
        275                 280                 285             
Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn
    290                 295                 300                 
Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu
305                 310                 315                 320 
Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro
                325                 330                 335     
Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg
            340                 345                 350         
Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val
        355                 360                 365             
Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu
    370                 375                 380                 
Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Val
385                 390                 395                 400 
Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys
                405                 410                 415     
Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser
            420                 425                 430         
Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu
        435                 440                 445             
Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser
    450                 455                 460                 
Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp
465                 470                 475                 480 
Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr
                485                 490                 495     
Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser
            500                 505                 510         
His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met
        515                 520                 525             
Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Ala Ala
    530                 535                 540                 
Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val
545                 550                 555                 560 
Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser
                565                 570                 575     
His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro
            580                 585                 590         
Ala Thr Val Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser
        595                 600                 605             
Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu
    610                 615                 620                 
Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe
625                 630                 635                 640 
Asp Leu Asp Met Leu Gly Ser
                645         


<210> 26
<211> 2262
<212> DNA
<213> Unknown

<220> 
<223> HEA4(HSF-1) chimeric transcription factor

<400> 26
atggtgtcca agctgtccca gctgcagaca gaactgctgg cagcactgct ggaaagcggc 60
ctgagcaaag aggccctgat tcaggcactc ggcgaacctg gaccttatct gctcgctggc 120
gaaggccctc tggataaggg cgagagctgt ggcggaggaa gaggagagct ggccgagctg 180
cctaacggcc tgggcgagac aagaggcagc gaggacgaga cagacgacga cggcgaggac 240
ttcacccccc ccatcctgaa agagctggaa aacctgagcc ccgaggaagc cgcccaccag 300
aaagccgtgg tggagacact gctgcaggaa gatccctggc gggtcgccaa gatggtcaag 360
agctacctgc agcagcacaa catcccccag cgggaggtgg tggacaccac cggcctgaac 420
cagagccacc tgagccagca cctgaacaag ggcaccccca tgaaaaccca gaagagagcc 480
gccctgtaca cttggtacgt gcggaagcag agagaggtgg cccagcagtt tacacacgcc 540
ggccagggcg gcctgatcga ggaacctacc ggcgacgagc tgcccaccaa gaagggcaga 600
cggaaccggt ttaagtgggg ccctgcatct cagcagatcc tgttccaggc ctacgagcgg 660
cagaagaacc ccagcaaaga ggaacgggag acactggtgg aagagtgcaa ccgggccgag 720
tgcatccaga gaggcgtgag cccttctcag gctcagggcc tcggcagcaa tctggtcacc 780
gaagtgcggg tgtacaattg gttcgccaac cggcggaaag aggaagcctt ccggcacaag 840
ctgtctgctg gcgatatgag agccgccaac ctgtggccca gccccctgat gatcaagcgg 900
agcaagaaga acagcctggc cctgagcctg accgccgatc agatggtgtc cgctctgctg 960
gacgccgagc cccctatcct gtacagcgag tacgacccca ccagaccctt cagcgaggcc 1020
agcatgatgg gcctgctgac caacctggcc gaccgggagc tggtgcacat gatcaactgg 1080
gccaagcggg tgcccggctt cgtggacctg accctgcacg accaggtcca cctgctggaa 1140
tgtgcctggc tggaaatcct gatgatcggc ctcgtgtgga gaagcatgga acaccccgtg 1200
aagctgctgt tcgcccccaa cctgctcctg gaccggaacc agggaaagtg cgtggagggc 1260
atggtggaga tcttcgacat gctgctggcc acctccagcc ggttccggat gatgaacctg 1320
cagggcgagg aattcgtgtg cctgaagtcc atcatcctgc tgaacagcgg cgtgtacacc 1380
ttcctgtcat ccaccctgaa gtccctggaa gagaaggacc acatccaccg ggtgctggac 1440
aagatcaccg acaccctgat ccacctgatg gccaaggctg gcctgacact ccagcagcag 1500
caccagagac tggcccagct gctgctgatc ctgagccaca tccggcacat gagcaacaag 1560
ggaatggaac acctgtacag catgaagtgc aagaacgtgg tgcccctgta cgacctgctg 1620
ctcgaggctg ccgatgccca cagactgcac gcccctacaa gcagaggcgg agccagcgtg 1680
gaggaaaccg accagtctca cctggccacc gccggcagca caagcagcca cagcctgcag 1740
aagtactaca tcaccggcga ggccgaggga ttccctgcca ccgtggaaaa gtgcctcagc 1800
gtagcctgcc tggacaagaa tgagctcagt gaccacttgg atgctatgga ctccaacctg 1860
gataacctgc agaccatgct gagcagccac ggcttcagcg tggacaccag tgccctgctg 1920
gacctgttca gcccctcggt gaccgtgccc gacatgagcc tgcctgacct tgacagcagc 1980
ctggccagta tccaagagct cctgtctccc caggagcccc ccaggcctcc cgaggcagag 2040
aacagcagcc cggattcagg gaagcagctg gtgcactaca cagcgcagcc gctgttcctg 2100
ctggaccccg gctccgtgga caccgggagc aacgacctgc cggtgctgtt tgagctggga 2160
gagggctcct acttctccga aggggacggc ttcgccgagg accccaccat ctccctgctg 2220
acaggctcgg agcctcccaa agccaaggac cccactgtct cc                    2262

<210> 27
<211> 754
<212> PRT
<213> Artificial Sequence

<220> 
<223> HEA4(HSF-1) chimeric transcription factor

<400> 27
Met Val Ser Lys Leu Ser Gln Leu Gln Thr Glu Leu Leu Ala Ala Leu
 1               5                  10                  15      
Leu Glu Ser Gly Leu Ser Lys Glu Ala Leu Ile Gln Ala Leu Gly Glu
            20                  25                  30          
Pro Gly Pro Tyr Leu Leu Ala Gly Glu Gly Pro Leu Asp Lys Gly Glu
        35                  40                  45              
Ser Cys Gly Gly Gly Arg Gly Glu Leu Ala Glu Leu Pro Asn Gly Leu
    50                  55                  60                  
Gly Glu Thr Arg Gly Ser Glu Asp Glu Thr Asp Asp Asp Gly Glu Asp
65                  70                  75                  80  
Phe Thr Pro Pro Ile Leu Lys Glu Leu Glu Asn Leu Ser Pro Glu Glu
                85                  90                  95      
Ala Ala His Gln Lys Ala Val Val Glu Thr Leu Leu Gln Glu Asp Pro
            100                 105                 110         
Trp Arg Val Ala Lys Met Val Lys Ser Tyr Leu Gln Gln His Asn Ile
        115                 120                 125             
Pro Gln Arg Glu Val Val Asp Thr Thr Gly Leu Asn Gln Ser His Leu
    130                 135                 140                 
Ser Gln His Leu Asn Lys Gly Thr Pro Met Lys Thr Gln Lys Arg Ala
145                 150                 155                 160 
Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln Arg Glu Val Ala Gln Gln
                165                 170                 175     
Phe Thr His Ala Gly Gln Gly Gly Leu Ile Glu Glu Pro Thr Gly Asp
            180                 185                 190         
Glu Leu Pro Thr Lys Lys Gly Arg Arg Asn Arg Phe Lys Trp Gly Pro
        195                 200                 205             
Ala Ser Gln Gln Ile Leu Phe Gln Ala Tyr Glu Arg Gln Lys Asn Pro
    210                 215                 220                 
Ser Lys Glu Glu Arg Glu Thr Leu Val Glu Glu Cys Asn Arg Ala Glu
225                 230                 235                 240 
Cys Ile Gln Arg Gly Val Ser Pro Ser Gln Ala Gln Gly Leu Gly Ser
                245                 250                 255     
Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg
            260                 265                 270         
Lys Glu Glu Ala Phe Arg His Lys Leu Ser Ala Gly Asp Met Arg Ala
        275                 280                 285             
Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn
    290                 295                 300                 
Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu
305                 310                 315                 320 
Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro
                325                 330                 335     
Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg
            340                 345                 350         
Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val
        355                 360                 365             
Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu
    370                 375                 380                 
Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Val
385                 390                 395                 400 
Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys
                405                 410                 415     
Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser
            420                 425                 430         
Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu
        435                 440                 445             
Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser
    450                 455                 460                 
Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp
465                 470                 475                 480 
Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr
                485                 490                 495     
Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser
            500                 505                 510         
His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met
        515                 520                 525             
Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Ala Ala
    530                 535                 540                 
Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val
545                 550                 555                 560 
Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser
                565                 570                 575     
His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro
            580                 585                 590         
Ala Thr Val Glu Lys Cys Leu Ser Val Ala Cys Leu Asp Lys Asn Glu
        595                 600                 605             
Leu Ser Asp His Leu Asp Ala Met Asp Ser Asn Leu Asp Asn Leu Gln
    610                 615                 620                 
Thr Met Leu Ser Ser His Gly Phe Ser Val Asp Thr Ser Ala Leu Leu
625                 630                 635                 640 
Asp Leu Phe Ser Pro Ser Val Thr Val Pro Asp Met Ser Leu Pro Asp
                645                 650                 655     
Leu Asp Ser Ser Leu Ala Ser Ile Gln Glu Leu Leu Ser Pro Gln Glu
            660                 665                 670         
Pro Pro Arg Pro Pro Glu Ala Glu Asn Ser Ser Pro Asp Ser Gly Lys
        675                 680                 685             
Gln Leu Val His Tyr Thr Ala Gln Pro Leu Phe Leu Leu Asp Pro Gly
    690                 695                 700                 
Ser Val Asp Thr Gly Ser Asn Asp Leu Pro Val Leu Phe Glu Leu Gly
705                 710                 715                 720 
Glu Gly Ser Tyr Phe Ser Glu Gly Asp Gly Phe Ala Glu Asp Pro Thr
                725                 730                 735     
Ile Ser Leu Leu Thr Gly Ser Glu Pro Pro Lys Ala Lys Asp Pro Thr
            740                 745                 750         
Val Ser
    


<210> 28
<211> 1887
<212> DNA
<213> Unknown

<220> 
<223> HEA4(Arnt) chimeric transcription factor

<400> 28
atggtgtcca agctgtccca gctgcagaca gaactgctgg cagcactgct ggaaagcggc 60
ctgagcaaag aggccctgat tcaggcactc ggcgaacctg gaccttatct gctcgctggc 120
gaaggccctc tggataaggg cgagagctgt ggcggaggaa gaggagagct ggccgagctg 180
cctaacggcc tgggcgagac aagaggcagc gaggacgaga cagacgacga cggcgaggac 240
ttcacccccc ccatcctgaa agagctggaa aacctgagcc ccgaggaagc cgcccaccag 300
aaagccgtgg tggagacact gctgcaggaa gatccctggc gggtcgccaa gatggtcaag 360
agctacctgc agcagcacaa catcccccag cgggaggtgg tggacaccac cggcctgaac 420
cagagccacc tgagccagca cctgaacaag ggcaccccca tgaaaaccca gaagagagcc 480
gccctgtaca cttggtacgt gcggaagcag agagaggtgg cccagcagtt tacacacgcc 540
ggccagggcg gcctgatcga ggaacctacc ggcgacgagc tgcccaccaa gaagggcaga 600
cggaaccggt ttaagtgggg ccctgcatct cagcagatcc tgttccaggc ctacgagcgg 660
cagaagaacc ccagcaaaga ggaacgggag acactggtgg aagagtgcaa ccgggccgag 720
tgcatccaga gaggcgtgag cccttctcag gctcagggcc tcggcagcaa tctggtcacc 780
gaagtgcggg tgtacaattg gttcgccaac cggcggaaag aggaagcctt ccggcacaag 840
ctgtctgctg gcgatatgag agccgccaac ctgtggccca gccccctgat gatcaagcgg 900
agcaagaaga acagcctggc cctgagcctg accgccgatc agatggtgtc cgctctgctg 960
gacgccgagc cccctatcct gtacagcgag tacgacccca ccagaccctt cagcgaggcc 1020
agcatgatgg gcctgctgac caacctggcc gaccgggagc tggtgcacat gatcaactgg 1080
gccaagcggg tgcccggctt cgtggacctg accctgcacg accaggtcca cctgctggaa 1140
tgtgcctggc tggaaatcct gatgatcggc ctcgtgtgga gaagcatgga acaccccgtg 1200
aagctgctgt tcgcccccaa cctgctcctg gaccggaacc agggaaagtg cgtggagggc 1260
atggtggaga tcttcgacat gctgctggcc acctccagcc ggttccggat gatgaacctg 1320
cagggcgagg aattcgtgtg cctgaagtcc atcatcctgc tgaacagcgg cgtgtacacc 1380
ttcctgtcat ccaccctgaa gtccctggaa gagaaggacc acatccaccg ggtgctggac 1440
aagatcaccg acaccctgat ccacctgatg gccaaggctg gcctgacact ccagcagcag 1500
caccagagac tggcccagct gctgctgatc ctgagccaca tccggcacat gagcaacaag 1560
ggaatggaac acctgtacag catgaagtgc aagaacgtgg tgcccctgta cgacctgctg 1620
ctcgaggctg ccgatgccca cagactgcac gcccctacaa gcagaggcgg agccagcgtg 1680
gaggaaaccg accagtctca cctggccacc gccggcagca caagcagcca cagcctgcag 1740
aagtactaca tcaccggcga ggccgaggga ttccctgcca ccgtgcctga ggtcttccag 1800
gagatgctgt ccatgctggg agatcagagc aacagctaca acaatgaaga attccctgat 1860
ctaactatgt ttcccccctt ttcagaa                                     1887

<210> 29
<211> 629
<212> PRT
<213> Artificial Sequence

<220> 
<223> HEA4(Arnt) chimeric transcription factor

<400> 29
Met Val Ser Lys Leu Ser Gln Leu Gln Thr Glu Leu Leu Ala Ala Leu
 1               5                  10                  15      
Leu Glu Ser Gly Leu Ser Lys Glu Ala Leu Ile Gln Ala Leu Gly Glu
            20                  25                  30          
Pro Gly Pro Tyr Leu Leu Ala Gly Glu Gly Pro Leu Asp Lys Gly Glu
        35                  40                  45              
Ser Cys Gly Gly Gly Arg Gly Glu Leu Ala Glu Leu Pro Asn Gly Leu
    50                  55                  60                  
Gly Glu Thr Arg Gly Ser Glu Asp Glu Thr Asp Asp Asp Gly Glu Asp
65                  70                  75                  80  
Phe Thr Pro Pro Ile Leu Lys Glu Leu Glu Asn Leu Ser Pro Glu Glu
                85                  90                  95      
Ala Ala His Gln Lys Ala Val Val Glu Thr Leu Leu Gln Glu Asp Pro
            100                 105                 110         
Trp Arg Val Ala Lys Met Val Lys Ser Tyr Leu Gln Gln His Asn Ile
        115                 120                 125             
Pro Gln Arg Glu Val Val Asp Thr Thr Gly Leu Asn Gln Ser His Leu
    130                 135                 140                 
Ser Gln His Leu Asn Lys Gly Thr Pro Met Lys Thr Gln Lys Arg Ala
145                 150                 155                 160 
Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln Arg Glu Val Ala Gln Gln
                165                 170                 175     
Phe Thr His Ala Gly Gln Gly Gly Leu Ile Glu Glu Pro Thr Gly Asp
            180                 185                 190         
Glu Leu Pro Thr Lys Lys Gly Arg Arg Asn Arg Phe Lys Trp Gly Pro
        195                 200                 205             
Ala Ser Gln Gln Ile Leu Phe Gln Ala Tyr Glu Arg Gln Lys Asn Pro
    210                 215                 220                 
Ser Lys Glu Glu Arg Glu Thr Leu Val Glu Glu Cys Asn Arg Ala Glu
225                 230                 235                 240 
Cys Ile Gln Arg Gly Val Ser Pro Ser Gln Ala Gln Gly Leu Gly Ser
                245                 250                 255     
Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg
            260                 265                 270         
Lys Glu Glu Ala Phe Arg His Lys Leu Ser Ala Gly Asp Met Arg Ala
        275                 280                 285             
Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn
    290                 295                 300                 
Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu
305                 310                 315                 320 
Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro
                325                 330                 335     
Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg
            340                 345                 350         
Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val
        355                 360                 365             
Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu
    370                 375                 380                 
Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Val
385                 390                 395                 400 
Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys
                405                 410                 415     
Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser
            420                 425                 430         
Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu
        435                 440                 445             
Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser
    450                 455                 460                 
Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp
465                 470                 475                 480 
Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr
                485                 490                 495     
Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser
            500                 505                 510         
His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met
        515                 520                 525             
Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Ala Ala
    530                 535                 540                 
Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val
545                 550                 555                 560 
Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser
                565                 570                 575     
His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro
            580                 585                 590         
Ala Thr Val Pro Glu Val Phe Gln Glu Met Leu Ser Met Leu Gly Asp
        595                 600                 605             
Gln Ser Asn Ser Tyr Asn Asn Glu Glu Phe Pro Asp Leu Thr Met Phe
    610                 615                 620                 
Pro Pro Phe Ser Glu
625                 


<210> 30
<211> 1074
<212> DNA
<213> Unknown

<220> 
<223> EGFRt nucleotide sequence

<400> 30
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atcccacgca aagtgtgtaa cggaataggt attggtgaat ttaaagactc actctccata 120
aatgctacga atattaaaca cttcaaaaac tgcacctcca tcagtggcga tctccacatc 180
ctgccggtgg catttagggg tgactccttc acacatactc ctcctctgga tccacaggaa 240
ctggatattc tgaaaaccgt aaaggaaatc acagggtttt tgctgattca ggcttggcct 300
gaaaacagga cggacctcca tgcctttgag aacctagaaa tcatacgcgg caggaccaag 360
caacatggtc agttttctct tgcagtcgtc agcctgaaca taacatcctt gggattacgc 420
tccctcaagg agataagtga tggagatgtg ataatttcag gaaacaaaaa tttgtgctat 480
gcaaatacaa taaactggaa aaaactgttt gggacctccg gtcagaaaac caaaattata 540
agcaacagag gtgaaaacag ctgcaaggcc acaggccagg tctgccatgc cttgtgctcc 600
cccgagggct gctggggccc ggagcccagg gactgcgtct cttgccggaa tgtcagccga 660
ggcagggaat gcgtggacaa gtgcaacctt ctggagggtg agccaaggga gtttgtggag 720
aactctgagt gcatacagtg ccacccagag tgcctgcctc aggccatgaa catcacctgc 780
acaggacggg gaccagacaa ctgtatccag tgtgcccact acattgacgg cccccactgc 840
gtcaagacct gcccggcagg agtcatggga gaaaacaaca ccctggtctg gaagtacgca 900
gacgccggcc atgtgtgcca cctgtgccat ccaaactgca cctacggatg cactgggcca 960
ggtcttgaag gctgtccaac gaatgggcct aagatcccgt ccatcgccac tgggatggtg 1020
ggggccctcc tcttgctgct ggtggtggcc ctggggatcg gcctcttcat gtga       1074

<210> 31
<211> 357
<212> PRT
<213> Artificial Sequence

<220> 
<223> EGFRt amino acid sequence

<220> 
<223> EGFRt amino acid sequence

<400> 31
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly
            20                  25                  30          
Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe
        35                  40                  45              
Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala
    50                  55                  60                  
Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu
65                  70                  75                  80  
Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile
                85                  90                  95      
Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu
            100                 105                 110         
Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala
        115                 120                 125             
Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu
    130                 135                 140                 
Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr
145                 150                 155                 160 
Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys
                165                 170                 175     
Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly
            180                 185                 190         
Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu
        195                 200                 205             
Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys
    210                 215                 220                 
Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu
225                 230                 235                 240 
Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met
                245                 250                 255     
Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala
            260                 265                 270         
His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val
        275                 280                 285             
Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His
    290                 295                 300                 
Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro
305                 310                 315                 320 
Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala
                325                 330                 335     
Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly
            340                 345                 350         
Ile Gly Leu Phe Met
        355         


<210> 32
<211> 408
<212> DNA
<213> Unknown

<220> 
<223> Her2t

<400> 32
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atcccatgcc accctgagtg tcagccccag aatggctcag tgacctgttt tggaccggag 120
gctgaccagt gtgtggcctg tgcccactat aaggaccctc ccttctgcgt ggcccgctgc 180
cccagcggtg tgaaacctga cctctcctac atgcccatct ggaagtttcc agatgaggag 240
ggcgcatgcc agccttgccc catcaactgc acccactcct gtgtggacct ggatgacaag 300
ggctgccccg ccgagcagag agccagccct ctgacgtcca tcatctctgc ggtggttggc 360
attctgctgg tcgtggtctt gggggtggtc tttgggatcc tcatctga              408

<210> 33
<211> 135
<212> PRT
<213> Artificial Sequence

<220> 
<223> Her2t

<400> 33
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly
            20                  25                  30          
Ser Val Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala
        35                  40                  45              
His Tyr Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val
    50                  55                  60                  
Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu
65                  70                  75                  80  
Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp
                85                  90                  95      
Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr
            100                 105                 110         
Ser Ile Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly
        115                 120                 125             
Val Val Phe Gly Ile Leu Ile
    130                 135 


<210> 34
<211> 429
<212> DNA
<213> Unknown

<220> 
<223> Her2tG

<400> 34
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atcccatgcc accctgagtg tcagccccag aatggctcag tgacctgttt tggaccggag 120
gctgaccagt gtgtggcctg tgcccactat aaggaccctc ccttctgcgt ggcccgctgc 180
cccagcggtg tgaaacctga cctctcctac atgcccatct ggaagtttcc agatgaggag 240
ggcgcatgcc agccttgccc catcaactgc acccactcct gtgtggacct ggatgacaag 300
ggctgccccg ccgagcagag agccagcccg ttaacgggtg gaggcagcgg aggtggctcc 360
atcatctctg cggtggttgg cattctgctg gtcgtggtct tgggggtggt ctttgggatc 420
ctcatctga                                                         429

<210> 35
<211> 142
<212> PRT
<213> Artificial Sequence

<220> 
<223> Her2tG

<400> 35
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly
            20                  25                  30          
Ser Val Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala
        35                  40                  45              
His Tyr Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val
    50                  55                  60                  
Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu
65                  70                  75                  80  
Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp
                85                  90                  95      
Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr
            100                 105                 110         
Gly Gly Gly Ser Gly Gly Gly Ser Ile Ile Ser Ala Val Val Gly Ile
        115                 120                 125             
Leu Leu Val Val Val Leu Gly Val Val Phe Gly Ile Leu Ile
    130                 135                 140         


<210> 36
<211> 972
<212> DNA
<213> Unknown

<220> 
<223> CD19t

<400> 36
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc 60
gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag 120
gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc 180
ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggccatc 240
tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg 300
cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag 360
ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc 420
tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc 480
aaagaccgcc ctgagatctg ggagggagag cctccgtgtg tcccaccgag ggacagcctg 540
aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt 600
ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag 660
gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg 720
gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat 780
tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta 840
tggcactggc tgctgaggac tggtggctgg aaggtctcag ctgtgacttt ggcttatctg 900
atcttctgcc tgtgttccct tgtgggcatt cttcatcttc aaagagccct ggtcctgagg 960
aggaaaagat aa                                                     972

<210> 37
<211> 323
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD19t

<400> 37
Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met
 1               5                  10                  15      
Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp
            20                  25                  30          
Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln
        35                  40                  45              
Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu
    50                  55                  60                  
Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile
65                  70                  75                  80  
Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu
                85                  90                  95      
Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr
            100                 105                 110         
Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp
        115                 120                 125             
Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro
    130                 135                 140                 
Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala
145                 150                 155                 160 
Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Val Pro Pro
                165                 170                 175     
Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro
            180                 185                 190         
Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser
        195                 200                 205             
Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser
    210                 215                 220                 
Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp
225                 230                 235                 240 
Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala
                245                 250                 255     
Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu
            260                 265                 270         
Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly
        275                 280                 285             
Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu
    290                 295                 300                 
Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg
305                 310                 315                 320 
Arg Lys Arg
            


<210> 38
<211> 561
<212> DNA
<213> Unknown

<220> 
<223> DHFRdm

<400> 38
atggttggtt cgctaaactg catcgtcgct gtgtcccaga acatgggcat cggcaagaac 60
ggggacttcc cctggccacc gctcaggaat gaatccagat atttccagag aatgaccaca 120
acctcttcag tagaaggtaa acagaatctg gtgattatgg gtaagaagac ctggttctcc 180
attcctgaga agaatcgacc tttaaagggt agaattaatt tagttctcag cagagaactc 240
aaggaacctc cacaaggagc tcattttctt tccagaagtc tagatgatgc cttaaaactt 300
actgaacaac cagaattagc aaataaagta gacatggtct ggatagttgg tggcagttct 360
gtttataagg aagccatgaa tcacccaggc catcttaaac tatttgtgac aaggatcatg 420
caagactttg aaagtgacac gttttttcca gaaattgatt tggagaaata taaacttctg 480
ccagaatacc caggtgttct ctctgatgtc caggaggaga aaggcattaa gtacaaattt 540
gaagtatatg agaagaatga t                                           561

<210> 39
<211> 186
<212> PRT
<213> Artificial Sequence

<220> 
<223> DHFRdm

<400> 39
Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly Ile
 1               5                  10                  15      
Gly Lys Asn Gly Asp Phe Pro Trp Pro Pro Leu Arg Asn Glu Ser Arg
            20                  25                  30          
Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln Asn
        35                  40                  45              
Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys Asn
    50                  55                  60                  
Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu Lys
65                  70                  75                  80  
Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp Ala
                85                  90                  95      
Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met Val
            100                 105                 110         
Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His Pro
        115                 120                 125             
Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu Ser
    130                 135                 140                 
Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu Pro
145                 150                 155                 160 
Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile Lys
                165                 170                 175     
Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp
            180                 185     


<210> 40
<211> 804
<212> DNA
<213> Unknown

<220> 
<223> huCD19 scFv (G01S)

<400> 40
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atcccagagg tgcagctggt cgaatccgga ggaggactgg tccagcccgg ccggagcctg 120
agactgagct gtgccgcttc cggattcact tttgacgatt acgcaatgca ttgggtgagg 180
caggcccctg gcaaggggct ggaatgggtc tccggaatct cttggaacag tgggcgcatt 240
ggatatgccg attctgtgaa gggccgattc actatctctc gggacaacgc taaaaatagt 300
ctgtttctgc agatgaattc cctgcgcgcc gaggataccg ccgtgtacta ttgcgcccga 360
gaccagggct accactacta tgatagcgcc gaacatgcat tcgacatttg gggacaggga 420
actgtggtca ccgtgagctc cggaggagga ggaagcggag gaggagggtc cggaggcggg 480
ggatcacaga gcgcactgac ccagccacgg agcgtgagcg gatttcctgg gcagtctgtc 540
accattagtt gcacaggcac cacatcagac gatgtgagct ggtaccagca gcacccaggg 600
aaggctcccc agctgatgct gtatgacgtg tccaaaagac cttctggcgt cccacatagg 660
tttagtggaa gccggagcgg ccgggcagcc agtctgatca tttcagggct gcagacagag 720
gacgaagctg attatttctg ttctagttac gcaggcagat ataactctgt gctgtttggc 780
gggggaacaa agctgactgt cctg                                        804

<210> 41
<211> 268
<212> PRT
<213> Artificial Sequence

<220> 
<223> huCD19 scFv (G01S)

<400> 41
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly
            20                  25                  30          
Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
        35                  40                  45              
Phe Thr Phe Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly
    50                  55                  60                  
Lys Gly Leu Glu Trp Val Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile
65                  70                  75                  80  
Gly Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
                85                  90                  95      
Ala Lys Asn Ser Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
            100                 105                 110         
Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gln Gly Tyr His Tyr Tyr Asp
        115                 120                 125             
Ser Ala Glu His Ala Phe Asp Ile Trp Gly Gln Gly Thr Val Val Thr
    130                 135                 140                 
Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
145                 150                 155                 160 
Gly Ser Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Phe Pro
                165                 170                 175     
Gly Gln Ser Val Thr Ile Ser Cys Thr Gly Thr Thr Ser Asp Asp Val
            180                 185                 190         
Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Gln Leu Met Leu Tyr
        195                 200                 205             
Asp Val Ser Lys Arg Pro Ser Gly Val Pro His Arg Phe Ser Gly Ser
    210                 215                 220                 
Arg Ser Gly Arg Ala Ala Ser Leu Ile Ile Ser Gly Leu Gln Thr Glu
225                 230                 235                 240 
Asp Glu Ala Asp Tyr Phe Cys Ser Ser Tyr Ala Gly Arg Tyr Asn Ser
                245                 250                 255     
Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            260                 265             


<210> 42
<211> 801
<212> DNA
<213> Unknown

<220> 
<223> muCD19 (FMC63) scFv

<400> 42
atgctgctgc tggtgaccag cctgctgctg tgcgagctgc cccaccccgc ctttctgctg 60
atccccgaca tccagatgac ccagaccacc tccagcctga gcgccagcct gggcgaccgg 120
gtgaccatca gctgccgggc cagccaggac atcagcaagt acctgaactg gtatcagcag 180
aagcccgacg gcaccgtcaa gctgctgatc taccacacca gccggctgca cagcggcgtg 240
cccagccggt ttagcggcag cggctccggc accgactaca gcctgaccat ctccaacctg 300
gaacaggaag atatcgccac ctacttttgc cagcagggca acacactgcc ctacaccttt 360
ggcggcggaa caaagctgga aatcaccggc agcacctccg gcagcggcaa gcctggcagc 420
ggcgagggca gcaccaaggg cgaggtgaag ctgcaggaaa gcggccctgg cctggtggcc 480
cccagccaga gcctgagcgt gacctgcacc gtgagcggcg tgagcctgcc cgactacggc 540
gtgagctgga tccggcagcc ccccaggaag ggcctggaat ggctgggcgt gatctggggc 600
agcgagacca cctactacaa cagcgccctg aagagccggc tgaccatcat caaggacaac 660
agcaagagcc aggtgttcct gaagatgaac agcctgcaga ccgacgacac cgccatctac 720
tactgcgcca agcactacta ctacggcggc agctacgcca tggactactg gggccagggc 780
accagcgtga ccgtgagcag c                                           801

<210> 43
<211> 267
<212> PRT
<213> Artificial Sequence

<220> 
<223> muCD19 (FMC63) scFv

<400> 43
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser
            20                  25                  30          
Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser
        35                  40                  45              
Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly
    50                  55                  60                  
Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr
                85                  90                  95      
Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln
            100                 105                 110         
Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
        115                 120                 125             
Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser
    130                 135                 140                 
Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala
145                 150                 155                 160 
Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu
                165                 170                 175     
Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu
            180                 185                 190         
Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser
        195                 200                 205             
Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln
    210                 215                 220                 
Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr
225                 230                 235                 240 
Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr
                245                 250                 255     
Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
            260                 265         


<210> 44
<211> 798
<212> DNA
<213> Unknown

<220> 
<223> CD20 (Leu16) scFv

<400> 44
atggagacag acacactcct gctatgggtg ctgctgctct gggttccagg ttccacaggt 60
gacattgtgc tgacccaatc tccagctatc ctgtctgcat ctccagggga gaaggtcaca 120
atgacttgca gggccagctc aagtgtaaat tacatggact ggtaccagaa gaagccagga 180
tcctccccca aaccctggat ttatgccaca tccaacctgg cttctggagt ccctgctcgc 240
ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagagt ggaggctgaa 300
gatgctgcca cttattactg ccagcagtgg agttttaatc cacccacgtt cggagggggg 360
accaagctgg aaataaaagg cagtactagc ggtggtggct ccgggggcgg ttccggtggg 420
ggcggcagca gcgaggtgca gctgcagcag tctggggctg agctggtgaa gcctggggcc 480
tcagtgaaga tgtcctgcaa ggcttctggc tacacattta ccagttacaa tatgcactgg 540
gtaaagcaga cacctggaca gggcctggaa tggattggag ctatttatcc aggaaatggt 600
gatacttcct acaatcagaa gttcaaaggc aaggccacat tgactgcaga caaatcctcc 660
agcacagcct acatgcagct cagcagcctg acatctgagg actctgcgga ctattactgt 720
gcaagatcta attattacgg tagtagctac tggttcttcg atgtctgggg cgcagggacc 780
acggtcaccg tctcctca                                               798

<210> 45
<211> 266
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD20 (Leu16) scFv

<400> 45
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser
            20                  25                  30          
Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser
        35                  40                  45              
Val Asn Tyr Met Asp Trp Tyr Gln Lys Lys Pro Gly Ser Ser Pro Lys
    50                  55                  60                  
Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg
65                  70                  75                  80  
Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg
                85                  90                  95      
Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Phe
            100                 105                 110         
Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Ser
        115                 120                 125             
Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser
    130                 135                 140                 
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala
145                 150                 155                 160 
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
                165                 170                 175     
Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile
            180                 185                 190         
Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe
        195                 200                 205             
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
    210                 215                 220                 
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Asp Tyr Tyr Cys
225                 230                 235                 240 
Ala Arg Ser Asn Tyr Tyr Gly Ser Ser Tyr Trp Phe Phe Asp Val Trp
                245                 250                 255     
Gly Ala Gly Thr Thr Val Thr Val Ser Ser
            260                 265     


<210> 46
<211> 810
<212> DNA
<213> Unknown

<220> 
<223> CD22 (m971) scFv

<400> 46
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atcccacagg tacagctgca gcagtcaggt ccaggactgg tgaagccctc gcagaccctc 120
tcactcacct gtgccatctc cggggacagt gtctctagca acagtgctgc ttggaactgg 180
atcaggcagt ccccatcgag aggccttgag tggctgggaa ggacatacta caggtccaag 240
tggtataatg attatgcagt atctgtgaaa agtcgaataa ccatcaaccc agacacatcc 300
aagaaccagt tctccctgca gctgaactct gtgactcccg aggacacggc tgtgtattac 360
tgtgcaagag aagtgactgg ggatctcgag gatgcttttg atatctgggg ccaagggaca 420
atggtcaccg tctcctcagg cggagggggc tctggcggcg gaggatctgg gggagggggc 480
agcgacatcc agatgaccca gtctccatcg tccctgtctg catctgtagg agacagagtc 540
accatcactt gccgggcaag ccagaccatt tggagctact taaattggta tcagcagaga 600
ccagggaaag cccctaacct cctgatctat gctgcatcca gtttgcaaag tggggtccca 660
tcaaggttca gtggcagggg atctgggaca gatttcactc tcaccatcag cagtctgcaa 720
gctgaagatt ttgcaactta ctactgtcaa cagagttaca gtatccctca gacttttggc 780
caggggacca agctggagat caaacgaact                                  810

<210> 47
<211> 270
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD22 (m971) scFv

<400> 47
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly
            20                  25                  30          
Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly
        35                  40                  45              
Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser
    50                  55                  60                  
Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys
65                  70                  75                  80  
Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Ile Thr Ile Asn
                85                  90                  95      
Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr
            100                 105                 110         
Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp
        115                 120                 125             
Leu Glu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val
    130                 135                 140                 
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
145                 150                 155                 160 
Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
                165                 170                 175     
Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser
            180                 185                 190         
Tyr Leu Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu
        195                 200                 205             
Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser
    210                 215                 220                 
Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
225                 230                 235                 240 
Ala Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro
                245                 250                 255     
Gln Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr
            260                 265                 270 


<210> 48
<211> 948
<212> DNA
<213> Unknown

<220> 
<223> B7H3 (hBRCA84D) scFv

<400> 48
atgctgcgtc ggcggggcag ccctggcatg ggtgtgcatg tgggtgcagc cctgggagca 60
ctgtggttct gcctcacagg agccctggag gtccaggtcc ctgaagaccc agtggtggca 120
ctggtgggca ccgatgccac cctgtgctgc tccttctccc ctgagcctgg cttcagcctg 180
gcacagctca acctcatctg gcagctgaca gataccaaac agctggtgca cagctttgct 240
gagggccagg accagggcag cgcctatgcc aaccgcacgg ccctcttccc ggacctgctg 300
gcacagggca acgcatccct gaggctgcag cgcgtgcgtg tggcggacga gggcagcttc 360
acctgcttcg tgagcatccg ggatttcggc agcgctgccg tcagcctgca ggtggccgct 420
ccctactcga agcccagcat gaccctggag cccaacaagg acctgcggcc aggggacacg 480
gtgaccatca cgtgctccag ctaccagggc taccctgagg ctgaggtgtt ctggcaggat 540
gggcagggtg tgcccctgac tggcaacgtg accacgtcgc agatggccaa cgagcagggc 600
ttgtttgatg tgcacagcat cctgcgggtg gtgctgggtg caaatggcac ctacagctgc 660
ctggtgcgca accccgtgct gcagcaggat gcgcacagct ctgtcaccat cacagggcag 720
cctatgacat tccccccaga ggccctgtgg gtgaccgtgg ggctgtctgt ctgtctcatt 780
gcactgctgg tggccctggc tttcgtgtgc tggagaaaga tcaaacagag ctgtgaggag 840
gagaatgcag gagctgagga ccaggatggg gagggagaag gctccaagac agccctgcag 900
cctctgaaac actctgacag caaagaagat gatggacaag aaatagcc              948

<210> 49
<211> 316
<212> PRT
<213> Artificial Sequence

<220> 
<223> B7H3 (hBRCA84D) scFv

<400> 49
Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala
 1               5                  10                  15      
Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln
            20                  25                  30          
Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu
        35                  40                  45              
Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn
    50                  55                  60                  
Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala
65                  70                  75                  80  
Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe
                85                  90                  95      
Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val
            100                 105                 110         
Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp
        115                 120                 125             
Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys
    130                 135                 140                 
Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr
145                 150                 155                 160 
Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val
                165                 170                 175     
Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr
            180                 185                 190         
Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu
        195                 200                 205             
Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn
    210                 215                 220                 
Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Gly Gln
225                 230                 235                 240 
Pro Met Thr Phe Pro Pro Glu Ala Leu Trp Val Thr Val Gly Leu Ser
                245                 250                 255     
Val Cys Leu Ile Ala Leu Leu Val Ala Leu Ala Phe Val Cys Trp Arg
            260                 265                 270         
Lys Ile Lys Gln Ser Cys Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln
        275                 280                 285             
Asp Gly Glu Gly Glu Gly Ser Lys Thr Ala Leu Gln Pro Leu Lys His
    290                 295                 300                 
Ser Asp Ser Lys Glu Asp Asp Gly Gln Glu Ile Ala
305                 310                 315     


<210> 50
<211> 792
<212> DNA
<213> Unknown

<220> 
<223> L1CAM (CE7) scFv

<400> 50
atgctgctgc tggtgaccag cctgctgctg tgcgagctgc cccaccccgc ctttctgctg 60
atcccccagg tgcagctgca gcagcctggc gccgagctgg tgaagccagg cgccagcgtg 120
aagctgtcct gcaaggccag cggctacacc ttcaccggct actggatgca ctgggtgaag 180
cagagacccg gccacggcct ggaatggatc ggcgagatca accccagcaa cggccggacc 240
aactacaacg agcggttcaa gagcaaggcc accctgaccg tggacaagag cagcaccacc 300
gccttcatgc agctgtccgg cctgaccagc gaggacagcg ccgtgtactt ctgcgccagg 360
gactactacg gcaccagcta caacttcgac tactggggcc agggcaccac actgaccgtg 420
agcagcggcg gagggggctc tggcggcgga ggatctgggg gagggggcag cgacatccag 480
atgacccaga gcagcagcag cttcagcgtg agcctgggcg accgggtgac catcacctgt 540
aaggccaacg aggacatcaa caaccggctg gcctggtatc agcagacccc cggcaacagc 600
cccaggctgc tgatcagcgg cgccaccaac ctggtgaccg gcgtgcccag ccggtttagc 660
ggcagcggct ccggcaagga ctacaccctg accatcacaa gcctgcaggc cgaggacttc 720
gccacctact actgccagca gtactggtcc acccccttca ccttcggcag cggcaccgag 780
ctggaaatca aa                                                     792

<210> 51
<211> 264
<212> PRT
<213> Artificial Sequence

<220> 
<223> L1CAM (CE7) scFv

<400> 51
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Pro Gly Ala Glu
            20                  25                  30          
Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly
        35                  40                  45              
Tyr Thr Phe Thr Gly Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly
    50                  55                  60                  
His Gly Leu Glu Trp Ile Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr
65                  70                  75                  80  
Asn Tyr Asn Glu Arg Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Lys
                85                  90                  95      
Ser Ser Thr Thr Ala Phe Met Gln Leu Ser Gly Leu Thr Ser Glu Asp
            100                 105                 110         
Ser Ala Val Tyr Phe Cys Ala Arg Asp Tyr Tyr Gly Thr Ser Tyr Asn
        115                 120                 125             
Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly
    130                 135                 140                 
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln
145                 150                 155                 160 
Met Thr Gln Ser Ser Ser Ser Phe Ser Val Ser Leu Gly Asp Arg Val
                165                 170                 175     
Thr Ile Thr Cys Lys Ala Asn Glu Asp Ile Asn Asn Arg Leu Ala Trp
            180                 185                 190         
Tyr Gln Gln Thr Pro Gly Asn Ser Pro Arg Leu Leu Ile Ser Gly Ala
        195                 200                 205             
Thr Asn Leu Val Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser
    210                 215                 220                 
Gly Lys Asp Tyr Thr Leu Thr Ile Thr Ser Leu Gln Ala Glu Asp Phe
225                 230                 235                 240 
Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Phe Thr Phe Gly
                245                 250                 255     
Ser Gly Thr Glu Leu Glu Ile Lys
            260                 


<210> 52
<211> 795
<212> DNA
<213> Unknown

<220> 
<223> EGFR (cetuximab) scFv

<400> 52
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atcccacagg tgcagctgaa acagagcggc ccgggcctgg tgcagccgag ccagagcctg 120
agcattacct gcaccgtgag cggctttagc ctgaccaact atggcgtgca ttgggtgcgc 180
cagagcccgg gcaaaggcct ggaatggctg ggcgtgattt ggagcggcgg caacaccgat 240
tataacaccc cgtttaccag ccgcctgagc attaacaaag ataacagcaa aagccaggtg 300
ttttttaaaa tgaacagcct gcagagcaac gataccgcga tttattattg cgcgcgcgcg 360
ctgacctatt atgattatga atttgcgtat tggggccagg gcaccctggt gaccgtgagc 420
gcgggcggcg gcggcagcgg cggcggcggc agcggcggcg gcggcagcga tattctgctg 480
acccagagcc cggtgattct gagcgtgagc ccgggcgaac gcgtgagctt tagctgccgc 540
gcgagccaga gcattggcac caacattcat tggtatcagc agcgcaccaa cggcagcccg 600
cgcctgctga ttaaatatgc gagcgaaagc attagcggca ttccgagccg ctttagcggc 660
agcggcagcg gcaccgattt taccctgagc attaacagcg tggaaagcga agatattgcg 720
gattattatt gccagcagaa caacaactgg ccgaccacct ttggcgcggg caccaaactg 780
gaactgaaac gcacc                                                  795

<210> 53
<211> 265
<212> PRT
<213> Artificial Sequence

<220> 
<223> EGFR scFv

<400> 53
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Lys Gln Ser Gly Pro Gly
            20                  25                  30          
Leu Val Gln Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly
        35                  40                  45              
Phe Ser Leu Thr Asn Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly
    50                  55                  60                  
Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp
65                  70                  75                  80  
Tyr Asn Thr Pro Phe Thr Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser
                85                  90                  95      
Lys Ser Gln Val Phe Phe Lys Met Asn Ser Leu Gln Ser Asn Asp Thr
            100                 105                 110         
Ala Ile Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe
        115                 120                 125             
Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly
    130                 135                 140                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Leu Leu
145                 150                 155                 160 
Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly Glu Arg Val Ser
                165                 170                 175     
Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp Tyr
            180                 185                 190         
Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser
        195                 200                 205             
Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
    210                 215                 220                 
Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser Glu Asp Ile Ala
225                 230                 235                 240 
Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly Ala
                245                 250                 255     
Gly Thr Lys Leu Glu Leu Lys Arg Thr
            260                 265 


<210> 54
<211> 792
<212> DNA
<213> Unknown

<220> 
<223> EGFRVIII (806) scFv

<400> 54
atgctgctgc tggtgacaag cctgctgctg tgcgagctgc cacaccctgc tttcctgctg 60
atccctgatg tgcagctgca ggaatcaggc ccaagcctgg tcaaaccctc ccagtctctg 120
agtctgacct gtacagtgac tgggtactcc atcacatctg atttcgcatg gaactggatt 180
aggcagtttc caggcaataa gctggagtgg atgggctaca tctcatatag cgggaacact 240
cgctataatc ccagtctgaa atcacggatc agcattacta gagacaccag caagaaccag 300
ttctttctgc agctgaattc cgtgaccatt gaggataccg ccacatacta ttgcgtcaca 360
gctggcagag gctttccata ctggggacag ggcacactgg tgactgtcag cgccggctcc 420
acctctggga gtggaaaacc tggctccggg gaaggatcta caaagggaga catcctgatg 480
actcagtccc caagctccat gtcagtgagc ctgggcgaca ccgtctctat tacatgtcac 540
tctagtcagg atatcaacag taatattggc tggctgcagc agcgacccgg caagtctttc 600
aaagggctga tctatcatgg aactaacctg gacgatgaag tgcctagcag attttccggc 660
tctgggagtg gagctgatta cagtctgacc atttcaagcc tggagtcaga agacttcgca 720
gattactatt gcgtccagta tgcccagttc ccctggactt ttggcggggg aaccaagctg 780
gagatcaaac gg                                                     792

<210> 55
<211> 264
<212> PRT
<213> Artificial Sequence

<220> 
<223> EGFRVIII (806) scFv

<400> 55
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Asp Val Gln Leu Gln Glu Ser Gly Pro Ser
            20                  25                  30          
Leu Val Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly
        35                  40                  45              
Tyr Ser Ile Thr Ser Asp Phe Ala Trp Asn Trp Ile Arg Gln Phe Pro
    50                  55                  60                  
Gly Asn Lys Leu Glu Trp Met Gly Tyr Ile Ser Tyr Ser Gly Asn Thr
65                  70                  75                  80  
Arg Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr
                85                  90                  95      
Ser Lys Asn Gln Phe Phe Leu Gln Leu Asn Ser Val Thr Ile Glu Asp
            100                 105                 110         
Thr Ala Thr Tyr Tyr Cys Val Thr Ala Gly Arg Gly Phe Pro Tyr Trp
        115                 120                 125             
Gly Gln Gly Thr Leu Val Thr Val Ser Ala Gly Ser Thr Ser Gly Ser
    130                 135                 140                 
Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Asp Ile Leu Met
145                 150                 155                 160 
Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly Asp Thr Val Ser
                165                 170                 175     
Ile Thr Cys His Ser Ser Gln Asp Ile Asn Ser Asn Ile Gly Trp Leu
            180                 185                 190         
Gln Gln Arg Pro Gly Lys Ser Phe Lys Gly Leu Ile Tyr His Gly Thr
        195                 200                 205             
Asn Leu Asp Asp Glu Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly
    210                 215                 220                 
Ala Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala
225                 230                 235                 240 
Asp Tyr Tyr Cys Val Gln Tyr Ala Gln Phe Pro Trp Thr Phe Gly Gly
                245                 250                 255     
Gly Thr Lys Leu Glu Ile Lys Arg
            260                 


<210> 56
<211> 777
<212> DNA
<213> Unknown

<220> 
<223> EphA2 (2A4) scFv

<400> 56
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atcccacagg tgcagctgtt ggagtctggg ggaggcttgg tacagcctgg ggggtccctg 120
agactctcct gtgcagcctc tggattcacc tttagcagct ataccatgtc ttgggtgcga 180
caggcccctg gacaagcgct tgagtggatg ggaaccatta gtagtcgtgg tacttacacc 240
tactatccag acagtgtgaa gggccgattc accatctcca gagacaacgc caagaactca 300
ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ctgtgtatta ctgtgcgaga 360
gaagctatct ttactcactg gggccgtggc accctggtca ccgtctcctc aggtggtggt 420
ggttctggcg gcggcggctc cggtggtggt ggttctgaca tccagttgac ccagtctcca 480
tcctccctgt ctgcatctgt aggagacaga gtcaccatca cttgcaaggc gagtcaggac 540
attaataact atcacagctg gtaccagcag aaacctggcc aggctcccag gctcctcatc 600
tatcgtgcaa acagattggt cgatggggtc ccagacaggt tcagtggcag cgggtatgga 660
acagatttta ccctcacaat taataacata gaatctgagg atgctgcata ttacttctgt 720
ctgaaatata atgtgtttcc gtacacgttc ggccaaggga ccaaggtgga gatcaaa    777

<210> 57
<211> 259
<212> PRT
<213> Artificial Sequence

<220> 
<223> EphA2 (2A4) scFv

<400> 57
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Leu Glu Ser Gly Gly Gly
            20                  25                  30          
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
        35                  40                  45              
Phe Thr Phe Ser Ser Tyr Thr Met Ser Trp Val Arg Gln Ala Pro Gly
    50                  55                  60                  
Gln Ala Leu Glu Trp Met Gly Thr Ile Ser Ser Arg Gly Thr Tyr Thr
65                  70                  75                  80  
Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
                85                  90                  95      
Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
            100                 105                 110         
Thr Ala Val Tyr Tyr Cys Ala Arg Glu Ala Ile Phe Thr His Trp Gly
        115                 120                 125             
Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
    130                 135                 140                 
Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro
145                 150                 155                 160 
Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys
                165                 170                 175     
Ala Ser Gln Asp Ile Asn Asn Tyr His Ser Trp Tyr Gln Gln Lys Pro
            180                 185                 190         
Gly Gln Ala Pro Arg Leu Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp
        195                 200                 205             
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Tyr Gly Thr Asp Phe Thr
    210                 215                 220                 
Leu Thr Ile Asn Asn Ile Glu Ser Glu Asp Ala Ala Tyr Tyr Phe Cys
225                 230                 235                 240 
Leu Lys Tyr Asn Val Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val
                245                 250                 255     
Glu Ile Lys
            


<210> 58
<211> 777
<212> DNA
<213> Unknown

<220> 
<223> EpHA2 (4H5) scFv

<400> 58
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atcccacagg tgcagctgtt ggagtctggg ggaggcttgg tacagcctgg ggggtccctg 120
agactctcct gtgcagcctc tggattcacc tttagcagct ataccatgtc ttgggtgcga 180
caggcccctg gacaagcgct tgagtggatg ggaaccatta gtagtggtgg tacttacacc 240
tactatccag acagtgtgaa gggccgattc accatctcca gagacaacgc caagaactca 300
ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ctgtgtatta ctgtgcgaga 360
gaagctatct ttacttactg gggccgtggc accctggtca ccgtctcctc aggtggtggt 420
ggttctggcg gcggcggctc cggtggtggt ggttctgaca tccagttgac ccagtctcca 480
tcctccctgt ctgcatctgt aggagacaga gtcaccatca cttgcaaggc gagtcaggac 540
attaataact atttaagctg gtaccagcag aaacctggcc aggctcccag gctcctcatc 600
tatcgtgcaa acagattggt agatggggtc ccagacaggt tcagtggcag cgggtatgga 660
acagatttta ccctcacaat taataacata gaatctgagg atgctgcata ttacttctgt 720
ctgaaatatg atgtgtttcc gtacacgttc ggccaaggga ccaaggtgga gatcaaa    777

<210> 59
<211> 259
<212> PRT
<213> Artificial Sequence

<220> 
<223> EpHA2 (4H5) scFv

<400> 59
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Leu Glu Ser Gly Gly Gly
            20                  25                  30          
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
        35                  40                  45              
Phe Thr Phe Ser Ser Tyr Thr Met Ser Trp Val Arg Gln Ala Pro Gly
    50                  55                  60                  
Gln Ala Leu Glu Trp Met Gly Thr Ile Ser Ser Gly Gly Thr Tyr Thr
65                  70                  75                  80  
Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
                85                  90                  95      
Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
            100                 105                 110         
Thr Ala Val Tyr Tyr Cys Ala Arg Glu Ala Ile Phe Thr Tyr Trp Gly
        115                 120                 125             
Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
    130                 135                 140                 
Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro
145                 150                 155                 160 
Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys
                165                 170                 175     
Ala Ser Gln Asp Ile Asn Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro
            180                 185                 190         
Gly Gln Ala Pro Arg Leu Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp
        195                 200                 205             
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Tyr Gly Thr Asp Phe Thr
    210                 215                 220                 
Leu Thr Ile Asn Asn Ile Glu Ser Glu Asp Ala Ala Tyr Tyr Phe Cys
225                 230                 235                 240 
Leu Lys Tyr Asp Val Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val
                245                 250                 255     
Glu Ile Lys
            


<210> 60
<211> 819
<212> DNA
<213> Unknown

<220> 
<223> FITC (E2) scFv

<400> 60
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atcccaagcg tgctgacaca gcctagctcc gtgtctgccg cccctggcca gaaagtgacc 120
atcagctgta gcggcagcac cagcaacatc ggcaacaact acgtgtcctg gtatcagcag 180
caccccggca aggcccccaa gctgatgatc tacgacgtgt ccaagcggcc cagcggcgtg 240
cccgatagat tttccggcag caagagcggc aacagcgcca gcctggatat cagcggcctg 300
cagtctgagg acgaggccga ctactattgc gccgcctggg acgatagcct gagcgagttc 360
ctgtttggca ccggcaccaa gctgacagtg ctgggcggag gcggaggatc tggcggcgga 420
ggaagtggcg gagggggatc tcaggtgcag ctggtggaaa gcggcggcaa cctggtgcag 480
cctggcggat ctctgagact gagctgtgcc gccagcggct tcaccttcgg cagcttcagc 540
atgagctggg tgcgccaggc tcctggggga ggactggaat gggtggcagg actgagcgcc 600
agaagcagcc tgacccacta cgccgatagc gtgaagggcc ggttcaccat cagccgggac 660
aacgccaaga acagcgtgta cctgcagatg aacagcctgc gggtggaaga taccgccgtg 720
tactactgcg ccagacggtc ctacgacagc agcggctact ggggccactt ctacagctac 780
atggacgtgt ggggccaggg caccctcgtg acagtgtct                        819

<210> 61
<211> 273
<212> PRT
<213> Artificial Sequence

<220> 
<223> FITC (E2) scFv

<400> 61
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Ser Val Leu Thr Gln Pro Ser Ser Val Ser
            20                  25                  30          
Ala Ala Pro Gly Gln Lys Val Thr Ile Ser Cys Ser Gly Ser Thr Ser
        35                  40                  45              
Asn Ile Gly Asn Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys
    50                  55                  60                  
Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val
65                  70                  75                  80  
Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Ser Ala Ser Leu Asp
                85                  90                  95      
Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala
            100                 105                 110         
Trp Asp Asp Ser Leu Ser Glu Phe Leu Phe Gly Thr Gly Thr Lys Leu
        115                 120                 125             
Thr Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
    130                 135                 140                 
Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Asn Leu Val Gln
145                 150                 155                 160 
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe
                165                 170                 175     
Gly Ser Phe Ser Met Ser Trp Val Arg Gln Ala Pro Gly Gly Gly Leu
            180                 185                 190         
Glu Trp Val Ala Gly Leu Ser Ala Arg Ser Ser Leu Thr His Tyr Ala
        195                 200                 205             
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn
    210                 215                 220                 
Ser Val Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val
225                 230                 235                 240 
Tyr Tyr Cys Ala Arg Arg Ser Tyr Asp Ser Ser Gly Tyr Trp Gly His
                245                 250                 255     
Phe Tyr Ser Tyr Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val
            260                 265                 270         
Ser
    


<210> 62
<211> 381
<212> DNA
<213> Unknown

<220> 
<223> GD2 (hu3F8) scFv

<400> 62
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atcccaagca tcgtgatgac ccagaccccc aagttcctgc tggtgagcgc cggcgacagg 120
gtgaccatca cctgcaaggc cagccagagc gtgagcaacg acgtgacctg gtaccagcag 180
aaggccggcc agagccccaa gctgctgatc tacagcgcca gcaacaggta cagcggcgtg 240
cccgacaggt tcaccggcag cggctacggc accgccttca ccttcaccat cagcaccgtg 300
caggccgagg acctggccgt gtacttctgc cagcaggact acagcagctt cggcggcggc 360
accaagctgg agatcaagag g                                           381

<210> 63
<211> 127
<212> PRT
<213> Artificial Sequence

<220> 
<223> GD2 (hu3F8) scFv

<400> 63
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Ser Ile Val Met Thr Gln Thr Pro Lys Phe
            20                  25                  30          
Leu Leu Val Ser Ala Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser
        35                  40                  45              
Gln Ser Val Ser Asn Asp Val Thr Trp Tyr Gln Gln Lys Ala Gly Gln
    50                  55                  60                  
Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Asn Arg Tyr Ser Gly Val
65                  70                  75                  80  
Pro Asp Arg Phe Thr Gly Ser Gly Tyr Gly Thr Ala Phe Thr Phe Thr
                85                  90                  95      
Ile Ser Thr Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln
            100                 105                 110         
Asp Tyr Ser Ser Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
        115                 120                 125         


<210> 64
<211> 801
<212> DNA
<213> Unknown

<220> 
<223> Her2 (Herceptin) scFv

<400> 64
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atcccagata tccagatgac ccagtccccg agctccctgt ccgcctctgt gggcgatagg 120
gtcaccatca cctgccgtgc cagtcaggat gtgaatactg ctgtagcctg gtatcaacag 180
aaaccaggaa aagctccgaa actactgatt tactcggcat ccttcctcta ctctggagtc 240
ccttctcgct tctctggttc cagatctggg acggatttca ctctgaccat cagcagtctg 300
cagccggaag acttcgcaac ttattactgt cagcaacatt atactactcc tcccacgttc 360
ggacagggta ccaaggtgga gatcaaaggc agtactagcg gcggtggctc cgggggcgga 420
tccggtgggg gcggcagcag cgaggttcag ctggtggagt ctggcggtgg cctggtgcag 480
ccagggggct cactccgttt gtcctgtgca gcttctggct tcaacattaa agacacctat 540
atacactggg tgcgtcaggc cccgggtaag ggcctggaat gggttgcaag gatttatcct 600
acgaatggtt atactagata tgccgatagc gtcaagggcc gtttcactat aagcgcagac 660
acatccaaaa acacagccta cctgcagatg aacagcctgc gtgctgagga cactgccgtc 720
tattattgtt ctagatgggg aggggacggc ttctatgcta tggactactg gggtcaagga 780
accctggtca ccgtctcgag t                                           801

<210> 65
<211> 267
<212> PRT
<213> Artificial Sequence

<220> 
<223> Her2 (Herceptin) scFv

<400> 65
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
            20                  25                  30          
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
        35                  40                  45              
Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys
    50                  55                  60                  
Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr
                85                  90                  95      
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
            100                 105                 110         
His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
        115                 120                 125             
Lys Gly Ser Thr Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly
    130                 135                 140                 
Gly Ser Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln
145                 150                 155                 160 
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile
                165                 170                 175     
Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
            180                 185                 190         
Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala
        195                 200                 205             
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn
    210                 215                 220                 
Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
225                 230                 235                 240 
Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr
                245                 250                 255     
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
            260                 265         


<210> 66
<211> 722
<212> DNA
<213> Unknown

<220> 
<223> IL13R2a (hu08) VlVh scFv

<400> 66
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atcccagaca tccagatgac ccagtccccc tcttctctgt ctgcctctgt gggcgacaga 120
gtgaccatca cctgtaaggc cagtcaggat gtaggtactg ctgtagcctg gtatcagcag 180
aagcctggca aggctcccaa gctgctgatc tactcggcat cctaccggtc cactggcgtg 240
ccttccagat tctccggctc tggctctggc accgatttca ccctgaccat ctcctccctc 300
cagcctgagg atttcgccac ctactactgc cagcaccatt atagtgctcc gtggacgttt 360
ggcggcggaa caaaggtgga gatcaagggt ggtggtggtt ctggcggcgg cggctccggt 420
ggtggtggtt ctgaggtgca gctggtggag tctggcggcg gactggtgca gcctggcggc 480
tctctgagac tgtcttgtgc cgcctccggc ttcaccttca gtaggaatgg catgtcttgg 540
gtgaggcagg cccctggcaa gggcctggag tgggtggcca ccgttagtag tggtggtagt 600
tacatctact atgcagacag tgtgaagggg cggttcacca tctccaggga caacgccaag 660
aactccctgt acctccagat gaactccctg agggccgagg ataccgccgt gtactactgt 720
gc                                                                722

<210> 67
<211> 240
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL13RA2 (HU08) VlVh scFv

<400> 67
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
            20                  25                  30          
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser
        35                  40                  45              
Gln Asp Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys
    50                  55                  60                  
Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Ser Thr Gly Val
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
                85                  90                  95      
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His
            100                 105                 110         
His Tyr Ser Ala Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile
        115                 120                 125             
Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
    130                 135                 140                 
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
145                 150                 155                 160 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Asn
                165                 170                 175     
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
            180                 185                 190         
Ala Thr Val Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Ala Asp Ser Val
        195                 200                 205             
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
    210                 215                 220                 
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
225                 230                 235                 240 


<210> 68
<211> 809
<212> DNA
<213> Unknown

<220> 
<223> IL13RA2 (HU08) VlVh scFv

<400> 68
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atcccagagg tgcagctggt ggagtctggc ggcggactgg tgcagcctgg cggctctctg 120
agactgtctt gtgccgcctc cggcttcacc ttcagtagga atggcatgtc ttgggtgagg 180
caggcccctg gcaagggcct ggagtgggtg gccaccgtta gtagtggtgg tagttacatc 240
tactatgcag acagtgtgaa ggggcggttc accatctcca gggacaacgc caagaactcc 300
ctgtacctcc agatgaactc cctgagggcc gaggataccg ccgtgtacta ctgtgccaga 360
caagggacta cggcactagc tacgaggttc ttcgatgtct ggggccaggg caccctggtg 420
accgtgtcct ctggtggtgg tggttctggc ggcggcggct ccggtggtgg tggttctgac 480
atccagatga cccagtcccc ctcttctctg tctgcctctg tgggcgacag agtgaccatc 540
acctgtaagg ccagtcagga tgtaggtact gctgtagcct ggtatcagca gaagcctggc 600
aaggctccca agctgctgat ctactcggca tcctaccggt ccactggcgt gccttccaga 660
ttctccggct ctggctctgg caccgatttc accctgacca tctcctccct ccagcctgag 720
gatttcgcca cctactactg ccagcaccat tatagtgctc cgtggacgtt tggcggcgga 780
acaaaggtgg agatcaagga atctaagta                                   809

<210> 69
<211> 269
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL13RA2 (HU08) VlVh scFv

<400> 69
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly
            20                  25                  30          
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
        35                  40                  45              
Phe Thr Phe Ser Arg Asn Gly Met Ser Trp Val Arg Gln Ala Pro Gly
    50                  55                  60                  
Lys Gly Leu Glu Trp Val Ala Thr Val Ser Ser Gly Gly Ser Tyr Ile
65                  70                  75                  80  
Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
                85                  90                  95      
Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
            100                 105                 110         
Thr Ala Val Tyr Tyr Cys Ala Arg Gln Gly Thr Thr Ala Leu Ala Thr
        115                 120                 125             
Arg Phe Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
    130                 135                 140                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp
145                 150                 155                 160 
Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp
                165                 170                 175     
Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala Val
            180                 185                 190         
Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
        195                 200                 205             
Ser Ala Ser Tyr Arg Ser Thr Gly Val Pro Ser Arg Phe Ser Gly Ser
    210                 215                 220                 
Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu
225                 230                 235                 240 
Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Ser Ala Pro Trp Thr
                245                 250                 255     
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Glu Ser Lys
            260                 265                 


<210> 70
<211> 794
<212> DNA
<213> Unknown

<220> 
<223> IL13RA2 (HU07) VlVh scFv

<400> 70
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atcccagata ttcagatgac ccagagcccg agcagcctga gcgcgagcgt gggcgatcgc 120
gtgaccatta cctgcaccgc gagcctgagc gtgagcagca cctatctgca ttggtatcag 180
cagaaaccgg gcaaagcgcc gaaactgctg atttatagca ccagcaacct ggcgagcggc 240
gtgccgagcc gctttagcgg cagcggcagc ggcaccgatt ttaccctgac cattagcagc 300
ctgcagccgg aagattttgc gacctattat tgccatcagt atcatcgcag cccgctgacc 360
tttggcggcg gcaccaaagt ggaaattaaa ggtggtggtg gttctggcgg cggcggctcc 420
ggtggtggtg gttctgaagt gcagctggtg gaaagcggcg gcggcctggt gcagccgggc 480
ggcagcctgc gcctgagctg cgcggcgagc ggctttacct ttaccaaata tggcgtgcat 540
tgggtgcgcc aggcgccggg caaaggcctg gaatgggtgg cggtgaaatg ggcgggcggc 600
agcaccgatt ataacagcgc gctgatgagc cgctttacca ttagccgcga taacgcgaaa 660
aacagcctgt atctgcagat gaacagcctg cgcgcggaag ataccgcggt gtattattgc 720
gcgcgcgatc atcgcgatgc gatggattat tggggccagg gcaccctggt gaccgtgagc 780
agcgaatcta agta                                                   794

<210> 71
<211> 264
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL13RA2 (HU07) VlVh scFv

<400> 71
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
            20                  25                  30          
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Thr Ala Ser
        35                  40                  45              
Leu Ser Val Ser Ser Thr Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly
    50                  55                  60                  
Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly
65                  70                  75                  80  
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
                85                  90                  95      
Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His
            100                 105                 110         
Gln Tyr His Arg Ser Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu
        115                 120                 125             
Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
    130                 135                 140                 
Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
145                 150                 155                 160 
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Lys
                165                 170                 175     
Tyr Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
            180                 185                 190         
Val Ala Val Lys Trp Ala Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu
        195                 200                 205             
Met Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
    210                 215                 220                 
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
225                 230                 235                 240 
Ala Arg Asp His Arg Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu
                245                 250                 255     
Val Thr Val Ser Ser Glu Ser Lys
            260                 


<210> 72
<211> 794
<212> DNA
<213> Unknown

<220> 
<223> IL13RA2 (HU07) VlVh scFv

<400> 72
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atcccagaag tgcagctggt ggaaagcggc ggcggcctgg tgcagccggg cggcagcctg 120
cgcctgagct gcgcggcgag cggctttacc tttaccaaat atggcgtgca ttgggtgcgc 180
caggcgccgg gcaaaggcct ggaatgggtg gcggtgaaat gggcgggcgg cagcaccgat 240
tataacagcg cgctgatgag ccgctttacc attagccgcg ataacgcgaa aaacagcctg 300
tatctgcaga tgaacagcct gcgcgcggaa gataccgcgg tgtattattg cgcgcgcgat 360
catcgcgatg cgatggatta ttggggccag ggcaccctgg tgaccgtgag cagcggtggt 420
ggtggttctg gcggcggcgg ctccggtggt ggtggttctg atattcagat gacccagagc 480
ccgagcagcc tgagcgcgag cgtgggcgat cgcgtgacca ttacctgcac cgcgagcctg 540
agcgtgagca gcacctatct gcattggtat cagcagaaac cgggcaaagc gccgaaactg 600
ctgatttata gcaccagcaa cctggcgagc ggcgtgccga gccgctttag cggcagcggc 660
agcggcaccg attttaccct gaccattagc agcctgcagc cggaagattt tgcgacctat 720
tattgccatc agtatcatcg cagcccgctg acctttggcg gcggcaccaa agtggaaatt 780
aaagaatcta agta                                                   794

<210> 73
<211> 264
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL13RA2 (HU07) VlVh

<400> 73
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly
            20                  25                  30          
Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly
        35                  40                  45              
Phe Thr Phe Thr Lys Tyr Gly Val His Trp Val Arg Gln Ala Pro Gly
    50                  55                  60                  
Lys Gly Leu Glu Trp Val Ala Val Lys Trp Ala Gly Gly Ser Thr Asp
65                  70                  75                  80  
Tyr Asn Ser Ala Leu Met Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala
                85                  90                  95      
Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
            100                 105                 110         
Ala Val Tyr Tyr Cys Ala Arg Asp His Arg Asp Ala Met Asp Tyr Trp
        115                 120                 125             
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly
    130                 135                 140                 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser
145                 150                 155                 160 
Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys
                165                 170                 175     
Thr Ala Ser Leu Ser Val Ser Ser Thr Tyr Leu His Trp Tyr Gln Gln
            180                 185                 190         
Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Thr Ser Asn Leu
        195                 200                 205             
Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
    210                 215                 220                 
Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
225                 230                 235                 240 
Tyr Cys His Gln Tyr His Arg Ser Pro Leu Thr Phe Gly Gly Gly Thr
                245                 250                 255     
Lys Val Glu Ile Lys Glu Ser Lys
            260                 


<210> 74
<211> 401
<212> DNA
<213> Unknown

<220> 
<223> Anti-IL13RA2 (IL13 ZETAKINE)

<400> 74
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atcccaggcc ctgtgcctcc ctctacagcc ctcaggtacc tcattgagga gctggtcaac 120
atcacccaga accagaaggc tccgctctgc aatggcagca tggtatggag catcaacctg 180
acagctggca tgtactgtgc agccctggaa tccctgatca acgtgtcagg ctgcagtgcc 240
atcgagaaga cccagaggat gctgagcgga ttctgcccgc acaaggtctc agctgggcag 300
ttttccagct tgcatgtccg agacaccaaa atcgaggtgg cccagtttgt aaaggacctg 360
ctcttacatt taaagaaact ttttcgcgag ggacggttca a                     401

<210> 75
<211> 133
<212> PRT
<213> Artificial Sequence

<220> 
<223> Anti-IL13RA2 (IL13 ZETAKINE) A

<400> 75
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg
            20                  25                  30          
Tyr Leu Ile Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro
        35                  40                  45              
Leu Cys Asn Gly Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met
    50                  55                  60                  
Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala
65                  70                  75                  80  
Ile Glu Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val
                85                  90                  95      
Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu
            100                 105                 110         
Val Ala Gln Phe Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe
        115                 120                 125             
Arg Glu Gly Arg Phe
    130             


<210> 76
<211> 807
<212> DNA
<213> Unknown

<220> 
<223> OAGD2 (8B6) VLVH SCFV NUCLEOTIDE SEQUENCE

<400> 76
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atcccagatg ttgtgatgac ccaaactcca ctctccctgc ctgtcagtct tggagatcaa 120
gcctcaatct cttgcagatc tagtcagagc cttctaaaaa ataatggaaa caccttttta 180
cattggtacc tgcagaagtc aggccagtct ccaaagctcc ttatctacaa agtttccaac 240
cgactttctg gggtcccaga caggttcagt ggcagtggat cagggacata tttcacactc 300
aagatcagca gagtggaggc tgaggatctg ggagtttatt tctgctctca aagtacacat 360
attccgtaca cattcggagg ggggaccaag ctcgagctga aacgaggcgg agggggctct 420
ggcggcggag gatctggggg agggggcagc gaggtgaaac tggtggagtc tggaggaggc 480
ttggtgctgc ctggggattc tctgagactc tcctgtgcaa cttctgagtt caccttcact 540
gattactaca tgacttgggt ccgccagcct ccaagaaagg cacttgagtg gttgggtttt 600
attagaaaca gagctaatgg ttacacaaca gagtacaatc catctgtgaa gggtcggttc 660
accatttcca gagataattc ccaaagcatc ctctatcttc aaatgaacac cctgagaact 720
gaggacagtg ccacttatta ctgtgcaaga gtctctaact gggcctttga ctactggggc 780
caaggcacca ctctcacagt ctcctca                                     807

<210> 77
<211> 269
<212> PRT
<213> Artificial Sequence

<220> 
<223> OAGD2 (8B6) VlVh scFv

<400> 77
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Asp Val Val Met Thr Gln Thr Pro Leu Ser
            20                  25                  30          
Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser
        35                  40                  45              
Gln Ser Leu Leu Lys Asn Asn Gly Asn Thr Phe Leu His Trp Tyr Leu
    50                  55                  60                  
Gln Lys Ser Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn
65                  70                  75                  80  
Arg Leu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr
                85                  90                  95      
Tyr Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val
            100                 105                 110         
Tyr Phe Cys Ser Gln Ser Thr His Ile Pro Tyr Thr Phe Gly Gly Gly
        115                 120                 125             
Thr Lys Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Val Glu Ser Gly Gly Gly
145                 150                 155                 160 
Leu Val Leu Pro Gly Asp Ser Leu Arg Leu Ser Cys Ala Thr Ser Glu
                165                 170                 175     
Phe Thr Phe Thr Asp Tyr Tyr Met Thr Trp Val Arg Gln Pro Pro Arg
            180                 185                 190         
Lys Ala Leu Glu Trp Leu Gly Phe Ile Arg Asn Arg Ala Asn Gly Tyr
        195                 200                 205             
Thr Thr Glu Tyr Asn Pro Ser Val Lys Gly Arg Phe Thr Ile Ser Arg
    210                 215                 220                 
Asp Asn Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn Thr Leu Arg Thr
225                 230                 235                 240 
Glu Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Val Ser Asn Trp Ala Phe
                245                 250                 255     
Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser
            260                 265                 


<210> 78
<211> 810
<212> DNA
<213> Unknown

<220> 
<223> ROR1 (R12) scFv

<400> 78
atgctgctgc tggtgacaag cctgctgctg tgcgagctgc cccaccccgc ctttctgctg 60
atcccccagg aacagctcgt cgaaagcggc ggcagactgg tgacacctgg cggcagcctg 120
accctgagct gcaaggccag cggcttcgac ttcagcgcct actacatgag ctgggtccgc 180
caggcccctg gcaagggact ggaatggatc gccaccatct accccagcag cggcaagacc 240
tactacgcca cctgggtgaa cggacggttc accatctcca gcgacaacgc ccagaacacc 300
gtggacctgc agatgaacag cctgacagcc gccgaccggg ccacctactt ttgcgccaga 360
gacagctacg ccgacgacgg cgccctgttc aacatctggg gccctggcac cctggtgaca 420
atctctagcg gcggaggcgg atctggtggc ggaggaagtg gcggcggagg atctgagctg 480
gtgctgaccc agagcccctc tgtgtctgct gccctgggaa gccctgccaa gatcacctgt 540
accctgagca gcgcccacaa gaccgacacc atcgactggt atcagcagct gcagggcgag 600
gcccccagat acctgatgca ggtgcagagc gacggcagct acaccaagag gccaggcgtg 660
cccgaccggt tcagcggatc tagctctggc gccgaccgct acctgatcat ccccagcgtg 720
caggccgatg acgaggccga ttactactgt ggcgccgact acatcggcgg ctacgtgttc 780
ggcggaggca cccagctgac cgtgaccggc                                  810

<210> 79
<211> 270
<212> PRT
<213> Artificial Sequence

<220> 
<223> ROR1 (R12) scFv

<400> 79
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Gln Glu Gln Leu Val Glu Ser Gly Gly Arg
            20                  25                  30          
Leu Val Thr Pro Gly Gly Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly
        35                  40                  45              
Phe Asp Phe Ser Ala Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly
    50                  55                  60                  
Lys Gly Leu Glu Trp Ile Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr
65                  70                  75                  80  
Tyr Tyr Ala Thr Trp Val Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn
                85                  90                  95      
Ala Gln Asn Thr Val Asp Leu Gln Met Asn Ser Leu Thr Ala Ala Asp
            100                 105                 110         
Arg Ala Thr Tyr Phe Cys Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala
        115                 120                 125             
Leu Phe Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Ile Ser Ser Gly
    130                 135                 140                 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu
145                 150                 155                 160 
Val Leu Thr Gln Ser Pro Ser Val Ser Ala Ala Leu Gly Ser Pro Ala
                165                 170                 175     
Lys Ile Thr Cys Thr Leu Ser Ser Ala His Lys Thr Asp Thr Ile Asp
            180                 185                 190         
Trp Tyr Gln Gln Leu Gln Gly Glu Ala Pro Arg Tyr Leu Met Gln Val
        195                 200                 205             
Gln Ser Asp Gly Ser Tyr Thr Lys Arg Pro Gly Val Pro Asp Arg Phe
    210                 215                 220                 
Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ile Ile Pro Ser Val
225                 230                 235                 240 
Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Tyr Ile Gly
                245                 250                 255     
Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly
            260                 265                 270 


<210> 80
<211> 417
<212> DNA
<213> Unknown

<220> 
<223> CD33 (H2H12) VlVh scFv

<400> 80
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atcccacagg ttcagctggt gcagtctgga gctgaggtga agaagcctgg ggcctcagtg 120
aaggtctcct gcaaggcttc tggttacacc tttaccaatt atgatataaa ttgggtgaga 180
caggcccctg gacaagggct tgagtggatt ggatggattt atcctggaga tggtagtacc 240
aaatataatg agaaattcaa ggccaaggct accctgacag ctgacacatc caccagcaca 300
gcctacatgg agctgaggag cctgagatct gatgacacag ctgtgtatta ctgtgcttct 360
ggatatgaag atgctatgga ctactggggg caagggacca cagtcacagt ctcctca    417

<210> 81
<211> 139
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD33 (H2H12) VlVh scFv

<400> 81
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Val Gln Ser Gly Ala Glu
            20                  25                  30          
Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly
        35                  40                  45              
Tyr Thr Phe Thr Asn Tyr Asp Ile Asn Trp Val Arg Gln Ala Pro Gly
    50                  55                  60                  
Gln Gly Leu Glu Trp Ile Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr
65                  70                  75                  80  
Lys Tyr Asn Glu Lys Phe Lys Ala Lys Ala Thr Leu Thr Ala Asp Thr
                85                  90                  95      
Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp
            100                 105                 110         
Thr Ala Val Tyr Tyr Cys Ala Ser Gly Tyr Glu Asp Ala Met Asp Tyr
        115                 120                 125             
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
    130                 135                 


<210> 82
<211> 387
<212> DNA
<213> Unknown

<220> 
<223> CD33 (H2H12) VlVh scFv

<400> 82
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atcccagaca tccagatgac ccagtctcca tcctcactgt ctgcatctgt aggagacaga 120
gtcaccatca attgtaaggc tagtcaggac attaatagct atttgagctg gtttcagcag 180
aaaccaggga aagcccctaa gaccctgatc tatagagcaa atagattggt agatggggtc 240
ccatcaaggt tctctggcag tggatctggg caagattata ctctcaccat cagcagcctg 300
cagcctgaag attttgcaac ttattactgc ttgcagtatg atgagtttcc tctcacattt 360
ggaggaggga ccaaggtgga gatcaaa                                     387

<210> 83
<211> 129
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD33 (H2H12) VlVh scFv

<400> 83
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser
            20                  25                  30          
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Asn Cys Lys Ala Ser
        35                  40                  45              
Gln Asp Ile Asn Ser Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys
    50                  55                  60                  
Ala Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Thr Leu Thr
                85                  90                  95      
Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln
            100                 105                 110         
Tyr Asp Glu Phe Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile
        115                 120                 125             
Lys
    


<210> 84
<211> 450
<212> DNA
<213> Unknown

<220> 
<223> MESOTHELIN (P4) scFv

<400> 84
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atcccacagg tacagctgca gcagtcaggt ccaggactcg tgacgccctc gcagaccctc 120
tcactcacct gtgccatctc cggggacagt gtctctagca acagtgctac ttggaactgg 180
atcaggcagt ccccatcgag aggccttgag tggctgggaa ggacatacta caggtccaag 240
tggtataacg actatgcagt atctgtgaaa agtcgaatga gcatcaaccc agacacatcc 300
aagaaccagt tctccctgca gctgaactct gtgactcccg aggacacggc tgtgtattac 360
tgtgcaagag gaatgatgac ttactattac ggtatggacg tctggggcca agggaccacg 420
gtcaccgtct cctcaggaat tctaggatcc                                  450

<210> 85
<211> 150
<212> PRT
<213> Artificial Sequence

<220> 
<223> MESOTHELIN (P4) scFv

<400> 85
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Ser Gly Pro Gly
            20                  25                  30          
Leu Val Thr Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly
        35                  40                  45              
Asp Ser Val Ser Ser Asn Ser Ala Thr Trp Asn Trp Ile Arg Gln Ser
    50                  55                  60                  
Pro Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys
65                  70                  75                  80  
Trp Tyr Asn Asp Tyr Ala Val Ser Val Lys Ser Arg Met Ser Ile Asn
                85                  90                  95      
Pro Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr
            100                 105                 110         
Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met Met Thr Tyr
        115                 120                 125             
Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser
    130                 135                 140                 
Ser Gly Ile Leu Gly Ser
145                 150 


<210> 86
<211> 1344
<212> DNA
<213> Unknown

<220> 
<223> VAR2CSA (ID1-DBL2XB) scFv

<400> 86
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atcccaagtc tcacgaatgg gtataagtgc gacaaatgca aatcaggcac atcccggtcc 120
aaaaaaaaat ggatctggaa aaagagcagc gggaatgagg agggcctgca ggaagaatac 180
gctaacacaa tcggactgcc ccctcgaact caatctctgt accttgggaa cttgcctaaa 240
ctggaaaacg tctgtgaaga cgtcaaggac ataaacttcg atacgaaaga gaagttcctg 300
gctggatgcc ttatcgtgag ctttcacgag ggaaagaatc tgaagaaaag gtacccacag 360
aataaaaact ctggcaataa agagaatttg tgcaaggccc tggagtactc ttttgcggac 420
tatggcgatc tcataaaggg cacaagcatc tgggataatg agtataccaa ggatctggag 480
ctgaatctgc agaataactt tgggaaattg tttgggaagt atattaaaaa aaataatacc 540
gccgagcagg acacatccta ctcttccctc gacgagctgc gggagtcatg gtggaacacc 600
aacaaaaagt atatctggac ggcaatgaaa catggcgcgg aaatgaatat caccacttgt 660
aatgcagacg gctctgtcac cgggtccggt tcttcttgcg atgatatacc aaccatcgat 720
ttgattccgc agtatctgag atttctccaa gagtgggtgg aaaatttttg cgagcagagg 780
caagctaagg tcaaggacgt gatcaccaat tgtaaaagtt gcaaagaatc agggaacaag 840
tgcaaaaccg agtgtaagac gaagtgcaag gacgaatgcg agaaatataa aaaattcatc 900
gaggcttgtg gaacagccgg gggtgggatt gggaccgcag gcagcccatg gagcaagcgg 960
tgggaccaaa tctataaacg atacagcaag cacatcgaag atgccaagcg gaaccgcaaa 1020
gctggcacaa aaaactgtgg gactagcagc acgactaatg ccgcggcaag cactgatgaa 1080
aataaatgcg tgcaaagtga catcgactct ttcttcaaac acctgatcga tatcggtctt 1140
actacgccaa gcagctacct cagtaatgtt ctggatgata atatttgtgg ggcggacaaa 1200
gcaccttgga ctacctacac cacctatacc acaacagaga agtgtaataa agagagagac 1260
aaatcaaagt ctcagagctc tgatacactg gtcgttgtga atgtgccaag ccctttgggg 1320
aatacgccct acagatataa atac                                        1344

<210> 87
<211> 448
<212> PRT
<213> Artificial Sequence

<220> 
<223> VAR2CSA (ID1-DBL2XB) scFv

<400> 87
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Ser Leu Thr Asn Gly Tyr Lys Cys Asp Lys
            20                  25                  30          
Cys Lys Ser Gly Thr Ser Arg Ser Lys Lys Lys Trp Ile Trp Lys Lys
        35                  40                  45              
Ser Ser Gly Asn Glu Glu Gly Leu Gln Glu Glu Tyr Ala Asn Thr Ile
    50                  55                  60                  
Gly Leu Pro Pro Arg Thr Gln Ser Leu Tyr Leu Gly Asn Leu Pro Lys
65                  70                  75                  80  
Leu Glu Asn Val Cys Glu Asp Val Lys Asp Ile Asn Phe Asp Thr Lys
                85                  90                  95      
Glu Lys Phe Leu Ala Gly Cys Leu Ile Val Ser Phe His Glu Gly Lys
            100                 105                 110         
Asn Leu Lys Lys Arg Tyr Pro Gln Asn Lys Asn Ser Gly Asn Lys Glu
        115                 120                 125             
Asn Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu
    130                 135                 140                 
Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu
145                 150                 155                 160 
Leu Asn Leu Gln Asn Asn Phe Gly Lys Leu Phe Gly Lys Tyr Ile Lys
                165                 170                 175     
Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp Glu
            180                 185                 190         
Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Thr Ala
        195                 200                 205             
Met Lys His Gly Ala Glu Met Asn Ile Thr Thr Cys Asn Ala Asp Gly
    210                 215                 220                 
Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile Asp
225                 230                 235                 240 
Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu Asn Phe
                245                 250                 255     
Cys Glu Gln Arg Gln Ala Lys Val Lys Asp Val Ile Thr Asn Cys Lys
            260                 265                 270         
Ser Cys Lys Glu Ser Gly Asn Lys Cys Lys Thr Glu Cys Lys Thr Lys
        275                 280                 285             
Cys Lys Asp Glu Cys Glu Lys Tyr Lys Lys Phe Ile Glu Ala Cys Gly
    290                 295                 300                 
Thr Ala Gly Gly Gly Ile Gly Thr Ala Gly Ser Pro Trp Ser Lys Arg
305                 310                 315                 320 
Trp Asp Gln Ile Tyr Lys Arg Tyr Ser Lys His Ile Glu Asp Ala Lys
                325                 330                 335     
Arg Asn Arg Lys Ala Gly Thr Lys Asn Cys Gly Thr Ser Ser Thr Thr
            340                 345                 350         
Asn Ala Ala Ala Ser Thr Asp Glu Asn Lys Cys Val Gln Ser Asp Ile
        355                 360                 365             
Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser
    370                 375                 380                 
Ser Tyr Leu Ser Asn Val Leu Asp Asp Asn Ile Cys Gly Ala Asp Lys
385                 390                 395                 400 
Ala Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr Thr Glu Lys Cys Asn
                405                 410                 415     
Lys Glu Arg Asp Lys Ser Lys Ser Gln Ser Ser Asp Thr Leu Val Val
            420                 425                 430         
Val Asn Val Pro Ser Pro Leu Gly Asn Thr Pro Tyr Arg Tyr Lys Tyr
        435                 440                 445             


<210> 88
<211> 2202
<212> DNA
<213> Unknown

<220> 
<223> CCR(CD122)

<400> 88
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atcccagatt gtgatattga aggtaaagat ggcaaacaat atgagagtgt tctaatggtc 120
agcatcgatc aattattgga cagcatgaaa gaaattggta gcaattgcct gaataatgaa 180
tttaactttt ttaaaagaca tatctgtgat gctaataagg aaggtatgtt tttattccgt 240
gctgctcgca agttgaggca atttcttaaa atgaatagca ctggtgattt tgatctccac 300
ttattaaaag tttcagaagg cacaacaata ctgttgaact gcactggcca ggttaaagga 360
agaaaaccag ctgccctggg tgaagcccaa ccaacaaaga gtttggaaga aaataaatct 420
ttaaaggaac agaaaaaact gaatgacttg tgtttcctaa agagactatt acaagagata 480
aaaacttgtt ggaataaaat tttgatgggc actaaagaac acggaggcgg tgggagcgga 540
ggcggtggga gcatgacaat tctaggtaca acttttggca tggttttttc tttacttcaa 600
gtcgtttctg gagaaagtgg ctatgctcaa aatggagact tggaagatgc agaactggat 660
gactactcat tctcatgcta tagccagttg gaagtgaatg gatcgcagca ctcactgacc 720
tgtgcttttg aggacccaga tgtcaacatc accaatctgg aatttgaaat atgtggggcc 780
ctcgtggagg taaagtgcct gaatttcagg aaactacaag agatatattt catcgagaca 840
aagaaattct tactgattgg aaagagcaat atatgtgtga aggttggaga aaagagtcta 900
acctgcaaaa aaatagacct aaccactata gttaaacctg aggctccttt tgacctgagt 960
gtcatctatc gggaaggagc caatgacttt gtggtgacat ttaatacatc acacttgcaa 1020
aagaagtatg taaaagtttt aatgcacgat gtagcttacc gccaggaaaa ggatgaaaac 1080
aaatggacgc atgtgaattt atccagcaca aaactgacac tcctgcagag aaagctccaa 1140
ccggcagcaa tgtatgagat taaagttcga tccatccctg atcactattt taaaggcttc 1200
tggagtgaat ggagtccaag ttattacttc agaactccag agatcaataa tagctcaggg 1260
gagatggatc ctatcttact aaccatcagc attttgagtt ttttctctgt cgctctgttg 1320
gtcatcttgg cctgtgtgtt atggaactgc aggaacaccg ggccatggct gaagaaggtc 1380
ctgaagtgta acaccccaga cccctcgaag ttcttttccc agctgagctc agagcatgga 1440
ggagacgtcc agaagtggct ctcttcgccc ttcccctcat cgtccttcag ccctggcggc 1500
ctggcacctg agatctcgcc actagaagtg ctggagaggg acaaggtgac gcagctgctc 1560
ctgcagcagg acaaggtgcc tgagcccgca tccttaagca gcaaccactc gctgaccagc 1620
tgcttcacca accagggtta cttcttcttc cacctcccgg atgccttgga gatagaggcc 1680
tgccaggtgt actttactta cgacccctac tcagaggaag accctgatga gggtgtggcc 1740
ggggcaccca cagggtcttc cccccaaccc ctgcagcctc tgtcagggga ggacgacgcc 1800
tactgcacct tcccctccag ggatgacctg ctgctcttct cccccagtct cctcggtggc 1860
cccagccccc caagcactgc ccctgggggc agtggggccg gtgaagagag gatgccccct 1920
tctttgcaag aaagagtccc cagagactgg gacccccagc ccctggggcc tcccacccca 1980
ggagtcccag acctggtgga ttttcagcca ccccctgagc tggtgctgcg agaggctggg 2040
gaggaggtcc ctgacgctgg ccccagggag ggagtcagtt tcccctggtc caggcctcct 2100
gggcaggggg agttcagggc ccttaatgct cgcctgcccc tgaacactga tgcctacttg 2160
tccctccaag aactccaggg tcaggaccca actcacttgg tg                    2202

<210> 89
<211> 734
<212> PRT
<213> Artificial Sequence

<220> 
<223> CCR(CD122)

<400> 89
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys
            20                  25                  30          
Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser
        35                  40                  45              
Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe
    50                  55                  60                  
Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg
65                  70                  75                  80  
Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp
                85                  90                  95      
Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu
            100                 105                 110         
Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu
        115                 120                 125             
Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln
    130                 135                 140                 
Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile
145                 150                 155                 160 
Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Gly Gly
                165                 170                 175     
Gly Gly Ser Gly Gly Gly Gly Ser Met Thr Ile Leu Gly Thr Thr Phe
            180                 185                 190         
Gly Met Val Phe Ser Leu Leu Gln Val Val Ser Gly Glu Ser Gly Tyr
        195                 200                 205             
Ala Gln Asn Gly Asp Leu Glu Asp Ala Glu Leu Asp Asp Tyr Ser Phe
    210                 215                 220                 
Ser Cys Tyr Ser Gln Leu Glu Val Asn Gly Ser Gln His Ser Leu Thr
225                 230                 235                 240 
Cys Ala Phe Glu Asp Pro Asp Val Asn Ile Thr Asn Leu Glu Phe Glu
                245                 250                 255     
Ile Cys Gly Ala Leu Val Glu Val Lys Cys Leu Asn Phe Arg Lys Leu
            260                 265                 270         
Gln Glu Ile Tyr Phe Ile Glu Thr Lys Lys Phe Leu Leu Ile Gly Lys
        275                 280                 285             
Ser Asn Ile Cys Val Lys Val Gly Glu Lys Ser Leu Thr Cys Lys Lys
    290                 295                 300                 
Ile Asp Leu Thr Thr Ile Val Lys Pro Glu Ala Pro Phe Asp Leu Ser
305                 310                 315                 320 
Val Ile Tyr Arg Glu Gly Ala Asn Asp Phe Val Val Thr Phe Asn Thr
                325                 330                 335     
Ser His Leu Gln Lys Lys Tyr Val Lys Val Leu Met His Asp Val Ala
            340                 345                 350         
Tyr Arg Gln Glu Lys Asp Glu Asn Lys Trp Thr His Val Asn Leu Ser
        355                 360                 365             
Ser Thr Lys Leu Thr Leu Leu Gln Arg Lys Leu Gln Pro Ala Ala Met
    370                 375                 380                 
Tyr Glu Ile Lys Val Arg Ser Ile Pro Asp His Tyr Phe Lys Gly Phe
385                 390                 395                 400 
Trp Ser Glu Trp Ser Pro Ser Tyr Tyr Phe Arg Thr Pro Glu Ile Asn
                405                 410                 415     
Asn Ser Ser Gly Glu Met Asp Pro Ile Leu Leu Thr Ile Ser Ile Leu
            420                 425                 430         
Ser Phe Phe Ser Val Ala Leu Leu Val Ile Leu Ala Cys Val Leu Trp
        435                 440                 445             
Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn
    450                 455                 460                 
Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly
465                 470                 475                 480 
Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe
                485                 490                 495     
Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu
            500                 505                 510         
Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu
        515                 520                 525             
Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn
    530                 535                 540                 
Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala
545                 550                 555                 560 
Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp
                565                 570                 575     
Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln
            580                 585                 590         
Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp
        595                 600                 605             
Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro
    610                 615                 620                 
Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro
625                 630                 635                 640 
Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly
                645                 650                 655     
Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro
            660                 665                 670         
Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro
        675                 680                 685             
Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu
    690                 695                 700                 
Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu
705                 710                 715                 720 
Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val
                725                 730                 


<210> 90
<211> 1014
<212> DNA
<213> Unknown

<220> 
<223> PD1ECD-IFNALPHA

<400> 90
atgcagatcc ctcaggcccc ttggcctgtc gtgtgggctg tgctgcagct gggatggcgg 60
cctggctggt ttctggacag ccccgacaga ccctggaacc cccctacatt ttcccctgcc 120
ctgctggtcg tgaccgaggg cgacaatgcc accttcacct gtagcttcag caacaccagc 180
gagagcttcg tgctgaactg gtacagaatg agccccagca accagaccga caagctggcc 240
gccttccccg aggatagatc tcagcccggc caggactgcc ggttcagagt gacccagctg 300
cccaacggcc gggacttcca catgtctgtc gtgcgggcca gacggaacga cagcggcaca 360
tatctgtgcg gcgccatcag cctggccccc aaggcccaga tcaaagagag cctgagagcc 420
gagctgagag tgaccgagag aagggccgaa gtgcctaccg cccaccctag cccatctcca 480
agacctgccg gccagttcca gacactcgtg ggcggaggat gcgacctgcc tcagacacac 540
agcctgggca gcagacggac cctgatgctg ctggcccaga tgcggaagat cagcctgttc 600
agctgcctga aggaccggca cgacttcggc ttccctcagg aagagttcgg caaccagttt 660
cagaaggccg agacaatccc cgtgctgcac gagatgatcc agcagatctt caacctgttc 720
tccaccaagg acagcagcgc cgcctgggac gagacactgc tggacaagtt ctacaccgag 780
ctgtaccagc agctgaatga cctggaagcc tgcgtgatcc agggcgtggg cgtgacagag 840
acacccctga tgaaggaaga tagcatcctg gccgtgcgca agtacttcca gcggatcacc 900
ctgtacctga aagagaagaa gtacagcccc tgcgcctggg aggtcgtgcg cgccgagatc 960
atgagaagct tcagcctgag caccaacctg caggaaagcc tgcggagcaa agaa       1014

<210> 91
<211> 338
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD1ECD-IFNALPHA

<400> 91
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln
 1               5                  10                  15      
Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp
            20                  25                  30          
Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp
        35                  40                  45              
Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val
    50                  55                  60                  
Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala
65                  70                  75                  80  
Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg
                85                  90                  95      
Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg
            100                 105                 110         
Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu
        115                 120                 125             
Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val
    130                 135                 140                 
Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro
145                 150                 155                 160 
Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Gly Gly Gly Cys Asp Leu
                165                 170                 175     
Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met Leu Leu Ala
            180                 185                 190         
Gln Met Arg Lys Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg His Asp
        195                 200                 205             
Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu
    210                 215                 220                 
Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Asn Leu Phe
225                 230                 235                 240 
Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys
                245                 250                 255     
Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val
            260                 265                 270         
Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys Glu Asp Ser
        275                 280                 285             
Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys
    290                 295                 300                 
Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile
305                 310                 315                 320 
Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser
                325                 330                 335     
Lys Glu
        


<210> 92
<211> 2382
<212> DNA
<213> Unknown

<220> 
<223> STAT5A

<400> 92
atggcgggct ggatccaggc ccagcagctg cagggagacg cgctgcgcca gatgcaggtg 60
ctgtacggcc agcacttccc catcgaggtc cggcactact tggcccagtg gattgagagc 120
cagccatggg atgccattga cttggacaat ccccaggaca gagcccaagc cacccagctc 180
ctggagggcc tggtgcagga gctgcagaag aaggcggagc accaggtggg ggaagatggg 240
tttttactga agatcaagct ggggcactac gccacgcagc tccagaaaac atatgaccgc 300
tgccccctgg agctggtccg ctgcatccgg cacattctgt acaatgaaca gaggctggtc 360
cgagaagcca acaattgcag ctctccggct gggatcctgg ttgacgccat gtcccagaag 420
caccttcaga tcaaccagac atttgaggag ctgcgactgg tcacgcagga cacagagaat 480
gagctgaaga aactgcagca gactcaggag tacttcatca tccagtacca ggagagcctg 540
aggatccaag ctcagtttgc ccagctggcc cagctgagcc cccaggagcg tctgagccgg 600
gagacggccc tccagcagaa gcaggtgtct ctggaggcct ggttgcagcg tgaggcacag 660
acactgcagc agtaccgcgt ggagctggcc gagaagcacc agaagaccct gcagctgctg 720
cggaagcagc agaccatcat cctggatgac gagctgatcc agtggaagcg gcggcagcag 780
ctggccggga acggcgggcc ccccgagggc agcctggacg tgctacagtc ctggtgtgag 840
aagttggccg agatcatctg gcagaaccgg cagcagatcc gcagggctga gcacctctgc 900
cagcagctgc ccatccccgg cccagtggag gagatgctgg ccgaggtcaa cgccaccatc 960
acggacatta tctcagccct ggtgaccagc acattcatca ttgagaagca gcctcctcag 1020
gtcctgaaga cccagaccaa gtttgcagcc accgtacgcc tgctggtggg cgggaagctg 1080
aacgtgcaca tgaatccccc ccaggtgaag gccaccatca tcagtgagca gcaggccaag 1140
tctctgctta aaaatgagaa cacccgcaac gagtgcagtg gtgagatcct gaacaactgc 1200
tgcgtgatgg agtaccacca agccacgggc accctcagtg cccacttcag gaacatgtca 1260
ctgaagagga tcaagcgtgc tgaccggcgg ggtgcagagt ccgtgacaga ggagaagttc 1320
acagtcctgt ttgagtctca gttcagtgtt ggcagcaatg agcttgtgtt ccaggtgaag 1380
actctgtccc tacctgtggt tgtcatcgtc cacggcagcc aggaccacaa tgccacggct 1440
actgtgctgt gggacaatgc ctttgctgag ccgggcaggg tgccatttgc cgtgcctgac 1500
aaagtgctgt ggccgcagct gtgtgaggcg ctcaacatga aattcaaggc cgaagtgcag 1560
agcaaccggg gcctgaccaa ggagaacctc gtgttcctgg cgcagaaact gttcaacaac 1620
agcagcagcc acctggagga ctacagtggc ctgtccgtgt cctggtccca gttcaacagg 1680
gagaacttgc cgggctggaa ctacaccttc tggcagtggt ttgacggggt gatggaggtg 1740
ttgaagaagc accacaagcc ccactggaat gatggggcca tcctaggttt tgtgaataag 1800
caacaggccc acgacctgct catcaacaag cccgacggga ccttcttgtt gcgctttagt 1860
gactcagaaa tcgggggcat caccatcgcc tggaagtttg attccccgga acgcaacctg 1920
tggaacctga aaccattcac cacgcgggat ttctccatca ggtccctggc tgaccggctg 1980
ggggacctga gctatctcat ctatgtgttt cctgaccgcc ccaaggatga ggtcttctcc 2040
aagtactaca ctcctgtgct ggctaaagct gttgatggat atgtgaaacc acagatcaag 2100
caagtggtcc ctgagtttgt gaatgcatct gcagatgctg ggggcagcag cgccacgtac 2160
atggaccagg ccccctcccc agctgtgtgc ccccaggctc cctataacat gtacccacag 2220
aaccctgacc atgtactcga tcaggatgga gaattcgacc tggatgagac catggatgtg 2280
gccaggcacg tggaggaact cttacgccga ccaatggaca gtcttgactc ccgcctctcg 2340
ccccctgccg gtcttttcac ctctgccaga ggctccctct ca                    2382

<210> 93
<211> 794
<212> PRT
<213> Artificial Sequence

<220> 
<223> STAT5A

<400> 93
Met Ala Gly Trp Ile Gln Ala Gln Gln Leu Gln Gly Asp Ala Leu Arg
 1               5                  10                  15      
Gln Met Gln Val Leu Tyr Gly Gln His Phe Pro Ile Glu Val Arg His
            20                  25                  30          
Tyr Leu Ala Gln Trp Ile Glu Ser Gln Pro Trp Asp Ala Ile Asp Leu
        35                  40                  45              
Asp Asn Pro Gln Asp Arg Ala Gln Ala Thr Gln Leu Leu Glu Gly Leu
    50                  55                  60                  
Val Gln Glu Leu Gln Lys Lys Ala Glu His Gln Val Gly Glu Asp Gly
65                  70                  75                  80  
Phe Leu Leu Lys Ile Lys Leu Gly His Tyr Ala Thr Gln Leu Gln Lys
                85                  90                  95      
Thr Tyr Asp Arg Cys Pro Leu Glu Leu Val Arg Cys Ile Arg His Ile
            100                 105                 110         
Leu Tyr Asn Glu Gln Arg Leu Val Arg Glu Ala Asn Asn Cys Ser Ser
        115                 120                 125             
Pro Ala Gly Ile Leu Val Asp Ala Met Ser Gln Lys His Leu Gln Ile
    130                 135                 140                 
Asn Gln Thr Phe Glu Glu Leu Arg Leu Val Thr Gln Asp Thr Glu Asn
145                 150                 155                 160 
Glu Leu Lys Lys Leu Gln Gln Thr Gln Glu Tyr Phe Ile Ile Gln Tyr
                165                 170                 175     
Gln Glu Ser Leu Arg Ile Gln Ala Gln Phe Ala Gln Leu Ala Gln Leu
            180                 185                 190         
Ser Pro Gln Glu Arg Leu Ser Arg Glu Thr Ala Leu Gln Gln Lys Gln
        195                 200                 205             
Val Ser Leu Glu Ala Trp Leu Gln Arg Glu Ala Gln Thr Leu Gln Gln
    210                 215                 220                 
Tyr Arg Val Glu Leu Ala Glu Lys His Gln Lys Thr Leu Gln Leu Leu
225                 230                 235                 240 
Arg Lys Gln Gln Thr Ile Ile Leu Asp Asp Glu Leu Ile Gln Trp Lys
                245                 250                 255     
Arg Arg Gln Gln Leu Ala Gly Asn Gly Gly Pro Pro Glu Gly Ser Leu
            260                 265                 270         
Asp Val Leu Gln Ser Trp Cys Glu Lys Leu Ala Glu Ile Ile Trp Gln
        275                 280                 285             
Asn Arg Gln Gln Ile Arg Arg Ala Glu His Leu Cys Gln Gln Leu Pro
    290                 295                 300                 
Ile Pro Gly Pro Val Glu Glu Met Leu Ala Glu Val Asn Ala Thr Ile
305                 310                 315                 320 
Thr Asp Ile Ile Ser Ala Leu Val Thr Ser Thr Phe Ile Ile Glu Lys
                325                 330                 335     
Gln Pro Pro Gln Val Leu Lys Thr Gln Thr Lys Phe Ala Ala Thr Val
            340                 345                 350         
Arg Leu Leu Val Gly Gly Lys Leu Asn Val His Met Asn Pro Pro Gln
        355                 360                 365             
Val Lys Ala Thr Ile Ile Ser Glu Gln Gln Ala Lys Ser Leu Leu Lys
    370                 375                 380                 
Asn Glu Asn Thr Arg Asn Glu Cys Ser Gly Glu Ile Leu Asn Asn Cys
385                 390                 395                 400 
Cys Val Met Glu Tyr His Gln Ala Thr Gly Thr Leu Ser Ala His Phe
                405                 410                 415     
Arg Asn Met Ser Leu Lys Arg Ile Lys Arg Ala Asp Arg Arg Gly Ala
            420                 425                 430         
Glu Ser Val Thr Glu Glu Lys Phe Thr Val Leu Phe Glu Ser Gln Phe
        435                 440                 445             
Ser Val Gly Ser Asn Glu Leu Val Phe Gln Val Lys Thr Leu Ser Leu
    450                 455                 460                 
Pro Val Val Val Ile Val His Gly Ser Gln Asp His Asn Ala Thr Ala
465                 470                 475                 480 
Thr Val Leu Trp Asp Asn Ala Phe Ala Glu Pro Gly Arg Val Pro Phe
                485                 490                 495     
Ala Val Pro Asp Lys Val Leu Trp Pro Gln Leu Cys Glu Ala Leu Asn
            500                 505                 510         
Met Lys Phe Lys Ala Glu Val Gln Ser Asn Arg Gly Leu Thr Lys Glu
        515                 520                 525             
Asn Leu Val Phe Leu Ala Gln Lys Leu Phe Asn Asn Ser Ser Ser His
    530                 535                 540                 
Leu Glu Asp Tyr Ser Gly Leu Ser Val Ser Trp Ser Gln Phe Asn Arg
545                 550                 555                 560 
Glu Asn Leu Pro Gly Trp Asn Tyr Thr Phe Trp Gln Trp Phe Asp Gly
                565                 570                 575     
Val Met Glu Val Leu Lys Lys His His Lys Pro His Trp Asn Asp Gly
            580                 585                 590         
Ala Ile Leu Gly Phe Val Asn Lys Gln Gln Ala His Asp Leu Leu Ile
        595                 600                 605             
Asn Lys Pro Asp Gly Thr Phe Leu Leu Arg Phe Ser Asp Ser Glu Ile
    610                 615                 620                 
Gly Gly Ile Thr Ile Ala Trp Lys Phe Asp Ser Pro Glu Arg Asn Leu
625                 630                 635                 640 
Trp Asn Leu Lys Pro Phe Thr Thr Arg Asp Phe Ser Ile Arg Ser Leu
                645                 650                 655     
Ala Asp Arg Leu Gly Asp Leu Ser Tyr Leu Ile Tyr Val Phe Pro Asp
            660                 665                 670         
Arg Pro Lys Asp Glu Val Phe Ser Lys Tyr Tyr Thr Pro Val Leu Ala
        675                 680                 685             
Lys Ala Val Asp Gly Tyr Val Lys Pro Gln Ile Lys Gln Val Val Pro
    690                 695                 700                 
Glu Phe Val Asn Ala Ser Ala Asp Ala Gly Gly Ser Ser Ala Thr Tyr
705                 710                 715                 720 
Met Asp Gln Ala Pro Ser Pro Ala Val Cys Pro Gln Ala Pro Tyr Asn
                725                 730                 735     
Met Tyr Pro Gln Asn Pro Asp His Val Leu Asp Gln Asp Gly Glu Phe
            740                 745                 750         
Asp Leu Asp Glu Thr Met Asp Val Ala Arg His Val Glu Glu Leu Leu
        755                 760                 765             
Arg Arg Pro Met Asp Ser Leu Asp Ser Arg Leu Ser Pro Pro Ala Gly
    770                 775                 780                 
Leu Phe Thr Ser Ala Arg Gly Ser Leu Ser
785                 790                 


<210> 94
<211> 2382
<212> DNA
<213> Unknown

<220> 
<223> constitutively active-STAT5A

<400> 94
atggcgggct ggatccaggc ccagcagctg cagggagacg cgctgcgcca gatgcaggtg 60
ctgtacggcc agcacttccc catcgaggtc cggcactact tggcccagtg gattgagagc 120
cagccatggg atgccattga cttggacaat ccccaggaca gagcccaagc cacccagctc 180
ctggagggcc tggtgcagga gctgcagaag aaggcggagc accaggtggg ggaagatggg 240
tttttactga agatcaagct ggggcactac gccacgcagc tccagaaaac atatgaccgc 300
tgccccctgg agctggtccg ctgcatccgg cacattctgt acaatgaaca gaggctggtc 360
cgagaagcca acaattgcag ctctccggct gggatcctgg ttgacgccat gtcccagaag 420
caccttcaga tcaaccagac atttgaggag ctgcgactgg tcacgcagga cacagagaat 480
gagctgaaga aactgcagca gactcaggag tacttcatca tccagtacca ggagagcctg 540
aggatccaag ctcagtttgc ccagctggcc cagctgagcc cccaggagcg tctgagccgg 600
gagacggccc tccagcagaa gcaggtgtct ctggaggcct ggttgcagcg tgaggcacag 660
acactgcagc agtaccgcgt ggagctggcc gagaagcacc agaagaccct gcagctgctg 720
cggaagcagc agaccatcat cctggatgac gagctgatcc agtggaagcg gcggcagcag 780
ctggccggga acggcgggcc ccccgagggc agcctggacg tgctacagtc ctggtgtgag 840
aagttggccg agatcatctg gcagaaccgg cagcagatcc gcagggctga gcgcctctgc 900
cagcagctgc ccatccccgg cccagtggag gagatgctgg ccgaggtcaa cgccaccatc 960
acggacatta tctcagccct ggtgaccagc acattcatca ttgagaagca gcctcctcag 1020
gtcctgaaga cccagaccaa gtttgcagcc accgtacgcc tgctggtggg cgggaagctg 1080
aacgtgcaca tgaatccccc ccaggtgaag gccaccatca tcagtgagca gcaggccaag 1140
tctctgctta aaaatgagaa cacccgcaac gagtgcagtg gtgagatcct gaacaactgc 1200
tgcgtgatgg agtaccacca agccacgggc accctcagtg cccacttcag gaacatgtca 1260
ctgaagagga tcaagcgtgc tgaccggcgg ggtgcagagt ccgtgacaga ggagaagttc 1320
acagtcctgt ttgagtctca gttcagtgtt ggcagcaatg agcttgtgtt ccaggtgaag 1380
actctgtccc tacctgtggt tgtcatcgtc cacggcagcc aggaccacaa tgccacggct 1440
actgtgctgt gggacaatgc ctttgctgag ccgggcaggg tgccatttgc cgtgcctgac 1500
aaagtgctgt ggccgcagct gtgtgaggcg ctcaacatga aattcaaggc cgaagtgcag 1560
agcaaccggg gcctgaccaa ggagaacctc gtgttcctgg cgcagaaact gttcaacaac 1620
agcagcagcc acctggagga ctacagtggc ctgtccgtgt cctggtccca gttcaacagg 1680
gagaacttgc cgggctggaa ctacaccttc tggcagtggt ttgacggggt gatggaggtg 1740
ttgaagaagc accacaagcc ccactggaat gatggggcca tcctaggttt tgtgaataag 1800
caacaggccc acgacctgct catcaacaag cccgacggga ccttcttgtt gcgctttagt 1860
gactcagaaa tcgggggcat caccatcgcc tggaagtttg attccccgga acgcaacctg 1920
tggaacctga aaccattcac cacgcgggat ttctccatca ggtccctggc tgaccggctg 1980
ggggacctga gctatctcat ctatgtgttt cctgaccgcc ccaaggatga ggtcttctcc 2040
aagtactaca ctcctgtgct ggctaaagct gttgatggat atgtgaaacc acagatcaag 2100
caagtggtcc ctgagtttgt gaatgcattt gcagatgctg ggggcagcag cgccacgtac 2160
atggaccagg ccccctcccc agctgtgtgc ccccaggctc cctataacat gtacccacag 2220
aaccctgacc atgtactcga tcaggatgga gaattcgacc tggatgagac catggatgtg 2280
gccaggcacg tggaggaact cttacgccga ccaatggaca gtcttgactc ccgcctctcg 2340
ccccctgccg gtcttttcac ctctgccaga ggctccctct ca                    2382

<210> 95
<211> 794
<212> PRT
<213> Artificial Sequence

<220> 
<223> constitutively active-STAT5A

<220> 
<223> constitutively active-STAT5A

<400> 95
Met Ala Gly Trp Ile Gln Ala Gln Gln Leu Gln Gly Asp Ala Leu Arg
 1               5                  10                  15      
Gln Met Gln Val Leu Tyr Gly Gln His Phe Pro Ile Glu Val Arg His
            20                  25                  30          
Tyr Leu Ala Gln Trp Ile Glu Ser Gln Pro Trp Asp Ala Ile Asp Leu
        35                  40                  45              
Asp Asn Pro Gln Asp Arg Ala Gln Ala Thr Gln Leu Leu Glu Gly Leu
    50                  55                  60                  
Val Gln Glu Leu Gln Lys Lys Ala Glu His Gln Val Gly Glu Asp Gly
65                  70                  75                  80  
Phe Leu Leu Lys Ile Lys Leu Gly His Tyr Ala Thr Gln Leu Gln Lys
                85                  90                  95      
Thr Tyr Asp Arg Cys Pro Leu Glu Leu Val Arg Cys Ile Arg His Ile
            100                 105                 110         
Leu Tyr Asn Glu Gln Arg Leu Val Arg Glu Ala Asn Asn Cys Ser Ser
        115                 120                 125             
Pro Ala Gly Ile Leu Val Asp Ala Met Ser Gln Lys His Leu Gln Ile
    130                 135                 140                 
Asn Gln Thr Phe Glu Glu Leu Arg Leu Val Thr Gln Asp Thr Glu Asn
145                 150                 155                 160 
Glu Leu Lys Lys Leu Gln Gln Thr Gln Glu Tyr Phe Ile Ile Gln Tyr
                165                 170                 175     
Gln Glu Ser Leu Arg Ile Gln Ala Gln Phe Ala Gln Leu Ala Gln Leu
            180                 185                 190         
Ser Pro Gln Glu Arg Leu Ser Arg Glu Thr Ala Leu Gln Gln Lys Gln
        195                 200                 205             
Val Ser Leu Glu Ala Trp Leu Gln Arg Glu Ala Gln Thr Leu Gln Gln
    210                 215                 220                 
Tyr Arg Val Glu Leu Ala Glu Lys His Gln Lys Thr Leu Gln Leu Leu
225                 230                 235                 240 
Arg Lys Gln Gln Thr Ile Ile Leu Asp Asp Glu Leu Ile Gln Trp Lys
                245                 250                 255     
Arg Arg Gln Gln Leu Ala Gly Asn Gly Gly Pro Pro Glu Gly Ser Leu
            260                 265                 270         
Asp Val Leu Gln Ser Trp Cys Glu Lys Leu Ala Glu Ile Ile Trp Gln
        275                 280                 285             
Asn Arg Gln Gln Ile Arg Arg Ala Glu Arg Leu Cys Gln Gln Leu Pro
    290                 295                 300                 
Ile Pro Gly Pro Val Glu Glu Met Leu Ala Glu Val Asn Ala Thr Ile
305                 310                 315                 320 
Thr Asp Ile Ile Ser Ala Leu Val Thr Ser Thr Phe Ile Ile Glu Lys
                325                 330                 335     
Gln Pro Pro Gln Val Leu Lys Thr Gln Thr Lys Phe Ala Ala Thr Val
            340                 345                 350         
Arg Leu Leu Val Gly Gly Lys Leu Asn Val His Met Asn Pro Pro Gln
        355                 360                 365             
Val Lys Ala Thr Ile Ile Ser Glu Gln Gln Ala Lys Ser Leu Leu Lys
    370                 375                 380                 
Asn Glu Asn Thr Arg Asn Glu Cys Ser Gly Glu Ile Leu Asn Asn Cys
385                 390                 395                 400 
Cys Val Met Glu Tyr His Gln Ala Thr Gly Thr Leu Ser Ala His Phe
                405                 410                 415     
Arg Asn Met Ser Leu Lys Arg Ile Lys Arg Ala Asp Arg Arg Gly Ala
            420                 425                 430         
Glu Ser Val Thr Glu Glu Lys Phe Thr Val Leu Phe Glu Ser Gln Phe
        435                 440                 445             
Ser Val Gly Ser Asn Glu Leu Val Phe Gln Val Lys Thr Leu Ser Leu
    450                 455                 460                 
Pro Val Val Val Ile Val His Gly Ser Gln Asp His Asn Ala Thr Ala
465                 470                 475                 480 
Thr Val Leu Trp Asp Asn Ala Phe Ala Glu Pro Gly Arg Val Pro Phe
                485                 490                 495     
Ala Val Pro Asp Lys Val Leu Trp Pro Gln Leu Cys Glu Ala Leu Asn
            500                 505                 510         
Met Lys Phe Lys Ala Glu Val Gln Ser Asn Arg Gly Leu Thr Lys Glu
        515                 520                 525             
Asn Leu Val Phe Leu Ala Gln Lys Leu Phe Asn Asn Ser Ser Ser His
    530                 535                 540                 
Leu Glu Asp Tyr Ser Gly Leu Ser Val Ser Trp Ser Gln Phe Asn Arg
545                 550                 555                 560 
Glu Asn Leu Pro Gly Trp Asn Tyr Thr Phe Trp Gln Trp Phe Asp Gly
                565                 570                 575     
Val Met Glu Val Leu Lys Lys His His Lys Pro His Trp Asn Asp Gly
            580                 585                 590         
Ala Ile Leu Gly Phe Val Asn Lys Gln Gln Ala His Asp Leu Leu Ile
        595                 600                 605             
Asn Lys Pro Asp Gly Thr Phe Leu Leu Arg Phe Ser Asp Ser Glu Ile
    610                 615                 620                 
Gly Gly Ile Thr Ile Ala Trp Lys Phe Asp Ser Pro Glu Arg Asn Leu
625                 630                 635                 640 
Trp Asn Leu Lys Pro Phe Thr Thr Arg Asp Phe Ser Ile Arg Ser Leu
                645                 650                 655     
Ala Asp Arg Leu Gly Asp Leu Ser Tyr Leu Ile Tyr Val Phe Pro Asp
            660                 665                 670         
Arg Pro Lys Asp Glu Val Phe Ser Lys Tyr Tyr Thr Pro Val Leu Ala
        675                 680                 685             
Lys Ala Val Asp Gly Tyr Val Lys Pro Gln Ile Lys Gln Val Val Pro
    690                 695                 700                 
Glu Phe Val Asn Ala Phe Ala Asp Ala Gly Gly Ser Ser Ala Thr Tyr
705                 710                 715                 720 
Met Asp Gln Ala Pro Ser Pro Ala Val Cys Pro Gln Ala Pro Tyr Asn
                725                 730                 735     
Met Tyr Pro Gln Asn Pro Asp His Val Leu Asp Gln Asp Gly Glu Phe
            740                 745                 750         
Asp Leu Asp Glu Thr Met Asp Val Ala Arg His Val Glu Glu Leu Leu
        755                 760                 765             
Arg Arg Pro Met Asp Ser Leu Asp Ser Arg Leu Ser Pro Pro Ala Gly
    770                 775                 780                 
Leu Phe Thr Ser Ala Arg Gly Ser Leu Ser
785                 790                 


<210> 96
<211> 837
<212> DNA
<213> Unknown

<220> 
<223> dominant negative TGFB-RII

<400> 96
atgggtcggg ggctgctcag gggcctgtgg ccgctgcaca tcgtcctgtg gacgcgtatc 60
gccagcacga tcccaccgca cgttcagaag tcggttaata acgacatgat agtcactgac 120
aacaacggtg cagtcaagtt tccacaactg tgtaaatttt gtgatgtgag attttccacc 180
tgtgacaacc agaaatcctg catgagcaac tgcagcatca cctccatctg tgagaagcca 240
caggaagtct gtgtggctgt atggagaaag aatgacgaga acataacact agagacagtt 300
tgccatgacc ccaagctccc ctaccatgac tttattctgg aagatgctgc ttctccaaag 360
tgcattatga aggaaaaaaa aaagcctggt gagactttct tcatgtgttc ctgtagctct 420
gatgagtgca atgacaacat catcttctca gaagaatata acaccagcaa tcctgacttg 480
ttgctagtca tatttcaagt gacaggcatc agcctcctgc caccactggg agttgccata 540
tctgtcatca tcatcttcta ctgctaccgc gttaaccggc agcagaagct gagttcaacc 600
tgggaaaccg gcaagacgcg gaagctcatg gagttcagcg agcactgtgc catcatcctg 660
gaagatgacc gctctgacat cagctccacg tgtgccaaca acatcaacca caacacagag 720
ctgctgccca ttgagctgga caccctggtg gggaaaggtc gctttgctga ggtctataag 780
gccaagctga agcagaacac ttcagagcag tttgagacag tggcagtcaa gatcttt    837

<210> 97
<211> 279
<212> PRT
<213> Artificial Sequence

<220> 
<223> dominant negative TGFBRII

<400> 97
Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu
 1               5                  10                  15      
Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val
            20                  25                  30          
Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro
        35                  40                  45              
Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln
    50                  55                  60                  
Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro
65                  70                  75                  80  
Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr
                85                  90                  95      
Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile
            100                 105                 110         
Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys
        115                 120                 125             
Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn
    130                 135                 140                 
Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu
145                 150                 155                 160 
Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu
                165                 170                 175     
Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn
            180                 185                 190         
Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys
        195                 200                 205             
Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile Leu Glu Asp Asp Arg
    210                 215                 220                 
Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile Asn His Asn Thr Glu
225                 230                 235                 240 
Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly Lys Gly Arg Phe Ala
                245                 250                 255     
Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr Ser Glu Gln Phe Glu
            260                 265                 270         
Thr Val Ala Val Lys Ile Phe
        275                 


<210> 98
<211> 1788
<212> DNA
<213> Unknown

<220> 
<223> dominant negative SHP1

<400> 98
atggtgaggt ggtttcaccg agacctcagt gggctggatg cagagaccct gctcaagggc 60
cgaggtgtcc acggtagctt cctggctcgg cccagtcgca agaaccaggg tgacttctcg 120
ctctccgtca gggtggggga tcaggtgacc catattcgga tccagaactc aggggatttc 180
tatgacctgt atggagggga gaagtttgcg actctgacag agctggtgga gtactacact 240
cagcagcagg gtgtcctgca ggaccgcgac ggcaccatca tccacctcaa gtacccgctg 300
aactgctccg atcccactag tgagaggtgg taccatggcc acatgtctgg cgggcaggca 360
gagacgctgc tgcaggccaa gggcgagccc tggacgtttc ttgtgcgtga gagcctcagc 420
cagcctggag acttcgtgct ttctgtgctc agtgaccagc ccaaggctgg cccaggctcc 480
ccgctcaggg tcacccacat caaggtcatg tgcgagggtg gacgctacac agtgggtggt 540
ttggagacct tcgacagcct cacggacctg gtggagcatt tcaagaagac ggggattgag 600
gaggcctcag gcgcctttgt ctacctgcgg cagccgtact atgccacgag ggtgaatgcg 660
gctgacattg agaaccgagt gttggaactg aacaagaagc aggagtccga ggatacagcc 720
aaggctggct tctgggagga gtttgagagt ttgcagaagc aggaggtgaa gaacttgcac 780
cagcgtctgg aagggcagcg gccagagaac aagggcaaga accgctacaa gaacattctc 840
ccctttgacc acagccgagt gatcctgcag ggacgggaca gtaacatccc cgggtccgac 900
tacatcaatg ccaactacat caagaaccag ctgctaggcc ctgatgagaa cgctaagacc 960
tacatcgcca gccagggctg tctggaggcc acggtcaatg acttctggca gatggcgtgg 1020
caggagaaca gccgtgtcat cgtcatgacc acccgagagg tggagaaagg ccggaacaaa 1080
tgcgtcccat actggcccga ggtgggcatg cagcgtgctt atgggcccta ctctgtgacc 1140
aactgcgggg agcatgacac aaccgaatac aaactccgta ccttacaggt ctccccgctg 1200
gacaatggag acctgattcg ggagatctgg cattaccagt acctgagctg gcccgaccat 1260
ggggtcccca gtgagcctgg gggtgtcctc agcttcctgg accagatcaa ccagcggcag 1320
gaaagtctgc ctcacgcagg gcccatcatc gtgcactcca gcgccggcat cggccgcaca 1380
ggcaccatca ttgtcatcga catgctcatg gagaacatct ccaccaaggg cctggactgt 1440
gacattgaca tccagaagac catccagatg gtgcgggcgc agcgctcggg catggtgcag 1500
acggaggcgc agtacaagtt catctacgtg gccatcgccc agttcattga aaccactaag 1560
aagaagctgg aggtcctgca gtcgcagaag ggccaggagt cggagtacgg gaacatcacc 1620
tatcccccag ccatgaagaa tgcccatgcc aaggcctccc gcacctcgtc caaacacaag 1680
gaggatgtgt atgagaacct gcacactaag aacaagaggg aggagaaagt gaagaagcag 1740
cggtcagcag acaaggagaa gagcaagggt tccctcaaga ggaagtga              1788

<210> 99
<211> 595
<212> PRT
<213> Artificial Sequence

<220> 
<223> dominant negative SHP1

<400> 99
Met Val Arg Trp Phe His Arg Asp Leu Ser Gly Leu Asp Ala Glu Thr
 1               5                  10                  15      
Leu Leu Lys Gly Arg Gly Val His Gly Ser Phe Leu Ala Arg Pro Ser
            20                  25                  30          
Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Val Arg Val Gly Asp Gln
        35                  40                  45              
Val Thr His Ile Arg Ile Gln Asn Ser Gly Asp Phe Tyr Asp Leu Tyr
    50                  55                  60                  
Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Leu Val Glu Tyr Tyr Thr
65                  70                  75                  80  
Gln Gln Gln Gly Val Leu Gln Asp Arg Asp Gly Thr Ile Ile His Leu
                85                  90                  95      
Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Ser Glu Arg Trp Tyr His
            100                 105                 110         
Gly His Met Ser Gly Gly Gln Ala Glu Thr Leu Leu Gln Ala Lys Gly
        115                 120                 125             
Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Leu Ser Gln Pro Gly Asp
    130                 135                 140                 
Phe Val Leu Ser Val Leu Ser Asp Gln Pro Lys Ala Gly Pro Gly Ser
145                 150                 155                 160 
Pro Leu Arg Val Thr His Ile Lys Val Met Cys Glu Gly Gly Arg Tyr
                165                 170                 175     
Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Leu Thr Asp Leu Val Glu
            180                 185                 190         
His Phe Lys Lys Thr Gly Ile Glu Glu Ala Ser Gly Ala Phe Val Tyr
        195                 200                 205             
Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val Asn Ala Ala Asp Ile Glu
    210                 215                 220                 
Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Glu Ser Glu Asp Thr Ala
225                 230                 235                 240 
Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Leu Gln Lys Gln Glu Val
                245                 250                 255     
Lys Asn Leu His Gln Arg Leu Glu Gly Gln Arg Pro Glu Asn Lys Gly
            260                 265                 270         
Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Ser Arg Val Ile
        275                 280                 285             
Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Ser Asp Tyr Ile Asn Ala
    290                 295                 300                 
Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro Asp Glu Asn Ala Lys Thr
305                 310                 315                 320 
Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Thr Val Asn Asp Phe Trp
                325                 330                 335     
Gln Met Ala Trp Gln Glu Asn Ser Arg Val Ile Val Met Thr Thr Arg
            340                 345                 350         
Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pro Tyr Trp Pro Glu Val
        355                 360                 365             
Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Val Thr Asn Cys Gly Glu
    370                 375                 380                 
His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Leu Gln Val Ser Pro Leu
385                 390                 395                 400 
Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp His Tyr Gln Tyr Leu Ser
                405                 410                 415     
Trp Pro Asp His Gly Val Pro Ser Glu Pro Gly Gly Val Leu Ser Phe
            420                 425                 430         
Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Leu Pro His Ala Gly Pro
        435                 440                 445             
Ile Ile Val His Ser Ser Ala Gly Ile Gly Arg Thr Gly Thr Ile Ile
    450                 455                 460                 
Val Ile Asp Met Leu Met Glu Asn Ile Ser Thr Lys Gly Leu Asp Cys
465                 470                 475                 480 
Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Val Arg Ala Gln Arg Ser
                485                 490                 495     
Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Phe Ile Tyr Val Ala Ile
            500                 505                 510         
Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Leu Glu Val Leu Gln Ser
        515                 520                 525             
Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Ile Thr Tyr Pro Pro Ala
    530                 535                 540                 
Met Lys Asn Ala His Ala Lys Ala Ser Arg Thr Ser Ser Lys His Lys
545                 550                 555                 560 
Glu Asp Val Tyr Glu Asn Leu His Thr Lys Asn Lys Arg Glu Glu Lys
                565                 570                 575     
Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Lys Ser Lys Gly Ser Leu
            580                 585                 590         
Lys Arg Lys
        595 


<210> 100
<211> 1035
<212> DNA
<213> Unknown

<220> 
<223> PD1TM-MYD88

<400> 100
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg 60
atcccaggcg gaggagtggg agtcgtgggc ggactgctgg gatctctggt gctgctcgtg 120
tgggtgctgg ccgtgattgg cggaggaatg gctgctggcg gacctggcgc tggatctgct 180
gctcctgtgt ctagcaccag cagcctgcct ctggccgccc tgaatatgag agtgcggcgg 240
agactgagcc tgttcctgaa cgtgcggaca caggtggccg ccgattggac agctctggcc 300
gaggaaatgg acttcgagta cctggaaatc cggcagctgg aaacccaggc cgaccctaca 360
ggacgcctgc tggatgcttg gcagggcaga ccaggcgctt ctgtggggag actgctggaa 420
ctgctgacca agctgggccg ggacgacgtg ctgctggaac tgggccctag catcgaagag 480
gactgccaga agtacatcct gaagcagcag caggaagagg ccgagaagcc tctgcaggtg 540
gcagccgtgg atagcagcgt gccaagaaca gctgagctgg ccggaatcac caccctggac 600
gatcctctgg gccacatgcc cgagagattc gacgccttca tctgctactg ccccagcgac 660
atccagttcg tgcaggaaat gatcagacag ctggaacaga ccaactaccg gctgaagctg 720
tgcgtgtccg accgggatgt gctgcctggc acctgtgtgt ggtctatcgc cagcgagctg 780
atcgagaagc ggtgcagacg gatggtcgtg gtggtgtccg acgactacct gcagtccaaa 840
gagtgcgact tccagaccaa gttcgccctg agcctgagcc ctggcgccca ccagaagaga 900
ctgatcccca tcaagtacaa ggccatgaag aaagagttcc ccagcatcct gcggttcatc 960
accgtgtgcg actacaccaa cccctgcacc aagtcctggt tctggaccag actggccaag 1020
gccctgtctc tgcct                                                  1035

<210> 101
<211> 345
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD1TM-MYD88

<400> 101
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro
 1               5                  10                  15      
Ala Phe Leu Leu Ile Pro Gly Gly Gly Val Gly Val Val Gly Gly Leu
            20                  25                  30          
Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Gly Gly
        35                  40                  45              
Gly Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser
    50                  55                  60                  
Ser Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg
65                  70                  75                  80  
Arg Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp
                85                  90                  95      
Thr Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln
            100                 105                 110         
Leu Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln
        115                 120                 125             
Gly Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys
    130                 135                 140                 
Leu Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu
145                 150                 155                 160 
Asp Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys
                165                 170                 175     
Pro Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu
            180                 185                 190         
Leu Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu
        195                 200                 205             
Arg Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile Gln Phe Val
    210                 215                 220                 
Gln Glu Met Ile Arg Gln Leu Glu Gln Thr Asn Tyr Arg Leu Lys Leu
225                 230                 235                 240 
Cys Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys Val Trp Ser Ile
                245                 250                 255     
Ala Ser Glu Leu Ile Glu Lys Arg Cys Arg Arg Met Val Val Val Val
            260                 265                 270         
Ser Asp Asp Tyr Leu Gln Ser Lys Glu Cys Asp Phe Gln Thr Lys Phe
        275                 280                 285             
Ala Leu Ser Leu Ser Pro Gly Ala His Gln Lys Arg Leu Ile Pro Ile
    290                 295                 300                 
Lys Tyr Lys Ala Met Lys Lys Glu Phe Pro Ser Ile Leu Arg Phe Ile
305                 310                 315                 320 
Thr Val Cys Asp Tyr Thr Asn Pro Cys Thr Lys Ser Trp Phe Trp Thr
                325                 330                 335     
Arg Leu Ala Lys Ala Leu Ser Leu Pro
            340                 345 


<210> 102
<211> 36
<212> DNA
<213> Unknown

<220> 
<223> IGG4 HINGE

<400> 102
gagagcaagt acggaccgcc ctgcccccct tgccct                           36

<210> 103
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> IGG4 HINGE

<400> 103
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro
 1               5                  10          


<210> 104
<211> 330
<212> DNA
<213> Unknown

<220> 
<223> IGG4-CH2(L235D, N297Q)

<400> 104
gcccccgagt tcgacggcgg acccagcgtg ttcctgttcc cccccaagcc caaggacacc 60
ctgatgatca gccggacccc cgaggtgacc tgcgtggtgg tggacgtgag ccaggaagat 120
cccgaggtcc agttcaattg gtacgtggac ggcgtggaag tgcacaacgc caagaccaag 180
cccagagagg aacagttcca gagcacctac cgggtggtgt ctgtgctgac cgtgctgcac 240
caggactggc tgaacggcaa agaatacaag tgcaaggtgt ccaacaaggg cctgcccagc 300
agcatcgaaa agaccatcag caaggccaag                                  330

<210> 105
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> IGG4-CH2(L235D, N297Q)

<400> 105
Ala Pro Glu Phe Asp Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60                  
Gln Phe Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95      
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys
            100                 105                 110 


<210> 106
<211> 321
<212> DNA
<213> Unknown

<220> 
<223> IGG4-CH3

<400> 106
ggccagcctc gcgagcccca ggtgtacacc ctgcctccct cccaggaaga gatgaccaag 60
aaccaggtgt ccctgacctg cctggtgaag ggcttctacc ccagcgacat cgccgtggag 120
tgggagagca acggccagcc tgagaacaac tacaagacca cccctcccgt gctggacagc 180
gacggcagct tcttcctgta cagccggctg accgtggaca agagccggtg gcaggaaggc 240
aacgtcttta gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagagc 300
ctgagcctgt ccctgggcaa g                                           321

<210> 107
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> IGG4-CH3

<400> 107
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu
 1               5                  10                  15      
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
            20                  25                  30          
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
        35                  40                  45              
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
    50                  55                  60                  
Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly
65                  70                  75                  80  
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
                85                  90                  95      
Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
            100                 105         


<210> 108
<211> 225
<212> DNA
<213> Unknown

<220> 
<223> CD8 hinge/transmembrane domain

<400> 108
gaatctaagt acggaccggc caagcctacc accacccctg cccctagacc tccaacaccc 60
gccccaacaa tcgccagcca gcctctgtct ctgaggcccg aggcttgtag accagctgct 120
ggcggagccg tgcacaccag aggactggat ttcgcctgcg acatctacat ctgggcccct 180
ctggccggca catgtggcgt gctgctgctg agcctcgtga tcacc                 225

<210> 109
<211> 75
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD8 hinge/transmembrane domain

<400> 109
Glu Ser Lys Tyr Gly Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg
 1               5                  10                  15      
Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
            20                  25                  30          
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
        35                  40                  45              
Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
    50                  55                  60                  
Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr
65                  70                  75  


<210> 110
<211> 84
<212> DNA
<213> Unknown

<220> 
<223> CD28 transmembrane domain

<400> 110
atgttctggg tgctggtggt ggtcggaggc gtgctggcct gctacagcct gctggtcacc 60
gtggccttca tcatcttttg ggtg                                        84

<210> 111
<211> 28
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD28 transmembrane domain

<400> 111
Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser
 1               5                  10                  15      
Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
            20                  25              


<210> 112
<211> 225
<212> DNA
<213> Unknown

<220> 
<223> CD8 hinge/ transmembrane domain

<400> 112
gaatctaagt acggaccggc caagcctacc accacccctg cccctagacc tccaacaccc 60
gccccaacaa tcgccagcca gcctctgtct ctgaggcccg aggcttgtag accagctgct 120
ggcggagccg tgcacaccag aggactggat ttcgcctgcg acatctacat ctgggcccct 180
ctggccggca catgtggcgt gctgctgctg agcctcgtga tcacc                 225

<210> 113
<211> 75
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD8 hinge/ transmembrane domain

<400> 113
Glu Ser Lys Tyr Gly Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg
 1               5                  10                  15      
Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
            20                  25                  30          
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
        35                  40                  45              
Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
    50                  55                  60                  
Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr
65                  70                  75  


<210> 114
<211> 336
<212> DNA
<213> Unknown

<220> 
<223> CD3 Zeta

<400> 114
cgggtgaagt tcagcagaag cgccgacgcc cctgcctacc agcagggcca gaatcagctg 60
tacaacgagc tgaacctggg cagaagggaa gagtacgacg tcctggataa gcggagaggc 120
cgggaccctg agatgggcgg caagcctcgg cggaagaacc cccaggaagg cctgtataac 180
gaactgcaga aagacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagcgg 240
aggcggggca agggccacga cggcctgtat cagggcctgt ccaccgccac caaggatacc 300
tacgacgccc tgcacatgca ggccctgccc ccaagg                           336

<210> 115
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD3 Zeta

<400> 115
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly
 1               5                  10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys
        35                  40                  45              
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys
    50                  55                  60                  
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg
65                  70                  75                  80  
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala
                85                  90                  95      
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
            100                 105                 110         


<210> 116
<211> 126
<212> DNA
<213> Unknown

<220> 
<223> 4-1BB

<400> 116
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa 60
actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt 120
gaactg                                                            126

<210> 117
<211> 42
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4-1BB

<400> 117
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met
 1               5                  10                  15      
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe
            20                  25                  30          
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu
        35                  40          


<210> 118
<211> 123
<212> DNA
<213> Unknown

<220> 
<223> CD28 cytoplasmic domain

<400> 118
cgcagcaagc ggagcagagg cggccacagc gactacatga acatgacccc tagacggcct 60
ggccccacca gaaagcacta ccagccctac gcccctcccc gggactttgc cgcctacaga 120
agc                                                               123

<210> 119
<211> 41
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD28 cytoplasmic domain

<400> 119
Arg Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr
 1               5                  10                  15      
Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
            20                  25                  30          
Pro Arg Asp Phe Ala Ala Tyr Arg Ser
        35                  40      



<210> 120
<211> 46
<212> DNA
<213> Artificial Sequence

<220> 
<223> DNA spacer

<400> 120
gctagcgttt aaacttaagc ttggtaccga gctcggatcc gccacc                46



<210> 121
<211> 862
<212> PRT
<213> Artificial Sequence

<220> 
<223> HEA3(p65/S536E/K310Q) amino acid sequence variant

<400> 121
Met Val Ser Lys Leu Ser Gln Leu Gln Thr Glu Leu Leu Ala Ala Leu
 1               5                  10                  15      
Leu Glu Ser Gly Leu Ser Lys Glu Ala Leu Ile Gln Ala Leu Gly Glu
            20                  25                  30          
Pro Gly Pro Tyr Leu Leu Ala Gly Glu Gly Pro Leu Asp Lys Gly Glu
        35                  40                  45              
Ser Cys Gly Gly Gly Arg Gly Glu Leu Ala Glu Leu Pro Asn Gly Leu
    50                  55                  60                  
Gly Glu Thr Arg Gly Ser Glu Asp Glu Thr Asp Asp Asp Gly Glu Asp
65                  70                  75                  80  
Phe Thr Pro Pro Ile Leu Lys Glu Leu Glu Asn Leu Ser Pro Glu Glu
                85                  90                  95      
Ala Ala His Gln Lys Ala Val Val Glu Thr Leu Leu Gln Glu Asp Pro
            100                 105                 110         
Trp Arg Val Ala Lys Met Val Lys Ser Tyr Leu Gln Gln His Asn Ile
        115                 120                 125             
Pro Gln Arg Glu Val Val Asp Thr Thr Gly Leu Asn Gln Ser His Leu
    130                 135                 140                 
Ser Gln His Leu Asn Lys Gly Thr Pro Met Lys Thr Gln Lys Arg Ala
145                 150                 155                 160 
Ala Leu Tyr Thr Trp Tyr Val Arg Lys Gln Arg Glu Val Ala Gln Gln
                165                 170                 175     
Phe Thr His Ala Gly Gln Gly Gly Leu Ile Glu Glu Pro Thr Gly Asp
            180                 185                 190         
Glu Leu Pro Thr Lys Lys Gly Arg Arg Asn Arg Phe Lys Trp Gly Pro
        195                 200                 205             
Ala Ser Gln Gln Ile Leu Phe Gln Ala Tyr Glu Arg Gln Lys Asn Pro
    210                 215                 220                 
Ser Lys Glu Glu Arg Glu Thr Leu Val Glu Glu Cys Asn Arg Ala Glu
225                 230                 235                 240 
Cys Ile Gln Arg Gly Val Ser Pro Ser Gln Ala Gln Gly Leu Gly Ser
                245                 250                 255     
Asn Leu Val Thr Glu Val Arg Val Tyr Asn Trp Phe Ala Asn Arg Arg
            260                 265                 270         
Lys Glu Glu Ala Phe Arg His Lys Leu Ser Ala Gly Asp Met Arg Ala
        275                 280                 285             
Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn
    290                 295                 300                 
Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu
305                 310                 315                 320 
Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro
                325                 330                 335     
Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg
            340                 345                 350         
Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val
        355                 360                 365             
Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu
    370                 375                 380                 
Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly
385                 390                 395                 400 
Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys
                405                 410                 415     
Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser
            420                 425                 430         
Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu
        435                 440                 445             
Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser
    450                 455                 460                 
Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp
465                 470                 475                 480 
Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr
                485                 490                 495     
Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser
            500                 505                 510         
His Ile Arg His Met Ser Asn Lys Arg Met Glu His Leu Tyr Ser Met
        515                 520                 525             
Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu
    530                 535                 540                 
Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val
545                 550                 555                 560 
Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser
                565                 570                 575     
His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro
            580                 585                 590         
Ala Thr Val Glu Phe Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg
        595                 600                 605             
Ile Glu Glu Lys Arg Lys Arg Thr Tyr Glu Thr Phe Gln Ser Ile Met
    610                 615                 620                 
Lys Lys Ser Pro Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg
625                 630                 635                 640 
Arg Ile Ala Val Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala
                645                 650                 655     
Pro Gln Pro Tyr Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp
            660                 665                 670         
Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser
        675                 680                 685             
Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro
    690                 695                 700                 
Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro
705                 710                 715                 720 
Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala
                725                 730                 735     
Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu
            740                 745                 750         
Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser
        755                 760                 765             
Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu
    770                 775                 780                 
Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr
785                 790                 795                 800 
Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr
                805                 810                 815     
Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro
            820                 825                 830         
Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Glu Ser Ile
        835                 840                 845             
Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser
    850                 855                 860         


<210> 122
<211> 2586
<212> DNA
<213> Artificial Sequence

<220> 
<223> HEA3(p65/S536E/K310Q) variant nucleotide sequence

<400> 122
atggtgtcca agctgtccca gctgcagaca gaactgctgg cagcactgct ggaaagcggc 60
ctgagcaaag aggccctgat tcaggcactc ggcgaacctg gaccttatct gctcgctggc 120
gaaggccctc tggataaggg cgagagctgt ggcggaggaa gaggagagct ggccgagctg 180
cctaacggcc tgggcgagac aagaggcagc gaggacgaga cagacgacga cggcgaggac 240
ttcacccccc ccatcctgaa agagctggaa aacctgagcc ccgaggaagc cgcccaccag 300
aaagccgtgg tggagacact gctgcaggaa gatccctggc gggtcgccaa gatggtcaag 360
agctacctgc agcagcacaa catcccccag cgggaggtgg tggacaccac cggcctgaac 420
cagagccacc tgagccagca cctgaacaag ggcaccccca tgaaaaccca gaagagagcc 480
gccctgtaca cttggtacgt gcggaagcag agagaggtgg cccagcagtt tacacacgcc 540
ggccagggcg gcctgatcga ggaacctacc ggcgacgagc tgcccaccaa gaagggcaga 600
cggaaccggt ttaagtgggg ccctgcatct cagcagatcc tgttccaggc ctacgagcgg 660
cagaagaacc ccagcaaaga ggaacgggag acactggtgg aagagtgcaa ccgggccgag 720
tgcatccaga gaggcgtgag cccttctcag gctcagggcc tcggcagcaa tctggtcacc 780
gaagtgcggg tgtacaattg gttcgccaac cggcggaaag aggaagcctt ccggcacaag 840
ctgtctgctg gcgatatgag agccgccaac ctgtggccca gccccctgat gatcaagcgg 900
agcaagaaga acagcctggc cctgagcctg accgccgatc agatggtgtc cgctctgctg 960
gacgccgagc cccctatcct gtacagcgag tacgacccca ccagaccctt cagcgaggcc 1020
agcatgatgg gcctgctgac caacctggcc gaccgggagc tggtgcacat gatcaactgg 1080
gccaagcggg tgcccggctt cgtggacctg accctgcacg accaggtcca cctgctggaa 1140
tgtgcctggc tggaaatcct gatgatcggc ctcgtgtgga gaagcatgga acaccccggc 1200
aagctgctgt tcgcccccaa cctgctcctg gaccggaacc agggaaagtg cgtggagggc 1260
atggtggaga tcttcgacat gctgctggcc acctccagcc ggttccggat gatgaacctg 1320
cagggcgagg aattcgtgtg cctgaagtcc atcatcctgc tgaacagcgg cgtgtacacc 1380
ttcctgtcat ccaccctgaa gtccctggaa gagaaggacc acatccaccg ggtgctggac 1440
aagatcaccg acaccctgat ccacctgatg gccaaggctg gcctgacact ccagcagcag 1500
caccagagac tggcccagct gctgctgatc ctgagccaca tccggcacat gagcaacaag 1560
cggatggaac acctgtacag catgaagtgc aagaacgtgg tgcccctgta cgacctgctg 1620
ctcgagatgc tggatgccca cagactgcac gcccctacaa gcagaggcgg agccagcgtg 1680
gaggaaaccg accagtctca cctggccacc gccggcagca caagcagcca cagcctgcag 1740
aagtactaca tcaccggcga ggccgaggga ttccctgcca ccgtggagtt ccagtacctg 1800
cccgacaccg acgaccggca ccggatcgag gaaaagcgga agcggaccta cgagacattc 1860
cagagcatca tgaagaagtc ccccttcagc ggccccaccg atcccagacc cccccctaga 1920
agaatcgccg tgcccagcag atctagcgcc agcgtgccca agcctgcccc ccagccctac 1980
cctttcacca gcagcctgag caccatcaac tacgacgagt tccctaccat ggtgttcccc 2040
agcggccaga tctctcaggc ctctgctctg gcacctgctc cacctcaggt gctgcctcag 2100
gcccctgctc cagccccagc ccctgccatg gtgtctgcac tggcccaggc tccagctcct 2160
gtgcctgtgc tggcccctgg acctcctcag gctgtggccc ctcctgcccc taaacctacc 2220
caggccgggg agggaacact gtctgaggcc ctgctgcagc tccagttcga cgacgaggat 2280
ctgggagcac tgctgggcaa tagcaccgac cccgccgtgt ttaccgacct ggcctccgtg 2340
gacaacagcg agttccagca gctcctcaac cagggcatcc ctgtcgcccc acacaccacc 2400
gagcccatgc tgatggaata ccccgaggcc atcaccagac tggtcacagg cgcccagagg 2460
cctccagatc cagcaccagc tccactggga gcccctggcc tgcctaatgg gctgctgtct 2520
ggcgacgagg acttcgagag cattgccgac atggacttca gcgccctgct gtcccagatc 2580
agcagc                                                            2586

<210> 123
<211> 142
<212> PRT
<213> Artificial Sequence

<220> 
<223> Survivin amino acid sequence

<400> 123
Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp
 1               5                  10                  15      
His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala
            20                  25                  30          
Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr
        35                  40                  45              
Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu
    50                  55                  60                  
Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Glu Glu His Lys Lys His
65                  70                  75                  80  
Ser Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu
                85                  90                  95      
Thr Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn Lys
            100                 105                 110         
Ile Ala Lys Glu Thr Asn Asn Lys Lys Lys Glu Phe Glu Glu Thr Val
        115                 120                 125             
Lys Lys Val Arg Arg Ala Ile Glu Gln Leu Ala Ala Met Asp
    130                 135                 140         


<210> 124
<211> 426
<212> DNA
<213> Artificial Sequence

<220> 
<223> Survivin nucleotide sequence

<400> 124
atgggtgccc cgacgttgcc ccctgcctgg cagccctttc tcaaggacca ccgcatctct 60
acattcaaga actggccctt cttggagggc tgcgcctgca ccccggagcg gatggccgag 120
gctggcttca tccactgccc cactgagaac gagccagact tggcccagtg tttcttctgc 180
ttcaaggagc tggaaggctg ggagccagat gacgacccca tagaggaaca taaaaagcat 240
tcgtccggtt gcgctttcct ttctgtcaag aagcagtttg aagaattaac ccttggtgaa 300
tttttgaaac tggacagaga aagagccaag aacaaaattg caaaggaaac caacaataag 360
aagaaagaat ttgaggaaac tgtgaagaaa gtgcgccgtg ccatcgagca gctggctgca 420
atggat                                                            426

