                         SEQUENCE LISTING

<110>  Merck Sharp & Dohme Corp.
       Beijing Genomics Institute at Shenzhen
       Shaw, Peter M.
       Mehrotra, Devan V.
       Blanchard, Rebecca L.
       Shen, Judong
       Mogg, Robin
       Dorr, Mary Beth
       Li, Junhua
       Xu, Xun
 
<120>  HUMAN GENETIC MARKERS ASSOCIATED WITH RESPONSE TO TREATMENTS THAT 
       TARGET CLOSTRIDIUM DIFFICILE TOXIN  B

<130>  24383-WO-PCT-2

<150>	62/508,066
<151>	05/18/2017

<150>	PCT/CN2016/109900
<151>	12/14/2016

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  1

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Thr 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  2
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  2

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu 
1               5                   10      


<210>  3
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  4
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Gln Tyr Gly Ser Ser Thr Trp Thr 
1               5                   


<210>  5
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Ser Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Phe Tyr Pro Gly Asp Ser Ser Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Val Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Asn Trp Gly Asn Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  6
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Tyr Trp Ile Gly 
1               5   


<210>  7
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  7

Ile Phe Tyr Pro Gly Asp Ser Ser Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  8

Arg Arg Asn Trp Gly Asn Ala Phe Asp Ile 
1               5                   10  


<210>  9
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  10
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  10

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln Gln Ala Asn Ser Phe Pro Trp Thr 
1               5                   


<210>  13
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  13

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Trp Tyr Asp Gly Ser Asn Glu Asp Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Met Val Arg Gly Val Ile Asp Val Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Val Val Thr Val Ser Ser 
        115                 120         


<210>  14
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  14

Asn Tyr Gly Met His 
1               5   


<210>  15
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  15

Leu Ile Trp Tyr Asp Gly Ser Asn Glu Asp Tyr Thr Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  16
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  16

Trp Gly Met Val Arg Gly Val Ile Asp Val Phe Asp Ile 
1               5                   10              


<210>  17
<211>  32
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  N= T or C

<400>  17
ttcaaatctc tgctcntcat ttcacaccat ct                                     32


<210>  18
<211>  33
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  N= A or G

<400>  18
agatggtgtg aaatgangag cagagatttg aaa                                    33


<210>  19
<211>  51
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  N= A or C

<400>  19
tgtctttcaa aactctgatt tgaggnatgt tggacctccc tttctatctt c                51


<210>  20
<211>  51
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  N= T or G

<400>  20
gaagatagaa agggaggtcc aacatncctc aaatcagagt tttgaaagac a                51


<210>  21
<211>  51
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  N= A or G

<400>  21
cgggaggtcg aggctgcagt gagccntcat tgcaccattg cactccagcc t                51


<210>  22
<211>  51
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  N= T or C

<400>  22
aggctggagt gcaatggtgc aatganggct cactgcagcc tcgacctccc g                51


