                         SEQUENCE LISTING

<110>  Bartorelli Cusani, Alberto
 
<120>  NOVEL RECOMBINANT PROTEIN UK 114 IN STABLE POLYMER FORM FOR USE 
       IN THE TREATMENT, DIAGNOSIS AND PREVENTION OF MALIGNANT SOLID 
       AND SYSTEMIC TUMOURS

<130>  1734PCT

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  140
<212>  PRT
<213>  Capra hircus

<400>  1

Gly Ser His Met Ser Ser Leu Val Arg Arg Ile Ile Ser Thr Ala Lys 
1               5                   10                  15      


Ala Pro Ala Ala Ile Gly Pro Tyr Ser Gln Ala Val Leu Val Asp Arg 
            20                  25                  30          


Thr Ile Tyr Ile Ser Gly Gln Leu Gly Met Asp Pro Ala Ser Gly Gln 
        35                  40                  45              


Leu Val Pro Gly Gly Val Val Glu Glu Ala Lys Gln Ala Leu Thr Asn 
    50                  55                  60                  


Ile Gly Glu Ile Leu Lys Ala Ala Gly Cys Asp Phe Thr Asn Val Val 
65                  70                  75                  80  


Lys Ala Thr Val Leu Leu Ala Asp Ile Asn Asp Phe Ser Ala Val Asn 
                85                  90                  95      


Asp Val Tyr Lys Gln Tyr Phe Gln Ser Ser Phe Pro Ala Arg Ala Ala 
            100                 105                 110         


Tyr Gln Val Ala Ala Leu Pro Lys Gly Gly Arg Val Glu Ile Glu Ala 
        115                 120                 125             


Ile Ala Val Gln Gly Pro Leu Thr Thr Ala Ser Leu 
    130                 135                 140 


<210>  2
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic primer

<400>  2
agcatattcg actgacatat gtcgtctttg gtcagaagga t                           41


<210>  3
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  3
atcgtcgggc tcactcgagc tagagtgatg ctgtcgtgag a                           41


<210>  4
<211>  474
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  expression vector

<400>  4
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat       60

atgtcgtctt tggtcagaag gataatcagc acggcgaaag cccccgcggc cattggtccc      120

tacagtcagg ctgtgttagt cgacaggacc atttacattt caggacagct aggtatggac      180

cctgcaagtg gacagcttgt gccaggaggg gtggtagaag aggctaaaca ggctcttaca      240

aacataggtg aaattctgaa agcagcaggc tgtgacttca cgaatgtggt aaaagcaacg      300

gttttgctgg ctgacataaa tgacttcagt gctgtcaatg atgtctacaa acaatatttc      360

cagagtagtt ttccggcgag agctgcttac caggttgctg ctttgcccaa aggaggccgt      420

gttgagatcg aagcaatagc tgtgcaagga cctctcacga cagcatcact ctaa            474


<210>  5
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-tag-fusion protein

<400>  5

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Ser Leu Val Arg Arg Ile Ile Ser Thr Ala 
            20                  25                  30          


Lys Ala Pro Ala Ala Ile Gly Pro Tyr Ser Gln Ala Val Leu Val Asp 
        35                  40                  45              


Arg Thr Ile Tyr Ile Ser Gly Gln Leu Gly Met Asp Pro Ala Ser Gly 
    50                  55                  60                  


Gln Leu Val Pro Gly Gly Val Val Glu Glu Ala Lys Gln Ala Leu Thr 
65                  70                  75                  80  


Asn Ile Gly Glu Ile Leu Lys Ala Ala Gly Cys Asp Phe Thr Asn Val 
                85                  90                  95      


Val Lys Ala Thr Val Leu Leu Ala Asp Ile Asn Asp Phe Ser Ala Val 
            100                 105                 110         


Asn Asp Val Tyr Lys Gln Tyr Phe Gln Ser Ser Phe Pro Ala Arg Ala 
        115                 120                 125             


Ala Tyr Gln Val Ala Ala Leu Pro Lys Gly Gly Arg Val Glu Ile Glu 
    130                 135                 140                 


Ala Ile Ala Val Gln Gly Pro Leu Thr Thr Ala Ser Leu 
145                 150                 155         


<210>  6
<211>  139
<212>  PRT
<213>  Capra hircus

<400>  6

Val Pro Met Ser Ser Leu Val Arg Arg Ile Ile Ser Thr Ala Lys Ala 
1               5                   10                  15      


Pro Ala Ala Ile Gly Pro Tyr Ser Gln Ala Val Leu Val Asp Arg Thr 
            20                  25                  30          


Ile Tyr Ile Ser Gly Gln Leu Gly Met Asp Pro Ala Ser Gly Gln Leu 
        35                  40                  45              


Val Pro Gly Gly Val Val Glu Glu Ala Lys Gln Ala Leu Thr Asn Ile 
    50                  55                  60                  


Gly Glu Ile Leu Lys Ala Ala Gly Cys Asp Phe Thr Asn Val Val Lys 
65                  70                  75                  80  


Ala Thr Val Leu Leu Ala Asp Ile Asn Asp Phe Ser Ala Val Asn Asp 
                85                  90                  95      


Val Tyr Lys Gln Tyr Phe Gln Ser Ser Phe Pro Ala Arg Ala Ala Tyr 
            100                 105                 110         


Gln Val Ala Ala Leu Pro Lys Gly Gly Arg Val Glu Ile Glu Ala Ile 
        115                 120                 125             


Ala Val Gln Gly Pro Leu Thr Thr Ala Ser Leu 
    130                 135                 


<210>  7
<211>  137
<212>  PRT
<213>  Capra hircus

<400>  7

Met Ser Ser Leu Val Arg Arg Ile Ile Ser Thr Ala Lys Ala Pro Ala 
1               5                   10                  15      


Ala Ile Gly Pro Tyr Ser Gln Ala Val Leu Val Asp Arg Thr Ile Tyr 
            20                  25                  30          


Ile Ser Gly Gln Leu Gly Met Asp Pro Ala Ser Gly Gln Leu Val Pro 
        35                  40                  45              


Gly Gly Val Val Glu Glu Ala Lys Gln Ala Leu Thr Asn Ile Gly Glu 
    50                  55                  60                  


Ile Leu Lys Ala Ala Gly Cys Asp Phe Thr Asn Val Val Lys Ala Thr 
65                  70                  75                  80  


Val Leu Leu Ala Asp Ile Asn Asp Phe Ser Ala Val Asn Asp Val Tyr 
                85                  90                  95      


Lys Gln Tyr Phe Gln Ser Ser Phe Pro Ala Arg Ala Ala Tyr Gln Val 
            100                 105                 110         


Ala Ala Leu Pro Lys Gly Gly Arg Val Glu Ile Glu Ala Ile Ala Val 
        115                 120                 125             


Gln Gly Pro Leu Thr Thr Ala Ser Leu 
    130                 135         


<210>  8
<211>  139
<212>  PRT
<213>  Capra hircus

<400>  8

Val Pro Met Ser Ser Leu Val Arg Arg Ile Ile Ser Thr Ala Lys Ala 
1               5                   10                  15      


Pro Ala Ala Ile Gly Pro Tyr Ser Gln Ala Val Leu Val Asp Arg Thr 
            20                  25                  30          


Ile Tyr Ile Ser Gly Gln Leu Gly Met Asp Pro Ala Ser Gly Gln Leu 
        35                  40                  45              


Val Pro Gly Gly Val Val Glu Glu Ala Lys Gln Ala Leu Thr Asn Ile 
    50                  55                  60                  


Gly Glu Ile Leu Lys Ala Ala Gly Cys Asp Phe Thr Asn Val Val Lys 
65                  70                  75                  80  


Ala Thr Val Leu Leu Ala Asp Ile Asn Asp Phe Ser Ala Val Asn Asp 
                85                  90                  95      


Val Tyr Lys Gln Tyr Phe Gln Ser Ser Phe Pro Ala Arg Ala Ala Tyr 
            100                 105                 110         


Gln Val Ala Ala Leu Pro Lys Gly Gly Arg Val Glu Ile Glu Ala Ile 
        115                 120                 125             


Ala Val Gln Gly Pro Leu Thr Thr Ala Ser Val 
    130                 135                 


