                         SEQUENCE LISTING

<110>  йѧԺϺ˹о
 
<120>  ѪѭϸϵӦ

<130>  C17W0487

<150>  201611154224.3
<151>  2016-12-14

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  928
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V2C

<400>  1

Met Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
1               5                   10                  15      


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
            20                  25                  30          


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
        35                  40                  45              


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
    50                  55                  60                  


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
65                  70                  75                  80  


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
                85                  90                  95      


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
            100                 105                 110         


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
        115                 120                 125             


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
    130                 135                 140                 


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
145                 150                 155                 160 


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
                165                 170                 175     


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly Trp 
            180                 185                 190         


Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
        195                 200                 205             


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
    210                 215                 220                 


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
225                 230                 235                 240 


Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu Cys 
                245                 250                 255     


Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser Thr 
            260                 265                 270         


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
        275                 280                 285             


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Gln Gln 
    290                 295                 300                 


Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
305                 310                 315                 320 


Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser Ser Leu Glu 
                325                 330                 335     


Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys Leu 
            340                 345                 350         


Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Glu Lys Ile 
        355                 360                 365             


Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Gly Ile Ala 
    370                 375                 380                 


Ser Val Glu Gln Glu Gln Ile Ser Asp Pro Ser Ser Asn Lys Thr Cys 
385                 390                 395                 400 


Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys Lys His 
                405                 410                 415     


Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Arg Val Cys Val 
            420                 425                 430         


Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn Cys Cys Cys Gln Asp 
        435                 440                 445             


Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Ser Gly Ser 
    450                 455                 460                 


Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
465                 470                 475                 480 


Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Cys Tyr Lys Cys Asp 
                485                 490                 495     


Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn Trp Ile Trp 
            500                 505                 510         


Lys Lys Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr Ala Asn 
        515                 520                 525             


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Val Cys 
    530                 535                 540                 


Leu Asp Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg Thr 
545                 550                 555                 560 


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
                565                 570                 575     


Lys Asn Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys 
            580                 585                 590         


Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu 
        595                 600                 605             


Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu 
    610                 615                 620                 


Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys 
625                 630                 635                 640 


Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp Glu 
                645                 650                 655     


Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala 
            660                 665                 670         


Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Cys Gly Asp Gly 
        675                 680                 685             


Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile Asp 
    690                 695                 700                 


Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe 
705                 710                 715                 720 


Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Glu Asn Cys Lys 
                725                 730                 735     


Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr Glu 
            740                 745                 750         


Cys Lys Asn Lys Cys Glu Val Tyr Lys Lys Phe Ile Glu Asp Cys Lys 
        755                 760                 765             


Gly Gly Asp Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp Gln 
    770                 775                 780                 


Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg 
785                 790                 795                 800 


Lys Ala Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Asn Ala Ala 
                805                 810                 815     


Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu 
            820                 825                 830         


Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu 
        835                 840                 845             


Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr 
    850                 855                 860                 


Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp Lys Ser Lys 
865                 870                 875                 880 


Leu Gln Gln Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu 
                885                 890                 895     


Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys Lys Ile Pro 
            900                 905                 910         


Thr Asn His His His His His His Leu Glu His His His His His His 
        915                 920                 925             


<210>  2
<211>  2016
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V2C-lacZںϵ

<400>  2

Met Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
1               5                   10                  15      


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
            20                  25                  30          


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
        35                  40                  45              


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
    50                  55                  60                  


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
65                  70                  75                  80  


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
                85                  90                  95      


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
            100                 105                 110         


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
        115                 120                 125             


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
    130                 135                 140                 


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
145                 150                 155                 160 


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
                165                 170                 175     


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly Trp 
            180                 185                 190         


Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
        195                 200                 205             


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
    210                 215                 220                 


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
225                 230                 235                 240 


Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu Cys 
                245                 250                 255     


Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser Thr 
            260                 265                 270         


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
        275                 280                 285             


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Gln Gln 
    290                 295                 300                 


Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
305                 310                 315                 320 


Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser Ser Leu Glu 
                325                 330                 335     


Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys Leu 
            340                 345                 350         


Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Glu Lys Ile 
        355                 360                 365             


Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Gly Ile Ala 
    370                 375                 380                 


Ser Val Glu Gln Glu Gln Ile Ser Asp Pro Ser Ser Asn Lys Thr Cys 
385                 390                 395                 400 


Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys Lys His 
                405                 410                 415     


Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Arg Val Cys Val 
            420                 425                 430         


Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn Cys Cys Cys Gln Asp 
        435                 440                 445             


Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Ser Gly Ser 
    450                 455                 460                 


Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
465                 470                 475                 480 


Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Cys Tyr Lys Cys Asp 
                485                 490                 495     


Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn Trp Ile Trp 
            500                 505                 510         


Lys Lys Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr Ala Asn 
        515                 520                 525             


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Val Cys 
    530                 535                 540                 


Leu Asp Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg Thr 
545                 550                 555                 560 


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
                565                 570                 575     


Lys Asn Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys 
            580                 585                 590         


Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu 
        595                 600                 605             


Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu 
    610                 615                 620                 


Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys 
625                 630                 635                 640 


Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp Glu 
                645                 650                 655     


Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala 
            660                 665                 670         


Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Cys Gly Asp Gly 
        675                 680                 685             


Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile Asp 
    690                 695                 700                 


Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe 
705                 710                 715                 720 


Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Glu Asn Cys Lys 
                725                 730                 735     


Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr Glu 
            740                 745                 750         


Cys Lys Asn Lys Cys Glu Val Tyr Lys Lys Phe Ile Glu Asp Cys Lys 
        755                 760                 765             


Gly Gly Asp Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp Gln 
    770                 775                 780                 


Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg 
785                 790                 795                 800 


Lys Ala Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Asn Ala Ala 
                805                 810                 815     


Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu 
            820                 825                 830         


Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu 
        835                 840                 845             


Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr 
    850                 855                 860                 


Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp Lys Ser Lys 
865                 870                 875                 880 


Leu Gln Gln Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu 
                885                 890                 895     


Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys Lys Ile Pro 
            900                 905                 910         


Thr Asn Gly Ser Gly Ser Gly Gly Met Glu Val His Thr Asn Gln Asp 
        915                 920                 925             


Pro Leu Asp Val Asp Glu Val His Thr Asn Gln Asp Pro Leu Asp Gly 
    930                 935                 940                 


Thr Glu Val His Thr Asn Gln Asp Pro Leu Asp Glu Phe Asp Tyr Lys 
945                 950                 955                 960 


Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp 
                965                 970                 975     


Asp Asp Lys Gly Ser Ile Thr Asp Ser Leu Ala Val Val Leu Gln Arg 
            980                 985                 990         


Arg Asp Trp Glu Asn Pro Gly Val  Thr Gln Leu Asn Arg  Leu Ala Ala 
        995                 1000                 1005             


His Pro  Pro Phe Ala Ser Trp  Arg Asn Ser Glu Glu  Ala Arg Thr 
    1010                 1015                 1020             


Asp Arg  Pro Ser Gln Gln Leu  Arg Ser Leu Asn Gly  Glu Trp Arg 
    1025                 1030                 1035             


Phe Ala  Trp Phe Pro Ala Pro  Glu Ala Val Pro Glu  Ser Trp Leu 
    1040                 1045                 1050             


Glu Cys  Asp Leu Pro Glu Ala  Asp Thr Val Val Val  Pro Ser Asn 
    1055                 1060                 1065             


Trp Gln  Met His Gly Tyr Asp  Ala Pro Ile Tyr Thr  Asn Val Thr 
    1070                 1075                 1080             


Tyr Pro  Ile Thr Val Asn Pro  Pro Phe Val Pro Thr  Glu Asn Pro 
    1085                 1090                 1095             


Thr Gly  Cys Tyr Ser Leu Thr  Phe Asn Val Asp Glu  Ser Trp Leu 
    1100                 1105                 1110             


Gln Glu  Gly Gln Thr Arg Ile  Ile Phe Asp Gly Val  Asn Ser Ala 
    1115                 1120                 1125             


Phe His  Leu Trp Cys Asn Gly  Arg Trp Val Gly Tyr  Gly Gln Asp 
    1130                 1135                 1140             


Ser Arg  Leu Pro Ser Glu Phe  Asp Leu Ser Ala Phe  Leu Arg Ala 
    1145                 1150                 1155             


Gly Glu  Asn Arg Leu Ala Val  Met Val Leu Arg Trp  Ser Asp Gly 
    1160                 1165                 1170             


Ser Tyr  Leu Glu Asp Gln Asp  Met Trp Arg Met Ser  Gly Ile Phe 
    1175                 1180                 1185             


Arg Asp  Val Ser Leu Leu His  Lys Pro Thr Thr Gln  Ile Ser Asp 
    1190                 1195                 1200             


Phe His  Val Ala Thr Arg Phe  Asn Asp Asp Phe Ser  Arg Ala Val 
    1205                 1210                 1215             


Leu Glu  Ala Glu Val Gln Met  Cys Gly Glu Leu Arg  Asp Tyr Leu 
    1220                 1225                 1230             


Arg Val  Thr Val Ser Leu Trp  Gln Gly Glu Thr Gln  Val Ala Ser 
    1235                 1240                 1245             


Gly Thr  Ala Pro Phe Gly Gly  Glu Ile Ile Asp Glu  Arg Gly Gly 
    1250                 1255                 1260             


Tyr Ala  Asp Arg Val Thr Leu  Arg Leu Asn Val Glu  Asn Pro Lys 
    1265                 1270                 1275             


Leu Trp  Ser Ala Glu Ile Pro  Asn Leu Tyr Arg Ala  Val Val Glu 
    1280                 1285                 1290             


Leu His  Thr Ala Asp Gly Thr  Leu Ile Glu Ala Glu  Ala Cys Asp 
    1295                 1300                 1305             


Val Gly  Phe Arg Glu Val Arg  Ile Glu Asn Gly Leu  Leu Leu Leu 
    1310                 1315                 1320             


Asn Gly  Lys Pro Leu Leu Ile  Arg Gly Val Asn Arg  His Glu His 
    1325                 1330                 1335             


His Pro  Leu His Gly Gln Val  Met Asp Glu Gln Thr  Met Val Gln 
    1340                 1345                 1350             


Asp Ile  Leu Leu Met Lys Gln  Asn Asn Phe Asn Ala  Val Arg Cys 
    1355                 1360                 1365             


Ser His  Tyr Pro Asn His Pro  Leu Trp Tyr Thr Leu  Cys Asp Arg 
    1370                 1375                 1380             


Tyr Gly  Leu Tyr Val Val Asp  Glu Ala Asn Ile Glu  Thr His Gly 
    1385                 1390                 1395             


Met Val  Pro Met Asn Arg Leu  Thr Asp Asp Pro Arg  Trp Leu Pro 
    1400                 1405                 1410             


Ala Met  Ser Glu Arg Val Thr  Arg Met Val Gln Arg  Asp Arg Asn 
    1415                 1420                 1425             


His Pro  Ser Val Ile Ile Trp  Ser Leu Gly Asn Glu  Ser Gly His 
    1430                 1435                 1440             


Gly Ala  Asn His Asp Ala Leu  Tyr Arg Trp Ile Lys  Ser Val Asp 
    1445                 1450                 1455             


Pro Ser  Arg Pro Val Gln Tyr  Glu Gly Gly Gly Ala  Asp Thr Thr 
    1460                 1465                 1470             


Ala Thr  Asp Ile Ile Cys Pro  Met Tyr Ala Arg Val  Asp Glu Asp 
    1475                 1480                 1485             


Gln Pro  Phe Pro Ala Val Pro  Lys Trp Ser Ile Lys  Lys Trp Leu 
    1490                 1495                 1500             


Ser Leu  Pro Gly Glu Thr Arg  Pro Leu Ile Leu Cys  Glu Tyr Ala 
    1505                 1510                 1515             


His Ala  Met Gly Asn Ser Leu  Gly Gly Phe Ala Lys  Tyr Trp Gln 
    1520                 1525                 1530             


Ala Phe  Arg Gln Tyr Pro Arg  Leu Gln Gly Gly Phe  Val Trp Asp 
    1535                 1540                 1545             


Trp Val  Asp Gln Ser Leu Ile  Lys Tyr Asp Glu Asn  Gly Asn Pro 
    1550                 1555                 1560             


Trp Ser  Ala Tyr Gly Gly Asp  Phe Gly Asp Thr Pro  Asn Asp Arg 
    1565                 1570                 1575             


Gln Phe  Cys Met Asn Gly Leu  Val Phe Ala Asp Arg  Thr Pro His 
    1580                 1585                 1590             


Pro Ala  Leu Thr Glu Ala Lys  His Gln Gln Gln Phe  Phe Gln Phe 
    1595                 1600                 1605             


Arg Leu  Ser Gly Gln Thr Ile  Glu Val Thr Ser Glu  Tyr Leu Phe 
    1610                 1615                 1620             


Arg His  Ser Asp Asn Glu Leu  Leu His Trp Met Val  Ala Leu Asp 
    1625                 1630                 1635             


Gly Lys  Pro Leu Ala Ser Gly  Glu Val Pro Leu Asp  Val Ala Pro 
    1640                 1645                 1650             


Gln Gly  Lys Gln Leu Ile Glu  Leu Pro Glu Leu Pro  Gln Pro Glu 
    1655                 1660                 1665             


Ser Ala  Gly Gln Leu Trp Leu  Thr Val Arg Val Val  Gln Pro Asn 
    1670                 1675                 1680             


Ala Thr  Ala Trp Ser Glu Ala  Gly His Ile Ser Ala  Trp Gln Gln 
    1685                 1690                 1695             


Trp Arg  Leu Ala Glu Asn Leu  Ser Val Thr Leu Pro  Ala Ala Ser 
    1700                 1705                 1710             


His Ala  Ile Pro His Leu Thr  Thr Ser Glu Met Asp  Phe Cys Ile 
    1715                 1720                 1725             


Glu Leu  Gly Asn Lys Arg Trp  Gln Phe Asn Arg Gln  Ser Gly Phe 
    1730                 1735                 1740             


Leu Ser  Gln Met Trp Ile Gly  Asp Lys Lys Gln Leu  Leu Thr Pro 
    1745                 1750                 1755             


Leu Arg  Asp Gln Phe Thr Arg  Ala Pro Leu Asp Asn  Asp Ile Gly 
    1760                 1765                 1770             


Val Ser  Glu Ala Thr Arg Ile  Asp Pro Asn Ala Trp  Val Glu Arg 
    1775                 1780                 1785             


Trp Lys  Ala Ala Gly His Tyr  Gln Ala Glu Ala Ala  Leu Leu Gln 
    1790                 1795                 1800             


Cys Thr  Ala Asp Thr Leu Ala  Asp Ala Val Leu Ile  Thr Thr Ala 
    1805                 1810                 1815             


His Ala  Trp Gln His Gln Gly  Lys Thr Leu Phe Ile  Ser Arg Lys 
    1820                 1825                 1830             


Thr Tyr  Arg Ile Asp Gly Ser  Gly Gln Met Ala Ile  Thr Val Asp 
    1835                 1840                 1845             


Val Glu  Val Ala Ser Asp Thr  Pro His Pro Ala Arg  Ile Gly Leu 
    1850                 1855                 1860             


Asn Cys  Gln Leu Ala Gln Val  Ala Glu Arg Val Asn  Trp Leu Gly 
    1865                 1870                 1875             


Leu Gly  Pro Gln Glu Asn Tyr  Pro Asp Arg Leu Thr  Ala Ala Cys 
    1880                 1885                 1890             


Phe Asp  Arg Trp Asp Leu Pro  Leu Ser Asp Met Tyr  Thr Pro Tyr 
    1895                 1900                 1905             


Val Phe  Pro Ser Glu Asn Gly  Leu Arg Cys Gly Thr  Arg Glu Leu 
    1910                 1915                 1920             


Asn Tyr  Gly Pro His Gln Trp  Arg Gly Asp Phe Gln  Phe Asn Ile 
    1925                 1930                 1935             


Ser Arg  Tyr Ser Gln Gln Gln  Leu Met Glu Thr Ser  His Arg His 
    1940                 1945                 1950             


Leu Leu  His Ala Glu Glu Gly  Thr Trp Leu Asn Ile  Asp Gly Phe 
    1955                 1960                 1965             


His Met  Gly Ile Gly Gly Asp  Asp Ser Trp Ser Pro  Ser Val Ser 
    1970                 1975                 1980             


Ala Glu  Phe Gln Leu Ser Ala  Gly Arg Tyr His Tyr  Gln Leu Val 
    1985                 1990                 1995             


Trp Cys  Gln Lys His His His  His His His Leu Glu  His His His 
    2000                 2005                 2010             


His His  His 
    2015     


<210>  3
<211>  930
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V2Cױ

<400>  3

Met Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
1               5                   10                  15      


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
            20                  25                  30          


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
        35                  40                  45              


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
    50                  55                  60                  


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
65                  70                  75                  80  


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
                85                  90                  95      


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
            100                 105                 110         


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
        115                 120                 125             


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
    130                 135                 140                 


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
145                 150                 155                 160 


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
                165                 170                 175     


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly Trp 
            180                 185                 190         


Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
        195                 200                 205             


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
    210                 215                 220                 


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
225                 230                 235                 240 


Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu Cys 
                245                 250                 255     


Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser Thr 
            260                 265                 270         


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
        275                 280                 285             


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Gln Gln 
    290                 295                 300                 


Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
305                 310                 315                 320 


Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser Ser Leu Glu 
                325                 330                 335     


Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys Leu 
            340                 345                 350         


Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Glu Lys Ile 
        355                 360                 365             


Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Gly Ile Ala 
    370                 375                 380                 


Ser Val Glu Gln Glu Gln Ile Ser Asp Pro Ser Ser Asn Lys Thr Cys 
385                 390                 395                 400 


Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys Lys His 
                405                 410                 415     


Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Arg Val Cys Val 
            420                 425                 430         


Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn Cys Cys Cys Gln Asp 
        435                 440                 445             


Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Ser Gly Ser 
    450                 455                 460                 


Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
465                 470                 475                 480 


Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Cys Tyr Lys Cys Asp 
                485                 490                 495     


Lys Cys Lys Ser Glu Thr Ser Arg Ser Lys Lys Lys Trp Ile Trp Arg 
            500                 505                 510         


Ile Trp Lys Lys Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr 
        515                 520                 525             


Ala Asn Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val 
    530                 535                 540                 


Val Cys Leu Asp Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile 
545                 550                 555                 560 


Arg Thr Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His 
                565                 570                 575     


Glu Gly Lys Asn Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp Asn 
            580                 585                 590         


Gly Lys Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly 
        595                 600                 605             


Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp 
    610                 615                 620                 


Leu Glu Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr 
625                 630                 635                 640 


Ile Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu 
                645                 650                 655     


Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp 
            660                 665                 670         


Leu Ala Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Cys Gly 
        675                 680                 685             


Asp Gly Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr 
    690                 695                 700                 


Ile Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu 
705                 710                 715                 720 


His Phe Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Glu Asn 
                725                 730                 735     


Cys Lys Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Glu Cys Lys 
            740                 745                 750         


Thr Glu Cys Lys Asn Lys Cys Glu Val Tyr Lys Lys Phe Ile Glu Asp 
        755                 760                 765             


Cys Lys Gly Gly Asp Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp 
    770                 775                 780                 


Asp Gln Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg 
785                 790                 795                 800 


Asn Arg Lys Ala Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Asn 
                805                 810                 815     


Ala Ala Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys 
            820                 825                 830         


His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile 
        835                 840                 845             


Val Leu Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr 
    850                 855                 860                 


Tyr Thr Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp Lys 
865                 870                 875                 880 


Ser Lys Leu Gln Gln Cys Asn Thr Ala Val Val Val Asn Val Pro Ser 
                885                 890                 895     


Pro Leu Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys Lys 
            900                 905                 910         


Ile Pro Thr Asn His His His His His His Leu Glu His His His His 
        915                 920                 925             


His His 
    930 


<210>  4
<211>  928
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V2Cױ

<400>  4

Met Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
1               5                   10                  15      


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
            20                  25                  30          


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
        35                  40                  45              


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
    50                  55                  60                  


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
65                  70                  75                  80  


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
                85                  90                  95      


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
            100                 105                 110         


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
        115                 120                 125             


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
    130                 135                 140                 


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
145                 150                 155                 160 


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
                165                 170                 175     


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly Trp 
            180                 185                 190         


Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
        195                 200                 205             


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
    210                 215                 220                 


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
225                 230                 235                 240 


Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu Cys 
                245                 250                 255     


Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser Thr 
            260                 265                 270         


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
        275                 280                 285             


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Gln Gln 
    290                 295                 300                 


Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
305                 310                 315                 320 


Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser Ser Leu Glu 
                325                 330                 335     


Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys Leu 
            340                 345                 350         


Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Glu Lys Ile 
        355                 360                 365             


Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Gly Ile Ala 
    370                 375                 380                 


Ser Val Glu Gln Glu Gln Ile Ser Asp Pro Ser Ser Asn Lys Thr Cys 
385                 390                 395                 400 


Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys Lys His 
                405                 410                 415     


Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Arg Val Cys Val 
            420                 425                 430         


Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn Cys Cys Cys Gln Asp 
        435                 440                 445             


Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Ser Gly Ser 
    450                 455                 460                 


Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
465                 470                 475                 480 


Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Cys Tyr Lys Cys Asp 
                485                 490                 495     


Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn Trp Ile Trp 
            500                 505                 510         


Lys Lys Phe Pro Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr Ala Asn 
        515                 520                 525             


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Val Cys 
    530                 535                 540                 


Leu Asp Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg Thr 
545                 550                 555                 560 


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
                565                 570                 575     


Lys Asn Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys 
            580                 585                 590         


Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu 
        595                 600                 605             


Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu 
    610                 615                 620                 


Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys 
625                 630                 635                 640 


Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp Glu 
                645                 650                 655     


Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala 
            660                 665                 670         


Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Cys Gly Asp Gly 
        675                 680                 685             


Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile Asp 
    690                 695                 700                 


Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe 
705                 710                 715                 720 


Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Glu Asn Cys Lys 
                725                 730                 735     


Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr Glu 
            740                 745                 750         


Cys Lys Asn Lys Cys Glu Val Tyr Lys Lys Phe Ile Glu Asp Cys Lys 
        755                 760                 765             


Gly Gly Asp Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp Gln 
    770                 775                 780                 


Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg 
785                 790                 795                 800 


Lys Ala Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Asn Ala Ala 
                805                 810                 815     


Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu 
            820                 825                 830         


Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu 
        835                 840                 845             


Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr 
    850                 855                 860                 


Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp Lys Ser Lys 
865                 870                 875                 880 


Leu Gln Gln Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu 
                885                 890                 895     


Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys Lys Ile Pro 
            900                 905                 910         


Thr Asn His His His His His His Leu Glu His His His His His His 
        915                 920                 925             


<210>  5
<211>  928
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V2Cױ

<400>  5

Met Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
1               5                   10                  15      


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
            20                  25                  30          


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
        35                  40                  45              


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
    50                  55                  60                  


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
65                  70                  75                  80  


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
                85                  90                  95      


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
            100                 105                 110         


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
        115                 120                 125             


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
    130                 135                 140                 


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
145                 150                 155                 160 


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
                165                 170                 175     


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly Trp 
            180                 185                 190         


Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
        195                 200                 205             


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
    210                 215                 220                 


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
225                 230                 235                 240 


Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu Cys 
                245                 250                 255     


Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser Thr 
            260                 265                 270         


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
        275                 280                 285             


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Gln Gln 
    290                 295                 300                 


Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
305                 310                 315                 320 


Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser Ser Leu Glu 
                325                 330                 335     


Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys Leu 
            340                 345                 350         


Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Glu Lys Ile 
        355                 360                 365             


Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Gly Ile Ala 
    370                 375                 380                 


Ser Val Glu Gln Glu Gln Ile Ser Asp Pro Ser Ser Asn Lys Thr Cys 
385                 390                 395                 400 


Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys Lys His 
                405                 410                 415     


Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Arg Val Cys Val 
            420                 425                 430         


Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn Cys Cys Cys Gln Asp 
        435                 440                 445             


Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Ser Gly Ser 
    450                 455                 460                 


Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
465                 470                 475                 480 


Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Cys Tyr Lys Cys Asp 
                485                 490                 495     


Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn Trp Ile Trp 
            500                 505                 510         


Lys Lys Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr Ala Asn 
        515                 520                 525             


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Tyr Leu Gly Asn Leu 
    530                 535                 540                 


Arg Lys Leu Glu Asn Val Cys Thr Gln Glu Leu Lys Asn Ile Arg Thr 
545                 550                 555                 560 


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
                565                 570                 575     


Lys Asn Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys 
            580                 585                 590         


Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu 
        595                 600                 605             


Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu 
    610                 615                 620                 


Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys 
625                 630                 635                 640 


Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp Glu 
                645                 650                 655     


Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala 
            660                 665                 670         


Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Cys Gly Asp Gly 
        675                 680                 685             


Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile Asp 
    690                 695                 700                 


Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe 
705                 710                 715                 720 


Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Glu Asn Cys Lys 
                725                 730                 735     


Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr Glu 
            740                 745                 750         


Cys Lys Asn Lys Cys Glu Val Tyr Lys Lys Phe Ile Glu Asp Cys Lys 
        755                 760                 765             


Gly Gly Asp Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp Gln 
    770                 775                 780                 


Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg 
785                 790                 795                 800 


Lys Ala Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Asn Ala Ala 
                805                 810                 815     


Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu 
            820                 825                 830         


Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu 
        835                 840                 845             


Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr 
    850                 855                 860                 


Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp Lys Ser Lys 
865                 870                 875                 880 


Leu Gln Gln Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu 
                885                 890                 895     


Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys Lys Ile Pro 
            900                 905                 910         


Thr Asn His His His His His His Leu Glu His His His His His His 
        915                 920                 925             


<210>  6
<211>  929
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V2Cױ

<400>  6

Met Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
1               5                   10                  15      


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
            20                  25                  30          


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
        35                  40                  45              


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
    50                  55                  60                  


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
65                  70                  75                  80  


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
                85                  90                  95      


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
            100                 105                 110         


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
        115                 120                 125             


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
    130                 135                 140                 


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
145                 150                 155                 160 


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
                165                 170                 175     


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly Trp 
            180                 185                 190         


Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
        195                 200                 205             


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
    210                 215                 220                 


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
225                 230                 235                 240 


Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu Cys 
                245                 250                 255     


Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser Thr 
            260                 265                 270         


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
        275                 280                 285             


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Gln Gln 
    290                 295                 300                 


Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
305                 310                 315                 320 


Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser Ser Leu Glu 
                325                 330                 335     


Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys Leu 
            340                 345                 350         


Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Glu Lys Ile 
        355                 360                 365             


Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Gly Ile Ala 
    370                 375                 380                 


Ser Val Glu Gln Glu Gln Ile Ser Asp Pro Ser Ser Asn Lys Thr Cys 
385                 390                 395                 400 


Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys Lys His 
                405                 410                 415     


Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Arg Val Cys Val 
            420                 425                 430         


Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn Cys Cys Cys Gln Asp 
        435                 440                 445             


Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Ser Gly Ser 
    450                 455                 460                 


Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
465                 470                 475                 480 


Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Cys Tyr Lys Cys Asp 
                485                 490                 495     


Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn Trp Ile Trp 
            500                 505                 510         


Lys Lys Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr Ala Asn 
        515                 520                 525             


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Val Cys 
    530                 535                 540                 


Leu Asp Glu Lys Gly Lys Lys Thr Glu Asp Val Thr Asp Ile Asn Phe 
545                 550                 555                 560 


Asp Thr Lys Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu 
                565                 570                 575     


Gly Lys Asn Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp Asn Gly 
            580                 585                 590         


Lys Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp 
        595                 600                 605             


Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu 
    610                 615                 620                 


Glu Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile 
625                 630                 635                 640 


Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp 
                645                 650                 655     


Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Leu 
            660                 665                 670         


Ala Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Cys Gly Asp 
        675                 680                 685             


Gly Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile 
    690                 695                 700                 


Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His 
705                 710                 715                 720 


Phe Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Glu Asn Cys 
                725                 730                 735     


Lys Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr 
            740                 745                 750         


Glu Cys Lys Asn Lys Cys Glu Val Tyr Lys Lys Phe Ile Glu Asp Cys 
        755                 760                 765             


Lys Gly Gly Asp Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp 
    770                 775                 780                 


Gln Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn 
785                 790                 795                 800 


Arg Lys Ala Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Asn Ala 
                805                 810                 815     


Ala Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His 
            820                 825                 830         


Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val 
        835                 840                 845             


Leu Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr 
    850                 855                 860                 


Thr Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp Lys Ser 
865                 870                 875                 880 


Lys Leu Gln Gln Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro 
                885                 890                 895     


Leu Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys Lys Ile 
            900                 905                 910         


Pro Thr Asn His His His His His His Leu Glu His His His His His 
        915                 920                 925             


His 
    


<210>  7
<211>  929
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V2Cױ

<400>  7

Met Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
1               5                   10                  15      


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
            20                  25                  30          


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
        35                  40                  45              


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
    50                  55                  60                  


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
65                  70                  75                  80  


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
                85                  90                  95      


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
            100                 105                 110         


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
        115                 120                 125             


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
    130                 135                 140                 


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
145                 150                 155                 160 


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
                165                 170                 175     


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly Trp 
            180                 185                 190         


Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
        195                 200                 205             


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
    210                 215                 220                 


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
225                 230                 235                 240 


Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu Cys 
                245                 250                 255     


Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser Thr 
            260                 265                 270         


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
        275                 280                 285             


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Gln Gln 
    290                 295                 300                 


Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
305                 310                 315                 320 


Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser Ser Leu Glu 
                325                 330                 335     


Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys Leu 
            340                 345                 350         


Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Glu Lys Ile 
        355                 360                 365             


Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Gly Ile Ala 
    370                 375                 380                 


Ser Val Glu Gln Glu Gln Ile Ser Asp Pro Ser Ser Asn Lys Thr Cys 
385                 390                 395                 400 


Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys Lys His 
                405                 410                 415     


Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Arg Val Cys Val 
            420                 425                 430         


Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn Cys Cys Cys Gln Asp 
        435                 440                 445             


Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Ser Gly Ser 
    450                 455                 460                 


Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
465                 470                 475                 480 


Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Cys Tyr Lys Cys Asp 
                485                 490                 495     


Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn Trp Ile Trp 
            500                 505                 510         


Lys Lys Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr Ala Asn 
        515                 520                 525             


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Val Cys 
    530                 535                 540                 


Leu Asp Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg Thr 
545                 550                 555                 560 


Asn Ser Glu Lys Phe Leu Ala Gly Cys Leu Ile Ala Ala Phe His Glu 
                565                 570                 575     


Gly Lys Asn Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp Asn Gly 
            580                 585                 590         


Lys Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp 
        595                 600                 605             


Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu 
    610                 615                 620                 


Glu Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile 
625                 630                 635                 640 


Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp 
                645                 650                 655     


Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Leu 
            660                 665                 670         


Ala Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Cys Gly Asp 
        675                 680                 685             


Gly Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile 
    690                 695                 700                 


Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His 
705                 710                 715                 720 


Phe Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Glu Asn Cys 
                725                 730                 735     


Lys Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr 
            740                 745                 750         


Glu Cys Lys Asn Lys Cys Glu Val Tyr Lys Lys Phe Ile Glu Asp Cys 
        755                 760                 765             


Lys Gly Gly Asp Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp 
    770                 775                 780                 


Gln Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn 
785                 790                 795                 800 


Arg Lys Ala Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Asn Ala 
                805                 810                 815     


Ala Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His 
            820                 825                 830         


Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val 
        835                 840                 845             


Leu Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr 
    850                 855                 860                 


Thr Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp Lys Ser 
865                 870                 875                 880 


Lys Leu Gln Gln Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro 
                885                 890                 895     


Leu Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys Lys Ile 
            900                 905                 910         


Pro Thr Asn His His His His His His Leu Glu His His His His His 
        915                 920                 925             


His 
    


<210>  8
<211>  928
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V2Cױ

<400>  8

Met Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
1               5                   10                  15      


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
            20                  25                  30          


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
        35                  40                  45              


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
    50                  55                  60                  


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
65                  70                  75                  80  


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
                85                  90                  95      


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
            100                 105                 110         


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
        115                 120                 125             


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
    130                 135                 140                 


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
145                 150                 155                 160 


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
                165                 170                 175     


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly Trp 
            180                 185                 190         


Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
        195                 200                 205             


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
    210                 215                 220                 


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
225                 230                 235                 240 


Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu Cys 
                245                 250                 255     


Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser Thr 
            260                 265                 270         


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
        275                 280                 285             


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Gln Gln 
    290                 295                 300                 


Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
305                 310                 315                 320 


Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser Ser Leu Glu 
                325                 330                 335     


Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys Leu 
            340                 345                 350         


Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Glu Lys Ile 
        355                 360                 365             


Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Gly Ile Ala 
    370                 375                 380                 


Ser Val Glu Gln Glu Gln Ile Ser Asp Pro Ser Ser Asn Lys Thr Cys 
385                 390                 395                 400 


Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys Lys His 
                405                 410                 415     


Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Arg Val Cys Val 
            420                 425                 430         


Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn Cys Cys Cys Gln Asp 
        435                 440                 445             


Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Ser Gly Ser 
    450                 455                 460                 


Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
465                 470                 475                 480 


Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Cys Tyr Lys Cys Asp 
                485                 490                 495     


Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn Trp Ile Trp 
            500                 505                 510         


Lys Lys Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr Ala Asn 
        515                 520                 525             


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Val Cys 
    530                 535                 540                 


Leu Asp Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg Thr 
545                 550                 555                 560 


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
                565                 570                 575     


Lys Asn Leu Lys Thr Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys 
            580                 585                 590         


Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu 
        595                 600                 605             


Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu 
    610                 615                 620                 


Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys 
625                 630                 635                 640 


Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp Glu 
                645                 650                 655     


Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala 
            660                 665                 670         


Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Cys Gly Asp Gly 
        675                 680                 685             


Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile Asp 
    690                 695                 700                 


Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe 
705                 710                 715                 720 


Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Glu Asn Cys Lys 
                725                 730                 735     


Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr Glu 
            740                 745                 750         


Cys Lys Asn Lys Cys Glu Val Tyr Lys Lys Phe Ile Glu Asp Cys Lys 
        755                 760                 765             


Gly Gly Asp Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp Gln 
    770                 775                 780                 


Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg 
785                 790                 795                 800 


Lys Ala Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Asn Ala Ala 
                805                 810                 815     


Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu 
            820                 825                 830         


Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu 
        835                 840                 845             


Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr 
    850                 855                 860                 


Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp Lys Ser Lys 
865                 870                 875                 880 


Leu Gln Gln Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu 
                885                 890                 895     


Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys Lys Ile Pro 
            900                 905                 910         


Thr Asn His His His His His His Leu Glu His His His His His His 
        915                 920                 925             


<210>  9
<211>  935
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V2Cױ

<400>  9

Met Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
1               5                   10                  15      


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
            20                  25                  30          


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
        35                  40                  45              


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
    50                  55                  60                  


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
65                  70                  75                  80  


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
                85                  90                  95      


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
            100                 105                 110         


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
        115                 120                 125             


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
    130                 135                 140                 


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
145                 150                 155                 160 


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
                165                 170                 175     


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly Trp 
            180                 185                 190         


Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
        195                 200                 205             


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
    210                 215                 220                 


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
225                 230                 235                 240 


Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu Cys 
                245                 250                 255     


Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser Thr 
            260                 265                 270         


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
        275                 280                 285             


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Gln Gln 
    290                 295                 300                 


Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
305                 310                 315                 320 


Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser Ser Leu Glu 
                325                 330                 335     


Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys Leu 
            340                 345                 350         


Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Glu Lys Ile 
        355                 360                 365             


Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Gly Ile Ala 
    370                 375                 380                 


Ser Val Glu Gln Glu Gln Ile Ser Asp Pro Ser Ser Asn Lys Thr Cys 
385                 390                 395                 400 


Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys Lys His 
                405                 410                 415     


Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Arg Val Cys Val 
            420                 425                 430         


Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn Cys Cys Cys Gln Asp 
        435                 440                 445             


Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Ser Gly Ser 
    450                 455                 460                 


Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
465                 470                 475                 480 


Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Cys Tyr Lys Cys Asp 
                485                 490                 495     


Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn Trp Ile Trp 
            500                 505                 510         


Lys Lys Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr Ala Asn 
        515                 520                 525             


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Val Cys 
    530                 535                 540                 


Leu Asp Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg Thr 
545                 550                 555                 560 


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
                565                 570                 575     


Lys Asn Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys 
            580                 585                 590         


Lys Asn Asp Asp Asn Asn Ser Lys Leu Cys Lys Ala Leu Glu Tyr Ser 
        595                 600                 605             


Phe Ala Asp Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn 
    610                 615                 620                 


Glu Tyr Thr Lys Asp Leu Glu Leu Asn Leu Gln Lys Ile Phe Gly Lys 
625                 630                 635                 640 


Leu Phe Arg Lys Tyr Ile Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr 
                645                 650                 655     


Ser Tyr Ser Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn 
            660                 665                 670         


Lys Lys Tyr Ile Trp Leu Ala Met Lys His Gly Ala Gly Met Asn Ser 
        675                 680                 685             


Thr Thr Cys Cys Gly Asp Gly Ser Val Thr Gly Ser Gly Ser Ser Cys 
    690                 695                 700                 


Asp Asp Ile Pro Thr Ile Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu 
705                 710                 715                 720 


Gln Glu Trp Val Glu His Phe Cys Lys Gln Arg Gln Glu Lys Val Lys 
                725                 730                 735     


Pro Val Ile Glu Asn Cys Lys Ser Cys Lys Glu Ser Gly Gly Thr Cys 
            740                 745                 750         


Asn Gly Glu Cys Lys Thr Glu Cys Lys Asn Lys Cys Glu Val Tyr Lys 
        755                 760                 765             


Lys Phe Ile Glu Asp Cys Lys Gly Gly Asp Gly Thr Ala Gly Ser Ser 
    770                 775                 780                 


Trp Val Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile 
785                 790                 795                 800 


Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn Cys Gly Pro 
                805                 810                 815     


Ser Ser Thr Thr Asn Ala Ala Glu Asn Lys Cys Val Gln Ser Asp Ile 
            820                 825                 830         


Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser 
        835                 840                 845             


Ser Tyr Leu Ser Ile Val Leu Asp Asp Asn Ile Cys Gly Ala Asp Lys 
    850                 855                 860                 


Ala Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr Thr Glu Lys Cys Asn 
865                 870                 875                 880 


Lys Glu Thr Asp Lys Ser Lys Leu Gln Gln Cys Asn Thr Ala Val Val 
                885                 890                 895     


Val Asn Val Pro Ser Pro Leu Gly Asn Thr Pro His Gly Tyr Lys Tyr 
            900                 905                 910         


Ala Cys Gln Cys Lys Ile Pro Thr Asn His His His His His His Leu 
        915                 920                 925             


Glu His His His His His His 
    930                 935 


<210>  10
<211>  928
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V2Cױ

<400>  10

Met Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
1               5                   10                  15      


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
            20                  25                  30          


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
        35                  40                  45              


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
    50                  55                  60                  


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
65                  70                  75                  80  


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
                85                  90                  95      


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
            100                 105                 110         


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
        115                 120                 125             


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
    130                 135                 140                 


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
145                 150                 155                 160 


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
                165                 170                 175     


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly Trp 
            180                 185                 190         


Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
        195                 200                 205             


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
    210                 215                 220                 


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
225                 230                 235                 240 


Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu Cys 
                245                 250                 255     


Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser Thr 
            260                 265                 270         


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
        275                 280                 285             


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Gln Gln 
    290                 295                 300                 


Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
305                 310                 315                 320 


Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser Ser Leu Glu 
                325                 330                 335     


Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys Leu 
            340                 345                 350         


Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Glu Lys Ile 
        355                 360                 365             


Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Gly Ile Ala 
    370                 375                 380                 


Ser Val Glu Gln Glu Gln Ile Ser Asp Pro Ser Ser Asn Lys Thr Cys 
385                 390                 395                 400 


Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys Lys His 
                405                 410                 415     


Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Arg Val Cys Val 
            420                 425                 430         


Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn Cys Cys Cys Gln Asp 
        435                 440                 445             


Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Ser Gly Ser 
    450                 455                 460                 


Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
465                 470                 475                 480 


Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Cys Tyr Lys Cys Asp 
                485                 490                 495     


Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn Trp Ile Trp 
            500                 505                 510         


Lys Lys Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr Ala Asn 
        515                 520                 525             


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Val Cys 
    530                 535                 540                 


Leu Asp Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg Thr 
545                 550                 555                 560 


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
                565                 570                 575     


Lys Asn Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys 
            580                 585                 590         


Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu 
        595                 600                 605             


Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu 
    610                 615                 620                 


Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys 
625                 630                 635                 640 


Lys Asn Ile Ala Ser Asp Glu Asn Thr Leu Tyr Ser Ser Leu Asp Glu 
                645                 650                 655     


Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala 
            660                 665                 670         


Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Cys Gly Asp Gly 
        675                 680                 685             


Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile Asp 
    690                 695                 700                 


Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe 
705                 710                 715                 720 


Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Glu Asn Cys Lys 
                725                 730                 735     


Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr Glu 
            740                 745                 750         


Cys Lys Asn Lys Cys Glu Val Tyr Lys Lys Phe Ile Glu Asp Cys Lys 
        755                 760                 765             


Gly Gly Asp Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp Gln 
    770                 775                 780                 


Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg 
785                 790                 795                 800 


Lys Ala Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Asn Ala Ala 
                805                 810                 815     


Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu 
            820                 825                 830         


Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu 
        835                 840                 845             


Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr 
    850                 855                 860                 


Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp Lys Ser Lys 
865                 870                 875                 880 


Leu Gln Gln Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu 
                885                 890                 895     


Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys Lys Ile Pro 
            900                 905                 910         


Thr Asn His His His His His His Leu Glu His His His His His His 
        915                 920                 925             


<210>  11
<211>  929
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V2Cױ

<400>  11

Met Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
1               5                   10                  15      


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
            20                  25                  30          


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
        35                  40                  45              


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
    50                  55                  60                  


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
65                  70                  75                  80  


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
                85                  90                  95      


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
            100                 105                 110         


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
        115                 120                 125             


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
    130                 135                 140                 


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
145                 150                 155                 160 


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
                165                 170                 175     


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly Trp 
            180                 185                 190         


Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
        195                 200                 205             


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
    210                 215                 220                 


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
225                 230                 235                 240 


Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu Cys 
                245                 250                 255     


Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser Thr 
            260                 265                 270         


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
        275                 280                 285             


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Gln Gln 
    290                 295                 300                 


Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
305                 310                 315                 320 


Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser Ser Leu Glu 
                325                 330                 335     


Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys Leu 
            340                 345                 350         


Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Glu Lys Ile 
        355                 360                 365             


Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Gly Ile Ala 
    370                 375                 380                 


Ser Val Glu Gln Glu Gln Ile Ser Asp Pro Ser Ser Asn Lys Thr Cys 
385                 390                 395                 400 


Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys Lys His 
                405                 410                 415     


Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Arg Val Cys Val 
            420                 425                 430         


Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn Cys Cys Cys Gln Asp 
        435                 440                 445             


Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Ser Gly Ser 
    450                 455                 460                 


Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
465                 470                 475                 480 


Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Cys Tyr Lys Cys Asp 
                485                 490                 495     


Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn Trp Ile Trp 
            500                 505                 510         


Lys Lys Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr Ala Asn 
        515                 520                 525             


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Val Cys 
    530                 535                 540                 


Leu Asp Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg Thr 
545                 550                 555                 560 


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
                565                 570                 575     


Lys Asn Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys 
            580                 585                 590         


Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu 
        595                 600                 605             


Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu 
    610                 615                 620                 


Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys 
625                 630                 635                 640 


Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp Glu 
                645                 650                 655     


Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Ile Ala 
            660                 665                 670         


Met Lys His Gly Ala Gly Met Asn Gly Thr Thr Cys Cys Gly Asp Gly 
        675                 680                 685             


Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile Asp 
    690                 695                 700                 


Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe 
705                 710                 715                 720 


Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Glu Asn Cys Lys 
                725                 730                 735     


Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr Glu 
            740                 745                 750         


Cys Lys Asn Lys Cys Glu Val Tyr Lys Lys Phe Ile Glu Asp Cys Lys 
        755                 760                 765             


Gly Gly Asp Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp Gln 
    770                 775                 780                 


Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg 
785                 790                 795                 800 


Lys Ala Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Asn Ala Ala 
                805                 810                 815     


Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu 
            820                 825                 830         


Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu 
        835                 840                 845             


Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr 
    850                 855                 860                 


Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp Lys Ser Lys 
865                 870                 875                 880 


Leu Gln Gln Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu 
                885                 890                 895     


Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys Lys Ile Pro 
            900                 905                 910         


Thr Asn Lys His His His His His His Leu Glu His His His His His 
        915                 920                 925             


His 
    


<210>  12
<211>  935
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V2Cױ

<400>  12

Met Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
1               5                   10                  15      


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
            20                  25                  30          


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
        35                  40                  45              


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
    50                  55                  60                  


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
65                  70                  75                  80  


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
                85                  90                  95      


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
            100                 105                 110         


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
        115                 120                 125             


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
    130                 135                 140                 


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
145                 150                 155                 160 


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
                165                 170                 175     


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly Trp 
            180                 185                 190         


Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
        195                 200                 205             


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
    210                 215                 220                 


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
225                 230                 235                 240 


Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu Cys 
                245                 250                 255     


Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser Thr 
            260                 265                 270         


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
        275                 280                 285             


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Gln Gln 
    290                 295                 300                 


Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
305                 310                 315                 320 


Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser Ser Leu Glu 
                325                 330                 335     


Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys Leu 
            340                 345                 350         


Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Glu Lys Ile 
        355                 360                 365             


Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Gly Ile Ala 
    370                 375                 380                 


Ser Val Glu Gln Glu Gln Ile Ser Asp Pro Ser Ser Asn Lys Thr Cys 
385                 390                 395                 400 


Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys Lys His 
                405                 410                 415     


Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Arg Val Cys Val 
            420                 425                 430         


Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn Cys Cys Cys Gln Asp 
        435                 440                 445             


Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Ser Gly Ser 
    450                 455                 460                 


Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
465                 470                 475                 480 


Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Cys Tyr Lys Cys Asp 
                485                 490                 495     


Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn Trp Ile Trp 
            500                 505                 510         


Lys Lys Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr Ala Asn 
        515                 520                 525             


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Val Cys 
    530                 535                 540                 


Leu Asp Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg Thr 
545                 550                 555                 560 


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
                565                 570                 575     


Lys Asn Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys 
            580                 585                 590         


Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu 
        595                 600                 605             


Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu 
    610                 615                 620                 


Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys 
625                 630                 635                 640 


Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp Glu 
                645                 650                 655     


Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala 
            660                 665                 670         


Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Ser Ser Gly Ser 
        675                 680                 685             


Gly Asp Asn Gly Asp Gly Ser Val Thr Gly Ser Gly Ser Ser Cys Asp 
    690                 695                 700                 


Asp Ile Pro Thr Ile Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln 
705                 710                 715                 720 


Glu Trp Val Glu His Phe Cys Lys Gln Arg Gln Glu Lys Val Lys Pro 
                725                 730                 735     


Val Ile Glu Asn Cys Lys Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn 
            740                 745                 750         


Gly Glu Cys Lys Thr Glu Cys Lys Asn Lys Cys Glu Val Tyr Lys Lys 
        755                 760                 765             


Phe Ile Glu Asp Cys Lys Gly Gly Asp Gly Thr Ala Gly Ser Ser Trp 
    770                 775                 780                 


Val Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu 
785                 790                 795                 800 


Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn Cys Gly Pro Ser 
                805                 810                 815     


Ser Thr Thr Asn Ala Ala Glu Asn Lys Cys Val Gln Ser Asp Ile Asp 
            820                 825                 830         


Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser 
        835                 840                 845             


Tyr Leu Ser Ile Val Leu Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala 
    850                 855                 860                 


Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys 
865                 870                 875                 880 


Glu Thr Asp Lys Ser Lys Leu Gln Gln Cys Asn Thr Ala Val Val Val 
                885                 890                 895     


Asn Val Pro Ser Pro Leu Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala 
            900                 905                 910         


Cys Gln Cys Lys Ile Pro Thr Asn Lys His His His His His His Leu 
        915                 920                 925             


Glu His His His His His His 
    930                 935 


<210>  13
<211>  931
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V2Cױ

<400>  13

Met Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
1               5                   10                  15      


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
            20                  25                  30          


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
        35                  40                  45              


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
    50                  55                  60                  


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
65                  70                  75                  80  


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
                85                  90                  95      


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
            100                 105                 110         


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
        115                 120                 125             


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
    130                 135                 140                 


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
145                 150                 155                 160 


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
                165                 170                 175     


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly Trp 
            180                 185                 190         


Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
        195                 200                 205             


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
    210                 215                 220                 


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
225                 230                 235                 240 


Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu Cys 
                245                 250                 255     


Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser Thr 
            260                 265                 270         


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
        275                 280                 285             


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Gln Gln 
    290                 295                 300                 


Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
305                 310                 315                 320 


Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser Ser Leu Glu 
                325                 330                 335     


Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys Leu 
            340                 345                 350         


Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Glu Lys Ile 
        355                 360                 365             


Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Gly Ile Ala 
    370                 375                 380                 


Ser Val Glu Gln Glu Gln Ile Ser Asp Pro Ser Ser Asn Lys Thr Cys 
385                 390                 395                 400 


Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys Lys His 
                405                 410                 415     


Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Arg Val Cys Val 
            420                 425                 430         


Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn Cys Cys Cys Gln Asp 
        435                 440                 445             


Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Ser Gly Ser 
    450                 455                 460                 


Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
465                 470                 475                 480 


Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Cys Tyr Lys Cys Asp 
                485                 490                 495     


Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn Trp Ile Trp 
            500                 505                 510         


Lys Lys Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr Ala Asn 
        515                 520                 525             


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Val Cys 
    530                 535                 540                 


Leu Asp Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg Thr 
545                 550                 555                 560 


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
                565                 570                 575     


Lys Asn Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys 
            580                 585                 590         


Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu 
        595                 600                 605             


Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu 
    610                 615                 620                 


Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys 
625                 630                 635                 640 


Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp Glu 
                645                 650                 655     


Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala 
            660                 665                 670         


Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Cys Gly Asp Gly 
        675                 680                 685             


Ser Val Thr Gly Ser Ser Asp Ser Gly Ser Thr Cys Asp Asp Ile Pro 
    690                 695                 700                 


Thr Ile Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val 
705                 710                 715                 720 


Glu His Phe Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Glu 
                725                 730                 735     


Asn Cys Lys Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Glu Cys 
            740                 745                 750         


Lys Thr Glu Cys Lys Asn Lys Cys Glu Val Tyr Lys Lys Phe Ile Glu 
        755                 760                 765             


Asp Cys Lys Gly Gly Asp Gly Thr Ala Gly Ser Ser Trp Val Lys Arg 
    770                 775                 780                 


Trp Asp Gln Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys 
785                 790                 795                 800 


Arg Asn Arg Lys Ala Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr 
                805                 810                 815     


Asn Ala Ala Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe 
            820                 825                 830         


Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser 
        835                 840                 845             


Ile Val Leu Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr 
    850                 855                 860                 


Thr Tyr Thr Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp 
865                 870                 875                 880 


Lys Ser Lys Leu Gln Gln Cys Asn Thr Ala Val Val Val Asn Val Pro 
                885                 890                 895     


Ser Pro Leu Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys 
            900                 905                 910         


Lys Ile Pro Thr Asn His His His His His His Leu Glu His His His 
        915                 920                 925             


His His His 
    930     


<210>  14
<211>  938
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V2Cױ

<400>  14

Met Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
1               5                   10                  15      


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
            20                  25                  30          


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
        35                  40                  45              


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
    50                  55                  60                  


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
65                  70                  75                  80  


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
                85                  90                  95      


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
            100                 105                 110         


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
        115                 120                 125             


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
    130                 135                 140                 


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
145                 150                 155                 160 


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
                165                 170                 175     


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly Trp 
            180                 185                 190         


Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
        195                 200                 205             


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
    210                 215                 220                 


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
225                 230                 235                 240 


Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu Cys 
                245                 250                 255     


Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser Thr 
            260                 265                 270         


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
        275                 280                 285             


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Gln Gln 
    290                 295                 300                 


Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
305                 310                 315                 320 


Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser Ser Leu Glu 
                325                 330                 335     


Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys Leu 
            340                 345                 350         


Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Glu Lys Ile 
        355                 360                 365             


Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Gly Ile Ala 
    370                 375                 380                 


Ser Val Glu Gln Glu Gln Ile Ser Asp Pro Ser Ser Asn Lys Thr Cys 
385                 390                 395                 400 


Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys Lys His 
                405                 410                 415     


Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Arg Val Cys Val 
            420                 425                 430         


Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn Cys Cys Cys Gln Asp 
        435                 440                 445             


Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Ser Gly Ser 
    450                 455                 460                 


Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
465                 470                 475                 480 


Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Cys Tyr Lys Cys Asp 
                485                 490                 495     


Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn Trp Ile Trp 
            500                 505                 510         


Lys Lys Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr Ala Asn 
        515                 520                 525             


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Val Cys 
    530                 535                 540                 


Leu Asp Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg Thr 
545                 550                 555                 560 


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
                565                 570                 575     


Lys Asn Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys 
            580                 585                 590         


Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu 
        595                 600                 605             


Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu 
    610                 615                 620                 


Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys 
625                 630                 635                 640 


Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp Glu 
                645                 650                 655     


Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala 
            660                 665                 670         


Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Cys Gly Asp Gly 
        675                 680                 685             


Ser Val Thr Gly Ser Gly Ser Ser Thr Cys Ser Gly Asp Asn Gly Ser 
    690                 695                 700                 


Ile Ser Cys Asp Asp Ile Pro Thr Ile Asp Leu Ile Pro Gln Tyr Leu 
705                 710                 715                 720 


Arg Phe Leu Gln Glu Trp Val Glu His Phe Cys Lys Gln Arg Gln Glu 
                725                 730                 735     


Lys Val Lys Pro Val Ile Glu Asn Cys Lys Ser Cys Lys Glu Ser Gly 
            740                 745                 750         


Gly Thr Cys Asn Gly Glu Cys Lys Thr Glu Cys Lys Asn Lys Cys Glu 
        755                 760                 765             


Val Tyr Lys Lys Phe Ile Glu Asp Cys Lys Gly Gly Asp Gly Thr Ala 
    770                 775                 780                 


Gly Ser Ser Trp Val Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr Ser 
785                 790                 795                 800 


Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn 
                805                 810                 815     


Cys Gly Pro Ser Ser Thr Thr Asn Ala Ala Glu Asn Lys Cys Val Gln 
            820                 825                 830         


Ser Asp Ile Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr 
        835                 840                 845             


Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu Asp Asp Asn Ile Cys Gly 
    850                 855                 860                 


Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr Thr Glu 
865                 870                 875                 880 


Lys Cys Asn Lys Glu Thr Asp Lys Ser Lys Leu Gln Gln Cys Asn Thr 
                885                 890                 895     


Ala Val Val Val Asn Val Pro Ser Pro Leu Gly Asn Thr Pro His Gly 
            900                 905                 910         


Tyr Lys Tyr Ala Cys Gln Cys Lys Ile Pro Thr Asn His His His His 
        915                 920                 925             


His His Leu Glu His His His His His His 
    930                 935             


<210>  15
<211>  934
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V2Cױ

<400>  15

Met Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
1               5                   10                  15      


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
            20                  25                  30          


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
        35                  40                  45              


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
    50                  55                  60                  


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
65                  70                  75                  80  


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
                85                  90                  95      


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
            100                 105                 110         


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
        115                 120                 125             


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
    130                 135                 140                 


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
145                 150                 155                 160 


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
                165                 170                 175     


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly Trp 
            180                 185                 190         


Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
        195                 200                 205             


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
    210                 215                 220                 


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
225                 230                 235                 240 


Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu Cys 
                245                 250                 255     


Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser Thr 
            260                 265                 270         


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
        275                 280                 285             


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Gln Gln 
    290                 295                 300                 


Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
305                 310                 315                 320 


Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser Ser Leu Glu 
                325                 330                 335     


Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys Leu 
            340                 345                 350         


Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Glu Lys Ile 
        355                 360                 365             


Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Gly Ile Ala 
    370                 375                 380                 


Ser Val Glu Gln Glu Gln Ile Ser Asp Pro Ser Ser Asn Lys Thr Cys 
385                 390                 395                 400 


Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys Lys His 
                405                 410                 415     


Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Arg Val Cys Val 
            420                 425                 430         


Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn Cys Cys Cys Gln Asp 
        435                 440                 445             


Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Ser Gly Ser 
    450                 455                 460                 


Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
465                 470                 475                 480 


Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Cys Tyr Lys Cys Asp 
                485                 490                 495     


Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn Trp Ile Trp 
            500                 505                 510         


Lys Lys Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr Ala Asn 
        515                 520                 525             


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Val Cys 
    530                 535                 540                 


Leu Asp Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg Thr 
545                 550                 555                 560 


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
                565                 570                 575     


Lys Asn Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys 
            580                 585                 590         


Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu 
        595                 600                 605             


Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu 
    610                 615                 620                 


Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys 
625                 630                 635                 640 


Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp Glu 
                645                 650                 655     


Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala 
            660                 665                 670         


Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Cys Gly Asp Gly 
        675                 680                 685             


Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile Asp 
    690                 695                 700                 


Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe 
705                 710                 715                 720 


Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Glu Asn Cys Lys 
                725                 730                 735     


Ser Cys Lys Asn Thr Ser Gly Glu Arg Lys Ile Gly Gly Thr Cys Asn 
            740                 745                 750         


Gly Glu Cys Lys Thr Glu Cys Lys Asn Lys Cys Glu Val Tyr Lys Lys 
        755                 760                 765             


Phe Ile Glu Asp Cys Lys Gly Gly Asp Gly Thr Ala Gly Ser Ser Trp 
    770                 775                 780                 


Val Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu 
785                 790                 795                 800 


Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn Cys Gly Pro Ser 
                805                 810                 815     


Ser Thr Thr Asn Ala Ala Glu Asn Lys Cys Val Gln Ser Asp Ile Asp 
            820                 825                 830         


Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser 
        835                 840                 845             


Tyr Leu Ser Ile Val Leu Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala 
    850                 855                 860                 


Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys 
865                 870                 875                 880 


Glu Thr Asp Lys Ser Lys Leu Gln Gln Cys Asn Thr Ala Val Val Val 
                885                 890                 895     


Asn Val Pro Ser Pro Leu Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala 
            900                 905                 910         


Cys Gln Cys Lys Ile Pro Thr Asn His His His His His His Leu Glu 
        915                 920                 925             


His His His His His His 
    930                 


<210>  16
<211>  927
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V2Cױ

<400>  16

Met Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
1               5                   10                  15      


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
            20                  25                  30          


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
        35                  40                  45              


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
    50                  55                  60                  


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
65                  70                  75                  80  


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
                85                  90                  95      


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
            100                 105                 110         


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
        115                 120                 125             


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
    130                 135                 140                 


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
145                 150                 155                 160 


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
                165                 170                 175     


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly Trp 
            180                 185                 190         


Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
        195                 200                 205             


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
    210                 215                 220                 


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
225                 230                 235                 240 


Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu Cys 
                245                 250                 255     


Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser Thr 
            260                 265                 270         


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
        275                 280                 285             


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Gln Gln 
    290                 295                 300                 


Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
305                 310                 315                 320 


Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser Ser Leu Glu 
                325                 330                 335     


Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys Leu 
            340                 345                 350         


Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Glu Lys Ile 
        355                 360                 365             


Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Gly Ile Ala 
    370                 375                 380                 


Ser Val Glu Gln Glu Gln Ile Ser Asp Pro Ser Ser Asn Lys Thr Cys 
385                 390                 395                 400 


Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys Lys His 
                405                 410                 415     


Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Arg Val Cys Val 
            420                 425                 430         


Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn Cys Cys Cys Gln Asp 
        435                 440                 445             


Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Ser Gly Ser 
    450                 455                 460                 


Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
465                 470                 475                 480 


Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Cys Tyr Lys Cys Asp 
                485                 490                 495     


Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn Trp Ile Trp 
            500                 505                 510         


Lys Lys Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr Ala Asn 
        515                 520                 525             


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Val Cys 
    530                 535                 540                 


Leu Asp Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg Thr 
545                 550                 555                 560 


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
                565                 570                 575     


Lys Asn Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys 
            580                 585                 590         


Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu 
        595                 600                 605             


Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu 
    610                 615                 620                 


Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys 
625                 630                 635                 640 


Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp Glu 
                645                 650                 655     


Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala 
            660                 665                 670         


Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Cys Gly Asp Gly 
        675                 680                 685             


Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile Asp 
    690                 695                 700                 


Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe 
705                 710                 715                 720 


Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Glu Asn Cys Lys 
                725                 730                 735     


Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Glu Cys Glu Lys Lys 
            740                 745                 750         


Cys Asn Lys Cys Glu Ala Tyr Lys Lys Phe Ile Glu Asp Cys Lys Gly 
        755                 760                 765             


Gly Asp Gly Thr Ala Gly Ser Ser Trp Val Lys Arg Trp Asp Gln Ile 
    770                 775                 780                 


Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn Arg Lys 
785                 790                 795                 800 


Ala Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Asn Ala Ala Glu 
                805                 810                 815     


Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His Leu Ile 
            820                 825                 830         


Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val Leu Asp 
        835                 840                 845             


Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr 
    850                 855                 860                 


Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp Lys Ser Lys Leu 
865                 870                 875                 880 


Gln Gln Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro Leu Gly 
                885                 890                 895     


Asn Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys Lys Ile Pro Thr 
            900                 905                 910         


Asn His His His His His His Leu Glu His His His His His His 
        915                 920                 925         


<210>  17
<211>  929
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V2Cױ

<400>  17

Met Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
1               5                   10                  15      


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
            20                  25                  30          


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
        35                  40                  45              


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
    50                  55                  60                  


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
65                  70                  75                  80  


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
                85                  90                  95      


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
            100                 105                 110         


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
        115                 120                 125             


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
    130                 135                 140                 


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
145                 150                 155                 160 


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
                165                 170                 175     


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly Trp 
            180                 185                 190         


Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
        195                 200                 205             


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
    210                 215                 220                 


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
225                 230                 235                 240 


Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu Cys 
                245                 250                 255     


Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser Thr 
            260                 265                 270         


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
        275                 280                 285             


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Gln Gln 
    290                 295                 300                 


Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
305                 310                 315                 320 


Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser Ser Leu Glu 
                325                 330                 335     


Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys Leu 
            340                 345                 350         


Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Glu Lys Ile 
        355                 360                 365             


Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Gly Ile Ala 
    370                 375                 380                 


Ser Val Glu Gln Glu Gln Ile Ser Asp Pro Ser Ser Asn Lys Thr Cys 
385                 390                 395                 400 


Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys Lys His 
                405                 410                 415     


Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Arg Val Cys Val 
            420                 425                 430         


Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn Cys Cys Cys Gln Asp 
        435                 440                 445             


Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Ser Gly Ser 
    450                 455                 460                 


Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
465                 470                 475                 480 


Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Cys Tyr Lys Cys Asp 
                485                 490                 495     


Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn Trp Ile Trp 
            500                 505                 510         


Lys Lys Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr Ala Asn 
        515                 520                 525             


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Val Cys 
    530                 535                 540                 


Leu Asp Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg Thr 
545                 550                 555                 560 


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
                565                 570                 575     


Lys Asn Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys 
            580                 585                 590         


Lys Leu Cys Lys Ala Leu Glu Tyr Ser Phe Ala Asp Tyr Gly Asp Leu 
        595                 600                 605             


Ile Lys Gly Thr Ser Ile Trp Asp Asn Glu Tyr Thr Lys Asp Leu Glu 
    610                 615                 620                 


Leu Asn Leu Gln Lys Ile Phe Gly Lys Leu Phe Arg Lys Tyr Ile Lys 
625                 630                 635                 640 


Lys Asn Asn Thr Ala Glu Gln Asp Thr Ser Tyr Ser Ser Leu Asp Glu 
                645                 650                 655     


Leu Arg Glu Ser Trp Trp Asn Thr Asn Lys Lys Tyr Ile Trp Leu Ala 
            660                 665                 670         


Met Lys His Gly Ala Gly Met Asn Ser Thr Thr Cys Cys Gly Asp Gly 
        675                 680                 685             


Ser Val Thr Gly Ser Gly Ser Ser Cys Asp Asp Ile Pro Thr Ile Asp 
    690                 695                 700                 


Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val Glu His Phe 
705                 710                 715                 720 


Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Glu Asn Cys Lys 
                725                 730                 735     


Ser Cys Lys Glu Ser Gly Gly Thr Cys Asn Gly Glu Cys Lys Thr Glu 
            740                 745                 750         


Cys Lys Asn Lys Cys Glu Val Tyr Lys Lys Phe Ile Glu Glu Cys Val 
        755                 760                 765             


Thr Ala Val Gly Gly Thr Ser Gly Ser Pro Trp Ser Lys Arg Trp Asp 
    770                 775                 780                 


Gln Ile Tyr Lys Arg Tyr Ser Lys Tyr Ile Glu Asp Ala Lys Arg Asn 
785                 790                 795                 800 


Arg Lys Ala Gly Thr Lys Asn Cys Gly Pro Ser Ser Thr Thr Asn Ala 
                805                 810                 815     


Ala Glu Asn Lys Cys Val Gln Ser Asp Ile Asp Ser Phe Phe Lys His 
            820                 825                 830         


Leu Ile Asp Ile Gly Leu Thr Thr Pro Ser Ser Tyr Leu Ser Ile Val 
        835                 840                 845             


Leu Asp Asp Asn Ile Cys Gly Ala Asp Lys Ala Pro Trp Thr Thr Tyr 
    850                 855                 860                 


Thr Thr Tyr Thr Thr Thr Glu Lys Cys Asn Lys Glu Thr Asp Lys Ser 
865                 870                 875                 880 


Lys Leu Gln Gln Cys Asn Thr Ala Val Val Val Asn Val Pro Ser Pro 
                885                 890                 895     


Leu Gly Asn Thr Pro His Gly Tyr Lys Tyr Ala Cys Gln Cys Lys Ile 
            900                 905                 910         


Pro Thr Asn His His His His His His Leu Glu His His His His His 
        915                 920                 925             


His 
    


<210>  18
<211>  953
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V2Cױ

<400>  18

Met Ile Cys Lys Ile Thr Val Asn His Ser Asp Ser Gly Thr Asn Asp 
1               5                   10                  15      


Pro Cys Asp Arg Ile Pro Pro Pro Tyr Gly Asp Asn Asp Gln Trp Lys 
            20                  25                  30          


Cys Ala Ile Ile Leu Ser Lys Val Ser Glu Lys Pro Glu Asn Val Phe 
        35                  40                  45              


Val Pro Pro Arg Arg Gln Arg Met Cys Ile Asn Asn Leu Glu Lys Leu 
    50                  55                  60                  


Asn Val Asp Lys Ile Arg Asp Lys His Ala Phe Leu Ala Asp Val Leu 
65                  70                  75                  80  


Leu Thr Ala Arg Asn Glu Gly Glu Arg Ile Val Gln Asn His Pro Asp 
                85                  90                  95      


Thr Asn Ser Ser Asn Val Cys Asn Ala Leu Glu Arg Ser Phe Ala Asp 
            100                 105                 110         


Ile Ala Asp Ile Ile Arg Gly Thr Asp Leu Trp Lys Gly Thr Asn Ser 
        115                 120                 125             


Asn Leu Glu Gln Asn Leu Lys Gln Met Phe Ala Lys Ile Arg Glu Asn 
    130                 135                 140                 


Asp Lys Val Leu Gln Asp Lys Tyr Pro Lys Asp Gln Asn Tyr Arg Lys 
145                 150                 155                 160 


Leu Arg Glu Asp Trp Trp Asn Ala Asn Arg Gln Lys Val Trp Glu Val 
                165                 170                 175     


Ile Thr Cys Gly Ala Arg Ser Asn Asp Leu Leu Ile Lys Arg Gly Trp 
            180                 185                 190         


Arg Thr Ser Gly Lys Ser Asn Gly Asp Asn Lys Leu Glu Leu Cys Arg 
        195                 200                 205             


Lys Cys Gly His Tyr Glu Glu Lys Val Pro Thr Lys Leu Asp Tyr Val 
    210                 215                 220                 


Pro Gln Phe Leu Arg Trp Leu Thr Glu Trp Ile Glu Asp Phe Tyr Arg 
225                 230                 235                 240 


Glu Lys Gln Asn Leu Ile Asp Asp Met Glu Arg His Arg Glu Glu Cys 
                245                 250                 255     


Thr Ser Glu Asp His Lys Ser Lys Glu Gly Thr Ser Tyr Cys Ser Thr 
            260                 265                 270         


Cys Lys Asp Lys Cys Lys Lys Tyr Cys Glu Cys Val Lys Lys Trp Lys 
        275                 280                 285             


Ser Glu Trp Glu Asn Gln Lys Asn Lys Tyr Thr Glu Leu Tyr Gln Gln 
    290                 295                 300                 


Asn Lys Asn Glu Thr Ser Gln Lys Asn Thr Ser Arg Tyr Asp Asp Tyr 
305                 310                 315                 320 


Val Lys Asp Phe Phe Lys Lys Leu Glu Ala Asn Tyr Ser Ser Leu Glu 
                325                 330                 335     


Asn Tyr Ile Lys Gly Asp Pro Tyr Phe Ala Glu Tyr Ala Thr Lys Leu 
            340                 345                 350         


Ser Phe Ile Leu Asn Ser Ser Asp Ala Asn Asn Pro Ser Glu Lys Ile 
        355                 360                 365             


Gln Lys Asn Asn Asp Glu Val Cys Asn Cys Asn Glu Ser Gly Ile Ala 
    370                 375                 380                 


Ser Val Glu Gln Glu Gln Ile Ser Asp Pro Ser Ser Asn Lys Thr Cys 
385                 390                 395                 400 


Ile Thr His Ser Ser Ile Lys Ala Asn Lys Lys Lys Val Cys Lys His 
                405                 410                 415     


Val Lys Leu Gly Val Arg Glu Asn Asp Lys Asp Leu Arg Val Cys Val 
            420                 425                 430         


Ile Glu His Thr Ser Leu Ser Gly Val Glu Asn Cys Cys Cys Gln Asp 
        435                 440                 445             


Phe Leu Arg Ile Leu Gln Glu Asn Cys Ser Asp Asn Lys Ser Gly Ser 
    450                 455                 460                 


Ser Ser Asn Gly Ser Cys Asn Asn Lys Asn Gln Glu Ala Cys Glu Lys 
465                 470                 475                 480 


Asn Leu Glu Lys Val Leu Ala Ser Leu Thr Asn Cys Tyr Lys Cys Asp 
                485                 490                 495     


Lys Cys Lys Ser Glu Gln Ser Lys Lys Asn Asn Lys Asn Trp Ile Trp 
            500                 505                 510         


Lys Lys Ser Ser Gly Lys Glu Gly Gly Leu Gln Lys Glu Tyr Ala Asn 
        515                 520                 525             


Thr Ile Gly Leu Pro Pro Arg Thr Gln Ser Leu Cys Leu Val Val Cys 
    530                 535                 540                 


Leu Asp Glu Lys Gly Lys Lys Thr Gln Glu Leu Lys Asn Ile Arg Thr 
545                 550                 555                 560 


Asn Ser Glu Leu Leu Lys Glu Trp Ile Ile Ala Ala Phe His Glu Gly 
                565                 570                 575     


Lys Asn Leu Lys Pro Ser His Glu Lys Lys Asn Asp Asp Asn Gly Lys 
            580                 585                 590         


Lys Asn Asp Asp Asn Asn Ser Lys Leu Cys Lys Ala Leu Glu Tyr Ser 
        595                 600                 605             


Phe Ala Asp Tyr Gly Asp Leu Ile Lys Gly Thr Ser Ile Trp Asp Asn 
    610                 615                 620                 


Glu Tyr Thr Lys Asp Leu Glu Leu Asn Leu Gln Lys Ile Phe Gly Lys 
625                 630                 635                 640 


Leu Phe Arg Lys Tyr Ile Lys Lys Asn Asn Thr Ala Glu Gln Asp Thr 
                645                 650                 655     


Ser Tyr Ser Ser Leu Asp Glu Leu Arg Glu Ser Trp Trp Asn Thr Asn 
            660                 665                 670         


Lys Lys Tyr Ile Trp Leu Ala Met Lys His Gly Ala Gly Met Asn Ser 
        675                 680                 685             


Thr Thr Cys Cys Gly Asp Gly Ser Val Thr Gly Ser Gly Ser Ser Gly 
    690                 695                 700                 


Ser Val Thr Gly Ser Ser Asp Ser Gly Ser Thr Cys Asp Asp Ile Pro 
705                 710                 715                 720 


Thr Ile Asp Leu Ile Pro Gln Tyr Leu Arg Phe Leu Gln Glu Trp Val 
                725                 730                 735     


Glu His Phe Cys Lys Gln Arg Gln Glu Lys Val Lys Pro Val Ile Glu 
            740                 745                 750         


Asn Cys Lys Ser Cys Lys Asn Thr Ser Gly Glu Arg Lys Ile Gly Gly 
        755                 760                 765             


Thr Cys Asn Gly Glu Cys Lys Thr Glu Cys Lys Asn Lys Cys Glu Val 
    770                 775                 780                 


Tyr Lys Lys Phe Ile Glu Asp Cys Lys Gly Gly Asp Gly Thr Ala Gly 
785                 790                 795                 800 


Ser Ser Trp Val Lys Arg Trp Asp Gln Ile Tyr Lys Arg Tyr Ser Lys 
                805                 810                 815     


Tyr Ile Glu Asp Ala Lys Arg Asn Arg Lys Ala Gly Thr Lys Asn Cys 
            820                 825                 830         


Gly Pro Ser Ser Thr Thr Asn Ala Ala Glu Asn Lys Cys Val Gln Ser 
        835                 840                 845             


Asp Ile Asp Ser Phe Phe Lys His Leu Ile Asp Ile Gly Leu Thr Thr 
    850                 855                 860                 


Pro Ser Ser Tyr Leu Ser Ile Val Leu Asp Asp Asn Ile Cys Gly Ala 
865                 870                 875                 880 


Asp Lys Ala Pro Trp Thr Thr Tyr Thr Thr Tyr Thr Thr Thr Glu Lys 
                885                 890                 895     


Cys Asn Lys Glu Thr Asp Lys Ser Lys Leu Gln Gln Cys Asn Thr Ala 
            900                 905                 910         


Val Val Val Asn Val Pro Ser Pro Leu Gly Asn Thr Pro His Gly Tyr 
        915                 920                 925             


Lys Tyr Ala Cys Gln Cys Lys Ile Pro Thr Asn His His His His His 
    930                 935                 940                 


His Leu Glu His His His His His His 
945                 950             


