                         SEQUENCE LISTING

<110>  The University of Sydney
 
<120>  Thrombin inhibitors for treatment of stroke and related 
       coagulative disorders

<130>  50189913TPG

<150>  AU2016905231
<151>  2016-12-16

<160>  44    

<170>  PatentIn version 3.5

<210>  1a
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(6)
<223>  is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  is D, E, Q, S or P

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(14)
<223>  is D, E, Q, S or P

<400>  1a

Pro Xaa Tyr Xaa Xaa Xaa Glx Glx Pro Xaa Tyr Glx Glx Glx 
1               5                   10                  


<210>  1b
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  is D, E, Q, S or P

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  is D, E, Q, S or P

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  is D, E, Q, S or P

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  is D, E, Q, S or P

<220>
<221>  MISC_FEATURE
<222>  (9)..(11)
<223>  is any amino acid

<400>  1b

Glx Xaa Glx Tyr Glx Xaa Tyr Glx Xaa Xaa Xaa 
1               5                   10      


<210>  2
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  is K/ R/ H

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  is D/ E

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(14)
<223>  is D/ E

<400>  2

Pro Asx Tyr Xaa Xaa Gly Glx Glx Pro Xaa Tyr Glx Glx Glx 
1               5                   10                  


<210>  3
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  is A/T/S or G

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  is D/E

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  is S or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(14)
<223>  is D/E

<400>  3

Pro Gln Tyr Xaa Xaa Gly Glx Glx Pro Xaa Tyr Glx Glx Glx 
1               5                   10                  


<210>  4
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  is D/E

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  is S/T

<220>
<221>  MISC_FEATURE
<222>  (12)..(14)
<223>  is D/E

<400>  4

Pro Gln Tyr Ala Xaa Gly Glx Glx Pro Xaa Tyr Glx Glx Glx 
1               5                   10                  


<210>  5
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  is D/E

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  is S/T

<220>
<221>  MISC_FEATURE
<222>  (12)..(14)
<223>  is D/E

<220>
<221>  MISC_FEATURE
<222>  (15)..(18)
<223>  is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  is D/E

<220>
<221>  MISC_FEATURE
<222>  (20)..(21)
<223>  is any amino acid

<400>  5

Pro Gln Tyr Ala Xaa Gly Glx Glx Pro Xaa Tyr Glx Glx Glx Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Glx Xaa Xaa 
            20      


<210>  6
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  is D/E

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  is S/T

<220>
<221>  MISC_FEATURE
<222>  (12)..(14)
<223>  is D or E

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  is D/T

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  is D/G/F

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  is D/A

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  is S/D/E

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  is D/E

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  is K/P/S

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  is L/V

<400>  6

Pro Gln Tyr Ala Xaa Gly Glx Glx Pro Xaa Tyr Glx Glx Glx Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa 
            20      


<210>  7
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  is D/E

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  is S/T

<220>
<221>  MISC_FEATURE
<222>  (12)..(14)
<223>  is D/E

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  is K/P/S

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  is L/V

<400>  7

Pro Gln Tyr Ala Xaa Gly Glx Glx Pro Xaa Tyr Glx Glx Glx Asp Asp 
1               5                   10                  15      


Asp Asp Asp Xaa Xaa 
            20      


<210>  8
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  is D/E

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  is S/T

<220>
<221>  MISC_FEATURE
<222>  (12)..(14)
<223>  is D/E

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  is K/P/S

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  is L/V

<400>  8

Pro Gln Tyr Ala Xaa Gly Glx Glx Pro Xaa Tyr Glx Glx Glx Asp Asp 
1               5                   10                  15      


Asp Glu Glu Xaa Xaa 
            20      


<210>  8a
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  8a

Pro Gln Tyr Ala Pro Gly Asp Glu Pro Ser Tyr Asp Glu Asp 
1               5                   10                  


<210>  8b
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  8b

Pro Gln Tyr Ala Pro Gly Glu Glu Pro Ser Tyr Asp Glu Asp 
1               5                   10                  


<210>  8c
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  8c

Pro Gln Tyr Thr His Gly Glu Glu Pro Glu Tyr Asp Glu Asp 
1               5                   10                  


<210>  8d
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  8d

Pro Gln Tyr Ala Gln Gly Glu Glu Pro Thr Tyr Asp Glu Asp 
1               5                   10                  


<210>  8e
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  8e

Pro Gln Tyr Ala Arg Gly Asp Val Pro Thr Tyr Asp Glu Glu 
1               5                   10                  


<210>  10a
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  10a

Leu Thr Tyr Thr Asp 
1               5   


<210>  10b
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  10b

Val Val Tyr Thr Asp 
1               5   


<210>  10c
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  10c

Asp Pro Gly Arg Arg Leu Gly Glu 
1               5               


<210>  10d
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  10d

Val Ala Glu Pro Lys Met 
1               5       


<210>  10e
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  10e

Glu Ile Pro Gly Ile Arg 
1               5       


<210>  10f
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  10f

Pro Thr Ala Lys Pro Arg 
1               5       


<210>  10g
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  10g

Arg Ala Leu His Val Lys 
1               5       


<210>  10h
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  10h

Glu Pro Ala Lys Pro Arg 
1               5       


<210>  10i
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  10i

Pro Arg Gly Gly Pro Lys 
1               5       


<210>  10j
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  10j

Thr Leu Ile Ser Ala Arg 
1               5       


<210>  11a
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  11a

Asp Phe Glu Glu Ile Pro Glu Glu Tyr Leu Gln 
1               5                   10      


<210>  11b
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  11b

Glu Asp Tyr Ala Ala Ile Glu Ala Ser Leu Ser Glu Thr Phe 
1               5                   10                  


<210>  11c
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  11c

Pro Phe Asp Phe Glu Ala Ile Pro Glu Glu Tyr Leu Asp Asp Glu Ser 
1               5                   10                  15      


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  12

Asp Ala Asp Tyr Asp Glu Tyr Glu Glu Asp Gly 
1               5                   10      


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  13

Asp Gly Asp Tyr Asp Glu Tyr Asp Asn Asp Glu 
1               5                   10      


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  14

Gln Gly Asp Tyr Asp Glu Tyr Asp Gln Asp Glu 
1               5                   10      


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  15

Asp Ala Asp Tyr Asp Asp Tyr Asp Glu Glu Gly 
1               5                   10      


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  16

Asp Val Ser Tyr Asp Glu Tyr Glu Asp Asn Gly 
1               5                   10      


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  17

Gln Asp Asp Tyr Asp Glu Tyr Asp Ala Asp Glu 
1               5                   10      


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  18

Glu Thr Asp Tyr Asp Glu Tyr Glu Glu Asn Glu 
1               5                   10      


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  19

Glu Ser Asp Tyr Asp Thr Tyr Pro Asp Asp Asn 
1               5                   10      


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  20

Asp Asp Glu Tyr Asp Met Tyr Glu Ser Asp Gly 
1               5                   10      


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  21

Glu Thr Ser Tyr Glu Glu Tyr Pro Asp Asp Ser 
1               5                   10      


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  22

Glu Ser Asp Tyr Asp Thr Tyr Pro Asp Asp Asn 
1               5                   10      


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor

<400>  23

Glu Arg Asp Asp Glu Asp Tyr Asp Asn Ser Asn 
1               5                   10      


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  is D/E

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  is T/M/E/S/D/G/N/P

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  is D/E

<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  is D/E

<220>
<221>  MISC_FEATURE
<222>  (8)..(11)
<223>  is D/E

<400>  24

Glx Xaa Glx Tyr Glx Glx Tyr Glx Glx Glx Glx 
1               5                   10      


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  is D/E

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  is D/E

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  is D/E

<400>  25

Glx Ser Glx Tyr Glx Thr Tyr Pro Asp Asp Asn 
1               5                   10      


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  is D/E

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  is D/E

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  is D/E

<400>  26

Glx Asp Glx Tyr Glx Met Tyr Glu Ser Asp Gly 
1               5                   10      


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  is D/E

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  is D/E

<400>  27

Glx Thr Ser Tyr Glx Glu Tyr Pro Asp Asp Ser 
1               5                   10      


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin inhibitor


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  is D/E

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  is D/E

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  is D/E

<400>  28

Glx Ser Glx Tyr Glx Thr Tyr Pro Asp Asp Asn 
1               5                   10      


