                               SEQUENCE LISTING

<110> AKSTON BIOSCIENCES CORPORATION
 
<120> INSULIN-FC FUSIONS AND METHODS OF USE

<130> 116603-0130

<140> PCT/US2017/065456
<141> 2017-12-08

<150> 62/514,460
<151> 2017-06-02

<150> 62/514,449
<151> 2017-06-02

<150> 62/514,427
<151> 2017-06-02

<150> 62/432,268
<151> 2016-12-09

<160> 36    

<170> PatentIn version 3.5

<210> 1
<211> 1005
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa cgactggtgt ccactccttc       60

gtgaagcagc acctgtgcgg ccctcacctg gtggaagctc tgtatctcgt gtgcggcgag      120

cggggcttct tctacacccc caagtctcgg agagaggtgg aagatcccca ggtggaacag      180

ctggaactgg gcggctctcc tggcgatctg cagacactgg ccctggaagt ggcccggcag      240

aaacggggca tcgtggacca gtgctgcacc tccatctgct ccctgtacca gctggaaaac      300

tactgcaatg gtggaggcgg tggagtgccc agagattgtg gatgtaagcc ttgcatatgt      360

acagtcccag aagtatcatc tgtcttcatc ttccccccaa agcccaagga tgtgctcacc      420

attactctga ctcctaaggt cacgtgtgtt gtggtagaca tcagcaagga tgatcccgag      480

gtccagttca gctggtttgt agatgatgtg gaggtgcaca cagctcagac gcaaccccgg      540

gaggagcagt tcaacagcac tttccgctca gtcagtgaac ttcccatcat gcaccaggac      600

tggctcaatg gcaaggagtt caaatgcagg gtcaacagtg cagctttccc tgcccccatc      660

gagaaaacca tctccaaaac caaaggcaga ccgaaggctc cacaggtgta caccattcca      720

cctcccaagg agcagatggc caaggataaa gtcagtctga cctgcatgat aacagacttc      780

ttccctgaag acattactgt ggagtggcag tggaatgggc agccagcgga gaactacaag      840

aacactcagc ccatcatgga cacagatggc tcttacttcg tctacagcaa gctcaatgtg      900

cagaagagca actgggaggc aggaaatact ttcacctgct ctgtgttaca tgagggcctg      960

cacaaccacc atactgagaa gagcctctcc cactctcctg gttag                     1005


<210> 2
<211> 288
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Ala Ala Lys 
            20                  25                  30          


Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
        35                  40                  45              


Glu Asn Tyr Cys Asn Gly Gly Gly Gly Ala Gly Gly Gly Gly Asp Lys 
    50                  55                  60                  


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
65                  70                  75                  80  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                85                  90                  95      


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            100                 105                 110         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        115                 120                 125             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    130                 135                 140                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
145                 150                 155                 160 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                165                 170                 175     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            180                 185                 190         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        195                 200                 205             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    210                 215                 220                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
225                 230                 235                 240 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                245                 250                 255     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            260                 265                 270         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        275                 280                 285             


<210> 3
<211> 288
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ala 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Ala Ala Lys 
            20                  25                  30          


Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
        35                  40                  45              


Glu Asn Tyr Cys Asn Gly Gly Gly Gly Ala Gly Gly Gly Gly Asp Lys 
    50                  55                  60                  


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
65                  70                  75                  80  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                85                  90                  95      


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            100                 105                 110         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        115                 120                 125             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    130                 135                 140                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
145                 150                 155                 160 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                165                 170                 175     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            180                 185                 190         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        195                 200                 205             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    210                 215                 220                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
225                 230                 235                 240 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                245                 250                 255     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            260                 265                 270         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        275                 280                 285             


<210> 4
<211> 288
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Gln Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Ala Ala Lys 
            20                  25                  30          


Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
        35                  40                  45              


Glu Asn Tyr Cys Asn Gly Gly Gly Gly Ala Gly Gly Gly Gly Asp Lys 
    50                  55                  60                  


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
65                  70                  75                  80  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                85                  90                  95      


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            100                 105                 110         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        115                 120                 125             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    130                 135                 140                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
145                 150                 155                 160 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                165                 170                 175     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            180                 185                 190         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        195                 200                 205             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    210                 215                 220                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
225                 230                 235                 240 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                245                 250                 255     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            260                 265                 270         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        275                 280                 285             


<210> 5
<211> 288
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Glu Gly Phe Phe Tyr Thr Pro Lys Ala Ala Lys 
            20                  25                  30          


Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
        35                  40                  45              


Glu Asn Tyr Cys Asn Gly Gly Gly Gly Ala Gly Gly Gly Gly Asp Lys 
    50                  55                  60                  


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
65                  70                  75                  80  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                85                  90                  95      


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            100                 105                 110         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        115                 120                 125             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    130                 135                 140                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
145                 150                 155                 160 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                165                 170                 175     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            180                 185                 190         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        195                 200                 205             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    210                 215                 220                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
225                 230                 235                 240 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                245                 250                 255     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            260                 265                 270         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        275                 280                 285             


<210> 6
<211> 288
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ala 
1               5                   10                  15      


Leu Val Cys Gly Glu Glu Gly Phe Phe Tyr Thr Pro Lys Ala Ala Lys 
            20                  25                  30          


Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
        35                  40                  45              


Glu Asn Tyr Cys Asn Gly Gly Gly Gly Ala Gly Gly Gly Gly Asp Lys 
    50                  55                  60                  


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
65                  70                  75                  80  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                85                  90                  95      


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            100                 105                 110         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        115                 120                 125             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    130                 135                 140                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
145                 150                 155                 160 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                165                 170                 175     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            180                 185                 190         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        195                 200                 205             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    210                 215                 220                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
225                 230                 235                 240 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                245                 250                 255     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            260                 265                 270         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        275                 280                 285             


<210> 7
<211> 279
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ala 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Ala Ala Lys 
            20                  25                  30          


Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
        35                  40                  45              


Glu Asn Tyr Cys Asn Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
    50                  55                  60                  


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
65                  70                  75                  80  


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                85                  90                  95      


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            100                 105                 110         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        115                 120                 125             


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    130                 135                 140                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
145                 150                 155                 160 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                165                 170                 175     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
            180                 185                 190         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        195                 200                 205             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    210                 215                 220                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
225                 230                 235                 240 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                245                 250                 255     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            260                 265                 270         


Ser Leu Ser Leu Ser Pro Gly 
        275                 


<210> 8
<211> 288
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ala 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Ala Ala Lys 
            20                  25                  30          


Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
        35                  40                  45              


Glu Asn Tyr Cys Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Asp Lys 
    50                  55                  60                  


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
65                  70                  75                  80  


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                85                  90                  95      


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            100                 105                 110         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        115                 120                 125             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    130                 135                 140                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
145                 150                 155                 160 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                165                 170                 175     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            180                 185                 190         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        195                 200                 205             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    210                 215                 220                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
225                 230                 235                 240 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                245                 250                 255     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            260                 265                 270         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        275                 280                 285             


<210> 9
<211> 289
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ala 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Ala Ala Ala 
            20                  25                  30          


Lys Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
        35                  40                  45              


Leu Glu Asn Tyr Cys Asn Gly Gly Gly Gly Ala Gly Gly Gly Gly Asp 
    50                  55                  60                  


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    130                 135                 140                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly 
    


<210> 10
<211> 290
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ala 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Ala Ala Ala 
            20                  25                  30          


Ala Lys Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr 
        35                  40                  45              


Gln Leu Glu Asn Tyr Cys Asn Gly Gly Gly Gly Ala Gly Gly Gly Gly 
    50                  55                  60                  


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
65                  70                  75                  80  


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                85                  90                  95      


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            100                 105                 110         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        115                 120                 125             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    130                 135                 140                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
145                 150                 155                 160 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                165                 170                 175     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            180                 185                 190         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        195                 200                 205             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    210                 215                 220                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
225                 230                 235                 240 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                245                 250                 255     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            260                 265                 270         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        275                 280                 285             


Pro Gly 
    290 


<210> 11
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 
            20                  25                  


<210> 12
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ala 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 
            20                  25                  


<210> 13
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Gln Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys 
            20                  25                  


<210> 14
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Glu Gly Phe Phe Tyr Thr Pro Lys 
            20                  25                  


<210> 15
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Ala 
1               5                   10                  15      


Leu Val Cys Gly Glu Glu Gly Phe Phe Tyr Thr Pro Lys 
            20                  25                  


<210> 16
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Ala Ala Lys 
1           


<210> 17
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Ala Ala Ala Lys 
1               


<210> 18
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Ala Ala Ala Ala Lys 
1               5   


<210> 19
<211> 21
<212> PRT
<213> Homo sapiens

<400> 19
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210> 20
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Gly Gly Gly Gly Ala Gly Gly Gly Gly 
1               5                   


<210> 21
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   


<210> 22
<211> 226
<212> PRT
<213> Homo sapiens

<400> 22
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210> 23
<211> 227
<212> PRT
<213> Homo sapiens

<400> 23
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210> 24
<211> 86
<212> PRT
<213> Homo sapiens

<400> 24
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210> 25
<211> 30
<212> PRT
<213> Homo sapiens

<400> 25
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210> 26
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210> 27
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa cgactggtgt ccactcc          57


<210> 28
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (13)..(13)
<223> Glu or Gln 

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Tyr or Ala 

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Arg or Glu 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 28
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Xaa Ala Leu Xaa 
1               5                   10                  15      


Leu Val Cys Gly Glu Xaa Gly Phe Phe Tyr Thr Pro Lys 
            20                  25                  


<210> 29
<211> 924
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 29
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa cgactggtgt ccactccttc       60

gtgaaccagc acctgtgcgg ctcccacctg gtggaagctc tggctctcgt gtgcggcgag      120

cggggcttct tctacacccc caaggccgct aaaggcatcg tggaacagtg ctgcacctcc      180

atctgctccc tgtaccagct ggaaaactac tgcaatggcg gaggtggtgc aggaggcggt      240

ggagacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      300

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      360

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      420

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      480

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      540

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      600

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc      660

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg      720

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac      780

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag      840

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag      900

agcctctccc tgtctccggg ttag                                             924


<210> 30
<211> 924
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 30
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa cgactggtgt ccactccttc       60

gtgaaccagc acctgtgcgg ctcccacctg gtgcaagctc tgtatctcgt gtgcggcgag      120

cggggcttct tctacacccc caaggccgct aaaggcatcg tggaacagtg ctgcacctcc      180

atctgctccc tgtaccagct ggaaaactac tgcaatggcg gaggtggtgc aggaggcggt      240

ggagacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      300

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      360

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      420

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      480

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      540

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      600

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc      660

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg      720

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac      780

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag      840

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag      900

agcctctccc tgtctccggg ttag                                             924


<210> 31
<211> 924
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 31
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa cgactggtgt ccactccttc       60

gtgaaccagc acctgtgcgg ctcccacctg gtggaagctc tgtatctcgt gtgcggcgag      120

gagggcttct tctacacccc caaggccgct aaaggcatcg tggaacagtg ctgcacctcc      180

atctgctccc tgtaccagct ggaaaactac tgcaatggcg gaggtggtgc aggaggcggt      240

ggagacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      300

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      360

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      420

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      480

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      540

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      600

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc      660

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg      720

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac      780

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag      840

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag      900

agcctctccc tgtctccggg ttag                                             924


<210> 32
<211> 924
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 32
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa cgactggtgt ccactccttc       60

gtgaaccagc acctgtgcgg ctcccacctg gtggaagctc tggctctcgt gtgcggcgag      120

gagggcttct tctacacccc caaggccgct aaaggcatcg tggaacagtg ctgcacctcc      180

atctgctccc tgtaccagct ggaaaactac tgcaatggcg gaggtggtgc aggaggcggt      240

ggagacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      300

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      360

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      420

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      480

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      540

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      600

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc      660

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg      720

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac      780

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag      840

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag      900

agcctctccc tgtctccggg ttag                                             924


<210> 33
<211> 897
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 33
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa cgactggtgt ccactccttc       60

gtgaaccagc acctgtgcgg ctcccacctg gtggaagctc tggctctcgt gtgcggcgag      120

cggggcttct tctacacccc caaggccgct aaaggcatcg tggaacagtg ctgcacctcc      180

atctgctccc tgtaccagct ggaaaactac tgcaatgaca aaactcacac atgcccaccg      240

tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag      300

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      360

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      420

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc      480

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc      540

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg      600

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg      660

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag      720

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc      780

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg      840

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggttag         897


<210> 34
<211> 924
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 34
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa cgactggtgt ccactccttc       60

gtgaaccagc acctgtgcgg ctcccacctg gtggaagctc tggctctcgt gtgcggcgag      120

cggggcttct tctacacccc caaggccgct aaaggcatcg tggaacagtg ctgcacctcc      180

atctgctccc tgtaccagct ggaaaactac tgcaatggcg gaggtggttc aggaggcggt      240

ggagacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      300

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      360

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      420

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      480

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      540

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      600

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc      660

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg      720

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac      780

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag      840

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag      900

agcctctccc tgtctccggg ttag                                             924


<210> 35
<211> 927
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 35
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa cgactggtgt ccactccttc       60

gtgaaccagc acctgtgcgg ctcccacctg gtggaagctc tggctctcgt gtgcggcgag      120

cggggcttct tctacacccc caaggccgct gcaaaaggca tcgtggaaca gtgctgcacc      180

tccatctgct ccctgtacca gctggaaaac tactgcaatg gcggaggtgg tgcaggaggc      240

ggtggagaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      300

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      360

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      420

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      480

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      540

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa      600

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg      660

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc      720

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg      780

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag      840

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag      900

aagagcctct ccctgtctcc gggttag                                          927


<210> 36
<211> 930
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 36
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa cgactggtgt ccactccttc       60

gtgaaccagc acctgtgcgg ctcccacctg gtggaagctc tggctctcgt gtgcggcgag      120

cggggcttct tctacacccc caaggccgct gcagctaaag gcatcgtgga acagtgctgc      180

acctccatct gctccctgta ccagctggaa aactactgca atggcggagg tggtgcagga      240

ggcggtggag acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      300

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      360

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      420

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      480

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      540

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      600

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      660

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      720

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      780

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      840

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      900

cagaagagcc tctccctgtc tccgggttag                                       930


