                         SEQUENCE LISTING

<110>  H. Lee Moffitt Cancer Center and Research, Inc.
 
<120>  TLR9-BINDING CHIMERIC ANTIGEN RECEPTORS

<130>  320803-2130

<150>  US 62/432,325
<151>  2016-12-09

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1

Thr Ala Gly Met Gln 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Trp Ile Asn Thr His Ser Gly Glu Pro Lys Tyr Ala Glu Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Gly Asp Ser Ser Gly Tyr Gly Ala Trp Phe Ala Tyr 
1               5                   10          


<210>  4
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Asp Thr Asn Asn Arg Ala Pro 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Ala Leu Trp Cys Ser Asn His Trp Val 
1               5                   


<210>  7
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Ala 
            20                  25                  30          


Gly Met Gln Trp Tyr Gln Lys Met Pro Gly Lys Gly Phe Lys Trp Ile 
        35                  40                  45              


Gly Trp Ile Asn Thr His Ser Gly Glu Pro Lys Tyr Ala Glu Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Ser Ser Gly Tyr Gly Ala Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala Ala 
        115                 120         


<210>  8
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Asp Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Cys Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  9
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Asp Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Cys Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  10
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Asp Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Cys Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  11
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  13
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Met Val Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  14
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Met Val Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
            20                  25                  30          


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Thr Ala Gly Met Gln Trp Tyr Gln Lys Met Pro Gly 
    50                  55                  60                  


Lys Gly Phe Lys Trp Ile Gly Trp Ile Asn Thr His Ser Gly Glu Pro 
65                  70                  75                  80  


Lys Tyr Ala Glu Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr 
                85                  90                  95      


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp 
            100                 105                 110         


Thr Ala Thr Tyr Phe Cys Ala Arg Gly Asp Ser Ser Gly Tyr Gly Ala 
        115                 120                 125             


Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala 
    130                 135                 140                 


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
145                 150                 155                 160 


Lys Gly Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro 
                165                 170                 175     


Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr 
            180                 185                 190         


Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe 
        195                 200                 205             


Thr Gly Leu Ile Gly Asp Thr Asn Asn Arg Ala Pro Gly Val Pro Ala 
    210                 215                 220                 


Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr 
225                 230                 235                 240 


Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Cys 
                245                 250                 255     


Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            260                 265                 270     


<210>  15
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Met Val Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Ala Val Val Thr Gln Glu Ser Ala Leu 
            20                  25                  30          


Thr Thr Ser Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr 
        35                  40                  45              


Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro 
    50                  55                  60                  


Asp His Leu Phe Thr Gly Leu Ile Gly Asp Thr Asn Asn Arg Ala Pro 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala 
                85                  90                  95      


Leu Thr Ile Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys 
            100                 105                 110         


Ala Leu Trp Cys Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Thr Val Leu Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu 
    130                 135                 140                 


Gly Ser Thr Lys Gly Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr 
145                 150                 155                 160 


Thr Ser Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly 
                165                 170                 175     


Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp 
            180                 185                 190         


His Leu Phe Thr Gly Leu Ile Gly Asp Thr Asn Asn Arg Ala Pro Gly 
        195                 200                 205             


Val Pro Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu 
    210                 215                 220                 


Thr Ile Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala 
225                 230                 235                 240 


Leu Trp Cys Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
                245                 250                 255     


Val Leu 
        


<210>  16
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Met Val Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
            20                  25                  30          


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Thr Ala Gly Met Gln Trp Tyr Gln Lys Met Pro Gly 
    50                  55                  60                  


Lys Gly Phe Lys Trp Ile Gly Trp Ile Asn Thr His Ser Gly Glu Pro 
65                  70                  75                  80  


Lys Tyr Ala Glu Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr 
                85                  90                  95      


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp 
            100                 105                 110         


Thr Ala Thr Tyr Phe Cys Ala Arg Gly Asp Ser Ser Gly Tyr Gly Ala 
        115                 120                 125             


Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
145                 150                 155                 160 


Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu Thr 
                165                 170                 175     


Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn 
            180                 185                 190         


Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly Leu 
        195                 200                 205             


Ile Gly Asp Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln 
225                 230                 235                 240 


Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Cys Ser Asn His 
                245                 250                 255     


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            260                 265             


<210>  17
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Met Val Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Ala Val Val Thr Gln Glu Ser Ala Leu 
            20                  25                  30          


Thr Thr Ser Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr 
        35                  40                  45              


Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro 
    50                  55                  60                  


Asp His Leu Phe Thr Gly Leu Ile Gly Asp Thr Asn Asn Arg Ala Pro 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala 
                85                  90                  95      


Leu Thr Ile Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys 
            100                 105                 110         


Ala Leu Trp Cys Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro 
145                 150                 155                 160 


Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr 
                165                 170                 175     


Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe 
            180                 185                 190         


Thr Gly Leu Ile Gly Asp Thr Asn Asn Arg Ala Pro Gly Val Pro Ala 
        195                 200                 205             


Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr 
    210                 215                 220                 


Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Cys 
225                 230                 235                 240 


Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250                 255 


<210>  18
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
1               5                   10                  15      


Gly Ile Ala Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            20                  25                  30          


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        35                  40                  45              


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    50                  55                  60                  


Tyr Ser Lys Leu Thr Val Leu Gly Arg Arg Trp Thr Leu Gly Asn Val 
65                  70                  75                  80  


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                85                  90                  95      


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105 


<210>  19
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
1               5                   10                  15      


Leu Pro Cys Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            20                  25                  30          


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        35                  40                  45              


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Tyr 
    50                  55                  60                  


Ser Lys Leu Thr Val Phe Cys Pro Arg Trp Leu Gly Gly Asn Val Phe 
65                  70                  75                  80  


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                85                  90                  95      


Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 


<210>  20
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
1               5                   10                  15      


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            20                  25                  30          


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        35                  40                  45              


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    50                  55                  60                  


Tyr Ser Lys Leu Thr Val Pro Cys Met Arg Trp Trp Gly Gly Asn Val 
65                  70                  75                  80  


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                85                  90                  95      


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105 


<210>  21
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
1               5                   10                  15      


Gly Ile Ala Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            20                  25                  30          


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        35                  40                  45              


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    50                  55                  60                  


Tyr Ser Lys Leu Thr Val Leu Gly Arg Arg Trp Thr Leu Gly Asn Val 
65                  70                  75                  80  


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                85                  90                  95      


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Pro Arg Glu Pro Gln Val Tyr Thr 
        115                 120                 125             


Leu Pro Pro Ser Arg Asp Glu Leu Leu Pro Cys Gln Val Ser Leu Thr 
    130                 135                 140                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
145                 150                 155                 160 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                165                 170                 175     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Phe Cys 
            180                 185                 190         


Pro Arg Trp Leu Gly Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        195                 200                 205             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220                 


Lys 
225 


<210>  22
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
1               5                   10                  15      


Gly Ile Ala Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            20                  25                  30          


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        35                  40                  45              


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    50                  55                  60                  


Tyr Ser Lys Leu Thr Val Leu Gly Arg Arg Trp Thr Leu Gly Asn Val 
65                  70                  75                  80  


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                85                  90                  95      


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Pro Arg Glu Pro Gln Val Tyr Thr 
        115                 120                 125             


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    130                 135                 140                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
145                 150                 155                 160 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                165                 170                 175     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Pro Cys 
            180                 185                 190         


Met Arg Trp Trp Gly Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        195                 200                 205             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220                 


Lys 
225 


<210>  23
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23

Met Val Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            20                  25                  30          


Pro Ser Arg Asp Glu Leu Gly Ile Ala Gln Val Ser Leu Thr Cys Leu 
        35                  40                  45              


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    50                  55                  60                  


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
65                  70                  75                  80  


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Leu Gly Arg Arg 
                85                  90                  95      


Trp Thr Leu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            100                 105                 110         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Leu Pro 
145                 150                 155                 160 


Cys Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            180                 185                 190         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Lys Leu Thr Val Phe Cys Pro Arg Trp Leu Gly Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Lys 
                245         


<210>  24
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Met Val Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            20                  25                  30          


Pro Ser Arg Asp Glu Leu Gly Ile Ala Gln Val Ser Leu Thr Cys Leu 
        35                  40                  45              


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    50                  55                  60                  


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
65                  70                  75                  80  


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Leu Gly Arg Arg 
                85                  90                  95      


Trp Thr Leu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            100                 105                 110         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
145                 150                 155                 160 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            180                 185                 190         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Lys Leu Thr Val Pro Cys Met Arg Trp Trp Gly Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Lys 
                245         


<210>  25
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25

Met Val Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            20                  25                  30          


Pro Ser Arg Asp Glu Leu Gly Ile Ala Gln Val Ser Leu Thr Cys Leu 
        35                  40                  45              


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    50                  55                  60                  


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
65                  70                  75                  80  


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Leu Gly Arg Arg 
                85                  90                  95      


Trp Thr Leu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            100                 105                 110         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Leu Pro 
145                 150                 155                 160 


Cys Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            180                 185                 190         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Lys Leu Thr Val Phe Cys Pro Arg Trp Leu Gly Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro 
                245                 250                 255     


Gly Ser Gly Glu Gly Ser Thr Lys Gly 
            260                 265 


<210>  26
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Met Val Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            20                  25                  30          


Pro Ser Arg Asp Glu Leu Gly Ile Ala Gln Val Ser Leu Thr Cys Leu 
        35                  40                  45              


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    50                  55                  60                  


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
65                  70                  75                  80  


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Leu Gly Arg Arg 
                85                  90                  95      


Trp Thr Leu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            100                 105                 110         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
145                 150                 155                 160 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            180                 185                 190         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Lys Leu Thr Val Pro Cys Met Arg Trp Trp Gly Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro 
                245                 250                 255     


Gly Ser Gly Glu Gly Ser Thr Lys Gly 
            260                 265 


<210>  27
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    50                  55                  60                  


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
65                  70                  75                  80  


His Arg Asn Arg 
                


<210>  28
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  29
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29

Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
1               5                   10                  15      


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
            20                  25                  30          


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40                  45          


<210>  30
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  31
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  31

Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp Lys 
1               5                   10                  15      


Pro Ser Leu Ser Ala Arg Tyr Val 
            20                  


<210>  32
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    50                  55                  60                  


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
65                  70                  75                  80  


His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys 
                85                  90                  95      


Ser Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
            100                 105             


<210>  33
<211>  435
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33
atggtcctcc tggttacctc tctgcttctg tgcgaactgc ctcatcctgc cttccttctt       60

ataccgcccc gcgagccaca ggtgtatact cttcctccct caagggacga actcggcatc      120

gcccaagtca gcctgacgtg tcttgtgaaa gggttttacc ccagcgatat cgccgtggag      180

tgggaaagca acggccagcc tgagaacaat tataagacta cccctcccgt actggactct      240

gacggcagtt tctttctcta ttctaaactg accgtgctcg gaaggcgctg gacgctcggc      300

aacgtatttt cttgcagtgt gatgcatgaa gcactgcaca atcattatac tcagaagagc      360

ttgtcactgt ccccgggaaa gggcagcaca tccggcagcg ggaaaccggg tagcggcgaa      420

gggagcacta agggg                                                       435


<210>  34
<211>  435
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34
atggtgctgc tcgttacaag tctgcttctc tgtgaactgc cgcatccggc ctttcttttg       60

atcccgccaa gggaacccca ggtttacaca ctgcccccat cccgggacga gttgctgcct      120

tgtcaggtga gtcttacatg cttggtgaag ggcttttacc cgtctgacat agcagtggaa      180

tgggagtcca acggacagcc agaaaataac tacaagacca cccctcccgt ccttgacagc      240

gatggaagct tttttctgta tagcaagctg actgtgttct gtcctagatg gctggggggc      300

aatgtttttt cttgcagcgt catgcacgaa gccctccaca accactacac ccagaaaagc      360

ctgtccttgt ctcctggcaa gggtagcaca tcaggtagcg gcaagcccgg gagtggcgag      420

ggcagtacca agggc                                                       435


<210>  35
<211>  435
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35
atggttctgc tcgttacatc tcttctgctc tgcgaactgc cacatccggc gttcctcctt       60

attccaccgc gagaacctca ggtttacacc ctccccccta gcagggacga gctgactaaa      120

aatcaagtat cattgacctg tctggttaag ggcttttatc cgtccgatat tgctgttgag      180

tgggaatcta acggccaacc tgagaacaat tataaaacta cgccgccggt actcgactct      240

gacggcagct tcttcctcta ctctaaactc actgtacctt gcatgagatg gtgggggggt      300

aatgttttta gctgctccgt gatgcatgag gccctccaca accattacac gcagaagtct      360

ctcagcctca gtcccggcaa gggctctacg tcaggctcag gcaaaccggg aagtggggaa      420

ggatcaacta aggga                                                       435


<210>  36
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36
atggttctgt tggtgacttc tcttcttttg tgcgagctcc cacatcctgc gttccttttg       60

attccgccga gggagcccca agtttatacc ctgcctccta gtcgggatga gttgggtatc      120

gcacaagtga gcctgacttg tctcgtaaag ggattctatc cgtccgatat agcagtcgag      180

tgggaaagta atgggcagcc ggagaacaac tacaagacaa ctcccccagt tcttgactcc      240

gacggatcat tttttttgta ctctaaattg acggtcctgg gtaggcgctg gaccctcggc      300

aatgtcttca gttgtagcgt aatgcatgaa gcccttcaca accattatac ccagaagagt      360

ttgtcccttt ctcccggtaa ggggggagga ggttctggag gtggaggtag cggtggtggg      420

ggttccccac gagagcccca agtgtacact ctcccaccgt ctcgggatga attgcttccg      480

tgccaggtat cccttacttg cctcgttaaa gggttctacc caagcgacat tgcggtggaa      540

tgggaatcaa atggtcagcc agaaaacaat tacaagacga cccctccagt cctcgactca      600

gatggatctt tctttctgta ttccaagctg acggtttttt gtccgaggtg gcttggaggg      660

aacgtcttct catgctccgt catgcacgag gcgctgcata accactacac acagaaaagt      720

ttgtccttga gcccgggtaa aggcagcacc agcgggagcg gaaaacctgg aagtggggaa      780

gggtctacca agggc                                                       795


<210>  37
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37
atggttctgc tggtaacctc cctccttctg tgcgagctcc cccaccccgc attcctcctg       60

attccgccca gagaacccca ggtgtatacc cttcccccta gcagagatga gctgggcata      120

gctcaggtat ccctcacatg cctcgtgaaa ggattctacc caagtgacat cgccgtggag      180

tgggaaagca acgggcagcc ggaaaacaat tataagacga ccccacccgt gctcgacagt      240

gacggctctt tcttcctgta ctccaaactg accgtccttg gacggcgatg gacactgggc      300

aatgttttta gctgttccgt gatgcatgag gccctgcaca accactatac ccagaagtca      360

ctctctctgt ctcctgggaa aggagggggt ggcagcggcg gtggcggatc tggcggagga      420

ggttctccca gggagcctca ggtatatacc ctgccccctt ctcgcgacga gttgacgaag      480

aaccaagtgt ctctgacctg cctggtcaaa ggattctacc cttctgatat tgcagtggaa      540

tgggaatcca acgggcagcc tgagaataat tacaagacca ccccacctgt tcttgatagt      600

gacggttcat tcttcctcta cagcaagctg accgtgccct gtatgaggtg gtggggcggc      660

aacgtctttt cttgttccgt catgcacgaa gcactgcata accactacac ccagaaaagc      720

ctgtctctta gccctgggaa gggatctacc tcaggatctg ggaaacctgg tagcggcgag      780

ggtagcacca aagga                                                       795


<210>  38
<211>  261
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38
ttcgtgccgg tcttcctgcc agcgaagccc accacgacgc cagcgccgcg accaccaaca       60

ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg ccggccagcg      120

gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg      180

cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaac      240

cacaggaaca ggagtaagag g                                                261


<210>  39
<211>  194
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39
aagttatgta tcctcctcct tacctagaca atgagaagag caatggaacc attatccatg       60

tgaaagggaa acacctttgt ccaagtcccc tatttcccgg accttctaag cccttttggg      120

tgctggtggt ggttggggga gtcctggctt gctatagctt gctagtaaca gtggccttta      180

ttattttctg ggtg                                                        194


<210>  40
<211>  141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40
cgtttctctg ttgttaaacg gggcagaaag aaactcctgt atatattcaa acaaccattt       60

atgagaccag tacaaactac tcaagaggaa gatggctgta gctgccgatt tccagaagaa      120

gaagaaggag gatgtgaact g                                                141


<210>  41
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgctaa                             339


