                               SEQUENCE LISTING

<110> THE GENERAL HOSPITAL CORPORATION
 
<120> METHODS AND COMPOSITIONS RELATING TO ACTIVATION OF THE 
      INFLAMMASOME FOR THE TREATMENT OF TUMORS

<130> 030258-088541-PCT

<140>
<141>

<150> 62/431,037
<151> 2016-12-07

<160> 22    

<170> PatentIn version 3.5

<210> 1
<211> 782
<212> DNA
<213> Homo sapiens

<400> 1
gtccaggttc cgccccggag ccgacttcct cctggtcggc ggctgcagcg gggtgagcgg       60

cggcagcggc cggggatcct ggagccatgg ggcgcgcgcg cgacgccatc ctggatgcgc      120

tggagaacct gaccgccgag gagctcaaga agttcaagct gaagctgctg tcggtgccgc      180

tgcgcgaggg ctacgggcgc atcccgcggg gcgcgctgct gtccatggac gccttggacc      240

tcaccgacaa gctggtcagc ttctacctgg agacctacgg cgccgagctc accgctaacg      300

tgctgcgcga catgggcctg caggagatgg ccgggcagct gcaggcggcc acgcaccagg      360

gctctggagc cgcgccagct gggatccagg cccctcctca gtcggcagcc aagccaggcc      420

tgcactttat agaccagcac cgggctgcgc ttatcgcgag ggtcacaaac gttgagtggc      480

tgctggatgc tctgtacggg aaggtcctga cggatgagca gtaccaggca gtgcgggccg      540

agcccaccaa cccaagcaag atgcggaagc tcttcagttt cacaccagcc tggaactgga      600

cctgcaagga cttgctcctc caggccctaa gggagtccca gtcctacctg gtggaggacc      660

tggagcggag ctgaggctcc ttcccagcaa cactccggtc agcccctggc aatcccacca      720

aatcatcctg aatctgatct ttttatacac aatatacgaa aagccagctt gaaaaaaaaa      780

aa                                                                     782


<210> 2
<211> 725
<212> DNA
<213> Homo sapiens

<400> 2
gtccaggttc cgccccggag ccgacttcct cctggtcggc ggctgcagcg gggtgagcgg       60

cggcagcggc cggggatcct ggagccatgg ggcgcgcgcg cgacgccatc ctggatgcgc      120

tggagaacct gaccgccgag gagctcaaga agttcaagct gaagctgctg tcggtgccgc      180

tgcgcgaggg ctacgggcgc atcccgcggg gcgcgctgct gtccatggac gccttggacc      240

tcaccgacaa gctggtcagc ttctacctgg agacctacgg cgccgagctc accgctaacg      300

tgctgcgcga catgggcctg caggagatgg ccgggcagct gcaggcggcc acgcaccagg      360

gcctgcactt tatagaccag caccgggctg cgcttatcgc gagggtcaca aacgttgagt      420

ggctgctgga tgctctgtac gggaaggtcc tgacggatga gcagtaccag gcagtgcggg      480

ccgagcccac caacccaagc aagatgcgga agctcttcag tttcacacca gcctggaact      540

ggacctgcaa ggacttgctc ctccaggccc taagggagtc ccagtcctac ctggtggagg      600

acctggagcg gagctgaggc tccttcccag caacactccg gtcagcccct ggcaatccca      660

ccaaatcatc ctgaatctga tctttttata cacaatatac gaaaagccag cttgaaaaaa      720

aaaaa                                                                  725


<210> 3
<211> 195
<212> PRT
<213> Homo sapiens

<400> 3
Met Gly Arg Ala Arg Asp Ala Ile Leu Asp Ala Leu Glu Asn Leu Thr 
1               5                   10                  15      


Ala Glu Glu Leu Lys Lys Phe Lys Leu Lys Leu Leu Ser Val Pro Leu 
            20                  25                  30          


Arg Glu Gly Tyr Gly Arg Ile Pro Arg Gly Ala Leu Leu Ser Met Asp 
        35                  40                  45              


Ala Leu Asp Leu Thr Asp Lys Leu Val Ser Phe Tyr Leu Glu Thr Tyr 
    50                  55                  60                  


Gly Ala Glu Leu Thr Ala Asn Val Leu Arg Asp Met Gly Leu Gln Glu 
65                  70                  75                  80  


Met Ala Gly Gln Leu Gln Ala Ala Thr His Gln Gly Ser Gly Ala Ala 
                85                  90                  95      


Pro Ala Gly Ile Gln Ala Pro Pro Gln Ser Ala Ala Lys Pro Gly Leu 
            100                 105                 110         


His Phe Ile Asp Gln His Arg Ala Ala Leu Ile Ala Arg Val Thr Asn 
        115                 120                 125             


Val Glu Trp Leu Leu Asp Ala Leu Tyr Gly Lys Val Leu Thr Asp Glu 
    130                 135                 140                 


Gln Tyr Gln Ala Val Arg Ala Glu Pro Thr Asn Pro Ser Lys Met Arg 
145                 150                 155                 160 


Lys Leu Phe Ser Phe Thr Pro Ala Trp Asn Trp Thr Cys Lys Asp Leu 
                165                 170                 175     


Leu Leu Gln Ala Leu Arg Glu Ser Gln Ser Tyr Leu Val Glu Asp Leu 
            180                 185                 190         


Glu Arg Ser 
        195 


<210> 4
<211> 176
<212> PRT
<213> Homo sapiens

<400> 4
Met Gly Arg Ala Arg Asp Ala Ile Leu Asp Ala Leu Glu Asn Leu Thr 
1               5                   10                  15      


Ala Glu Glu Leu Lys Lys Phe Lys Leu Lys Leu Leu Ser Val Pro Leu 
            20                  25                  30          


Arg Glu Gly Tyr Gly Arg Ile Pro Arg Gly Ala Leu Leu Ser Met Asp 
        35                  40                  45              


Ala Leu Asp Leu Thr Asp Lys Leu Val Ser Phe Tyr Leu Glu Thr Tyr 
    50                  55                  60                  


Gly Ala Glu Leu Thr Ala Asn Val Leu Arg Asp Met Gly Leu Gln Glu 
65                  70                  75                  80  


Met Ala Gly Gln Leu Gln Ala Ala Thr His Gln Gly Leu His Phe Ile 
                85                  90                  95      


Asp Gln His Arg Ala Ala Leu Ile Ala Arg Val Thr Asn Val Glu Trp 
            100                 105                 110         


Leu Leu Asp Ala Leu Tyr Gly Lys Val Leu Thr Asp Glu Gln Tyr Gln 
        115                 120                 125             


Ala Val Arg Ala Glu Pro Thr Asn Pro Ser Lys Met Arg Lys Leu Phe 
    130                 135                 140                 


Ser Phe Thr Pro Ala Trp Asn Trp Thr Cys Lys Asp Leu Leu Leu Gln 
145                 150                 155                 160 


Ala Leu Arg Glu Ser Gln Ser Tyr Leu Val Glu Asp Leu Glu Arg Ser 
                165                 170                 175     


<210> 5
<211> 2326
<212> DNA
<213> Homo sapiens

<400> 5
cttccttgga gccccgccgc ccgccgctca ctctgcacac gcagcagaag ggacgtggtg       60

ttccccaggc tctggccccc caggacctgc gcggatctgg cccagggcgc ctcgccgact      120

tccgtaaact gggcggaggg atgaaccccg acccagggga cggaggcgct cgccctctcg      180

ctgcagggtt ctgccctcaa cacttctggc cccgcctgtg aatgggggcc ggagcgatgg      240

ggcggggccg gcctccctcc ctcctcccag gctgacctct gccctccttc gagcacttcc      300

cgttcggggt gatgattgaa gaactgagtg tggacagagc acctgtcctc gccagcgccc      360

agctggaagc tgagttattt gtggctgcag cattccaacg cacacaccac cagaaatccc      420

cttcagcata ctggcctcag acctaccagg gcagagacct tgtcttgttt gctgctagaa      480

cccaggatcg ctggaaaatc acctagcagc agccaggtgc ggtgactcac gcctgtaatc      540

ccagcacttt ggaaggccaa ggcgggtgga tagcaaggtc aagagatcga gaccagcctg      600

gccaacatgc tctgggcacc tccagctcct gctcgccgga cggctcccag ggagagcaga      660

cgcgccagac gcgccaccct cggggcgccg acggtcacgg agcatggggt cggcctttga      720

gcgggtagtc cggagagtgg tccaggagct ggaccatggt ggggagttca tccctgtgac      780

cagcctgcag agctccactg gcttccagcc ctactgcctg gtggttagga agccctcaag      840

ctcatggttc tggaaacccc gttataagtg tgtcaacctg tctatcaagg acatcctgga      900

gccggatgcc gcggaaccag acgtgcagcg tggcaggagc ttccacttct acgatgccat      960

ggatgggcag atacagggca gcgtggagct ggcagcccca ggacaggcaa agatcgcagg     1020

cggggccgcg gtgtctgaca gctccagcac ctcaatgaat gtgtactcgc tgagtgtgga     1080

ccctaacacc tggcagactc tgctccatga gaggcacctg cggcagccag aacacaaagt     1140

cctgcagcag ctgcgcagcc gcggggacaa cgtgtacgtg gtgactgagg tgctgcagac     1200

acagaaggag gtggaagtca cgcgcaccca caagcgggag ggctcgggcc ggttttccct     1260

gcccggagcc acgtgcttgc agggtgaggg ccagggccat ctgagccaga agaagacggt     1320

caccatcccc tcaggcagca ccctcgcatt ccgggtggcc cagctggtta ttgactctga     1380

cttggacgtc cttctcttcc cggataagaa gcagaggacc ttccagccac ccgcgacagg     1440

ccacaagcgt tccacgagcg aaggcgcctg gccacagctg ccctctggcc tctccatgat     1500

gaggtgcctc cacaacttcc tgacagatgg ggtccctgcg gagggggcgt tcactgaaga     1560

cttccagggc ctacgggcag aggtggagac catctccaag gaactggagc ttttggacag     1620

agagctgtgc cagctgctgc tggagggcct ggagggggtg ctgcgggacc agctggccct     1680

gcgagccttg gaggaggcgc tggagcaggg ccagagcctt gggccggtgg agcccctgga     1740

cggtccagca ggtgctgtcc tggagtgcct ggtgttgtcc tccggaatgc tggtgccgga     1800

actcgctatc cctgttgtct acctgctggg ggcactgacc atgctgagtg aaacgcagca     1860

caagctgctg gcggaggcgc tggagtcgca gaccctgttg gggccgctcg agctggtggg     1920

cagcctcttg gagcagagtg ccccgtggca ggagcgcagc accatgtccc tgccccccgg     1980

gctcctgggg aacagctggg gcgaaggagc accggcctgg gtcttgctgg acgagtgtgg     2040

cctagagctg ggggaggaca ctccccacgt gtgctgggag ccgcaggccc agggccgcat     2100

gtgtgcactc tacgcctccc tggcactgct atcaggactg agccaggagc cccactagcc     2160

tgtgcccggg catggcctgg cagctctcca gcagggcaga gtgtttgccc accagctgct     2220

agccctagga aggccaggag cccagtagcc atgtggccag tctaccatgg ggcccaggag     2280

ttggggaaac acaataaagg tggcatacga aggaaaaaaa aaaaaa                    2326


<210> 6
<211> 1772
<212> DNA
<213> Homo sapiens

<400> 6
gttccgggag ggcgtcctgg gcgggccctg cgtcaggttg cagtttcact tttagctctg       60

ggcacctcca gctcctgctc gccggacggc tcccagggag agcagacgcg ccagacgcgc      120

caccctcggg gcgccgacgg tcacggagca tggggtcggc ctttgagcgg gtagtccgga      180

gagtggtcca ggagctggac catggtgggg agttcatccc tgtgaccagc ctgcagagct      240

ccactggctt ccagccctac tgcctggtgg ttaggaagcc ctcaagctca tggttctgga      300

aaccccgtta taagtgtgtc aacctgtcta tcaaggacat cctggagccg gatgccgcgg      360

aaccagacgt gcagcgtggc aggagcttcc acttctacga tgccatggat gggcagatac      420

agggcagcgt ggagctggca gccccaggac aggcaaagat cgcaggcggg gccgcggtgt      480

ctgacagctc cagcacctca atgaatgtgt actcgctgag tgtggaccct aacacctggc      540

agactctgct ccatgagagg cacctgcggc agccagaaca caaagtcctg cagcagctgc      600

gcagccgcgg ggacaacgtg tacgtggtga ctgaggtgct gcagacacag aaggaggtgg      660

aagtcacgcg cacccacaag cgggagggct cgggccggtt ttccctgccc ggagccacgt      720

gcttgcaggg tgagggccag ggccatctga gccagaagaa gacggtcacc atcccctcag      780

gcagcaccct cgcattccgg gtggcccagc tggttattga ctctgacttg gacgtccttc      840

tcttcccgga taagaagcag aggaccttcc agccacccgc gacaggccac aagcgttcca      900

cgagcgaagg cgcctggcca cagctgccct ctggcctctc catgatgagg tgcctccaca      960

acttcctgac agatggggtc cctgcggagg gggcgttcac tgaagacttc cagggcctac     1020

gggcagaggt ggagaccatc tccaaggaac tggagctttt ggacagagag ctgtgccagc     1080

tgctgctgga gggcctggag ggggtgctgc gggaccagct ggccctgcga gccttggagg     1140

aggcgctgga gcagggccag agccttgggc cggtggagcc cctggacggt ccagcaggtg     1200

ctgtcctgga gtgcctggtg ttgtcctccg gaatgctggt gccggaactc gctatccctg     1260

ttgtctacct gctgggggca ctgaccatgc tgagtgaaac gcagcacaag ctgctggcgg     1320

aggcgctgga gtcgcagacc ctgttggggc cgctcgagct ggtgggcagc ctcttggagc     1380

agagtgcccc gtggcaggag cgcagcacca tgtccctgcc ccccgggctc ctggggaaca     1440

gctggggcga aggagcaccg gcctgggtct tgctggacga gtgtggccta gagctggggg     1500

aggacactcc ccacgtgtgc tgggagccgc aggcccaggg ccgcatgtgt gcactctacg     1560

cctccctggc actgctatca ggactgagcc aggagcccca ctagcctgtg cccgggcatg     1620

gcctggcagc tctccagcag ggcagagtgt ttgcccacca gctgctagcc ctaggaaggc     1680

caggagccca gtagccatgt ggccagtcta ccatggggcc caggagttgg ggaaacacaa     1740

taaaggtggc atacgaagga aaaaaaaaaa aa                                   1772


<210> 7
<211> 484
<212> PRT
<213> Homo sapiens

<400> 7
Met Gly Ser Ala Phe Glu Arg Val Val Arg Arg Val Val Gln Glu Leu 
1               5                   10                  15      


Asp His Gly Gly Glu Phe Ile Pro Val Thr Ser Leu Gln Ser Ser Thr 
            20                  25                  30          


Gly Phe Gln Pro Tyr Cys Leu Val Val Arg Lys Pro Ser Ser Ser Trp 
        35                  40                  45              


Phe Trp Lys Pro Arg Tyr Lys Cys Val Asn Leu Ser Ile Lys Asp Ile 
    50                  55                  60                  


Leu Glu Pro Asp Ala Ala Glu Pro Asp Val Gln Arg Gly Arg Ser Phe 
65                  70                  75                  80  


His Phe Tyr Asp Ala Met Asp Gly Gln Ile Gln Gly Ser Val Glu Leu 
                85                  90                  95      


Ala Ala Pro Gly Gln Ala Lys Ile Ala Gly Gly Ala Ala Val Ser Asp 
            100                 105                 110         


Ser Ser Ser Thr Ser Met Asn Val Tyr Ser Leu Ser Val Asp Pro Asn 
        115                 120                 125             


Thr Trp Gln Thr Leu Leu His Glu Arg His Leu Arg Gln Pro Glu His 
    130                 135                 140                 


Lys Val Leu Gln Gln Leu Arg Ser Arg Gly Asp Asn Val Tyr Val Val 
145                 150                 155                 160 


Thr Glu Val Leu Gln Thr Gln Lys Glu Val Glu Val Thr Arg Thr His 
                165                 170                 175     


Lys Arg Glu Gly Ser Gly Arg Phe Ser Leu Pro Gly Ala Thr Cys Leu 
            180                 185                 190         


Gln Gly Glu Gly Gln Gly His Leu Ser Gln Lys Lys Thr Val Thr Ile 
        195                 200                 205             


Pro Ser Gly Ser Thr Leu Ala Phe Arg Val Ala Gln Leu Val Ile Asp 
    210                 215                 220                 


Ser Asp Leu Asp Val Leu Leu Phe Pro Asp Lys Lys Gln Arg Thr Phe 
225                 230                 235                 240 


Gln Pro Pro Ala Thr Gly His Lys Arg Ser Thr Ser Glu Gly Ala Trp 
                245                 250                 255     


Pro Gln Leu Pro Ser Gly Leu Ser Met Met Arg Cys Leu His Asn Phe 
            260                 265                 270         


Leu Thr Asp Gly Val Pro Ala Glu Gly Ala Phe Thr Glu Asp Phe Gln 
        275                 280                 285             


Gly Leu Arg Ala Glu Val Glu Thr Ile Ser Lys Glu Leu Glu Leu Leu 
    290                 295                 300                 


Asp Arg Glu Leu Cys Gln Leu Leu Leu Glu Gly Leu Glu Gly Val Leu 
305                 310                 315                 320 


Arg Asp Gln Leu Ala Leu Arg Ala Leu Glu Glu Ala Leu Glu Gln Gly 
                325                 330                 335     


Gln Ser Leu Gly Pro Val Glu Pro Leu Asp Gly Pro Ala Gly Ala Val 
            340                 345                 350         


Leu Glu Cys Leu Val Leu Ser Ser Gly Met Leu Val Pro Glu Leu Ala 
        355                 360                 365             


Ile Pro Val Val Tyr Leu Leu Gly Ala Leu Thr Met Leu Ser Glu Thr 
    370                 375                 380                 


Gln His Lys Leu Leu Ala Glu Ala Leu Glu Ser Gln Thr Leu Leu Gly 
385                 390                 395                 400 


Pro Leu Glu Leu Val Gly Ser Leu Leu Glu Gln Ser Ala Pro Trp Gln 
                405                 410                 415     


Glu Arg Ser Thr Met Ser Leu Pro Pro Gly Leu Leu Gly Asn Ser Trp 
            420                 425                 430         


Gly Glu Gly Ala Pro Ala Trp Val Leu Leu Asp Glu Cys Gly Leu Glu 
        435                 440                 445             


Leu Gly Glu Asp Thr Pro His Val Cys Trp Glu Pro Gln Ala Gln Gly 
    450                 455                 460                 


Arg Met Cys Ala Leu Tyr Ala Ser Leu Ala Leu Leu Ser Gly Leu Ser 
465                 470                 475                 480 


Gln Glu Pro His 
                


<210> 8
<211> 736
<212> DNA
<213> Rattus norvegicus

<400> 8
acgagcattc tcgaactctc caaatagcca ccaagcagga caataggcag tcttgatcat       60

ttaaactgct gcatggcaaa aggaatcgaa ggatttctta acagaagtgg ggggggggga      120

gatctgggct tcttcctgga agtttcctga tagagaaaat cttctgcctg ggtagaatct      180

cccaggatgc agggagatgg aaaaagttgt tccccagagg actttgtagt ctacagtgtt      240

gtcgtagcca tcggaacaac gagacaccct taatttggga gtgctctgaa agaaacttgc      300

ctctaggccc tagggctctc aggcaaggag gctaagaagg aatcctttgc tgtagccttt      360

tggatttagg tttctcagct tatctatccc tcagagaagt gtgtctatgt cccttttctg      420

tccctctgcc tcaccccacc ccaacattcc aacctagggt agggggaggt cagtatacac      480

aaagccctct gtgtaagggg tggtatgtgt ccccccaccc ccctacccag agtatacaat      540

gcccctttct gctccatgcc cctgccaccc tccccaccaa cctctcaatt gcacatgcca      600

ggctgcaatt ggtccactgg ctcaggacag ccccctcatg ctggggatcc aggggatttt      660

taagcaggtt ccagaaaaca ccactcagtt ccttgtcccc ccgctctctc caccccacag      720

acgctctgcc aagctt                                                      736


<210> 9
<211> 1350
<212> DNA
<213> Rattus norvegicus

<400> 9
aagcttaact ctggttatgt agacattcca aacatctccc tttgtttgtt gagatggtct       60

ctgatagccc aggctagctt tgaactcctg accttcctgc ttcctgcttc cacctcccaa      120

gcactagaaa gagaggcata aaccacagtt gactttctag ttcttcccca caattcttca      180

ggagatgctt acagcacacg agattaactt caccctcttc agtcatctaa gaccttcaca      240

cttcctgttc agacttcttt cctagtgaac cctttcaaga gccacaccaa atcaaacatg      300

gatggcacaa acatggatgc tctaaatcta cacagagctt cacaaatgtc acacgtgcac      360

acactttcac ctcagctctt acctttgctg ttccatctag ccattgcccc tcccgttccc      420

tttttcaaaa tggctgctcc ttcaaggtct ctagacaaca ctgcttccta gacctgattc      480

ctctttcctc tgaacttcct gtattaagtg gcattcccac cgttctgtgc attggcagtt      540

gatgagtttc cctctgtttc tcccctctgc ctcctccaac tagatcttga gcttgtagaa      600

agaacggaat taccattcta atatgagcat tcgcattccc caatgtttca aatagccacc      660

aggcaggcca atacgcagtc ttgatcattt aaactgctgc attgcataag gtaccctaac      720

agacgggaga aatttgggct tcttcctgga agtttcctgg tagagaaaat cttctatctg      780

ggtagaatct cccagataca gggaggtgga aaaagttgtt ccaaagggct ttatagtcta      840

cagtgttgcc ttagcaatca gaacaacaga caccctaatt tgggagtgct ctgaaagaaa      900

cttgcctcta ggtcctaggg ctctcaggca aggagaccaa gaaggattcc tttgccatgg      960

ccttttggat ttaggtttct cagcttgtct attcctcaga gaagtgtgtc tatgcccctt     1020

ttctgtccct ctgcctcacc ctaccccaac attccaacct agggtagggg gaggtcagta     1080

tacacaaagc cctctgtgta aggggtggta tgtgtccccc cacccctcca cccaccgtat     1140

acaatgcccc ttctgctcca tgccccctgc caccctcccc accacctctc cattgcacat     1200

gccaggctgc aattggtcac tggctcagga cagccccctc atgctgggga tccaggggat     1260

tttaagcagg ttccagaaaa cacagctcag ttccttgtcc cccgctctct ccaccccaca     1320

gacactctgg gcctttgccc taccccagct                                      1350


<210> 10
<211> 982
<212> DNA
<213> Homo sapiens

<400> 10
gttcagttcc tggtccccca ctttctcaac cccacagatg ctccgggccc ctgcccctgc       60

cccagctatg gctcctgggg ctccctcatc cagccccagc cctatcctgg ctgtgctgct      120

cttctcttct ttggtgctgt ccccggccca ggccatcgtg gtttacaccg acagggaggt      180

ccatggtgct gtgggctccc gggtgaccct gcactgctcc ttctggtcca gtgagtgggt      240

ctcagatgac atctccttca cctggcgcta ccagcccgaa gggggcagag atgccatttc      300

gatcttccac tatgccaagg gacaacccta cattgacgag gtggggacct tcaaagagcg      360

catccagtgg gtaggggacc ctcgctggaa ggatggctcc attgtcatac acaacctaga      420

ctacagtgac aatggcacgt tcacttgtga cgtcaaaaac cctccagaca tagtgggcaa      480

gacctctcag gtcacgctgt atgtctttga aaaagtgcca actaggtacg gggtcgttct      540

gggagctgtg atcgggggtg tcctcggggt ggtgctgttg ctgctgctgc ttttctacgt      600

ggttcggtac tgctggctac gcaggcaggc ggccctgcag aggaggctca gtgctatgga      660

gaaggggaaa ttgcacaagc caggaaagga cgcgtcgaag cgcgggcggc agacgccagt      720

gctgtatgca atgctggacc acagcagaag caccaaagct gtcagtgaga agaaggccaa      780

ggggctgggg gagtctcgca aggataagaa atagcggtta gcgggccggg cgggggatcg      840

ggggttaggg gtggagtccg ccaaaggccc aaaggtgatg gtcatcgaga tggagctacg      900

aaaggatgag cagagcccgg agctccggcc tgctgtcaag tcccccagca gaaccagcct      960

caaaaacgcc ctcaagaaca tg                                               982


<210> 11
<211> 1103
<212> DNA
<213> Homo sapiens

<400> 11
ctgtgggcag aacaggggag agggccattg agaggccctt gtgactggag agtccaatca       60

aacgtaaagt gtgtgacagg gagggactcc tccaaattct gcaggtctct ccagactggg      120

gatccctaac acaagaggaa gtcttatgcc ccaagtgcca gaattccagg aaactcatgc      180

aatgaaacca gtcctcttgt gtcagagttt gcagctagaa gcggttcaag ggatggagga      240

ctctctggga gctggagtgg tacgctgcaa agaacctaaa tatgccataa cttcctttac      300

ttccctctcc aagaatttcc aattgctctt ccagcctatt ctgcctgaca ggttagaaag      360

ttttcaatag ttttcaatag aggttcgttt acttgcattg aattatctca tgaaggtcag      420

cttgattcgg gcacattaaa gacagagtcg gaagaacaca tttccctaag ttttattcta      480

atgtacaaca catgtgatca tttgcgatgg ggtctaggca gacaaggcag gtaacaggga      540

gtccttccaa ccaggggttg gaacaaagga ggcttgattt ggtgactctt gagacatttg      600

gctcactgct gtgatgctgt gagagattag ctgtgcaatg tttgggctcc ttaaaaggaa      660

gtttatttaa aataaaactt acctgcacgt atgtaacact gtagacacag atccttccca      720

cagtatattt aatctctgca gaattcactg ggaggggagg ggagccagtg ggacctcttg      780

gctattacac aggttggcac ttccagagag aacagtcttg gcatcacagg cttcaggcat      840

actcaaagct cttctccctt ctgattccag tttctccatg ccctgcaggg cctcttggga      900

ttattgtatt ctggaaagca aacaaagttg gacactgtct ctttaaataa tagaggctga      960

gaacctctca ggccaccatg acatatccca gcattggacc agcccctgaa taaactggaa     1020

agacgcctgg tctggcttca gttacaggga gcaccaccag ggaacatctc ggggagcctg     1080

gttggaagct gcaggcttag tct                                             1103


<210> 12
<211> 1280
<212> DNA
<213> Homo sapiens

<400> 12
gtggatggat ggatgcatga gtggatggat ggatgagtgg atagatggag gagtgggtgg       60

atgggtgaac ggatggatga gtggatgggg gatggatgga tgcatggatg gatggatggg      120

taggtgggtg tgtgtatgga tggatggata gatggatgga tgggtaaatg gactgttatg      180

tggatggatg gatgaatgga tagagagata gatggatgac tggtattaca ggaatatgtg      240

agtgaatcct gttttctgta gataagtaat agagtttgga gaggaaacta actaaatgat      300

atttatttaa acctaacact ctaacttgaa agcaaaatgg attcattgcc cttcgtgaca      360

gaaatgtggt attttttgga gaaagctatg agatgctggt atacaacatg aaatatctca      420

atcccacttc agatttctaa ttgtttctgc ttccagagga gaagccaagt caaaatgtcc      480

tgaataagca gttctctatt gtgagaggcc tcttgtggaa tctgggattg aaacaattct      540

aaatgcccca cttctttcat gcatgaattg caaaaagatg tggcaagttt tgtttctacc      600

aagaaaacta aaaacacctt ttgtcaaata aatgctcctt gcatatttaa cttatgcacc      660

agtggccttt taaacagtca atgtcccatc aaggtgcctg cacatctggg ctctccggga      720

gcagccatgg cagcacccgg gaagaaacgc tgatgtggct gctctgcatg ctcagatgac      780

ttcatcggga agcctgggtg cattttacgc tgggtgccaa atctcgagta actgaggaat      840

tcccagagcc ttctgaaaca cagagctgca ataaggctgc tccatccagg ttagctccat      900

cctaggccaa gggctttatg aggactgcac atattctgtg ggttttatag gagacagcta      960

ggtcaagacc cctcagagaa agctgctttg tccggtgctc agctttgcac aggcccgtat     1020

tcatatctca ttgttgtttg caggagaggc agatgcgaac cagaacaatg ggacctcctc     1080

tcaggacaca gcggtgactg actccaagcg cacagcggac ccgaagaatg cctggcagga     1140

tgcccaccca gctgacccag ggagccgccc ccacttgatc cgcctctttt cccgagatgc     1200

cccggggagg gaggacaaca ccttcaaaga caggccctct gagtccgacg agctccagac     1260

catccaagaa gacagtgcag                                                 1280


<210> 13
<211> 4
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Caspase 3 inhibitor peptide

<400> 13
Asp Glu Val Asp 
1               


<210> 14
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
ggggattttg gagttatggg g                                                 21


<210> 15
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 15
aaataatccc cttcccttcc c                                                 21


<210> 16
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
aagaagttta agttgaagtt gttgt                                             25


<210> 17
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
accatctcct acaaacccat atc                                               23


<210> 18
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 18
gtgatatcgc caccatgggg cgcgcgcgcg                                        30


<210> 19
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
aggatatcct agctccgctc caggtcctcc                                        30


<210> 20
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
gtcaagcttg ccaccatggg gcgcgcgc                                          28


<210> 21
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
caactagtct agctccgctc caggtcct                                          28


<210> 22
<211> 248
<212> DNA
<213> Homo sapiens

<400> 22
gatatgggtt tgtaggagat ggtcgggtag ttgtaggcgg ttacgtatta gggtgagtcg       60

ttttcgtttt tttttatttc gttttttttt tttatttata ttagcgttta tttcgcgggt      120

tttttcgttt tttgtttttt ttatttttaa ataaagttgt tttatcggaa aggaggtttt      180

ttacgtttgg tttatcgatt aacgggattt cggttttacg gcgggaaggg aagggaaggg      240

gattattt                                                               248


