
                                SEQUENCE LISTING

<110> THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
      THE SCRIPPS RESEARCH INSTITUTE
      BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
      ZALGEN LABS, LLC
      BRANCO, Luis M.
      GARRY, Robert F.
      ROBINSON, James E.
      SAPHIRE, Erica O.
      HASTIE, Kathryn M.
      GEISBERT, Thomas W.

<120> ARENAVIRUS MONOCLONAL ANTIBODIES AND
  USES

<130> TU-439-PCT

<150> US 62/430,225       
<151> 2016-12-05  

<160> 144

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 670
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 10.4B HC variable region

<221> misc_feature   
<222> 11
<223> n = A,T,C or G

<400> 1
tgcgcgttac ngatccaagc tgtgaccggc gcctacctga gatcaccggt gctagcacca 60
tggagacaga cacactcctg ctatgggtac tgctgctctg ggttccaggt tccactggtg 120
accaggtgca gctggtacag tctgggggag gcgtggtcca gcctgggagg tccctgagag 180
tctcctgtgt tacgtctgga ttcaatttca gagcctacgg catgcactgg gtccgccaga 240
ttccaggcaa gggactggag tgggtggcag atatttggtc tgccgagact aatagacact 300
atgcagattc cgtgaagggc cgattcacca tctccagaga caactccaag agcacactgt 360
atctgcaaat gaacagcctg agagccgagg acacgggcgt atatttctgt gccaaagcgc 420
gaccaggcta tgattatgtc gttgacttat ggggccaggg aacgctggtc atcgtctcct 480
cagcttccac caagggccca tcggtcttcc ccctggcgcc ctgctccagg agcacctctg 540
ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg gtgacggtgt 600
cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc ctacagtcct 660
caggactcta                                                        670

<210> 2
<211> 819
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 19.7E HC variable region

<400> 2
atccagctgt gaccggcgcc tacctgagat caccggtgct agcaccatgg agacagacac 60
actcctgcta tgggtactgc tgctctgggt tccaggttcc actggtgacg aggtgcagct 120
ggtggagtct gggggaggct tagttcggcc tggggggtcc ctgagactct cctgtgcagc 180
ctctggattc tccttcagta gctactcgat gcactgggtc cgccatgttc ctgggaaggg 240
gctggtgtgg gtctcatata ttaatagtga tgggagtact aaaatctacg cggactccgt 300
gaagggccga ttctccatct ccagagacaa tgccaagaac aagctctatc tgcaaatgga 360
cagtttgaga gtcgaggaca cggctgtata ttcgtgtgta aggcttgtac attacgactg 420
gtccccattc gtgtggggcc agggaaccct ggtcaccgtc tcctcagcct ccaccaaggg 480
cccatcggtc ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct 540
gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc 600
cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct 660
cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt 720
gaatcacaag cccagcaaca ccaaggtgga caagaaagtt gagccccaat cttgtgacaa 780
aactcacaca tgcccaccgt gcccagcacc tgaactcct                        819

<210> 3
<211> 920
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 2.9D HC variable region

<400> 3
gtcactgcac ctcggttcta tcgattggct agcaccatgg agacagacac actcctgcta 60
tgggtactgc tgctctgggt tccaggttcc actggtgacg aggtgcagct ggtggagtct 120
gggggaggcc tggtcaagcc tggggggtcc cttagactct cctgtgcagc ctctggattc 180
accttcacta gatttacttt gacctgggtc cgccaggctc cagggaaggg gctggagtgg 240
gtctcatcca ttagtagtgg gagtagtgac ataaactacg cagactcagt gaagggccga 300
ttcaccatat ccagagacaa cgccaggaac tccctgttcc tgcaaatgag cagcctgaga 360
gtcgacgaca cggctgtgta ttactgtgcg aaagatcccc ggtcggggat ctctggtcgc 420
tacgggatgg acgtctgggg ccaagggacc acggtcatcg tctcctcagc ttccaccaag 480
ggcccatcgg tcttccccct ggcgccctgc tccaggagca cctctggggg cacagcggcc 540
ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc 600
gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc 660
ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac 720
gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac 780
aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc 840
ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc 900
gtggtggtgg acgtgagcca                                             920

<210> 4
<211> 540
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 25.6A HC variable region

<400> 4
acctcggttc ttcgattggc tagcaccatg gagacagaca cactcctgct atgggtactg 60
ctgctctggg ttccaggttc cactggtgac caggtgcagc tgcaggagtc aggaggaggc 120
ctggtcaagg ctggggggtc cctgagactc tcctgtgcag cctctggatt catgttcgag 180
agatatagcc ttcactgggt ccgtcagact ccaggcaagg ggctggagtg ggtctcatcc 240
attagtagtc ttagtggcag tcacataaac tacgcagact cagtgaaggg ccgattcacc 300
atctccagag acaacgccaa gaattcactg tctctgcaaa tgaacagcct gagagtcgaa 360
gacacggcta tatattattg tgcgagagat cgacgttcgg ggagttcccc cgtccccttg 420
gacgtctggg gccaagggac cacggtcacc gtctcctctg cctccaccaa gggcccatcg 480
gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc 540


<210> 5
<211> 855
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 36.1F HC variable region

<400> 5
gtcactgccc tcggttctat cgattggcta gcaccatgga gacagacaca ctcctgctat 60
gggtactgct gctctgggtt ccaggttcca ctggtgacca ggtgcagctg caggagtcgg 120
gcgcgggact ggtgaagcct tcggagaccc tgtccctcac ctgcgctgtc tcaggtggac 180
ccttcagcgg tgcctactgg acgtggatcc gccaaactcc agggaagggg ctggagtgga 240
ttggagaggc cggtcggagt ggaaccacca actacaatcc gtccctcaag agtcgagtca 300
ccatatcact ggacacgtcc aagagccagt tttccctgaa gctgacttcc gtgaccgccg 360
cggacacggc tgtttacttc tgtgggagac gccaaataat gtctttgagt aatctttata 420
agagacccgt tgactcttgg ggccggggaa ccccggtcat cgtctcctca gcctccacca 480
agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg ggcacagcgg 540
ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg tggaactcag 600
gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca ggactctact 660
ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc tacatctgca 720
acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc aaatcttgtg 780
acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga ccgtcagtct 840
tcctcttccc cccaa                                                  855

<210> 6
<211> 874
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 36.9F HC variable region

<400> 6
gtcactgccc tcggttctat cgattggcta gcaccatgga gacagacaca ctcctgctat 60
gggtactgct gctctgggtt ccaggttcca ctggtgacga ggtgcagctg gtgcagtctg 120
gaggaggcct ggtcaaggcg ggggggtccc tgaaactctc ctgtggagcc tctggattca 180
ccttcagtag ttatagcatg agctgggtcc gccaggctcc agggaagggg ctggagtggg 240
tctcatacat tagtagtggt gggagttcta tacactacgc agactcagtg aagggccgat 300
tcaccatctc cagagacaac gccaagaatt cactgtatct gcaaatgaag aacctgaggg 360
tcgacgacac gggtcggtat tattgtgtga gagatccccg atcggggatc tctggtcggt 420
acggtatgga cgtctggggt caagggacca cggtcaccgt ctcctcagcc tccaccaagg 480
gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc acagcggccc 540
tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg aactcaggcg 600
ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga ctctactccc 660
tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac atctgcaacg 720
tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa tcttgtgaca 780
aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg tcagtcttcc 840
tcttcccccc aaacccaagg acaccctcat gatc                             874

<210> 7
<211> 859
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 37.2D HC variable region

<400> 7
tcactgccct cggttctatc gattggctag caccatggag acagacacac tcctgctatg 60
ggtactgctg ctctgggttc caggttccac tggtgacgaa gtgcagctgg tgcagtctgg 120
agctgaggtg aagaagcctg gggcttcagt gaaggtgtcc tgcaaggcct ctggttacac 180
ctttacgaaa tacggaatca gctgggtgcg acaggcccct ggacaagggc ttgagtggat 240
gggatggatc agcgcgttta atggttacac aaggtatggt cagagattcc agggcaaagt 300
caccatgacc acagacacat ccacgaacac agcctctttg gaggtgagga ccctgacatc 360
taacgacacg gccgtctatt actgtgcgag acaatatccc gaccaatata gtagcagcgg 420
ttggccccgc ctcttcgcca tggacgtctg gggccaaggg accacggtca tcgtctcccc 480
agcctccacc aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg 540
gggcacagcg gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc 600
gtggaactca ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc 660
aggactctac tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac 720
ctacatctgc aacgtgaatc acaagcccag caacaccaag gtggacaaga gagttgagcc 780
caaatcttgt gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg 840
accgtcagtc ttcctcttc                                              859

<210> 8
<211> 960
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 37.2G HC variable region

<400> 8
tcactgccct cggttctatc gattggctag caccatggag acagacacac tcctgctatg 60
ggtactgctg ctctgggttc caggttccac tggtgacgag gtgcagctgg tggagtctgg 120
gggaggcctg gtcaagccgg gggggtcccg gagactctcc tgtgctgcct ctggattcac 180
cttcagtaga gataccatga cctgggtccg ccaggctcca gggaaggggc tggagtgggt 240
cgcatccata agtagtggta gcagtgacat aaactacgca gactcagtga agggccgatt 300
caccatctcc agagacaacg gcaagaactc actgtatctg cacatgaaca gcctgagagc 360
cgacgacacg gctatatatt actgtgcgag agatccccgg tcgggaatct ctggtcggta 420
tggtatggac gtctggggcc aagggaccac ggtcaccgtc tcctcagcct ccaccaaggg 480
cccatcggtc ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct 540
gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc 600
cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct 660
cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt 720
gaatcacaag cccagcaaca ccaaggtgga caagagagtt gagcccaaat cttgtgacaa 780
aactcacaca tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct 840
cttcccccca aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt 900
ggtggtggac gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt 960


<210> 9
<211> 924
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 37.7H HC variable region

<400> 9
gtcactgcac ctcggttcta tcgattggct agcaccatgg agacagacac actcctgcta 60
tgggtactgc tgctctgggt tccaggttcc actggtgacg aggtgcagct ggtgcagtct 120
ggaggaggcc tggtcaaggc gggggggtcc ctgaggctct cctgtgcagc ctccggattc 180
acattcagca cctacagtat gaactggatc cgccaggctc cagggaaggg gctggagtgg 240
gtcgcttcca ttagtagtcg aagtggcagt cacataaact acgtagactc agtgaaggga 300
cgattcacca tctccagaga caacgccagg gacttattgt atctgcaaat gaacagcctg 360
agagtcgacg actcggctct ctattactgt gcgagagatc gccgttcggg gacttctccc 420
ctccccttgg acgtctgggg ccaagggacc acggtcaccg tcttctcagc ctccaccaag 480
ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc 540
ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc 600
gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc 660
ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac 720
gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac 780
aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc 840
ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc 900
gtggtggtgg acgtgagcca cgaa                                        924

<210> 10
<211> 911
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 8.9F HC variable region

<400> 10
cctcggttct atcgattggc tagcaccatg gagacagaca cactcctgct atgggtactg 60
ctgctctggg ttccaggttc cactggtgac cagggcacct tgagggagtc tggtccagga 120
ctggtgaggc cttcggagac cctgtccctc acctgcggtg tctctggtta ttccatcagt 180
agtggttact actggggctg gatccggcag cccccaggga aggggctgga gtggattggg 240
aatatctatc gtagtgggag cacctactac aacccgtccc tcaagagtcg agtcaccgtc 300
tcaatagaca cgtccaaaaa ccagttctcc ctgaagttga attctgtgac cgccgcagac 360
acggccgtgt attactgtgc gagatcgggt ataaaagtgg ctgacgacta ttactacgaa 420
atggacgtct ggggccaagg gaccgacgac tactcttacg ctatggacgt ctggggccaa 480
gggaccacgg tcaccgtctc ctcagcctcc accaagggcc catcggtctt ccccctggca 540
ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac 600
ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc 660
ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc 720
tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc 780
aaggtggaca agagagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc 840
ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac 900
accctcatga t                                                      911

<210> 11
<211> 881
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA NE13 HC variable region

<400> 11
actgcacctc ggttctatcg attggctagc accatggaga cagacacact cctgctatgg 60
gtactgctgc tctgggttcc aggttccact ggtgacgagg ttcagctggt ggagtctggg 120
ggaggcctgg tcaagcctgg ggggtccctg agactctcct gtgtagcctc tggattcacc 180
ttcagttcct atagcatgaa ctgggtccgc caggctccag ggaaggggct ggagtgggtc 240
tcatccatta gtagtggtag tagttacata gagtacgcag actcagtgaa gggccgactc 300
accatctcca gagacaacgc caagaagtca ctgtatctgc aactgaacag cctgagagcc 360
gaggacacgg ctgtgtatta ctgtgcgaga cacacagctc gaatcgactc ttaccacggt 420
atggacgtct ggggccaagg gaccacagtc accgtctcct cagcctccac caagggccca 480
tcggtcttcc ccctggcacc ctcctccaag agcacctctg ggggcacagc ggccctgggc 540
tgcctggtca aggactactt ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg 600
accagcggcg tgcacacctt cccggctgtc ctacagtcct caggactcta ctccctcagc 660
agcgtggtga ccgtgccctc cagcagcttg ggcacccaga cctacatctg caacgtgaat 720
cacaagccca gcaacaccaa ggtggacaag agagttgagc ccaaatcttg tgacaaaact 780
cacacatgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc 840
cccccaaaac ccaaggacac cctcatgatc tcccggaccc c                     881

<210> 12
<211> 921
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 12.1F HC variable region

<221> misc_feature   
<222> 849
<223> n = A,T,C or G

<400> 12
gtcactgcac ctcggttcta tcgattggct agcaccatgg agacagacac actcctgcta 60
tgggtactgc tgctctgggt tccaggttcc actggtgacc aggtgcagct gcaggagtcg 120
ggcgcaggac tgttgaagcc ttcggagacc ctgtccctca gttgcactgt cgatggtgag 180
tccttcaatg gtttcttctg gacgtggatc cgccagcccc cagggaaggg tctggagtgg 240
attggagaaa tcaatcatct tgcaagcacc ggctacaacc cgtccctcaa gagtcgagtc 300
accatttcag tagacacgtc caagaaccag ttctctttga agttgacctc tgtgaccgcc 360
gcggacacgg ctgtgtatta ctgtgcgaga ggatacagct atggttttgc atggcccaac 420
taccactatt tggacgtctg gggcaaaggg accacggtca ccgtctcctc agcctccacc 480
aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg 540
gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca 600
ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac 660
tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc 720
aacgtgaatc acaagcccag caacaccaag gtggacaaga gagttgagcc caaatcttgt 780
gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc 840
ttcctcttnc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 900
tgcgtggtgg tggacgtgag c                                           921

<210> 13
<211> 874
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 9.8A HC variable region

<400> 13
ttctatcgat ttggctagca ccatggagac agacacactc ctgctatggg tactgctgct 60
ctgggttcca ggttccactg gtgacgaggt gcagctggtg cagtctggag gacgcttggt 120
acagcctggg gggtccctga gactctcctg tgtagcctct ggattcacct ttagcagcca 180
tgccatgagc tgggtccgcc aggctccagg gaaggggctg gagtgggtct caggttttag 240
tggtagtagt ggtaccacaa agtacgcaga ctccgtgaag ggccggttca ccatctccag 300
agacaattcc aagaaaacgc tgtatctgca aatgaacagc ctgagagccg aggacacggc 360
cgtatattac tgtgcgaaag gcttctcccc atttcgggga gtacaattcc cctactttga 420
ctactggggc cagggaacgc tggtcaccgt ctcctcagcc tccaccaagg gcccatcggt 480
cttccccctg gcaccctcct ccaagagcac ctctgggggc acagcggccc tgggctgcct 540
ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg aactcaggcg ccctgaccag 600
cggcgtgcac accttcccgg ctgtcctaca gtcctcagga ctctactccc tcagcagcgt 660
ggtgaccgtg ccctccagca gcttgggcac ccagacctac atctgcaacg tgaatcacaa 720
gcccagcaac accaaggtgg acaagagagt tgagcccaaa tcttgtgaca aaactcacac 780
atgcccaccg tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc 840
aaaacccagg acaccctcat gatctcccgg accc                             874

<210> 14
<211> 898
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 18.5C HC variable region

<400> 14
gtccactgca cctcggttct atcgattggc tagcaccatg gagacagaca cactcctgct 60
atgggtactg ctgctctggg ttccaggttc cactggtgac gaggttcagc tggtggagtc 120
tgggggaggc ctggtcaggc cgggggggtc ccttagactc tcctgtgcag ccgctggatt 180
cactttcaag agttatagca tgaattgggt ccgccaggct ccagggaggg gcctggagtg 240
ggtctcatct atcactagtg gtggtagtaa gacatactat gcagacgtag tgaagggccg 300
attcaccgtc tccagagaca acgccaagca gtcgctctat ctgcaaatga acagcctgag 360
agccgaggac acggctatat acttctgtgc gagatcccta catagtacca gccagcctag 420
ctacatggac gtctggggca gaaagatcac ggtcatcgtc tcctcagcct ccaccaaggg 480
cccatcggtc ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct 540
gggctgcctg gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc 600
cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct 660
cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt 720
gaatcacaag cccagcaaca ccaaggtgga caagagagtt gagcccaaat cttgtgacaa 780
aactcacaca tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct 840
cttcccccca aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgc   898

<210> 15
<211> 903
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 8.11G HC variable region

<400> 15
tgcacctcgg ttctatcgat tggctagcac catggagaca gacacactcc tgctatgggt 60
actgctgctc tgggttccag gttccactgg tgaccaggtg cagctgcagg agtcgggtcc 120
aggactggtg aagccttcgg agaccctgtc cctcacctgc agtatttctg gtgtgtccac 180
cagaaattat tattggagct ggatccgcca gtccccaggg aagggactgg agtggattgg 240
atatatcttt aacattggga ccaccaacta caatccgtcc ctcaagagtc gactcaccat 300
atctgtagac acgtcgaaga accagttctc cctgaagatc acctctgtga ccgctgcgga 360
cacggccgtc tattactgtg cgagtggatt tgagtacggt gactatacct tcgactactg 420
gggccaggga accccggtca ccgtctcctc agcctccacc aagggcccat cggtcttccc 480
cctggcaccc tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa 540
ggactacttc cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt 600
gcacaccttc ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac 660
cgtgccctcc agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag 720
caacaccaag gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc 780
accgtgccca gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc 840
caaggacacc ctcatgatct tccggacccc tgaggtcaca tgcgtggtgg tggacgtgag 900
cca                                                               903

<210> 16
<211> 860
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 25.10C HC variable region

<400> 16
ctcggttcta tcgattggct agcaccatgg agacagacac actcctgcta tgggtactgc 60
tgctctgggt tccaggttcc actggtgacc aggtgcagct gcaggagtct gggggaggcc 120
tggtcaagcc tggggggtcc ctgagactct cctgtacagc ctctggattc aacttcaata 180
aatataacat gaactgggtc cgccaggctc cagggaaggg gctggagtgg gtctcatcca 240
ttagtgctct tagcacttac atctattatg cagactcgct gaagggccga ttcaccgtct 300
ccagagacaa cgccaagaac tcactgtttc tgcaaatgaa cagcctgaga gacgacgaca 360
cggctgttta ttactgtgcg agagaaatac gacgtgccag tacctggtcc gccgacctct 420
ggggccgtgg cactctggtc actgtctcct cagcctccac caagggccca tcggtcttcc 480
ccctggcacc ctcctccaag agcacctctg ggggcacagc ggccctgggc tgcctggtca 540
aggactactt ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg accagcggcg 600
tgcacacctt cccggctgtc ctacagtcct caggactcta ctccctcagc agcgtggtga 660
ccgtgccctc cagcagcttg ggcacccaga cctacatctg caacgtgaat cacaagccca 720
gcaacaccaa ggtggacaag agagttgagc ccaaatcttg tgacaaaact cacacatgcc 780
caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc cctccaaacc 840
caaggacacc ctcatgatct                                             860

<210> 17
<211> 716
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 10.4B LC variable region

<400> 17
agctgtgacc ggcgcctacc tgagatcacc ggtgctagca ccatggagac agacacactc 60
ctgctatggg tactgctgct ctgggttcca ggttccactg gtgacgaaat tgtgttgaca 120
cagtctccat cctcactgtc tgcgtctgta ggagacagag tcaccatcac ttgtcgggcg 180
agtcgggaca tcaatactta tttaggttgg tttcagcaga gaccagggaa agcccctaag 240
tccctgatct atggtgcatc taatttgcaa aatggggtcc catcaaggtt cagcggcagt 300
ggatctggga cgtattttac tctcaccatc aacggcctgc agactgaaga ctttgcgact 360
tattattgcc aacaatatag catctacccg ctcagtctcg gcggagggac caaggcggac 420
atgaagcgaa ctgtggctgc accatctgtc ttcatcttcc cgccatctga tgagcagttg 480
aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag agaggccaaa 540
gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag tgtcacagag 600
caggacagca aggacagcac ctacagcctc agcagcaccc tgacgctgag caaagcagac 660
tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc agggcctgag ctcgcc     716

<210> 18
<211> 906
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 19.7E LC variable region

<400> 18
tcagctgtga ccggcgccta cctgagatca ccggtgctag caccatggag acagacacac 60
tcctgctatg gctcctgctg ctctgggttc caggttccac tggtgacgaa attgtgttga 120
cacagtctcc ttccaccctg tctgcatctg tgggagacag agtcaccatc acttgccggg 180
ccagtcagag tattaataat tggttggcct ggtatcagga gaaaccaggg aaagccccta 240
agctcctgat aaataaggcg tctagtttag aaagtggggt cccatcaagg ttcagcggca 300
gtggatctgg gacagaattc actctcacca tcaccagcct gcagcctgat gattttgcaa 360
cttattactg ccaacaatat aatagtaatt cgtggacgtt cggccaaggg accaaggtgg 420
acatgaaacg aactgtggct gcaccatctg tcttcatctt cccgccatct gatgagcagt 480
tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc agagaggcca 540
aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag agtgtcacag 600
agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg agcaaagcag 660
actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg agctcgcccg 720
tcacaaagag cttcaacagg ggagagtgtt agagggagct agctcgacat gataagatac 780
attgatgagt ttgggacaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa 840
atttgtgatg ctattgcttt tattgtgaaa tttgtgatgc tattgcttta tttgtaacca 900
ttataa                                                            906

<210> 19
<211> 894
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 2.9D LC variable region

<400> 19
actgcacctc ggttctatcg attggctagc accatgaaga cagacacact cctgctatgg 60
gtactgctgc tctgggttcc aggttccact ggtgacgaca ttgtgctgac ccagtctcca 120
gactccctgg ctgtgtctct gggcgagagg gccaccatca actgcaagtc cagccagagt 180
gttttataca gctccaacaa taagaactac ttagcttggt accagcagaa gccaggacag 240
cctcctaagc tgctcattta ctgggcatct acccgggaat ccggggtccc tgaccgattc 300
agtggcagcg ggtctgggac agatttcact ctcaccatca gcagcctgca ggctgaagat 360
gtggcagttt attactgtca gcaatattat agtactcctc cgacgttcgg ccaagggacc 420
aaggtggaaa tcaaacgaac tgtggctgca ccatctgtct tcatcttccc gccatctgat 480
gagcagttga aatctggaac tgcctctgtt gtgtgcctgc tgaataactt ctatcccaga 540
gaggccaaag tacagtggaa ggtggataac gccctccaat cgggtaactc ccaggagagt 600
gtcacagagc aggacagcaa ggacagcacc tacagcctca gcagcaccct gacgctgagc 660
aaagcagact acgagaaaca caaagtctac gcctgcgaag tcacccatca gggcctgagc 720
tcgcccgtca caaagagctt caacagggga gagtgttagg cggccgcaag cttggccgcc 780
atggcccaac ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa 840
tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca actc       894

<210> 20
<211> 903
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 25.6A LC variable region

<400> 20
ctcggttcta tcgattggct agcaccatgg agacagacac actcctgcta tgggtactgc 60
tgctctgggt tccaggttcc actggtgacc tgcctgtgct gactcagcct gcctccgtgt 120
ctgggtctcc tggacagtcg atcaccatct cctgcactgg aaccagcagt gacgttggtg 180
cttataacta tgtctcctgg taccaacagc acccaggcaa agcccccaaa ctcataattt 240
atgaagtcaa gattcggccg tcaggggtgt ctaatcgttt ctctggctcc aagtctggca 300
acacggcctc cctgaccatc tctgggctcc aggctgagga cgaggctgat tatttttgca 360
gctcatattc aaccaacagc ccttgggtgt tcggcggagg gacgaaggtg accgtcctac 420
gtcagcccaa ggctgccccc tcggtcactc tgttcccacc ctcctctgag gagcttcaag 480
ccaacaaggc cacactggtg tgtctcataa gtgacttcta cccgggagcc gtgacagtgg 540
cctggaaggc agatagcagc cccgtcaagg cgggagtgga gaccaccaca ccctccaaac 600
aaagcaacaa caagtacgcg gccagcagct acctgagcct gacgcctgag cagtggaagt 660
cccacagaag ctacagctgc caggtcacgc atgaagggag caccgtggag aagacagtgg 720
cccctacaga atgttcatga gcggccgcaa gcttggccgc catggcccaa cttgtttatt 780
gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt 840
ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg 900
atc                                                               903

<210> 21
<211> 900
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 36.1F LC variable region

<400> 21
tccaggtcac tgcacctcgg ttctatcgat tggctagcac catggagaca gacacactcc 60
tgctatgggt actgctgctc tgggttccag gttccactgg tgacgaaatt gtgctgacac 120
agtctccagg caccctgtct ttgtctccag gggaaagagc caccctctcc tgcagggcca 180
gtcagagtgt tactaaaaac tacttagcct ggtaccagca gaaacctggc caggctccca 240
ccctcgtcat ctatgatgca tccaccaggg ccagtggcat cccagacagg ttcattggca 300
gtgggtctgg gacagacttc actctcacca tcagcagact ggagcctgaa gattttgcag 360
tatattactg ccaccagtat ggcagctcac ctccgtacac ttttggccgg gggaccaagc 420
tggagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca tctgatgagc 480
agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat cccagagagg 540
ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag gagagtgtca 600
cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg ctgagcaaag 660
cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc ctgagctcgc 720
ccgtcacaaa gagcttcaac aggggagagt gttaggcggc cgcaagcttg gccgccatgg 780
cccaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc 840
acaaataaag catttttttc actgcattct agttgtgggt tgtccaaact catcaatgta 900


<210> 22
<211> 922
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 36.9F LC variable region

<400> 22
aggtcactgc acctcggttc tatcgattgg ctagcaccat ggagacagac acactcctgc 60
tatgggtact gctgctctgg gttccaggtt ccactggtga cgacatcgtg atgacccagt 120
ctccagactc cctggctgtg tctctgggcg agagggccac catcaactgc aagtccagcc 180
agactgtttt gttcacctcc tattacgtag cttggtatca acaaaagcca gggcagccgc 240
ctaagttgct cttttccggg gcctcttctc gggaatccgg ggtccctgac cgattcagtg 300
ccggcgggtc tgggacagat ttctatctca ccatcaacag cctgcaggct gaagatgtgg 360
cagattacta ttgtcagcaa tatcatactc ctcctttcac tttcggcgga gggaccaagc 420
tggagatcag acgaactgtg gctgcaccat ctgtcttcat cttcccgcca tctgatgagc 480
agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat cccagagagg 540
ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag gagagtgtca 600
cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg ctgagcaaag 660
cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc ctgagctcgc 720
ccgtcacaaa gagcttcaac aggggagagt gttaggcggc cgcaagcttg gccgccatgg 780
cccaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc 840
acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta 900
tcttatcatg tctggatcgg ga                                          922

<210> 23
<211> 858
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 37.2D LC variable region

<400> 23
tcactgcacc tcggttctat cgattggcta gcaccatgga gacagacaca ctcctgctat 60
gggtactgct gctctgggtt ccaggttcca ctggtgacga aacgacactc acgcagtctc 120
cagccaccct gtctgtgtct ccaggggaaa cagccaccct ctcctgcagg gccagtcaaa 180
atgttatcaa caacttagcc tggtaccagc agaaacctgg ccaggctccc aggctcctca 240
tttatggtgc atccaccagg gccactggta tcccagccag gttcagtggc agtgggtctg 300
ggacagagtt cactctcacc atcagcagca tgcagtctga agattttgca gtttattact 360
gtcagcaata taatgactgg cctcgaagtt ttggccaggg gaccaggctg gacatcagac 420
gaactgtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag ttgaaatctg 480
gaactgcctc tgttgtgtgc ctgctgaata acttctatcc cagagaggcc aaagtacagt 540
ggaaggtgga taacgccctc caatcgggta actcccagga gagtgtcaca gagcaggaca 600
gcaaggacag cacctacagc ctcagcagca ccctgacgct gagcaaagca gactacgaga 660
aacacaaagt ctacgcctgc gaagtcaccc atcagggcct gagctcgccc gtcacaaaga 720
gcttcaacag gggagagtgt taggcggccg caagcttggc cgccatggcc caacttgttt 780
attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca 840
tttttttcac tgcattct                                               858

<210> 24
<211> 958
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 37.7G LC variable region

<400> 24
tccaggtcac tgccctcggt tctatcgatt ggctagcacc atggagacag acacactcct 60
gctatgggta ctgctgctct gggttccagg ttccactggt gacgacattg tgctgaccca 120
gtctccaggc accctgtctt tgtctccagg ggaaagagcc accctctcct gcagggccag 180
tcagagtgtg aacagcatct tcttagcctg gtaccagcag aaacctggcc aggctcccag 240
gctcctcatc tatggtgcat ccagcagggc cactggcatc ccagacaggt tcagtggcag 300
tgggtctggg acagacttca ctctcaccat cagcagactg gagcctgagg attttgcagt 360
gtattactgt cagcagtatc atagctcacc taagctcact ttcggcggag ggaccaaggt 420
ggagatcaaa cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctggtgagca 480
gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc 540
caaagtacag tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac 600
agagcaggac agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc 660
agactacgag aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc 720
cgtcacaaag agcttcaaca ggggagagtg ttaggcggcc gcaagcttgg ccgccatggc 780
ccaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca 840
caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat 900
cttatcatgt ctggatcggg aattaattcg gcgcagcacc atggcctgaa ataacctc   958

<210> 25
<211> 1015
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 37.7H LC variable region

<400> 25
tcactgcacc tcggttctat cgattggcta gcaccatgga gacagacaca ctcctgctat 60
gggtactgct gctctgggtt ccaggttcca ctggtgacca gtctgccctg actcagcctg 120
cctccgtgtc tgggtctcct ggacagtcga tcaccatctc ctgcactgga accggcagtg 180
acattggtgg ttataacttt gtctcctggt accaacagta tcccggcaaa gcccccaaac 240
tcattattta tgaggtccgt attcgggcct caggggtttc caatcgcttc tctggctcca 300
agtctggcaa cacggcctcc ctgaccatct ctggactcca ggctgaggac gaggctgatt 360
attactgcaa ctcatattca atccacagcc cttgggtgtt cggcggaggg accaagttga 420
ccgtcctgcg tcagcccaag gctgccccct cggtcactct gttcccaccc tcctctgagg 480
agcttcaagc caacaaggcc acactggtgt gtctcataag tgacttctac ccgggagccg 540
tgacagtggc ctggaaggca gatagcagcc ccgtcaaggc gggagtggag accaccacac 600
cctccaaaca aagcaacaac aagtacgcgg ccagcagcta cctgagcctg acgcctgagc 660
agtgggagtc ccacagaagc tacagctgcc aggtcacgca tgaagggagc accgtggaga 720
agacagtggc ccctacagaa tgttcatgag cggccgcaag cttggccgcc atggcccaac 780
ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat 840
aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat 900
catgtctgga tcgggaatta attcggcgca gcaccatggc ctgaaatacc ctctgaaaga 960
ggaacttggt taggtacctt ctgaggcgga aagaaccatc tgtggaatgt gtgtc      1015

<210> 26
<211> 910
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 8.9F LC variable region

<400> 26
cactgccctc ggttctatcg attggctagc accatggaga cagacacact cctgctatgg 60
gtactgctgc tctgggttcc aggttccact ggtgaccagg cagggctgac tcagcctgcc 120
tccgtgtctg ggtctcctgg acagtcgatc accatctcct gcactgcagc caacagtgac 180
attggtgatt ttaactttgt ctcctggtac caacagcgcc cagacaaagc ccccaaactc 240
atggtttatg aggtcagcag tcggccctca ggggtttcta atcgcttctc tggctccaag 300
tctggcaaca cggcctccct gaccatctct gggctccagg ctgaggacga ggctgattat 360
tactgcacct catatacaag cagcagcact tttgtcttcg gaactgggac caaggtcacc 420
gtcctaggtc agcccaaggc caaccccact gtcactctgt tcccgccctc ctctgaggag 480
cttcaagcca acaaggccac actggtgtgt ctcataagtg acttctaccc gggagccgtg 540
acagtggcct ggaaggcaga tagcagcccc gtcaaggcgg gagtggagac caccacaccc 600
tccaaacaaa gcaacaacaa gtacgcggcc agcagctacc tgagcctgac gcctgagcag 660
tggaagtccc acagaagcta cagctgccag gtcacgcatg aagggagcac cgtggagaag 720
acagtggccc ctacagaatg ttcatgagcg gccgcaagct tggccgccat ggcccaactt 780
gtttattgca gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa 840
agcatttttt tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca 900
tgtctggatc                                                        910

<210> 27
<211> 908
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA NE13 LC variable region

<400> 27
ctcccaggtc actgcacctc ggttctatcg attggctagc accatggaga cagacacact 60
cctgctatgg gtactgctgc tctgggttcc aggttccact ggtgacgaaa cgacactcac 120
gcagtctcca ggcaccctgt ctttgtctcc aggggaaaga gccaccctct cctgcagggc 180
cagtcagagt gttagcagca cctacttagc ctggtaccag cagaaacctg gccagtctcc 240
caggctcctc atttatggtg catccagtag ggccactggc atcccagaca ggttcagtgg 300
cagtgggtct gggacacagt tcactctcac catcaacaga ctggagcctg aagattttgc 360
agtgtattac tgtcagcagt ttggtagccc gtggacattc ggccaaggga ccaaggtgga 420
aatcaaacga actgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt 480
gaaatctgga actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa 540
agtacagtgg aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga 600
gcaggacagc aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga 660
ctacgagaaa cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt 720
cacaaagagc ttcaacaggg gagagtgtta ggcggccgca agcttggccg ccatggccca 780
acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa 840
ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt 900
atcatgtc                                                          908

<210> 28
<211> 932
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 12.1F LC variable region

<400> 28
gtcactgcac ctcggttcta tcgattggct agcaccatgg agacagacac actcctgcta 60
tgggtactgc tgctctgggt tccaggttcc actggtgacg aaacgacact cacgcagtct 120
ccagccaccc tgtctttgtc tccaggggag agagccaccc tctcctgtag ggccagtcag 180
agtgttagca gctacttagc ctggtaccaa cacaaacctg gccaggctcc caggctcctc 240
atctatggtg catcaaagag ggccactggc atcccgtcca ggttcagtgg cagtgggtct 300
gggacagact tcagtctcac catcagcagc ctagagcctg aagattttgc agtttactac 360
tgtcagcacc gaagcgactg gcggactacc ttcggccaag ggacacgact ggagattaaa 420
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct 480
ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag 540
tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac 600
agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag 660
aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag 720
agcttcaaca ggggagagtg ttaggcggcc gcaagcttgg ccgccatggc ccaacttgtt 780
tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc 840
atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt 900
ctggatcggg aaattaatcg gcgcagcacc at                               932

<210> 29
<211> 895
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 9.8A LC variable region

<400> 29
ggttctatcg attggctagc accatggaga cagacacact cctgctatgg gtactgctgc 60
tctgggttcc aggttccact ggtgacgaca tcgtgatgac ccagtctcct tccaccctgt 120
ctgcatctgt aggagacaga gtcaccatca cttgccgggc cagtcagagt attgataggt 180
ggttggcctg gtatcagcag aaaccaggga aagcccctaa gctcctgatc tatcaggcat 240
ctagtttaga aagaggggtc ccatcaaggt tcagcggcag tggatctggg acagaattca 300
ctctcaccat cagcagcctg cagcccgatg attttgcaac ttattactgc caacagtata 360
atggttaccc tctcactttc ggcggaggga ccaaggtgga gatcaaacga actgtggctg 420
caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga actgcctctg 480
ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg aaggtggata 540
acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc aaggacagca 600
cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct 660
acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc ttcaacaggg 720
gagagtgtta ggcggccgca agcttggccg ccatggccca acttgtttat tgcagcttat 780
aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg 840
cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatcg      895

<210> 30
<211> 784
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 18.5C LC variable region

<400> 30
tccaggtcca ctgcacctcg gttctatcga ttggctagca ccatggagac agacacactc 60
ctgctatggg tactgctgct ctgggttcca ggttccactg gtgacgacat ccagatgacc 120
cagtctccag gcaccctgtc tttgtctcca ggggaaagag ccaccctctc ctgcagggcc 180
agtcagagtg ttatcagtta ctacgtagcc tggtaccagc acaaaggtgg ccaggctccc 240
aggctcctca tttatggtgc atccagcagg gccactggcg tcccagacag gttcagtggc 300
agtgggtctg ggacagactt cactctcacc atcagcagcc tggagcctga agattttgca 360
ctgtattact gtcagtacta tgggagctca cctctgtggg cgttcggcca agggaccaag 420
gtggaaatca aacgaactgt ggctgcacca tctgtcttca tcttcccgcc atctgatgag 480
cagttgaaat ctggaactgc ctctgttgtg tgcctgctga ataacttcta tcccagagag 540
gccaaagtac agtggaaggt ggataacgcc ctccaatcgg gtaactccca ggagagtgtc 600
acagagcagg acagcaagga cagcacctac agcctcagca gcaccctgac gctgagcaaa 660
gcagactacg agaaacacaa agtctacgcc tgcgaagtca cccatcaggg cctgagctcg 720
cccgtcacaa agagcttcaa caggggagag tgttaggcgg ccgcaagctt ggccgccatg 780
gccc                                                              784

<210> 31
<211> 845
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 8.11G LC variable region

<400> 31
cggttctatc gattggctag caccatggag acagacacac tcctgctatg ggtactgctg 60
ctctgggttc caggttccac tggtgacgaa attgtgctga ctcagtctcc agccaccctg 120
tctgtgtctc cagggggtag ggcctccctc tcctgccggg ccagtcagag tattggcgac 180
aagttatcct ggtatcagca gaaacctggg caggctccca ggctcgtcat ctatggtgca 240
tataccaggg ccactgatat ctcacccagg ttcagtggca gtaggtctgg gacagacttc 300
aatctcacca tcagcagaat gcagtctgga gactttgcag tttatttctg tcagcagtat 360
gaaaactggc ctcggacttt tggccagggg accaagctgg agatcaaacg aactgtggct 420
gcaccatctg tcttcatctt cccgccatct gatgagcagt tgaaatctgg aactgcctct 480
gttgtgtgcc tgctgaataa cttctatccc agagaggcca aagtacagtg gaaggtggat 540
aacgccctcc aatcgggtaa ctcccaggag agtgtcacag agcaggacag caaggacagc 600
acctacagcc tcagcagcac cctgacgctg agcaaagcag actacgagaa acacaaagtc 660
tacgcctgcg aagtcaccca tcagggcctg agctcgcccg tcacaaagag cttcaacagg 720
ggagagtgtt aggcggccgc aagcttggcc gccatggccc aacttgttta ttgcagctta 780
taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact 840
gcatt                                                             845

<210> 32
<211> 900
<212> DNA
<213> Artificial Sequence

<220> 
<223> cDNA 25.10C LC variable region

<400> 32
cctcggttct atcgattggc tagcaccatg gagacagaca cactcctgct atgggtactg 60
ctgctctggg ttccaggttc cactggtgac gacatccaga tgacccagtc tccatcctcc 120
ctgtctgcat ctgttggaga cagagtcatc atcacttgcc gggcaagtca gagcatcagc 180
agctctttaa attggtatca gcagaaacca gggaaagccc ctaagctcct gatctatgct 240
gcagtcaatt tggagactgg ggtcccgtca aggttcagtg gcagtggatt tgggacagat 300
ttcactctcg ccatcagcaa tgtgcaacct gaagattttg caacttacta ctgtcaacag 360
agcgatactc ggacttttgg ccgggggacc aagctggacg tcaaacgaac tgtggctgca 420
ccatctgtct tcatcttccc gccatctgat gagcagttga aatctggaac tgcctctgtt 480
gtgtgcctgc tgaataactt ctatcccaga gaggccaaag tacagtggaa ggtggataac 540
gccctccaat cgggtaactc ccaggagagt gtcacagagc aggacagcaa ggacagcacc 600
tacagcctca gcagcaccct gacgctgagc aaagcagact acgagaaaca caaagtctac 660
gcctgcgaag tcacccatca gggcctgagc tcgcccgtca caaagagctt caacagggga 720
gaagtgttag gcggccgcaa gcttggccgc catggcccaa cttgtttatt gcagcttata 780
atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc 840
attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg atcgggaatt 900


<210> 33
<211> 203
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC variable region

<400> 33
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val
            20                  25                  30          
Val Gln Pro Gly Arg Ser Leu Arg Val Ser Cys Val Thr Ser Gly Phe
        35                  40                  45              
Asn Phe Arg Ala Tyr Gly Met His Trp Val Arg Gln Ile Pro Gly Lys
    50                  55                  60                  
Gly Leu Glu Trp Val Ala Asp Ile Trp Ser Ala Glu Thr Asn Arg His
65                  70                  75                  80  
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
                85                  90                  95      
Lys Ser Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
            100                 105                 110         
Gly Val Tyr Phe Cys Ala Lys Ala Arg Pro Gly Tyr Asp Tyr Val Val
        115                 120                 125             
Asp Leu Trp Gly Gln Gly Thr Leu Val Ile Val Ser Ser Ala Ser Thr
    130                 135                 140                 
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser
145                 150                 155                 160 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
                165                 170                 175     
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
            180                 185                 190         
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu
        195                 200             


<210> 34
<211> 258
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC variable region

<400> 34
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
            20                  25                  30          
Val Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
        35                  40                  45              
Ser Phe Ser Ser Tyr Ser Met His Trp Val Arg His Val Pro Gly Lys
    50                  55                  60                  
Gly Leu Val Trp Val Ser Tyr Ile Asn Ser Asp Gly Ser Thr Lys Ile
65                  70                  75                  80  
Tyr Ala Asp Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala
                85                  90                  95      
Lys Asn Lys Leu Tyr Leu Gln Met Asp Ser Leu Arg Val Glu Asp Thr
            100                 105                 110         
Ala Val Tyr Ser Cys Val Arg Leu Val His Tyr Asp Trp Ser Pro Phe
        115                 120                 125             
Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys
    130                 135                 140                 
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly
145                 150                 155                 160 
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro
                165                 170                 175     
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr
            180                 185                 190         
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
        195                 200                 205             
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn
    210                 215                 220                 
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro
225                 230                 235                 240 
Gln Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
                245                 250                 255     
Leu Leu
        


<210> 35
<211> 294
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC variable region

<400> 35
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
            20                  25                  30          
Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
        35                  40                  45              
Thr Phe Thr Arg Phe Thr Leu Thr Trp Val Arg Gln Ala Pro Gly Lys
    50                  55                  60                  
Gly Leu Glu Trp Val Ser Ser Ile Ser Ser Gly Ser Ser Asp Ile Asn
65                  70                  75                  80  
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
                85                  90                  95      
Arg Asn Ser Leu Phe Leu Gln Met Ser Ser Leu Arg Val Asp Asp Thr
            100                 105                 110         
Ala Val Tyr Tyr Cys Ala Lys Asp Pro Arg Ser Gly Ile Ser Gly Arg
        115                 120                 125             
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Ile Val Ser Ser
    130                 135                 140                 
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
145                 150                 155                 160 
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
                165                 170                 175     
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
            180                 185                 190         
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
        195                 200                 205             
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
    210                 215                 220                 
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
225                 230                 235                 240 
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
                245                 250                 255     
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
            260                 265                 270         
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
        275                 280                 285             
Val Val Val Asp Val Ser
    290                 


<210> 36
<211> 171
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC variable region

<400> 36
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu
            20                  25                  30          
Val Lys Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
        35                  40                  45              
Met Phe Glu Arg Tyr Ser Leu His Trp Val Arg Gln Thr Pro Gly Lys
    50                  55                  60                  
Gly Leu Glu Trp Val Ser Ser Ile Ser Ser Leu Ser Gly Ser His Ile
65                  70                  75                  80  
Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
                85                  90                  95      
Ala Lys Asn Ser Leu Ser Leu Gln Met Asn Ser Leu Arg Val Glu Asp
            100                 105                 110         
Thr Ala Ile Tyr Tyr Cys Ala Arg Asp Arg Arg Ser Gly Ser Ser Pro
        115                 120                 125             
Val Pro Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
    130                 135                 140                 
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
145                 150                 155                 160 
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys
                165                 170     


<210> 37
<211> 274
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC variable region

<400> 37
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Gln Val Gln Leu Gln Glu Ser Gly Ala Gly Leu
            20                  25                  30          
Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly
        35                  40                  45              
Pro Phe Ser Gly Ala Tyr Trp Thr Trp Ile Arg Gln Thr Pro Gly Lys
    50                  55                  60                  
Gly Leu Glu Trp Ile Gly Glu Ala Gly Arg Ser Gly Thr Thr Asn Tyr
65                  70                  75                  80  
Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Leu Asp Thr Ser Lys
                85                  90                  95      
Ser Gln Phe Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala
            100                 105                 110         
Val Tyr Phe Cys Gly Arg Arg Gln Ile Met Ser Leu Ser Asn Leu Tyr
        115                 120                 125             
Lys Arg Pro Val Asp Ser Trp Gly Arg Gly Thr Pro Val Ile Val Ser
    130                 135                 140                 
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
145                 150                 155                 160 
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
                165                 170                 175     
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
            180                 185                 190         
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
        195                 200                 205             
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln
    210                 215                 220                 
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp
225                 230                 235                 240 
Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
                245                 250                 255     
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
            260                 265                 270         
Pro Xaa
        


<210> 38
<211> 279
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC variable region

<400> 38
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu
            20                  25                  30          
Val Lys Ala Gly Gly Ser Leu Lys Leu Ser Cys Gly Ala Ser Gly Phe
        35                  40                  45              
Thr Phe Ser Ser Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys
    50                  55                  60                  
Gly Leu Glu Trp Val Ser Tyr Ile Ser Ser Gly Gly Ser Ser Ile His
65                  70                  75                  80  
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala
                85                  90                  95      
Lys Asn Ser Leu Tyr Leu Gln Met Lys Asn Leu Arg Val Asp Asp Thr
            100                 105                 110         
Gly Arg Tyr Tyr Cys Val Arg Asp Pro Arg Ser Gly Ile Ser Gly Arg
        115                 120                 125             
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
    130                 135                 140                 
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
145                 150                 155                 160 
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
                165                 170                 175     
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
            180                 185                 190         
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
        195                 200                 205             
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
    210                 215                 220                 
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
225                 230                 235                 240 
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
                245                 250                 255     
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
            260                 265                 270         
Asn Pro Arg Thr Pro Ser Ser
        275                 


<210> 39
<211> 275
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC variable region

<400> 39
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val
            20                  25                  30          
Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr
        35                  40                  45              
Thr Phe Thr Lys Tyr Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln
    50                  55                  60                  
Gly Leu Glu Trp Met Gly Trp Ile Ser Ala Phe Asn Gly Tyr Thr Arg
65                  70                  75                  80  
Tyr Gly Gln Arg Phe Gln Gly Lys Val Thr Met Thr Thr Asp Thr Ser
                85                  90                  95      
Thr Asn Thr Ala Ser Leu Glu Val Arg Thr Leu Thr Ser Asn Asp Thr
            100                 105                 110         
Ala Val Tyr Tyr Cys Ala Arg Gln Tyr Pro Asp Gln Tyr Ser Ser Ser
        115                 120                 125             
Gly Trp Pro Arg Leu Phe Ala Met Asp Val Trp Gly Gln Gly Thr Thr
    130                 135                 140                 
Val Ile Val Ser Pro Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu
145                 150                 155                 160 
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys
                165                 170                 175     
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser
            180                 185                 190         
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser
        195                 200                 205             
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser
    210                 215                 220                 
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn
225                 230                 235                 240 
Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His
                245                 250                 255     
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
            260                 265                 270         
Phe Leu Phe
        275 


<210> 40
<211> 309
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC variable region

<400> 40
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
            20                  25                  30          
Val Lys Pro Gly Gly Ser Arg Arg Leu Ser Cys Ala Ala Ser Gly Phe
        35                  40                  45              
Thr Phe Ser Arg Asp Thr Met Thr Trp Val Arg Gln Ala Pro Gly Lys
    50                  55                  60                  
Gly Leu Glu Trp Val Ala Ser Ile Ser Ser Gly Ser Ser Asp Ile Asn
65                  70                  75                  80  
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly
                85                  90                  95      
Lys Asn Ser Leu Tyr Leu His Met Asn Ser Leu Arg Ala Asp Asp Thr
            100                 105                 110         
Ala Ile Tyr Tyr Cys Ala Arg Asp Pro Arg Ser Gly Ile Ser Gly Arg
        115                 120                 125             
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
    130                 135                 140                 
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
145                 150                 155                 160 
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
                165                 170                 175     
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
            180                 185                 190         
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
        195                 200                 205             
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
    210                 215                 220                 
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
225                 230                 235                 240 
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
                245                 250                 255     
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
            260                 265                 270         
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
        275                 280                 285             
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
    290                 295                 300                 
Tyr Val Asp Gly Val
305                 


<210> 41
<211> 296
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC variable region

<400> 41
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu
            20                  25                  30          
Val Lys Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
        35                  40                  45              
Thr Phe Ser Thr Tyr Ser Met Asn Trp Ile Arg Gln Ala Pro Gly Lys
    50                  55                  60                  
Gly Leu Glu Trp Val Ala Ser Ile Ser Ser Arg Ser Gly Ser His Ile
65                  70                  75                  80  
Asn Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
                85                  90                  95      
Ala Arg Asp Leu Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Asp Asp
            100                 105                 110         
Ser Ala Leu Tyr Tyr Cys Ala Arg Asp Arg Arg Ser Gly Thr Ser Pro
        115                 120                 125             
Leu Pro Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Phe Ser
    130                 135                 140                 
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
145                 150                 155                 160 
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
                165                 170                 175     
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
            180                 185                 190         
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
        195                 200                 205             
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
    210                 215                 220                 
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
225                 230                 235                 240 
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
                245                 250                 255     
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
            260                 265                 270         
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
        275                 280                 285             
Val Val Val Asp Val Ser His Glu
    290                 295     


<210> 42
<211> 295
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC variable region

<400> 42
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Gln Gly Thr Leu Arg Glu Ser Gly Pro Gly Leu
            20                  25                  30          
Val Arg Pro Ser Glu Thr Leu Ser Leu Thr Cys Gly Val Ser Gly Tyr
        35                  40                  45              
Ser Ile Ser Ser Gly Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly
    50                  55                  60                  
Lys Gly Leu Glu Trp Ile Gly Asn Ile Tyr Arg Ser Gly Ser Thr Tyr
65                  70                  75                  80  
Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Val Ser Ile Asp Thr Ser
                85                  90                  95      
Lys Asn Gln Phe Ser Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr
            100                 105                 110         
Ala Val Tyr Tyr Cys Ala Arg Ser Gly Ile Lys Val Ala Asp Asp Tyr
        115                 120                 125             
Tyr Tyr Glu Met Asp Val Trp Gly Gln Gly Thr Asp Asp Tyr Ser Tyr
    130                 135                 140                 
Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala
145                 150                 155                 160 
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser
                165                 170                 175     
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
            180                 185                 190         
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly
        195                 200                 205             
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu
    210                 215                 220                 
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr
225                 230                 235                 240 
Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg
                245                 250                 255     
Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
            260                 265                 270         
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
        275                 280                 285             
Pro Lys Asp Thr Leu Met Xaa
    290                 295 


<210> 43
<211> 283
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC variable region

<400> 43
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
            20                  25                  30          
Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe
        35                  40                  45              
Thr Phe Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys
    50                  55                  60                  
Gly Leu Glu Trp Val Ser Ser Ile Ser Ser Gly Ser Ser Tyr Ile Glu
65                  70                  75                  80  
Tyr Ala Asp Ser Val Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ala
                85                  90                  95      
Lys Lys Ser Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr
            100                 105                 110         
Ala Val Tyr Tyr Cys Ala Arg His Thr Ala Arg Ile Asp Ser Tyr His
        115                 120                 125             
Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala
    130                 135                 140                 
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser
145                 150                 155                 160 
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
                165                 170                 175     
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly
            180                 185                 190         
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu
        195                 200                 205             
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr
    210                 215                 220                 
Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg
225                 230                 235                 240 
Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
                245                 250                 255     
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
            260                 265                 270         
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
        275                 280             


<210> 44
<211> 295
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC variable region

<221> VARIANT        
<222> 271
<223> Xaa = unknown amino acid

<400> 44
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Gln Val Gln Leu Gln Glu Ser Gly Ala Gly Leu
            20                  25                  30          
Leu Lys Pro Ser Glu Thr Leu Ser Leu Ser Cys Thr Val Asp Gly Glu
        35                  40                  45              
Ser Phe Asn Gly Phe Phe Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys
    50                  55                  60                  
Gly Leu Glu Trp Ile Gly Glu Ile Asn His Leu Ala Ser Thr Gly Tyr
65                  70                  75                  80  
Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys
                85                  90                  95      
Asn Gln Phe Ser Leu Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Gly Tyr Ser Tyr Gly Phe Ala Trp Pro Asn
        115                 120                 125             
Tyr His Tyr Leu Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser
    130                 135                 140                 
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
145                 150                 155                 160 
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
                165                 170                 175     
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
            180                 185                 190         
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
        195                 200                 205             
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln
    210                 215                 220                 
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp
225                 230                 235                 240 
Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
                245                 250                 255     
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Xaa Pro
            260                 265                 270         
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
        275                 280                 285             
Cys Val Val Val Asp Val Ser
    290                 295 


<210> 45
<211> 283
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC variable region

<400> 45
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Glu Val Gln Leu Val Gln Ser Gly Gly Arg Leu
            20                  25                  30          
Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe
        35                  40                  45              
Thr Phe Ser Ser His Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys
    50                  55                  60                  
Gly Leu Glu Trp Val Ser Gly Phe Ser Gly Ser Ser Gly Thr Thr Lys
65                  70                  75                  80  
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
                85                  90                  95      
Lys Lys Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
            100                 105                 110         
Ala Val Tyr Tyr Cys Ala Lys Gly Phe Ser Pro Phe Arg Gly Val Gln
        115                 120                 125             
Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
    130                 135                 140                 
Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
145                 150                 155                 160 
Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp
                165                 170                 175     
Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr
            180                 185                 190         
Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
        195                 200                 205             
Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln
    210                 215                 220                 
Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp
225                 230                 235                 240 
Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro
                245                 250                 255     
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
            260                 265                 270         
Pro Lys Pro Arg Thr Pro Ser Ser Pro Gly Pro
        275                 280             


<210> 46
<211> 287
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC variable region

<400> 46
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu
            20                  25                  30          
Val Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ala Gly Phe
        35                  40                  45              
Thr Phe Lys Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Arg
    50                  55                  60                  
Gly Leu Glu Trp Val Ser Ser Ile Thr Ser Gly Gly Ser Lys Thr Tyr
65                  70                  75                  80  
Tyr Ala Asp Val Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala
                85                  90                  95      
Lys Gln Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
            100                 105                 110         
Ala Ile Tyr Phe Cys Ala Arg Ser Leu His Ser Thr Ser Gln Pro Ser
        115                 120                 125             
Tyr Met Asp Val Trp Gly Arg Lys Ile Thr Val Ile Val Ser Ser Ala
    130                 135                 140                 
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser
145                 150                 155                 160 
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
                165                 170                 175     
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly
            180                 185                 190         
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu
        195                 200                 205             
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr
    210                 215                 220                 
Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg
225                 230                 235                 240 
Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
                245                 250                 255     
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
            260                 265                 270         
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
        275                 280                 285         


<210> 47
<211> 290
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC variable region

<400> 47
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu
            20                  25                  30          
Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Ser Ile Ser Gly Val
        35                  40                  45              
Ser Thr Arg Asn Tyr Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys
    50                  55                  60                  
Gly Leu Glu Trp Ile Gly Tyr Ile Phe Asn Ile Gly Thr Thr Asn Tyr
65                  70                  75                  80  
Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser Val Asp Thr Ser Lys
                85                  90                  95      
Asn Gln Phe Ser Leu Lys Ile Thr Ser Val Thr Ala Ala Asp Thr Ala
            100                 105                 110         
Val Tyr Tyr Cys Ala Ser Gly Phe Glu Tyr Gly Asp Tyr Thr Phe Asp
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Ser Ala Ser Thr Lys
    130                 135                 140                 
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly
145                 150                 155                 160 
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro
                165                 170                 175     
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr
            180                 185                 190         
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
        195                 200                 205             
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn
    210                 215                 220                 
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro
225                 230                 235                 240 
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu
                245                 250                 255     
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
            260                 265                 270         
Thr Leu Met Ile Phe Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
        275                 280                 285             
Val Ser
    290 


<210> 48
<211> 276
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC variable region

<400> 48
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu
            20                  25                  30          
Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe
        35                  40                  45              
Asn Phe Asn Lys Tyr Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys
    50                  55                  60                  
Gly Leu Glu Trp Val Ser Ser Ile Ser Ala Leu Ser Thr Tyr Ile Tyr
65                  70                  75                  80  
Tyr Ala Asp Ser Leu Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala
                85                  90                  95      
Lys Asn Ser Leu Phe Leu Gln Met Asn Ser Leu Arg Asp Asp Asp Thr
            100                 105                 110         
Ala Val Tyr Tyr Cys Ala Arg Glu Ile Arg Arg Ala Ser Thr Trp Ser
        115                 120                 125             
Ala Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser
    130                 135                 140                 
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
145                 150                 155                 160 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro
                165                 170                 175     
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val
            180                 185                 190         
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser
        195                 200                 205             
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile
    210                 215                 220                 
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val
225                 230                 235                 240 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
                245                 250                 255     
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Asn Pro
            260                 265                 270         
Arg Thr Pro Ser
        275     


<210> 49
<211> 225
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC variable region

<400> 49
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu
            20                  25                  30          
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg
        35                  40                  45              
Asp Ile Asn Thr Tyr Leu Gly Trp Phe Gln Gln Arg Pro Gly Lys Ala
    50                  55                  60                  
Pro Lys Ser Leu Ile Tyr Gly Ala Ser Asn Leu Gln Asn Gly Val Pro
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr Leu Thr Ile
                85                  90                  95      
Asn Gly Leu Gln Thr Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr
            100                 105                 110         
Ser Ile Tyr Pro Leu Ser Leu Gly Gly Gly Thr Lys Ala Asp Met Lys
        115                 120                 125             
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
    130                 135                 140                 
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
145                 150                 155                 160 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
                165                 170                 175     
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
            180                 185                 190         
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
        195                 200                 205             
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
    210                 215                 220                 
Pro
225 


<210> 50
<211> 235
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC variable region

<400> 50
Met Glu Thr Asp Thr Leu Leu Leu Trp Leu Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu
            20                  25                  30          
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln
        35                  40                  45              
Ser Ile Asn Asn Trp Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Ala
    50                  55                  60                  
Pro Lys Leu Leu Ile Asn Lys Ala Ser Ser Leu Glu Ser Gly Val Pro
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile
                85                  90                  95      
Thr Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr
            100                 105                 110         
Asn Ser Asn Ser Trp Thr Phe Gly Gln Gly Thr Lys Val Asp Met Lys
        115                 120                 125             
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
    130                 135                 140                 
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
145                 150                 155                 160 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
                165                 170                 175     
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
            180                 185                 190         
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
        195                 200                 205             
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
    210                 215                 220                 
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
225                 230                 235 


<210> 51
<211> 241
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC variable region

<400> 51
Met Lys Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu
            20                  25                  30          
Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln
        35                  40                  45              
Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln
    50                  55                  60                  
Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr
65                  70                  75                  80  
Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr
                85                  90                  95      
Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val
            100                 105                 110         
Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Pro Thr Phe Gly Gln Gly
        115                 120                 125             
Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile
    130                 135                 140                 
Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val
145                 150                 155                 160 
Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys
                165                 170                 175     
Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu
            180                 185                 190         
Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu
        195                 200                 205             
Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr
    210                 215                 220                 
His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu
225                 230                 235                 240 
Cys
    


<210> 52
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC variable region

<400> 52
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Leu Pro Val Leu Thr Gln Pro Ala Ser Val Ser
            20                  25                  30          
Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser
        35                  40                  45              
Asp Val Gly Ala Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly
    50                  55                  60                  
Lys Ala Pro Lys Leu Ile Ile Tyr Glu Val Lys Ile Arg Pro Ser Gly
65                  70                  75                  80  
Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu
                85                  90                  95      
Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Phe Cys Ser
            100                 105                 110         
Ser Tyr Ser Thr Asn Ser Pro Trp Val Phe Gly Gly Gly Thr Lys Val
        115                 120                 125             
Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro
    130                 135                 140                 
Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu
145                 150                 155                 160 
Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp
                165                 170                 175     
Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln
            180                 185                 190         
Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu
        195                 200                 205             
Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly
    210                 215                 220                 
Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser
225                 230                 235         


<210> 53
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC variable region

<400> 53
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu
            20                  25                  30          
Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln
        35                  40                  45              
Ser Val Thr Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
    50                  55                  60                  
Ala Pro Thr Leu Val Ile Tyr Asp Ala Ser Thr Arg Ala Ser Gly Ile
65                  70                  75                  80  
Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
                85                  90                  95      
Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln
            100                 105                 110         
Tyr Gly Ser Ser Pro Pro Tyr Thr Phe Gly Arg Gly Thr Lys Leu Glu
        115                 120                 125             
Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser
    130                 135                 140                 
Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn
145                 150                 155                 160 
Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala
                165                 170                 175     
Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys
            180                 185                 190         
Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp
        195                 200                 205             
Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu
    210                 215                 220                 
Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
225                 230                 235         


<210> 54
<211> 238
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC variable region

<400> 54
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu
            20                  25                  30          
Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln
        35                  40                  45              
Thr Val Leu Phe Thr Ser Tyr Tyr Val Ala Trp Tyr Gln Gln Lys Pro
    50                  55                  60                  
Gly Gln Pro Pro Lys Leu Leu Phe Ser Gly Ala Ser Ser Arg Glu Ser
65                  70                  75                  80  
Gly Val Pro Asp Arg Phe Ser Ala Gly Gly Ser Gly Thr Asp Phe Tyr
                85                  90                  95      
Leu Thr Ile Asn Ser Leu Gln Ala Glu Asp Val Ala Asp Tyr Tyr Cys
            100                 105                 110         
Gln Gln Tyr His Thr Pro Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu
        115                 120                 125             
Glu Ile Arg Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro
    130                 135                 140                 
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu
145                 150                 155                 160 
Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn
                165                 170                 175     
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
            180                 185                 190         
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala
        195                 200                 205             
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly
    210                 215                 220                 
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
225                 230                 235             


<210> 55
<211> 235
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC variable region

<400> 55
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu
            20                  25                  30          
Ser Val Ser Pro Gly Glu Thr Ala Thr Leu Ser Cys Arg Ala Ser Gln
        35                  40                  45              
Asn Val Ile Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala
    50                  55                  60                  
Pro Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro
65                  70                  75                  80  
Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile
                85                  90                  95      
Ser Ser Met Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr
            100                 105                 110         
Asn Asp Trp Pro Arg Ser Phe Gly Gln Gly Thr Arg Leu Asp Ile Arg
        115                 120                 125             
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
    130                 135                 140                 
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
145                 150                 155                 160 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
                165                 170                 175     
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
            180                 185                 190         
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
        195                 200                 205             
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
    210                 215                 220                 
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
225                 230                 235 


<210> 56
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC variable region

<400> 56
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Asp Ile Val Leu Thr Gln Ser Pro Gly Thr Leu
            20                  25                  30          
Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln
        35                  40                  45              
Ser Val Asn Ser Ile Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
    50                  55                  60                  
Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile
65                  70                  75                  80  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
                85                  90                  95      
Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln
            100                 105                 110         
Tyr His Ser Ser Pro Lys Leu Thr Phe Gly Gly Gly Thr Lys Val Glu
        115                 120                 125             
Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser
    130                 135                 140                 
Gly Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn
145                 150                 155                 160 
Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala
                165                 170                 175     
Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys
            180                 185                 190         
Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp
        195                 200                 205             
Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu
    210                 215                 220                 
Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
225                 230                 235         


<210> 57
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC variable region

<400> 57
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser
            20                  25                  30          
Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Gly Ser
        35                  40                  45              
Asp Ile Gly Gly Tyr Asn Phe Val Ser Trp Tyr Gln Gln Tyr Pro Gly
    50                  55                  60                  
Lys Ala Pro Lys Leu Ile Ile Tyr Glu Val Arg Ile Arg Ala Ser Gly
65                  70                  75                  80  
Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu
                85                  90                  95      
Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn
            100                 105                 110         
Ser Tyr Ser Ile His Ser Pro Trp Val Phe Gly Gly Gly Thr Lys Leu
        115                 120                 125             
Thr Val Leu Arg Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro
    130                 135                 140                 
Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu
145                 150                 155                 160 
Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp
                165                 170                 175     
Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln
            180                 185                 190         
Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu
        195                 200                 205             
Gln Trp Glu Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly
    210                 215                 220                 
Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser
225                 230                 235         


<210> 58
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC variable region

<400> 58
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Gln Ala Gly Leu Thr Gln Pro Ala Ser Val Ser
            20                  25                  30          
Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Ala Ala Asn Ser
        35                  40                  45              
Asp Ile Gly Asp Phe Asn Phe Val Ser Trp Tyr Gln Gln Arg Pro Asp
    50                  55                  60                  
Lys Ala Pro Lys Leu Met Val Tyr Glu Val Ser Ser Arg Pro Ser Gly
65                  70                  75                  80  
Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu
                85                  90                  95      
Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Thr
            100                 105                 110         
Ser Tyr Thr Ser Ser Ser Thr Phe Val Phe Gly Thr Gly Thr Lys Val
        115                 120                 125             
Thr Val Leu Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro
    130                 135                 140                 
Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu
145                 150                 155                 160 
Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp
                165                 170                 175     
Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln
            180                 185                 190         
Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu
        195                 200                 205             
Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly
    210                 215                 220                 
Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser
225                 230                 235         


<210> 59
<211> 236
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC variable region

<400> 59
Thr Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val
 1               5                  10                  15      
Pro Gly Ser Thr Gly Asp Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr
            20                  25                  30          
Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser
        35                  40                  45              
Gln Ser Val Ser Ser Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly
    50                  55                  60                  
Gln Ser Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly
65                  70                  75                  80  
Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu
                85                  90                  95      
Thr Ile Asn Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln
            100                 105                 110         
Gln Phe Gly Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
        115                 120                 125             
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
    130                 135                 140                 
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
145                 150                 155                 160 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu
                165                 170                 175     
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
            180                 185                 190         
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr
        195                 200                 205             
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
    210                 215                 220                 
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
225                 230                 235     


<210> 60
<211> 235
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC variable region

<400> 60
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Glu Thr Thr Leu Thr Gln Ser Pro Ala Thr Leu
            20                  25                  30          
Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln
        35                  40                  45              
Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala
    50                  55                  60                  
Pro Arg Leu Leu Ile Tyr Gly Ala Ser Lys Arg Ala Thr Gly Ile Pro
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile
                85                  90                  95      
Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Arg
            100                 105                 110         
Ser Asp Trp Arg Thr Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
        115                 120                 125             
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
    130                 135                 140                 
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
145                 150                 155                 160 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
                165                 170                 175     
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
            180                 185                 190         
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
        195                 200                 205             
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
    210                 215                 220                 
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
225                 230                 235 


<210> 61
<211> 235
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC variable region

<400> 61
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Asp Ile Val Met Thr Gln Ser Pro Ser Thr Leu
            20                  25                  30          
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln
        35                  40                  45              
Ser Ile Asp Arg Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala
    50                  55                  60                  
Pro Lys Leu Leu Ile Tyr Gln Ala Ser Ser Leu Glu Arg Gly Val Pro
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile
                85                  90                  95      
Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr
            100                 105                 110         
Asn Gly Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
        115                 120                 125             
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
    130                 135                 140                 
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
145                 150                 155                 160 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
                165                 170                 175     
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
            180                 185                 190         
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
        195                 200                 205             
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
    210                 215                 220                 
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
225                 230                 235 


<210> 62
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC variable region

<400> 62
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Asp Ile Gln Met Thr Gln Ser Pro Gly Thr Leu
            20                  25                  30          
Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln
        35                  40                  45              
Ser Val Ile Ser Tyr Tyr Val Ala Trp Tyr Gln His Lys Gly Gly Gln
    50                  55                  60                  
Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Val
65                  70                  75                  80  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
                85                  90                  95      
Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Leu Tyr Tyr Cys Gln Tyr
            100                 105                 110         
Tyr Gly Ser Ser Pro Leu Trp Ala Phe Gly Gln Gly Thr Lys Val Glu
        115                 120                 125             
Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser
    130                 135                 140                 
Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn
145                 150                 155                 160 
Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala
                165                 170                 175     
Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys
            180                 185                 190         
Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp
        195                 200                 205             
Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu
    210                 215                 220                 
Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
225                 230                 235         


<210> 63
<211> 235
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC variable region

<400> 63
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu
            20                  25                  30          
Ser Val Ser Pro Gly Gly Arg Ala Ser Leu Ser Cys Arg Ala Ser Gln
        35                  40                  45              
Ser Ile Gly Asp Lys Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala
    50                  55                  60                  
Pro Arg Leu Val Ile Tyr Gly Ala Tyr Thr Arg Ala Thr Asp Ile Ser
65                  70                  75                  80  
Pro Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Asn Leu Thr Ile
                85                  90                  95      
Ser Arg Met Gln Ser Gly Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr
            100                 105                 110         
Glu Asn Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
        115                 120                 125             
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
    130                 135                 140                 
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
145                 150                 155                 160 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
                165                 170                 175     
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
            180                 185                 190         
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
        195                 200                 205             
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
    210                 215                 220                 
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
225                 230                 235 


<210> 64
<211> 291
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC variable region

<400> 64
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly Asp Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
            20                  25                  30          
Ser Ala Ser Val Gly Asp Arg Val Ile Ile Thr Cys Arg Ala Ser Gln
        35                  40                  45              
Ser Ile Ser Ser Ser Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala
    50                  55                  60                  
Pro Lys Leu Leu Ile Tyr Ala Ala Val Asn Leu Glu Thr Gly Val Pro
65                  70                  75                  80  
Ser Arg Phe Ser Gly Ser Gly Phe Gly Thr Asp Phe Thr Leu Ala Ile
                85                  90                  95      
Ser Asn Val Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser
            100                 105                 110         
Asp Thr Arg Thr Phe Gly Arg Gly Thr Lys Leu Asp Val Lys Arg Thr
        115                 120                 125             
Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu
    130                 135                 140                 
Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro
145                 150                 155                 160 
Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly
                165                 170                 175     
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr
            180                 185                 190         
Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His
        195                 200                 205             
Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val
    210                 215                 220                 
Thr Lys Ser Phe Asn Arg Gly Glu Val Leu Gly Gly Arg Lys Leu Gly
225                 230                 235                 240 
Arg His Gly Pro Thr Cys Leu Leu Gln Leu Ile Met Val Thr Asn Lys
                245                 250                 255     
Ala Ile Ala Ser Gln Ile Ser Gln Ile Lys His Phe Phe His Cys Ile
            260                 265                 270         
Leu Val Val Val Cys Pro Asn Ser Ser Met Tyr Leu Ile Met Ser Gly
        275                 280                 285             
Ser Gly Ile
    290     


<210> 65
<211> 8
<212> PRT
<213> human

<400> 65
Gly Phe Asn Phe Arg Ala Tyr Gly
 1               5              


<210> 66
<211> 9
<212> PRT
<213> human

<400> 66
Ile Trp Ser Ala Glu Thr Asn Arg His
 1               5                  


<210> 67
<211> 13
<212> PRT
<213> human

<400> 67
Ala Lys Ala Arg Pro Gly Tyr Asp Tyr Val Val Asp Leu
 1               5                  10              


<210> 68
<211> 8
<212> PRT
<213> human

<400> 68
Gly Phe Ser Phe Ser Ser Tyr Ser
 1               5              


<210> 69
<211> 9
<212> PRT
<213> human

<400> 69
Ile Asn Ser Asp Gly Ser Thr Lys Ile
 1               5                  


<210> 70
<211> 12
<212> PRT
<213> human

<400> 70
Val Arg Leu Val His Tyr Asp Trp Ser Pro Phe Val
 1               5                  10          


<210> 71
<211> 8
<212> PRT
<213> human

<400> 71
Gly Phe Thr Phe Thr Arg Phe Thr
 1               5              


<210> 72
<211> 9
<212> PRT
<213> human

<400> 72
Ile Ser Ser Gly Ser Ser Asp Ile Asn
 1               5                  


<210> 73
<211> 16
<212> PRT
<213> human

<400> 73
Ala Lys Asp Pro Arg Ser Gly Ile Ser Gly Arg Tyr Gly Met Asp Val
 1               5                  10                  15      


<210> 74
<211> 8
<212> PRT
<213> human

<400> 74
Gly Phe Met Phe Glu Arg Tyr Ser
 1               5              


<210> 75
<211> 10
<212> PRT
<213> human

<400> 75
Ile Ser Ser Leu Ser Gly Ser His Ile Asn
 1               5                  10  


<210> 76
<211> 15
<212> PRT
<213> human

<400> 76
Ala Arg Asp Arg Arg Ser Gly Ser Ser Pro Val Pro Leu Asp Val
 1               5                  10                  15  


<210> 77
<211> 8
<212> PRT
<213> human

<400> 77
Gly Gly Pro Phe Ser Gly Ala Tyr
 1               5              


<210> 78
<211> 8
<212> PRT
<213> human

<400> 78
Ala Gly Arg Ser Gly Thr Thr Asn
 1               5              


<210> 79
<211> 18
<212> PRT
<213> human

<400> 79
Gly Arg Arg Gln Ile Met Ser Leu Ser Asn Leu Tyr Lys Arg Pro Val
 1               5                  10                  15      
Asp Ser
        


<210> 80
<211> 8
<212> PRT
<213> human

<400> 80
Gly Phe Thr Phe Ser Ser Tyr Ser
 1               5              


<210> 81
<211> 9
<212> PRT
<213> human

<400> 81
Ile Ser Ser Gly Gly Ser Ser Ile His
 1               5                  


<210> 82
<211> 16
<212> PRT
<213> human

<400> 82
Val Arg Asp Pro Arg Ser Gly Ile Ser Gly Arg Tyr Gly Met Asp Val
 1               5                  10                  15      


<210> 83
<211> 8
<212> PRT
<213> human

<400> 83
Gly Tyr Thr Phe Thr Lys Tyr Gly
 1               5              


<210> 84
<211> 9
<212> PRT
<213> human

<400> 84
Ile Ser Ala Phe Asn Gly Tyr Thr Arg
 1               5                  


<210> 85
<211> 21
<212> PRT
<213> human

<400> 85
Ala Arg Gln Tyr Pro Asp Gln Tyr Ser Ser Ser Gly Trp Pro Arg Leu
 1               5                  10                  15      
Phe Ala Met Asp Val
            20      


<210> 86
<211> 8
<212> PRT
<213> human

<400> 86
Gly Phe Thr Phe Ser Arg Asp Thr
 1               5              


<210> 87
<211> 9
<212> PRT
<213> human

<400> 87
Ile Ser Ser Gly Ser Ser Asp Ile Asn
 1               5                  


<210> 88
<211> 16
<212> PRT
<213> human

<400> 88
Ala Arg Asp Pro Arg Ser Gly Ile Ser Gly Arg Tyr Gly Met Asp Val
 1               5                  10                  15      


<210> 89
<211> 8
<212> PRT
<213> human

<400> 89
Gly Phe Thr Phe Ser Thr Tyr Ser
 1               5              


<210> 90
<211> 10
<212> PRT
<213> human

<400> 90
Ile Ser Ser Arg Ser Gly Ser His Ile Asn
 1               5                  10  


<210> 91
<211> 15
<212> PRT
<213> human

<400> 91
Ala Arg Asp Arg Arg Ser Gly Thr Ser Pro Leu Pro Leu Asp Val
 1               5                  10                  15  


<210> 92
<211> 9
<212> PRT
<213> human

<400> 92
Gly Tyr Ser Ile Ser Ser Gly Tyr Tyr
 1               5                  


<210> 93
<211> 8
<212> PRT
<213> human

<400> 93
Ile Tyr Arg Ser Gly Ser Thr Tyr
 1               5              


<210> 94
<211> 31
<212> PRT
<213> human

<400> 94
Ala Arg Ser Gly Ile Lys Val Ala Asp Asp Tyr Tyr Tyr Glu Met Asp
 1               5                  10                  15      
Val Trp Gly Gln Gly Thr Asp Asp Tyr Ser Tyr Ala Met Asp Val
            20                  25                  30      


<210> 95
<211> 8
<212> PRT
<213> human

<400> 95
Gly Phe Thr Phe Ser Ser Tyr Ser
 1               5              


<210> 96
<211> 9
<212> PRT
<213> human

<400> 96
Ile Ser Ser Gly Ser Ser Tyr Ile Glu
 1               5                  


<210> 97
<211> 15
<212> PRT
<213> human

<400> 97
Ala Arg His Thr Ala Arg Ile Asp Ser Tyr His Gly Met Asp Val
 1               5                  10                  15  


<210> 98
<211> 8
<212> PRT
<213> human

<400> 98
Gly Glu Ser Phe Asn Gly Phe Phe
 1               5              


<210> 99
<211> 8
<212> PRT
<213> human

<400> 99
Ile Asn His Leu Ala Ser Thr Gly
 1               5              


<210> 100
<211> 18
<212> PRT
<213> human

<400> 100
Ala Arg Gly Tyr Ser Tyr Gly Phe Ala Trp Pro Asn Tyr His Tyr Leu
 1               5                  10                  15      
Asp Val
        


<210> 101
<211> 8
<212> PRT
<213> human

<400> 101
Gly Phe Thr Phe Ser Ser His Ala
 1               5              


<210> 102
<211> 9
<212> PRT
<213> human

<400> 102
Phe Ser Gly Ser Ser Gly Thr Thr Lys
 1               5                  


<210> 103
<211> 17
<212> PRT
<213> human

<400> 103
Ala Lys Gly Phe Ser Pro Phe Arg Gly Val Gln Phe Pro Tyr Phe Asp
 1               5                  10                  15      
Tyr
    


<210> 104
<211> 8
<212> PRT
<213> human

<400> 104
Gly Phe Thr Phe Lys Ser Tyr Ser
 1               5              


<210> 105
<211> 9
<212> PRT
<213> human

<400> 105
Ile Thr Ser Gly Gly Ser Lys Thr Tyr
 1               5                  


<210> 106
<211> 15
<212> PRT
<213> human

<400> 106
Ala Arg Ser Leu His Ser Thr Ser Gln Pro Ser Tyr Met Asp Val
 1               5                  10                  15  


<210> 107
<211> 8
<212> PRT
<213> human

<400> 107
Gly Val Ser Thr Arg Asn Tyr Tyr
 1               5              


<210> 108
<211> 8
<212> PRT
<213> human

<400> 108
Ile Phe Asn Ile Gly Thr Thr Asn
 1               5              


<210> 109
<211> 13
<212> PRT
<213> human

<400> 109
Ala Ser Gly Phe Glu Tyr Gly Asp Tyr Thr Phe Asp Tyr
 1               5                  10              


<210> 110
<211> 8
<212> PRT
<213> human

<400> 110
Gly Phe Asn Phe Asn Lys Tyr Asn
 1               5              


<210> 111
<211> 9
<212> PRT
<213> human

<400> 111
Ile Ser Ala Leu Ser Thr Tyr Ile Tyr
 1               5                  


<210> 112
<211> 14
<212> PRT
<213> human

<400> 112
Ala Arg Glu Ile Arg Arg Ala Ser Thr Trp Ser Ala Asp Leu
 1               5                  10                  


<210> 113
<211> 6
<212> PRT
<213> human

<400> 113
Arg Asp Ile Asn Thr Tyr
 1               5      


<210> 114
<211> 9
<212> PRT
<213> human

<400> 114
Gln Gln Tyr Ser Ile Tyr Pro Leu Ser
 1               5                  


<210> 115
<211> 6
<212> PRT
<213> human

<400> 115
Gln Ser Ile Asn Asn Trp
 1               5      


<210> 116
<211> 9
<212> PRT
<213> human

<400> 116
Gln Gln Tyr Asn Ser Asn Ser Trp Thr
 1               5                  


<210> 117
<211> 12
<212> PRT
<213> human

<400> 117
Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr
 1               5                  10          


<210> 118
<211> 9
<212> PRT
<213> human

<400> 118
Gln Gln Tyr Tyr Ser Thr Pro Pro Thr
 1               5                  


<210> 119
<211> 9
<212> PRT
<213> human

<400> 119
Ser Ser Asp Val Gly Ala Tyr Asn Tyr
 1               5                  


<210> 120
<211> 10
<212> PRT
<213> human

<400> 120
Ser Ser Tyr Ser Thr Asn Ser Pro Trp Val
 1               5                  10  


<210> 121
<211> 7
<212> PRT
<213> human

<400> 121
Gln Ser Val Thr Lys Asn Tyr
 1               5          


<210> 122
<211> 10
<212> PRT
<213> human

<400> 122
His Gln Tyr Gly Ser Ser Pro Pro Tyr Thr
 1               5                  10  


<210> 123
<211> 9
<212> PRT
<213> human

<400> 123
Gln Thr Val Leu Phe Thr Ser Tyr Tyr
 1               5                  


<210> 124
<211> 9
<212> PRT
<213> human

<400> 124
Gln Gln Tyr His Thr Pro Pro Phe Thr
 1               5                  


<210> 125
<211> 6
<212> PRT
<213> human

<400> 125
Gln Asn Val Ile Asn Asn
 1               5      


<210> 126
<211> 9
<212> PRT
<213> human

<400> 126
Gln Gln Tyr Asn Asp Trp Pro Arg Ser
 1               5                  


<210> 127
<211> 7
<212> PRT
<213> human

<400> 127
Gln Ser Val Asn Ser Ile Phe
 1               5          


<210> 128
<211> 10
<212> PRT
<213> human

<400> 128
Gln Gln Tyr His Ser Ser Pro Lys Leu Thr
 1               5                  10  


<210> 129
<211> 9
<212> PRT
<213> human

<400> 129
Gly Ser Asp Ile Gly Gly Tyr Asn Phe
 1               5                  


<210> 130
<211> 10
<212> PRT
<213> human

<400> 130
Asn Ser Tyr Ser Ile His Ser Pro Trp Val
 1               5                  10  


<210> 131
<211> 9
<212> PRT
<213> human

<400> 131
Asn Ser Asp Ile Gly Asp Phe Asn Phe
 1               5                  


<210> 132
<211> 10
<212> PRT
<213> human

<400> 132
Thr Ser Tyr Thr Ser Ser Ser Thr Phe Val
 1               5                  10  


<210> 133
<211> 7
<212> PRT
<213> human

<400> 133
Gln Ser Val Ser Ser Thr Tyr
 1               5          


<210> 134
<211> 8
<212> PRT
<213> human

<400> 134
Gln Gln Phe Gly Ser Pro Trp Thr
 1               5              


<210> 135
<211> 6
<212> PRT
<213> human

<400> 135
Gln Ser Val Ser Ser Tyr
 1               5      


<210> 136
<211> 9
<212> PRT
<213> human

<400> 136
Gln His Arg Ser Asp Trp Arg Thr Thr
 1               5                  


<210> 137
<211> 6
<212> PRT
<213> human

<400> 137
Gln Ser Ile Asp Arg Trp
 1               5      


<210> 138
<211> 9
<212> PRT
<213> human

<400> 138
Gln Gln Tyr Asn Gly Tyr Pro Leu Thr
 1               5                  


<210> 139
<211> 7
<212> PRT
<213> human

<400> 139
Gln Ser Val Ile Ser Tyr Tyr
 1               5          


<210> 140
<211> 10
<212> PRT
<213> human

<400> 140
Gln Tyr Tyr Gly Ser Ser Pro Leu Trp Ala
 1               5                  10  


<210> 141
<211> 6
<212> PRT
<213> human

<400> 141
Gln Ser Ile Gly Asp Lys
 1               5      


<210> 142
<211> 9
<212> PRT
<213> human

<400> 142
Gln Gln Tyr Glu Asn Trp Pro Arg Thr
 1               5                  


<210> 143
<211> 6
<212> PRT
<213> human

<400> 143
Gln Ser Ile Ser Ser Ser
 1               5      


<210> 144
<211> 7
<212> PRT
<213> human

<400> 144
Gln Gln Ser Asp Thr Arg Thr
 1               5          

