                         SEQUENCE LISTING

<110>  National University of Singapore
 
<120>  ANTI-CANCER COMPOUNDS AND USES THEREOF

<130>  FP9297

<150>  10201610300X
<151>  2016-12-08

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA target human PI5P4K alpha, pool #1

<400>  1
ctgcccgatg gtcttccgta a                                                 21


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA target human PI5P4K beta, pool #1

<400>  2
cacgatcaat gagctgagca a                                                 21


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA target human PI5P4K gamma, pool #1

<400>  3
ccggagcagt atgctaagcg a                                                 21


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA target human PI5P4K alpha, pool #2

<400>  4
cggcttaatg ttgatggagt t                                                 21


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA target human PI5P4K beta, pool #2

<400>  5
ccctcgatct atttccttct t                                                 21


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA target human PI5P4K alpha, pool #3

<400>  6
cctcggacag acatgaacat t                                                 21


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA target human PI5P4K beta, pool #3

<400>  7
caaacgcttc aacgagttta t                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA target human PI5P4K gamma, pool #3

<400>  8
ccgagtcagt gtggacaacg a                                                 21


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA target human PIK3IP1, #1

<400>  9
agaggctaac ctggaaacta a                                                 21


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA target human PIK3IP1, #2

<400>  10
tacactgtta ttcatggtta a                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PI5P4K alpha forward primer

<400>  11
aagaagaagc acttcgtagc g                                                 21


<210>  12
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PI5P4K alpha reverse primer

<400>  12
atggctcagt tcattgatcg ag                                                22


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PI5P4K beta forward primer

<400>  13
ccacacgatc aatgagctga g                                                 21


<210>  14
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PI5P4K beta reverse primer

<400>  14
tccttaaact taaagcggct gg                                                22


<210>  15
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PI5P4K gamma forward primer

<400>  15
ccgggaagcc agcgataag                                                    19


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PI5P4K gamma reverse primer

<400>  16
agctgcacta gaaactccac a                                                 21


<210>  17
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PIK3IP1 forward primer

<400>  17
gctaggagga actaccactt tg                                                22


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PIK3IP1 reverse primer

<400>  18
gatggacaag gagcactgtt a                                                 21


<210>  19
<211>  3833
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (249)..(1469)

<400>  19
gcgggctgag cgcggatccg cggcgggcgc aggatacggg ccggggcgcg agccgagcgc       60

agtctgccgg gccgagcggg cggagcgagc cgagtggggc tgagcgcgcc ggcggcggcg      120

ggcggagcgg agcgcggcgc gccggggccg ccgccggggg gatgcggctg cctccccggg      180

ccggggtgta gagagggcgg gtccccggcc tcgggagcac ggcggtggag gggacatagg      240

aggcggcc atg gcg acc ccc ggc aac cta ggg tcc tct gtc ctg gcg agc       290
         Met Ala Thr Pro Gly Asn Leu Gly Ser Ser Val Leu Ala Ser          
         1               5                   10                           

aag acc aag acc aag aag aag cac ttc gta gcg cag aaa gtg aag ctg        338
Lys Thr Lys Thr Lys Lys Lys His Phe Val Ala Gln Lys Val Lys Leu           
15                  20                  25                  30            

ttt cgg gcc agc gac ccg ctg ctc agc gtc ctc atg tgg ggg gta aac        386
Phe Arg Ala Ser Asp Pro Leu Leu Ser Val Leu Met Trp Gly Val Asn           
                35                  40                  45                

cac tcg atc aat gaa ctg agc cat gtt caa atc cct gtt atg ttg atg        434
His Ser Ile Asn Glu Leu Ser His Val Gln Ile Pro Val Met Leu Met           
            50                  55                  60                    

cca gat gac ttc aaa gcc tat tca aaa ata aag gtg gac aat cac ctt        482
Pro Asp Asp Phe Lys Ala Tyr Ser Lys Ile Lys Val Asp Asn His Leu           
        65                  70                  75                        

ttt aac aaa gaa aac atg ccg agc cat ttc aag ttt aag gaa tac tgc        530
Phe Asn Lys Glu Asn Met Pro Ser His Phe Lys Phe Lys Glu Tyr Cys           
    80                  85                  90                            

ccg atg gtc ttc cgt aac ctg cgg gag agg ttt gga att gat gat caa        578
Pro Met Val Phe Arg Asn Leu Arg Glu Arg Phe Gly Ile Asp Asp Gln           
95                  100                 105                 110           

gat ttc cag aat tcc ctg acc agg agc gca ccc ctc ccc aac gac tcc        626
Asp Phe Gln Asn Ser Leu Thr Arg Ser Ala Pro Leu Pro Asn Asp Ser           
                115                 120                 125               

cag gcc cgc agt gga gct cgt ttt cac act tcc tac gac aaa aga tac        674
Gln Ala Arg Ser Gly Ala Arg Phe His Thr Ser Tyr Asp Lys Arg Tyr           
            130                 135                 140                   

atc atc aag act att acc agt gaa gac gtg gcc gaa atg cac aac atc        722
Ile Ile Lys Thr Ile Thr Ser Glu Asp Val Ala Glu Met His Asn Ile           
        145                 150                 155                       

ctg aag aaa tac cac cag tac ata gtg gaa tgt cat ggg atc acc ctt        770
Leu Lys Lys Tyr His Gln Tyr Ile Val Glu Cys His Gly Ile Thr Leu           
    160                 165                 170                           

ctt ccc cag ttc ttg ggc atg tac cgg ctt aat gtt gat gga gtt gaa        818
Leu Pro Gln Phe Leu Gly Met Tyr Arg Leu Asn Val Asp Gly Val Glu           
175                 180                 185                 190           

ata tat gtg ata gtt aca aga aat gta ttc agc cac cgt ttg tct gtg        866
Ile Tyr Val Ile Val Thr Arg Asn Val Phe Ser His Arg Leu Ser Val           
                195                 200                 205               

tat agg aaa tac gac tta aag ggc tct aca gtg gct aga gaa gct agt        914
Tyr Arg Lys Tyr Asp Leu Lys Gly Ser Thr Val Ala Arg Glu Ala Ser           
            210                 215                 220                   

gac aaa gaa aag gcc aaa gaa ctg cca act ctg aaa gat aat gat ttc        962
Asp Lys Glu Lys Ala Lys Glu Leu Pro Thr Leu Lys Asp Asn Asp Phe           
        225                 230                 235                       

att aat gag ggc caa aag att tat att gat gac aac aac aag aag gtc       1010
Ile Asn Glu Gly Gln Lys Ile Tyr Ile Asp Asp Asn Asn Lys Lys Val           
    240                 245                 250                           

ttc ctg gaa aaa cta aaa aag gat gtt gag ttt ctg gcc cag ctg aag       1058
Phe Leu Glu Lys Leu Lys Lys Asp Val Glu Phe Leu Ala Gln Leu Lys           
255                 260                 265                 270           

ctc atg gac tac agt ctg ctg gtg gga att cat gat gtg gag aga gcc       1106
Leu Met Asp Tyr Ser Leu Leu Val Gly Ile His Asp Val Glu Arg Ala           
                275                 280                 285               

gaa cag gag gaa gtg gag tgt gag gag aac gat ggg gag gag gag ggc       1154
Glu Gln Glu Glu Val Glu Cys Glu Glu Asn Asp Gly Glu Glu Glu Gly           
            290                 295                 300                   

gag agc gat ggc acc cac ccg gtg gga acc ccc cca gat agc ccc ggg       1202
Glu Ser Asp Gly Thr His Pro Val Gly Thr Pro Pro Asp Ser Pro Gly           
        305                 310                 315                       

aat aca ctg aac agc tca cca ccc ctg gct ccc ggg gag ttc gat ccg       1250
Asn Thr Leu Asn Ser Ser Pro Pro Leu Ala Pro Gly Glu Phe Asp Pro           
    320                 325                 330                           

aac atc gac gtc tat gga att aag tgc cat gaa aac tcg cct agg aag       1298
Asn Ile Asp Val Tyr Gly Ile Lys Cys His Glu Asn Ser Pro Arg Lys           
335                 340                 345                 350           

gag gtg tac ttc atg gca att att gac atc ctt act cat tat gat gca       1346
Glu Val Tyr Phe Met Ala Ile Ile Asp Ile Leu Thr His Tyr Asp Ala           
                355                 360                 365               

aaa aag aaa gct gcc cat gct gca aaa act gtt aaa cat ggc gct ggc       1394
Lys Lys Lys Ala Ala His Ala Ala Lys Thr Val Lys His Gly Ala Gly           
            370                 375                 380                   

gcg gag atc tcc acc gtg aac cca gaa cag tat tca aag cgc ttt ttg       1442
Ala Glu Ile Ser Thr Val Asn Pro Glu Gln Tyr Ser Lys Arg Phe Leu           
        385                 390                 395                       

gac ttt att ggc cac atc ttg acg taa cctcctgcgc agcctcggac             1489
Asp Phe Ile Gly His Ile Leu Thr                                           
    400                 405                                               

agacatgaac attggatgga cagaggtggc ttcggtgtag gaaaaatgaa aaccaaactc     1549

agtgaagtac tcatcttgca ggaagcaaac ctccttgttt acatcttcag gccaagatga     1609

ctgatttggg ggctactcgc tttacagcta cctgattttc ccagcatcgt tctagctatt     1669

tctgactttg tgtatatgtg tgtgtgtgtg tgttgggggg gggtgagtgt gtgcgcgcgt     1729

gtgcatttta aaagtcataa attaattaaa acagatccac ttcggtcagt atgtgtccca     1789

acaaagaccc tttgattcca gctatggccg aatgaatgag tgagtgagtg agtgagtgaa     1849

tgaacacacg tgtgggggag gggagaagga agtgcatgat gtcaggcacc gtgttggcat     1909

cacacaacaa actgtggatc agtttttttt tttttttttt ttttttggag ttgaaagatg     1969

tgagacagta ttcagaataa tgaagataat aatgatgatt attataataa tgatgatgat     2029

tccaaggaaa aaacctacag cgaatgttcc atttctaccc cgcacgcaga cactctccct     2089

aacactgata acctgagccc ccagcactgg acggaagaat gctggcgtct ccgtgtgtac     2149

tggttcaggg ttctggcccc agccttgtca ggaccccctg gtgtccagag cccccacccc     2209

tcccgcaaca agcagctgat gccccagtga ttctctatac atttttcacc tcggccaata     2269

tgtccaggaa aactgcttac ttctcttttc ttgcctggag ccttcattgt tcacccttac     2329

gttgcaatat aggaattaat gctacaaaat aaaagtaaag cttacctgaa aagtgcatag     2389

tttggggcaa tggtatctac atctcccact gtgggaaaac cagcaaagca tcaaaactct     2449

caattctcct gttaccaaat gcagatctga attataagat gtttatgttt gaccattgtt     2509

tcaacaatgg gattttgtta cgaattatcc ctttaactga aaccctcagt tttactgttt     2569

acattattag gaaaacaggg atatcttttg aatctaaaaa tttgatgtac agcatgtgat     2629

ttttgaagtt tacatgtaaa gtcacagtat aggtgaaata acgtttgtca tattttgaga     2689

cgtatcctgc agccatgttt ttacgtgagt gttttagtca aagtacatgg tagacagtct     2749

ttcacaataa aaggaaaagg attttttttt cctccaaatg tacatttatc aacctaatga     2809

ttgatttttt taaaaagaga tttcgcccca gtctggttta tgaaagttca ttgccctaaa     2869

ctgtgctgat tgtttttaat caagttataa atttccaacc tagatcatgt atctaccaac     2929

tctcctgcat tttccaaaag gcattgagct taaatattag tcttgcttag agtaggttat     2989

ccacttacat gctgcgctaa agccatgcct ttgaaactcc ttgtttaaaa catgatatga     3049

tttttgtggg cagtttcaga aaagaaaaca aacaaacaaa aatcgaccct ttaattatta     3109

cttgcaactc aacagatctc cctgccgtac tgccttttcc aggaacttta cttcagggct     3169

gtccagattg cagctgtgcc ccgtgtatgt ggatctagtt cacagagtct ttggaagcca     3229

gcagtcgtgc cctccgtata ctgtccactc attttatgta gatttggtat cctcagcagc     3289

cagtgttaac accactgtca cgtagtgtac agattcatct tttatgtatt taaagtaatc     3349

catactatga tttggttttt ccctgcacca ttaattctgg catcagatca gtttttgtgt     3409

tgtgaagttc tactgtggtt tgacccaaga ccacaaccat gagaccctga agtaaagata     3469

aggtacacat acattatttg agtaactgtt tccttggggg ccaatctgtg tatgctttta     3529

gaagtttaca gaatgctttt atttttgtct ataacaaaca gtctgtcatt tatttctgtt     3589

gataaaccat ttggacagag tgaggacgtt tgccctgtta tctcctagtg ctaacaatac     3649

actccagtca tgagccgggc tttacaaata aagcactttt gatgactcac aagatgaatc     3709

cttttttcct ctgtcccaat tgtgtgtctc tgttccaaac acattttaaa tactcggtcc     3769

tgacagtgtc tttagctaat ccttgaagaa atgaaagtgg aattgaatct ttttagtttc     3829

taga                                                                  3833


<210>  20
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Thr Pro Gly Asn Leu Gly Ser Ser Val Leu Ala Ser Lys Thr 
1               5                   10                  15      


Lys Thr Lys Lys Lys His Phe Val Ala Gln Lys Val Lys Leu Phe Arg 
            20                  25                  30          


Ala Ser Asp Pro Leu Leu Ser Val Leu Met Trp Gly Val Asn His Ser 
        35                  40                  45              


Ile Asn Glu Leu Ser His Val Gln Ile Pro Val Met Leu Met Pro Asp 
    50                  55                  60                  


Asp Phe Lys Ala Tyr Ser Lys Ile Lys Val Asp Asn His Leu Phe Asn 
65                  70                  75                  80  


Lys Glu Asn Met Pro Ser His Phe Lys Phe Lys Glu Tyr Cys Pro Met 
                85                  90                  95      


Val Phe Arg Asn Leu Arg Glu Arg Phe Gly Ile Asp Asp Gln Asp Phe 
            100                 105                 110         


Gln Asn Ser Leu Thr Arg Ser Ala Pro Leu Pro Asn Asp Ser Gln Ala 
        115                 120                 125             


Arg Ser Gly Ala Arg Phe His Thr Ser Tyr Asp Lys Arg Tyr Ile Ile 
    130                 135                 140                 


Lys Thr Ile Thr Ser Glu Asp Val Ala Glu Met His Asn Ile Leu Lys 
145                 150                 155                 160 


Lys Tyr His Gln Tyr Ile Val Glu Cys His Gly Ile Thr Leu Leu Pro 
                165                 170                 175     


Gln Phe Leu Gly Met Tyr Arg Leu Asn Val Asp Gly Val Glu Ile Tyr 
            180                 185                 190         


Val Ile Val Thr Arg Asn Val Phe Ser His Arg Leu Ser Val Tyr Arg 
        195                 200                 205             


Lys Tyr Asp Leu Lys Gly Ser Thr Val Ala Arg Glu Ala Ser Asp Lys 
    210                 215                 220                 


Glu Lys Ala Lys Glu Leu Pro Thr Leu Lys Asp Asn Asp Phe Ile Asn 
225                 230                 235                 240 


Glu Gly Gln Lys Ile Tyr Ile Asp Asp Asn Asn Lys Lys Val Phe Leu 
                245                 250                 255     


Glu Lys Leu Lys Lys Asp Val Glu Phe Leu Ala Gln Leu Lys Leu Met 
            260                 265                 270         


Asp Tyr Ser Leu Leu Val Gly Ile His Asp Val Glu Arg Ala Glu Gln 
        275                 280                 285             


Glu Glu Val Glu Cys Glu Glu Asn Asp Gly Glu Glu Glu Gly Glu Ser 
    290                 295                 300                 


Asp Gly Thr His Pro Val Gly Thr Pro Pro Asp Ser Pro Gly Asn Thr 
305                 310                 315                 320 


Leu Asn Ser Ser Pro Pro Leu Ala Pro Gly Glu Phe Asp Pro Asn Ile 
                325                 330                 335     


Asp Val Tyr Gly Ile Lys Cys His Glu Asn Ser Pro Arg Lys Glu Val 
            340                 345                 350         


Tyr Phe Met Ala Ile Ile Asp Ile Leu Thr His Tyr Asp Ala Lys Lys 
        355                 360                 365             


Lys Ala Ala His Ala Ala Lys Thr Val Lys His Gly Ala Gly Ala Glu 
    370                 375                 380                 


Ile Ser Thr Val Asn Pro Glu Gln Tyr Ser Lys Arg Phe Leu Asp Phe 
385                 390                 395                 400 


Ile Gly His Ile Leu Thr 
                405     


<210>  21
<211>  3628
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (207)..(1250)

<400>  21
gcagctgctg cggggcgggg agccggagtc agccctggac ctccggctgc tcgcccgcct       60

cgaagccccc agccccgcgg cgcgtgcccc cagccctctg ggccgcccag gcaccaccac      120

ttgcgtcccc tttagatcta tggcccggtg cgggtcgggg gtcccgtgtg catatcaatg      180

aactgagcca tgttcaaatc cctgtt atg ttg atg cca gat gac ttc aaa gcc       233
                             Met Leu Met Pro Asp Asp Phe Lys Ala          
                             1               5                            

tat tca aaa ata aag gtg gac aat cac ctt ttt aac aaa gaa aac atg        281
Tyr Ser Lys Ile Lys Val Asp Asn His Leu Phe Asn Lys Glu Asn Met           
10                  15                  20                  25            

ccg agc cat ttc aag ttt aag gaa tac tgc ccg atg gtc ttc cgt aac        329
Pro Ser His Phe Lys Phe Lys Glu Tyr Cys Pro Met Val Phe Arg Asn           
                30                  35                  40                

ctg cgg gag agg ttt gga att gat gat caa gat ttc cag aat tcc ctg        377
Leu Arg Glu Arg Phe Gly Ile Asp Asp Gln Asp Phe Gln Asn Ser Leu           
            45                  50                  55                    

acc agg agc gca ccc ctc ccc aac gac tcc cag gcc cgc agt gga gct        425
Thr Arg Ser Ala Pro Leu Pro Asn Asp Ser Gln Ala Arg Ser Gly Ala           
        60                  65                  70                        

cgt ttt cac act tcc tac gac aaa aga tac atc atc aag act att acc        473
Arg Phe His Thr Ser Tyr Asp Lys Arg Tyr Ile Ile Lys Thr Ile Thr           
    75                  80                  85                            

agt gaa gac gtg gcc gaa atg cac aac atc ctg aag aaa tac cac cag        521
Ser Glu Asp Val Ala Glu Met His Asn Ile Leu Lys Lys Tyr His Gln           
90                  95                  100                 105           

tac ata gtg gaa tgt cat ggg atc acc ctt ctt ccc cag ttc ttg ggc        569
Tyr Ile Val Glu Cys His Gly Ile Thr Leu Leu Pro Gln Phe Leu Gly           
                110                 115                 120               

atg tac cgg ctt aat gtt gat gga gtt gaa ata tat gtg ata gtt aca        617
Met Tyr Arg Leu Asn Val Asp Gly Val Glu Ile Tyr Val Ile Val Thr           
            125                 130                 135                   

aga aat gta ttc agc cac cgt ttg tct gtg tat agg aaa tac gac tta        665
Arg Asn Val Phe Ser His Arg Leu Ser Val Tyr Arg Lys Tyr Asp Leu           
        140                 145                 150                       

aag ggc tct aca gtg gct aga gaa gct agt gac aaa gaa aag gcc aaa        713
Lys Gly Ser Thr Val Ala Arg Glu Ala Ser Asp Lys Glu Lys Ala Lys           
    155                 160                 165                           

gaa ctg cca act ctg aaa gat aat gat ttc att aat gag ggc caa aag        761
Glu Leu Pro Thr Leu Lys Asp Asn Asp Phe Ile Asn Glu Gly Gln Lys           
170                 175                 180                 185           

att tat att gat gac aac aac aag aag gtc ttc ctg gaa aaa cta aaa        809
Ile Tyr Ile Asp Asp Asn Asn Lys Lys Val Phe Leu Glu Lys Leu Lys           
                190                 195                 200               

aag gat gtt gag ttt ctg gcc cag ctg aag ctc atg gac tac agt ctg        857
Lys Asp Val Glu Phe Leu Ala Gln Leu Lys Leu Met Asp Tyr Ser Leu           
            205                 210                 215                   

ctg gtg gga att cat gat gtg gag aga gcc gaa cag gag gaa gtg gag        905
Leu Val Gly Ile His Asp Val Glu Arg Ala Glu Gln Glu Glu Val Glu           
        220                 225                 230                       

tgt gag gag aac gat ggg gag gag gag ggc gag agc gat ggc acc cac        953
Cys Glu Glu Asn Asp Gly Glu Glu Glu Gly Glu Ser Asp Gly Thr His           
    235                 240                 245                           

ccg gtg gga acc ccc cca gat agc ccc ggg aat aca ctg aac agc tca       1001
Pro Val Gly Thr Pro Pro Asp Ser Pro Gly Asn Thr Leu Asn Ser Ser           
250                 255                 260                 265           

cca ccc ctg gct ccc ggg gag ttc gat ccg aac atc gac gtc tat gga       1049
Pro Pro Leu Ala Pro Gly Glu Phe Asp Pro Asn Ile Asp Val Tyr Gly           
                270                 275                 280               

att aag tgc cat gaa aac tcg cct agg aag gag gtg tac ttc atg gca       1097
Ile Lys Cys His Glu Asn Ser Pro Arg Lys Glu Val Tyr Phe Met Ala           
            285                 290                 295                   

att att gac atc ctt act cat tat gat gca aaa aag aaa gct gcc cat       1145
Ile Ile Asp Ile Leu Thr His Tyr Asp Ala Lys Lys Lys Ala Ala His           
        300                 305                 310                       

gct gca aaa act gtt aaa cat ggc gct ggc gcg gag atc tcc acc gtg       1193
Ala Ala Lys Thr Val Lys His Gly Ala Gly Ala Glu Ile Ser Thr Val           
    315                 320                 325                           

aac cca gaa cag tat tca aag cgc ttt ttg gac ttt att ggc cac atc       1241
Asn Pro Glu Gln Tyr Ser Lys Arg Phe Leu Asp Phe Ile Gly His Ile           
330                 335                 340                 345           

ttg acg taa cctcctgcgc agcctcggac agacatgaac attggatgga               1290
Leu Thr                                                                   
                                                                          

cagaggtggc ttcggtgtag gaaaaatgaa aaccaaactc agtgaagtac tcatcttgca     1350

ggaagcaaac ctccttgttt acatcttcag gccaagatga ctgatttggg ggctactcgc     1410

tttacagcta cctgattttc ccagcatcgt tctagctatt tctgactttg tgtatatgtg     1470

tgtgtgtgtg tgttgggggg gggtgagtgt gtgcgcgcgt gtgcatttta aaagtcataa     1530

attaattaaa acagatccac ttcggtcagt atgtgtccca acaaagaccc tttgattcca     1590

gctatggccg aatgaatgag tgagtgagtg agtgagtgaa tgaacacacg tgtgggggag     1650

gggagaagga agtgcatgat gtcaggcacc gtgttggcat cacacaacaa actgtggatc     1710

agtttttttt tttttttttt ttttttggag ttgaaagatg tgagacagta ttcagaataa     1770

tgaagataat aatgatgatt attataataa tgatgatgat tccaaggaaa aaacctacag     1830

cgaatgttcc atttctaccc cgcacgcaga cactctccct aacactgata acctgagccc     1890

ccagcactgg acggaagaat gctggcgtct ccgtgtgtac tggttcaggg ttctggcccc     1950

agccttgtca ggaccccctg gtgtccagag cccccacccc tcccgcaaca agcagctgat     2010

gccccagtga ttctctatac atttttcacc tcggccaata tgtccaggaa aactgcttac     2070

ttctcttttc ttgcctggag ccttcattgt tcacccttac gttgcaatat aggaattaat     2130

gctacaaaat aaaagtaaag cttacctgaa aagtgcatag tttggggcaa tggtatctac     2190

atctcccact gtgggaaaac cagcaaagca tcaaaactct caattctcct gttaccaaat     2250

gcagatctga attataagat gtttatgttt gaccattgtt tcaacaatgg gattttgtta     2310

cgaattatcc ctttaactga aaccctcagt tttactgttt acattattag gaaaacaggg     2370

atatcttttg aatctaaaaa tttgatgtac agcatgtgat ttttgaagtt tacatgtaaa     2430

gtcacagtat aggtgaaata acgtttgtca tattttgaga cgtatcctgc agccatgttt     2490

ttacgtgagt gttttagtca aagtacatgg tagacagtct ttcacaataa aaggaaaagg     2550

attttttttt cctccaaatg tacatttatc aacctaatga ttgatttttt taaaaagaga     2610

tttcgcccca gtctggttta tgaaagttca ttgccctaaa ctgtgctgat tgtttttaat     2670

caagttataa atttccaacc tagatcatgt atctaccaac tctcctgcat tttccaaaag     2730

gcattgagct taaatattag tcttgcttag agtaggttat ccacttacat gctgcgctaa     2790

agccatgcct ttgaaactcc ttgtttaaaa catgatatga tttttgtggg cagtttcaga     2850

aaagaaaaca aacaaacaaa aatcgaccct ttaattatta cttgcaactc aacagatctc     2910

cctgccgtac tgccttttcc aggaacttta cttcagggct gtccagattg cagctgtgcc     2970

ccgtgtatgt ggatctagtt cacagagtct ttggaagcca gcagtcgtgc cctccgtata     3030

ctgtccactc attttatgta gatttggtat cctcagcagc cagtgttaac accactgtca     3090

cgtagtgtac agattcatct tttatgtatt taaagtaatc catactatga tttggttttt     3150

ccctgcacca ttaattctgg catcagatca gtttttgtgt tgtgaagttc tactgtggtt     3210

tgacccaaga ccacaaccat gagaccctga agtaaagata aggtacacat acattatttg     3270

agtaactgtt tccttggggg ccaatctgtg tatgctttta gaagtttaca gaatgctttt     3330

atttttgtct ataacaaaca gtctgtcatt tatttctgtt gataaaccat ttggacagag     3390

tgaggacgtt tgccctgtta tctcctagtg ctaacaatac actccagtca tgagccgggc     3450

tttacaaata aagcactttt gatgactcac aagatgaatc cttttttcct ctgtcccaat     3510

tgtgtgtctc tgttccaaac acattttaaa tactcggtcc tgacagtgtc tttagctaat     3570

ccttgaagaa atgaaagtgg aattgaatct ttttagtttc tagaaaaaaa aaaaaaaa       3628


<210>  22
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Leu Met Pro Asp Asp Phe Lys Ala Tyr Ser Lys Ile Lys Val Asp 
1               5                   10                  15      


Asn His Leu Phe Asn Lys Glu Asn Met Pro Ser His Phe Lys Phe Lys 
            20                  25                  30          


Glu Tyr Cys Pro Met Val Phe Arg Asn Leu Arg Glu Arg Phe Gly Ile 
        35                  40                  45              


Asp Asp Gln Asp Phe Gln Asn Ser Leu Thr Arg Ser Ala Pro Leu Pro 
    50                  55                  60                  


Asn Asp Ser Gln Ala Arg Ser Gly Ala Arg Phe His Thr Ser Tyr Asp 
65                  70                  75                  80  


Lys Arg Tyr Ile Ile Lys Thr Ile Thr Ser Glu Asp Val Ala Glu Met 
                85                  90                  95      


His Asn Ile Leu Lys Lys Tyr His Gln Tyr Ile Val Glu Cys His Gly 
            100                 105                 110         


Ile Thr Leu Leu Pro Gln Phe Leu Gly Met Tyr Arg Leu Asn Val Asp 
        115                 120                 125             


Gly Val Glu Ile Tyr Val Ile Val Thr Arg Asn Val Phe Ser His Arg 
    130                 135                 140                 


Leu Ser Val Tyr Arg Lys Tyr Asp Leu Lys Gly Ser Thr Val Ala Arg 
145                 150                 155                 160 


Glu Ala Ser Asp Lys Glu Lys Ala Lys Glu Leu Pro Thr Leu Lys Asp 
                165                 170                 175     


Asn Asp Phe Ile Asn Glu Gly Gln Lys Ile Tyr Ile Asp Asp Asn Asn 
            180                 185                 190         


Lys Lys Val Phe Leu Glu Lys Leu Lys Lys Asp Val Glu Phe Leu Ala 
        195                 200                 205             


Gln Leu Lys Leu Met Asp Tyr Ser Leu Leu Val Gly Ile His Asp Val 
    210                 215                 220                 


Glu Arg Ala Glu Gln Glu Glu Val Glu Cys Glu Glu Asn Asp Gly Glu 
225                 230                 235                 240 


Glu Glu Gly Glu Ser Asp Gly Thr His Pro Val Gly Thr Pro Pro Asp 
                245                 250                 255     


Ser Pro Gly Asn Thr Leu Asn Ser Ser Pro Pro Leu Ala Pro Gly Glu 
            260                 265                 270         


Phe Asp Pro Asn Ile Asp Val Tyr Gly Ile Lys Cys His Glu Asn Ser 
        275                 280                 285             


Pro Arg Lys Glu Val Tyr Phe Met Ala Ile Ile Asp Ile Leu Thr His 
    290                 295                 300                 


Tyr Asp Ala Lys Lys Lys Ala Ala His Ala Ala Lys Thr Val Lys His 
305                 310                 315                 320 


Gly Ala Gly Ala Glu Ile Ser Thr Val Asn Pro Glu Gln Tyr Ser Lys 
                325                 330                 335     


Arg Phe Leu Asp Phe Ile Gly His Ile Leu Thr 
            340                 345         


<210>  23
<211>  5732
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (482)..(1732)

<400>  23
ttgcgggaaa gagccaaacc ctggcgttgg ggggcccggg cggggagccc ctcccgcggt       60

ccacagcgac gcctgcccag ccctcctccc cttccggctc cggcacgggg ccccgaggcg      120

ttcggaggcc aggcgggttt ctgtcaggcc cggggaggag gggcgggcgg ggcggccgct      180

gcctccccgg gacgggccgt accacgcgga cggggaggac ggggccaggg gactgcaggg      240

cggctgcacc gcccgggggc ggggtgcgga gcgggccggc gggctccccg gggcggggcg      300

ggagggcggg gcgtggggcg gacggaacca ccggggcggg gtgggaggta acgggacggg      360

cgcgaccatg gcgcggtgag ggagcggggg tggggatcgg tccgggggag gcctgaggcc      420

gctggcttgt gcgctgtctc cgccgccccc ctctttcgcc gccgccgccg ccgccccggg      480

c atg tcg tcc aac tgc acc agc acc acg gcg gtg gcg gtg gcg ccg ctc      529
  Met Ser Ser Asn Cys Thr Ser Thr Thr Ala Val Ala Val Ala Pro Leu         
  1               5                   10                  15              

agc gcc agc aag acc aag acc aag aag aag cat ttc gtg tgc cag aaa        577
Ser Ala Ser Lys Thr Lys Thr Lys Lys Lys His Phe Val Cys Gln Lys           
            20                  25                  30                    

gtg aag cta ttc cgg gcc agc gag ccg atc ctc agc gtc ctg atg tgg        625
Val Lys Leu Phe Arg Ala Ser Glu Pro Ile Leu Ser Val Leu Met Trp           
        35                  40                  45                        

ggg gtg aac cac acg atc aat gag ctg agc aat gtt cct gtt cct gtc        673
Gly Val Asn His Thr Ile Asn Glu Leu Ser Asn Val Pro Val Pro Val           
    50                  55                  60                            

atg cta atg cca gat gac ttc aaa gcc tac agc aag atc aag gtg gac        721
Met Leu Met Pro Asp Asp Phe Lys Ala Tyr Ser Lys Ile Lys Val Asp           
65                  70                  75                  80            

aat cat ctc ttc aat aag gag aac ctg ccc agc cgc ttt aag ttt aag        769
Asn His Leu Phe Asn Lys Glu Asn Leu Pro Ser Arg Phe Lys Phe Lys           
                85                  90                  95                

gag tat tgc ccc atg gtg ttc cga aac ctt cgg gag agg ttt gga att        817
Glu Tyr Cys Pro Met Val Phe Arg Asn Leu Arg Glu Arg Phe Gly Ile           
            100                 105                 110                   

gat gat cag gat tac cag aat tca gtg acg cgc agc gcc ccc atc aac        865
Asp Asp Gln Asp Tyr Gln Asn Ser Val Thr Arg Ser Ala Pro Ile Asn           
        115                 120                 125                       

agt gac agc cag ggt cgg tgt ggc acg cgt ttc ctc acc acc tac gac        913
Ser Asp Ser Gln Gly Arg Cys Gly Thr Arg Phe Leu Thr Thr Tyr Asp           
    130                 135                 140                           

cgg cgc ttt gtc atc aag act gtg tcc agc gag gac gtg gcg gag atg        961
Arg Arg Phe Val Ile Lys Thr Val Ser Ser Glu Asp Val Ala Glu Met           
145                 150                 155                 160           

cac aac atc tta aag aaa tac cac cag ttt ata gtg gag tgt cat ggc       1009
His Asn Ile Leu Lys Lys Tyr His Gln Phe Ile Val Glu Cys His Gly           
                165                 170                 175               

aac acg ctt ttg cca cag ttc ctg ggc atg tac cgc ctg acc gtg gat       1057
Asn Thr Leu Leu Pro Gln Phe Leu Gly Met Tyr Arg Leu Thr Val Asp           
            180                 185                 190                   

ggt gtg gaa acc tac atg gtg gtt acc agg aac gtg ttc agc cat cgg       1105
Gly Val Glu Thr Tyr Met Val Val Thr Arg Asn Val Phe Ser His Arg           
        195                 200                 205                       

ctc act gtg cat cgc aag tat gac ctc aag ggt tct acg gtt gcc aga       1153
Leu Thr Val His Arg Lys Tyr Asp Leu Lys Gly Ser Thr Val Ala Arg           
    210                 215                 220                           

gaa gcg agc gac aag gag aag gcc aag gac ttg cca aca ttc aaa gac       1201
Glu Ala Ser Asp Lys Glu Lys Ala Lys Asp Leu Pro Thr Phe Lys Asp           
225                 230                 235                 240           

aat gac ttc ctc aat gaa ggg cag aag ctg cat gtg gga gag gag agt       1249
Asn Asp Phe Leu Asn Glu Gly Gln Lys Leu His Val Gly Glu Glu Ser           
                245                 250                 255               

aaa aag aac ttc ctg gag aaa ctg aag cgg gac gtt gag ttc ttg gca       1297
Lys Lys Asn Phe Leu Glu Lys Leu Lys Arg Asp Val Glu Phe Leu Ala           
            260                 265                 270                   

cag ctg aag atc atg gac tac agc ctg ctg gtg ggc atc cac gac gtg       1345
Gln Leu Lys Ile Met Asp Tyr Ser Leu Leu Val Gly Ile His Asp Val           
        275                 280                 285                       

gac cgg gca gag cag gag gag atg gag gtg gag gag cgg gca gag gac       1393
Asp Arg Ala Glu Gln Glu Glu Met Glu Val Glu Glu Arg Ala Glu Asp           
    290                 295                 300                           

gag gag tgt gag aat gat ggg gtg ggt ggc aac cta ctc tgc tcc tat       1441
Glu Glu Cys Glu Asn Asp Gly Val Gly Gly Asn Leu Leu Cys Ser Tyr           
305                 310                 315                 320           

ggc aca cct ccg gac agc cct ggc aac ctc ctc agc ttt cct cgg ttc       1489
Gly Thr Pro Pro Asp Ser Pro Gly Asn Leu Leu Ser Phe Pro Arg Phe           
                325                 330                 335               

ttt ggt cct ggg gaa ttc gac ccc tct gtt gac gtc tat gcc atg aaa       1537
Phe Gly Pro Gly Glu Phe Asp Pro Ser Val Asp Val Tyr Ala Met Lys           
            340                 345                 350                   

agc cat gaa agt tcc ccc aag aag gag gtg tat ttc atg gcc atc att       1585
Ser His Glu Ser Ser Pro Lys Lys Glu Val Tyr Phe Met Ala Ile Ile           
        355                 360                 365                       

gat atc ctc acg cca tac gat aca aag aag aaa gct gca cat gct gcc       1633
Asp Ile Leu Thr Pro Tyr Asp Thr Lys Lys Lys Ala Ala His Ala Ala           
    370                 375                 380                           

aaa acg gtg aaa cac ggg gca ggg gcc gag atc tcg act gtg aac cct       1681
Lys Thr Val Lys His Gly Ala Gly Ala Glu Ile Ser Thr Val Asn Pro           
385                 390                 395                 400           

gag cag tac tcc aaa cgc ttc aac gag ttt atg tcc aac atc ctg acg       1729
Glu Gln Tyr Ser Lys Arg Phe Asn Glu Phe Met Ser Asn Ile Leu Thr           
                405                 410                 415               

tag ttctcttcta ccttcagcca gagccagaga gctggatatg gggtcgggga            1782

tcgggagtta gggagaaggg tgtatttggg ctagatggga gggtgggagc agagtcgggt     1842

ttgggagggc tttagcaatg agactgcagc ctgtgacacc gaaagagact ttagctgaag     1902

aggaggggga tgtgctgtgt gtgcacctgc tcacaggatg taaccccacc ttctgcttac     1962

ccttgatttt ttctccccat ttgacaccca ggttaaaaag gggttccctt tttggtacct     2022

tgtaaccttt taagatacct tggggctaga gatgacttcg tgggtttatt tgggttttgt     2082

ttctgaaatt tcattgctcc aggtttgcta tttataatca tatttcatca gcctacccac     2142

cctccccatc tttgctgagc tctcagttcc cttcaattaa agagataccc ggtagaccca     2202

gcacaagggt ccttccagaa ccaagtgcta tggatgccag attggagagg tcagacacct     2262

cgccctgctg catttgctct tgtctggatt aactttgtaa tttatggagt attgtgcaca     2322

acttcctcca cctttccctt ggattcaagt gaaaactgtt gcattattcc tccatcctgt     2382

ctggaataca ccaggtcaac accagagatc tcagatcaga atcagagatc tcagagggga     2442

ataagttcat cctcatggga tggtgagggg caggaaagcg gctgggctct tggacacctg     2502

gttctcagag aaccctgtga tgatcaccca agccccaggc tgtcttagcc cctggagttc     2562

agaagtcctc tctgtaaagc ctgcctccca ctaggtcaag aggaactaga gtacctttgg     2622

atttatcagg accctcatgt ttaaatggtt atttcccttt gggaaaactt cagaaactga     2682

tgtatcaaat gaggccctgt gccctcgatc tatttccttc ttccttctga cctcctccca     2742

ggcactctta cttctagccg aactcttagc tctgggcaga tctccaagcg cctggagtgc     2802

tttttagcag agacacctcg ttaagctccg ggatgacctt gtaggagatc tgtctccctg     2862

tgcctggaga gttacagcca gcaaggtgcc cccatcttag agtgtggtgt ccaaacgtga     2922

ggtggcttcc tagttacatg aggatgtgat ccaggaaatc cagtttggag gcttgatgtg     2982

ggttttgacc tggcctcagc cttggggctg tttttccttg ttgccccgct ctagactttt     3042

agcagatctg cagcccacag gcttttttgg aaggagtggc ttcctgcagg tgttccacct     3102

gccttcggag cctgccaccc aggccctcag aactgagcca caggctgctc tggccaggag     3162

agaaacagct ctgttgttct gcattggggg aggtacattc ctgcatcttc tcaccccctc     3222

aaccaggaac tggggatttg ggatgagata tggtcagact tgtagataac cccaaagatg     3282

tgaagatcgc ttgtgaaacc attttgaatg aatagattgg tttcctgtgg ctccctccaa     3342

acctggccaa gcccagcttc cgaagcagga accagcactg tctctgtgcc tgactcacag     3402

catataggtc aggaaagaat ggagacggca ttcttggact tcactggggc tgctggattg     3462

gatgggaaac cttctggaag aggcagatgg gggtcaaacc actgccttgg ccccaggaag     3522

gggccatagg taggtctgaa caactgccgc aagaccacta catgacttag ggaacttgaa     3582

accaactggc tcatggagaa aacaaatttg acttgggaaa gggattatgt aggaataatg     3642

tttggacttg atttccccac gtcataatga agaatggaag tttggatctg ctcctcgtca     3702

ggcgcagcat ctctgaagct tggaaagctg tcttccagca gcctccgtgg cctcgggttc     3762

ctaccggctt ctctgcattt ggtctgctga tcatgttgcc ataatgtgta tggaaagtgt     3822

aacacattct tactggttaa agacgactac caggtatcta acttgtttaa cattgagttt     3882

gtgtgtgtgt gtgtatgttt gtgtgttttg tatattgttt acattttgag aggtagcatt     3942

ctgtttcaaa tgctttttgt ttttctgaca gtattgttga ctgggtcata acattttgag     4002

ctgtggtttg gtggattttc aatttttttt tttaaaggtc attcgctgtg ctatcttcaa     4062

aaccttgagt ttggccccca atttttggca ttcaaatgtt taaaagctat ttatcttggt     4122

ttatacaagt ttcctttctc ttctttttgt catggtattc tatttggtct gcagtttgaa     4182

tgtagagaaa gtggactgat cccccaagcg ttgtctgccc ccactctttc ctccttgggt     4242

cccgccattc ttttactggg cagtcgaggg cattggaggg gaagtgactg ccctcagcct     4302

cactccctgg ggccatgaag aaaagctaaa cagtctcatg gcatctcaga ataatgttgg     4362

gtctcccaag aagaaaggtg taagaataac gacatggctg attaggcgag gccaggatag     4422

ggctaaggcc aggattcctg gctggcatcc agtcacccct tctcccatcc ttccccctct     4482

tcttccacaa gtccgcagcc gagacactgt agtctcccag ccacagtgat gagtgccctg     4542

gagactccac tgacctctag atgaaggccc ctggccctgg ttcctgttaa ttaacctctg     4602

ggtctttgag tcccccagca caaacttctt tcctgtaccc tgcggcttgg ggtcacaggg     4662

catgccggga agccacagct gaggggcgca gactgaagca gtgctccacc tctccttctt     4722

tagctcaggg gttgctggtc tgtggcaggc gccacgagtg gcccctgtgg ctgttctcag     4782

tggcagtctc ttaagttccc accacaggca gctctttatc ccctctccct acttgactct     4842

ttctcttgcc tgtgcttttg gcctcaaaca ggcctgctgg tagcgctcag ggcgtgaggc     4902

tacactcctg ccctgccttt cctgtcttca tggtctgcca gggcatacct tggggaggtg     4962

gaccaaagac ccaggacttt ttgcagtagc cagtcctacc ccccagttgt ctttttacca     5022

attcagggtg ggagagaaaa ctgcagcacc ccagcatgtg agttactcag gtgttggggg     5082

ctagaaggga cagtgcgttt aaacaacact cagagctctg gccttaaacc tgtggccccc     5142

caagtctagg agcctcatct cttcctggca gtcatgcggg caggaggtcc tgaaagggaa     5202

aacccattca gacaactgtt ccccaatcta ccagccatct gcaggggtca gtgaccgtgg     5262

ccctctccct cctctagaat gtgccactta tgaagagtgc cccatgggga aaaggagact     5322

cagctgtccc ttggcagctt gtgccagtat cccagggcag aagtttccac aggagcctct     5382

tgcccttgcg cagagccact gtgagaggcg gtgggagcca acacccttgg gggagggggc     5442

agtactgctc ggcacatccc agcatcaggt cagatcattg aaattaaaaa atgtgaatta     5502

agttcatatc caccttttgg ggaagcagga caaaccacca ccccaccaag tgtgtgactt     5562

ctccatatcc cactgcagtt tccatttttt aaatgggaat tttcaatccc ctgtgcttgt     5622

ctaacgtctg ctttaaaaag tttgagaccc tgttactgtt tgaaaatgca tgcatgttac     5682

gatgaatctc caacctgagg aaaaaaataa aactcaaaaa gctttgtgta                5732


<210>  24
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ser Ser Asn Cys Thr Ser Thr Thr Ala Val Ala Val Ala Pro Leu 
1               5                   10                  15      


Ser Ala Ser Lys Thr Lys Thr Lys Lys Lys His Phe Val Cys Gln Lys 
            20                  25                  30          


Val Lys Leu Phe Arg Ala Ser Glu Pro Ile Leu Ser Val Leu Met Trp 
        35                  40                  45              


Gly Val Asn His Thr Ile Asn Glu Leu Ser Asn Val Pro Val Pro Val 
    50                  55                  60                  


Met Leu Met Pro Asp Asp Phe Lys Ala Tyr Ser Lys Ile Lys Val Asp 
65                  70                  75                  80  


Asn His Leu Phe Asn Lys Glu Asn Leu Pro Ser Arg Phe Lys Phe Lys 
                85                  90                  95      


Glu Tyr Cys Pro Met Val Phe Arg Asn Leu Arg Glu Arg Phe Gly Ile 
            100                 105                 110         


Asp Asp Gln Asp Tyr Gln Asn Ser Val Thr Arg Ser Ala Pro Ile Asn 
        115                 120                 125             


Ser Asp Ser Gln Gly Arg Cys Gly Thr Arg Phe Leu Thr Thr Tyr Asp 
    130                 135                 140                 


Arg Arg Phe Val Ile Lys Thr Val Ser Ser Glu Asp Val Ala Glu Met 
145                 150                 155                 160 


His Asn Ile Leu Lys Lys Tyr His Gln Phe Ile Val Glu Cys His Gly 
                165                 170                 175     


Asn Thr Leu Leu Pro Gln Phe Leu Gly Met Tyr Arg Leu Thr Val Asp 
            180                 185                 190         


Gly Val Glu Thr Tyr Met Val Val Thr Arg Asn Val Phe Ser His Arg 
        195                 200                 205             


Leu Thr Val His Arg Lys Tyr Asp Leu Lys Gly Ser Thr Val Ala Arg 
    210                 215                 220                 


Glu Ala Ser Asp Lys Glu Lys Ala Lys Asp Leu Pro Thr Phe Lys Asp 
225                 230                 235                 240 


Asn Asp Phe Leu Asn Glu Gly Gln Lys Leu His Val Gly Glu Glu Ser 
                245                 250                 255     


Lys Lys Asn Phe Leu Glu Lys Leu Lys Arg Asp Val Glu Phe Leu Ala 
            260                 265                 270         


Gln Leu Lys Ile Met Asp Tyr Ser Leu Leu Val Gly Ile His Asp Val 
        275                 280                 285             


Asp Arg Ala Glu Gln Glu Glu Met Glu Val Glu Glu Arg Ala Glu Asp 
    290                 295                 300                 


Glu Glu Cys Glu Asn Asp Gly Val Gly Gly Asn Leu Leu Cys Ser Tyr 
305                 310                 315                 320 


Gly Thr Pro Pro Asp Ser Pro Gly Asn Leu Leu Ser Phe Pro Arg Phe 
                325                 330                 335     


Phe Gly Pro Gly Glu Phe Asp Pro Ser Val Asp Val Tyr Ala Met Lys 
            340                 345                 350         


Ser His Glu Ser Ser Pro Lys Lys Glu Val Tyr Phe Met Ala Ile Ile 
        355                 360                 365             


Asp Ile Leu Thr Pro Tyr Asp Thr Lys Lys Lys Ala Ala His Ala Ala 
    370                 375                 380                 


Lys Thr Val Lys His Gly Ala Gly Ala Glu Ile Ser Thr Val Asn Pro 
385                 390                 395                 400 


Glu Gln Tyr Ser Lys Arg Phe Asn Glu Phe Met Ser Asn Ile Leu Thr 
                405                 410                 415     


<210>  25
<211>  3229
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (132)..(1397)

<400>  25
tcgccctgtt cgcgcgtccg ctgtccggcc tccggtcacg tgacagcagc gcaggtgagc       60

gccgcttccg gggtcgggcg cctggatagc tgccggctcc ggcttccact tggtcggttg      120

cgcgggagac t atg gcg tcc tcc tcg gtc cca cca gcc acg gta tcg gcg       170
             Met Ala Ser Ser Ser Val Pro Pro Ala Thr Val Ser Ala          
             1               5                   10                       

gcg aca gca ggc ccc ggc cca ggt ttc ggc ttc gcc tcc aag acc aag        218
Ala Thr Ala Gly Pro Gly Pro Gly Phe Gly Phe Ala Ser Lys Thr Lys           
    15                  20                  25                            

aag aag cat ttc gtg cag cag aag gtg aag gtg ttc cgg gcg gcc gac        266
Lys Lys His Phe Val Gln Gln Lys Val Lys Val Phe Arg Ala Ala Asp           
30                  35                  40                  45            

ccg ctg gtg ggt gtg ttc ctg tgg ggc gta gcc cac tcg atc aat gag        314
Pro Leu Val Gly Val Phe Leu Trp Gly Val Ala His Ser Ile Asn Glu           
                50                  55                  60                

ctc agc cag gtg cct ccc ccg gtg atg ctg ctg cca gat gac ttt aag        362
Leu Ser Gln Val Pro Pro Pro Val Met Leu Leu Pro Asp Asp Phe Lys           
            65                  70                  75                    

gcc agc tcc aag atc aag gtc aac aat cac ctt ttc cac agg gaa aat        410
Ala Ser Ser Lys Ile Lys Val Asn Asn His Leu Phe His Arg Glu Asn           
        80                  85                  90                        

ctg ccc agt cat ttc aag ttc aag gag tat tgt ccc cag gtc ttc agg        458
Leu Pro Ser His Phe Lys Phe Lys Glu Tyr Cys Pro Gln Val Phe Arg           
    95                  100                 105                           

aac ctc cgt gat cga ttt ggc att gat gac caa gat tac ttg gtg tcc        506
Asn Leu Arg Asp Arg Phe Gly Ile Asp Asp Gln Asp Tyr Leu Val Ser           
110                 115                 120                 125           

ctt acc cga aac ccc ccc agc gaa agt gaa ggc agt gat ggt cgc ttc        554
Leu Thr Arg Asn Pro Pro Ser Glu Ser Glu Gly Ser Asp Gly Arg Phe           
                130                 135                 140               

ctt atc tcc tac gat cgg act ctg gtc atc aaa gaa gta tcc agt gag        602
Leu Ile Ser Tyr Asp Arg Thr Leu Val Ile Lys Glu Val Ser Ser Glu           
            145                 150                 155                   

gac att gct gac atg cat agc aac ctc tcc aac tat cac cag tac att        650
Asp Ile Ala Asp Met His Ser Asn Leu Ser Asn Tyr His Gln Tyr Ile           
        160                 165                 170                       

gtg aag tgc cat ggc aac acg ctt ctg ccc cag ttc ctg ggg atg tac        698
Val Lys Cys His Gly Asn Thr Leu Leu Pro Gln Phe Leu Gly Met Tyr           
    175                 180                 185                           

cga gtc agt gtg gac aac gaa gac agc tac atg ctt gtg atg cgc aat        746
Arg Val Ser Val Asp Asn Glu Asp Ser Tyr Met Leu Val Met Arg Asn           
190                 195                 200                 205           

atg ttt agc cac cgt ctt cct gtg cac agg aag tat gac ctc aag ggt        794
Met Phe Ser His Arg Leu Pro Val His Arg Lys Tyr Asp Leu Lys Gly           
                210                 215                 220               

tcc cta gtg tcc cgg gaa gcc agc gat aag gaa aag gtt aaa gaa ttg        842
Ser Leu Val Ser Arg Glu Ala Ser Asp Lys Glu Lys Val Lys Glu Leu           
            225                 230                 235                   

ccc acc ctt aag gat atg gac ttt ctc aac aag aac cag aaa gta tat        890
Pro Thr Leu Lys Asp Met Asp Phe Leu Asn Lys Asn Gln Lys Val Tyr           
        240                 245                 250                       

att ggt gaa gag gag aag aaa ata ttt ctg gag aag ctg aag aga gat        938
Ile Gly Glu Glu Glu Lys Lys Ile Phe Leu Glu Lys Leu Lys Arg Asp           
    255                 260                 265                           

gtg gag ttt cta gtg cag ctg aag atc atg gac tac agc ctt ctg cta        986
Val Glu Phe Leu Val Gln Leu Lys Ile Met Asp Tyr Ser Leu Leu Leu           
270                 275                 280                 285           

ggc atc cac gac atc att cgg ggc tct gaa cca gag gag gaa gcg ccc       1034
Gly Ile His Asp Ile Ile Arg Gly Ser Glu Pro Glu Glu Glu Ala Pro           
                290                 295                 300               

gtg cgg gag gat gag tca gag gtg gat ggg gac tgc agc ctg act gga       1082
Val Arg Glu Asp Glu Ser Glu Val Asp Gly Asp Cys Ser Leu Thr Gly           
            305                 310                 315                   

cct cct gct ctg gtg ggc tcc tat ggc acc tcc cca gag ggt atc gga       1130
Pro Pro Ala Leu Val Gly Ser Tyr Gly Thr Ser Pro Glu Gly Ile Gly           
        320                 325                 330                       

ggc tac atc cat tcc cat cgg ccc ctg ggc cca gga gag ttt gag tcc       1178
Gly Tyr Ile His Ser His Arg Pro Leu Gly Pro Gly Glu Phe Glu Ser           
    335                 340                 345                           

ttc att gat gtc tat gcc atc cgg agt gct gaa gga gcc ccc cag aag       1226
Phe Ile Asp Val Tyr Ala Ile Arg Ser Ala Glu Gly Ala Pro Gln Lys           
350                 355                 360                 365           

gag gtc tac ttc atg ggc ctc att gat atc ctt aca cag tat gat gcc       1274
Glu Val Tyr Phe Met Gly Leu Ile Asp Ile Leu Thr Gln Tyr Asp Ala           
                370                 375                 380               

aag aag aaa gca gct cat gca gcc aaa act gtc aag cat ggg gct ggg       1322
Lys Lys Lys Ala Ala His Ala Ala Lys Thr Val Lys His Gly Ala Gly           
            385                 390                 395                   

gca gag atc tct act gtc cat ccg gag cag tat gct aag cga ttc ctg       1370
Ala Glu Ile Ser Thr Val His Pro Glu Gln Tyr Ala Lys Arg Phe Leu           
        400                 405                 410                       

gat ttt att acc aac atc ttt gcc taa gagactgcct ggttctctct             1417
Asp Phe Ile Thr Asn Ile Phe Ala                                           
    415                 420                                               

gatgttcaag gtggtggggt tctgagacac ttgggggaat tgtggggata ttctagccac     1477

cagttctctt cttcctttgc taaattcagg ctgcaggctc cttccatcca gataactcca     1537

tcctgtcgag taggctcttt ctgaccctca gaaatacatt gtcctttttc ctctttgccc     1597

atttttcttc cctctcttcc tccccatgag aagtctgctt gtagtattag aatgttattg     1657

ttgactctct cccaagtgcc ttgatctttg taatatctcc tgttgtttct atgatatagg     1717

agctagggga agggggttgt ttgccttctt caggacctga ctggacagat ggacctggct     1777

caagcaacta ctctggatgc actttgctgt gtgggatgaa ctaaaagtgt ctgaattttg     1837

ctgataactt tataaaactc actatggcat gcttccctcc tggtgggccc taggatggat     1897

gacactcaag atactacaga tgtgggtgca ggcatgcaca cacacgatgg aatatggcca     1957

ttcctacaca ggtggggtag agagtgggtc agcagcctgg cacctcacag aggtgggacc     2017

taagaggact catgattatg cagagaattg gattgggtct ctgtcataga ttgagtaatc     2077

tcttccctta cctcaattcc atctccaccc atctctacat ctgggcacag caacccagag     2137

atggccaaaa gcattcaagc ctgggggaag atgtttgact attgctgctc ttcaccagaa     2197

cctcacacct ctcctgggac tggaaccctt cagtgggtgt gtggccagtt ttggaggctg     2257

gaatgatggg ccagggtgta ggattcattc tccatgtaaa gtttcctttc atcctgccta     2317

gccatcccca aggtttattt ccagaagaaa ggaatatctc tacttggatc aattctggtc     2377

atttcaagag gatggaggcc tcaagtgtgg gaacttcccc tactccctgg atgtgtgtac     2437

ctagcacact tccttctccc accccttttt ccagttggat ttgtttttct gttctcttct     2497

gtcctgtctt atactgcaac tgtgtctcct aggggacaga tggccttctt tgtcatcttc     2557

actctccacc cccagagagg agtcagagcc ataactcaat cactcagccc ctccaaagat     2617

agttgatgtg tgataatctc ataatgttga gaaccctgat gagatacatt gtcttcctct     2677

ccctacaatg cctctggggc caaggcaccc attcttcttg ctatcctcca tcccccttga     2737

ggcttccact tttttttttt ttagacataa agctgggcat cagcaactgg cctgtggtga     2797

tgcaaagctg ctttgctctg tatctggctg gactgatctg tctcacaaga agccatgagg     2857

ccatagggag aagctccctc tccccttcat cttctgctcc aaaggtggta gcaagaggag     2917

tacccagtta ggggttggag cccccatata acatcttcct gtcagaagac tgatggatct     2977

ttttcattcc aaccatctcc ctttcccccg atgaatgcaa taaaactctg tgacaccagc     3037

aaccattgct ctttagaaat gggttttctg atcatatggc tgatgtgtta tgggcagtat     3097

ggatgtcttc atttgttgct tctgtttttc atcttttttg ttttattaat aaaaatttat     3157

gtatttgctc ctgttactat aataatacag ggaataaatt attcaatcca aatttctgta     3217

caaaaaaaaa aa                                                         3229


<210>  26
<211>  421
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Ser Ser Ser Val Pro Pro Ala Thr Val Ser Ala Ala Thr Ala 
1               5                   10                  15      


Gly Pro Gly Pro Gly Phe Gly Phe Ala Ser Lys Thr Lys Lys Lys His 
            20                  25                  30          


Phe Val Gln Gln Lys Val Lys Val Phe Arg Ala Ala Asp Pro Leu Val 
        35                  40                  45              


Gly Val Phe Leu Trp Gly Val Ala His Ser Ile Asn Glu Leu Ser Gln 
    50                  55                  60                  


Val Pro Pro Pro Val Met Leu Leu Pro Asp Asp Phe Lys Ala Ser Ser 
65                  70                  75                  80  


Lys Ile Lys Val Asn Asn His Leu Phe His Arg Glu Asn Leu Pro Ser 
                85                  90                  95      


His Phe Lys Phe Lys Glu Tyr Cys Pro Gln Val Phe Arg Asn Leu Arg 
            100                 105                 110         


Asp Arg Phe Gly Ile Asp Asp Gln Asp Tyr Leu Val Ser Leu Thr Arg 
        115                 120                 125             


Asn Pro Pro Ser Glu Ser Glu Gly Ser Asp Gly Arg Phe Leu Ile Ser 
    130                 135                 140                 


Tyr Asp Arg Thr Leu Val Ile Lys Glu Val Ser Ser Glu Asp Ile Ala 
145                 150                 155                 160 


Asp Met His Ser Asn Leu Ser Asn Tyr His Gln Tyr Ile Val Lys Cys 
                165                 170                 175     


His Gly Asn Thr Leu Leu Pro Gln Phe Leu Gly Met Tyr Arg Val Ser 
            180                 185                 190         


Val Asp Asn Glu Asp Ser Tyr Met Leu Val Met Arg Asn Met Phe Ser 
        195                 200                 205             


His Arg Leu Pro Val His Arg Lys Tyr Asp Leu Lys Gly Ser Leu Val 
    210                 215                 220                 


Ser Arg Glu Ala Ser Asp Lys Glu Lys Val Lys Glu Leu Pro Thr Leu 
225                 230                 235                 240 


Lys Asp Met Asp Phe Leu Asn Lys Asn Gln Lys Val Tyr Ile Gly Glu 
                245                 250                 255     


Glu Glu Lys Lys Ile Phe Leu Glu Lys Leu Lys Arg Asp Val Glu Phe 
            260                 265                 270         


Leu Val Gln Leu Lys Ile Met Asp Tyr Ser Leu Leu Leu Gly Ile His 
        275                 280                 285             


Asp Ile Ile Arg Gly Ser Glu Pro Glu Glu Glu Ala Pro Val Arg Glu 
    290                 295                 300                 


Asp Glu Ser Glu Val Asp Gly Asp Cys Ser Leu Thr Gly Pro Pro Ala 
305                 310                 315                 320 


Leu Val Gly Ser Tyr Gly Thr Ser Pro Glu Gly Ile Gly Gly Tyr Ile 
                325                 330                 335     


His Ser His Arg Pro Leu Gly Pro Gly Glu Phe Glu Ser Phe Ile Asp 
            340                 345                 350         


Val Tyr Ala Ile Arg Ser Ala Glu Gly Ala Pro Gln Lys Glu Val Tyr 
        355                 360                 365             


Phe Met Gly Leu Ile Asp Ile Leu Thr Gln Tyr Asp Ala Lys Lys Lys 
    370                 375                 380                 


Ala Ala His Ala Ala Lys Thr Val Lys His Gly Ala Gly Ala Glu Ile 
385                 390                 395                 400 


Ser Thr Val His Pro Glu Gln Tyr Ala Lys Arg Phe Leu Asp Phe Ile 
                405                 410                 415     


Thr Asn Ile Phe Ala 
            420     


<210>  27
<211>  2940
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (132)..(1397)

<400>  27
tcgccctgtt cgcgcgtccg ctgtccggcc tccggtcacg tgacagcagc gcaggtgagc       60

gccgcttccg gggtcgggcg cctggatagc tgccggctcc ggcttccact tggtcggttg      120

cgcgggagac t atg gcg tcc tcc tcg gtc cca cca gcc acg gta tcg gcg       170
             Met Ala Ser Ser Ser Val Pro Pro Ala Thr Val Ser Ala          
             1               5                   10                       

gcg aca gca ggc ccc ggc cca ggt ttc ggc ttc gcc tcc aag acc aag        218
Ala Thr Ala Gly Pro Gly Pro Gly Phe Gly Phe Ala Ser Lys Thr Lys           
    15                  20                  25                            

aag aag cat ttc gtg cag cag aag gtg aag gtg ttc cgg gcg gcc gac        266
Lys Lys His Phe Val Gln Gln Lys Val Lys Val Phe Arg Ala Ala Asp           
30                  35                  40                  45            

ccg ctg gtg ggt gtg ttc ctg tgg ggc gta gcc cac tcg atc aat gag        314
Pro Leu Val Gly Val Phe Leu Trp Gly Val Ala His Ser Ile Asn Glu           
                50                  55                  60                

ctc agc cag gtg cct ccc ccg gtg atg ctg ctg cca gat gac ttt aag        362
Leu Ser Gln Val Pro Pro Pro Val Met Leu Leu Pro Asp Asp Phe Lys           
            65                  70                  75                    

gcc agc tcc aag atc aag gtc aac aat cac ctt ttc cac agg gaa aat        410
Ala Ser Ser Lys Ile Lys Val Asn Asn His Leu Phe His Arg Glu Asn           
        80                  85                  90                        

ctg ccc agt cat ttc aag ttc aag gag tat tgt ccc cag gtc ttc agg        458
Leu Pro Ser His Phe Lys Phe Lys Glu Tyr Cys Pro Gln Val Phe Arg           
    95                  100                 105                           

aac ctc cgt gat cga ttt ggc att gat gac caa gat tac ttg gtg tcc        506
Asn Leu Arg Asp Arg Phe Gly Ile Asp Asp Gln Asp Tyr Leu Val Ser           
110                 115                 120                 125           

ctt acc cga aac ccc ccc agc gaa agt gaa ggc agt gat ggt cgc ttc        554
Leu Thr Arg Asn Pro Pro Ser Glu Ser Glu Gly Ser Asp Gly Arg Phe           
                130                 135                 140               

ctt atc tcc tac gat cgg act ctg gtc atc aaa gaa gta tcc agt gag        602
Leu Ile Ser Tyr Asp Arg Thr Leu Val Ile Lys Glu Val Ser Ser Glu           
            145                 150                 155                   

gac att gct gac atg cat agc aac ctc tcc aac tat cac cag tac att        650
Asp Ile Ala Asp Met His Ser Asn Leu Ser Asn Tyr His Gln Tyr Ile           
        160                 165                 170                       

gtg aag tgc cat ggc aac acg ctt ctg ccc cag ttc ctg ggg atg tac        698
Val Lys Cys His Gly Asn Thr Leu Leu Pro Gln Phe Leu Gly Met Tyr           
    175                 180                 185                           

cga gtc agt gtg gac aac gaa gac agc tac atg ctt gtg atg cgc aat        746
Arg Val Ser Val Asp Asn Glu Asp Ser Tyr Met Leu Val Met Arg Asn           
190                 195                 200                 205           

atg ttt agc cac cgt ctt cct gtg cac agg aag tat gac ctc aag ggt        794
Met Phe Ser His Arg Leu Pro Val His Arg Lys Tyr Asp Leu Lys Gly           
                210                 215                 220               

tcc cta gtg tcc cgg gaa gcc agc gat aag gaa aag gtt aaa gaa ttg        842
Ser Leu Val Ser Arg Glu Ala Ser Asp Lys Glu Lys Val Lys Glu Leu           
            225                 230                 235                   

ccc acc ctt aag gat atg gac ttt ctc aac aag aac cag aaa gta tat        890
Pro Thr Leu Lys Asp Met Asp Phe Leu Asn Lys Asn Gln Lys Val Tyr           
        240                 245                 250                       

att ggt gaa gag gag aag aaa ata ttt ctg gag aag ctg aag aga gat        938
Ile Gly Glu Glu Glu Lys Lys Ile Phe Leu Glu Lys Leu Lys Arg Asp           
    255                 260                 265                           

gtg gag ttt cta gtg cag ctg aag atc atg gac tac agc ctt ctg cta        986
Val Glu Phe Leu Val Gln Leu Lys Ile Met Asp Tyr Ser Leu Leu Leu           
270                 275                 280                 285           

ggc atc cac gac atc att cgg ggc tct gaa cca gag gag gaa gcg ccc       1034
Gly Ile His Asp Ile Ile Arg Gly Ser Glu Pro Glu Glu Glu Ala Pro           
                290                 295                 300               

gtg cgg gag gat gag tca gag gtg gat ggg gac tgc agc ctg act gga       1082
Val Arg Glu Asp Glu Ser Glu Val Asp Gly Asp Cys Ser Leu Thr Gly           
            305                 310                 315                   

cct cct gct ctg gtg ggc tcc tat ggc acc tcc cca gag ggt atc gga       1130
Pro Pro Ala Leu Val Gly Ser Tyr Gly Thr Ser Pro Glu Gly Ile Gly           
        320                 325                 330                       

ggc tac atc cat tcc cat cgg ccc ctg ggc cca gga gag ttt gag tcc       1178
Gly Tyr Ile His Ser His Arg Pro Leu Gly Pro Gly Glu Phe Glu Ser           
    335                 340                 345                           

ttc att gat gtc tat gcc atc cgg agt gct gaa gga gcc ccc cag aag       1226
Phe Ile Asp Val Tyr Ala Ile Arg Ser Ala Glu Gly Ala Pro Gln Lys           
350                 355                 360                 365           

gag gtc tac ttc atg ggc ctc att gat atc ctt aca cag tat gat gcc       1274
Glu Val Tyr Phe Met Gly Leu Ile Asp Ile Leu Thr Gln Tyr Asp Ala           
                370                 375                 380               

aag aag aaa gca gct cat gca gcc aaa act gtc aag cat ggg gct ggg       1322
Lys Lys Lys Ala Ala His Ala Ala Lys Thr Val Lys His Gly Ala Gly           
            385                 390                 395                   

gca gag atc tct act gtc cat ccg gag cag tat gct aag cga ttc ctg       1370
Ala Glu Ile Ser Thr Val His Pro Glu Gln Tyr Ala Lys Arg Phe Leu           
        400                 405                 410                       

gat ttt att acc aac atc ttt gcc taa gagactgcct ggttctctct             1417
Asp Phe Ile Thr Asn Ile Phe Ala                                           
    415                 420                                               

gatgttcaag gagctagggg aagggggttg tttgccttct tcaggacctg actggacaga     1477

tggacctggc tcaagcaact actctggatg cactttgctg tgtgggatga actaaaagtg     1537

tctgaatttt gctgataact ttataaaact cactatggca tgcttccctc ctggtgggcc     1597

ctaggatgga tgacactcaa gatactacag atgtgggtgc aggcatgcac acacacgatg     1657

gaatatggcc attcctacac aggtggggta gagagtgggt cagcagcctg gcacctcaca     1717

gaggtgggac ctaagaggac tcatgattat gcagagaatt ggattgggtc tctgtcatag     1777

attgagtaat ctcttccctt acctcaattc catctccacc catctctaca tctgggcaca     1837

gcaacccaga gatggccaaa agcattcaag cctgggggaa gatgtttgac tattgctgct     1897

cttcaccaga acctcacacc tctcctggga ctggaaccct tcagtgggtg tgtggccagt     1957

tttggaggct ggaatgatgg gccagggtgt aggattcatt ctccatgtaa agtttccttt     2017

catcctgcct agccatcccc aaggtttatt tccagaagaa aggaatatct ctacttggat     2077

caattctggt catttcaaga ggatggaggc ctcaagtgtg ggaacttccc ctactccctg     2137

gatgtgtgta cctagcacac ttccttctcc cacccctttt tccagttgga tttgtttttc     2197

tgttctcttc tgtcctgtct tatactgcaa ctgtgtctcc taggggacag atggccttct     2257

ttgtcatctt cactctccac ccccagagag gagtcagagc cataactcaa tcactcagcc     2317

cctccaaaga tagttgatgt gtgataatct cataatgttg agaaccctga tgagatacat     2377

tgtcttcctc tccctacaat gcctctgggg ccaaggcacc cattcttctt gctatcctcc     2437

atcccccttg aggcttccac tttttttttt tttagacata aagctgggca tcagcaactg     2497

gcctgtggtg atgcaaagct gctttgctct gtatctggct ggactgatct gtctcacaag     2557

aagccatgag gccataggga gaagctccct ctccccttca tcttctgctc caaaggtggt     2617

agcaagagga gtacccagtt aggggttgga gcccccatat aacatcttcc tgtcagaaga     2677

ctgatggatc tttttcattc caaccatctc cctttccccc gatgaatgca ataaaactct     2737

gtgacaccag caaccattgc tctttagaaa tgggttttct gatcatatgg ctgatgtgtt     2797

atgggcagta tggatgtctt catttgttgc ttctgttttt catctttttt gttttattaa     2857

taaaaattta tgtatttgct cctgttacta taataataca gggaataaat tattcaatcc     2917

aaatttctgt acaaaaaaaa aaa                                             2940


<210>  28
<211>  421
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Ser Ser Ser Val Pro Pro Ala Thr Val Ser Ala Ala Thr Ala 
1               5                   10                  15      


Gly Pro Gly Pro Gly Phe Gly Phe Ala Ser Lys Thr Lys Lys Lys His 
            20                  25                  30          


Phe Val Gln Gln Lys Val Lys Val Phe Arg Ala Ala Asp Pro Leu Val 
        35                  40                  45              


Gly Val Phe Leu Trp Gly Val Ala His Ser Ile Asn Glu Leu Ser Gln 
    50                  55                  60                  


Val Pro Pro Pro Val Met Leu Leu Pro Asp Asp Phe Lys Ala Ser Ser 
65                  70                  75                  80  


Lys Ile Lys Val Asn Asn His Leu Phe His Arg Glu Asn Leu Pro Ser 
                85                  90                  95      


His Phe Lys Phe Lys Glu Tyr Cys Pro Gln Val Phe Arg Asn Leu Arg 
            100                 105                 110         


Asp Arg Phe Gly Ile Asp Asp Gln Asp Tyr Leu Val Ser Leu Thr Arg 
        115                 120                 125             


Asn Pro Pro Ser Glu Ser Glu Gly Ser Asp Gly Arg Phe Leu Ile Ser 
    130                 135                 140                 


Tyr Asp Arg Thr Leu Val Ile Lys Glu Val Ser Ser Glu Asp Ile Ala 
145                 150                 155                 160 


Asp Met His Ser Asn Leu Ser Asn Tyr His Gln Tyr Ile Val Lys Cys 
                165                 170                 175     


His Gly Asn Thr Leu Leu Pro Gln Phe Leu Gly Met Tyr Arg Val Ser 
            180                 185                 190         


Val Asp Asn Glu Asp Ser Tyr Met Leu Val Met Arg Asn Met Phe Ser 
        195                 200                 205             


His Arg Leu Pro Val His Arg Lys Tyr Asp Leu Lys Gly Ser Leu Val 
    210                 215                 220                 


Ser Arg Glu Ala Ser Asp Lys Glu Lys Val Lys Glu Leu Pro Thr Leu 
225                 230                 235                 240 


Lys Asp Met Asp Phe Leu Asn Lys Asn Gln Lys Val Tyr Ile Gly Glu 
                245                 250                 255     


Glu Glu Lys Lys Ile Phe Leu Glu Lys Leu Lys Arg Asp Val Glu Phe 
            260                 265                 270         


Leu Val Gln Leu Lys Ile Met Asp Tyr Ser Leu Leu Leu Gly Ile His 
        275                 280                 285             


Asp Ile Ile Arg Gly Ser Glu Pro Glu Glu Glu Ala Pro Val Arg Glu 
    290                 295                 300                 


Asp Glu Ser Glu Val Asp Gly Asp Cys Ser Leu Thr Gly Pro Pro Ala 
305                 310                 315                 320 


Leu Val Gly Ser Tyr Gly Thr Ser Pro Glu Gly Ile Gly Gly Tyr Ile 
                325                 330                 335     


His Ser His Arg Pro Leu Gly Pro Gly Glu Phe Glu Ser Phe Ile Asp 
            340                 345                 350         


Val Tyr Ala Ile Arg Ser Ala Glu Gly Ala Pro Gln Lys Glu Val Tyr 
        355                 360                 365             


Phe Met Gly Leu Ile Asp Ile Leu Thr Gln Tyr Asp Ala Lys Lys Lys 
    370                 375                 380                 


Ala Ala His Ala Ala Lys Thr Val Lys His Gly Ala Gly Ala Glu Ile 
385                 390                 395                 400 


Ser Thr Val His Pro Glu Gln Tyr Ala Lys Arg Phe Leu Asp Phe Ile 
                405                 410                 415     


Thr Asn Ile Phe Ala 
            420     


<210>  29
<211>  3175
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (132)..(1343)

<400>  29
tcgccctgtt cgcgcgtccg ctgtccggcc tccggtcacg tgacagcagc gcaggtgagc       60

gccgcttccg gggtcgggcg cctggatagc tgccggctcc ggcttccact tggtcggttg      120

cgcgggagac t atg gcg tcc tcc tcg gtc cca cca gcc acg gta tcg gcg       170
             Met Ala Ser Ser Ser Val Pro Pro Ala Thr Val Ser Ala          
             1               5                   10                       

gcg aca gca ggc ccc ggc cca ggt ttc ggc ttc gcc tcc aag acc aag        218
Ala Thr Ala Gly Pro Gly Pro Gly Phe Gly Phe Ala Ser Lys Thr Lys           
    15                  20                  25                            

aag aag cat ttc gtg cag cag aag gtg aag gtg ttc cgg gcg gcc gac        266
Lys Lys His Phe Val Gln Gln Lys Val Lys Val Phe Arg Ala Ala Asp           
30                  35                  40                  45            

ccg ctg gtg ggt gtg ttc ctg tgg ggc gta gcc cac tcg atc aat gag        314
Pro Leu Val Gly Val Phe Leu Trp Gly Val Ala His Ser Ile Asn Glu           
                50                  55                  60                

ctc agc cag gtg cct ccc ccg gtg atg ctg ctg cca gat gac ttt aag        362
Leu Ser Gln Val Pro Pro Pro Val Met Leu Leu Pro Asp Asp Phe Lys           
            65                  70                  75                    

gcc agc tcc aag atc aag gag tat tgt ccc cag gtc ttc agg aac ctc        410
Ala Ser Ser Lys Ile Lys Glu Tyr Cys Pro Gln Val Phe Arg Asn Leu           
        80                  85                  90                        

cgt gat cga ttt ggc att gat gac caa gat tac ttg gtg tcc ctt acc        458
Arg Asp Arg Phe Gly Ile Asp Asp Gln Asp Tyr Leu Val Ser Leu Thr           
    95                  100                 105                           

cga aac ccc ccc agc gaa agt gaa ggc agt gat ggt cgc ttc ctt atc        506
Arg Asn Pro Pro Ser Glu Ser Glu Gly Ser Asp Gly Arg Phe Leu Ile           
110                 115                 120                 125           

tcc tac gat cgg act ctg gtc atc aaa gaa gta tcc agt gag gac att        554
Ser Tyr Asp Arg Thr Leu Val Ile Lys Glu Val Ser Ser Glu Asp Ile           
                130                 135                 140               

gct gac atg cat agc aac ctc tcc aac tat cac cag tac att gtg aag        602
Ala Asp Met His Ser Asn Leu Ser Asn Tyr His Gln Tyr Ile Val Lys           
            145                 150                 155                   

tgc cat ggc aac acg ctt ctg ccc cag ttc ctg ggg atg tac cga gtc        650
Cys His Gly Asn Thr Leu Leu Pro Gln Phe Leu Gly Met Tyr Arg Val           
        160                 165                 170                       

agt gtg gac aac gaa gac agc tac atg ctt gtg atg cgc aat atg ttt        698
Ser Val Asp Asn Glu Asp Ser Tyr Met Leu Val Met Arg Asn Met Phe           
    175                 180                 185                           

agc cac cgt ctt cct gtg cac agg aag tat gac ctc aag ggt tcc cta        746
Ser His Arg Leu Pro Val His Arg Lys Tyr Asp Leu Lys Gly Ser Leu           
190                 195                 200                 205           

gtg tcc cgg gaa gcc agc gat aag gaa aag gtt aaa gaa ttg ccc acc        794
Val Ser Arg Glu Ala Ser Asp Lys Glu Lys Val Lys Glu Leu Pro Thr           
                210                 215                 220               

ctt aag gat atg gac ttt ctc aac aag aac cag aaa gta tat att ggt        842
Leu Lys Asp Met Asp Phe Leu Asn Lys Asn Gln Lys Val Tyr Ile Gly           
            225                 230                 235                   

gaa gag gag aag aaa ata ttt ctg gag aag ctg aag aga gat gtg gag        890
Glu Glu Glu Lys Lys Ile Phe Leu Glu Lys Leu Lys Arg Asp Val Glu           
        240                 245                 250                       

ttt cta gtg cag ctg aag atc atg gac tac agc ctt ctg cta ggc atc        938
Phe Leu Val Gln Leu Lys Ile Met Asp Tyr Ser Leu Leu Leu Gly Ile           
    255                 260                 265                           

cac gac atc att cgg ggc tct gaa cca gag gag gaa gcg ccc gtg cgg        986
His Asp Ile Ile Arg Gly Ser Glu Pro Glu Glu Glu Ala Pro Val Arg           
270                 275                 280                 285           

gag gat gag tca gag gtg gat ggg gac tgc agc ctg act gga cct cct       1034
Glu Asp Glu Ser Glu Val Asp Gly Asp Cys Ser Leu Thr Gly Pro Pro           
                290                 295                 300               

gct ctg gtg ggc tcc tat ggc acc tcc cca gag ggt atc gga ggc tac       1082
Ala Leu Val Gly Ser Tyr Gly Thr Ser Pro Glu Gly Ile Gly Gly Tyr           
            305                 310                 315                   

atc cat tcc cat cgg ccc ctg ggc cca gga gag ttt gag tcc ttc att       1130
Ile His Ser His Arg Pro Leu Gly Pro Gly Glu Phe Glu Ser Phe Ile           
        320                 325                 330                       

gat gtc tat gcc atc cgg agt gct gaa gga gcc ccc cag aag gag gtc       1178
Asp Val Tyr Ala Ile Arg Ser Ala Glu Gly Ala Pro Gln Lys Glu Val           
    335                 340                 345                           

tac ttc atg ggc ctc att gat atc ctt aca cag tat gat gcc aag aag       1226
Tyr Phe Met Gly Leu Ile Asp Ile Leu Thr Gln Tyr Asp Ala Lys Lys           
350                 355                 360                 365           

aaa gca gct cat gca gcc aaa act gtc aag cat ggg gct ggg gca gag       1274
Lys Ala Ala His Ala Ala Lys Thr Val Lys His Gly Ala Gly Ala Glu           
                370                 375                 380               

atc tct act gtc cat ccg gag cag tat gct aag cga ttc ctg gat ttt       1322
Ile Ser Thr Val His Pro Glu Gln Tyr Ala Lys Arg Phe Leu Asp Phe           
            385                 390                 395                   

att acc aac atc ttt gcc taa gagactgcct ggttctctct gatgttcaag          1373
Ile Thr Asn Ile Phe Ala                                                   
        400                                                               

gtggtggggt tctgagacac ttgggggaat tgtggggata ttctagccac cagttctctt     1433

cttcctttgc taaattcagg ctgcaggctc cttccatcca gataactcca tcctgtcgag     1493

taggctcttt ctgaccctca gaaatacatt gtcctttttc ctctttgccc atttttcttc     1553

cctctcttcc tccccatgag aagtctgctt gtagtattag aatgttattg ttgactctct     1613

cccaagtgcc ttgatctttg taatatctcc tgttgtttct atgatatagg agctagggga     1673

agggggttgt ttgccttctt caggacctga ctggacagat ggacctggct caagcaacta     1733

ctctggatgc actttgctgt gtgggatgaa ctaaaagtgt ctgaattttg ctgataactt     1793

tataaaactc actatggcat gcttccctcc tggtgggccc taggatggat gacactcaag     1853

atactacaga tgtgggtgca ggcatgcaca cacacgatgg aatatggcca ttcctacaca     1913

ggtggggtag agagtgggtc agcagcctgg cacctcacag aggtgggacc taagaggact     1973

catgattatg cagagaattg gattgggtct ctgtcataga ttgagtaatc tcttccctta     2033

cctcaattcc atctccaccc atctctacat ctgggcacag caacccagag atggccaaaa     2093

gcattcaagc ctgggggaag atgtttgact attgctgctc ttcaccagaa cctcacacct     2153

ctcctgggac tggaaccctt cagtgggtgt gtggccagtt ttggaggctg gaatgatggg     2213

ccagggtgta ggattcattc tccatgtaaa gtttcctttc atcctgccta gccatcccca     2273

aggtttattt ccagaagaaa ggaatatctc tacttggatc aattctggtc atttcaagag     2333

gatggaggcc tcaagtgtgg gaacttcccc tactccctgg atgtgtgtac ctagcacact     2393

tccttctccc accccttttt ccagttggat ttgtttttct gttctcttct gtcctgtctt     2453

atactgcaac tgtgtctcct aggggacaga tggccttctt tgtcatcttc actctccacc     2513

cccagagagg agtcagagcc ataactcaat cactcagccc ctccaaagat agttgatgtg     2573

tgataatctc ataatgttga gaaccctgat gagatacatt gtcttcctct ccctacaatg     2633

cctctggggc caaggcaccc attcttcttg ctatcctcca tcccccttga ggcttccact     2693

tttttttttt ttagacataa agctgggcat cagcaactgg cctgtggtga tgcaaagctg     2753

ctttgctctg tatctggctg gactgatctg tctcacaaga agccatgagg ccatagggag     2813

aagctccctc tccccttcat cttctgctcc aaaggtggta gcaagaggag tacccagtta     2873

ggggttggag cccccatata acatcttcct gtcagaagac tgatggatct ttttcattcc     2933

aaccatctcc ctttcccccg atgaatgcaa taaaactctg tgacaccagc aaccattgct     2993

ctttagaaat gggttttctg atcatatggc tgatgtgtta tgggcagtat ggatgtcttc     3053

atttgttgct tctgtttttc atcttttttg ttttattaat aaaaatttat gtatttgctc     3113

ctgttactat aataatacag ggaataaatt attcaatcca aatttctgta caaaaaaaaa     3173

aa                                                                    3175


<210>  30
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Ser Ser Ser Val Pro Pro Ala Thr Val Ser Ala Ala Thr Ala 
1               5                   10                  15      


Gly Pro Gly Pro Gly Phe Gly Phe Ala Ser Lys Thr Lys Lys Lys His 
            20                  25                  30          


Phe Val Gln Gln Lys Val Lys Val Phe Arg Ala Ala Asp Pro Leu Val 
        35                  40                  45              


Gly Val Phe Leu Trp Gly Val Ala His Ser Ile Asn Glu Leu Ser Gln 
    50                  55                  60                  


Val Pro Pro Pro Val Met Leu Leu Pro Asp Asp Phe Lys Ala Ser Ser 
65                  70                  75                  80  


Lys Ile Lys Glu Tyr Cys Pro Gln Val Phe Arg Asn Leu Arg Asp Arg 
                85                  90                  95      


Phe Gly Ile Asp Asp Gln Asp Tyr Leu Val Ser Leu Thr Arg Asn Pro 
            100                 105                 110         


Pro Ser Glu Ser Glu Gly Ser Asp Gly Arg Phe Leu Ile Ser Tyr Asp 
        115                 120                 125             


Arg Thr Leu Val Ile Lys Glu Val Ser Ser Glu Asp Ile Ala Asp Met 
    130                 135                 140                 


His Ser Asn Leu Ser Asn Tyr His Gln Tyr Ile Val Lys Cys His Gly 
145                 150                 155                 160 


Asn Thr Leu Leu Pro Gln Phe Leu Gly Met Tyr Arg Val Ser Val Asp 
                165                 170                 175     


Asn Glu Asp Ser Tyr Met Leu Val Met Arg Asn Met Phe Ser His Arg 
            180                 185                 190         


Leu Pro Val His Arg Lys Tyr Asp Leu Lys Gly Ser Leu Val Ser Arg 
        195                 200                 205             


Glu Ala Ser Asp Lys Glu Lys Val Lys Glu Leu Pro Thr Leu Lys Asp 
    210                 215                 220                 


Met Asp Phe Leu Asn Lys Asn Gln Lys Val Tyr Ile Gly Glu Glu Glu 
225                 230                 235                 240 


Lys Lys Ile Phe Leu Glu Lys Leu Lys Arg Asp Val Glu Phe Leu Val 
                245                 250                 255     


Gln Leu Lys Ile Met Asp Tyr Ser Leu Leu Leu Gly Ile His Asp Ile 
            260                 265                 270         


Ile Arg Gly Ser Glu Pro Glu Glu Glu Ala Pro Val Arg Glu Asp Glu 
        275                 280                 285             


Ser Glu Val Asp Gly Asp Cys Ser Leu Thr Gly Pro Pro Ala Leu Val 
    290                 295                 300                 


Gly Ser Tyr Gly Thr Ser Pro Glu Gly Ile Gly Gly Tyr Ile His Ser 
305                 310                 315                 320 


His Arg Pro Leu Gly Pro Gly Glu Phe Glu Ser Phe Ile Asp Val Tyr 
                325                 330                 335     


Ala Ile Arg Ser Ala Glu Gly Ala Pro Gln Lys Glu Val Tyr Phe Met 
            340                 345                 350         


Gly Leu Ile Asp Ile Leu Thr Gln Tyr Asp Ala Lys Lys Lys Ala Ala 
        355                 360                 365             


His Ala Ala Lys Thr Val Lys His Gly Ala Gly Ala Glu Ile Ser Thr 
    370                 375                 380                 


Val His Pro Glu Gln Tyr Ala Lys Arg Phe Leu Asp Phe Ile Thr Asn 
385                 390                 395                 400 


Ile Phe Ala 
            


<210>  31
<211>  3085
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (132)..(1253)

<400>  31
tcgccctgtt cgcgcgtccg ctgtccggcc tccggtcacg tgacagcagc gcaggtgagc       60

gccgcttccg gggtcgggcg cctggatagc tgccggctcc ggcttccact tggtcggttg      120

cgcgggagac t atg gcg tcc tcc tcg gtc cca cca gcc acg gta tcg gcg       170
             Met Ala Ser Ser Ser Val Pro Pro Ala Thr Val Ser Ala          
             1               5                   10                       

gcg aca gca ggc ccc ggc cca ggt ttc ggc ttc gcc tcc aag acc aag        218
Ala Thr Ala Gly Pro Gly Pro Gly Phe Gly Phe Ala Ser Lys Thr Lys           
    15                  20                  25                            

aag aag cat ttc gtg cag cag aag gtg aag gtg ttc cgg gcg gcc gac        266
Lys Lys His Phe Val Gln Gln Lys Val Lys Val Phe Arg Ala Ala Asp           
30                  35                  40                  45            

ccg ctg gtg ggt gtg ttc ctg tgg ggc gta gcc cac tcg atc aat gag        314
Pro Leu Val Gly Val Phe Leu Trp Gly Val Ala His Ser Ile Asn Glu           
                50                  55                  60                

ctc agc cag gtg cct ccc ccg gtg atg ctg ctg cca gat gac ttt aag        362
Leu Ser Gln Val Pro Pro Pro Val Met Leu Leu Pro Asp Asp Phe Lys           
            65                  70                  75                    

gcc agc tcc aag atc aag gtc aac aat cac ctt ttc cac agg gaa aat        410
Ala Ser Ser Lys Ile Lys Val Asn Asn His Leu Phe His Arg Glu Asn           
        80                  85                  90                        

ctg ccc agt cat ttc aag ttc aag gag tat tgt ccc cag gtc ttc agg        458
Leu Pro Ser His Phe Lys Phe Lys Glu Tyr Cys Pro Gln Val Phe Arg           
    95                  100                 105                           

aac ctc cgt gat cga ttt ggc att gat gac caa gat tac ttg tac att        506
Asn Leu Arg Asp Arg Phe Gly Ile Asp Asp Gln Asp Tyr Leu Tyr Ile           
110                 115                 120                 125           

gtg aag tgc cat ggc aac acg ctt ctg ccc cag ttc ctg ggg atg tac        554
Val Lys Cys His Gly Asn Thr Leu Leu Pro Gln Phe Leu Gly Met Tyr           
                130                 135                 140               

cga gtc agt gtg gac aac gaa gac agc tac atg ctt gtg atg cgc aat        602
Arg Val Ser Val Asp Asn Glu Asp Ser Tyr Met Leu Val Met Arg Asn           
            145                 150                 155                   

atg ttt agc cac cgt ctt cct gtg cac agg aag tat gac ctc aag ggt        650
Met Phe Ser His Arg Leu Pro Val His Arg Lys Tyr Asp Leu Lys Gly           
        160                 165                 170                       

tcc cta gtg tcc cgg gaa gcc agc gat aag gaa aag gtt aaa gaa ttg        698
Ser Leu Val Ser Arg Glu Ala Ser Asp Lys Glu Lys Val Lys Glu Leu           
    175                 180                 185                           

ccc acc ctt aag gat atg gac ttt ctc aac aag aac cag aaa gta tat        746
Pro Thr Leu Lys Asp Met Asp Phe Leu Asn Lys Asn Gln Lys Val Tyr           
190                 195                 200                 205           

att ggt gaa gag gag aag aaa ata ttt ctg gag aag ctg aag aga gat        794
Ile Gly Glu Glu Glu Lys Lys Ile Phe Leu Glu Lys Leu Lys Arg Asp           
                210                 215                 220               

gtg gag ttt cta gtg cag ctg aag atc atg gac tac agc ctt ctg cta        842
Val Glu Phe Leu Val Gln Leu Lys Ile Met Asp Tyr Ser Leu Leu Leu           
            225                 230                 235                   

ggc atc cac gac atc att cgg ggc tct gaa cca gag gag gaa gcg ccc        890
Gly Ile His Asp Ile Ile Arg Gly Ser Glu Pro Glu Glu Glu Ala Pro           
        240                 245                 250                       

gtg cgg gag gat gag tca gag gtg gat ggg gac tgc agc ctg act gga        938
Val Arg Glu Asp Glu Ser Glu Val Asp Gly Asp Cys Ser Leu Thr Gly           
    255                 260                 265                           

cct cct gct ctg gtg ggc tcc tat ggc acc tcc cca gag ggt atc gga        986
Pro Pro Ala Leu Val Gly Ser Tyr Gly Thr Ser Pro Glu Gly Ile Gly           
270                 275                 280                 285           

ggc tac atc cat tcc cat cgg ccc ctg ggc cca gga gag ttt gag tcc       1034
Gly Tyr Ile His Ser His Arg Pro Leu Gly Pro Gly Glu Phe Glu Ser           
                290                 295                 300               

ttc att gat gtc tat gcc atc cgg agt gct gaa gga gcc ccc cag aag       1082
Phe Ile Asp Val Tyr Ala Ile Arg Ser Ala Glu Gly Ala Pro Gln Lys           
            305                 310                 315                   

gag gtc tac ttc atg ggc ctc att gat atc ctt aca cag tat gat gcc       1130
Glu Val Tyr Phe Met Gly Leu Ile Asp Ile Leu Thr Gln Tyr Asp Ala           
        320                 325                 330                       

aag aag aaa gca gct cat gca gcc aaa act gtc aag cat ggg gct ggg       1178
Lys Lys Lys Ala Ala His Ala Ala Lys Thr Val Lys His Gly Ala Gly           
    335                 340                 345                           

gca gag atc tct act gtc cat ccg gag cag tat gct aag cga ttc ctg       1226
Ala Glu Ile Ser Thr Val His Pro Glu Gln Tyr Ala Lys Arg Phe Leu           
350                 355                 360                 365           

gat ttt att acc aac atc ttt gcc taa gagactgcct ggttctctct             1273
Asp Phe Ile Thr Asn Ile Phe Ala                                           
                370                                                       

gatgttcaag gtggtggggt tctgagacac ttgggggaat tgtggggata ttctagccac     1333

cagttctctt cttcctttgc taaattcagg ctgcaggctc cttccatcca gataactcca     1393

tcctgtcgag taggctcttt ctgaccctca gaaatacatt gtcctttttc ctctttgccc     1453

atttttcttc cctctcttcc tccccatgag aagtctgctt gtagtattag aatgttattg     1513

ttgactctct cccaagtgcc ttgatctttg taatatctcc tgttgtttct atgatatagg     1573

agctagggga agggggttgt ttgccttctt caggacctga ctggacagat ggacctggct     1633

caagcaacta ctctggatgc actttgctgt gtgggatgaa ctaaaagtgt ctgaattttg     1693

ctgataactt tataaaactc actatggcat gcttccctcc tggtgggccc taggatggat     1753

gacactcaag atactacaga tgtgggtgca ggcatgcaca cacacgatgg aatatggcca     1813

ttcctacaca ggtggggtag agagtgggtc agcagcctgg cacctcacag aggtgggacc     1873

taagaggact catgattatg cagagaattg gattgggtct ctgtcataga ttgagtaatc     1933

tcttccctta cctcaattcc atctccaccc atctctacat ctgggcacag caacccagag     1993

atggccaaaa gcattcaagc ctgggggaag atgtttgact attgctgctc ttcaccagaa     2053

cctcacacct ctcctgggac tggaaccctt cagtgggtgt gtggccagtt ttggaggctg     2113

gaatgatggg ccagggtgta ggattcattc tccatgtaaa gtttcctttc atcctgccta     2173

gccatcccca aggtttattt ccagaagaaa ggaatatctc tacttggatc aattctggtc     2233

atttcaagag gatggaggcc tcaagtgtgg gaacttcccc tactccctgg atgtgtgtac     2293

ctagcacact tccttctccc accccttttt ccagttggat ttgtttttct gttctcttct     2353

gtcctgtctt atactgcaac tgtgtctcct aggggacaga tggccttctt tgtcatcttc     2413

actctccacc cccagagagg agtcagagcc ataactcaat cactcagccc ctccaaagat     2473

agttgatgtg tgataatctc ataatgttga gaaccctgat gagatacatt gtcttcctct     2533

ccctacaatg cctctggggc caaggcaccc attcttcttg ctatcctcca tcccccttga     2593

ggcttccact tttttttttt ttagacataa agctgggcat cagcaactgg cctgtggtga     2653

tgcaaagctg ctttgctctg tatctggctg gactgatctg tctcacaaga agccatgagg     2713

ccatagggag aagctccctc tccccttcat cttctgctcc aaaggtggta gcaagaggag     2773

tacccagtta ggggttggag cccccatata acatcttcct gtcagaagac tgatggatct     2833

ttttcattcc aaccatctcc ctttcccccg atgaatgcaa taaaactctg tgacaccagc     2893

aaccattgct ctttagaaat gggttttctg atcatatggc tgatgtgtta tgggcagtat     2953

ggatgtcttc atttgttgct tctgtttttc atcttttttg ttttattaat aaaaatttat     3013

gtatttgctc ctgttactat aataatacag ggaataaatt attcaatcca aatttctgta     3073

caaaaaaaaa aa                                                         3085


<210>  32
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Ser Ser Ser Val Pro Pro Ala Thr Val Ser Ala Ala Thr Ala 
1               5                   10                  15      


Gly Pro Gly Pro Gly Phe Gly Phe Ala Ser Lys Thr Lys Lys Lys His 
            20                  25                  30          


Phe Val Gln Gln Lys Val Lys Val Phe Arg Ala Ala Asp Pro Leu Val 
        35                  40                  45              


Gly Val Phe Leu Trp Gly Val Ala His Ser Ile Asn Glu Leu Ser Gln 
    50                  55                  60                  


Val Pro Pro Pro Val Met Leu Leu Pro Asp Asp Phe Lys Ala Ser Ser 
65                  70                  75                  80  


Lys Ile Lys Val Asn Asn His Leu Phe His Arg Glu Asn Leu Pro Ser 
                85                  90                  95      


His Phe Lys Phe Lys Glu Tyr Cys Pro Gln Val Phe Arg Asn Leu Arg 
            100                 105                 110         


Asp Arg Phe Gly Ile Asp Asp Gln Asp Tyr Leu Tyr Ile Val Lys Cys 
        115                 120                 125             


His Gly Asn Thr Leu Leu Pro Gln Phe Leu Gly Met Tyr Arg Val Ser 
    130                 135                 140                 


Val Asp Asn Glu Asp Ser Tyr Met Leu Val Met Arg Asn Met Phe Ser 
145                 150                 155                 160 


His Arg Leu Pro Val His Arg Lys Tyr Asp Leu Lys Gly Ser Leu Val 
                165                 170                 175     


Ser Arg Glu Ala Ser Asp Lys Glu Lys Val Lys Glu Leu Pro Thr Leu 
            180                 185                 190         


Lys Asp Met Asp Phe Leu Asn Lys Asn Gln Lys Val Tyr Ile Gly Glu 
        195                 200                 205             


Glu Glu Lys Lys Ile Phe Leu Glu Lys Leu Lys Arg Asp Val Glu Phe 
    210                 215                 220                 


Leu Val Gln Leu Lys Ile Met Asp Tyr Ser Leu Leu Leu Gly Ile His 
225                 230                 235                 240 


Asp Ile Ile Arg Gly Ser Glu Pro Glu Glu Glu Ala Pro Val Arg Glu 
                245                 250                 255     


Asp Glu Ser Glu Val Asp Gly Asp Cys Ser Leu Thr Gly Pro Pro Ala 
            260                 265                 270         


Leu Val Gly Ser Tyr Gly Thr Ser Pro Glu Gly Ile Gly Gly Tyr Ile 
        275                 280                 285             


His Ser His Arg Pro Leu Gly Pro Gly Glu Phe Glu Ser Phe Ile Asp 
    290                 295                 300                 


Val Tyr Ala Ile Arg Ser Ala Glu Gly Ala Pro Gln Lys Glu Val Tyr 
305                 310                 315                 320 


Phe Met Gly Leu Ile Asp Ile Leu Thr Gln Tyr Asp Ala Lys Lys Lys 
                325                 330                 335     


Ala Ala His Ala Ala Lys Thr Val Lys His Gly Ala Gly Ala Glu Ile 
            340                 345                 350         


Ser Thr Val His Pro Glu Gln Tyr Ala Lys Arg Phe Leu Asp Phe Ile 
        355                 360                 365             


Thr Asn Ile Phe Ala 
    370             


