                         SEQUENCE LISTING

<110>  Zealand Pharma A/S
 
<120>  GLP-1/GLP-2 DUAL AGONISTS

<130>  GRF/FP7327562

<140>  PCT/EP2017/082289
<141>  2017-12-11

<150>  DK PA201600756
<151>  2016-12-09

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  33
<212>  PRT
<213>  Homo sapiens glucagon-like peptide 2 (GLP-2)

<400>  1

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  2
<211>  31
<212>  PRT
<213>  Homo sapiens glucagon-like peptide 1 (GLP-1)

<400>  2

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  3
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib or G

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is S or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is S or T

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is S, E or D

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is L, M or V

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is A, N or S

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is D or E

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is E, A or G

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Q, E, L or K

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is A, V or S

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is R or K

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is D, L or E

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is A, N or S

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is I, Y, Q, H or K

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is A, E, H, Y, L, K, Q, R or S

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is H, Y, K or Q

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa is D or E

<400>  3

His Xaa Glu Gly Xaa Phe Xaa Xaa Glu Xaa Xaa Thr Ile Leu Xaa Xaa 
1               5                   10                  15      


Xaa Ala Xaa Xaa Xaa Phe Ile Xaa Trp Leu Xaa Xaa Xaa Lys Ile Thr 
            20                  25                  30          


Xaa 
    


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide

<400>  4

Ser Glu Leu Ala Thr Ile Leu Asp Glu Gln Ala Ala Arg Asp Phe Ile 
1               5                   10                  15      


Ala 
    


<210>  5
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<220>
<221>  misc
<222>  (5)..(5)
<223>  Xaa is S or T

<220>
<221>  misc
<222>  (7)..(7)
<223>  Xaa is S or T

<220>
<221>  misc
<222>  (28)..(28)
<223>  Xaa is A, E, H, Y or L

<220>
<221>  misc
<222>  (29)..(29)
<223>  Xaa is H, Y or Q

<400>  5

His Xaa Glu Gly Xaa Phe Xaa Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Xaa Xaa Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  6
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  6

His Xaa Glu Gly Ser Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  7
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  7

His Xaa Glu Gly Thr Phe Ser Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  8
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  8

His Xaa Glu Gly Thr Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  9
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  9

His Xaa Glu Gly Ser Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Glu His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  10
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  10

His Xaa Glu Gly Thr Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Glu His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  11
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  11

His Xaa Glu Gly Ser Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile His His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  12
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  12

His Xaa Glu Gly Ser Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Tyr His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  13
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  13

His Xaa Glu Gly Ser Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Leu His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  14
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  14

His Xaa Glu Gly Thr Phe Thr Asp Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  15
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  15

His Xaa Glu Gly Thr Phe Thr Ser Glu Leu Ser Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  16
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  16

His Xaa Glu Gly Thr Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Gly 
1               5                   10                  15      


Lys Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  17
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  17

His Xaa Glu Gly Thr Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu His Ala His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  18
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  18

His Xaa Glu Gly Thr Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Gln Ala His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  19
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  19

His Xaa Glu Gly Thr Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Tyr Ala His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  20
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  20

His Xaa Glu Gly Thr Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  21
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  21

His Xaa Glu Gly Thr Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Lys His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  22
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  22

His Xaa Glu Gly Thr Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Arg His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  23
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  23

His Xaa Glu Gly Thr Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ser His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  24
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  24

His Xaa Glu Gly Thr Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Gln Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  25
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  25

His Xaa Glu Gly Thr Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Tyr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  26
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  26

His Xaa Glu Gly Thr Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu His Gln His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  27
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  27

His Xaa Glu Gly Ser Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu His Ala His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  28
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  28

His Xaa Glu Gly Ser Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Tyr Glu His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  29
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  29

His Xaa Glu Gly Ser Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Gln Ala His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  30
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  30

His Xaa Glu Gly Ser Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala Gln Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  31
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  31

His Xaa Glu Gly Thr Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Gln Ala Gln Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  32
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  32

His Xaa Glu Gly Thr Phe Thr Ser Glu Leu Ser Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu His Ala Gln Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  33
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  33

His Xaa Glu Gly Ser Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Tyr Ala His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  34
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  34

His Xaa Glu Gly Thr Phe Thr Asp Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Gln Ala Gln Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  35
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  35

His Xaa Glu Gly Ser Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Tyr Arg His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  36
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  36

His Xaa Glu Gly Ser Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Gly 
1               5                   10                  15      


Lys Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  37
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  37

His Xaa Glu Gly Thr Phe Ser Ser Glu Leu Ala Thr Ile Leu Asp Gly 
1               5                   10                  15      


Lys Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  38
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  38

His Xaa Glu Gly Thr Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Ala His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  39
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  39

His Xaa Glu Gly Thr Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ser Trp Leu Ile Ala His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  40
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  40

His Xaa Glu Gly Thr Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Asn Trp Leu Lys Ala His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  41
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  41

His Xaa Glu Gly Thr Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Asn Trp Leu Lys Ser Tyr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  42
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  42

His Xaa Glu Gly Thr Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Asn Trp Leu Lys Glu Gln Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  43
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide

<400>  43

His Gly Glu Gly Thr Phe Thr Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Ala His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  44
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  44

His Xaa Glu Gly Thr Phe Ser Ser Glu Leu Ser Thr Ile Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ser Arg Glu Phe Ile Ala Trp Leu Ile Ala His Lys Ile Thr 
            20                  25                  30          


Glu 
    


<210>  45
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide

<400>  45

His Gly Glu Gly Ser Phe Ser Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln His Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  46
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLP-1/GLP-2 Dual Agonist peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  46

His Xaa Glu Gly Ser Phe Ser Ser Glu Leu Ala Thr Ile Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Arg Asp Phe Ile Ala Trp Leu Ile Gln His Lys Ile Thr 
            20                  25                  30          


Asp 
    


