                         SEQUENCE LISTING

<110>  OSE IMMUNOTHERAPEUTICS
 
<120>  Antibodies and polypeptides directed against CD127

<130>  B12201A

<150>  EP 16306655.8
<151>  2016-12-09

<160>  96    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  1

Phe Thr Leu Ser Asp Tyr Tyr Met Ala 
1               5                   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  2

Thr Ile Ser Ala Ser Gly Leu Arg Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  3

Pro Leu Ser Ala His Tyr Gly Phe Asn Tyr Phe Asp Tyr 
1               5                   10              


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  4

Arg Thr Ser Glu Asp Ile Tyr Gln Gly Leu Ala 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  5

Ser Ala Asn Thr Leu His Ile 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  6

Gln Gln Tyr Tyr Asp Tyr Pro Leu Ala 
1               5                   


<210>  7
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  7

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Leu Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ala Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ala Ser Gly Leu Arg Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Leu Ser Ala His Tyr Gly Phe Asn Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  8
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  8

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Glu Asp Ile Tyr Gln Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Asn Thr Leu His Ile Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Leu 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  9
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asp Ile Tyr Gln Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Val 
        35                  40                  45              


Tyr Ser Ala Asn Thr Leu His Ile Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Tyr Asp Tyr Pro Leu 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  10
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asp Ile Tyr Gln Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Leu 
        35                  40                  45              


Tyr Ser Ala Asn Thr Leu His Ile Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Tyr Asp Tyr Pro Leu 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  11
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asp Ile Tyr Gln Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Val 
        35                  40                  45              


Tyr Ser Ala Asn Thr Leu His Ile Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Leu 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  12
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Glu Asp Ile Tyr Gln Gly 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Leu 
        35                  40                  45              


Tyr Ser Ala Asn Thr Leu His Ile Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Leu 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  13
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  13
caggtgcagc tggtcgaatc agggggggga ctggtcaaac ccgggggctc actgcgtctg       60

tcatgtgccg tctcaggctt cacactgagc gactactata tggcatggat ccgacaggca      120

ccaggcaagg gactggagtg ggtgtctact atttctgcca gtggcctgag gacctactat      180

cctgacagtg tcaagggaag gttcacaatc tcacgggata acgctaaaaa ttccctgtac      240

ctgcagatga acagcctgag agccgaagac accgctgtgt actattgcgc tcgcccactg      300

tccgcacact atggcttcaa ttactttgat tattgggggc agggtaccct ggtgacagtc      360

tccagc                                                                 366


<210>  14
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  14
gagatcgtca tgacgcagtc ccccgcaacg ctctccgtct ccccggggga acgcgcgacc       60

ctgtcgtgca ggacctccga ggacatctac caaggcctcg cgtggtatca gcagaagccc      120

ggccaggccc cgcggctgtt gatctactcc gcgaacacct tgcacatcgg catcccggcg      180

cgcttctcgg ggtcagggag cggcaccgag ttcaccctga ccatctcgtc gctccagagc      240

gaggacttcg ccgtgtacta ctgccagcag tactacgact accccctggc gttcgggggc      300

gggaccaagg tggagatcaa g                                                321


<210>  15
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  15
gacattcaga tgacccagtc cccctcgagc ctgagtgcga gtgtgggcga ccgcgtgacg       60

atcacctgcc ggacgtccga ggatatctac cagggcctcg cctggtacca gcagaagccg      120

ggcaaggccc ccaaactgct ggtctacagc gcgaacaccc tccacatcgg cgtccccagc      180

cggttcagcg gctccggctc gggaacggac tacaccctca cgatctcgtc cctgcagccg      240

gaagacttcg ccacctactt ctgccagcag tattacgact acccgctggc gttcggtggc      300

ggcaccaagg tcgagatcaa g                                                321


<210>  16
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  16
gacattcaga tgacccagtc cccctcgagc ctgagtgcga gtgtgggcga ccgcgtgacg       60

atcacctgcc ggacgtccga ggatatctac cagggcctcg cctggtacca gcagaagccg      120

ggcaaggccc ccaaactgct gctctacagc gcgaacaccc tccacatcgg cgtccccagc      180

cggttcagcg gctccggctc gggaacggac tacaccctca cgatctcgtc cctgcagccg      240

gaagacttcg ccacctactt ctgccagcag tattacgact acccgctggc gttcggtggc      300

ggcaccaagg tcgagatcaa g                                                321


<210>  17
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  17
gacattcaga tgacccagtc cccctcgagc ctgagtgcga gtgtgggcga ccgcgtgacg       60

atcacctgcc ggacgtccga ggatatctac cagggcctcg cctggtacca gcagaagccg      120

ggcaaggccc ccaaactgct ggtctacagc gcgaacaccc tccacatcgg cgtccccagc      180

cggttcagcg gctccggctc gggaacggac tacaccctca cgatctcgtc cctgcagccg      240

gaagacttcg ccacctacta ctgccagcag tattacgact acccgctggc gttcggtggc      300

ggcaccaagg tcgagatcaa g                                                321


<210>  18
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  18
gacattcaga tgacccagtc cccctcgagc ctgagtgcga gtgtgggcga ccgcgtgacg       60

atcacctgcc ggacgtccga ggatatctac cagggcctcg cctggtacca gcagaagccg      120

ggcaaggccc ccaaactgct gctctacagc gcgaacaccc tccacatcgg cgtccccagc      180

cggttcagcg gctccggctc gggaacggac tacaccctca cgatctcgtc cctgcagccg      240

gaagacttcg ccacctacta ctgccagcag tattacgact acccgctggc gttcggtggc      300

ggcaccaagg tcgagatcaa g                                                321


<210>  19
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  19

Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
1               5                   10                  15      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val 
            20                  25                  30      


<210>  20
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  20

Tyr Glu Ile Lys Val Arg Ser Ile Pro Asp His Tyr Phe Lys Gly Phe 
1               5                   10                  15      


Trp Ser Glu Trp Ser Pro Ser Tyr Tyr Phe Arg Thr Pro Glu Ile 
            20                  25                  30      


<210>  21
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu 
                245                 250                 255     


Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val 
            260                 265                 270         


Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
        275                 280                 285             


Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu 
    290                 295                 300                 


Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val 
305                 310                 315                 320 


Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
                325                 330                 335     


Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
            340                 345                 350         


Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
        355                 360                 365             


Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
    370                 375                 380                 


Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
385                 390                 395                 400 


Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
                405                 410                 415     


Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
            420                 425                 430         


Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
        435                 440                 445             


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    450                 455                 


<210>  22
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  22

Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp Ala Glu Leu Asp 
1               5                   10                  15      


Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val Asn Gly Ser Gln 
            20                  25                  30          


His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val Asn Thr Thr Asn 
        35                  40                  45              


Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val Lys Cys Leu Asn 
    50                  55                  60                  


Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr Lys Lys Phe Leu 
65                  70                  75                  80  


Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly Glu Lys Ser Leu 
                85                  90                  95      


Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys Pro Glu Ala Pro 
            100                 105                 110         


Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn Asp Phe Val Val 
        115                 120                 125             


Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val Lys Val Leu Met 
    130                 135                 140                 


His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn Lys Trp Thr His 
145                 150                 155                 160 


Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln Arg Lys Leu Gln 
                165                 170                 175     


Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile Pro Asp His Tyr 
            180                 185                 190         


Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr Tyr Phe Arg Thr 
        195                 200                 205             


Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp 
    210                 215                 


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  23

Phe Ile Glu Thr Lys Lys Phe 
1               5           


<210>  24
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  24

Asp Leu Ser Val Ile Tyr 
1               5       


<210>  25
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  25

Phe Lys Gly Phe 
1               


<210>  26
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  26

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Pro Gly Lys 
                325         


<210>  27
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  27

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  28
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  28

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  29
<211>  984
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  29
gctagcacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      300

aaatatggtc ccccatgccc accatgccca gcacctgagt tcctgggggg accatcagtc      360

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      420

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      480

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      540

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa      660

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      720

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      780

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      840

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg      900

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc      960

ctctccctgt ctccgggtaa atga                                             984


<210>  30
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  30
cgcacggtgg ccgcgccgtc ggtgttcata ttcccgccga gcgacgagca gttgaagtcc       60

ggcaccgcct ccgtcgtgtg cctgctcaac aacttctacc cccgcgaggc gaaggtgcag      120

tggaaggtgg acaacgccct ccagtcgggc aacagtcagg agagcgtcac ggagcaggac      180

tccaaggact cgacatactc cctgtcctcg acgctgacct tgagcaaagc cgattacgag      240

aagcacaagg tgtacgcgtg cgaggtgacc catcagggcc tgtcctcccc ggtgaccaag      300

tccttcaacc ggggcgaatg ctgat                                            325


<210>  31
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  31
acggtggccg cgccgtcggt gttcatattc ccgccgagcg acgagcagtt gaagtccggc       60

accgcctccg tcgtgtgcct gctcaacaac ttctaccccc gcgaggcgaa ggtgcagtgg      120

aaggtggaca acgccctcca gtcgggcaac agtcaggaga gcgtcacgga gcaggactcc      180

aaggactcga catactccct gtcctcgacg ctgaccttga gcaaagccga ttacgagaag      240

cacaaggtgt acgcgtgcga ggtgacccat cagggcctgt cctccccggt gaccaagtcc      300

ttcaaccggg gcgaatgctg at                                               322


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  32

Phe Asp Leu Ser Val Ile Tyr Arg Glu 
1               5                   


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  33

Asn Asp Phe Val Val Thr Phe Asn Thr Ser 
1               5                   10  


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  34

Thr Lys Leu Thr Leu Leu Gln Arg 
1               5               


<210>  35
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  35

Thr Leu Leu Gln Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile 
1               5                   10                  15  


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  36

Leu Val Glu Val Lys Cys Leu Asn Phe Arg 
1               5                   10  


<210>  37
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  37

Ile Cys Gly Ala Leu Val Glu Val Lys Cys Leu Asn Phe Arg 
1               5                   10                  


<210>  38
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  38

Leu Val Glu Val Lys Cys Leu Asn Phe Arg Lys 
1               5                   10      


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  39

Lys Lys Phe Leu Leu Ile Gly 
1               5           


<210>  40
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  40

Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile 
1               5                   10      


<210>  41
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  41

Phe Ile Glu Thr Lys Lys Phe Leu Leu Ile Gly 
1               5                   10      


<210>  42
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  42

Cys Leu Asn Phe Arg 
1               5   


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  43

Phe Ile Glu Thr Lys Lys Phe 
1               5           


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  44

Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp Ala Glu Leu 
1               5                   10                  15  


<210>  45
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  45

Ala Gln Asn Gly Asp Leu Glu Asp Ala Glu Leu Asp Asp Tyr Ser 
1               5                   10                  15  


<210>  46
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  46

Asp Leu Glu Asp Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr 
1               5                   10                  15  


<210>  47
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  47

Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu 
1               5                   10                  15  


<210>  48
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  48

Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val Asn Gly Ser 
1               5                   10                  15  


<210>  49
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  49

Ser Cys Tyr Ser Gln Leu Glu Val Asn Gly Ser Gln His Ser Leu 
1               5                   10                  15  


<210>  50
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  50

Gln Leu Glu Val Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe 
1               5                   10                  15  


<210>  51
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  51

Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp 
1               5                   10                  15  


<210>  52
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  52

His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val Asn Thr Thr 
1               5                   10                  15  


<210>  53
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  53

Cys Ala Phe Glu Asp Pro Asp Val Asn Thr Thr Asn Leu Glu Phe 
1               5                   10                  15  


<210>  54
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  54

Asp Pro Asp Val Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly 
1               5                   10                  15  


<210>  55
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  55

Asn Thr Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu 
1               5                   10                  15  


<210>  56
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  56

Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val Lys Cys Leu 
1               5                   10                  15  


<210>  57
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  57

Ile Cys Gly Ala Leu Val Glu Val Lys Cys Leu Asn Phe Arg Lys 
1               5                   10                  15  


<210>  58
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  58

Leu Val Glu Val Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile 
1               5                   10                  15  


<210>  59
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  59

Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu 
1               5                   10                  15  


<210>  60
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  60

Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr Lys Lys Phe 
1               5                   10                  15  


<210>  61
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  61

Gln Glu Ile Tyr Phe Ile Glu Thr Lys Lys Phe Leu Leu Ile Gly 
1               5                   10                  15  


<210>  62
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  62

Phe Ile Glu Thr Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile 
1               5                   10                  15  


<210>  63
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  63

Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val 
1               5                   10                  15  


<210>  64
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  64

Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly Glu Lys Ser 
1               5                   10                  15  


<210>  65
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  65

Ser Asn Ile Cys Val Lys Val Gly Glu Lys Ser Leu Thr Cys Lys 
1               5                   10                  15  


<210>  66
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  66

Val Lys Val Gly Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu 
1               5                   10                  15  


<210>  67
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  67

Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val 
1               5                   10                  15  


<210>  68
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  68

Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys Pro Glu Ala 
1               5                   10                  15  


<210>  69
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  69

Ile Asp Leu Thr Thr Ile Val Lys Pro Glu Ala Pro Phe Asp Leu 
1               5                   10                  15  


<210>  70
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  70

Thr Ile Val Lys Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr 
1               5                   10                  15  


<210>  71
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  71

Pro Glu Ala Pro Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala 
1               5                   10                  15  


<210>  72
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  72

Phe Asp Leu Ser Val Ile Tyr Arg Glu Gly Ala Asn Asp Phe Val 
1               5                   10                  15  


<210>  73
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  73

Val Ile Tyr Arg Glu Gly Ala Asn Asp Phe Val Val Thr Phe Asn 
1               5                   10                  15  


<210>  74
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  74

Glu Gly Ala Asn Asp Phe Val Val Thr Phe Asn Thr Ser His Leu 
1               5                   10                  15  


<210>  75
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  75

Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr 
1               5                   10                  15  


<210>  76
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  76

Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val Lys Val Leu 
1               5                   10                  15  


<210>  77
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  77

Ser His Leu Gln Lys Lys Tyr Val Lys Val Leu Met His Asp Val 
1               5                   10                  15  


<210>  78
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  78

Lys Lys Tyr Val Lys Val Leu Met His Asp Val Ala Tyr Arg Gln 
1               5                   10                  15  


<210>  79
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  79

Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu 
1               5                   10                  15  


<210>  80
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  80

His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn Lys Trp Thr 
1               5                   10                  15  


<210>  81
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  81

Tyr Arg Gln Glu Lys Asp Glu Asn Lys Trp Thr His Val Asn Leu 
1               5                   10                  15  


<210>  82
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  82

Lys Asp Glu Asn Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys 
1               5                   10                  15  


<210>  83
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  83

Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu 
1               5                   10                  15  


<210>  84
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  84

Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln Arg Lys Leu 
1               5                   10                  15  


<210>  85
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  85

Ser Thr Lys Leu Thr Leu Leu Gln Arg Lys Leu Gln Pro Ala Ala 
1               5                   10                  15  


<210>  86
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  86

Thr Leu Leu Gln Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile 
1               5                   10                  15  


<210>  87
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  87

Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser 
1               5                   10                  15  


<210>  88
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  88

Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile Pro Asp His 
1               5                   10                  15  


<210>  89
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  89

Tyr Glu Ile Lys Val Arg Ser Ile Pro Asp His Tyr Phe Lys Gly 
1               5                   10                  15  


<210>  90
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  90

Val Arg Ser Ile Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu 
1               5                   10                  15  


<210>  91
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  91

Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser 
1               5                   10                  15  


<210>  92
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  92

Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr Tyr Phe Arg 
1               5                   10                  15  


<210>  93
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  93

Trp Ser Glu Trp Ser Pro Ser Tyr Tyr Phe Arg Thr Pro Glu Ile 
1               5                   10                  15  


<210>  94
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  94

Ser Pro Ser Tyr Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser 
1               5                   10                  15  


<210>  95
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  95

Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp 
1               5                   10                  15  


<210>  96
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  96

Arg Lys Leu Gln Pro Ala Ala Met 
1               5               


