                         SEQUENCE LISTING

<110>  Ƽ޹˾
 
<120>  ǶϿԭ弰;Ʊ

<130>  AJFS2016BJ681

<150>  201611129644.6
<151>  2016-12-09

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  1

Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala 
1               5                   10                  15      


Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe 
            20                  25                  30          


Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro 
        35                  40                  45              


Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln 
    50                  55                  60                  


Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg 
65                  70                  75                  80  


Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr 
                85                  90                  95      


Tyr Leu Cys Gly Ala 
            100     


<210>  2
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  2

Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala 
1               5                   10                  15      


Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe 
            20                  25                  30          


Ser Asn Thr Ser Glu Ser Phe His Val Val Trp His Arg Glu Ser Pro 
        35                  40                  45              


Ser Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln 
    50                  55                  60                  


Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg 
65                  70                  75                  80  


Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr 
                85                  90                  95      


Tyr Val Cys Gly Val 
            100     


<210>  3
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  3

Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala 
1               5                   10                  15      


Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe 
            20                  25                  30          


Ser Asn Thr Ser Glu Ser Phe His Val Val Trp His Arg Glu Ser Pro 
        35                  40                  45              


Ser Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln 
    50                  55                  60                  


Pro Gly Gln Asp Ala Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg 
65                  70                  75                  80  


Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr 
                85                  90                  95      


Tyr Val Cys Gly Val 
            100     


<210>  4
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  4

Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu 
1               5                   10                  15      


Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His 
            20                  25                  30  


<210>  5
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  5

Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu 
1               5                   10                  15      


Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Thr Thr 
            20                  25                  30          


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        35                  40                  45              


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    50                  55                  60                  


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
65                  70                  75  


<210>  6
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  6

Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu Ser Leu Arg Ala Glu 
1               5                   10                  15      


Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His 
            20                  25                  30  


<210>  7
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  7

Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
1               5                   10                  15      


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
            20                  25                  30          


Ala Phe Ile Ile Phe Trp Val 
        35                  


<210>  8
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  8

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  9
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  9

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  10
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  10

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu 
        35                  40                  45              


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    50                  55                  60                  


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
65                  70                  75                  80  


Cys Glu Leu 
            


<210>  11
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  11

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  12
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  12

Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala 
1               5                   10                  15      


Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe 
            20                  25                  30          


Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro 
        35                  40                  45              


Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln 
    50                  55                  60                  


Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg 
65                  70                  75                  80  


Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr 
                85                  90                  95      


Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu 
            100                 105                 110         


Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro 
        115                 120                 125             


Thr Ala His Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
    130                 135                 140                 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
145                 150                 155                 160 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
                165                 170                 175     


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
            180                 185                 190         


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
        195                 200                 205             


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    210                 215                 220                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
225                 230                 235                 240 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                245                 250                 255     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            260                 265                 270         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        275                 280                 285             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    290                 295                 300                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
305                 310                 315                 320 


Pro Pro Arg 
            


<210>  13
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  13

Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala 
1               5                   10                  15      


Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe 
            20                  25                  30          


Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro 
        35                  40                  45              


Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln 
    50                  55                  60                  


Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg 
65                  70                  75                  80  


Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr 
                85                  90                  95      


Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu 
            100                 105                 110         


Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro 
        115                 120                 125             


Thr Ala His Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
    130                 135                 140                 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
145                 150                 155                 160 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
                165                 170                 175     


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
            180                 185                 190         


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
        195                 200                 205             


Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
    210                 215                 220                 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
225                 230                 235                 240 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
                245                 250                 255     


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
            260                 265                 270         


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
        275                 280                 285             


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
    290                 295                 300                 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
305                 310                 315                 320 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
                325                 330                 335     


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
            340                 345                 350         


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365 


<210>  14
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  14

Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala 
1               5                   10                  15      


Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe 
            20                  25                  30          


Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro 
        35                  40                  45              


Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln 
    50                  55                  60                  


Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg 
65                  70                  75                  80  


Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr 
                85                  90                  95      


Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu 
            100                 105                 110         


Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro 
        115                 120                 125             


Thr Ala His Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
    130                 135                 140                 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
145                 150                 155                 160 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys 
                165                 170                 175     


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
            180                 185                 190         


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
        195                 200                 205             


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    210                 215                 220                 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
225                 230                 235                 240 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                245                 250                 255     


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            260                 265                 270         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        275                 280                 285             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    290                 295                 300                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
305                 310                 315                 320 


Leu Pro Pro Arg 
                


<210>  15
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  15

Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala 
1               5                   10                  15      


Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe 
            20                  25                  30          


Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro 
        35                  40                  45              


Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln 
    50                  55                  60                  


Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg 
65                  70                  75                  80  


Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr 
                85                  90                  95      


Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu 
            100                 105                 110         


Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro 
        115                 120                 125             


Thr Ala His Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
    130                 135                 140                 


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
145                 150                 155                 160 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
                165                 170                 175     


Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu 
            180                 185                 190         


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
        195                 200                 205             


Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His 
    210                 215                 220                 


Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys 
225                 230                 235                 240 


His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                245                 250                 255     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
            260                 265                 270         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        275                 280                 285             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    290                 295                 300                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
305                 310                 315                 320 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                325                 330                 335     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            340                 345                 350         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        355                 360                 365             


<210>  16
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  16

Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala 
1               5                   10                  15      


Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe 
            20                  25                  30          


Ser Asn Thr Ser Glu Ser Phe His Val Val Trp His Arg Glu Ser Pro 
        35                  40                  45              


Ser Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln 
    50                  55                  60                  


Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg 
65                  70                  75                  80  


Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr 
                85                  90                  95      


Tyr Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu 
            100                 105                 110         


Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro 
        115                 120                 125             


Thr Ala His Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
    130                 135                 140                 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
145                 150                 155                 160 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
                165                 170                 175     


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
            180                 185                 190         


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
        195                 200                 205             


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    210                 215                 220                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
225                 230                 235                 240 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                245                 250                 255     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            260                 265                 270         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        275                 280                 285             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    290                 295                 300                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
305                 310                 315                 320 


Pro Pro Arg 
            


<210>  17
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  17

Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala 
1               5                   10                  15      


Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe 
            20                  25                  30          


Ser Asn Thr Ser Glu Ser Phe His Val Val Trp His Arg Glu Ser Pro 
        35                  40                  45              


Ser Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln 
    50                  55                  60                  


Pro Gly Gln Asp Ala Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg 
65                  70                  75                  80  


Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr 
                85                  90                  95      


Tyr Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys Glu 
            100                 105                 110         


Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro 
        115                 120                 125             


Thr Ala His Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
    130                 135                 140                 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
145                 150                 155                 160 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
                165                 170                 175     


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
            180                 185                 190         


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
        195                 200                 205             


Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    210                 215                 220                 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
225                 230                 235                 240 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                245                 250                 255     


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            260                 265                 270         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        275                 280                 285             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    290                 295                 300                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
305                 310                 315                 320 


Pro Pro Arg 
            


<210>  18
<211>  1044
<212>  DNA
<213>  Homo sapiens


<220>
<221>  sig_peptide
<222>  (1)..(72)

<400>  18
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccactgtcc aagtccccta      480

tttcccggac cttctaagcc cttttgggtg ctggtggtgg ttggtggagt cctggcttgc      540

tatagcttgc tagtaacagt ggcctttatt attttctggg tgaggagtaa gaggagcagg      600

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat      660

taccagccct atgccccacc acgcgacttc gcagcctatc gctccagagt gaagttcagc      720

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat      780

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg      840

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat      900

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg      960

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1020

atgcaggccc tgccccctcg ctaa                                            1044


<210>  19
<211>  1170
<212>  DNA
<213>  Homo sapiens


<220>
<221>  sig_peptide
<222>  (1)..(72)

<400>  19
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccactgtcc aagtccccta      480

tttcccggac cttctaagcc cttttgggtg ctggtggtgg ttggtggagt cctggcttgc      540

tatagcttgc tagtaacagt ggcctttatt attttctggg tgaggagtaa gaggagcagg      600

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat      660

taccagccct atgccccacc acgcgacttc gcagcctatc gctccaaacg gggcagaaag      720

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa      780

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagagtgaag      840

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag      900

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct      960

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1020

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1080

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1140

cttcacatgc aggccctgcc ccctcgctaa                                      1170


<210>  20
<211>  1047
<212>  DNA
<213>  Homo sapiens


<220>
<221>  sig_peptide
<222>  (1)..(72)

<400>  20
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccactgtcc aagtccccta      480

tttcccggac cttctaagcc cttttgggtg ctggtggtgg ttggtggagt cctggcttgc      540

tatagcttgc tagtaacagt ggcctttatt attttctggg tgaaacgggg cagaaagaaa      600

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat      660

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc      720

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc      780

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag      840

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa      900

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag      960

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1020

cacatgcagg ccctgccccc tcgctaa                                         1047


<210>  21
<211>  1179
<212>  DNA
<213>  Homo sapiens


<220>
<221>  sig_peptide
<222>  (1)..(72)

<400>  21
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccacaccac gacgccagcg      480

ccgcgaccac caacaccggc gcccaccatc gcgtcgcagc ccctgtccct gcgcccagag      540

gcgtgccggc cagcggcggg gggcgcagtg cacacgaggg ggctggactt cgcctgtgat      600

tgtccaagtc ccctatttcc cggaccttct aagccctttt gggtgctggt ggtggttggt      660

ggagtcctgg cttgctatag cttgctagta acagtggcct ttattatttt ctgggtgagg      720

agtaagagga gcaggctcct gcacagtgac tacatgaaca tgactccccg ccgccccggg      780

cccacccgca agcattacca gccctatgcc ccaccacgcg acttcgcagc ctatcgctcc      840

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc      900

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      960

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat     1020

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1080

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1140

tacgacgccc ttcacatgca ggccctgccc cctcgctaa                            1179


<210>  22
<211>  1044
<212>  DNA
<213>  Homo sapiens


<220>
<221>  sig_peptide
<222>  (1)..(72)

<400>  22
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcc atgtcgtctg gcatcgcgag agccccagcg ggcagacgga cacactggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacgtatgtg gggtgatctc cctggccccc aagatccaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccactgtcc aagtccccta      480

tttcccggac cttctaagcc cttttgggtg ctggtggtgg ttggtggagt cctggcttgc      540

tatagcttgc tagtaacagt ggcctttatt attttctggg tgaggagtaa gaggagcagg      600

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat      660

taccagccct atgccccacc acgcgacttc gcagcctatc gctccagagt gaagttcagc      720

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat      780

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg      840

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat      900

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg      960

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1020

atgcaggccc tgccccctcg ctaa                                            1044


<210>  23
<211>  1044
<212>  DNA
<213>  Homo sapiens


<220>
<221>  sig_peptide
<222>  (1)..(72)

<400>  23
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcc atgtcgtctg gcatcgcgag agccccagcg ggcagacgga cacactggcc      240

gccttccccg aggaccgcag ccagcccggc caggacgccc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacgtatgtg gggtgatctc cctggccccc aagatccaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccactgtcc aagtccccta      480

tttcccggac cttctaagcc cttttgggtg ctggtggtgg ttggtggagt cctggcttgc      540

tatagcttgc tagtaacagt ggcctttatt attttctggg tgaggagtaa gaggagcagg      600

ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat      660

taccagccct atgccccacc acgcgacttc gcagcctatc gctccagagt gaagttcagc      720

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat      780

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg      840

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat      900

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg      960

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1020

atgcaggccc tgccccctcg ctaa                                            1044


<210>  24
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesis

<400>  24
cggaattcgc caccatgcag atcccacagg c                                      31


<210>  25
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesis

<400>  25
gccactgtta ctagcaagct at                                                22


<210>  26
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesis

<400>  26
atagcttgct agtaacagtg gcctttatta ttttctgggt gaaacggggc agaaagaaa        59


<210>  27
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesis

<400>  27
cgacgcgttt agcgaggggg cagggcctgc                                        30


<210>  28
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesis

<400>  28
gtgggcgccg gtgttggtgg tcgcggcgct ggcgtcgtgg tgtgggctgt gggcacttc        59


<210>  29
<211>  112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesis

<400>  29
catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc       60

agtgcacacg agggggctgg acttcgcctg tgattgtcca agtcccctat tt              112


<210>  30
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesis

<400>  30
gatcttgggg gccagggaga tc                                                22


<210>  31
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesis

<400>  31
ctggccccca agatccagat caaagagagc ctg                                    33


<210>  32
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesis

<400>  32
cagcccggcc aggacgcccg cttccgtgtc aca                                    33


<210>  33
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesis

<400>  33
tgtgacacgg aagcgggcgt cctggccggg ctg                                    33


