                         SEQUENCE LISTING

<110>  Weiner, David
       Patel, Ami
 
<120>  DNA ANTIBODY CONSTRUCTS FOR USE AGAINST EBOLA VIRUS

<130>  206194-0009-00-WO.606971

<150>  US 62/559,422
<151>  2017-09-15

<150>  US 62/504,436
<151>  2017-05-10

<150>  US 62/429,454
<151>  2016-12-02

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMAb-2G4

<400>  1

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Met Gln 
            20                  25                  30          


Pro Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr His 
65                  70                  75                  80  


Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Arg Ser Val Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Gly Ile Tyr Tyr Cys Thr Arg Gly Asn Gly Asn Tyr Arg Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly 
465                 470                 475                 480 


Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
                485                 490                 495     


Pro Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu 
            500                 505                 510         


Trp Ile Ser Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ala 
        515                 520                 525             


Ser Leu Ser Val Ser Val Gly Glu Thr Val Ser Ile Thr Cys Arg Ala 
    530                 535                 540                 


Ser Glu Asn Ile Tyr Ser Ser Leu Ala Trp Tyr Gln Gln Lys Gln Gly 
545                 550                 555                 560 


Lys Ser Pro Gln Leu Leu Val Tyr Ser Ala Thr Ile Leu Ala Asp Gly 
                565                 570                 575     


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser Leu 
            580                 585                 590         


Lys Ile Asn Ser Leu Gln Ser Glu Asp Phe Gly Thr Tyr Tyr Cys Gln 
        595                 600                 605             


His Phe Trp Gly Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
    610                 615                 620                 


Ile Lys Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
625                 630                 635                 640 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
                645                 650                 655     


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
            660                 665                 670         


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
        675                 680                 685             


Ser Thr Tyr Ser Leu Ser Asn Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
    690                 695                 700                 


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
705                 710                 715                 720 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730         


<210>  2
<211>  2202
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGX9226, DMAb-2G4

<400>  2
atggattgga catggaggat tctgtttctg gtcgccgccg caactggaac ccacgctgaa       60

gtgcagctgc aggagtcagg aggaggactg atgcagcccg gcggaagcat gaagctgtcc      120

tgcgtggcat ctggcttcac ctttagtaac tactggatga attgggtccg ccagtcacct      180

gagaagggac tggaatgggt ggctgagatc cgactgaaaa gcaacaatta cgccacccac      240

tatgctgagt cagtgaaggg gcgattcaca attagcaggg acgattctaa aagaagtgtg      300

tatctgcaga tgaacactct gagagccgaa gacaccggaa tctactattg cacacggggc      360

aacggaaatt accgcgctat ggattattgg gggcagggca cttccgtcac cgtgagctcc      420

gcaagcacaa agggaccctc cgtgtttccc ctggcccctt ctagtaaaag cacctccgga      480

ggaacagcag ctctgggatg tctggtgaag gactacttcc ctgagccagt caccgtgtca      540

tggaacagcg gagccctgac ctctggggtc catacatttc ctgctgtgct gcagtcaagc      600

gggctgtact ccctgtcctc tgtggtcact gtgccaagtt caagcctggg cactcagacc      660

tatatctgca acgtgaatca caagcccagc aataccaaag tcgacaagaa agtggagcct      720

aagtcctgtg ataaaacaca tacttgccca ccttgtccag cacctgaact gctgggagga      780

cctagcgtgt tcctgtttcc acccaagcca aaagacacac tgatgatttc ccgcactcct      840

gaggtcacct gtgtggtcgt ggacgtgtct cacgaggacc ccgaagtcaa gttcaactgg      900

tacgtggatg gcgtcgaagt gcataatgcc aagaccaaac ccagggagga acagtacaac      960

tctacctata gggtcgtgag tgtcctgaca gtgctgcacc aggactggct gaacggcaag     1020

gagtataagt gcaaagtgag caataaggct ctgccagcac ccatcgaaaa aactatttcc     1080

aaggccaaag gacagccaag agagccccag gtgtacaccc tgcctccatc tcgggacgaa     1140

ctgacaaaga accaggtcag tctgacttgt ctggtgaaag gcttctatcc atccgatatc     1200

gctgtggagt gggaatctaa tggacagccc gagaacaatt acaagaccac accccctgtg     1260

ctggactccg atgggtcttt ctttctgtat agtaagctga ccgtggataa atcacggtgg     1320

cagcagggca acgtcttttc ttgcagtgtg atgcatgaag ccctgcacaa tcattacaca     1380

cagaagtcac tgagcctgtc cccaggcaag cgaggacgaa aaaggagatc tggaagtggg     1440

gctactaact tcagcctgct gaaacaggca ggcgacgtgg aggaaaatcc tggaccaatg     1500

gtcctgcaga cccaggtgtt tatctcactg ctgctgtgga ttagcggggc ttacggcgat     1560

attcagatga cacagtcccc agcatcactg agcgtctccg tgggagaaac agtgtccatc     1620

acttgtcgcg cctctgagaa catctacagc agcctggctt ggtatcagca gaagcaggga     1680

aaaagccccc agctgctggt ctactccgca acaatcctgg ccgacggggt gccttctagg     1740

ttctctggca gtggatcagg gacacagtat agcctgaaga ttaatagtct gcagtcagag     1800

gattttggga cttactattg ccagcacttc tggggcacac catacacttt tggcggaggg     1860

actaagctgg agatcaaaac cgtcgcagcc ccctctgtgt tcatttttcc acccagtgac     1920

gaacagctga agagtggcac cgcctcagtc gtgtgtctgc tgaacaattt ctaccctaga     1980

gaggcaaagg tccagtggaa agtggataac gccctgcaga gcggcaattc ccaggaatct     2040

gtgactgagc aggacagtaa ggattcaacc tatagcctgt ccaacaccct gacactgagc     2100

aaagctgact acgaaaagca caaagtctat gcatgcgagg tgacacatca gggactgagt     2160

tcaccagtga ctaagtcctt taatcggggg gagtgttgat aa                        2202


<210>  3
<211>  711
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMAb-4G7

<400>  3

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Met Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Phe 
            20                  25                  30          


Ser Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Thr Tyr Tyr Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ala Tyr Tyr Gly Ser Thr Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
    450                 455                 460                 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val 
465                 470                 475                 480 


Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala 
                485                 490                 495     


Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser 
            500                 505                 510         


Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr 
        515                 520                 525             


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu 
    530                 535                 540                 


Leu Val Tyr Asn Ala Lys Thr Leu Ile Glu Gly Val Pro Ser Arg Phe 
545                 550                 555                 560 


Ser Gly Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu 
                565                 570                 575     


Gln Pro Glu Asp Phe Gly Ser Tyr Phe Cys Gln His His Phe Gly Thr 
            580                 585                 590         


Pro Phe Thr Phe Gly Ser Gly Thr Glu Leu Glu Ile Lys Thr Val Ala 
        595                 600                 605             


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
    610                 615                 620                 


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
625                 630                 635                 640 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
                645                 650                 655     


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
            660                 665                 670         


Ser Asn Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
        675                 680                 685             


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
    690                 695                 700                 


Ser Phe Asn Arg Gly Glu Cys 
705                 710     


<210>  4
<211>  2196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGX9229, DMAb-4G7

<400>  4
atggattgga catggaggat tctgtttctg gtcgccgccg ccactggaac ccacgcccag       60

gtgcagctgc agcagtcagg gcctgagctg gaaatgcctg gcgcttctgt gaaaatcagt      120

tgcaaggcat caggaagctc cttcacaggg tttagcatga actgggtgaa acagagcaat      180

gggaagtccc tggagtggat cggcaacatt gacacctact atggcggaac cacatacaat      240

cagaagttca aaggcaaggc tacactgact gtggacaaat ctagttcaac cgcatatatg      300

cagctgaaga gcctgacatc cgaggattct gcagtgtact attgcgctag atcagcatac      360

tatggcagca ctttcgccta ctggggccag ggaaccctgg tcacagtgag ctccgcctcc      420

accaaaggac catctgtgtt tcccctggct ccttctagta agagtacatc aggaggaact      480

gcagctctgg gatgtctggt gaaggattat ttccctgagc cagtcaccgt gagttggaac      540

tcaggcgcac tgacttctgg agtccacacc tttcctgccg tgctgcagtc aagcggcctg      600

tacagcctgt cctctgtggt caccgtgcca agttcaagcc tgggaaccca gacatatatc      660

tgcaacgtga atcacaaacc ctctaataca aaggtcgaca agaaagtgga acctaaaagc      720

tgtgataaga ctcatacctg cccaccttgt ccagcacctg agctgctggg agggccttcc      780

gtgttcctgt ttccacccaa accaaaggac acactgatga ttagcagaac ccctgaagtc      840

acatgtgtgg tcgtggacgt gtcccacgag gaccccgaag tcaagttcaa ctggtacgtg      900

gatggcgtcg aggtgcataa tgctaaaacc aagccccgag aggaacagta caactctact      960

tatagggtcg tgagtgtcct gaccgtgctg caccaggact ggctgaacgg caaggagtat     1020

aaatgcaagg tgtctaacaa ggccctgcca gctcccatcg agaagacaat tagcaaagct     1080

aagggacagc caagagaacc ccaggtgtac actctgcctc catctcggga cgagctgacc     1140

aaaaaccagg tcagtctgac atgtctggtg aagggattct atccaagcga tatcgcagtg     1200

gagtgggaat ccaatgggca gcccgaaaac aattacaaga ctaccccccc tgtgctggac     1260

agcgatggca gcttcttcct gtattccaaa ctgacagtgg ataagtctcg gtggcagcag     1320

gggaacgtct ttagctgctc cgtgatgcat gaggccctgc acaatcatta cactcagaag     1380

tctctgagtc tgtcaccagg caaacgagga cgaaagagga gaagcgggtc cggagcaacc     1440

aacttctccc tgctgaagca ggctggagac gtggaggaaa atcctgggcc aatggtcctg     1500

cagacacagg tgtttatctc actgctgctg tggattagcg gggcctacgg cgatattcag     1560

atgactcaga gccccgcatc tctgagtgcc tcagtcggcg agacagtgac tatcacctgt     1620

cgcgcaagtg aaaacatcta ctcatatctg gcctggtacc agcagaaaca ggggaagagc     1680

ccccagctgc tggtctataa tgctaaaacc ctgatcgaag gagtgccttc ccgattcagc     1740

ggcagcgggt ctggcacaca gtttagcctg aagattaact ccctgcagcc agaggacttc     1800

ggcagctact tttgccagca ccatttcgga actcccttca cctttggcag cgggacagag     1860

ctggaaatca aaactgtcgc agcccccagt gtgttcattt ttccaccctc agacgaacag     1920

ctgaagtctg ggaccgccag tgtcgtgtgt ctgctgaaca atttttaccc tcgggaggct     1980

aaagtccagt ggaaggtgga taacgcactg cagtctggaa atagtcagga gtcagtgaca     2040

gaacaggaca gcaaagattc cacttatagt ctgtcaaaca cactgactct gtctaaggcc     2100

gactacgaga aacacaaggt ctatgcttgc gaagtgactc atcaggggct gtcctctcct     2160

gtgaccaaga gcttcaatcg cggcgagtgt tgataa                               2196


<210>  5
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMAB4

<400>  5

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Leu Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Ser Gly Val Gly Val Gly Trp Phe Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala Leu Ile Trp Trp Asp Asp Asp Lys Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Gln Leu Ser Ile Ser Lys Asp Phe Ser Arg 
                85                  90                  95      


Asn Gln Val Phe Leu Lys Ile Ser Asn Val Asp Ile Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Arg Asp Pro Phe Gly Tyr Asp Asn Ala Met 
        115                 120                 125             


Gly Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser 
465                 470                 475                 480 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
                485                 490                 495     


Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu 
            500                 505                 510         


Leu Trp Ile Ser Gly Ala Tyr Gly Asp Ile Val Met Thr Gln Ser Gln 
        515                 520                 525             


Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Leu Thr Cys Lys 
    530                 535                 540                 


Ala Ser Gln Asn Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro 
545                 550                 555                 560 


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Asn Arg Tyr Thr 
                565                 570                 575     


Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
            580                 585                 590         


Leu Thr Ile Ser Asn Met Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys 
        595                 600                 605             


Gln Gln Tyr Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
    610                 615                 620                 


Glu Ile Lys Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
625                 630                 635                 640 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
                645                 650                 655     


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
            660                 665                 670         


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
        675                 680                 685             


Asp Ser Thr Tyr Ser Leu Ser Asn Thr Leu Thr Leu Ser Lys Ala Asp 
    690                 695                 700                 


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
705                 710                 715                 720 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730             


<210>  6
<211>  2226
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGX9230, DMAb4

<400>  6
ggatccgccg ccaccatgga ctggacttgg agaattctgt tcctggtcgc agcagccact       60

gggacacacg cacaggtgac actgaaagag agcggacccg gaatcctgaa accaagccag      120

actctgtccc tgacctgcag cctgtccggc ttctctctga gtacctcagg agtcggagtg      180

ggatggtttc gacagccaag cggaaaggga ctggagtggc tggccctgat ctggtgggac      240

gatgacaagt actataaccc ttcactgaaa agccagctga gcatttccaa ggatttctct      300

cgcaaccagg tctttctgaa gatcagtaat gtggatattg ccgacactgc tacctactat      360

tgcgctagga gagatccatt cggctacgac aatgcaatgg gatattgggg ccagggaacc      420

tccgtcacag tgagctccgc atccacaaaa gggccctctg tgtttcccct ggccccttct      480

agtaagtcta caagtggcgg aactgccgct ctgggctgtc tggtgaagga ctacttccct      540

gagccagtca ccgtgtcctg gaactctgga gccctgactt ctggggtcca cacctttcct      600

gctgtgctgc agtcaagcgg actgtacagc ctgtcctctg tggtcaccgt gccaagttca      660

agcctgggga cacagactta tatctgcaac gtgaatcaca agccatctaa tacaaaagtc      720

gataagaaag tggaacccaa gagctgtgac aaaacccata catgcccacc ttgtccagca      780

cctgagctgc tgggaggacc aagcgtgttc ctgtttccac ccaagcctaa agatacactg      840

atgatttcca ggacccccga agtgacatgt gtggtcgtgg atgtgtctca cgaggaccct      900

gaagtcaagt tcaactggta cgtggacggc gtcgaggtgc ataatgctaa gaccaaacct      960

cgcgaggaac agtacaacag tacatatcga gtcgtgtcag tgctgaccgt cctgcaccag     1020

gactggctga acggaaagga gtataagtgc aaagtgagca acaaggcact gccagccccc     1080

atcgagaaga ctatttccaa ggcaaaaggg cagccaaggg aaccccaggt gtacaccctg     1140

cctccaagca gagatgagct gactaaaaac caggtctccc tgacctgtct ggtgaagggg     1200

ttctatccta gtgacatcgc tgtggagtgg gaatcaaatg gccagccaga aaacaattac     1260

aagaccacac cccctgtgct ggatagtgac ggctcattct ttctgtattc aaagctgacc     1320

gtggataaaa gcagatggca gcagggaaac gtcttctcat gcagcgtgat gcatgaggcc     1380

ctgcacaatc attacactca gaaatccctg tctctgagtc ccggcaagcg aggaaggaaa     1440

cggcgctcag ggagcggcgc tacaaacttt tccctgctga agcaggcagg ggacgtggag     1500

gaaaatcctg gcccaatggt cctgcagacc caggtgttca tcagcctgct gctgtggatt     1560

tccggggcct acggcgatat tgtgatgacc cagagccaga agttcatgtc cacatctgtc     1620

ggcgaccggg tgtctctgac ctgtaaggcc agtcagaacg tcggaactgc tgtggcatgg     1680

tatcagcaga agcctgggca gtccccaaaa ctgctgatct acagtgcttc aaacagatat     1740

accggcgtgc ctgatcggtt caccggaagc gggtccggca cagactttac tctgaccatt     1800

tctaatatgc agagtgaaga tctggctgac tacttctgcc agcagtactc ctcttatcca     1860

ctgacatttg gagcagggac taagctggaa atcaaaacag tcgcagcccc ctccgtgttc     1920

atttttccac cctctgatga gcagctgaag tcaggcactg ccagcgtcgt gtgtctgctg     1980

aacaatttct accccaggga ggccaaggtc cagtggaaag tggacaacgc tctgcagagc     2040

ggaaattccc aggagtctgt gactgaacag gatagtaaag actcaaccta ttctctgagt     2100

aacacactga ctctgtccaa ggcagactac gagaagcaca aagtctatgc ctgcgaagtg     2160

acccatcagg gcctgagttc accagtgaca aagtctttta atcgcggaga gtgttgataa     2220

ctcgag                                                                2226


<210>  7
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMAb-10

<400>  7

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Arg Ser Tyr Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Gly 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Val Arg Phe Gly Asp Thr Ala Val Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn 
465                 470                 475                 480 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                485                 490                 495     


Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
            500                 505                 510         


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
        515                 520                 525             


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
    530                 535                 540                 


Ile Ser Ser Phe Leu Asn Trp His Gln Gln Lys Pro Gly Lys Ala Pro 
545                 550                 555                 560 


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
                565                 570                 575     


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
            580                 585                 590         


Ser Leu Gln Pro Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Ser Tyr 
        595                 600                 605             


Ile Ser Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Thr 
    610                 615                 620                 


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
625                 630                 635                 640 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
                645                 650                 655     


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
            660                 665                 670         


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
        675                 680                 685             


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
    690                 695                 700                 


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
705                 710                 715                 720 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 


<210>  8
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGX9244, DMAb-10

<400>  8
ggatccgccg ccaccatgga ctggacttgg agaatcctgt tcctggtcgc cgccgctact       60

gggactcatg ccgaggtgca gctggtcgaa tctggagggg gcctggtgca gcctggcggc      120

agcctgaggc tgtcctgcgc agcatctggc ttcaccttta ggagctacga catgcactgg      180

gtgcgccagg caacaggcaa gggactggag tgggtgtctg ccatcggaac cgcaggcgat      240

acatactatc caggctccgt gaagggcagg ttcaccatct cccgcgagaa cgccaagaat      300

tctctgtacc tgcagatgaa cagcctgaga gccgaggaca ccgccgtgta ctattgcgcc      360

agggtgcgct tcggcgacac agcagtggat tattggggcc agggcaccct ggtgacagtg      420

agctccgcct ccaccaaggg accaagcgtg ttcccactgg caccttctag caagtccacc      480

tctggcggca cagccgccct gggctgtctg gtgaaggatt acttccctga gccagtgaca      540

gtgtcctgga actctggcgc cctgaccagc ggagtgcaca catttcctgc cgtgctgcag      600

tcctctggcc tgtactccct gagctccgtg gtgaccgtgc catctagctc cctgggcacc      660

cagacatata tctgcaacgt gaatcacaag cctagcaata caaaggtgga caagaaggtg      720

gagccaaagt cctgtgataa gacccacaca tgccctccct gtccagcacc tgagctgctg      780

ggcggcccaa gcgtgttcct gtttccaccc aagcccaagg acaccctgat gatcagccgg      840

accccagagg tgacatgcgt ggtggtggac gtgtcccacg aggaccccga ggtgaagttt      900

aactggtacg tggatggcgt ggaggtgcac aatgccaaga ccaagccccg ggaggagcag      960

tacaacagca cctatagagt ggtgtccgtg ctgacagtgc tgcaccagga ctggctgaac     1020

ggcaaggagt ataagtgcaa ggtgagcaat aaggccctgc cagcccccat cgagaagacc     1080

atctccaagg caaagggaca gccaagggag ccacaggtgt acacactgcc tccatcccgc     1140

gacgagctga ccaagaacca ggtgtctctg acatgtctgg tgaagggctt ctatccctct     1200

gatatcgccg tggagtggga gagcaatggc cagcctgaga acaattacaa gaccacaccc     1260

cctgtgctgg acagcgatgg ctccttcttt ctgtattcca agctgaccgt ggacaagtct     1320

cggtggcagc agggcaacgt gtttagctgc tccgtgatgc acgaggccct gcacaatcac     1380

tacacccaga agtctctgag cctgtcccca ggcaagaggg gaagaaagcg gagatctggc     1440

agcggcgcca caaacttcag cctgctgaag caggccggcg atgtggagga gaatcctggc     1500

ccaatggtgc tgcagaccca ggtgtttatc tctctgctgc tgtggatcag cggcgcctat     1560

ggcgacatcc agatgacaca gtccccttct agcctgtccg cctctgtggg cgatcgggtg     1620

accatcacat gtagagccag ccagtccatc tcctctttcc tgaactggca ccagcagaag     1680

cctggcaagg ccccaaagct gctgatctac gcagccagct ccctgcagag cggagtgccc     1740

tccaggttct ctggcagcgg ctccggaacc gactttaccc tgacaatctc tagcctgcag     1800

cctgaggatt ttgccatcta ctattgccag cagtcttata tcagcccctt cacctttggc     1860

cctggcacaa aggtggacat caagaccgtg gccgccccaa gcgtgttcat ctttccaccc     1920

tccgatgagc agctgaagtc tggcacagcc agcgtggtgt gcctgctgaa caatttctac     1980

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caattctcag     2040

gagagcgtga ccgagcagga ctccaaggat tctacatatt ctctgagctc taccctgaca     2100

ctgagcaagg ccgattacga gaagcacaag gtgtatgcct gcgaggtcac ccaccagggg     2160

ctgtcaagtc cagtcactaa gtccttcaat cggggcgaat gctgataact cgag           2214


<210>  9
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMAb-11

<400>  9

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Val 
        35                  40                  45              


Arg Ser Asn Tyr Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Leu Ile Tyr Ser Gly Gly Leu Thr Ala Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Val Ala Ser Ser Ala Gly Thr Phe Tyr Tyr Gly Met 
        115                 120                 125             


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser 
465                 470                 475                 480 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
                485                 490                 495     


Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu 
            500                 505                 510         


Leu Trp Ile Ser Gly Ala Tyr Gly Asp Ile Val Met Thr Gln Ser Pro 
        515                 520                 525             


Arg Ser Leu Ser Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg 
    530                 535                 540                 


Ser Ser Gln Ser Leu Leu His Arg Asn Gly Tyr Asn Tyr Leu Asp Trp 
545                 550                 555                 560 


Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly 
                565                 570                 575     


Ser Asn Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
            580                 585                 590         


Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val 
        595                 600                 605             


Gly Val Tyr Tyr Cys Met Gln Ala Leu Gln Thr Pro Ser Trp Thr Phe 
    610                 615                 620                 


Gly Gln Gly Thr Lys Val Glu Ile Lys Thr Val Ala Ala Pro Ser Val 
625                 630                 635                 640 


Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
                645                 650                 655     


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
            660                 665                 670         


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
        675                 680                 685             


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
    690                 695                 700                 


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
705                 710                 715                 720 


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
                725                 730                 735     


Gly Glu Cys 
            


<210>  10
<211>  2244
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGX9256, DMAb-11

<400>  10
ggatccgccg ccaccatgga ctggacctgg agaatcctgt tcctggtggc agcagcaacc       60

ggaacacacg cagaggtgca gctggtggag agcggcggcg gcctgatcca gccaggcggc      120

agcctgaggc tgtcctgcgc agcatctgga tttgccgtga ggagcaacta cctgtcctgg      180

gtgagacagg caccaggcaa gggactggag tgggtgtctc tgatctacag cggcggcctg      240

accgcatatg cagacagcgt ggagggcagg ttcaccatct ccagagataa ctctaagaat      300

acactgtatc tgcagatgaa ttccctgcgg gtggaggaca ccgccctgta ctattgcgcc      360

cgcgtggcca gctccgccgg cacattctac tatggcatgg acgtgtgggg ccagggcacc      420

acagtgaccg tgtctagcgc ctccacaaag ggaccaagcg tgttcccact ggcaccttcc      480

tctaagtcca cctctggcgg cacagccgcc ctgggctgtc tggtgaagga ttacttccct      540

gagccagtga ccgtgtcttg gaacagcggc gccctgacca gcggagtgca cacatttcct      600

gccgtgctgc agagctccgg cctgtactcc ctgtctagcg tggtgaccgt gccatcctct      660

agcctgggca cccagacata tatctgcaac gtgaatcaca agcctagcaa tacaaaggtg      720

gacaagaagg tggagccaaa gtcctgtgat aagacccaca catgccctcc ctgtccagca      780

cctgagctgc tgggcggccc aagcgtgttc ctgtttccac ccaagcccaa ggacacactg      840

atgatctcta ggaccccaga ggtgacatgc gtggtggtgg acgtgagcca cgaggacccc      900

gaggtgaagt ttaactggta cgtggatggc gtggaggtgc acaatgccaa gaccaagcca      960

agggaggagc agtacaacag cacctataga gtggtgtccg tgctgacagt gctgcaccag     1020

gactggctga acggcaagga gtataagtgc aaggtgtcca ataaggccct gccagccccc     1080

atcgagaaga ccatctctaa ggcaaaggga cagccaaggg agccacaggt gtacacactg     1140

cctccatcca gagacgagct gaccaagaac caggtgtctc tgacatgtct ggtgaagggc     1200

ttctatccct ctgatatcgc cgtggagtgg gagagcaatg gccagcctga gaacaattac     1260

aagaccacac cccctgtgct ggactccgat ggctctttct ttctgtattc caagctgacc     1320

gtggataagt ctcggtggca gcagggcaac gtgtttagct gctccgtgat gcacgaggcc     1380

ctgcacaatc actacaccca gaagtctctg agcctgtccc ctggcaagag gggaaggaag     1440

aggagatctg gcagcggcgc cacaaacttc agcctgctga agcaggcagg cgacgtggag     1500

gagaatcctg gaccaatggt gctgcagacc caggtgttta tctctctgct gctgtggatc     1560

agcggcgcct acggcgatat cgtgatgacc cagtcccctc gctccctgtc tgtgacacct     1620

ggcgagccag ccagcatctc ctgtcggtcc tctcagtctc tgctgcaccg caacggctac     1680

aattatctgg actggtacct gcagaagccc ggccagtccc ctcagctgct gatctatctg     1740

ggcagcaaca gggcatccgg agtgccagac cgcttctctg gcagcggctc cggaaccgac     1800

ttcaccctga agatcagcag ggtggaggcc gaggatgtgg gcgtgtacta ttgcatgcag     1860

gccctgcaga ccccctcctg gacattcggc cagggcacca aggtggagat caagacagtg     1920

gccgccccta gcgtgttcat ctttccaccc tccgacgagc agctgaagtc tggcaccgcc     1980

agcgtggtgt gcctgctgaa caacttctac cccagagagg ccaaggtgca gtggaaggtg     2040

gataacgccc tgcagagcgg caattcccag gagtctgtga ccgagcagga cagcaaggat     2100

tccacatatt ctctgagctc caccctgaca ctgagcaagg ccgactacga gaagcacaag     2160

gtgtatgcct gcgaggtgac ccaccagggc ctgtctagcc ctgtgacaaa gtccttcaac     2220

agaggcgagt gttgataact cgag                                            2244


<210>  11
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMAb12

<400>  11

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ala Thr Phe 
        35                  40                  45              


Gly Ser Asp Thr Val Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gly Ile Ile Pro Phe Phe Gly Glu Ala Asn Tyr Ala 
65                  70                  75                  80  


Gln Arg Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gln Ile Asn Glu Met Ala Thr Phe Gly Glu Ile 
        115                 120                 125             


His Tyr Tyr Thr Tyr Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg 
465                 470                 475                 480 


Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
                485                 490                 495     


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln 
            500                 505                 510         


Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Gly Ser 
        515                 520                 525             


Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val 
    530                 535                 540                 


Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Asn Tyr Tyr Ala Ser Trp 
545                 550                 555                 560 


Tyr Gln Gln Lys Pro Arg Gln Ala Pro Val Leu Val Phe Tyr Gly Lys 
                565                 570                 575     


Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser 
            580                 585                 590         


Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Ala Gln Ala Glu Asp Glu 
        595                 600                 605             


Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Ser Asn His Leu Val 
    610                 615                 620                 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Thr Val Ala Ala Pro 
625                 630                 635                 640 


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
                645                 650                 655     


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
            660                 665                 670         


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
        675                 680                 685             


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Asn 
    690                 695                 700                 


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
705                 710                 715                 720 


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
                725                 730                 735     


Asn Arg Gly Glu Cys 
            740     


<210>  12
<211>  2232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGX9260, DMAb12

<400>  12
catggactgg acctggagaa tcctgttcct ggtggcagca gcaaccggaa cacacgcaca       60

ggtgcagctg gtgcagagcg gagcagaggt gaagaagcca ggcagctccg tgaaggtgtc      120

ctgcaaggca tctggagcca ccttcggctc cgataccgtg acatgggtgc gccaggcacc      180

aggacaggga ctggagtgga tgggcggcat catccctttc tttggcgagg ccaactacgc      240

ccagcggttt cagggcagag tgaccatcac agccgacaag tccaccaata cagcctacat      300

ggagctgtct agcctgcggt ctgaggatac cgccgtgtat ttctgcgcca gacagatcaa      360

cgagatggcc acctttggcg agatccacta ctatacatac atggacgtgt ggggacaggg      420

caccctggtg acagtgtcct ctgcctccac caagggacct agcgtgttcc cactggcacc      480

tagctccaag tctaccagcg gcggcacagc cgccctggga tgtctggtga aggattattt      540

ccctgagcca gtgacagtgt cctggaactc tggcgccctg accagcggag tgcacacatt      600

tcccgccgtg ctgcagtcta gcggcctgta ctccctgtcc tctgtggtga ccgtgcctag      660

ctcctctctg ggcacccaga catatatctg caacgtgaat cacaagcctt ctaatacaaa      720

ggtggacaag aaggtggagc caaagagctg tgataagacc cacacatgcc ctccctgtcc      780

agcacctgag ctgctgggcg gcccaagcgt gttcctgttt ccacccaagc ccaaggacac      840

cctgatgatc agcaggaccc ctgaggtgac atgcgtggtg gtggacgtgt cccacgagga      900

ccccgaggtg aagttcaact ggtacgtgga tggcgtggag gtgcacaatg ccaagaccaa      960

gccccgggag gagcagtaca acagcaccta tagagtggtg tccgtgctga cagtgctgca     1020

ccaggactgg ctgaacggca aggagtataa gtgcaaggtg tctaataagg ccctgccagc     1080

ccccatcgag aagaccatct ccaaggcaaa gggacagcca agggagccac aggtgtacac     1140

actgcctcca agccgcgacg agctgaccaa gaaccaggtg tccctgacat gtctggtgaa     1200

gggcttctat ccatccgata tcgccgtgga gtgggagtct aatggccagc ccgagaacaa     1260

ttacaagacc acaccccctg tgctggacag cgatggctcc ttctttctgt attccaagct     1320

gaccgtggac aagtctcggt ggcagcaggg caacgtgttt tcctgctctg tgatgcacga     1380

ggccctgcac aatcactaca cccagaagag cctgtccctg tctcctggca agaggggaag     1440

gaagcggaga agcggctccg gagccacaaa cttcagcctg ctgaagcagg ccggcgatgt     1500

ggaggagaat cctggcccaa tggtgctgca gacccaggtg tttatctctc tgctgctgtg     1560

gatcagcgga gcatacggcg gctccgagct gacacaggac ccagccgtga gcgtggccct     1620

gggacagacc gtgaggatca catgtcaggg cgatagcctg cgcaactact atgcctcctg     1680

gtaccagcag aagcctcggc aggccccagt gctggtgttc tatggcaaga acaataggcc     1740

ctctggcatc cctgaccgct ttagcggcag ctcctctggc aataccgcaa gcctgacaat     1800

ctccggagca caggcagagg acgaggcaga ttactattgc aacagcagag atagctcctc     1860

taatcacctg gtgttcggcg gcggaaccaa gctgacagtg ctgtctaccg tggccgcccc     1920

aagcgtgttc atctttccac cctccgacga gcagctgaag tctggcacag ccagcgtggt     1980

gtgcctgctg aacaacttct acccccggga ggccaaggtg cagtggaagg tggataacgc     2040

cctgcagtct ggcaatagcc aggagtccgt gaccgagcag gactctaagg atagcacata     2100

ttctctgagc aacaccctga cactgagcaa ggccgactac gagaagcaca aggtgtatgc     2160

atgcgaggtg acccaccagg gactgagctc cccagtgaca aagtccttca atagaggcga     2220

gtgttgataa ct                                                         2232


<210>  13
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMAb13

<400>  13

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Glu Val Ser Gly Leu Thr Phe 
        35                  40                  45              


Ser Asn Phe Gly Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Phe Ile Arg Phe Asp Gly Ser Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Gly Arg Val Leu Tyr Gly Ala Ala Ala Asp Phe Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn 
465                 470                 475                 480 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                485                 490                 495     


Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
            500                 505                 510         


Gly Ala Tyr Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
        515                 520                 525             


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Thr Ser Ser His Ser 
    530                 535                 540                 


Leu Leu Tyr Ser Ser Asp Asn Lys Asn Tyr Leu Thr Trp Tyr Gln Gln 
545                 550                 555                 560 


Lys Ala Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
                565                 570                 575     


Gln Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu 
            580                 585                 590         


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
        595                 600                 605             


Tyr Cys Gln Gln Tyr Tyr Thr Lys Ser Phe Thr Phe Gly Gln Gly Thr 
    610                 615                 620                 


Lys Val Glu Ile Lys Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
625                 630                 635                 640 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
                645                 650                 655     


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
            660                 665                 670         


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
        675                 680                 685             


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Asn Thr Leu Thr Leu Ser Lys 
    690                 695                 700                 


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
705                 710                 715                 720 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730                 735 


<210>  14
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGX9261, DMAb13

<400>  14
catggactgg acctggagaa tcctgttcct ggtggcagca gcaaccggaa cacacgcaca       60

ggtgcagctg gtggagagcg gcggcggcgt ggtgcagcct ggcggctctc tgagactgag      120

ctgcgaggtg tccggcctga ccttcagcaa ctttggaatg cagtgggtga ggcaggcacc      180

aggcaaggga ctggagtggg tggccttcat ccgctttgac ggctctaata agtactatgc      240

cgatagcgtg aagggccggt tcaccatctc tagagacaac agcaagaata cagtgtacct      300

gcagatgggc agcctgaggg cagaggacac cgccgtgtac ttctgcggac gcgtgctgta      360

tggagcagca gcagattttt ggggacaggg caccctggtg acagtgagct ccgcctctac      420

aaagggacca agcgtgtttc cactggcacc ctctagcaag tccacctctg gcggcacagc      480

cgccctgggc tgtctggtga aggattactt ccccgagcct gtgaccgtga gctggaactc      540

cggcgccctg acctccggag tgcacacatt tccagccgtg ctgcagtcct ctggcctgta      600

cagcctgagc tccgtggtga ccgtgccctc tagctccctg ggcacccaga catatatctg      660

caacgtgaat cacaagccaa gcaatacaaa ggtggacaag aaggtggagc ccaagtcctg      720

tgataagacc cacacatgcc ctccctgtcc agcaccagag ctgctgggcg gcccaagcgt      780

gttcctgttt ccacccaagc ctaaggacac cctgatgatc tctagaaccc ccgaggtgac      840

atgcgtggtg gtggacgtga gccacgagga ccccgaggtg aagttcaact ggtacgtgga      900

tggcgtggag gtgcacaatg ccaagacaaa gcctcgggag gagcagtaca actccaccta      960

tagagtggtg tctgtgctga cagtgctgca ccaggactgg ctgaacggca aggagtataa     1020

gtgcaaggtg tccaataagg ccctgcctgc cccaatcgag aagaccatct ctaaggcaaa     1080

gggacagcct cgggagccac aggtgtacac actgcctcca tccagagacg agctgaccaa     1140

gaaccaggtg tctctgacat gtctggtgaa gggcttctat ccttctgata tcgccgtgga     1200

gtgggagagc aatggccagc cagagaacaa ttacaagacc acaccccctg tgctggactc     1260

tgatggcagc ttctttctgt attccaagct gaccgtggac aagtctcggt ggcagcaggg     1320

caacgtgttt agctgctccg tgatgcacga ggccctgcac aatcactaca cccagaagtc     1380

tctgagcctg tccccaggca agaggggaag gaagcggaga tctggcagcg gagccacaaa     1440

cttctccctg ctgaagcagg caggcgatgt ggaggagaat ccaggaccta tggtgctgca     1500

gacccaggtg tttatcagcc tgctgctgtg gatctccggc gcctatggcg acatcgtgat     1560

gacacagtcc ccagattctc tggccgtgtc cctgggagag agggcaacca tcaactgtac     1620

atctagccac agcctgctgt actcctctga caacaagaat tacctgacct ggtatcagca     1680

gaaggccggc cagccaccca agctgctgat ctattgggca tccaccaggc agtctggagt     1740

gccagaccgc ttctccggct ctggcagcgg cacagagttt accctgacaa tcagctccct     1800

gcaggccgag gatgtggccg tgtactattg ccagcagtac tataccaaga gcttcacatt     1860

tggccagggc accaaggtgg agatcaagac agtggccgcc cccagcgtgt tcatctttcc     1920

tccatccgac gagcagctga agagcggaac cgcatccgtg gtgtgcctgc tgaacaattt     1980

ctaccctagg gaggccaagg tgcagtggaa ggtggataac gccctgcaga gcggcaattc     2040

ccaggagtct gtgaccgagc aggacagcaa ggattccaca tattccctgt ctaacaccct     2100

gacactgtcc aaggccgatt acgagaagca caaggtgtat gcctgcgagg tgacccacca     2160

gggcctgtct agccctgtga caaagagctt taatcgcggc gagtgttgat aact           2214


<210>  15
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMAb-34 Heavy Chain

<400>  15

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Ser Ser Tyr Gly Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly Tyr Thr Lys Tyr Ala 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Arg 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Ala Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Leu Thr Pro Arg Asp Gly Met Asp Val Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  16
<211>  1431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMAb-34 Heavy Chain

<400>  16
ggatccgccg ccaccatgga ctggacatgg agaatcctgt tcctggtggc agcagcaacc       60

ggaacacacg cacaggtgca gctggtgcag tccggagcag aggtgaagaa gccaggagcc      120

tctgtgaagg tgagctgcaa ggcctccggc tataccttca gctcctacgg cttttcttgg      180

gtgcgccagg cacctggaca gggcctggag tggatgggct ggatcagcgc ctacaacggc      240

tatacaaagt acgcccagaa gttccagggc cgggtgacca tgaccacaga caccagcaca      300

cgcaccgcct atatggagct gaggagcctg agaagcgacg atgccgccgt gtactattgc      360

gcccgggatc tgacccctcg cgacggaatg gacgtgtggg gacagggaac cacagtgaca      420

gtgtctagcg cctctaccaa gggcccaagc gtgtttccac tggccccctc ctctaagtcc      480

acatctggcg gcaccgccgc cctgggatgt ctggtgaagg attacttccc agagcccgtg      540

accgtgtcct ggaactctgg cgccctgaca agcggcgtgc acacctttcc agccgtgctg      600

cagagctccg gcctgtattc cctgtctagc gtggtgacag tgccctcctc tagcctgggc      660

acacagacct acatctgcaa cgtgaatcac aagccaagca ataccaaggt ggacaagaag      720

gtggagccca agtcctgtga taagacacac acctgccctc cctgtcctgc accagagctg      780

ctgggcggcc catccgtgtt cctgtttcca cccaagccta aggacacact gatgatctct      840

aggacacccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc cgaggtgaag      900

tttaactggt acgtggatgg cgtggaggtg cacaatgcca agaccaagcc aagggaggag      960

cagtataatt ccacatacag agtggtgtct gtgctgaccg tgctgcacca ggactggctg     1020

aacggcaagg agtacaagtg caaggtgtcc aataaggccc tgcccgcccc tatcgagaag     1080

acaatctcta aggccaaggg ccagcctagg gagccacagg tgtataccct gcctccatcc     1140

agagacgagc tgacaaagaa ccaggtgtct ctgacctgtc tggtgaaggg cttctaccct     1200

tctgatatcg ccgtggagtg ggagagcaat ggccagccag agaacaatta taagaccaca     1260

ccccctgtgc tggacagcga tggctccttc tttctgtaca gcaagctgac agtggataag     1320

tccagatggc agcagggcaa cgtgtttagc tgttccgtga tgcacgaggc cctgcacaat     1380

cactacaccc agaagtctct gagcctgtcc cctggcaagt gataactcga g              1431


<210>  17
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMAb-34 Light Chain

<400>  17

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Gln Val Leu Ile Ser Leu Gly Ser Asn Arg Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln Ala Leu Gln Thr Pro Arg Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210>  18
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMAb-34 Light Chain

<400>  18
ggatccgccg ccaccatggt gctgcagacc caggtgttca tctccctgct gctgtggatc       60

tctggcgcct acggcgacat cgtgctgacc cagtctcctc tgagcctgcc tgtgacacca      120

ggagagccag caagcatctc ctgcaggagc tcccagagcc tgctgcactc caacggctac      180

aattatctgg attggtatct gcagaagcca ggacagcccc ctcaggtgct gatctccctg      240

ggctctaaca gggcctctgg cgtgcctgac agattctctg gcagcggctc cggaaccgac      300

ttcaccctga agatcagccg ggtggaggca gaggacgtgg gcgtgtacta ttgcatgcag      360

gccctgcaga cccctcgcac attcggccag ggcaccaagg tggagatcaa gacagtggcc      420

gccccaagcg tgttcatctt tccaccctcc gacgagcagc tgaagtctgg cacagccagc      480

gtggtgtgcc tgctgaacaa cttctaccca agggaggcca aggtgcagtg gaaggtggat      540

aacgccctgc agagcggcaa ttcccaggag tctgtgaccg agcaggacag caaggattcc      600

acatattctc tgtctagcac cctgacactg tccaaggccg attacgagaa gcacaaggtg      660

tatgcatgcg aggtgaccca ccagggcctg tcctctcccg tgacaaagag ctttaatcgg      720

ggcgagtgtt gataactcga g                                                741


<210>  19
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMAb-4G7 heavy chain

<400>  19

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Met Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Phe 
            20                  25                  30          


Ser Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Thr Tyr Tyr Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ala Tyr Tyr Gly Ser Thr Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  20
<211>  416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMAb-4G7 heavy chain

<400>  20
atggattgga catggaggat tctgtttctg gtcgccgccg ccactggaac ccacgcccag       60

gtgcagctgc agcagtcagg gcctgagctg gaaatgcctg gcgcttctgt gaaaatcagt      120

tgcaaggcat caggaagctc cttcacaggg tttagcatga actgggtgaa acagagcaat      180

gggaagtccc tggagtggat cggcaacatt gacacctact atggcggaac cacatacaat      240

cagaagttca aaggcaaggc tacactgact gtggacaaat ctagttcaac cgcatatatg      300

cagctgaaga gcctgacatc cgaggattct gcagtgtact attgcgctag atcagcatac      360

tatggcagca ctttcgccta ctggggccag ggaaccctgg tcacagtgag ctccgc          416


<210>  21
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMAb-4G7 light chain

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ile Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Phe Cys Gln His His Phe Gly Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Glu Leu Glu Ile Lys 
            100                 105         


<210>  22
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMAb-4G7 light chain

<400>  22
gatattcaga tgactcagag ccccgcatct ctgagtgcct cagtcggcga gacagtgact       60

atcacctgtc gcgcaagtga aaacatctac tcatatctgg cctggtacca gcagaaacag      120

gggaagagcc cccagctgct ggtctataat gctaaaaccc tgatcgaagg agtgccttcc      180

cgattcagcg gcagcgggtc tggcacacag tttagcctga agattaactc cctgcagcca      240

gaggacttcg gcagctactt ttgccagcac catttcggaa ctcccttcac ctttggcagc      300

gggacagagc tggaaatcaa aactgtcgca gcccccagtg tgttcatttt tccaccctca      360

gacgaacagc tgaagtctgg gaccgccagt gtcgtgtgtc tgctgaacaa tttttaccct      420

cgggaggcta aagtccagtg gaaggtggat aacgcactgc agtctggaaa tagtcaggag      480

tcagtgacag aacaggacag caaagattcc acttatagtc tgtcaaacac actgactctg      540

tctaaggccg actacgagaa acacaaggtc tatgcttgcg aagtgactca tcaggggctg      600

tcctctcctg tgaccaagag cttcaatcgc ggcgagtgt                             639


<210>  23
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMAb-4 heavy chain

<400>  23

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Leu Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Ser Gly Val Gly Val Gly Trp Phe Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala Leu Ile Trp Trp Asp Asp Asp Lys Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Gln Leu Ser Ile Ser Lys Asp Phe Ser Arg 
                85                  90                  95      


Asn Gln Val Phe Leu Lys Ile Ser Asn Val Asp Ile Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Arg Asp Pro Phe Gly Tyr Asp Asn Ala Met 
        115                 120                 125             


Gly Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140     


<210>  24
<211>  425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMAb-4 heavy chain

<400>  24
atggactgga cttggagaat tctgttcctg gtcgcagcag ccactgggac acacgcacag       60

gtgacactga aagagagcgg acccggaatc ctgaaaccaa gccagactct gtccctgacc      120

tgcagcctgt ccggcttctc tctgagtacc tcaggagtcg gagtgggatg gtttcgacag      180

ccaagcggaa agggactgga gtggctggcc ctgatctggt gggacgatga caagtactat      240

aacccttcac tgaaaagcca gctgagcatt tccaaggatt tctctcgcaa ccaggtcttt      300

ctgaagatca gtaatgtgga tattgccgac actgctacct actattgcgc taggagagat      360

ccattcggct acgacaatgc aatgggatat tggggccagg gaacctccgt cacagtgagc      420

tccgc                                                                  425


<210>  25
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMAb-4 light chain

<400>  25

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  26
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DMAb-4 light chain

<400>  26
gatattgtga tgacccagag ccagaagttc atgtccacat ctgtcggcga ccgggtgtct       60

ctgacctgta aggccagtca gaacgtcgga actgctgtgg catggtatca gcagaagcct      120

gggcagtccc caaaactgct gatctacagt gcttcaaaca gatataccgg cgtgcctgat      180

cggttcaccg gaagcgggtc cggcacagac tttactctga ccatttctaa tatgcagagt      240

gaagatctgg ctgactactt ctgccagcag tactcctctt atccactgac atttggagca      300

gggactaagc tggaaatcaa aacagtcgca gccccctccg tgttcatttt tccaccctct      360

gatgagcagc tgaagtcagg cactgccagc gtcgtgtgtc tgctgaacaa tttctacccc      420

agggaggcca aggtccagtg gaaagtggac aacgctctgc agagcggaaa ttcccaggag      480

tctgtgactg aacaggatag taaagactca acctattctc tgagtaacac actgactctg      540

tccaaggcag actacgagaa gcacaaagtc tatgcctgcg aagtgaccca tcagggcctg      600

agttcaccag tgacaaagtc ttttaatcgc ggagagtgt                             639


