                         SEQUENCE LISTING

<110>  Elliot, Sarah
       Patel, Ami
       Weiner, David B.
 
<120>  MARBURGVIRUS CONSENSUS ANTIGENS, NUCLEIC ACID CONSTRUCTS AND 
       VACCINES MADE THEREFROM, AND METHODS OF USING SAME

<130>  206194-0010-00-WO.606970

<150>  US 62/429,473
<151>  2016-12-02

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  2040
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of Con 1

<400>  1
aagaccacat gcctgttcat cagcctgatc ctgatccagg gcgtgaagac cctgccaatc       60

ctggagatcg cctccaacaa tcagccccag aacgtggaca gcgtgtgctc tggcaccctg      120

cagaagacag aggatgtgca cctgatgggc ttcacactga gcggacagaa ggtggcagac      180

tccccactgg aggcctctaa gaggtgggcc tttagaaccg gcgtgccccc taagaacgtg      240

gagtacaccg agggcgagga ggccaagaca tgctataata tctccgtgac cgatcccagc      300

ggcaagtccc tgctgctgga cccacccaca aacatcaggg attaccctaa gtgtaagacc      360

atccaccaca tccagggcca gaatccacac gcacagggaa tcgccctgca cctgtggggc      420

gccttctttc tgtacgacag gatcgccagc accacaatgt atagaggcaa ggtgttcaca      480

gagggcaaca tcgccgccat gatcgtgaat aagaccgtgc acaagatgat cttttctagg      540

cagggccagg gctacagaca catgaacctg acaagcacca ataagtattg gacaagctcc      600

aacggcacac agaccaatga caccggatgc ttcggcgccc tgcaggagta caactccacc      660

aagaatcaga catgtgcccc atctaagatc cctctgccac tgccaacagc aaggccagag      720

gtgaagctga catctaccag cacagacgcc accaagctga acaccacaga ccccaattcc      780

gacgatgagg atctgaccac atccggctct ggcagcggag agcaggagcc ttataccaca      840

tctgatgccg ccaccaagca gggcctgtct agcaccatgc ctccaacacc tagcccacag      900

ccctccacac ctcagcagga gggcaacaat accaaccact ctcagggagc agtgaccgag      960

cctggcaaga caaacaccac agcccagcca agcatgcccc ctcacaatac cacagccatc     1020

agcaccaaca atacatccaa gcacaacttt tctaccccta gcgtgccact gcagaatgcc     1080

accaactaca atacacagtc caccgccaca gagaacgagc agacatccgc cccctctaag     1140

accacactgc cacccaccga gaaccctacc acagccaaga gcaccaattc cacaaagtct     1200

ccaaccacaa ccgtgcccaa cacaaccaat aagcactcca cctctcctag cccaaccccc     1260

aaccctacag cccagcacct ggtgtatttc aggagaaagc ggaatatcct gtggcgcgag     1320

ggcgacatgt tcccctttct ggatggcctg atcaacgccc ctatcgactt cgatccagtg     1380

cccaatacca agacaatctt tgacgagtcc tctagctccg gagcaagcgc cgaggaggat     1440

cagcacgcct ctcctaacat cagcctgaca ctgtcctact ttccaaagat caacgagaat     1500

accgcctatt ccggcgagaa cgagaatgac tgcgatgccg agctgaggat ctggagcgtg     1560

caggaggacg atctggcagc aggactgtcc tggattccct tcttcggacc tggaatcgag     1620

ggactgtaca ccgcaggact gatcaagaac cagaacaacc tggtgtgcag actgcggcgc     1680

ctggccaatc agacagccaa gtccctggag ctgctgctgc gggtgacaac cgaggagcgc     1740

accttctctc tgatcaaccg gcacgccatc gactttctgc tggcaagatg gggcggcacc     1800

tgcaaggtgc tgggaccaga ctgctgtatc ggcatcgagg atctgtctcg gaatatcagc     1860

gagcagatcg accagatcaa gaaggatgag cagaaggagg gaaccggatg gggactgggc     1920

ggcaagtggt ggacaagcga ttggggcgtg ctgaccaacc tgggcatcct gctgctgctg     1980

tctatcgccg tgctgatcgc cctgagctgc atctgtcgca tcttcaccaa gtatatcggc     2040


<210>  2
<211>  680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of Con 1

<400>  2

Met Lys Thr Thr Cys Leu Phe Ile Ser Leu Ile Leu Ile Gln Gly Val 
1               5                   10                  15      


Lys Thr Leu Pro Ile Leu Glu Ile Ala Ser Asn Asn Gln Pro Gln Asn 
            20                  25                  30          


Val Asp Ser Val Cys Ser Gly Thr Leu Gln Lys Thr Glu Asp Val His 
        35                  40                  45              


Leu Met Gly Phe Thr Leu Ser Gly Gln Lys Val Ala Asp Ser Pro Leu 
    50                  55                  60                  


Glu Ala Ser Lys Arg Trp Ala Phe Arg Thr Gly Val Pro Pro Lys Asn 
65                  70                  75                  80  


Val Glu Tyr Thr Glu Gly Glu Glu Ala Lys Thr Cys Tyr Asn Ile Ser 
                85                  90                  95      


Val Thr Asp Pro Ser Gly Lys Ser Leu Leu Leu Asp Pro Pro Thr Asn 
            100                 105                 110         


Ile Arg Asp Tyr Pro Lys Cys Lys Thr Ile His His Ile Gln Gly Gln 
        115                 120                 125             


Asn Pro His Ala Gln Gly Ile Ala Leu His Leu Trp Gly Ala Phe Phe 
    130                 135                 140                 


Leu Tyr Asp Arg Ile Ala Ser Thr Thr Met Tyr Arg Gly Lys Val Phe 
145                 150                 155                 160 


Thr Glu Gly Asn Ile Ala Ala Met Ile Val Asn Lys Thr Val His Lys 
                165                 170                 175     


Met Ile Phe Ser Arg Gln Gly Gln Gly Tyr Arg His Met Asn Leu Thr 
            180                 185                 190         


Ser Thr Asn Lys Tyr Trp Thr Ser Ser Asn Gly Thr Gln Thr Asn Asp 
        195                 200                 205             


Thr Gly Cys Phe Gly Ala Leu Gln Glu Tyr Asn Ser Thr Lys Asn Gln 
    210                 215                 220                 


Thr Cys Ala Pro Ser Lys Ile Pro Leu Pro Leu Pro Thr Ala Arg Pro 
225                 230                 235                 240 


Glu Val Lys Leu Thr Ser Thr Ser Thr Asp Ala Thr Lys Leu Asn Thr 
                245                 250                 255     


Thr Asp Pro Asn Ser Asp Asp Glu Asp Leu Thr Thr Ser Gly Ser Gly 
            260                 265                 270         


Ser Gly Glu Gln Glu Pro Tyr Thr Thr Ser Asp Ala Ala Thr Lys Gln 
        275                 280                 285             


Gly Leu Ser Ser Thr Met Pro Pro Thr Pro Ser Pro Gln Pro Ser Thr 
    290                 295                 300                 


Pro Gln Gln Glu Gly Asn Asn Thr Asn His Ser Gln Gly Ala Val Thr 
305                 310                 315                 320 


Glu Pro Gly Lys Thr Asn Thr Thr Ala Gln Pro Ser Met Pro Pro His 
                325                 330                 335     


Asn Thr Thr Ala Ile Ser Thr Asn Asn Thr Ser Lys His Asn Phe Ser 
            340                 345                 350         


Thr Pro Ser Val Pro Leu Gln Asn Ala Thr Asn Tyr Asn Thr Gln Ser 
        355                 360                 365             


Thr Ala Thr Glu Asn Glu Gln Thr Ser Ala Pro Ser Lys Thr Thr Leu 
    370                 375                 380                 


Pro Pro Thr Glu Asn Pro Thr Thr Ala Lys Ser Thr Asn Ser Thr Lys 
385                 390                 395                 400 


Ser Pro Thr Thr Thr Val Pro Asn Thr Thr Asn Lys His Ser Thr Ser 
                405                 410                 415     


Pro Ser Pro Thr Pro Asn Pro Thr Ala Gln His Leu Val Tyr Phe Arg 
            420                 425                 430         


Arg Lys Arg Asn Ile Leu Trp Arg Glu Gly Asp Met Phe Pro Phe Leu 
        435                 440                 445             


Asp Gly Leu Ile Asn Ala Pro Ile Asp Phe Asp Pro Val Pro Asn Thr 
    450                 455                 460                 


Lys Thr Ile Phe Asp Glu Ser Ser Ser Ser Gly Ala Ser Ala Glu Glu 
465                 470                 475                 480 


Asp Gln His Ala Ser Pro Asn Ile Ser Leu Thr Leu Ser Tyr Phe Pro 
                485                 490                 495     


Lys Ile Asn Glu Asn Thr Ala Tyr Ser Gly Glu Asn Glu Asn Asp Cys 
            500                 505                 510         


Asp Ala Glu Leu Arg Ile Trp Ser Val Gln Glu Asp Asp Leu Ala Ala 
        515                 520                 525             


Gly Leu Ser Trp Ile Pro Phe Phe Gly Pro Gly Ile Glu Gly Leu Tyr 
    530                 535                 540                 


Thr Ala Gly Leu Ile Lys Asn Gln Asn Asn Leu Val Cys Arg Leu Arg 
545                 550                 555                 560 


Arg Leu Ala Asn Gln Thr Ala Lys Ser Leu Glu Leu Leu Leu Arg Val 
                565                 570                 575     


Thr Thr Glu Glu Arg Thr Phe Ser Leu Ile Asn Arg His Ala Ile Asp 
            580                 585                 590         


Phe Leu Leu Ala Arg Trp Gly Gly Thr Cys Lys Val Leu Gly Pro Asp 
        595                 600                 605             


Cys Cys Ile Gly Ile Glu Asp Leu Ser Arg Asn Ile Ser Glu Gln Ile 
    610                 615                 620                 


Asp Gln Ile Lys Lys Asp Glu Gln Lys Glu Gly Thr Gly Trp Gly Leu 
625                 630                 635                 640 


Gly Gly Lys Trp Trp Thr Ser Asp Trp Gly Val Leu Thr Asn Leu Gly 
                645                 650                 655     


Ile Leu Leu Leu Leu Ser Ile Ala Val Leu Ile Ala Leu Ser Cys Ile 
            660                 665                 670         


Cys Arg Ile Phe Thr Lys Tyr Ile Gly Lys Thr Thr Cys Leu Phe Ile 
        675                 680     1               5           


Ser Leu Ile Leu Ile Gln Gly Val Lys Thr Leu Pro Ile Leu Glu Ile 
        10                  15                  20              


Ala Ser Asn Asn Gln Pro Gln Asn Val Asp Ser Val Cys Ser Gly Thr 
    25                  30                  35                  


Leu Gln Lys Thr Glu Asp Val His Leu Met Gly Phe Thr Leu Ser Gly 
40                  45                  50                  55  


Gln Lys Val Ala Asp Ser Pro Leu Glu Ala Ser Lys Arg Trp Ala Phe 
                60                  65                  70      


Arg Thr Gly Val Pro Pro Lys Asn Val Glu Tyr Thr Glu Gly Glu Glu 
            75                  80                  85          


Ala Lys Thr Cys Tyr Asn Ile Ser Val Thr Asp Pro Ser Gly Lys Ser 
        90                  95                  100             


Leu Leu Leu Asp Pro Pro Thr Asn Ile Arg Asp Tyr Pro Lys Cys Lys 
    105                 110                 115                 


Thr Ile His His Ile Gln Gly Gln Asn Pro His Ala Gln Gly Ile Ala 
120                 125                 130                 135 


Leu His Leu Trp Gly Ala Phe Phe Leu Tyr Asp Arg Ile Ala Ser Thr 
                140                 145                 150     


Thr Met Tyr Arg Gly Lys Val Phe Thr Glu Gly Asn Ile Ala Ala Met 
            155                 160                 165         


Ile Val Asn Lys Thr Val His Lys Met Ile Phe Ser Arg Gln Gly Gln 
        170                 175                 180             


Gly Tyr Arg His Met Asn Leu Thr Ser Thr Asn Lys Tyr Trp Thr Ser 
    185                 190                 195                 


Ser Asn Gly Thr Gln Thr Asn Asp Thr Gly Cys Phe Gly Ala Leu Gln 
200                 205                 210                 215 


Glu Tyr Asn Ser Thr Lys Asn Gln Thr Cys Ala Pro Ser Lys Ile Pro 
                220                 225                 230     


Leu Pro Leu Pro Thr Ala Arg Pro Glu Val Lys Leu Thr Ser Thr Ser 
            235                 240                 245         


Thr Asp Ala Thr Lys Leu Asn Thr Thr Asp Pro Asn Ser Asp Asp Glu 
        250                 255                 260             


Asp Leu Thr Thr Ser Gly Ser Gly Ser Gly Glu Gln Glu Pro Tyr Thr 
    265                 270                 275                 


Thr Ser Asp Ala Ala Thr Lys Gln Gly Leu Ser Ser Thr Met Pro Pro 
280                 285                 290                 295 


Thr Pro Ser Pro Gln Pro Ser Thr Pro Gln Gln Glu Gly Asn Asn Thr 
                300                 305                 310     


Asn His Ser Gln Gly Ala Val Thr Glu Pro Gly Lys Thr Asn Thr Thr 
            315                 320                 325         


Ala Gln Pro Ser Met Pro Pro His Asn Thr Thr Ala Ile Ser Thr Asn 
        330                 335                 340             


Asn Thr Ser Lys His Asn Phe Ser Thr Pro Ser Val Pro Leu Gln Asn 
    345                 350                 355                 


Ala Thr Asn Tyr Asn Thr Gln Ser Thr Ala Thr Glu Asn Glu Gln Thr 
360                 365                 370                 375 


Ser Ala Pro Ser Lys Thr Thr Leu Pro Pro Thr Glu Asn Pro Thr Thr 
                380                 385                 390     


Ala Lys Ser Thr Asn Ser Thr Lys Ser Pro Thr Thr Thr Val Pro Asn 
            395                 400                 405         


Thr Thr Asn Lys His Ser Thr Ser Pro Ser Pro Thr Pro Asn Pro Thr 
        410                 415                 420             


Ala Gln His Leu Val Tyr Phe Arg Arg Lys Arg Asn Ile Leu Trp Arg 
    425                 430                 435                 


Glu Gly Asp Met Phe Pro Phe Leu Asp Gly Leu Ile Asn Ala Pro Ile 
440                 445                 450                 455 


Asp Phe Asp Pro Val Pro Asn Thr Lys Thr Ile Phe Asp Glu Ser Ser 
                460                 465                 470     


Ser Ser Gly Ala Ser Ala Glu Glu Asp Gln His Ala Ser Pro Asn Ile 
            475                 480                 485         


Ser Leu Thr Leu Ser Tyr Phe Pro Lys Ile Asn Glu Asn Thr Ala Tyr 
        490                 495                 500             


Ser Gly Glu Asn Glu Asn Asp Cys Asp Ala Glu Leu Arg Ile Trp Ser 
    505                 510                 515                 


Val Gln Glu Asp Asp Leu Ala Ala Gly Leu Ser Trp Ile Pro Phe Phe 
520                 525                 530                 535 


Gly Pro Gly Ile Glu Gly Leu Tyr Thr Ala Gly Leu Ile Lys Asn Gln 
                540                 545                 550     


Asn Asn Leu Val Cys Arg Leu Arg Arg Leu Ala Asn Gln Thr Ala Lys 
            555                 560                 565         


Ser Leu Glu Leu Leu Leu Arg Val Thr Thr Glu Glu Arg Thr Phe Ser 
        570                 575                 580             


Leu Ile Asn Arg His Ala Ile Asp Phe Leu Leu Ala Arg Trp Gly Gly 
    585                 590                 595                 


Thr Cys Lys Val Leu Gly Pro Asp Cys Cys Ile Gly Ile Glu Asp Leu 
600                 605                 610                 615 


Ser Arg Asn Ile Ser Glu Gln Ile Asp Gln Ile Lys Lys Asp Glu Gln 
                620                 625                 630     


Lys Glu Gly Thr Gly Trp Gly Leu Gly Gly Lys Trp Trp Thr Ser Asp 
            635                 640                 645         


Trp Gly Val Leu Thr Asn Leu Gly Ile Leu Leu Leu Leu Ser Ile Ala 
        650                 655                 660             


Val Leu Ile Ala Leu Ser Cys Ile Cys Arg Ile Phe Thr Lys Tyr Ile 
    665                 670                 675                 


Gly 
680 


<210>  3
<211>  2040
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of Con 2

<400>  3
aagaccacat gcctgttcat cagcctgatc ctgatccagg gcgtgaagac cctgccaatc       60

ctggagatcg cctccaacaa tcagccccag aacgtggaca gcgtgtgctc tggcaccctg      120

cagaagacag aggatgtgca cctgatgggc ttcacactga gcggacagaa ggtggcagac      180

tccccactgg aggcctctaa gaggtgggcc tttagaaccg gcgtgccccc taagaacgtg      240

gagtacaccg agggcgagga ggccaagaca tgctataata tctccgtgac cgatcccagc      300

ggcaagtccc tgctgctgga cccacccaca aacatcaggg attaccctaa gtgtaagacc      360

atccaccaca tccagggcca gaatccacac gcacagggaa tcgccctgca cctgtggggc      420

gccttctttc tgtacgacag gatcgccagc accacaatgt atagaggcaa ggtgttcaca      480

gagggcaaca tcgccgccat gatcgtgaat aagaccgtgc acaagatgat cttttctagg      540

cagggccagg gctacagaca catgaacctg acaagcacca ataagtattg gacaagctcc      600

aacggcacac agaccaatga caccggatgc ttcggcgccc tgcaggagta caactccacc      660

aagaatcaga catgtgcccc atctaagatc cctctgccac tgccaacagc aaggccagag      720

gtgaagctga catctaccag cacagacgcc accaagctga acaccacaga ccccaattcc      780

gacgatgagg atctgaccac atccggctct ggcagcggag agcaggagcc ttataccaca      840

tctgatgccg ccaccaagca gggcctgtct agcaccatgc ctccaacacc tagcccacag      900

ccctccacac ctcagcagga gggcaacaat accaaccact ctcagggagc agtgaccgag      960

cctggcaaga caaacaccac agcccagcca agcatgcccc ctcacaatac cacagccatc     1020

agcaccaaca atacatccaa gcacaacttt tctaccccta gcgtgccact gcagaatgcc     1080

accaactaca atacacagtc caccgccaca gagaacgagc agacatccgc cccctctaag     1140

accacactgc cacccaccga gaaccctacc acagccaaga gcaccaattc cacaaagtct     1200

ccaaccacaa ccgtgcccaa cacaaccaat aagcactcca cctctcctag cccaaccccc     1260

aaccctacag cccagcacct ggtgtatttc aggagaaagc ggaatatcct gtggcgcgag     1320

ggcgacatgt tcccctttct ggatggcctg atcaacgccc ctatcgactt cgatccagtg     1380

cccaatacca agacaatctt tgacgagtcc tctagctccg gagcaagcgc cgaggaggat     1440

cagcacgcct ctcctaacat cagcctgaca ctgtcctact ttccaaagat caacgagaat     1500

accgcctatt ccggcgagaa cgagaatgac tgcgatgccg agctgaggat ctggagcgtg     1560

caggaggacg atctggcagc aggactgtcc tggattccct tcttcggacc tggaatcgag     1620

ggactgtaca ccgcaggact gatcaagaac cagaacaacc tggtgtgcag actgcggcgc     1680

ctggccaatc agacagccaa gtccctggag ctgctgctgc gggtgacaac cgaggagcgc     1740

accttctctc tgatcaaccg gcacgccatc gactttctgc tggcaagatg gggcggcacc     1800

tgcaaggtgc tgggaccaga ctgctgtatc ggcatcgagg atctgtctcg gaatatcagc     1860

gagcagatcg accagatcaa gaaggatgag cagaaggagg gaaccggatg gggactgggc     1920

ggcaagtggt ggacaagcga ttggggcgtg ctgaccaacc tgggcatcct gctgctgctg     1980

tctatcgccg tgctgatcgc cctgagctgc atctgtcgca tcttcaccaa gtatatcggc     2040


<210>  4
<211>  680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of Con 2

<400>  4

Arg Thr Thr Cys Phe Phe Ile Ser Leu Ile Leu Ile Gln Gly Ile Lys 
1               5                   10                  15      


Thr Leu Pro Ile Leu Glu Ile Ala Ser Asn Asp Gln Pro Gln Asn Val 
            20                  25                  30          


Asp Ser Val Cys Ser Gly Thr Leu Gln Lys Thr Glu Asp Val His Leu 
        35                  40                  45              


Met Gly Phe Thr Leu Ser Gly Gln Lys Val Ala Asp Ser Pro Leu Glu 
    50                  55                  60                  


Ala Ser Lys Arg Trp Ala Phe Arg Thr Gly Val Pro Pro Lys Asn Val 
65                  70                  75                  80  


Glu Tyr Thr Glu Gly Glu Glu Ala Lys Thr Cys Tyr Asn Ile Ser Val 
                85                  90                  95      


Thr Asp Pro Ser Gly Lys Ser Leu Leu Leu Asp Pro Pro Thr Asn Val 
            100                 105                 110         


Arg Asp Tyr Pro Lys Cys Lys Thr Ile His His Ile Gln Gly Gln Asn 
        115                 120                 125             


Pro His Ala Gln Gly Ile Ala Leu His Leu Trp Gly Ala Phe Phe Leu 
    130                 135                 140                 


Tyr Asp Arg Ile Ala Ser Thr Thr Met Tyr Arg Gly Lys Val Phe Thr 
145                 150                 155                 160 


Glu Gly Asn Ile Ala Ala Met Ile Val Asn Lys Thr Val His Lys Met 
                165                 170                 175     


Ile Phe Ser Arg Gln Gly Gln Gly Tyr Arg His Met Asn Leu Thr Ser 
            180                 185                 190         


Thr Asn Lys Tyr Trp Thr Ser Ser Asn Gly Thr Gln Thr Asn Asp Thr 
        195                 200                 205             


Gly Cys Phe Gly Thr Leu Gln Glu Tyr Asn Ser Thr Lys Asn Gln Thr 
    210                 215                 220                 


Cys Ala Pro Ser Lys Thr Pro Pro Pro Pro Pro Thr Ala Arg Pro Glu 
225                 230                 235                 240 


Ile Lys Pro Thr Ser Thr Pro Thr Asp Ala Thr Arg Leu Asn Thr Thr 
                245                 250                 255     


Asn Pro Asn Ser Asp Asp Glu Asp Leu Thr Thr Ser Gly Ser Gly Ser 
            260                 265                 270         


Gly Glu Gln Glu Pro Tyr Thr Thr Ser Asp Ala Val Thr Lys Gln Gly 
        275                 280                 285             


Leu Ser Ser Thr Met Pro Pro Thr Pro Ser Pro Gln Pro Gly Thr Pro 
    290                 295                 300                 


Gln Gln Gly Gly Asn Asn Thr Asn His Ser Gln Asp Ala Thr Thr Glu 
305                 310                 315                 320 


Leu Asp Asn Thr Asn Thr Thr Ala Gln Pro Pro Met Pro Ser His Asn 
                325                 330                 335     


Thr Thr Thr Ile Ser Thr Asn Asn Thr Ser Lys His Asn Leu Ser Thr 
            340                 345                 350         


Leu Ser Glu Pro Pro Gln Asn Thr Thr Asn Pro Asn Thr Gln Ser Met 
        355                 360                 365             


Val Thr Glu Asn Glu Lys Thr Ser Ala Pro Pro Lys Ala Thr Leu Pro 
    370                 375                 380                 


Pro Thr Glu Asn Pro Thr Thr Glu Lys Ser Thr Asn Asn Thr Lys Ser 
385                 390                 395                 400 


Pro Thr Thr Leu Glu Pro Asn Lys Thr Asn Gly His Phe Thr Ser Pro 
                405                 410                 415     


Ser Ser Thr Pro Asn Ser Thr Thr Gln His Leu Ile Tyr Phe Arg Arg 
            420                 425                 430         


Lys Arg Ser Ile Leu Trp Arg Glu Gly Asp Met Phe Pro Phe Leu Asp 
        435                 440                 445             


Gly Leu Ile Asn Ala Pro Ile Asp Phe Asp Pro Val Pro Asn Thr Lys 
    450                 455                 460                 


Thr Ile Phe Asp Glu Ser Ser Ser Ser Gly Ala Ser Ala Glu Glu Asp 
465                 470                 475                 480 


Gln His Ala Ser Ser Asn Ile Ser Leu Thr Leu Ser Tyr Leu Pro His 
                485                 490                 495     


Thr Ser Glu Asn Thr Ala Tyr Ser Gly Glu Asn Glu Asn Asp Cys Asp 
            500                 505                 510         


Ala Glu Leu Arg Ile Trp Ser Val Gln Glu Asp Asp Leu Ala Ala Gly 
        515                 520                 525             


Leu Ser Trp Ile Pro Leu Phe Gly Pro Gly Ile Glu Gly Leu Tyr Thr 
    530                 535                 540                 


Ala Gly Leu Ile Lys Asn Gln Asn Asn Leu Val Cys Arg Leu Arg Arg 
545                 550                 555                 560 


Leu Ala Asn Gln Thr Ala Lys Ser Leu Glu Leu Leu Leu Arg Val Thr 
                565                 570                 575     


Thr Glu Glu Arg Thr Phe Ser Leu Ile Asn Arg His Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Thr Arg Trp Gly Gly Thr Cys Lys Val Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Gly Ile Glu Asp Leu Ser Arg Asn Ile Ser Glu Gln Ile Asp 
    610                 615                 620                 


Gln Ile Lys Lys Asp Glu Gln Lys Glu Gly Thr Gly Trp Gly Leu Gly 
625                 630                 635                 640 


Gly Lys Trp Trp Thr Ser Asp Trp Gly Val Leu Thr Asn Leu Gly Ile 
                645                 650                 655     


Leu Leu Leu Leu Ser Ile Ala Val Leu Ile Ala Leu Ser Cys Ile Cys 
            660                 665                 670         


Arg Ile Phe Thr Lys Tyr Ile Gly 
        675                 680 


<210>  5
<211>  2040
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of Con 3

<400>  5
aagacaatct acttcctgat ctctctgatc ctgatccaga gcatcaagac cctgccagtg       60

ctggagatcg cctccaactc tcagccccag gacgtggata gcgtgtgctc tggcaccctg      120

cagaagacag aggacgtgca cctgatgggc ttcacactgt ccggccagaa ggtggccgat      180

tcccctctgg aggcctctaa gaggtgggcc tttagaaccg gcgtgccccc taagaacgtg      240

gagtacaccg agggcgagga ggccaagaca tgctataata tctccgtgac cgacccaagc      300

ggcaagtccc tgctgctgga cccaccctct aacatcaggg attaccccaa gtgtaagacc      360

gtgcaccaca tccagggcca gaatcctcac gcacagggaa tcgccctgca cctgtggggc      420

gccttctttc tgtacgatcg ggtggccagc accacaatgt atcgcggcaa ggtgttcaca      480

gagggcaaca tcgccgccat gatcgtgaat aagaccgtgc accggatgat cttttctcgc      540

cagggccagg gctacaggca catgaacctg accagcacaa ataagtattg gacaagctcc      600

aacgagaccc agagaaatga cacaggctgc tttggcatcc tgcaggagta taactccacc      660

aacaatcaga catgtcctcc aagcctgaag cccccttccc tgcctaccgt gacaccatct      720

atccacagca ccaacacaca gatcaatacc gccaagagcg gcacaatgaa cccttctagc      780

gacgatgagg acctgatgat cagcggctcc ggctctggag agcagggacc acacaccaca      840

ctgaatgtgg tgaccgagca gaagcagtcc tctaccatcc tgtccacacc atctctgcac      900

ctgagcacat cccagcacga gcagaactct accaatccca gccggcacgc agtgaccgag      960

cacaacggca cagaccccac cacacagcct gccaccctgc tgaacaatac aaataccaca     1020

cctacctaca acacactgaa gtataatctg agcacaccat ccccacccac caggaacatc     1080

acaaacaatg atacccagag agagctggcc gagtccgagc agaccaacgc ccagctgaat     1140

accacactgg acccaacaga gaaccccacc acaggccagg ataccaactc taccacaaat     1200

atcatcatga ccacatccga catcacctct aagcacccaa caaatagctc ccctgattct     1260

agcccaacca cacgccctcc aatctacttc aggaagaaga ggagcatctt ttggaaggag     1320

ggcgacatct tcccctttct ggatggcctg atcagcaccg agatcgactt cgatccaatc     1380

cccaacaccg agacaatctt cgacgagtct cccagcttta acacctccac aaatgaggag     1440

cagcacacac cccctaacat cagcctgacc ttctcctact ttcctgacaa gaatggcgat     1500

accgcctata gcggcgagaa cgagaatgac tgcgatgccg agctgcggat ctggagcgtg     1560

caggaggacg atctggcagc aggactgtcc tggattccct tcttcggccc tggcatcgag     1620

ggcctgtata ccgccggcct gatcaagaac cagaacaacc tggtgtgccg cctgaggaga     1680

ctggccaatc agacagccaa gagcctggag ctgctgctga gggtgaccac agaggagaga     1740

accttctccc tgatcaaccg gcacgccatc gactttctgc tgacccgctg gggcggcaca     1800

tgcaaggtgc tgggaccaga ctgctgtatc ggcatcgagg atctgtctaa gaatatcagc     1860

gagcagatcg acaagatcag gaaggatgag cagaaggagg agaccggatg gggactgggc     1920

ggcaagtggt ggacaagcga ttggggcgtg ctgaccaacc tgggcatcct gctgctgctg     1980

tccatcgccg tgctgatcgc cctgtcttgc atctgtagaa tcttcaccaa gtacatcggc     2040


<210>  6
<211>  680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of Con 3

<400>  6

Lys Thr Ile Tyr Phe Leu Ile Ser Leu Ile Leu Ile Gln Ser Ile Lys 
1               5                   10                  15      


Thr Leu Pro Val Leu Glu Ile Ala Ser Asn Ser Gln Pro Gln Asp Val 
            20                  25                  30          


Asp Ser Val Cys Ser Gly Thr Leu Gln Lys Thr Glu Asp Val His Leu 
        35                  40                  45              


Met Gly Phe Thr Leu Ser Gly Gln Lys Val Ala Asp Ser Pro Leu Glu 
    50                  55                  60                  


Ala Ser Lys Arg Trp Ala Phe Arg Thr Gly Val Pro Pro Lys Asn Val 
65                  70                  75                  80  


Glu Tyr Thr Glu Gly Glu Glu Ala Lys Thr Cys Tyr Asn Ile Ser Val 
                85                  90                  95      


Thr Asp Pro Ser Gly Lys Ser Leu Leu Leu Asp Pro Pro Ser Asn Ile 
            100                 105                 110         


Arg Asp Tyr Pro Lys Cys Lys Thr Val His His Ile Gln Gly Gln Asn 
        115                 120                 125             


Pro His Ala Gln Gly Ile Ala Leu His Leu Trp Gly Ala Phe Phe Leu 
    130                 135                 140                 


Tyr Asp Arg Val Ala Ser Thr Thr Met Tyr Arg Gly Lys Val Phe Thr 
145                 150                 155                 160 


Glu Gly Asn Ile Ala Ala Met Ile Val Asn Lys Thr Val His Arg Met 
                165                 170                 175     


Ile Phe Ser Arg Gln Gly Gln Gly Tyr Arg His Met Asn Leu Thr Ser 
            180                 185                 190         


Thr Asn Lys Tyr Trp Thr Ser Ser Asn Glu Thr Gln Arg Asn Asp Thr 
        195                 200                 205             


Gly Cys Phe Gly Ile Leu Gln Glu Tyr Asn Ser Thr Asn Asn Gln Thr 
    210                 215                 220                 


Cys Pro Pro Ser Leu Lys Pro Pro Ser Leu Pro Thr Val Thr Pro Ser 
225                 230                 235                 240 


Ile His Ser Thr Asn Thr Gln Ile Asn Thr Ala Lys Ser Gly Thr Met 
                245                 250                 255     


Asn Pro Ser Ser Asp Asp Glu Asp Leu Met Ile Ser Gly Ser Gly Ser 
            260                 265                 270         


Gly Glu Gln Gly Pro His Thr Thr Leu Asn Val Val Thr Glu Gln Lys 
        275                 280                 285             


Gln Ser Ser Thr Ile Leu Ser Thr Pro Ser Leu His Leu Ser Thr Ser 
    290                 295                 300                 


Gln His Glu Gln Asn Ser Thr Asn Pro Ser Arg His Ala Val Thr Glu 
305                 310                 315                 320 


His Asn Gly Thr Asp Pro Thr Thr Gln Pro Ala Thr Leu Leu Asn Asn 
                325                 330                 335     


Thr Asn Thr Thr Pro Thr Tyr Asn Thr Leu Lys Tyr Asn Leu Ser Thr 
            340                 345                 350         


Pro Ser Pro Pro Thr Arg Asn Ile Thr Asn Asn Asp Thr Gln Arg Glu 
        355                 360                 365             


Leu Ala Glu Ser Glu Gln Thr Asn Ala Gln Leu Asn Thr Thr Leu Asp 
    370                 375                 380                 


Pro Thr Glu Asn Pro Thr Thr Gly Gln Asp Thr Asn Ser Thr Thr Asn 
385                 390                 395                 400 


Ile Ile Met Thr Thr Ser Asp Ile Thr Ser Lys His Pro Thr Asn Ser 
                405                 410                 415     


Ser Pro Asp Ser Ser Pro Thr Thr Arg Pro Pro Ile Tyr Phe Arg Lys 
            420                 425                 430         


Lys Arg Ser Ile Phe Trp Lys Glu Gly Asp Ile Phe Pro Phe Leu Asp 
        435                 440                 445             


Gly Leu Ile Ser Thr Glu Ile Asp Phe Asp Pro Ile Pro Asn Thr Glu 
    450                 455                 460                 


Thr Ile Phe Asp Glu Ser Pro Ser Phe Asn Thr Ser Thr Asn Glu Glu 
465                 470                 475                 480 


Gln His Thr Pro Pro Asn Ile Ser Leu Thr Phe Ser Tyr Phe Pro Asp 
                485                 490                 495     


Lys Asn Gly Asp Thr Ala Tyr Ser Gly Glu Asn Glu Asn Asp Cys Asp 
            500                 505                 510         


Ala Glu Leu Arg Ile Trp Ser Val Gln Glu Asp Asp Leu Ala Ala Gly 
        515                 520                 525             


Leu Ser Trp Ile Pro Phe Phe Gly Pro Gly Ile Glu Gly Leu Tyr Thr 
    530                 535                 540                 


Ala Gly Leu Ile Lys Asn Gln Asn Asn Leu Val Cys Arg Leu Arg Arg 
545                 550                 555                 560 


Leu Ala Asn Gln Thr Ala Lys Ser Leu Glu Leu Leu Leu Arg Val Thr 
                565                 570                 575     


Thr Glu Glu Arg Thr Phe Ser Leu Ile Asn Arg His Ala Ile Asp Phe 
            580                 585                 590         


Leu Leu Thr Arg Trp Gly Gly Thr Cys Lys Val Leu Gly Pro Asp Cys 
        595                 600                 605             


Cys Ile Gly Ile Glu Asp Leu Ser Lys Asn Ile Ser Glu Gln Ile Asp 
    610                 615                 620                 


Lys Ile Arg Lys Asp Glu Gln Lys Glu Glu Thr Gly Trp Gly Leu Gly 
625                 630                 635                 640 


Gly Lys Trp Trp Thr Ser Asp Trp Gly Val Leu Thr Asn Leu Gly Ile 
                645                 650                 655     


Leu Leu Leu Leu Ser Ile Ala Val Leu Ile Ala Leu Ser Cys Ile Cys 
            660                 665                 670         


Arg Ile Phe Thr Lys Tyr Ile Gly 
        675                 680 


<210>  7
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding an IgE signal peptide

<400>  7
atggactgga cctggatcct gttcctggtg gccgctgcca cacgggtgca cagc             54


<210>  8
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence for the IgE signal peptide

<400>  8

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


