                         SEQUENCE LISTING

<110>  The Jackson Laboratory
 
<120>  HUMANIZED MOUSE MODEL WITH IMPROVED HUMAN INNATE IMMUNE CELL 
       DEVELOPMENT

<130>  47JLA12152WO

<150>  62/428,131
<151>  2016-11-30

<150>  62/565,783
<151>  2017-09-29

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  1662
<212>  DNA
<213>  Homo sapiens

<400>  1
atgaccgcgc cgggcgccgc cgggcgctgc cctcccacga catggctggg ctccctgctg       60

ttgttggtct gtctcctggc gagcaggagt atcaccgagg aggtgtcgga gtactgtagc      120

cacatgattg ggagtggaca cctgcagtct ctgcagcggc tgattgacag tcagatggag      180

acctcgtgcc aaattacatt tgagtttgta gaccaggaac agttgaaaga tccagtgtgc      240

taccttaaga aggcatttct cctggtacaa gacataatgg aggacaccat gcgcttcaga      300

gataacaccc ccaatgccat cgccattgtg cagctgcagg aactctcttt gaggctgaag      360

agctgcttca ccaaggatta tgaagagcat gacaaggcct gcgtccgaac tttctatgag      420

acacctctcc agttgctgga gaaggtcaag aatgtcttta atgaaacaaa gaatctcctt      480

gacaaggact ggaatatttt cagcaagaac tgcaacaaca gctttgctga atgctccagc      540

caagatgtgg tgaccaagcc tgattgcaac tgcctgtacc ccaaagccat ccctagcagt      600

gacccggcct ctgtctcccc tcatcagccc ctcgccccct ccatggcccc tgtggctggc      660

ttgacctggg aggactctga gggaactgag ggcagctccc tcttgcctgg tgagcagccc      720

ctgcacacag tggatccagg cagtgccaag cagcggccac ccaggagcac ctgccagagc      780

tttgagccgc cagagacccc agttgtcaag gacagcacca tcggtggctc accacagcct      840

cgcccctctg tcggggcctt caaccccggg atggaggata ttcttgactc tgcaatgggc      900

actaattggg tcccagaaga agcctctgga gaggccagtg agattcccgt accccaaggg      960

acagagcttt ccccctccag gccaggaggg ggcagcatgc agacagagcc cgccagaccc     1020

agcaacttcc tctcagcatc ttctccactc cctgcatcag caaagggcca acagccggca     1080

gatgtaactg gtaccgcctt gcccagggtg ggccccgtga ggcccactgg ccaggactgg     1140

aatcacaccc cccagaagac agaccatcca tctgccctgc tcagagaccc cccggagcca     1200

ggctctccca ggatctcatc actgcgcccc cagggcctca gcaacccctc caccctctct     1260

gctcagccac agctttccag aagccactcc tcgggcagcg tgctgcccct tggggagctg     1320

gagggcagga ggagcaccag ggatcggagg agccccgcag agccagaagg aggaccagca     1380

agtgaagggg cagccaggcc cctgccccgt tttaactccg ttcctttgac tgacacaggc     1440

catgagaggc agtccgaggg atcctccagc ccgcagctcc aggagtctgt cttccacctg     1500

ctggtgccca gtgtcatcct ggtcttgctg gccgtcggag gcctcttgtt ctacaggtgg     1560

aggcggcgga gccatcaaga gcctcagaga gcggattctc ccttggagca accagagggc     1620

agccccctga ctcaggatga cagacaggtg gaactgccag tg                        1662


<210>  2
<211>  1314
<212>  DNA
<213>  Homo sapiens

<400>  2
atgaccgcgc cgggcgccgc cgggcgctgc cctcccacga catggctggg ctccctgctg       60

ttgttggtct gtctcctggc gagcaggagt atcaccgagg aggtgtcgga gtactgtagc      120

cacatgattg ggagtggaca cctgcagtct ctgcagcggc tgattgacag tcagatggag      180

acctcgtgcc aaattacatt tgagtttgta gaccaggaac agttgaaaga tccagtgtgc      240

taccttaaga aggcatttct cctggtacaa gacataatgg aggacaccat gcgcttcaga      300

gataacaccc ccaatgccat cgccattgtg cagctgcagg aactctcttt gaggctgaag      360

agctgcttca ccaaggatta tgaagagcat gacaaggcct gcgtccgaac tttctatgag      420

acacctctcc agttgctgga gaaggtcaag aatgtcttta atgaaacaaa gaatctcctt      480

gacaaggact ggaatatttt cagcaagaac tgcaacaaca gctttgctga atgctccagc      540

caagatgtgg tgaccaagcc tgattgcaac tgcctgtacc ccaaagccat ccctagcagt      600

gacccggcct ctgtctcccc tcatcagccc ctcgccccct ccatggcccc tgtggctggc      660

ttgacctggg aggactctga gggaactgag ggcagctccc tcttgcctgg tgagcagccc      720

ctgcacacag tggatccagg cagtgccaag cagcggccac ccaggagcac ctgccagagc      780

tttgagccgc cagagacccc agttgtcaag gacagcacca tcggtggctc accacagcct      840

cgcccctctg tcggggcctt caaccccggg atggaggata ttcttgactc tgcaatgggc      900

actaattggg tcccagaaga agcctctgga gaggccagtg agattcccgt accccaaggg      960

acagagcttt ccccctccag gccaggaggg ggcagcatgc agacagagcc cgccagaccc     1020

agcaacttcc tctcagcatc ttctccactc cctgcatcag caaagggcca acagccggca     1080

gatgtaactg gccatgagag gcagtccgag ggatcctcca gcccgcagct ccaggagtct     1140

gtcttccacc tgctggtgcc cagtgtcatc ctggtcttgc tggccgtcgg aggcctcttg     1200

ttctacaggt ggaggcggcg gagccatcaa gagcctcaga gagcggattc tcccttggag     1260

caaccagagg gcagccccct gactcaggat gacagacagg tggaactgcc agtg           1314


<210>  3
<211>  619
<212>  DNA
<213>  Homo sapiens

<400>  3
atgaccgcgc cgggcgccgc cgggcgctgc cctcccacga catggctggg ctccctgctg       60

ttgttggtct gtctcctggc gagcaggagt atcaccgagg aggtgtcgga gtactgtagc      120

cacatgattg ggagtggaca cctgcagtct ctgcagcggc tgattgacag tcagatggag      180

acctcgtgcc aaattacatt tgagtttgta gaccaggaac agttgaaaga tccagtgtgc      240

taccttaaga aggcatttct cctggtacaa gacataatgg aggacaccat gcgcttcaga      300

gataacaccc ccaatgccat cgccattgtg cagctgcagg aactctcttt gaggctgaag      360

agctgcttca ccaaggatta tgaagagcat gacaaggcct gcgtccgaac tttctatgag      420

acacctctcc agttgctgga gaaggtcaag aatgtcttta atgaaacaaa gaatctcctt      480

gacaaggact ggaatatttt cagcaagaac tgcaacaaca gctttgctga atgctccagc      540

caaggccatg agaggcagtc cgagggatcc tccagcccgc agctccagga gtctgtcttc      600

cacctgctgg tgcccagtg                                                   619


<210>  4
<211>  1662
<212>  DNA
<213>  Homo sapiens

<400>  4
atgaccgcgc cgggcgccgc cgggcgctgc cctcccacga catggctggg ctccctgctg       60

ttgttggtct gtctcctggc gagcaggagt atcaccgagg aggtgtcgga gtactgtagc      120

cacatgattg ggagtggaca cctgcagtct ctgcagcggc tgattgacag tcagatggag      180

acctcgtgcc aaattacatt tgagtttgta gaccaggaac agttgaaaga tccagtgtgc      240

taccttaaga aggcatttct cctggtacaa gacataatgg aggacaccat gcgcttcaga      300

gataacaccc ccaatgccat cgccattgtg cagctgcagg aactctcttt gaggctgaag      360

agctgcttca ccaaggatta tgaagagcat gacaaggcct gcgtccgaac tttctatgag      420

acacctctcc agttgctgga gaaggtcaag aatgtcttta atgaaacaaa gaatctcctt      480

gacaaggact ggaatatttt cagcaagaac tgcaacaaca gctttgctga atgctccagc      540

caagatgtgg tgaccaagcc tgattgcaac tgcctgtacc ccaaagccat ccctagcagt      600

gacccggcct ctgtctcccc tcatcagccc ctcgccccct ccatggcccc tgtggctggc      660

ttgacctggg aggactctga gggaactgag ggcagctccc tcttgcctgg tgagcagccc      720

ctgcacacag tggatccagg cagtgccaag cagcggccac ccaggagcac ctgccagagc      780

tttgagccgc cagagacccc agttgtcaag gacagcacca tcggtggctc accacagcct      840

cgcccctctg tcggggcctt caaccccggg atggaggata ttcttgactc tgcaatgggc      900

actaattggg tcccagaaga agcctctgga gaggccagtg agattcccgt accccaaggg      960

acagagcttt ccccctccag gccaggaggg ggcagcatgc agacagagcc cgccagaccc     1020

agcaacttcc tctcagcatc ttctccactc cctgcatcag caaagggcca acagccggca     1080

gatgtaactg gtaccgcctt gcccagggtg ggccccgtga ggcccactgg ccaggactgg     1140

aatcacaccc cccagaagac agaccatcca tctgccctgc tcagagaccc cccggagcca     1200

ggctctccca ggatctcatc actgcgcccc cagggcctca gcaacccctc caccctctct     1260

gctcagccac agctttccag aagccactcc tcgggcagcg tgctgcccct tggggagctg     1320

gagggcagga ggagcaccag ggatcggagg agccccgcag agccagaagg aggaccagca     1380

agtgaagggg cagccaggcc cctgccccgt tttaactccg ttcctttgac tgacacaggc     1440

catgagaggc agtccgaggg atcctccagc ccgcagctcc aggagtctgt cttccacctg     1500

ctggtgccca gtgtcatcct ggtcttgctg gccgtcggag gcctcttgtt ctacaggtgg     1560

aggcggcgga gccatcaaga gcctcagaga gcggattctc ccttggagca accagagggc     1620

agccccctga ctcaggatga cagacaggtg gaactgccag tg                        1662


<210>  5
<211>  554
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                 120                 125             


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 
            180                 185                 190         


Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His 
        195                 200                 205             


Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp Glu 
    210                 215                 220                 


Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 
225                 230                 235                 240 


Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
                245                 250                 255     


Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp Ser 
            260                 265                 270         


Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 
        275                 280                 285             


Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 
    290                 295                 300                 


Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 
305                 310                 315                 320 


Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr Glu 
                325                 330                 335     


Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro Ala 
            340                 345                 350         


Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly Thr Ala Leu Pro 
        355                 360                 365             


Arg Val Gly Pro Val Arg Pro Thr Gly Gln Asp Trp Asn His Thr Pro 
    370                 375                 380                 


Gln Lys Thr Asp His Pro Ser Ala Leu Leu Arg Asp Pro Pro Glu Pro 
385                 390                 395                 400 


Gly Ser Pro Arg Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser Asn Pro 
                405                 410                 415     


Ser Thr Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser His Ser Ser Gly 
            420                 425                 430         


Ser Val Leu Pro Leu Gly Glu Leu Glu Gly Arg Arg Ser Thr Arg Asp 
        435                 440                 445             


Arg Arg Ser Pro Ala Glu Pro Glu Gly Gly Pro Ala Ser Glu Gly Ala 
    450                 455                 460                 


Ala Arg Pro Leu Pro Arg Phe Asn Ser Val Pro Leu Thr Asp Thr Gly 
465                 470                 475                 480 


His Glu Arg Gln Ser Glu Gly Ser Ser Ser Pro Gln Leu Gln Glu Ser 
                485                 490                 495     


Val Phe His Leu Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val 
            500                 505                 510         


Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro 
        515                 520                 525             


Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr 
    530                 535                 540                 


Gln Asp Asp Arg Gln Val Glu Leu Pro Val 
545                 550                 


<210>  6
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
1               5                   10                  15      


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
            20                  25                  30          


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
        35                  40                  45              


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
    50                  55                  60                  


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
65                  70                  75                  80  


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
                85                  90                  95      


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
            100                 105                 110         


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
        115                 120                 125             


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
    130                 135                 140                 


Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 
145                 150                 155                 160 


Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His 
                165                 170                 175     


Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp Glu 
            180                 185                 190         


Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 
        195                 200                 205             


Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
    210                 215                 220                 


Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp Ser 
225                 230                 235                 240 


Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 
                245                 250                 255     


Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 
            260                 265                 270         


Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 
        275                 280                 285             


Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr Glu 
    290                 295                 300                 


Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro Ala 
305                 310                 315                 320 


Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly Thr Ala Leu Pro 
                325                 330                 335     


Arg Val Gly Pro Val Arg Pro Thr Gly Gln Asp Trp Asn His Thr Pro 
            340                 345                 350         


Gln Lys Thr Asp His Pro Ser Ala Leu Leu Arg Asp Pro Pro Glu Pro 
        355                 360                 365             


Gly Ser Pro Arg Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser Asn Pro 
    370                 375                 380                 


Ser Thr Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser His Ser Ser Gly 
385                 390                 395                 400 


Ser Val Leu Pro Leu Gly Glu Leu Glu Gly Arg Arg Ser Thr Arg Asp 
                405                 410                 415     


Arg Arg Ser Pro Ala Glu Pro Glu Gly Gly Pro Ala Ser Glu Gly Ala 
            420                 425                 430         


Ala Arg Pro Leu Pro Arg Phe Asn Ser Val Pro Leu Thr Asp Thr Gly 
        435                 440                 445             


His Glu Arg Gln Ser Glu Gly Ser Ser Ser Pro Gln Leu Gln Glu Ser 
    450                 455                 460                 


Val Phe His Leu Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val 
465                 470                 475                 480 


Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro 
                485                 490                 495     


Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr 
            500                 505                 510         


Gln Asp Asp Arg Gln Val Glu Leu Pro Val 
        515                 520         


<210>  7
<211>  438
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                 120                 125             


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 
            180                 185                 190         


Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His 
        195                 200                 205             


Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp Glu 
    210                 215                 220                 


Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 
225                 230                 235                 240 


Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
                245                 250                 255     


Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp Ser 
            260                 265                 270         


Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 
        275                 280                 285             


Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 
    290                 295                 300                 


Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 
305                 310                 315                 320 


Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr Glu 
                325                 330                 335     


Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro Ala 
            340                 345                 350         


Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly His Glu Arg Gln 
        355                 360                 365             


Ser Glu Gly Ser Ser Ser Pro Gln Leu Gln Glu Ser Val Phe His Leu 
    370                 375                 380                 


Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val Gly Gly Leu Leu 
385                 390                 395                 400 


Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro Gln Arg Ala Asp 
                405                 410                 415     


Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr Gln Asp Asp Arg 
            420                 425                 430         


Gln Val Glu Leu Pro Val 
        435             


<210>  8
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
1               5                   10                  15      


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
            20                  25                  30          


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
        35                  40                  45              


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
    50                  55                  60                  


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
65                  70                  75                  80  


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
                85                  90                  95      


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
            100                 105                 110         


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
        115                 120                 125             


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
    130                 135                 140                 


Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 
145                 150                 155                 160 


Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His 
                165                 170                 175     


Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp Glu 
            180                 185                 190         


Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 
        195                 200                 205             


Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
    210                 215                 220                 


Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp Ser 
225                 230                 235                 240 


Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 
                245                 250                 255     


Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 
            260                 265                 270         


Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 
        275                 280                 285             


Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr Glu 
    290                 295                 300                 


Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro Ala 
305                 310                 315                 320 


Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly His Glu Arg Gln 
                325                 330                 335     


Ser Glu Gly Ser Ser Ser Pro Gln Leu Gln Glu Ser Val Phe His Leu 
            340                 345                 350         


Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val Gly Gly Leu Leu 
        355                 360                 365             


Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro Gln Arg Ala Asp 
    370                 375                 380                 


Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr Gln Asp Asp Arg 
385                 390                 395                 400 


Gln Val Glu Leu Pro Val 
                405     


<210>  9
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                 120                 125             


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Glu Cys Ser Ser Gln Gly His Glu Arg Gln Ser Glu Gly Ser Ser Ser 
            180                 185                 190         


Pro Gln Leu Gln Glu Ser Val Phe His Leu Leu Val Pro Ser Val Ile 
        195                 200                 205             


Leu Val Leu Leu Ala Val Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg 
    210                 215                 220                 


Arg Ser His Gln Glu Pro Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Leu Thr Gln Asp Asp Arg Gln Val Glu Leu Pro Val 
                245                 250                 255     


<210>  10
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  10

Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
1               5                   10                  15      


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
            20                  25                  30          


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
        35                  40                  45              


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
    50                  55                  60                  


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
65                  70                  75                  80  


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
                85                  90                  95      


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
            100                 105                 110         


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
        115                 120                 125             


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
    130                 135                 140                 


Glu Cys Ser Ser Gln Gly His Glu Arg Gln Ser Glu Gly Ser Ser Ser 
145                 150                 155                 160 


Pro Gln Leu Gln Glu Ser Val Phe His Leu Leu Val Pro Ser Val Ile 
                165                 170                 175     


Leu Val Leu Leu Ala Val Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg 
            180                 185                 190         


Arg Ser His Gln Glu Pro Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro 
        195                 200                 205             


Glu Gly Ser Pro Leu Thr Gln Asp Asp Arg Gln Val Glu Leu Pro Val 
    210                 215                 220                 


<210>  11
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Lys Lys Thr Gln Thr Trp Ile Leu Thr Cys Ile Tyr Leu Gln Leu 
1               5                   10                  15      


Leu Leu Phe Asn Pro Leu Val Lys Thr Glu Gly Ile Cys Arg Asn Arg 
            20                  25                  30          


Val Thr Asn Asn Val Lys Asp Val Thr Lys Leu Val Ala Asn Leu Pro 
        35                  40                  45              


Lys Asp Tyr Met Ile Thr Leu Lys Tyr Val Pro Gly Met Asp Val Leu 
    50                  55                  60                  


Pro Ser His Cys Trp Ile Ser Glu Met Val Val Gln Leu Ser Asp Ser 
65                  70                  75                  80  


Leu Thr Asp Leu Leu Asp Lys Phe Ser Asn Ile Ser Glu Gly Leu Ser 
                85                  90                  95      


Asn Tyr Ser Ile Ile Asp Lys Leu Val Asn Ile Val Asp Asp Leu Val 
            100                 105                 110         


Glu Cys Val Lys Glu Asn Ser Ser Lys Asp Leu Lys Lys Ser Phe Lys 
        115                 120                 125             


Ser Pro Glu Pro Arg Leu Phe Thr Pro Glu Glu Phe Phe Arg Ile Phe 
    130                 135                 140                 


Asn Arg Ser Ile Asp Ala Phe Lys Asp Phe Val Val Ala Ser Glu Thr 
145                 150                 155                 160 


Ser Asp Cys Val Val Ser Ser Thr Leu Ser Pro Glu Lys Gly Lys Ala 
                165                 170                 175     


Lys Asn Pro Pro Gly Asp Ser Ser Leu His Trp Ala Ala Met Ala Leu 
            180                 185                 190         


Pro Ala Leu Phe Ser Leu Ile Ile Gly Phe Ala Phe Gly Ala Leu Tyr 
        195                 200                 205             


Trp Lys Lys Arg Gln Pro Ser Leu Thr Arg Ala Val Glu Asn Ile Gln 
    210                 215                 220                 


Ile Asn Glu Glu Asp Asn Glu Ile Ser Met Leu Gln Glu Lys Glu Arg 
225                 230                 235                 240 


Glu Phe Gln Glu Val 
                245 


<210>  12
<211>  738
<212>  DNA
<213>  Homo sapiens

<400>  12
atgaagaaga cacaaacttg gattctcact tgcatttatc ttcagctgct cctatttaat       60

cctctcgtca aaactgaagg gatctgcagg aatcgtgtga ctaataatgt aaaagacgtc      120

actaaattgg tggcaaatct tccaaaagac tacatgataa ccctcaaata tgtccccggg      180

atggatgttt tgccaagtca ttgttggata agcgagatgg tagtacaatt gtcagacagc      240

ttgactgatc ttctggacaa gttttcaaat atttctgaag gcttgagtaa ttattccatc      300

atagacaaac ttgtgaatat agtggatgac cttgtggagt gcgtgaaaga aaactcatct      360

aaggatctaa aaaaatcatt caagagccca gaacccaggc tctttactcc tgaagaattc      420

tttagaattt ttaatagatc cattgatgcc ttcaaggact ttgtagtggc atctgaaact      480

agtgattgtg tggtttcttc aacattaagt cctgagaaag ggaaggccaa aaatccccct      540

ggagactcca gcctacactg ggcagccatg gcattgccag cattgttttc tcttataatt      600

ggctttgctt ttggagcctt atactggaag aagagacagc caagtcttac aagggcagtt      660

gaaaatatac aaattaatga agaggataat gagataagta tgttgcaaga gaaagagaga      720

gagtttcaag aagtgtaa                                                    738


<210>  13
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Lys Lys Thr Gln Thr Trp Ile Leu Thr Cys Ile Tyr Leu Gln Leu 
1               5                   10                  15      


Leu Leu Phe Asn Pro Leu Val Lys Thr Glu Gly Ile Cys Arg Asn Arg 
            20                  25                  30          


Val Thr Asn Asn Val Lys Asp Val Thr Lys Leu Val Ala Asn Leu Pro 
        35                  40                  45              


Lys Asp Tyr Met Ile Thr Leu Lys Tyr Val Pro Gly Met Asp Val Leu 
    50                  55                  60                  


Pro Ser His Cys Trp Ile Ser Glu Met Val Val Gln Leu Ser Asp Ser 
65                  70                  75                  80  


Leu Thr Asp Leu Leu Asp Lys Phe Ser Asn Ile Ser Glu Gly Leu Ser 
                85                  90                  95      


Asn Tyr Ser Ile Ile Asp Lys Leu Val Asn Ile Val Asp Asp Leu Val 
            100                 105                 110         


Glu Cys Val Lys Glu Asn Ser Ser Lys Asp Leu Lys Lys Ser Phe Lys 
        115                 120                 125             


Ser Pro Glu Pro Arg Leu Phe Thr Pro Glu Glu Phe Phe Arg Ile Phe 
    130                 135                 140                 


Asn Arg Ser Ile Asp Ala Phe Lys Asp Phe Val Val Ala Ser Glu Thr 
145                 150                 155                 160 


Ser Asp Cys Val Val Ser Ser Thr Leu Ser Pro Glu Lys Asp Ser Arg 
                165                 170                 175     


Val Ser Val Thr Lys Pro Phe Met Leu Pro Pro Val Ala Ala Ser Ser 
            180                 185                 190         


Leu Arg Asn Asp Ser Ser Ser Ser Asn Arg Lys Ala Lys Asn Pro Pro 
        195                 200                 205             


Gly Asp Ser Ser Leu His Trp Ala Ala Met Ala Leu Pro Ala Leu Phe 
    210                 215                 220                 


Ser Leu Ile Ile Gly Phe Ala Phe Gly Ala Leu Tyr Trp Lys Lys Arg 
225                 230                 235                 240 


Gln Pro Ser Leu Thr Arg Ala Val Glu Asn Ile Gln Ile Asn Glu Glu 
                245                 250                 255     


Asp Asn Glu Ile Ser Met Leu Gln Glu Lys Glu Arg Glu Phe Gln Glu 
            260                 265                 270         


Val 
    


<210>  14
<211>  822
<212>  DNA
<213>  Homo sapiens

<400>  14
atgaagaaga cacaaacttg gattctcact tgcatttatc ttcagctgct cctatttaat       60

cctctcgtca aaactgaagg gatctgcagg aatcgtgtga ctaataatgt aaaagacgtc      120

actaaattgg tggcaaatct tccaaaagac tacatgataa ccctcaaata tgtccccggg      180

atggatgttt tgccaagtca ttgttggata agcgagatgg tagtacaatt gtcagacagc      240

ttgactgatc ttctggacaa gttttcaaat atttctgaag gcttgagtaa ttattccatc      300

atagacaaac ttgtgaatat agtggatgac cttgtggagt gcgtgaaaga aaactcatct      360

aaggatctaa aaaaatcatt caagagccca gaacccaggc tctttactcc tgaagaattc      420

tttagaattt ttaatagatc cattgatgcc ttcaaggact ttgtagtggc atctgaaact      480

agtgattgtg tggtttcttc aacattaagt cctgagaaag attccagagt cagtgtcaca      540

aaaccattta tgttaccccc tgttgcagcc agctccctta ggaatgacag cagtagcagt      600

aataggaagg ccaaaaatcc ccctggagac tccagcctac actgggcagc catggcattg      660

ccagcattgt tttctcttat aattggcttt gcttttggag ccttatactg gaagaagaga      720

cagccaagtc ttacaagggc agttgaaaat atacaaatta atgaagagga taatgagata      780

agtatgttgc aagagaaaga gagagagttt caagaagtgt aa                         822


<210>  15
<211>  1405
<212>  DNA
<213>  Homo sapiens

<400>  15
ccgcctcgcg ccgagactag aagcgctgcg ggaagcaggg acagtggaga gggcgctgcg       60

ctcgggctac ccaatgcgtg gactatctgc cgccgctgtt cgtgcaatat gctggagctc      120

cagaacagct aaacggagtc gccacaccac tgtttgtgct ggatcgcagc gctgcctttc      180

cttatgaaga agacacaaac ttggattctc acttgcattt atcttcagct gctcctattt      240

aatcctctcg tcaaaactga agggatctgc aggaatcgtg tgactaataa tgtaaaagac      300

gtcactaaat tggtggcaaa tcttccaaaa gactacatga taaccctcaa atatgtcccc      360

gggatggatg ttttgccaag tcattgttgg ataagcgaga tggtagtaca attgtcagac      420

agcttgactg atcttctgga caagttttca aatatttctg aaggcttgag taattattcc      480

atcatagaca aacttgtgaa tatagtggat gaccttgtgg agtgcgtgaa agaaaactca      540

tctaaggatc taaaaaaatc attcaagagc ccagaaccca ggctctttac tcctgaagaa      600

ttctttagaa tttttaatag atccattgat gccttcaagg actttgtagt ggcatctgaa      660

actagtgatt gtgtggtttc ttcaacatta agtcctgaga aagattccag agtcagtgtc      720

acaaaaccat ttatgttacc ccctgttgca gccagctccc ttaggaatga cagcagtagc      780

agtaatagga aggccaaaaa tccccctgga gactccagcc tacactgggc agccatggca      840

ttgccagcat tgttttctct tataattggc tttgcttttg gagccttata ctggaagaag      900

agacagccaa gtcttacaag ggcagttgaa aatatacaaa ttaatgaaga ggataatgag      960

ataagtatgt tgcaagagaa agagagagag tttcaagaag tgtaaattgt ggcttgtatc     1020

aacactgtta ctttcgtaca ttggctggta acagttcatg tttgcttcat aaatgaagca     1080

gctttaaaca aattcatatt ctgtctggag tgacagacca catctttatc tgttcttgct     1140

acccatgact ttatatggat gattcagaaa ttggaacaga atgttttact gtgaaactgg     1200

cactgaatta atcatctata aagaagaact tgcatggagc aggactctat tttaaggact     1260

gcgggacttg ggtctcattt agaacttgca gctgatgttg gaagagaaag cacgtgtctc     1320

agactgcatg taccatttgc atggctccag aaatgtctaa atgctgaaaa aacacctagc     1380

tttattcttc agatacaaac tgcag                                           1405


<210>  16
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Lys Lys Thr Gln Thr Trp Ile Leu Thr Cys Ile Tyr Leu Gln Leu 
1               5                   10                  15      


Leu Leu Phe Asn Pro Leu Val Lys Thr Glu Gly Ile Cys Arg Asn Arg 
            20                  25                  30          


Val Thr Asn Asn Val Lys Asp Val Thr Lys Leu Val Ala Asn Leu Pro 
        35                  40                  45              


Lys Asp Tyr Met Ile Thr Leu Lys Tyr Val Pro Gly Met Asp Val Leu 
    50                  55                  60                  


Pro Ser His Cys Trp Ile Ser Glu Met Val Val Gln Leu Ser Asp Ser 
65                  70                  75                  80  


Leu Thr Asp Leu Leu Asp Lys Phe Ser Asn Ile Ser Glu Gly Leu Ser 
                85                  90                  95      


Asn Tyr Ser Ile Ile Asp Lys Leu Val Asn Ile Val Asp Asp Leu Val 
            100                 105                 110         


Glu Cys Val Lys Glu Asn Ser Ser Lys Asp Leu Lys Lys Ser Phe Lys 
        115                 120                 125             


Ser Pro Glu Pro Arg Leu Phe Thr Pro Glu Glu Phe Phe Arg Ile Phe 
    130                 135                 140                 


Asn Arg Ser Ile Asp Ala Phe Lys Asp Phe Val Val Ala Ser Glu Thr 
145                 150                 155                 160 


Ser Asp Cys Val Val Ser Ser Thr Leu Ser Pro Glu Lys Asp Ser Arg 
                165                 170                 175     


Val Ser Val Thr Lys Pro Phe Met Leu Pro Pro Val Ala 
            180                 185                 


<210>  17
<211>  567
<212>  DNA
<213>  Homo sapiens

<400>  17
atgaagaaga cacaaacttg gattctcact tgcatttatc ttcagctgct cctatttaat       60

cctctcgtca aaactgaagg gatctgcagg aatcgtgtga ctaataatgt aaaagacgtc      120

actaaattgg tggcaaatct tccaaaagac tacatgataa ccctcaaata tgtccccggg      180

atggatgttt tgccaagtca ttgttggata agcgagatgg tagtacaatt gtcagacagc      240

ttgactgatc ttctggacaa gttttcaaat atttctgaag gcttgagtaa ttattccatc      300

atagacaaac ttgtgaatat agtggatgac cttgtggagt gcgtgaaaga aaactcatct      360

aaggatctaa aaaaatcatt caagagccca gaacccaggc tctttactcc tgaagaattc      420

tttagaattt ttaatagatc cattgatgcc ttcaaggact ttgtagtggc atctgaaact      480

agtgattgtg tggtttcttc aacattaagt cctgagaaag attccagagt cagtgtcaca      540

aaaccattta tgttaccccc tgttgca                                          567


<210>  18
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210>  19
<211>  435
<212>  DNA
<213>  Homo sapiens

<400>  19
atgtggctgc agagcctgct gctcttgggc actgtggcct gcagcatctc tgcacccgcc       60

cgctcgccca gccccagcac gcagccctgg gagcatgtga atgccatcca ggaggcccgg      120

cgtctcctga acctgagtag agacactgct gctgagatga atgaaacagt agaagtcatc      180

tcagaaatgt ttgacctcca ggagccgacc tgcctacaga cccgcctgga gctgtacaag      240

cagggcctgc ggggcagcct caccaagctc aagggcccct tgaccatgat ggccagccac      300

tacaagcagc actgccctcc aaccccggaa acttcctgtg caacccagat tatcaccttt      360

gaaagtttca aagagaacct gaaggacttt ctgcttgtca tcccctttga ctgctgggag      420

ccagtccagg agtga                                                       435


<210>  20
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  20

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125         


<210>  21
<211>  352
<212>  DNA
<213>  Homo sapiens

<400>  21
gccctgggag catgtgaatg ccatccagga ggcccggcgt ctcctgaacc tgagtagaga       60

cactgctgct gagatgaatg aaacagtaga agtcatctca gaaatgtttg acctccagga      120

gccgacctgc ctacagaccc gcctggagct gtacaagcag ggcctgcggg gcagcctcac      180

caagctcaag ggccccttga ccatgatggc cagccactac aagcagcact gccctccaac      240

cccggaaact tcctgtgcaa cccagattat cacctttgaa agtttcaaag agaacctgaa      300

ggactttctg cttgtcatcc cctttgactg ctgggagcca gtccaggagt ga              352


<210>  22
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ser Arg Leu Pro Val Leu Leu Leu Leu Gln Leu Leu Val Arg Pro 
1               5                   10                  15      


Gly Leu Gln Ala Pro Met Thr Gln Thr Thr Pro Leu Lys Thr Ser Trp 
            20                  25                  30          


Val Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln 
        35                  40                  45              


Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln 
    50                  55                  60                  


Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe 
65                  70                  75                  80  


Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile 
                85                  90                  95      


Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr 
            100                 105                 110         


Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg 
        115                 120                 125             


Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln 
    130                 135                 140                 


Thr Thr Leu Ser Leu Ala Ile Phe 
145                 150         


<210>  23
<211>  459
<212>  DNA
<213>  Homo sapiens

<400>  23
atgagccgcc tgcccgtcct gctcctgctc caactcctgg tccgccccgg actccaagct       60

cccatgaccc agacaacgcc cttgaagaca agctgggtta actgctctaa catgatcgat      120

gaaattataa cacacttaaa gcagccacct ttgcctttgc tggacttcaa caacctcaat      180

ggggaagacc aagacattct gatggaaaat aaccttcgaa ggccaaacct ggaggcattc      240

aacagggctg tcaagagttt acagaacgca tcagcaattg agagcattct taaaaatctc      300

ctgccatgtc tgcccctggc cacggccgca cccacgcgac atccaatcca tatcaaggac      360

ggtgactgga atgaattccg gaggaaactg acgttctatc tgaaaaccct tgagaatgcg      420

caggctcaac agacgacttt gagcctcgcg atcttttga                             459


<210>  24
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  24

Ala Pro Met Thr Gln Thr Thr Pro Leu Lys Thr Ser Trp Val Asn Cys 
1               5                   10                  15      


Ser Asn Met Ile Asp Glu Ile Ile Thr His Leu Lys Gln Pro Pro Leu 
            20                  25                  30          


Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp Gln Asp Ile Leu 
        35                  40                  45              


Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala Phe Asn Arg Ala 
    50                  55                  60                  


Val Lys Ser Leu Gln Asn Ala Ser Ala Ile Glu Ser Ile Leu Lys Asn 
65                  70                  75                  80  


Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro Thr Arg His Pro 
                85                  90                  95      


Ile His Ile Lys Asp Gly Asp Trp Asn Glu Phe Arg Arg Lys Leu Thr 
            100                 105                 110         


Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gln Ala Gln Gln Thr Thr Leu 
        115                 120                 125             


Ser Leu Ala Ile Phe 
    130             


<210>  25
<211>  402
<212>  DNA
<213>  Homo sapiens

<400>  25
gctcccatga cccagacaac gcccttgaag acaagctggg ttaactgctc taacatgatc       60

gatgaaatta taacacactt aaagcagcca cctttgcctt tgctggactt caacaacctc      120

aatggggaag accaagacat tctgatggaa aataaccttc gaaggccaaa cctggaggca      180

ttcaacaggg ctgtcaagag tttacagaac gcatcagcaa ttgagagcat tcttaaaaat      240

ctcctgccat gtctgcccct ggccacggcc gcacccacgc gacatccaat ccatatcaag      300

gacggtgact ggaatgaatt ccggaggaaa ctgacgttct atctgaaaac ccttgagaat      360

gcgcaggctc aacagacgac tttgagcctc gcgatctttt ga                         402


