               SEQUENCE LISTING

<110> NESTEC SA

<120> METHODS OF MODULATING FAM46A

<130> 15685

<160> 18

<170> BiSSAP 1.2

<210> 1
<211> 442
<212> PRT
<213> Homo sapiens

<220> 
<223> FAM46 prot SEQ ID NO: 1

<400> 1
Met Ala Glu Gly Glu Gly Tyr Phe Ala Met Ser Glu Asp Glu Leu Ala 
1               5                   10                  15      
Cys Ser Pro Tyr Ile Pro Leu Gly Gly Asp Phe Gly Gly Gly Asp Phe 
            20                  25                  30          
Gly Gly Gly Asp Phe Gly Gly Gly Asp Phe Gly Gly Gly Gly Ser Phe 
        35                  40                  45              
Gly Gly His Cys Leu Asp Tyr Cys Glu Ser Pro Thr Ala His Cys Asn 
    50                  55                  60                  
Val Leu Asn Trp Glu Gln Val Gln Arg Leu Asp Gly Ile Leu Ser Glu 
65                  70                  75                  80  
Thr Ile Pro Ile His Gly Arg Gly Asn Phe Pro Thr Leu Glu Leu Gln 
                85                  90                  95      
Pro Ser Leu Ile Val Lys Val Val Arg Arg Arg Leu Ala Glu Lys Arg 
            100                 105                 110         
Ile Gly Val Arg Asp Val Arg Leu Asn Gly Ser Ala Ala Ser His Val 
        115                 120                 125             
Leu His Gln Asp Ser Gly Leu Gly Tyr Lys Asp Leu Asp Leu Ile Phe 
    130                 135                 140                 
Cys Ala Asp Leu Arg Gly Glu Gly Glu Phe Gln Thr Val Lys Asp Val 
145                 150                 155                 160 
Val Leu Asp Cys Leu Leu Asp Phe Leu Pro Glu Gly Val Asn Lys Glu 
                165                 170                 175     
Lys Ile Thr Pro Leu Thr Leu Lys Glu Ala Tyr Val Gln Lys Met Val 
            180                 185                 190         
Lys Val Cys Asn Asp Ser Asp Arg Trp Ser Leu Ile Ser Leu Ser Asn 
        195                 200                 205             
Asn Ser Gly Lys Asn Val Glu Leu Lys Phe Val Asp Ser Leu Arg Arg 
    210                 215                 220                 
Gln Phe Glu Phe Ser Val Asp Ser Phe Gln Ile Lys Leu Asp Ser Leu 
225                 230                 235                 240 
Leu Leu Phe Tyr Glu Cys Ser Glu Asn Pro Met Thr Glu Thr Phe His 
                245                 250                 255     
Pro Thr Ile Ile Gly Glu Ser Val Tyr Gly Asp Phe Gln Glu Ala Phe 
            260                 265                 270         
Asp His Leu Cys Asn Lys Ile Ile Ala Thr Arg Asn Pro Glu Glu Ile 
        275                 280                 285             
Arg Gly Gly Gly Leu Leu Lys Tyr Cys Asn Leu Leu Val Arg Gly Phe 
    290                 295                 300                 
Arg Pro Ala Ser Asp Glu Ile Lys Thr Leu Gln Arg Tyr Met Cys Ser 
305                 310                 315                 320 
Arg Phe Phe Ile Asp Phe Ser Asp Ile Gly Glu Gln Gln Arg Lys Leu 
                325                 330                 335     
Glu Ser Tyr Leu Gln Asn His Phe Val Gly Leu Glu Asp Arg Lys Tyr 
            340                 345                 350         
Glu Tyr Leu Met Thr Leu His Gly Val Val Asn Glu Ser Thr Val Cys 
        355                 360                 365             
Leu Met Gly His Glu Arg Arg Gln Thr Leu Asn Leu Ile Thr Met Leu 
    370                 375                 380                 
Ala Ile Arg Val Leu Ala Asp Gln Asn Val Ile Pro Asn Val Ala Asn 
385                 390                 395                 400 
Val Thr Cys Tyr Tyr Gln Pro Ala Pro Tyr Val Ala Asp Ala Asn Phe 
                405                 410                 415     
Ser Asn Tyr Tyr Ile Ala Gln Val Gln Pro Val Phe Thr Cys Gln Gln 
            420                 425                 430         
Gln Thr Tyr Ser Thr Trp Leu Pro Cys Asn 
        435                 440         

<210> 2
<211> 1329
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1329
<223> /mol_type="unassigned DNA"
      /note="FAM46 DNA SEQ ID NO: 2"
      /organism="Homo sapiens"

<400> 2
atggcggagg gtgaagggta cttcgccatg tctgaggacg agctggcctg cagcccctac      60

atccccctag gcggcgactt cggcggcggc gacttcggcg gcggcgactt cggcggcggc     120

gacttcggcg gtggcggcag cttcggtggg cattgcttgg actattgcga aagccctacg     180

gcgcactgca atgtgctgaa ctgggagcaa gtgcagcggc tggacggcat cctgagcgag     240

accattccga ttcacgggcg cggcaacttc cccacgctcg agctgcagcc gagcctgatc     300

gtgaaggtgg tgcggcggcg cctggccgag aagcgcattg gcgtccgcga cgtgcgcctc     360

aacggctcgg cagccagcca tgtcctgcac caggacagcg gcctgggcta caaggacctg     420

gacctcatct tctgcgccga cctgcgcggg gaaggggagt ttcagactgt gaaggacgtc     480

gtgctggact gcctgttgga cttcttaccc gagggggtga acaaagagaa gatcacacca     540

ctcacgctca aggaagctta tgtgcagaaa atggttaaag tgtgcaatga ctctgaccga     600

tggagtctta tatccctgtc aaacaacagt ggcaaaaatg tggaactgaa atttgtggat     660

tccctccgga ggcagtttga attcagtgta gattcttttc aaatcaaatt agactctctt     720

ctgctctttt atgaatgttc agagaaccca atgactgaga catttcaccc cacaataatc     780

ggggagagcg tctatggcga tttccaggaa gcctttgatc acctttgtaa caagatcatt     840

gccaccagga acccagagga aatccgaggg ggaggcctgc ttaagtactg caacctcttg     900

gtgaggggct ttaggcccgc ctctgatgaa atcaagaccc ttcaaaggta tatgtgttcc     960

aggtttttca tcgacttctc agacattgga gagcagcaga gaaaactgga gtcctatttg    1020

cagaaccact ttgtgggatt ggaagaccgc aagtatgagt atctcatgac ccttcatgga    1080

gtggtaaatg agagcacagt gtgcctgatg ggacatgaaa gaagacagac tttaaacctt    1140

atcaccatgc tggctatccg ggtgttagct gaccaaaatg tcattcctaa tgtggctaat    1200

gtcacttgct attaccagcc agccccctat gtagcagatg ccaactttag caattactac    1260

attgcacagg ttcagccagt attcacgtgc cagcaacaga cctactccac ttggctaccc    1320

tgcaattaa                                                            1329


<210> 3
<211> 447
<212> PRT
<213> Homo sapiens

<220> 
<223> FAM46 AAH07351.1 SEQ ID NO: 3

<400> 3
Met Ala Glu Gly Glu Gly Tyr Phe Ala Met Ser Glu Asp Glu Leu Ala 
1               5                   10                  15      
Cys Ser Pro Tyr Ile Pro Leu Gly Gly Asp Phe Gly Gly Gly Asp Phe 
            20                  25                  30          
Gly Gly Gly Asp Phe Gly Gly Gly Asp Phe Gly Gly Gly Asp Phe Gly 
        35                  40                  45              
Gly Gly Gly Ser Phe Gly Gly His Cys Leu Asp Tyr Cys Glu Ser Pro 
    50                  55                  60                  
Thr Ala His Cys Asn Val Leu Asn Trp Glu Gln Val Gln Arg Leu Asp 
65                  70                  75                  80  
Gly Ile Leu Ser Glu Thr Ile Pro Ile His Gly Arg Gly Asn Phe Pro 
                85                  90                  95      
Thr Leu Glu Leu Gln Pro Ser Leu Ile Val Lys Val Val Arg Arg Arg 
            100                 105                 110         
Leu Ala Glu Lys Arg Ile Gly Val Arg Asp Val Arg Leu Asn Gly Ser 
        115                 120                 125             
Ala Ala Ser His Val Leu His Gln Asp Ser Gly Leu Gly Tyr Lys Asp 
    130                 135                 140                 
Leu Asp Leu Ile Phe Cys Ala Asp Leu Arg Gly Glu Gly Glu Phe Gln 
145                 150                 155                 160 
Thr Val Lys Asp Val Val Leu Asp Cys Leu Leu Asp Phe Leu Pro Glu 
                165                 170                 175     
Gly Val Asn Lys Glu Lys Ile Thr Pro Leu Thr Leu Lys Glu Ala Tyr 
            180                 185                 190         
Val Gln Lys Met Val Lys Val Cys Asn Asp Ser Asp Arg Trp Ser Leu 
        195                 200                 205             
Ile Ser Leu Ser Asn Asn Ser Gly Lys Asn Val Glu Leu Lys Phe Val 
    210                 215                 220                 
Asp Ser Leu Arg Arg Gln Phe Glu Phe Ser Val Asp Ser Phe Gln Ile 
225                 230                 235                 240 
Lys Leu Asp Ser Leu Leu Leu Phe Tyr Glu Cys Ser Glu Asn Pro Met 
                245                 250                 255     
Thr Glu Thr Phe His Pro Thr Ile Ile Gly Glu Ser Val Tyr Gly Asp 
            260                 265                 270         
Phe Gln Glu Ala Phe Asp His Leu Cys Asn Lys Ile Ile Ala Thr Arg 
        275                 280                 285             
Asn Pro Glu Glu Ile Arg Gly Gly Gly Leu Leu Lys Tyr Cys Asn Leu 
    290                 295                 300                 
Leu Val Arg Gly Phe Arg Pro Ala Ser Asp Glu Ile Lys Thr Leu Gln 
305                 310                 315                 320 
Arg Tyr Met Cys Ser Arg Phe Phe Ile Asp Phe Ser Asp Ile Gly Glu 
                325                 330                 335     
Gln Gln Arg Lys Leu Glu Ser Tyr Leu Gln Asn His Phe Val Gly Leu 
            340                 345                 350         
Glu Asp Arg Lys Tyr Glu Tyr Leu Met Thr Leu His Gly Val Val Asn 
        355                 360                 365             
Glu Ser Thr Val Cys Leu Met Gly His Glu Arg Arg Gln Thr Leu Asn 
    370                 375                 380                 
Leu Ile Thr Met Leu Ala Ile Arg Val Leu Ala Asp Gln Asn Val Ile 
385                 390                 395                 400 
Pro Asn Val Ala Asn Val Thr Cys Tyr Tyr Gln Pro Ala Pro Tyr Val 
                405                 410                 415     
Ala Asp Ala Asn Phe Ser Asn Tyr Tyr Ile Ala Gln Val Gln Pro Val 
            420                 425                 430         
Phe Thr Cys Gln Gln Gln Thr Tyr Ser Thr Trp Leu Pro Cys Asn 
        435                 440                 445         

<210> 4
<211> 1344
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..1344
<223> /mol_type="unassigned DNA"
      /note="FAM46A BC007351.2 SEQ ID NO:4"
      /organism="Homo sapiens"

<400> 4
atggcggagg gtgaagggta cttcgccatg tctgaggacg agctggcctg cagcccctac      60

atccccctag gcggcgactt cggcggcggc gacttcggcg gcggcgactt cggcggcggc     120

gacttcggcg gcggcgactt cggcggtggc ggcagcttcg gtgggcattg cttggactat     180

tgcgaaagcc ctacggcgca ctgcaatgtg ctgaactggg agcaagtgca gcggctggac     240

ggcatcctga gcgagaccat tccgattcac gggcgcggca acttccccac gctcgagctg     300

cagccgagcc tgatcgtgaa ggtggtgcgg cggcgcctgg ccgagaagcg cattggcgtc     360

cgcgacgtgc gcctcaacgg ctcggcagcc agccatgtcc tgcaccagga cagcggcctg     420

ggctacaagg acctggacct catcttctgc gccgacctgc gcggggaagg ggagtttcag     480

actgtgaagg acgtcgtgct ggactgcctg ttggacttct tacccgaggg ggtgaacaaa     540

gagaagatca caccactcac gctcaaggaa gcttatgtgc agaaaatggt taaagtgtgc     600

aatgactctg accgatggag tcttatatcc ctgtcaaaca acagtggcaa aaatgtggaa     660

ctgaaatttg tggattccct ccggaggcag tttgaattca gtgtagattc ttttcaaatc     720

aaattagact ctcttctgct cttttatgaa tgttcagaga acccaatgac tgagacattt     780

caccccacaa taatcgggga gagcgtctat ggcgatttcc aggaagcctt tgatcacctt     840

tgtaacaaga tcattgccac caggaaccca gaggaaatcc gagggggagg cctgcttaag     900

tactgcaacc tcttggtgag gggctttagg cccgcctctg atgaaatcaa gacccttcaa     960

aggtatatgt gttccaggtt tttcatcgac ttctcagaca ttggagagca gcagagaaaa    1020

ctggagtcct atttgcagaa ccactttgtg ggattggaag accgcaagta tgagtatctc    1080

atgacccttc atggagtggt aaatgagagc acagtgtgcc tgatgggaca tgaaagaaga    1140

cagactttaa accttatcac catgctggct atccgggtgt tagctgacca aaatgtcatt    1200

cctaatgtgg ctaatgtcac ttgctattac cagccagccc cctatgtagc agatgccaac    1260

tttagcaatt actacattgc acaggttcag ccagtattca cgtgccagca acagacctac    1320

tccacttggc taccctgcaa ttaa                                           1344


<210> 5
<211> 167
<212> PRT
<213> Homo sapiens

<220> 
<223> Leptin NP_000221.1 SEQ ID NO:5

<400> 5
Met His Trp Gly Thr Leu Cys Gly Phe Leu Trp Leu Trp Pro Tyr Leu 
1               5                   10                  15      
Phe Tyr Val Gln Ala Val Pro Ile Gln Lys Val Gln Asp Asp Thr Lys 
            20                  25                  30          
Thr Leu Ile Lys Thr Ile Val Thr Arg Ile Asn Asp Ile Ser His Thr 
        35                  40                  45              
Gln Ser Val Ser Ser Lys Gln Lys Val Thr Gly Leu Asp Phe Ile Pro 
    50                  55                  60                  
Gly Leu His Pro Ile Leu Thr Leu Ser Lys Met Asp Gln Thr Leu Ala 
65                  70                  75                  80  
Val Tyr Gln Gln Ile Leu Thr Ser Met Pro Ser Arg Asn Val Ile Gln 
                85                  90                  95      
Ile Ser Asn Asp Leu Glu Asn Leu Arg Asp Leu Leu His Val Leu Ala 
            100                 105                 110         
Phe Ser Lys Ser Cys His Leu Pro Trp Ala Ser Gly Leu Glu Thr Leu 
        115                 120                 125             
Asp Ser Leu Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val 
    130                 135                 140                 
Val Ala Leu Ser Arg Leu Gln Gly Ser Leu Gln Asp Met Leu Trp Gln 
145                 150                 155                 160 
Leu Asp Leu Ser Pro Gly Cys 
                165         

<210> 6
<211> 504
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..504
<223> /mol_type="unassigned DNA"
      /note="Leptin NM_000230.2 SEQ ID NO:6"
      /organism="Homo sapiens"

<400> 6
atgcattggg gaaccctgtg cggattcttg tggctttggc cctatctttt ctatgtccaa      60

gctgtgccca tccaaaaagt ccaagatgac accaaaaccc tcatcaagac aattgtcacc     120

aggatcaatg acatttcaca cacgcagtca gtctcctcca aacagaaagt caccggtttg     180

gacttcattc ctgggctcca ccccatcctg accttatcca agatggacca gacactggca     240

gtctaccaac agatcctcac cagtatgcct tccagaaacg tgatccaaat atccaacgac     300

ctggagaacc tccgggatct tcttcacgtg ctggccttct ctaagagctg ccacttgccc     360

tgggccagtg gcctggagac cttggacagc ctggggggtg tcctggaagc ttcaggctac     420

tccacagagg tggtggccct gagcaggctg caggggtctc tgcaggacat gctgtggcag     480

ctggacctca gccctgggtg ctga                                            504


<210> 7
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 7
tggtgtgcac aggagccaag                                                20


<210> 8
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 8
ttcacatcac agctccccac                                                20


<210> 9
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 9
ggctttggcc ctatcttttc                                                20


<210> 10
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 10
accggtgact ttctgtttgg                                                20


<210> 11
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 11
caacagtggc aaaaatgtgg                                                20


<210> 12
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 12
tcctggaaat cgccatagac                                                20


<210> 13
<211> 23
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..23
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 13
gatccagtgg ttgcagatta caa                                            23


<210> 14
<211> 21
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..21
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 14
gagggagttg gaaggctctt c                                              21


<210> 15
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 15
tggacaagaa cagcaacgag                                                20


<210> 16
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..20
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 16
ttgtcactgg tcagctccag                                                20


<210> 17
<211> 18
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..18
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 17
ggccgtgatg gcagagat                                                  18


<210> 18
<211> 17
<212> DNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..17
<223> /mol_type="unassigned DNA"
      /organism="Homo sapiens"

<400> 18
ccttcagccc gggtact                                                   17


16:10 28/11/2017