                         SEQUENCE LISTING

<110>  The Wistar Institute of Anatomy and Biology
       Weiner, David B.
       Muthumani, Kar
 
<120>  FOOT AND MOUTH DISEASE VIRUS SEROTYPE O (FMDV-O) VACCINE

<130>  206193-0002-00-WO.606898

<150>  US 62/425,388
<151>  2016-11-22

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  639
<212>  DNA
<213>  artificial sequence

<220>
<223>  nucleotide sequence encoding consensus FMDV-O VP1

<400>  1
accacctcca ccggagagtc cgccgaccca gtgaccgcca ccgtggagaa ctacggcggc       60

gagacacagg tgcagcggcg ccagcacacc gacgtgagct tcatcctgga ccggttcgtg      120

aaggtgaccc caaaggacca gatcaacgtg ctggacctga tgcagatccc tgcacacacc      180

ctggtgggcg ccctgctgag gaccgccacc tactacttcg ccgacctgga ggtggccgtg      240

aagcacgagg gcaacctgac ctgggtgcct aacggagcac cagaggccgc cctggacaac      300

accaccaacc caaccgcata ccacaaggcc cctctgacca ggctggccct gccatacacc      360

gcccctcaca gggtgctggc aaccgtgtac aacggcaact gcaagtacgg agagtcccct      420

gtgaccaacg tgcgcggcga cctgcaggtg ctggcacaga aggcagcaag gaccctgccc      480

accagcttca actacggcgc catcaaggcc accagggtga ccgagctgct gtacagaatg      540

aagcgggccg agacatactg tcccagacca ctgctggcaa tccacccttc cgaggcaagg      600

cacaagcaga agatcgtggc accagtgaag cagctgctg                             639


<210>  2
<211>  213
<212>  PRT
<213>  artificial sequence

<220>
<223>  amino acid sequence for consensus FMDV-O VP1

<400>  2

Thr Thr Ser Thr Gly Glu Ser Ala Asp Pro Val Thr Ala Thr Val Glu 
1               5                   10                  15      


Asn Tyr Gly Gly Glu Thr Gln Val Gln Arg Arg Gln His Thr Asp Val 
            20                  25                  30          


Ser Phe Ile Leu Asp Arg Phe Val Lys Val Thr Pro Lys Asp Gln Ile 
        35                  40                  45              


Asn Val Leu Asp Leu Met Gln Ile Pro Ala His Thr Leu Val Gly Ala 
    50                  55                  60                  


Leu Leu Arg Thr Ala Thr Tyr Tyr Phe Ala Asp Leu Glu Val Ala Val 
65                  70                  75                  80  


Lys His Glu Gly Asn Leu Thr Trp Val Pro Asn Gly Ala Pro Glu Ala 
                85                  90                  95      


Ala Leu Asp Asn Thr Thr Asn Pro Thr Ala Tyr His Lys Ala Pro Leu 
            100                 105                 110         


Thr Arg Leu Ala Leu Pro Tyr Thr Ala Pro His Arg Val Leu Ala Thr 
        115                 120                 125             


Val Tyr Asn Gly Asn Cys Lys Tyr Gly Glu Ser Pro Val Thr Asn Val 
    130                 135                 140                 


Arg Gly Asp Leu Gln Val Leu Ala Gln Lys Ala Ala Arg Thr Leu Pro 
145                 150                 155                 160 


Thr Ser Phe Asn Tyr Gly Ala Ile Lys Ala Thr Arg Val Thr Glu Leu 
                165                 170                 175     


Leu Tyr Arg Met Lys Arg Ala Glu Thr Tyr Cys Pro Arg Pro Leu Leu 
            180                 185                 190         


Ala Ile His Pro Ser Glu Ala Arg His Lys Gln Lys Ile Val Ala Pro 
        195                 200                 205             


Val Lys Gln Leu Leu 
    210             


<210>  3
<211>  654
<212>  DNA
<213>  artificial sequence

<220>
<223>  nucleotide sequence encoding consensus FMDV-O VP2

<400>  3
gacaagaaga ccgaggagac aaccctgctg gaggaccgca tcctgaccac caggaacggc       60

cacaccacca gcaccaccca gagctccgtg ggagtgacct acggatacgc aaccgcagag      120

gacttcgtga gcggaccaaa cacctccggc ctggagacaa gggtggtgca ggcagagcgg      180

ttcttcaaga cccacctgtt cgactgggtg acctccgacc ctttcggcag gtgctacctg      240

ctggagctgc ccaccgacca caagggcgtg tacggcagcc tgaccgactc ctacgcctac      300

atgagaaacg gatgggacgt ggaggtgacc gcagtgggaa accagttcaa cggcggatgc      360

ctgctggtgg caatggtgcc cgagctgtgc agcatcgaca agagagagct gtaccagctg      420

accctgttcc ctcaccagtt catcaacccc cggaccaaca tgaccgcaca catcaccgtg      480

cccttcgtgg gagtgaaccg ctacgaccag tacaaggtgc acaagccatg gaccctggtg      540

gtcatggtgg tggccccact gaccgtgaac accgagggag ccccacagat caaggtgtac      600

gccaacatcg caccaaccaa cgtgcacgtg gcaggagagt tccctagcaa ggag            654


<210>  4
<211>  218
<212>  PRT
<213>  artificial sequence

<220>
<223>  amino acid sequence for consensus FMDV-O VP2

<400>  4

Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp Arg Ile Leu Thr 
1               5                   10                  15      


Thr Arg Asn Gly His Thr Thr Ser Thr Thr Gln Ser Ser Val Gly Val 
            20                  25                  30          


Thr Tyr Gly Tyr Ala Thr Ala Glu Asp Phe Val Ser Gly Pro Asn Thr 
        35                  40                  45              


Ser Gly Leu Glu Thr Arg Val Val Gln Ala Glu Arg Phe Phe Lys Thr 
    50                  55                  60                  


His Leu Phe Asp Trp Val Thr Ser Asp Pro Phe Gly Arg Cys Tyr Leu 
65                  70                  75                  80  


Leu Glu Leu Pro Thr Asp His Lys Gly Val Tyr Gly Ser Leu Thr Asp 
                85                  90                  95      


Ser Tyr Ala Tyr Met Arg Asn Gly Trp Asp Val Glu Val Thr Ala Val 
            100                 105                 110         


Gly Asn Gln Phe Asn Gly Gly Cys Leu Leu Val Ala Met Val Pro Glu 
        115                 120                 125             


Leu Cys Ser Ile Asp Lys Arg Glu Leu Tyr Gln Leu Thr Leu Phe Pro 
    130                 135                 140                 


His Gln Phe Ile Asn Pro Arg Thr Asn Met Thr Ala His Ile Thr Val 
145                 150                 155                 160 


Pro Phe Val Gly Val Asn Arg Tyr Asp Gln Tyr Lys Val His Lys Pro 
                165                 170                 175     


Trp Thr Leu Val Val Met Val Val Ala Pro Leu Thr Val Asn Thr Glu 
            180                 185                 190         


Gly Ala Pro Gln Ile Lys Val Tyr Ala Asn Ile Ala Pro Thr Asn Val 
        195                 200                 205             


His Val Ala Gly Glu Phe Pro Ser Lys Glu 
    210                 215             


<210>  5
<211>  660
<212>  DNA
<213>  artificial sequence

<220>
<223>  nucleotide sequence encoding consensus FMDV-O VP3

<400>  5
ggaatcttcc ctgtggcatg cagcgacgga tacggcggcc tggtgaccac cgaccccaag       60

accgccgacc cagtgtacgg caaggtgttc aacccaccca ggaacctgct gcccggcagg      120

ttcaccaacc tgctggacgt ggcagaggca tgtcccacct tcctgcactt cgacggcgac      180

gtgccatacg tgaccaccaa gaccgactcc gacagggtgc tggcacagtt cgacctgtcc      240

ctggcagcca agcacatgag caacaccttc ctggccggcc tggcccagta ctacacccag      300

tacagcggca ccatcaacct gcacttcatg ttcaccggcc caaccgacgc caaggccaga      360

tacatggtgg catacgcccc tcccggaatg gagccaccta agacccctga ggcagcagca      420

cactgcatcc acgccgagtg ggacaccggc ctgaacagca agttcacctt ctccatcccc      480

tacctgagcg ccgcagacta cgcatacacc gcatccgacg tggcagagac aaccaacgtg      540

cagggctggg tgtgcctgtt ccagatcacc cacggcaagg cagacggcga cgcactggtg      600

gtgctggcca gcgccggcaa ggacttcgac ctgagactgc cagtggacgc aaggacccag      660


<210>  6
<211>  220
<212>  PRT
<213>  artificial sequence

<220>
<223>  amino acid sequence for consensus FMDV-O VP3

<400>  6

Gly Ile Phe Pro Val Ala Cys Ser Asp Gly Tyr Gly Gly Leu Val Thr 
1               5                   10                  15      


Thr Asp Pro Lys Thr Ala Asp Pro Val Tyr Gly Lys Val Phe Asn Pro 
            20                  25                  30          


Pro Arg Asn Leu Leu Pro Gly Arg Phe Thr Asn Leu Leu Asp Val Ala 
        35                  40                  45              


Glu Ala Cys Pro Thr Phe Leu His Phe Asp Gly Asp Val Pro Tyr Val 
    50                  55                  60                  


Thr Thr Lys Thr Asp Ser Asp Arg Val Leu Ala Gln Phe Asp Leu Ser 
65                  70                  75                  80  


Leu Ala Ala Lys His Met Ser Asn Thr Phe Leu Ala Gly Leu Ala Gln 
                85                  90                  95      


Tyr Tyr Thr Gln Tyr Ser Gly Thr Ile Asn Leu His Phe Met Phe Thr 
            100                 105                 110         


Gly Pro Thr Asp Ala Lys Ala Arg Tyr Met Val Ala Tyr Ala Pro Pro 
        115                 120                 125             


Gly Met Glu Pro Pro Lys Thr Pro Glu Ala Ala Ala His Cys Ile His 
    130                 135                 140                 


Ala Glu Trp Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Ser Ile Pro 
145                 150                 155                 160 


Tyr Leu Ser Ala Ala Asp Tyr Ala Tyr Thr Ala Ser Asp Val Ala Glu 
                165                 170                 175     


Thr Thr Asn Val Gln Gly Trp Val Cys Leu Phe Gln Ile Thr His Gly 
            180                 185                 190         


Lys Ala Asp Gly Asp Ala Leu Val Val Leu Ala Ser Ala Gly Lys Asp 
        195                 200                 205             


Phe Asp Leu Arg Leu Pro Val Asp Ala Arg Thr Gln 
    210                 215                 220 


<210>  7
<211>  219
<212>  DNA
<213>  artificial sequence

<220>
<223>  nucleotide sequence encoding consensus FMDV-O VP4

<400>  7
ggggcagggc agtcatctcc cgcaacttgg tcacagaacc agagcggcaa caccggctcc       60

atcatcaaca actactacat gcagcagtac cagaactcca tggacaccca gctgggcgac      120

aacgccacca gcggcggctc caacgagggc agcaccgaca ccacctccac ccacaccacc      180

aacacccaga acaacgactg gttcagcaag ctggcctcc                             219


<210>  8
<211>  73
<212>  PRT
<213>  artificial sequence

<220>
<223>  amino acid sequence for consensus FMDV-O VP4

<400>  8

Gly Ala Gly Gln Ser Ser Pro Ala Thr Trp Ser Gln Asn Gln Ser Gly 
1               5                   10                  15      


Asn Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln Asn 
            20                  25                  30          


Ser Met Asp Thr Gln Leu Gly Asp Asn Ala Thr Ser Gly Gly Ser Asn 
        35                  40                  45              


Glu Gly Ser Thr Asp Thr Thr Ser Thr His Thr Thr Asn Thr Gln Asn 
    50                  55                  60                  


Asn Asp Trp Phe Ser Lys Leu Ala Ser 
65                  70              


<210>  9
<211>  54
<212>  DNA
<213>  artificial sequence

<220>
<223>  nucleotide sequence encoding 2A

<400>  9
accctgaact tcgacctcct caaactggct ggcgatgtgg aaagcaatcc tgga             54


<210>  10
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  amino acid sequence for 2A

<400>  10

Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly 
        


<210>  11
<211>  2238
<212>  DNA
<213>  artificial sequence

<220>
<223>  Nucleotide sequence encoding synthetic consensus FMDV-O 
       comprising VP4, VP2, VP3, and VP1

<400>  11
atgggggcag ggcagtcatc tcccgcaact tggtcacaga accagagcgg caacaccggc       60

tccatcatca acaactacta catgcagcag taccagaact ccatggacac ccagctgggc      120

gacaacgcca ccagcggcgg ctccaacgag ggcagcaccg acaccacctc cacccacacc      180

accaacaccc agaacaacga ctggttcagc aagctggcct ccaggggcag aaagaggaga      240

tccgacaaga agaccgagga gacaaccctg ctggaggacc gcatcctgac caccaggaac      300

ggccacacca ccagcaccac ccagagctcc gtgggagtga cctacggata cgcaaccgca      360

gaggacttcg tgagcggacc aaacacctcc ggcctggaga caagggtggt gcaggcagag      420

cggttcttca agacccacct gttcgactgg gtgacctccg accctttcgg caggtgctac      480

ctgctggagc tgcccaccga ccacaagggc gtgtacggca gcctgaccga ctcctacgcc      540

tacatgagaa acggatggga cgtggaggtg accgcagtgg gaaaccagtt caacggcgga      600

tgcctgctgg tggcaatggt gcccgagctg tgcagcatcg acaagagaga gctgtaccag      660

ctgaccctgt tccctcacca gttcatcaac ccccggacca acatgaccgc acacatcacc      720

gtgcccttcg tgggagtgaa ccgctacgac cagtacaagg tgcacaagcc atggaccctg      780

gtggtcatgg tggtggcccc actgaccgtg aacaccgagg gagccccaca gatcaaggtg      840

tacgccaaca tcgcaccaac caacgtgcac gtggcaggag agttccctag caaggagagg      900

ggaaggaagc ggcgctccgg aatcttccct gtggcatgca gcgacggata cggcggcctg      960

gtgaccaccg accccaagac cgccgaccca gtgtacggca aggtgttcaa cccacccagg     1020

aacctgctgc ccggcaggtt caccaacctg ctggacgtgg cagaggcatg tcccaccttc     1080

ctgcacttcg acggcgacgt gccatacgtg accaccaaga ccgactccga cagggtgctg     1140

gcacagttcg acctgtccct ggcagccaag cacatgagca acaccttcct ggccggcctg     1200

gcccagtact acacccagta cagcggcacc atcaacctgc acttcatgtt caccggccca     1260

accgacgcca aggccagata catggtggca tacgcccctc ccggaatgga gccacctaag     1320

acccctgagg cagcagcaca ctgcatccac gccgagtggg acaccggcct gaacagcaag     1380

ttcaccttct ccatccccta cctgagcgcc gcagactacg catacaccgc atccgacgtg     1440

gcagagacaa ccaacgtgca gggctgggtg tgcctgttcc agatcaccca cggcaaggca     1500

gacggcgacg cactggtggt gctggccagc gccggcaagg acttcgacct gagactgcca     1560

gtggacgcaa ggacccagag gggaagaaag aggagaagca ccacctccac cggagagtcc     1620

gccgacccag tgaccgccac cgtggagaac tacggcggcg agacacaggt gcagcggcgc     1680

cagcacaccg acgtgagctt catcctggac cggttcgtga aggtgacccc aaaggaccag     1740

atcaacgtgc tggacctgat gcagatccct gcacacaccc tggtgggcgc cctgctgagg     1800

accgccacct actacttcgc cgacctggag gtggccgtga agcacgaggg caacctgacc     1860

tgggtgccta acggagcacc agaggccgcc ctggacaaca ccaccaaccc aaccgcatac     1920

cacaaggccc ctctgaccag gctggccctg ccatacaccg cccctcacag ggtgctggca     1980

accgtgtaca acggcaactg caagtacgga gagtcccctg tgaccaacgt gcgcggcgac     2040

ctgcaggtgc tggcacagaa ggcagcaagg accctgccca ccagcttcaa ctacggcgcc     2100

atcaaggcca ccagggtgac cgagctgctg tacagaatga agcgggccga gacatactgt     2160

cccagaccac tgctggcaat ccacccttcc gaggcaaggc acaagcagaa gatcgtggca     2220

ccagtgaagc agctgctg                                                   2238


<210>  12
<211>  746
<212>  PRT
<213>  artificial sequence

<220>
<223>  Amino acid sequence of synthetic consensus FMDV-O comprising VP4,
       VP2, VP3, and VP1

<400>  12

Met Gly Ala Gly Gln Ser Ser Pro Ala Thr Trp Ser Gln Asn Gln Ser 
1               5                   10                  15      


Gly Asn Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr Gln 
            20                  25                  30          


Asn Ser Met Asp Thr Gln Leu Gly Asp Asn Ala Thr Ser Gly Gly Ser 
        35                  40                  45              


Asn Glu Gly Ser Thr Asp Thr Thr Ser Thr His Thr Thr Asn Thr Gln 
    50                  55                  60                  


Asn Asn Asp Trp Phe Ser Lys Leu Ala Ser Arg Gly Arg Lys Arg Arg 
65                  70                  75                  80  


Ser Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp Arg Ile Leu 
                85                  90                  95      


Thr Thr Arg Asn Gly His Thr Thr Ser Thr Thr Gln Ser Ser Val Gly 
            100                 105                 110         


Val Thr Tyr Gly Tyr Ala Thr Ala Glu Asp Phe Val Ser Gly Pro Asn 
        115                 120                 125             


Thr Ser Gly Leu Glu Thr Arg Val Val Gln Ala Glu Arg Phe Phe Lys 
    130                 135                 140                 


Thr His Leu Phe Asp Trp Val Thr Ser Asp Pro Phe Gly Arg Cys Tyr 
145                 150                 155                 160 


Leu Leu Glu Leu Pro Thr Asp His Lys Gly Val Tyr Gly Ser Leu Thr 
                165                 170                 175     


Asp Ser Tyr Ala Tyr Met Arg Asn Gly Trp Asp Val Glu Val Thr Ala 
            180                 185                 190         


Val Gly Asn Gln Phe Asn Gly Gly Cys Leu Leu Val Ala Met Val Pro 
        195                 200                 205             


Glu Leu Cys Ser Ile Asp Lys Arg Glu Leu Tyr Gln Leu Thr Leu Phe 
    210                 215                 220                 


Pro His Gln Phe Ile Asn Pro Arg Thr Asn Met Thr Ala His Ile Thr 
225                 230                 235                 240 


Val Pro Phe Val Gly Val Asn Arg Tyr Asp Gln Tyr Lys Val His Lys 
                245                 250                 255     


Pro Trp Thr Leu Val Val Met Val Val Ala Pro Leu Thr Val Asn Thr 
            260                 265                 270         


Glu Gly Ala Pro Gln Ile Lys Val Tyr Ala Asn Ile Ala Pro Thr Asn 
        275                 280                 285             


Val His Val Ala Gly Glu Phe Pro Ser Lys Glu Arg Gly Arg Lys Arg 
    290                 295                 300                 


Arg Ser Gly Ile Phe Pro Val Ala Cys Ser Asp Gly Tyr Gly Gly Leu 
305                 310                 315                 320 


Val Thr Thr Asp Pro Lys Thr Ala Asp Pro Val Tyr Gly Lys Val Phe 
                325                 330                 335     


Asn Pro Pro Arg Asn Leu Leu Pro Gly Arg Phe Thr Asn Leu Leu Asp 
            340                 345                 350         


Val Ala Glu Ala Cys Pro Thr Phe Leu His Phe Asp Gly Asp Val Pro 
        355                 360                 365             


Tyr Val Thr Thr Lys Thr Asp Ser Asp Arg Val Leu Ala Gln Phe Asp 
    370                 375                 380                 


Leu Ser Leu Ala Ala Lys His Met Ser Asn Thr Phe Leu Ala Gly Leu 
385                 390                 395                 400 


Ala Gln Tyr Tyr Thr Gln Tyr Ser Gly Thr Ile Asn Leu His Phe Met 
                405                 410                 415     


Phe Thr Gly Pro Thr Asp Ala Lys Ala Arg Tyr Met Val Ala Tyr Ala 
            420                 425                 430         


Pro Pro Gly Met Glu Pro Pro Lys Thr Pro Glu Ala Ala Ala His Cys 
        435                 440                 445             


Ile His Ala Glu Trp Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe Ser 
    450                 455                 460                 


Ile Pro Tyr Leu Ser Ala Ala Asp Tyr Ala Tyr Thr Ala Ser Asp Val 
465                 470                 475                 480 


Ala Glu Thr Thr Asn Val Gln Gly Trp Val Cys Leu Phe Gln Ile Thr 
                485                 490                 495     


His Gly Lys Ala Asp Gly Asp Ala Leu Val Val Leu Ala Ser Ala Gly 
            500                 505                 510         


Lys Asp Phe Asp Leu Arg Leu Pro Val Asp Ala Arg Thr Gln Arg Gly 
        515                 520                 525             


Arg Lys Arg Arg Ser Thr Thr Ser Thr Gly Glu Ser Ala Asp Pro Val 
    530                 535                 540                 


Thr Ala Thr Val Glu Asn Tyr Gly Gly Glu Thr Gln Val Gln Arg Arg 
545                 550                 555                 560 


Gln His Thr Asp Val Ser Phe Ile Leu Asp Arg Phe Val Lys Val Thr 
                565                 570                 575     


Pro Lys Asp Gln Ile Asn Val Leu Asp Leu Met Gln Ile Pro Ala His 
            580                 585                 590         


Thr Leu Val Gly Ala Leu Leu Arg Thr Ala Thr Tyr Tyr Phe Ala Asp 
        595                 600                 605             


Leu Glu Val Ala Val Lys His Glu Gly Asn Leu Thr Trp Val Pro Asn 
    610                 615                 620                 


Gly Ala Pro Glu Ala Ala Leu Asp Asn Thr Thr Asn Pro Thr Ala Tyr 
625                 630                 635                 640 


His Lys Ala Pro Leu Thr Arg Leu Ala Leu Pro Tyr Thr Ala Pro His 
                645                 650                 655     


Arg Val Leu Ala Thr Val Tyr Asn Gly Asn Cys Lys Tyr Gly Glu Ser 
            660                 665                 670         


Pro Val Thr Asn Val Arg Gly Asp Leu Gln Val Leu Ala Gln Lys Ala 
        675                 680                 685             


Ala Arg Thr Leu Pro Thr Ser Phe Asn Tyr Gly Ala Ile Lys Ala Thr 
    690                 695                 700                 


Arg Val Thr Glu Leu Leu Tyr Arg Met Lys Arg Ala Glu Thr Tyr Cys 
705                 710                 715                 720 


Pro Arg Pro Leu Leu Ala Ile His Pro Ser Glu Ala Arg His Lys Gln 
                725                 730                 735     


Lys Ile Val Ala Pro Val Lys Gln Leu Leu 
            740                 745     


<210>  13
<211>  2364
<212>  DNA
<213>  artificial sequence

<220>
<223>  Nucleotide sequence encoding synthetic consensus FMDV-O 
       comprising VP4, VP2, VP3, and VP1 operably linked to nucleotide 
       sequence encoding an IgE leader sequence

<400>  13
atggattgga catggattct gttcctcgtc gccgccgcca ctagggtgca ttctggggca       60

gggcagtcat ctcccgcaac ttggtcacag aaccagagcg gcaacaccgg ctccatcatc      120

aacaactact acatgcagca gtaccagaac tccatggaca cccagctggg cgacaacgcc      180

accagcggcg gctccaacga gggcagcacc gacaccacct ccacccacac caccaacacc      240

cagaacaacg actggttcag caagctggcc tccaggggca gaaagaggag atccgacaag      300

aagaccgagg agacaaccct gctggaggac cgcatcctga ccaccaggaa cggccacacc      360

accagcacca cccagagctc cgtgggagtg acctacggat acgcaaccgc agaggacttc      420

gtgagcggac caaacacctc cggcctggag acaagggtgg tgcaggcaga gcggttcttc      480

aagacccacc tgttcgactg ggtgacctcc gaccctttcg gcaggtgcta cctgctggag      540

ctgcccaccg accacaaggg cgtgtacggc agcctgaccg actcctacgc ctacatgaga      600

aacggatggg acgtggaggt gaccgcagtg ggaaaccagt tcaacggcgg atgcctgctg      660

gtggcaatgg tgcccgagct gtgcagcatc gacaagagag agctgtacca gctgaccctg      720

ttccctcacc agttcatcaa cccccggacc aacatgaccg cacacatcac cgtgcccttc      780

gtgggagtga accgctacga ccagtacaag gtgcacaagc catggaccct ggtggtcatg      840

gtggtggccc cactgaccgt gaacaccgag ggagccccac agatcaaggt gtacgccaac      900

atcgcaccaa ccaacgtgca cgtggcagga gagttcccta gcaaggagag gggaaggaag      960

cggcgctccg gaatcttccc tgtggcatgc agcgacggat acggcggcct ggtgaccacc     1020

gaccccaaga ccgccgaccc agtgtacggc aaggtgttca acccacccag gaacctgctg     1080

cccggcaggt tcaccaacct gctggacgtg gcagaggcat gtcccacctt cctgcacttc     1140

gacggcgacg tgccatacgt gaccaccaag accgactccg acagggtgct ggcacagttc     1200

gacctgtccc tggcagccaa gcacatgagc aacaccttcc tggccggcct ggcccagtac     1260

tacacccagt acagcggcac catcaacctg cacttcatgt tcaccggccc aaccgacgcc     1320

aaggccagat acatggtggc atacgcccct cccggaatgg agccacctaa gacccctgag     1380

gcagcagcac actgcatcca cgccgagtgg gacaccggcc tgaacagcaa gttcaccttc     1440

tccatcccct acctgagcgc cgcagactac gcatacaccg catccgacgt ggcagagaca     1500

accaacgtgc agggctgggt gtgcctgttc cagatcaccc acggcaaggc agacggcgac     1560

gcactggtgg tgctggccag cgccggcaag gacttcgacc tgagactgcc agtggacgca     1620

aggacccaga ggggaagaaa gaggagaagc accacctcca ccggagagtc cgccgaccca     1680

gtgaccgcca ccgtggagaa ctacggcggc gagacacagg tgcagcggcg ccagcacacc     1740

gacgtgagct tcatcctgga ccggttcgtg aaggtgaccc caaaggacca gatcaacgtg     1800

ctggacctga tgcagatccc tgcacacacc ctggtgggcg ccctgctgag gaccgccacc     1860

tactacttcg ccgacctgga ggtggccgtg aagcacgagg gcaacctgac ctgggtgcct     1920

aacggagcac cagaggccgc cctggacaac accaccaacc caaccgcata ccacaaggcc     1980

cctctgacca ggctggccct gccatacacc gcccctcaca gggtgctggc aaccgtgtac     2040

aacggcaact gcaagtacgg agagtcccct gtgaccaacg tgcgcggcga cctgcaggtg     2100

ctggcacaga aggcagcaag gaccctgccc accagcttca actacggcgc catcaaggcc     2160

accagggtga ccgagctgct gtacagaatg aagcgggccg agacatactg tcccagacca     2220

ctgctggcaa tccacccttc cgaggcaagg cacaagcaga agatcgtggc accagtgaag     2280

cagctgctga ggggacgcaa gaggcgctca accctgaact tcgacctcct caaactggct     2340

ggcgatgtgg aaagcaatcc tgga                                            2364


<210>  14
<211>  788
<212>  PRT
<213>  artificial sequence

<220>
<223>  Amino acid sequence of a synthetic consensus FMDV-O comprising 
       VP4, VP2, VP3, and VP1 operably linked to an IgE leader sequence

<400>  14

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Ala Gly Gln Ser Ser Pro Ala Thr Trp Ser Gln Asn Gln 
            20                  25                  30          


Ser Gly Asn Thr Gly Ser Ile Ile Asn Asn Tyr Tyr Met Gln Gln Tyr 
        35                  40                  45              


Gln Asn Ser Met Asp Thr Gln Leu Gly Asp Asn Ala Thr Ser Gly Gly 
    50                  55                  60                  


Ser Asn Glu Gly Ser Thr Asp Thr Thr Ser Thr His Thr Thr Asn Thr 
65                  70                  75                  80  


Gln Asn Asn Asp Trp Phe Ser Lys Leu Ala Ser Arg Gly Arg Lys Arg 
                85                  90                  95      


Arg Ser Asp Lys Lys Thr Glu Glu Thr Thr Leu Leu Glu Asp Arg Ile 
            100                 105                 110         


Leu Thr Thr Arg Asn Gly His Thr Thr Ser Thr Thr Gln Ser Ser Val 
        115                 120                 125             


Gly Val Thr Tyr Gly Tyr Ala Thr Ala Glu Asp Phe Val Ser Gly Pro 
    130                 135                 140                 


Asn Thr Ser Gly Leu Glu Thr Arg Val Val Gln Ala Glu Arg Phe Phe 
145                 150                 155                 160 


Lys Thr His Leu Phe Asp Trp Val Thr Ser Asp Pro Phe Gly Arg Cys 
                165                 170                 175     


Tyr Leu Leu Glu Leu Pro Thr Asp His Lys Gly Val Tyr Gly Ser Leu 
            180                 185                 190         


Thr Asp Ser Tyr Ala Tyr Met Arg Asn Gly Trp Asp Val Glu Val Thr 
        195                 200                 205             


Ala Val Gly Asn Gln Phe Asn Gly Gly Cys Leu Leu Val Ala Met Val 
    210                 215                 220                 


Pro Glu Leu Cys Ser Ile Asp Lys Arg Glu Leu Tyr Gln Leu Thr Leu 
225                 230                 235                 240 


Phe Pro His Gln Phe Ile Asn Pro Arg Thr Asn Met Thr Ala His Ile 
                245                 250                 255     


Thr Val Pro Phe Val Gly Val Asn Arg Tyr Asp Gln Tyr Lys Val His 
            260                 265                 270         


Lys Pro Trp Thr Leu Val Val Met Val Val Ala Pro Leu Thr Val Asn 
        275                 280                 285             


Thr Glu Gly Ala Pro Gln Ile Lys Val Tyr Ala Asn Ile Ala Pro Thr 
    290                 295                 300                 


Asn Val His Val Ala Gly Glu Phe Pro Ser Lys Glu Arg Gly Arg Lys 
305                 310                 315                 320 


Arg Arg Ser Gly Ile Phe Pro Val Ala Cys Ser Asp Gly Tyr Gly Gly 
                325                 330                 335     


Leu Val Thr Thr Asp Pro Lys Thr Ala Asp Pro Val Tyr Gly Lys Val 
            340                 345                 350         


Phe Asn Pro Pro Arg Asn Leu Leu Pro Gly Arg Phe Thr Asn Leu Leu 
        355                 360                 365             


Asp Val Ala Glu Ala Cys Pro Thr Phe Leu His Phe Asp Gly Asp Val 
    370                 375                 380                 


Pro Tyr Val Thr Thr Lys Thr Asp Ser Asp Arg Val Leu Ala Gln Phe 
385                 390                 395                 400 


Asp Leu Ser Leu Ala Ala Lys His Met Ser Asn Thr Phe Leu Ala Gly 
                405                 410                 415     


Leu Ala Gln Tyr Tyr Thr Gln Tyr Ser Gly Thr Ile Asn Leu His Phe 
            420                 425                 430         


Met Phe Thr Gly Pro Thr Asp Ala Lys Ala Arg Tyr Met Val Ala Tyr 
        435                 440                 445             


Ala Pro Pro Gly Met Glu Pro Pro Lys Thr Pro Glu Ala Ala Ala His 
    450                 455                 460                 


Cys Ile His Ala Glu Trp Asp Thr Gly Leu Asn Ser Lys Phe Thr Phe 
465                 470                 475                 480 


Ser Ile Pro Tyr Leu Ser Ala Ala Asp Tyr Ala Tyr Thr Ala Ser Asp 
                485                 490                 495     


Val Ala Glu Thr Thr Asn Val Gln Gly Trp Val Cys Leu Phe Gln Ile 
            500                 505                 510         


Thr His Gly Lys Ala Asp Gly Asp Ala Leu Val Val Leu Ala Ser Ala 
        515                 520                 525             


Gly Lys Asp Phe Asp Leu Arg Leu Pro Val Asp Ala Arg Thr Gln Arg 
    530                 535                 540                 


Gly Arg Lys Arg Arg Ser Thr Thr Ser Thr Gly Glu Ser Ala Asp Pro 
545                 550                 555                 560 


Val Thr Ala Thr Val Glu Asn Tyr Gly Gly Glu Thr Gln Val Gln Arg 
                565                 570                 575     


Arg Gln His Thr Asp Val Ser Phe Ile Leu Asp Arg Phe Val Lys Val 
            580                 585                 590         


Thr Pro Lys Asp Gln Ile Asn Val Leu Asp Leu Met Gln Ile Pro Ala 
        595                 600                 605             


His Thr Leu Val Gly Ala Leu Leu Arg Thr Ala Thr Tyr Tyr Phe Ala 
    610                 615                 620                 


Asp Leu Glu Val Ala Val Lys His Glu Gly Asn Leu Thr Trp Val Pro 
625                 630                 635                 640 


Asn Gly Ala Pro Glu Ala Ala Leu Asp Asn Thr Thr Asn Pro Thr Ala 
                645                 650                 655     


Tyr His Lys Ala Pro Leu Thr Arg Leu Ala Leu Pro Tyr Thr Ala Pro 
            660                 665                 670         


His Arg Val Leu Ala Thr Val Tyr Asn Gly Asn Cys Lys Tyr Gly Glu 
        675                 680                 685             


Ser Pro Val Thr Asn Val Arg Gly Asp Leu Gln Val Leu Ala Gln Lys 
    690                 695                 700                 


Ala Ala Arg Thr Leu Pro Thr Ser Phe Asn Tyr Gly Ala Ile Lys Ala 
705                 710                 715                 720 


Thr Arg Val Thr Glu Leu Leu Tyr Arg Met Lys Arg Ala Glu Thr Tyr 
                725                 730                 735     


Cys Pro Arg Pro Leu Leu Ala Ile His Pro Ser Glu Ala Arg His Lys 
            740                 745                 750         


Gln Lys Ile Val Ala Pro Val Lys Gln Leu Leu Arg Gly Arg Lys Arg 
        755                 760                 765             


Arg Ser Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
    770                 775                 780                 


Ser Asn Pro Gly 
785             


<210>  15
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  furin cleavage site

<400>  15

Arg Gly Arg Lys Arg Arg Ser 
1               5           


<210>  16
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgE leader sequence

<400>  16

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


