                         SEQUENCE LISTING

<110>  Bayer CropScience LP
 
<120>  AXMI669 AND AXMI991 TOXIN GENES AND METHODS FOR THEIR USE

<130>  APA16-6008 WO

<150>  62/425,669
<151>  2016-11-23

<150>  62/425,729
<151>  2016-11-23

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  3510
<212>  DNA
<213>  Bacillus thuringiensis

<400>  1
atgggaggaa aaagtatgaa tcgaaataat caaggtgaat atgaaattat tgacacttcc       60

acttgtgggt gcccgtcaga tgatgttgta aaataccctt tggcaagtga tccaaatgcc      120

tcgttacaaa atatgaacta taaagaatat ttacaaatgg cagagggaga ctatataaat      180

tcgtatataa atcctggaaa tgttagaacc ggagtacaaa ctggaattga tattgttgcg      240

ctactagtag gaactttagg gggtgcaatt ggtggtatag caactggttt gctttccact      300

ctttttggtt ttctctggcc atctaatgat caagaggtat gggaagcttt tatagcacaa      360

atggaagaac tgattgaaca aaggatagca gatcaagtag taaggtctgc acttgatgac      420

ttaactggaa ttcaaaatta ttataatcaa tatctaatag cattaaagga atgggaggaa      480

agaccaaacg gcgtaagagc aaacctagtt ttgcaaagat ttgaaatctt gcacgcgcta      540

tttgtaagta gtatgccaag ttttggtagt ggtcctggaa gtcgaagatt tgagtcacaa      600

ttgctgacag tttatgcaca agcggcaaat ctgcatttgt tattattaag agatgctgac      660

atttatggag caagatgggg acttcaacaa ggtcagatta acctatattt taatgagcta      720

caaactcgta ctcgagatta tactaatcat tgtgtaactg cgtacaataa tgggttagag      780

gagatacgag gaacaagcgc tgaaagttgg ttgaggtacc atcaattccg tagagaggcg      840

acactaatag caatggattt agtggcgata ttcccatatt acaacgtacg agaatatcca      900

attggggtaa atcctcagct tacacgtgat gtatatacag atccaattgg ggttactttc      960

agaagagaag attgggcaac aggagtagaa tgcagaccat gggtaaatac tccttacatg     1020

agcttttcgg atcttgaaaa tgcaataatt cgtccaccac atctatttga aacattacgt     1080

aatttaacaa ttcatacagg tcgatataac ctagtaggag gggcgagatt tattgaagga     1140

tgggtcggac attctgtaac aaatactcgc ttgggtaatt caacagtatt tacaagtaat     1200

tatggttctt tgccacctcg ttttcaagtt tttaatttta ctaattttga tgtttaccaa     1260

attaatacga gagcagattc tacaggtacc tttagaatcc ctggatttgc agttacaagg     1320

gcccaattca ttccgggtgg gacttattca gtagctcacc gagatccagg ggcatgtcaa     1380

caagattatg attcaattga agagttacca agtctagacc cggatgaacc tattaataga     1440

agttatagtc atagattatc gcatgttacc ctttataaat atactctctc agatacagat     1500

tatggagtta tcaattatac agattatgga agtatgcctg catatgtctg gacacatcgc     1560

gatgtggacc ttactaacac gattactgca gatagaatta ctcaaatacc agtggtaaag     1620

gcatatgagc taagtggtgc tactgtcgtg aaaggtccag gattcacagg aggagatgta     1680

atccgaagaa caaatactgg tggatttgga gcaataaggg tgtcggtcac tggaccgcta     1740

acacaacgat atcgcataag gttccgttat gcttcgacaa tagattttga tttctttgta     1800

acacgtggag gaactactat aaataatttt agatttacac gtacaatgaa taggggacag     1860

gaatcaagat atgaatccta tcgtactgta gagtttacaa ctccttttaa ctttacacaa     1920

agtcaagata taattcgaac atctatccag ggacttagtg gaaatgggga agtatacctt     1980

gatagaattg aaatcatccc tgtaaatcca acacgagaag cggaagagga tttagaagcg     2040

gcgaagaaag cggtggcgag cttgtttaca cgcacaaggg acgggttaca agtaaatgtg     2100

acagattatc aagtcgatca agcggcaaat ttagtgtcat gcttatcaga tgaacaatat     2160

gggcatgaca aaaagatgtt attggaagcc gtacgcgcag caaaacgcct cagccgcgaa     2220

cgcaacttac ttcaagatcc agattttaat acaatcaata gtacagaaga aaatggctgg     2280

aaggcaagta acggtgttac tattagcgag ggtggtccat tctttaaagg tcgtgcactt     2340

cagctagcaa gcgcaagaga aaattatcca acatacatct atcaaaaagt agatgcatcg     2400

gagttaaagc cgtatacacg ttatagactg gatgggttcg tgaagagtag tcaagattta     2460

gaaattgatc tcattcacca tcataaagtc catcttgtga aaaatgtacc agataattta     2520

gtatctgata cttactcgga tgattcttgt agtggaatca atcgatgtca ggaacaacag     2580

atggtaaatg cgcaactgga aacagaacat catcatccga tggattgctg tgaagcagct     2640

caaacacatg agttttcttc ctatattgat acaggggatt tgaattcgag tgtagaccag     2700

ggaatctggg tgatctttaa agttcgaaca accgatggtt atgcgacgtt aggaaatctt     2760

gaattggtag agatcggacc gttatcgggt gaatctctag aacgtgaaca aagggataat     2820

gcaaaatgga gtgcagagct aggaagaaag cgtgcagaaa cagatcgcgt gtatcaagat     2880

gccaaacaat ccatcaatca tttatttgtg gattatcaag atcaacaatt aaatccagaa     2940

atagggatgg cagatattat ggacgctcaa aatcttgtcg catcaatttc agatgtatat     3000

agcgatgcag tactgcaaat ccctggaatt aactatgaga tttacacaga gctatccaat     3060

cgcttacaac aagcatcgta tctgtatacg tctcgaaatg cggtgcaaaa tggggacttt     3120

aacagcggtc tagatagttg gaatgcaaca gggggggcta cggtacaaca ggatggcaat     3180

acgcaattct tagttctttc tcattgggat gcacaagttt ctcaacaatt tagagtacag     3240

ccgaattgta aatatgtatt acgtgtaaca gcagagaaag taggcggcgg agacggatac     3300

gtcacaatcc gagatggcgc tcatcaccaa gaaactctta catttaatgc atgtgactac     3360

gatgtaaatg gtacgtatgt caatgacaat tcgtacataa caaaagaagt ggtattctat     3420

tcacatacag aacacatgtg ggtagaggta aatgaaacag aaggtgcatt tcatatagat     3480

agtattgaat tcgttgaaac agaaaagtaa                                      3510


<210>  2
<211>  1164
<212>  PRT
<213>  Bacillus thuringiensis

<400>  2

Met Asn Arg Asn Asn Gln Gly Glu Tyr Glu Ile Ile Asp Thr Ser Thr 
1               5                   10                  15      


Cys Gly Cys Pro Ser Asp Asp Val Val Lys Tyr Pro Leu Ala Ser Asp 
            20                  25                  30          


Pro Asn Ala Ser Leu Gln Asn Met Asn Tyr Lys Glu Tyr Leu Gln Met 
        35                  40                  45              


Ala Glu Gly Asp Tyr Ile Asn Ser Tyr Ile Asn Pro Gly Asn Val Arg 
    50                  55                  60                  


Thr Gly Val Gln Thr Gly Ile Asp Ile Val Ala Leu Leu Val Gly Thr 
65                  70                  75                  80  


Leu Gly Gly Ala Ile Gly Gly Ile Ala Thr Gly Leu Leu Ser Thr Leu 
                85                  90                  95      


Phe Gly Phe Leu Trp Pro Ser Asn Asp Gln Glu Val Trp Glu Ala Phe 
            100                 105                 110         


Ile Ala Gln Met Glu Glu Leu Ile Glu Gln Arg Ile Ala Asp Gln Val 
        115                 120                 125             


Val Arg Ser Ala Leu Asp Asp Leu Thr Gly Ile Gln Asn Tyr Tyr Asn 
    130                 135                 140                 


Gln Tyr Leu Ile Ala Leu Lys Glu Trp Glu Glu Arg Pro Asn Gly Val 
145                 150                 155                 160 


Arg Ala Asn Leu Val Leu Gln Arg Phe Glu Ile Leu His Ala Leu Phe 
                165                 170                 175     


Val Ser Ser Met Pro Ser Phe Gly Ser Gly Pro Gly Ser Arg Arg Phe 
            180                 185                 190         


Glu Ser Gln Leu Leu Thr Val Tyr Ala Gln Ala Ala Asn Leu His Leu 
        195                 200                 205             


Leu Leu Leu Arg Asp Ala Asp Ile Tyr Gly Ala Arg Trp Gly Leu Gln 
    210                 215                 220                 


Gln Gly Gln Ile Asn Leu Tyr Phe Asn Glu Leu Gln Thr Arg Thr Arg 
225                 230                 235                 240 


Asp Tyr Thr Asn His Cys Val Thr Ala Tyr Asn Asn Gly Leu Glu Glu 
                245                 250                 255     


Ile Arg Gly Thr Ser Ala Glu Ser Trp Leu Arg Tyr His Gln Phe Arg 
            260                 265                 270         


Arg Glu Ala Thr Leu Ile Ala Met Asp Leu Val Ala Ile Phe Pro Tyr 
        275                 280                 285             


Tyr Asn Val Arg Glu Tyr Pro Ile Gly Val Asn Pro Gln Leu Thr Arg 
    290                 295                 300                 


Asp Val Tyr Thr Asp Pro Ile Gly Val Thr Phe Arg Arg Glu Asp Trp 
305                 310                 315                 320 


Ala Thr Gly Val Glu Cys Arg Pro Trp Val Asn Thr Pro Tyr Met Ser 
                325                 330                 335     


Phe Ser Asp Leu Glu Asn Ala Ile Ile Arg Pro Pro His Leu Phe Glu 
            340                 345                 350         


Thr Leu Arg Asn Leu Thr Ile His Thr Gly Arg Tyr Asn Leu Val Gly 
        355                 360                 365             


Gly Ala Arg Phe Ile Glu Gly Trp Val Gly His Ser Val Thr Asn Thr 
    370                 375                 380                 


Arg Leu Gly Asn Ser Thr Val Phe Thr Ser Asn Tyr Gly Ser Leu Pro 
385                 390                 395                 400 


Pro Arg Phe Gln Val Phe Asn Phe Thr Asn Phe Asp Val Tyr Gln Ile 
                405                 410                 415     


Asn Thr Arg Ala Asp Ser Thr Gly Thr Phe Arg Ile Pro Gly Phe Ala 
            420                 425                 430         


Val Thr Arg Ala Gln Phe Ile Pro Gly Gly Thr Tyr Ser Val Ala His 
        435                 440                 445             


Arg Asp Pro Gly Ala Cys Gln Gln Asp Tyr Asp Ser Ile Glu Glu Leu 
    450                 455                 460                 


Pro Ser Leu Asp Pro Asp Glu Pro Ile Asn Arg Ser Tyr Ser His Arg 
465                 470                 475                 480 


Leu Ser His Val Thr Leu Tyr Lys Tyr Thr Leu Ser Asp Thr Asp Tyr 
                485                 490                 495     


Gly Val Ile Asn Tyr Thr Asp Tyr Gly Ser Met Pro Ala Tyr Val Trp 
            500                 505                 510         


Thr His Arg Asp Val Asp Leu Thr Asn Thr Ile Thr Ala Asp Arg Ile 
        515                 520                 525             


Thr Gln Ile Pro Val Val Lys Ala Tyr Glu Leu Ser Gly Ala Thr Val 
    530                 535                 540                 


Val Lys Gly Pro Gly Phe Thr Gly Gly Asp Val Ile Arg Arg Thr Asn 
545                 550                 555                 560 


Thr Gly Gly Phe Gly Ala Ile Arg Val Ser Val Thr Gly Pro Leu Thr 
                565                 570                 575     


Gln Arg Tyr Arg Ile Arg Phe Arg Tyr Ala Ser Thr Ile Asp Phe Asp 
            580                 585                 590         


Phe Phe Val Thr Arg Gly Gly Thr Thr Ile Asn Asn Phe Arg Phe Thr 
        595                 600                 605             


Arg Thr Met Asn Arg Gly Gln Glu Ser Arg Tyr Glu Ser Tyr Arg Thr 
    610                 615                 620                 


Val Glu Phe Thr Thr Pro Phe Asn Phe Thr Gln Ser Gln Asp Ile Ile 
625                 630                 635                 640 


Arg Thr Ser Ile Gln Gly Leu Ser Gly Asn Gly Glu Val Tyr Leu Asp 
                645                 650                 655     


Arg Ile Glu Ile Ile Pro Val Asn Pro Thr Arg Glu Ala Glu Glu Asp 
            660                 665                 670         


Leu Glu Ala Ala Lys Lys Ala Val Ala Ser Leu Phe Thr Arg Thr Arg 
        675                 680                 685             


Asp Gly Leu Gln Val Asn Val Thr Asp Tyr Gln Val Asp Gln Ala Ala 
    690                 695                 700                 


Asn Leu Val Ser Cys Leu Ser Asp Glu Gln Tyr Gly His Asp Lys Lys 
705                 710                 715                 720 


Met Leu Leu Glu Ala Val Arg Ala Ala Lys Arg Leu Ser Arg Glu Arg 
                725                 730                 735     


Asn Leu Leu Gln Asp Pro Asp Phe Asn Thr Ile Asn Ser Thr Glu Glu 
            740                 745                 750         


Asn Gly Trp Lys Ala Ser Asn Gly Val Thr Ile Ser Glu Gly Gly Pro 
        755                 760                 765             


Phe Phe Lys Gly Arg Ala Leu Gln Leu Ala Ser Ala Arg Glu Asn Tyr 
    770                 775                 780                 


Pro Thr Tyr Ile Tyr Gln Lys Val Asp Ala Ser Glu Leu Lys Pro Tyr 
785                 790                 795                 800 


Thr Arg Tyr Arg Leu Asp Gly Phe Val Lys Ser Ser Gln Asp Leu Glu 
                805                 810                 815     


Ile Asp Leu Ile His His His Lys Val His Leu Val Lys Asn Val Pro 
            820                 825                 830         


Asp Asn Leu Val Ser Asp Thr Tyr Ser Asp Asp Ser Cys Ser Gly Ile 
        835                 840                 845             


Asn Arg Cys Gln Glu Gln Gln Met Val Asn Ala Gln Leu Glu Thr Glu 
    850                 855                 860                 


His His His Pro Met Asp Cys Cys Glu Ala Ala Gln Thr His Glu Phe 
865                 870                 875                 880 


Ser Ser Tyr Ile Asp Thr Gly Asp Leu Asn Ser Ser Val Asp Gln Gly 
                885                 890                 895     


Ile Trp Val Ile Phe Lys Val Arg Thr Thr Asp Gly Tyr Ala Thr Leu 
            900                 905                 910         


Gly Asn Leu Glu Leu Val Glu Ile Gly Pro Leu Ser Gly Glu Ser Leu 
        915                 920                 925             


Glu Arg Glu Gln Arg Asp Asn Ala Lys Trp Ser Ala Glu Leu Gly Arg 
    930                 935                 940                 


Lys Arg Ala Glu Thr Asp Arg Val Tyr Gln Asp Ala Lys Gln Ser Ile 
945                 950                 955                 960 


Asn His Leu Phe Val Asp Tyr Gln Asp Gln Gln Leu Asn Pro Glu Ile 
                965                 970                 975     


Gly Met Ala Asp Ile Met Asp Ala Gln Asn Leu Val Ala Ser Ile Ser 
            980                 985                 990         


Asp Val Tyr Ser Asp Ala Val Leu  Gln Ile Pro Gly Ile  Asn Tyr Glu 
        995                 1000                 1005             


Ile Tyr  Thr Glu Leu Ser Asn  Arg Leu Gln Gln Ala  Ser Tyr Leu 
    1010                 1015                 1020             


Tyr Thr  Ser Arg Asn Ala Val  Gln Asn Gly Asp Phe  Asn Ser Gly 
    1025                 1030                 1035             


Leu Asp  Ser Trp Asn Ala Thr  Gly Gly Ala Thr Val  Gln Gln Asp 
    1040                 1045                 1050             


Gly Asn  Thr Gln Phe Leu Val  Leu Ser His Trp Asp  Ala Gln Val 
    1055                 1060                 1065             


Ser Gln  Gln Phe Arg Val Gln  Pro Asn Cys Lys Tyr  Val Leu Arg 
    1070                 1075                 1080             


Val Thr  Ala Glu Lys Val Gly  Gly Gly Asp Gly Tyr  Val Thr Ile 
    1085                 1090                 1095             


Arg Asp  Gly Ala His His Gln  Glu Thr Leu Thr Phe  Asn Ala Cys 
    1100                 1105                 1110             


Asp Tyr  Asp Val Asn Gly Thr  Tyr Val Asn Asp Asn  Ser Tyr Ile 
    1115                 1120                 1125             


Thr Lys  Glu Val Val Phe Tyr  Ser His Thr Glu His  Met Trp Val 
    1130                 1135                 1140             


Glu Val  Asn Glu Thr Glu Gly  Ala Phe His Ile Asp  Ser Ile Glu 
    1145                 1150                 1155             


Phe Val  Glu Thr Glu Lys 
    1160                 


<210>  3
<211>  3471
<212>  DNA
<213>  Bacillus thuringiensis

<400>  3
atgaatcgaa ataatccaaa tgaatatgaa attattgatg ccccctattg tgggtgtccg       60

tcagatgatg atgtgaggta tcctttggca agtgacccaa atgcagcgtt ccaaaatatg      120

aactataaag agtatttaca aacgtatgat ggagactaca caggttctct tatcaatcct      180

aacttatcta ttaatcctag agatgtacta caaacaggta ttaatattgt gggaagaata      240

ctagggtttt taggtgttcc atttgcgggt caactagtta ctttctatac ctttctctta      300

aatcagttgt ggccaactaa tgataatgca gtatgggaag cttttatggc gcaaatagaa      360

gagctaatcg atcaaaaaat atcggcgcaa gtagtaagga atgcactcga tgacttaact      420

ggattacacg attattatga ggagtattta gcagcattag aggagtggct ggaaagaccg      480

aacggagcaa gagctaactt agttacacag aggtttgaaa acctgcatac tgcatttgta      540

actagaatgc caagctttgg tacgggtcct ggtagtcaaa gagatgcggt agcgttgttg      600

acggtatatg cacaagcagc gaatttgcat ttgttattat taaaagatgc tgaaatttat      660

ggggcaagat ggggacttca acaagggcaa attaacttat attttaatgc tcaacaagaa      720

cgtactcgaa tttataccaa tcattgtgtg gaaacatata atagaggatt agaagatgta      780

agaggaacaa atacagaaag ttggttaaat taccatcgat tccgtagaga gatgacatta      840

atggcaatgg atttagtggc cctattccca ttctataatg tgcgacaata tccaaatggg      900

gcaaatccac agcttacacg tgaaatatat acagatccaa tcgtatataa tccaccagct      960

aatcagggaa tttgccgacg ttgggggaat aatccgtata atacattttc tgaacttgaa     1020

aatgctttta ttcgcccgcc acatcttttt gataggttga acagattaac tatttctaga     1080

aaccgatata cagctccaac aactaatagc ttcctagact attggtcagg tcatacttta     1140

caaagccagt atgcaaatag cccgacgata tatgaaacta gttacggtca gattacctcg     1200

aacacacatc ccttcaatac gactaatgga gccaatgcaa tacagtcaag agcaagaaat     1260

tttggtaact tatacgctaa tttgtatggc gttagctttt taaatatttc ccgagcaggt     1320

gtgatgggtg aaatcaccaa tgcagctaat acgtgtttgc aagaccttac tacaactgaa     1380

gaactaccac tagagaataa taattttaat tttttatctc atgttacttt cttacgcttc     1440

aatactactc agggtggccc ctttgcaaca ttagggtttg tacccacata tgtgtggaca     1500

cgtgaagatg tagattttac gaacacaatt actgcggata gaattactca attaccatta     1560

gtaaagtcat ccgcacctgt tgctggtact acggtcttaa aaggaccagg atttacggga     1620

ggggatatac tccgaagaac aacgaatggc acatttggaa cgttaagagt aacggttaat     1680

tcaccgttaa cacaacaata tcgcctaaga gttcgttttg cctcaacagg aaatttcagt     1740

ataagggtac tacgtggagg gacttctatc ggtgatgtta gacttgggag cacaatgaac     1800

agagggcagg aactaactta cgaatctttt gtcacaagag agtttactac tggtccgttc     1860

aatccgcctt ttacatttac acaagctcaa gagattctaa cagtgaatgc agaaggtgtt     1920

agcaccggtg gggaatatta tatagataaa attgaaatta tccctgtgaa tccagcacgt     1980

gaggcggaag aggatctaga ggcagcgaag aaagcggtgg cgagcttgtt tacacgcaca     2040

agagatggat tacaggtgaa tgtgacagat tatcaagtcg atcgagcggc aaatttagtg     2100

tcatgcttat cagatgaaca atatgggcat gacaaaaaga tgttactaga agcggtacgc     2160

gcggcaaaac gcctcagccg cgaacgcaac ttacttcaag atccagattt taatgaaata     2220

aatagcacag aagaaaatgg ctggaaggca agtaacggtg ttactattag cgagggcggt     2280

ccattcttta aaggtcgtgc acttcagtta gcaagcgcac gtgaaaatta cccaacatac     2340

atctatcaaa aggtagatgc atcgacgtta aaaccttata cacgatataa actagatgga     2400

tttgtgcaaa gtagtcaaga tttagaaatt gacctcattc atcatcataa agtccacctc     2460

gtgaaaaatg taccagataa tttagtatct gatacttatt ctgatggctc atgtagtgga     2520

attaaccgtt gtgaggaaca acatcaggta gatgtgcagc tagatgcgga ggatcatcca     2580

aaggattgtt gtgaagcggc tcaaacacat gagttttctt cctatattca tacaggtgat     2640

ctaaatgcaa gtgtagatca aggcatttgg gttgtattgc aggttcgaac aacagatggt     2700

tatgcgacgt taggaaatct tgaattggta gaggttggtc cattatcggg tgaatcttta     2760

gaacgagaac aaagagataa tgcgaaatgg aatgaagagg taggaagaaa gcgtgcagaa     2820

acagatcgca tatatcaaga tgcgaaacaa gcaattaacc atctatttgt agactatcaa     2880

gatcaacaat taagtccaga ggtagggatg gcggatatta ttgatgctca aaatcttatc     2940

gcatcaattt cagatgtata tagcgatgca gtactgcaaa tccctgggat taactacgag     3000

atgtatacag agttatccaa tcgattacaa caagcatcgt atctgtatac gtctcgaaat     3060

gtcgtgcaaa atggggactt taacagtggt ttagatagtt ggaatgcaac aactgataca     3120

gctgttcagc aggatggcaa tatgcatttc ttagttcttt cccattggga tgcacaagtt     3180

tctcaacaat ttagagtaca gccgaattgt aaatatgtgt tacgtgtgac agcgaagaaa     3240

gtagggaacg gagatggata tgttactatc caagatggcg ctcatcaccg agaaacactg     3300

acattcaatg catgtgacta cgatgtaaat ggtacgcatg taaatgacaa ttcgtatatt     3360

acaaaagaat tggtgttcta tccaaagacg gaacatatgt gggtagaggt aagtgaaaca     3420

gaaggtacct tctatataga cagcattgag ttcattgaaa cacaagagta g              3471


<210>  4
<211>  1156
<212>  PRT
<213>  Bacillus thuringiensis

<400>  4

Met Asn Arg Asn Asn Pro Asn Glu Tyr Glu Ile Ile Asp Ala Pro Tyr 
1               5                   10                  15      


Cys Gly Cys Pro Ser Asp Asp Asp Val Arg Tyr Pro Leu Ala Ser Asp 
            20                  25                  30          


Pro Asn Ala Ala Phe Gln Asn Met Asn Tyr Lys Glu Tyr Leu Gln Thr 
        35                  40                  45              


Tyr Asp Gly Asp Tyr Thr Gly Ser Leu Ile Asn Pro Asn Leu Ser Ile 
    50                  55                  60                  


Asn Pro Arg Asp Val Leu Gln Thr Gly Ile Asn Ile Val Gly Arg Ile 
65                  70                  75                  80  


Leu Gly Phe Leu Gly Val Pro Phe Ala Gly Gln Leu Val Thr Phe Tyr 
                85                  90                  95      


Thr Phe Leu Leu Asn Gln Leu Trp Pro Thr Asn Asp Asn Ala Val Trp 
            100                 105                 110         


Glu Ala Phe Met Ala Gln Ile Glu Glu Leu Ile Asp Gln Lys Ile Ser 
        115                 120                 125             


Ala Gln Val Val Arg Asn Ala Leu Asp Asp Leu Thr Gly Leu His Asp 
    130                 135                 140                 


Tyr Tyr Glu Glu Tyr Leu Ala Ala Leu Glu Glu Trp Leu Glu Arg Pro 
145                 150                 155                 160 


Asn Gly Ala Arg Ala Asn Leu Val Thr Gln Arg Phe Glu Asn Leu His 
                165                 170                 175     


Thr Ala Phe Val Thr Arg Met Pro Ser Phe Gly Thr Gly Pro Gly Ser 
            180                 185                 190         


Gln Arg Asp Ala Val Ala Leu Leu Thr Val Tyr Ala Gln Ala Ala Asn 
        195                 200                 205             


Leu His Leu Leu Leu Leu Lys Asp Ala Glu Ile Tyr Gly Ala Arg Trp 
    210                 215                 220                 


Gly Leu Gln Gln Gly Gln Ile Asn Leu Tyr Phe Asn Ala Gln Gln Glu 
225                 230                 235                 240 


Arg Thr Arg Ile Tyr Thr Asn His Cys Val Glu Thr Tyr Asn Arg Gly 
                245                 250                 255     


Leu Glu Asp Val Arg Gly Thr Asn Thr Glu Ser Trp Leu Asn Tyr His 
            260                 265                 270         


Arg Phe Arg Arg Glu Met Thr Leu Met Ala Met Asp Leu Val Ala Leu 
        275                 280                 285             


Phe Pro Phe Tyr Asn Val Arg Gln Tyr Pro Asn Gly Ala Asn Pro Gln 
    290                 295                 300                 


Leu Thr Arg Glu Ile Tyr Thr Asp Pro Ile Val Tyr Asn Pro Pro Ala 
305                 310                 315                 320 


Asn Gln Gly Ile Cys Arg Arg Trp Gly Asn Asn Pro Tyr Asn Thr Phe 
                325                 330                 335     


Ser Glu Leu Glu Asn Ala Phe Ile Arg Pro Pro His Leu Phe Asp Arg 
            340                 345                 350         


Leu Asn Arg Leu Thr Ile Ser Arg Asn Arg Tyr Thr Ala Pro Thr Thr 
        355                 360                 365             


Asn Ser Phe Leu Asp Tyr Trp Ser Gly His Thr Leu Gln Ser Gln Tyr 
    370                 375                 380                 


Ala Asn Ser Pro Thr Ile Tyr Glu Thr Ser Tyr Gly Gln Ile Thr Ser 
385                 390                 395                 400 


Asn Thr His Pro Phe Asn Thr Thr Asn Gly Ala Asn Ala Ile Gln Ser 
                405                 410                 415     


Arg Ala Arg Asn Phe Gly Asn Leu Tyr Ala Asn Leu Tyr Gly Val Ser 
            420                 425                 430         


Phe Leu Asn Ile Ser Arg Ala Gly Val Met Gly Glu Ile Thr Asn Ala 
        435                 440                 445             


Ala Asn Thr Cys Leu Gln Asp Leu Thr Thr Thr Glu Glu Leu Pro Leu 
    450                 455                 460                 


Glu Asn Asn Asn Phe Asn Phe Leu Ser His Val Thr Phe Leu Arg Phe 
465                 470                 475                 480 


Asn Thr Thr Gln Gly Gly Pro Phe Ala Thr Leu Gly Phe Val Pro Thr 
                485                 490                 495     


Tyr Val Trp Thr Arg Glu Asp Val Asp Phe Thr Asn Thr Ile Thr Ala 
            500                 505                 510         


Asp Arg Ile Thr Gln Leu Pro Leu Val Lys Ser Ser Ala Pro Val Ala 
        515                 520                 525             


Gly Thr Thr Val Leu Lys Gly Pro Gly Phe Thr Gly Gly Asp Ile Leu 
    530                 535                 540                 


Arg Arg Thr Thr Asn Gly Thr Phe Gly Thr Leu Arg Val Thr Val Asn 
545                 550                 555                 560 


Ser Pro Leu Thr Gln Gln Tyr Arg Leu Arg Val Arg Phe Ala Ser Thr 
                565                 570                 575     


Gly Asn Phe Ser Ile Arg Val Leu Arg Gly Gly Thr Ser Ile Gly Asp 
            580                 585                 590         


Val Arg Leu Gly Ser Thr Met Asn Arg Gly Gln Glu Leu Thr Tyr Glu 
        595                 600                 605             


Ser Phe Val Thr Arg Glu Phe Thr Thr Gly Pro Phe Asn Pro Pro Phe 
    610                 615                 620                 


Thr Phe Thr Gln Ala Gln Glu Ile Leu Thr Val Asn Ala Glu Gly Val 
625                 630                 635                 640 


Ser Thr Gly Gly Glu Tyr Tyr Ile Asp Lys Ile Glu Ile Ile Pro Val 
                645                 650                 655     


Asn Pro Ala Arg Glu Ala Glu Glu Asp Leu Glu Ala Ala Lys Lys Ala 
            660                 665                 670         


Val Ala Ser Leu Phe Thr Arg Thr Arg Asp Gly Leu Gln Val Asn Val 
        675                 680                 685             


Thr Asp Tyr Gln Val Asp Arg Ala Ala Asn Leu Val Ser Cys Leu Ser 
    690                 695                 700                 


Asp Glu Gln Tyr Gly His Asp Lys Lys Met Leu Leu Glu Ala Val Arg 
705                 710                 715                 720 


Ala Ala Lys Arg Leu Ser Arg Glu Arg Asn Leu Leu Gln Asp Pro Asp 
                725                 730                 735     


Phe Asn Glu Ile Asn Ser Thr Glu Glu Asn Gly Trp Lys Ala Ser Asn 
            740                 745                 750         


Gly Val Thr Ile Ser Glu Gly Gly Pro Phe Phe Lys Gly Arg Ala Leu 
        755                 760                 765             


Gln Leu Ala Ser Ala Arg Glu Asn Tyr Pro Thr Tyr Ile Tyr Gln Lys 
    770                 775                 780                 


Val Asp Ala Ser Thr Leu Lys Pro Tyr Thr Arg Tyr Lys Leu Asp Gly 
785                 790                 795                 800 


Phe Val Gln Ser Ser Gln Asp Leu Glu Ile Asp Leu Ile His His His 
                805                 810                 815     


Lys Val His Leu Val Lys Asn Val Pro Asp Asn Leu Val Ser Asp Thr 
            820                 825                 830         


Tyr Ser Asp Gly Ser Cys Ser Gly Ile Asn Arg Cys Glu Glu Gln His 
        835                 840                 845             


Gln Val Asp Val Gln Leu Asp Ala Glu Asp His Pro Lys Asp Cys Cys 
    850                 855                 860                 


Glu Ala Ala Gln Thr His Glu Phe Ser Ser Tyr Ile His Thr Gly Asp 
865                 870                 875                 880 


Leu Asn Ala Ser Val Asp Gln Gly Ile Trp Val Val Leu Gln Val Arg 
                885                 890                 895     


Thr Thr Asp Gly Tyr Ala Thr Leu Gly Asn Leu Glu Leu Val Glu Val 
            900                 905                 910         


Gly Pro Leu Ser Gly Glu Ser Leu Glu Arg Glu Gln Arg Asp Asn Ala 
        915                 920                 925             


Lys Trp Asn Glu Glu Val Gly Arg Lys Arg Ala Glu Thr Asp Arg Ile 
    930                 935                 940                 


Tyr Gln Asp Ala Lys Gln Ala Ile Asn His Leu Phe Val Asp Tyr Gln 
945                 950                 955                 960 


Asp Gln Gln Leu Ser Pro Glu Val Gly Met Ala Asp Ile Ile Asp Ala 
                965                 970                 975     


Gln Asn Leu Ile Ala Ser Ile Ser Asp Val Tyr Ser Asp Ala Val Leu 
            980                 985                 990         


Gln Ile Pro Gly Ile Asn Tyr Glu  Met Tyr Thr Glu Leu  Ser Asn Arg 
        995                 1000                 1005             


Leu Gln  Gln Ala Ser Tyr Leu  Tyr Thr Ser Arg Asn  Val Val Gln 
    1010                 1015                 1020             


Asn Gly  Asp Phe Asn Ser Gly  Leu Asp Ser Trp Asn  Ala Thr Thr 
    1025                 1030                 1035             


Asp Thr  Ala Val Gln Gln Asp  Gly Asn Met His Phe  Leu Val Leu 
    1040                 1045                 1050             


Ser His  Trp Asp Ala Gln Val  Ser Gln Gln Phe Arg  Val Gln Pro 
    1055                 1060                 1065             


Asn Cys  Lys Tyr Val Leu Arg  Val Thr Ala Lys Lys  Val Gly Asn 
    1070                 1075                 1080             


Gly Asp  Gly Tyr Val Thr Ile  Gln Asp Gly Ala His  His Arg Glu 
    1085                 1090                 1095             


Thr Leu  Thr Phe Asn Ala Cys  Asp Tyr Asp Val Asn  Gly Thr His 
    1100                 1105                 1110             


Val Asn  Asp Asn Ser Tyr Ile  Thr Lys Glu Leu Val  Phe Tyr Pro 
    1115                 1120                 1125             


Lys Thr  Glu His Met Trp Val  Glu Val Ser Glu Thr  Glu Gly Thr 
    1130                 1135                 1140             


Phe Tyr  Ile Asp Ser Ile Glu  Phe Ile Glu Thr Gln  Glu 
    1145                 1150                 1155     


<210>  5
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER targeting peptide

<400>  5

Lys Asp Glu Leu 
1               


