                         SEQUENCE LISTING

<110>  aratinga.bio AIO
 
<120>  Viral Vector Constructs for Expression of Genetic Adjuvants 
       Activating the CD40 and STING Pathways

<130>  21062-5

<140>  PCT/IB2017/001553
<141>  2017-11-28

<150>  US 62/426,860
<151>  2016-11-28

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  1158
<212>  DNA
<213>  Epstein Barr virus

<400>  1
atggatctgg acctggaaag aggacctcct ggacctagac ggcctcctag aggaccacct       60

ctgagcagct ctattggact ggccctgctg ctgcttctgc tggctctgct gttctggctg      120

tacatcatca tgagcaactg gaccggcgga gcactgctgg tgctgtatgc ctttgctctg      180

atgctggtca tcatcatcct gatcatcttc atcttccggc gggacctgct gtgtcctctg      240

ggagcacttt gtctgttgct gctgatgatc accctcctgc tgatcgccct gtggaacctg      300

catggacagg ccctgtatct gggaatcgtg ctgttcatct tcggctgcct gctggttctc      360

ggcctgtgga tctacctgct ggaaatcctt tggagactgg gcgccaccat ctggcagctg      420

ctggcctttt tcctggcctt ctttctggat atcatcctcc tcatcattgc cctgtacctg      480

cagcagaact ggtggaccct gctggtggat ctgctttggc tgctgctctt tctggccatc      540

ctgatttgga tgtactacca cggccagcgg cacagcgacg aacaccacca tgatgacagc      600

ctgcctcatc ctcagcaggc caccgacgat agcagcaacc agagcgacag caacagcaac      660

gagggcagac atctgctgct ggtgtctggt gctggcgacg gacctcctct gtgttctcaa      720

aatcttggcg cccctggcgg cggaccaaac aatggacctc aggaccccga caacaccgac      780

gacaatggcc ctcaagatcc tgataatacc gatgacaacg gcccacacga ccctctgcct      840

caagacccag ataacacaga cgataacggt ccacaagatc cggacaatac tgacgataat      900

ggaccccacg atccactgcc tcacaaccct agcgatagcg ccggaaatga tggcggacct      960

ccacagctga ccgaggaagt ggaaaacaaa ggcggagatc agggccctcc tctgatgacc     1020

gatggcggag gtggacactc tcacgattct ggccacgacg gcatcgaccc tcatctgcct     1080

acactgctgc tcggcacatc tggctctggc ggcgacgatg atgatcctca tggacctgtg     1140

cagctgagct actacgac                                                   1158


<210>  2
<211>  386
<212>  PRT
<213>  Epstein Barr virus

<400>  2

Met Asp Leu Asp Leu Glu Arg Gly Pro Pro Gly Pro Arg Arg Pro Pro 
1               5                   10                  15      


Arg Gly Pro Pro Leu Ser Ser Ser Ile Gly Leu Ala Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Ala Leu Leu Phe Trp Leu Tyr Ile Ile Met Ser Asn Trp Thr 
        35                  40                  45              


Gly Gly Ala Leu Leu Val Leu Tyr Ala Phe Ala Leu Met Leu Val Ile 
    50                  55                  60                  


Ile Ile Leu Ile Ile Phe Ile Phe Arg Arg Asp Leu Leu Cys Pro Leu 
65                  70                  75                  80  


Gly Ala Leu Cys Leu Leu Leu Leu Met Ile Thr Leu Leu Leu Ile Ala 
                85                  90                  95      


Leu Trp Asn Leu His Gly Gln Ala Leu Tyr Leu Gly Ile Val Leu Phe 
            100                 105                 110         


Ile Phe Gly Cys Leu Leu Val Leu Gly Leu Trp Ile Tyr Leu Leu Glu 
        115                 120                 125             


Ile Leu Trp Arg Leu Gly Ala Thr Ile Trp Gln Leu Leu Ala Phe Phe 
    130                 135                 140                 


Leu Ala Phe Phe Leu Asp Ile Ile Leu Leu Ile Ile Ala Leu Tyr Leu 
145                 150                 155                 160 


Gln Gln Asn Trp Trp Thr Leu Leu Val Asp Leu Leu Trp Leu Leu Leu 
                165                 170                 175     


Phe Leu Ala Ile Leu Ile Trp Met Tyr Tyr His Gly Gln Arg His Ser 
            180                 185                 190         


Asp Glu His His His Asp Asp Ser Leu Pro His Pro Gln Gln Ala Thr 
        195                 200                 205             


Asp Asp Ser Ser Asn Gln Ser Asp Ser Asn Ser Asn Glu Gly Arg His 
    210                 215                 220                 


Leu Leu Leu Val Ser Gly Ala Gly Asp Gly Pro Pro Leu Cys Ser Gln 
225                 230                 235                 240 


Asn Leu Gly Ala Pro Gly Gly Gly Pro Asn Asn Gly Pro Gln Asp Pro 
                245                 250                 255     


Asp Asn Thr Asp Asp Asn Gly Pro Gln Asp Pro Asp Asn Thr Asp Asp 
            260                 265                 270         


Asn Gly Pro His Asp Pro Leu Pro Gln Asp Pro Asp Asn Thr Asp Asp 
        275                 280                 285             


Asn Gly Pro Gln Asp Pro Asp Asn Thr Asp Asp Asn Gly Pro His Asp 
    290                 295                 300                 


Pro Leu Pro His Asn Pro Ser Asp Ser Ala Gly Asn Asp Gly Gly Pro 
305                 310                 315                 320 


Pro Gln Leu Thr Glu Glu Val Glu Asn Lys Gly Gly Asp Gln Gly Pro 
                325                 330                 335     


Pro Leu Met Thr Asp Gly Gly Gly Gly His Ser His Asp Ser Gly His 
            340                 345                 350         


Asp Gly Ile Asp Pro His Leu Pro Thr Leu Leu Leu Gly Thr Ser Gly 
        355                 360                 365             


Ser Gly Gly Asp Asp Asp Asp Pro His Gly Pro Val Gln Leu Ser Tyr 
    370                 375                 380                 


Tyr Asp 
385     


<210>  3
<211>  570
<212>  DNA
<213>  Epstein Barr virus

<400>  3
atggatctgg atctcgaaag aggacctcct ggacctagac ggcctcctag aggaccacct       60

ctgagcagct ctattggact ggccctgctg ctgcttctgc tggctctgct gttctggctg      120

tacatcatca tgagcaactg gaccggcgga gcactgctgg tgctgtatgc ctttgctctg      180

atgctggtca tcatcatcct gatcatcttc atcttccggc gggacctgct gtgtcctctg      240

ggagcacttt gtctgttgct gctgatgatc accctcctgc tgatcgccct gtggaacctg      300

catggacagg ccctgtatct gggcatcgtg ctgttcatct tcggctgcct gctggttctc      360

ggcctgtgga tctacctgct ggaaatcctt tggagactgg gcgccaccat ctggcagctg      420

ctggcctttt tcctggcctt ctttctggat atcatcctcc tcatcattgc cctgtacctg      480

cagcagaact ggtggaccct gctggtggat ctgctttggc tgctgctctt tctggccatc      540

ctgatttgga tgtactacca cggccagcgg                                       570


<210>  4
<211>  190
<212>  PRT
<213>  Epstein Barr virus

<400>  4

Met Asp Leu Asp Leu Glu Arg Gly Pro Pro Gly Pro Arg Arg Pro Pro 
1               5                   10                  15      


Arg Gly Pro Pro Leu Ser Ser Ser Ile Gly Leu Ala Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Ala Leu Leu Phe Trp Leu Tyr Ile Ile Met Ser Asn Trp Thr 
        35                  40                  45              


Gly Gly Ala Leu Leu Val Leu Tyr Ala Phe Ala Leu Met Leu Val Ile 
    50                  55                  60                  


Ile Ile Leu Ile Ile Phe Ile Phe Arg Arg Asp Leu Leu Cys Pro Leu 
65                  70                  75                  80  


Gly Ala Leu Cys Leu Leu Leu Leu Met Ile Thr Leu Leu Leu Ile Ala 
                85                  90                  95      


Leu Trp Asn Leu His Gly Gln Ala Leu Tyr Leu Gly Ile Val Leu Phe 
            100                 105                 110         


Ile Phe Gly Cys Leu Leu Val Leu Gly Leu Trp Ile Tyr Leu Leu Glu 
        115                 120                 125             


Ile Leu Trp Arg Leu Gly Ala Thr Ile Trp Gln Leu Leu Ala Phe Phe 
    130                 135                 140                 


Leu Ala Phe Phe Leu Asp Ile Ile Leu Leu Ile Ile Ala Leu Tyr Leu 
145                 150                 155                 160 


Gln Gln Asn Trp Trp Thr Leu Leu Val Asp Leu Leu Trp Leu Leu Leu 
                165                 170                 175     


Phe Leu Ala Ile Leu Ile Trp Met Tyr Tyr His Gly Gln Arg 
            180                 185                 190 


<210>  5
<211>  2187
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion of LMP-1 from Epstein Barr virus and ISP1 from Homo 
       sapiens

<400>  5
atggatctgg atctcgaaag aggacctcct ggacctagac ggcctcctag aggaccacct       60

ctgagcagct ctattggact ggccctgctg ctgcttctgc tggctctgct gttctggctg      120

tacatcatca tgagcaactg gaccggcgga gcactgctgg tgctgtatgc ctttgctctg      180

atgctggtca tcatcatcct gatcatcttc atcttccggc gggacctgct gtgtcctctg      240

ggagcacttt gtctgttgct gctgatgatc accctcctgc tgatcgccct gtggaacctg      300

catggacagg ccctgtatct gggcatcgtg ctgttcatct tcggctgcct gctggttctc      360

ggcctgtgga tctacctgct ggaaatcctt tggagactgg gcgccaccat ctggcagctg      420

ctggcctttt tcctggcctt ctttctggat atcatcctcc tcatcattgc cctgtacctg      480

cagcagaact ggtggaccct gctggtggat ctgctttggc tgctgctctt tctggccatc      540

ctgatttgga tgtactacca cggccagcgg cctttcgccg aggacaagac ctacaagtac      600

atctgccgga acttcagcaa cttctgcaac gtggacgtgg tggaaattct gccctacctg      660

ccttgcctga ccgccagaga tcaggacaga ctgagagcca catgtaccct gagcggcaac      720

agagacacac tgtggcacct gttcaacacc ctgcagagaa ggcctggctg ggtcgagtac      780

tttatcgccg ctctgagagg ctgcgagctg gtcgatctgg ctgatgaagt ggccagcgtg      840

taccagagct accagcctag aaccagcgac cggcctcctg atcctctcga acctccatct      900

ctgcccgccg aaagacctgg acctcctaca ccagctgccg ctcacagcat cccttacaac      960

agctgcagag agaaagaacc tagctacccc atgcctgtgc aagagacaca ggccccagaa     1020

agccctggcg agaatagcga acaggctctg cagacactga gccccagagc cattcctaga     1080

aaccctgatg gcggccctct ggaaagctct agtgatctgg ccgctctgtc ccctctgaca     1140

agctctggac accaagagca ggataccgag ctgggcagca cacatacagc cggcgctaca     1200

agcagcctga caccttctag aggccccgtg tctcccagcg tgtcatttca gcctctggcc     1260

aggtctaccc ctagggcttc tagactgcct ggaccaacag gcagcgtggt gtctaccggc     1320

acaagcttca gctctagctc tcctggactg gctagtgccg gtgccgctga gggaaaacaa     1380

ggcgccgaat ctgatcaggc cgagcctatc atctgtagca gcggagcaga agcccctgcc     1440

aatagcctgc ctagcaaggt gccaaccaca ctgatgcccg tgaacacagt ggccctgaag     1500

gtgccagcta atcctgcctc cgtgtccacc gtgccttcta agctgccaac cagctctaag     1560

ccacctggcg ccgtgccatc taacgccctg acaaatcctg ctccaagcaa gctgcccatc     1620

aactccacaa gagccggcat ggtgccctct aaggtgccca catctatggt gctgaccaag     1680

gtgtccgcca gcaccgtgcc aacagatggc agctccagaa acgaggaaac ccctgccgct     1740

cctactcctg ctggcgctac aggcggatct tctgcttggc tggatagcag cagcgagaac     1800

agaggcctgg gcagcgagct ttctaaacct ggcgtgctgg cttcccaggt ggacagccca     1860

ttttccggct gctttgagga cctggctatc agcgcctcta caagcctcgg catgggacct     1920

tgtcacggcc ccgaggaaaa cgagtacaag agcgagggca ccttcggcat ccacgtggcc     1980

gagaatccta gcatccaact gctggaaggc aaccccggac ctccagctga tccagatggc     2040

ggaccaagac ctcaggccga cagaaagttc caagagcgcg aggtgccctg ccacagacct     2100

tctccaggtg ctctgtggct gcaggttgca gtgacaggcg tcctggtggt tacactgctc     2160

gtggtcctgt atagacggcg gctgcac                                         2187


<210>  6
<211>  729
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion of LMP1 from Epstein Barr virus and ISP1 from Homo sapiens

<400>  6

Met Asp Leu Asp Leu Glu Arg Gly Pro Pro Gly Pro Arg Arg Pro Pro 
1               5                   10                  15      


Arg Gly Pro Pro Leu Ser Ser Ser Ile Gly Leu Ala Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Ala Leu Leu Phe Trp Leu Tyr Ile Ile Met Ser Asn Trp Thr 
        35                  40                  45              


Gly Gly Ala Leu Leu Val Leu Tyr Ala Phe Ala Leu Met Leu Val Ile 
    50                  55                  60                  


Ile Ile Leu Ile Ile Phe Ile Phe Arg Arg Asp Leu Leu Cys Pro Leu 
65                  70                  75                  80  


Gly Ala Leu Cys Leu Leu Leu Leu Met Ile Thr Leu Leu Leu Ile Ala 
                85                  90                  95      


Leu Trp Asn Leu His Gly Gln Ala Leu Tyr Leu Gly Ile Val Leu Phe 
            100                 105                 110         


Ile Phe Gly Cys Leu Leu Val Leu Gly Leu Trp Ile Tyr Leu Leu Glu 
        115                 120                 125             


Ile Leu Trp Arg Leu Gly Ala Thr Ile Trp Gln Leu Leu Ala Phe Phe 
    130                 135                 140                 


Leu Ala Phe Phe Leu Asp Ile Ile Leu Leu Ile Ile Ala Leu Tyr Leu 
145                 150                 155                 160 


Gln Gln Asn Trp Trp Thr Leu Leu Val Asp Leu Leu Trp Leu Leu Leu 
                165                 170                 175     


Phe Leu Ala Ile Leu Ile Trp Met Tyr Tyr His Gly Gln Arg Pro Phe 
            180                 185                 190         


Ala Glu Asp Lys Thr Tyr Lys Tyr Ile Cys Arg Asn Phe Ser Asn Phe 
        195                 200                 205             


Cys Asn Val Asp Val Val Glu Ile Leu Pro Tyr Leu Pro Cys Leu Thr 
    210                 215                 220                 


Ala Arg Asp Gln Asp Arg Leu Arg Ala Thr Cys Thr Leu Ser Gly Asn 
225                 230                 235                 240 


Arg Asp Thr Leu Trp His Leu Phe Asn Thr Leu Gln Arg Arg Pro Gly 
                245                 250                 255     


Trp Val Glu Tyr Phe Ile Ala Ala Leu Arg Gly Cys Glu Leu Val Asp 
            260                 265                 270         


Leu Ala Asp Glu Val Ala Ser Val Tyr Gln Ser Tyr Gln Pro Arg Thr 
        275                 280                 285             


Ser Asp Arg Pro Pro Asp Pro Leu Glu Pro Pro Ser Leu Pro Ala Glu 
    290                 295                 300                 


Arg Pro Gly Pro Pro Thr Pro Ala Ala Ala His Ser Ile Pro Tyr Asn 
305                 310                 315                 320 


Ser Cys Arg Glu Lys Glu Pro Ser Tyr Pro Met Pro Val Gln Glu Thr 
                325                 330                 335     


Gln Ala Pro Glu Ser Pro Gly Glu Asn Ser Glu Gln Ala Leu Gln Thr 
            340                 345                 350         


Leu Ser Pro Arg Ala Ile Pro Arg Asn Pro Asp Gly Gly Pro Leu Glu 
        355                 360                 365             


Ser Ser Ser Asp Leu Ala Ala Leu Ser Pro Leu Thr Ser Ser Gly His 
    370                 375                 380                 


Gln Glu Gln Asp Thr Glu Leu Gly Ser Thr His Thr Ala Gly Ala Thr 
385                 390                 395                 400 


Ser Ser Leu Thr Pro Ser Arg Gly Pro Val Ser Pro Ser Val Ser Phe 
                405                 410                 415     


Gln Pro Leu Ala Arg Ser Thr Pro Arg Ala Ser Arg Leu Pro Gly Pro 
            420                 425                 430         


Thr Gly Ser Val Val Ser Thr Gly Thr Ser Phe Ser Ser Ser Ser Pro 
        435                 440                 445             


Gly Leu Ala Ser Ala Gly Ala Ala Glu Gly Lys Gln Gly Ala Glu Ser 
    450                 455                 460                 


Asp Gln Ala Glu Pro Ile Ile Cys Ser Ser Gly Ala Glu Ala Pro Ala 
465                 470                 475                 480 


Asn Ser Leu Pro Ser Lys Val Pro Thr Thr Leu Met Pro Val Asn Thr 
                485                 490                 495     


Val Ala Leu Lys Val Pro Ala Asn Pro Ala Ser Val Ser Thr Val Pro 
            500                 505                 510         


Ser Lys Leu Pro Thr Ser Ser Lys Pro Pro Gly Ala Val Pro Ser Asn 
        515                 520                 525             


Ala Leu Thr Asn Pro Ala Pro Ser Lys Leu Pro Ile Asn Ser Thr Arg 
    530                 535                 540                 


Ala Gly Met Val Pro Ser Lys Val Pro Thr Ser Met Val Leu Thr Lys 
545                 550                 555                 560 


Val Ser Ala Ser Thr Val Pro Thr Asp Gly Ser Ser Arg Asn Glu Glu 
                565                 570                 575     


Thr Pro Ala Ala Pro Thr Pro Ala Gly Ala Thr Gly Gly Ser Ser Ala 
            580                 585                 590         


Trp Leu Asp Ser Ser Ser Glu Asn Arg Gly Leu Gly Ser Glu Leu Ser 
        595                 600                 605             


Lys Pro Gly Val Leu Ala Ser Gln Val Asp Ser Pro Phe Ser Gly Cys 
    610                 615                 620                 


Phe Glu Asp Leu Ala Ile Ser Ala Ser Thr Ser Leu Gly Met Gly Pro 
625                 630                 635                 640 


Cys His Gly Pro Glu Glu Asn Glu Tyr Lys Ser Glu Gly Thr Phe Gly 
                645                 650                 655     


Ile His Val Ala Glu Asn Pro Ser Ile Gln Leu Leu Glu Gly Asn Pro 
            660                 665                 670         


Gly Pro Pro Ala Asp Pro Asp Gly Gly Pro Arg Pro Gln Ala Asp Arg 
        675                 680                 685             


Lys Phe Gln Glu Arg Glu Val Pro Cys His Arg Pro Ser Pro Gly Ala 
    690                 695                 700                 


Leu Trp Leu Gln Val Ala Val Thr Gly Val Leu Val Val Thr Leu Leu 
705                 710                 715                 720 


Val Val Leu Tyr Arg Arg Arg Leu His 
                725                 


<210>  7
<211>  2106
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion of LMP1 from Epstein Barr virus and IPS1 from Homo sapiens

<400>  7
atggatctgg atctcgaaag aggacctcct ggacctagac ggcctcctag aggaccacct       60

ctgagcagct ctattggact ggccctgctg ctgcttctgc tggctctgct gttctggctg      120

tacatcatca tgagcaactg gaccggcgga gcactgctgg tgctgtatgc ctttgctctg      180

atgctggtca tcatcatcct gatcatcttc atcttccggc gggacctgct gtgtcctctg      240

ggagcacttt gtctgttgct gctgatgatc accctcctgc tgatcgccct gtggaacctg      300

catggacagg ccctgtatct gggcatcgtg ctgttcatct tcggctgcct gctggttctc      360

ggcctgtgga tctacctgct ggaaatcctt tggagactgg gcgccaccat ctggcagctg      420

ctggcctttt tcctggcctt ctttctggat atcatcctcc tcatcattgc cctgtacctg      480

cagcagaact ggtggaccct gctggtggat ctgctttggc tgctgctctt tctggccatc      540

ctgatttgga tgtactacca cggccagcgg cctttcgccg aggacaagac ctacaagtac      600

atctgccgga acttcagcaa cttctgcaac gtggacgtgg tggaaattct gccctacctg      660

ccttgcctga ccgccagaga tcaggacaga ctgagagcca catgtaccct gagcggcaac      720

agagacacac tgtggcacct gttcaacacc ctgcagagaa ggcctggctg ggtcgagtac      780

tttatcgccg ctctgagagg ctgcgagctg gtcgatctgg ctgatgaagt ggccagcgtg      840

taccagagct accagcctag aaccagcgac cggcctcctg atcctctcga acctccatct      900

ctgcccgccg aaagacctgg acctcctaca ccagctgccg ctcacagcat cccttacaac      960

agctgcagag agaaagaacc tagctacccc atgcctgtgc aagagacaca ggccccagaa     1020

agccctggcg agaatagcga acaggctctg cagacactga gccccagagc cattcctaga     1080

aaccctgatg gcggccctct ggaaagctct agtgatctgg ccgctctgtc ccctctgaca     1140

agctctggac accaagagca ggataccgag ctgggcagca cacatacagc cggcgctaca     1200

agcagcctga caccttctag aggccccgtg tctcccagcg tgtcatttca gcctctggcc     1260

aggtctaccc ctagggcttc tagactgcct ggaccaacag gcagcgtggt gtctaccggc     1320

acaagcttca gctctagctc tcctggactg gctagtgccg gtgccgctga gggaaaacaa     1380

ggcgccgaat ctgatcaggc cgagcctatc atctgtagca gcggagcaga agcccctgcc     1440

aatagcctgc ctagcaaggt gccaaccaca ctgatgcccg tgaacacagt ggccctgaag     1500

gtgccagcta atcctgcctc cgtgtccacc gtgccttcta agctgccaac cagctctaag     1560

ccacctggcg ccgtgccatc taacgccctg acaaatcctg ctccaagcaa gctgcccatc     1620

aactccacaa gagccggcat ggtgccctct aaggtgccca catctatggt gctgaccaag     1680

gtgtccgcca gcaccgtgcc aacagatggc agctccagaa acgaggaaac ccctgccgct     1740

cctactcctg ctggcgctac aggcggatct tctgcttggc tggatagcag cagcgagaac     1800

agaggcctgg gcagcgagct ttctaaacct ggcgtgctgg cttcccaggt ggacagccca     1860

ttttccggct gctttgagga cctggctatc agcgcctcta caagcctcgg catgggacct     1920

tgtcacggcc ccgaggaaaa cgagtacaag agcgagggca ccttcggcat ccacgtggcc     1980

gagaatccta gcatccaact gctggaaggc aaccccggac ctccagctga tccagatggc     2040

ggaccaagac ctcaggccga cagaaagttc caagagcgcg aggtgccctg ccacagacct     2100

tctcca                                                                2106


<210>  8
<211>  702
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion of LMP1 from Epstein Barr virus and IPS1 from Homo sapiens

<400>  8

Met Asp Leu Asp Leu Glu Arg Gly Pro Pro Gly Pro Arg Arg Pro Pro 
1               5                   10                  15      


Arg Gly Pro Pro Leu Ser Ser Ser Ile Gly Leu Ala Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Ala Leu Leu Phe Trp Leu Tyr Ile Ile Met Ser Asn Trp Thr 
        35                  40                  45              


Gly Gly Ala Leu Leu Val Leu Tyr Ala Phe Ala Leu Met Leu Val Ile 
    50                  55                  60                  


Ile Ile Leu Ile Ile Phe Ile Phe Arg Arg Asp Leu Leu Cys Pro Leu 
65                  70                  75                  80  


Gly Ala Leu Cys Leu Leu Leu Leu Met Ile Thr Leu Leu Leu Ile Ala 
                85                  90                  95      


Leu Trp Asn Leu His Gly Gln Ala Leu Tyr Leu Gly Ile Val Leu Phe 
            100                 105                 110         


Ile Phe Gly Cys Leu Leu Val Leu Gly Leu Trp Ile Tyr Leu Leu Glu 
        115                 120                 125             


Ile Leu Trp Arg Leu Gly Ala Thr Ile Trp Gln Leu Leu Ala Phe Phe 
    130                 135                 140                 


Leu Ala Phe Phe Leu Asp Ile Ile Leu Leu Ile Ile Ala Leu Tyr Leu 
145                 150                 155                 160 


Gln Gln Asn Trp Trp Thr Leu Leu Val Asp Leu Leu Trp Leu Leu Leu 
                165                 170                 175     


Phe Leu Ala Ile Leu Ile Trp Met Tyr Tyr His Gly Gln Arg Pro Phe 
            180                 185                 190         


Ala Glu Asp Lys Thr Tyr Lys Tyr Ile Cys Arg Asn Phe Ser Asn Phe 
        195                 200                 205             


Cys Asn Val Asp Val Val Glu Ile Leu Pro Tyr Leu Pro Cys Leu Thr 
    210                 215                 220                 


Ala Arg Asp Gln Asp Arg Leu Arg Ala Thr Cys Thr Leu Ser Gly Asn 
225                 230                 235                 240 


Arg Asp Thr Leu Trp His Leu Phe Asn Thr Leu Gln Arg Arg Pro Gly 
                245                 250                 255     


Trp Val Glu Tyr Phe Ile Ala Ala Leu Arg Gly Cys Glu Leu Val Asp 
            260                 265                 270         


Leu Ala Asp Glu Val Ala Ser Val Tyr Gln Ser Tyr Gln Pro Arg Thr 
        275                 280                 285             


Ser Asp Arg Pro Pro Asp Pro Leu Glu Pro Pro Ser Leu Pro Ala Glu 
    290                 295                 300                 


Arg Pro Gly Pro Pro Thr Pro Ala Ala Ala His Ser Ile Pro Tyr Asn 
305                 310                 315                 320 


Ser Cys Arg Glu Lys Glu Pro Ser Tyr Pro Met Pro Val Gln Glu Thr 
                325                 330                 335     


Gln Ala Pro Glu Ser Pro Gly Glu Asn Ser Glu Gln Ala Leu Gln Thr 
            340                 345                 350         


Leu Ser Pro Arg Ala Ile Pro Arg Asn Pro Asp Gly Gly Pro Leu Glu 
        355                 360                 365             


Ser Ser Ser Asp Leu Ala Ala Leu Ser Pro Leu Thr Ser Ser Gly His 
    370                 375                 380                 


Gln Glu Gln Asp Thr Glu Leu Gly Ser Thr His Thr Ala Gly Ala Thr 
385                 390                 395                 400 


Ser Ser Leu Thr Pro Ser Arg Gly Pro Val Ser Pro Ser Val Ser Phe 
                405                 410                 415     


Gln Pro Leu Ala Arg Ser Thr Pro Arg Ala Ser Arg Leu Pro Gly Pro 
            420                 425                 430         


Thr Gly Ser Val Val Ser Thr Gly Thr Ser Phe Ser Ser Ser Ser Pro 
        435                 440                 445             


Gly Leu Ala Ser Ala Gly Ala Ala Glu Gly Lys Gln Gly Ala Glu Ser 
    450                 455                 460                 


Asp Gln Ala Glu Pro Ile Ile Cys Ser Ser Gly Ala Glu Ala Pro Ala 
465                 470                 475                 480 


Asn Ser Leu Pro Ser Lys Val Pro Thr Thr Leu Met Pro Val Asn Thr 
                485                 490                 495     


Val Ala Leu Lys Val Pro Ala Asn Pro Ala Ser Val Ser Thr Val Pro 
            500                 505                 510         


Ser Lys Leu Pro Thr Ser Ser Lys Pro Pro Gly Ala Val Pro Ser Asn 
        515                 520                 525             


Ala Leu Thr Asn Pro Ala Pro Ser Lys Leu Pro Ile Asn Ser Thr Arg 
    530                 535                 540                 


Ala Gly Met Val Pro Ser Lys Val Pro Thr Ser Met Val Leu Thr Lys 
545                 550                 555                 560 


Val Ser Ala Ser Thr Val Pro Thr Asp Gly Ser Ser Arg Asn Glu Glu 
                565                 570                 575     


Thr Pro Ala Ala Pro Thr Pro Ala Gly Ala Thr Gly Gly Ser Ser Ala 
            580                 585                 590         


Trp Leu Asp Ser Ser Ser Glu Asn Arg Gly Leu Gly Ser Glu Leu Ser 
        595                 600                 605             


Lys Pro Gly Val Leu Ala Ser Gln Val Asp Ser Pro Phe Ser Gly Cys 
    610                 615                 620                 


Phe Glu Asp Leu Ala Ile Ser Ala Ser Thr Ser Leu Gly Met Gly Pro 
625                 630                 635                 640 


Cys His Gly Pro Glu Glu Asn Glu Tyr Lys Ser Glu Gly Thr Phe Gly 
                645                 650                 655     


Ile His Val Ala Glu Asn Pro Ser Ile Gln Leu Leu Glu Gly Asn Pro 
            660                 665                 670         


Gly Pro Pro Ala Asp Pro Asp Gly Gly Pro Arg Pro Gln Ala Asp Arg 
        675                 680                 685             


Lys Phe Gln Glu Arg Glu Val Pro Cys His Arg Pro Ser Pro 
    690                 695                 700         


<210>  9
<211>  1953
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion of LMP1 of Epstein Barr virus and IPS1 from Homo sapiens

<400>  9
atggatctgg atctcgaaag aggacctcct ggacctagac ggcctcctag aggaccacct       60

ctgagcagct ctattggact ggccctgctg ctgcttctgc tggctctgct gttctggctg      120

tacatcatca tgagcaactg gaccggcgga gcactgctgg tgctgtatgc ctttgctctg      180

atgctggtca tcatcatcct gatcatcttc atcttccggc gggacctgct gtgtcctctg      240

ggagcacttt gtctgttgct gctgatgatc accctcctgc tgatcgccct gtggaacctg      300

catggacagg ccctgtatct gggcatcgtg ctgttcatct tcggctgcct gctggttctc      360

ggcctgtgga tctacctgct ggaaatcctt tggagactgg gcgccaccat ctggcagctg      420

ctggcctttt tcctggcctt ctttctggat atcatcctcc tcatcattgc cctgtacctg      480

cagcagaact ggtggaccct gctggtggat ctgctttggc tgctgctctt tctggccatc      540

ctgatttgga tgtactacca cggccagcgg cctttcgccg aggacaagac ctacaagtac      600

atctgccgga acttcagcaa cttctgcaac gtggacgtgg tggaaattct gccctacctg      660

ccttgcctga ccgccagaga tcaggacaga ctgagagcca catgtaccct gagcggcaac      720

agagacacac tgtggcacct gttcaacacc ctgcagagaa ggcctggctg ggtcgagtac      780

tttatcgccg ctctgagagg ctgcgagctg gtcgatctgg ctgatgaagt ggccagcgtg      840

taccagagct accagcctag aaccagcgac cggggcgaga atagcgaaca ggctctgcag      900

acactgagcc ccagagccat tcctagaaac cctgatggcg gccctctgga aagctctagt      960

gatctggccg ctctgtcccc tctgacaagc tctggacacc aagagcagga taccgagctg     1020

ggcagcacac atacagccgg cgctacaagc agcctgacac cttctagagg ccccgtgtct     1080

cccagcgtgt catttcagcc tctggccagg tctaccccta gggcttctag actgcctgga     1140

ccaacaggca gcgtggtgtc taccggcaca agcttcagct ctagctctcc tggactggct     1200

agtgccggtg ccgctgaggg aaaacaaggc gccgaatctg atcaggccga gcctatcatc     1260

tgtagcagcg gagcagaagc ccctgccaat agcctgccta gcaaggtgcc aaccacactg     1320

atgcccgtga acacagtggc cctgaaggtg ccagctaatc ctgcctccgt gtccaccgtg     1380

ccttctaagc tgccaaccag ctctaagcca cctggcgccg tgccatctaa cgccctgaca     1440

aatcctgctc caagcaagct gcccatcaac tccacaagag ccggcatggt gccctctaag     1500

gtgcccacat ctatggtgct gaccaaggtg tccgccagca ccgtgccaac agatggcagc     1560

tccagaaacg aggaaacccc tgccgctcct actcctgctg gcgctacagg cggatcttct     1620

gcttggctgg atagcagcag cgagaacaga ggcctgggca gcgagctttc taaacctggc     1680

gtgctggctt cccaggtgga cagcccattt tccggctgct ttgaggacct ggctatcagc     1740

gcctctacaa gcctcggcat gggaccttgt cacggccccg aggaaaacga gtacaagagc     1800

gagggcacct tcggcatcca cgtggccgag aatcctagca tccaactgct ggaaggcaac     1860

cccggacctc cagctgatcc agatggcgga ccaagacctc aggccgacag aaagttccaa     1920

gagcgcgagg tgccctgcca cagaccttct cca                                  1953


<210>  10
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fustion of LMP1 of Epstein Barr virus and IPS1 of Homo sapiens

<400>  10

Met Asp Leu Asp Leu Glu Arg Gly Pro Pro Gly Pro Arg Arg Pro Pro 
1               5                   10                  15      


Arg Gly Pro Pro Leu Ser Ser Ser Ile Gly Leu Ala Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Ala Leu Leu Phe Trp Leu Tyr Ile Ile Met Ser Asn Trp Thr 
        35                  40                  45              


Gly Gly Ala Leu Leu Val Leu Tyr Ala Phe Ala Leu Met Leu Val Ile 
    50                  55                  60                  


Ile Ile Leu Ile Ile Phe Ile Phe Arg Arg Asp Leu Leu Cys Pro Leu 
65                  70                  75                  80  


Gly Ala Leu Cys Leu Leu Leu Leu Met Ile Thr Leu Leu Leu Ile Ala 
                85                  90                  95      


Leu Trp Asn Leu His Gly Gln Ala Leu Tyr Leu Gly Ile Val Leu Phe 
            100                 105                 110         


Ile Phe Gly Cys Leu Leu Val Leu Gly Leu Trp Ile Tyr Leu Leu Glu 
        115                 120                 125             


Ile Leu Trp Arg Leu Gly Ala Thr Ile Trp Gln Leu Leu Ala Phe Phe 
    130                 135                 140                 


Leu Ala Phe Phe Leu Asp Ile Ile Leu Leu Ile Ile Ala Leu Tyr Leu 
145                 150                 155                 160 


Gln Gln Asn Trp Trp Thr Leu Leu Val Asp Leu Leu Trp Leu Leu Leu 
                165                 170                 175     


Phe Leu Ala Ile Leu Ile Trp Met Tyr Tyr His Gly Gln Arg Pro Phe 
            180                 185                 190         


Ala Glu Asp Lys Thr Tyr Lys Tyr Ile Cys Arg Asn Phe Ser Asn Phe 
        195                 200                 205             


Cys Asn Val Asp Val Val Glu Ile Leu Pro Tyr Leu Pro Cys Leu Thr 
    210                 215                 220                 


Ala Arg Asp Gln Asp Arg Leu Arg Ala Thr Cys Thr Leu Ser Gly Asn 
225                 230                 235                 240 


Arg Asp Thr Leu Trp His Leu Phe Asn Thr Leu Gln Arg Arg Pro Gly 
                245                 250                 255     


Trp Val Glu Tyr Phe Ile Ala Ala Leu Arg Gly Cys Glu Leu Val Asp 
            260                 265                 270         


Leu Ala Asp Glu Val Ala Ser Val Tyr Gln Ser Tyr Gln Pro Arg Thr 
        275                 280                 285             


Ser Asp Arg Gly Glu Asn Ser Glu Gln Ala Leu Gln Thr Leu Ser Pro 
    290                 295                 300                 


Arg Ala Ile Pro Arg Asn Pro Asp Gly Gly Pro Leu Glu Ser Ser Ser 
305                 310                 315                 320 


Asp Leu Ala Ala Leu Ser Pro Leu Thr Ser Ser Gly His Gln Glu Gln 
                325                 330                 335     


Asp Thr Glu Leu Gly Ser Thr His Thr Ala Gly Ala Thr Ser Ser Leu 
            340                 345                 350         


Thr Pro Ser Arg Gly Pro Val Ser Pro Ser Val Ser Phe Gln Pro Leu 
        355                 360                 365             


Ala Arg Ser Thr Pro Arg Ala Ser Arg Leu Pro Gly Pro Thr Gly Ser 
    370                 375                 380                 


Val Val Ser Thr Gly Thr Ser Phe Ser Ser Ser Ser Pro Gly Leu Ala 
385                 390                 395                 400 


Ser Ala Gly Ala Ala Glu Gly Lys Gln Gly Ala Glu Ser Asp Gln Ala 
                405                 410                 415     


Glu Pro Ile Ile Cys Ser Ser Gly Ala Glu Ala Pro Ala Asn Ser Leu 
            420                 425                 430         


Pro Ser Lys Val Pro Thr Thr Leu Met Pro Val Asn Thr Val Ala Leu 
        435                 440                 445             


Lys Val Pro Ala Asn Pro Ala Ser Val Ser Thr Val Pro Ser Lys Leu 
    450                 455                 460                 


Pro Thr Ser Ser Lys Pro Pro Gly Ala Val Pro Ser Asn Ala Leu Thr 
465                 470                 475                 480 


Asn Pro Ala Pro Ser Lys Leu Pro Ile Asn Ser Thr Arg Ala Gly Met 
                485                 490                 495     


Val Pro Ser Lys Val Pro Thr Ser Met Val Leu Thr Lys Val Ser Ala 
            500                 505                 510         


Ser Thr Val Pro Thr Asp Gly Ser Ser Arg Asn Glu Glu Thr Pro Ala 
        515                 520                 525             


Ala Pro Thr Pro Ala Gly Ala Thr Gly Gly Ser Ser Ala Trp Leu Asp 
    530                 535                 540                 


Ser Ser Ser Glu Asn Arg Gly Leu Gly Ser Glu Leu Ser Lys Pro Gly 
545                 550                 555                 560 


Val Leu Ala Ser Gln Val Asp Ser Pro Phe Ser Gly Cys Phe Glu Asp 
                565                 570                 575     


Leu Ala Ile Ser Ala Ser Thr Ser Leu Gly Met Gly Pro Cys His Gly 
            580                 585                 590         


Pro Glu Glu Asn Glu Tyr Lys Ser Glu Gly Thr Phe Gly Ile His Val 
        595                 600                 605             


Ala Glu Asn Pro Ser Ile Gln Leu Leu Glu Gly Asn Pro Gly Pro Pro 
    610                 615                 620                 


Ala Asp Pro Asp Gly Gly Pro Arg Pro Gln Ala Asp Arg Lys Phe Gln 
625                 630                 635                 640 


Glu Arg Glu Val Pro Cys His Arg Pro Ser Pro 
                645                 650     


<210>  11
<211>  2109
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fustion of LMP1 of Epstein Barr virus and IPS1 of Homo sapiens

<400>  11
atggatctgg atctcgaaag aggacctcct ggacctagac ggcctcctag aggaccacct       60

ctgagcagct ctattggact ggccctgctg ctgcttctgc tggctctgct gttctggctg      120

tacatcatca tgagcaactg gaccggcgga gcactgctgg tgctgtatgc ctttgctctg      180

atgctggtca tcatcatcct gatcatcttc atcttccggc gggacctgct gtgtcctctg      240

ggagcacttt gtctgttgct gctgatgatc accctcctgc tgatcgccct gtggaacctg      300

catggacagg ccctgtatct gggcatcgtg ctgttcatct tcggctgcct gctggttctc      360

ggcctgtgga tctacctgct ggaaatcctt tggagactgg gcgccaccat ctggcagctg      420

ctggcctttt tcctggcctt ctttctggat atcatcctcc tcatcattgc cctgtacctg      480

cagcagaact ggtggaccct gctggtggat ctgctttggc tgctgctctt tctggccatc      540

ctgatttgga tgtactacca cggccagcgg cccagcccca gacactgccc cgtggagaga      600

gagcagttca agagagacgc ccagcccaga cccggcggcg accccgacgc cccccccggc      660

cccaacggcg agctgctgca gatcagcccc aacgaggccg tgcacatcgg cttcaccggc      720

gagagcaagt acgagaacga ggagcccggc cactgccccg gcatgggcct gagcaccagc      780

gccagcatcg ccctggacga gttctgcggc agcttcccca gcgacgtgca gagcgccctg      840

gtgggcccca agagcctgga gagcggcctg ggcagaaacg agagcagcag cgacctgtgg      900

gccagcagcg gcggcaccgc cggcgccccc acccccgccg cccccaccga ggagaacaga      960

agcagcggcg acacccccgt gaccagcgcc agcgtgaaga ccctggtgat gagcaccccc     1020

gtgaagagcc ccgtgatggg cgccagaacc agcaacatcc ccctgaagag ccccgccccc     1080

aacaccctgg ccaacagccc cgtggccggc ccccccaaga gcagcacccc cctgaagagc     1140

cccgtgacca gcgtgagcgc ccccaacgcc cccgtgaagc tggccgtgac caacgtgccc     1200

atgctgacca cccccgtgaa gagccccctg agcaacgccc ccgccgaggc cggcagcagc     1260

tgcatcatcc ccgaggccca ggacagcgag gccggccaga agggcgaggc cgccggcgcc     1320

agcgccctgg gccccagcag cagcagcttc agcaccggca ccagcgtggt gagcggcacc     1380

cccggccccc tgagaagcgc cagacccacc agcagagccc tgccccagtt cagcgtgagc     1440

cccagcgtgc ccggcagaag ccccaccctg agcagcaccg ccggcgccac ccacaccagc     1500

ggcctggaga ccgaccagga gcagcacggc agcagcaccc tgcccagcct ggccgccctg     1560

gacagcagca gcgagctgcc cggcggcgac cccaacagac ccatcgccag acccagcctg     1620

acccagctgg cccaggagag caacgagggc cccagcgagc ccgcccagac cgagcaggtg     1680

cccatgccct acagccccga gaaggagaga tgcagcaact accccatcag ccacgccgcc     1740

gcccccaccc cccccggccc cagagaggcc cccctgagcc cccccgagct gcccgacccc     1800

cccagagaca gcaccagacc ccagtacagc cagtacgtga gcgccgtgga ggacgccctg     1860

gacgtgctgg agtgcggcag actggccgcc atcttctacg aggtgtgggg ccccagaaga     1920

cagctgacca acttcctgca ctggctgacc gacagaaacg gcagcctgac ctgcaccgcc     1980

agactgagag accaggacag agccaccctg tgccccctgt accccctgat cgaggtggtg     2040

gacgtgaact gcttcaacag cttcaacaga tgcatctaca agtacaccaa ggacgaggcc     2100

ttccccatg                                                             2109


<210>  12
<211>  703
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion of LMP1 of Epstein Barr Virus and IPS1 of Homo sapiens

<400>  12

Met Asp Leu Asp Leu Glu Arg Gly Pro Pro Gly Pro Arg Arg Pro Pro 
1               5                   10                  15      


Arg Gly Pro Pro Leu Ser Ser Ser Ile Gly Leu Ala Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Ala Leu Leu Phe Trp Leu Tyr Ile Ile Met Ser Asn Trp Thr 
        35                  40                  45              


Gly Gly Ala Leu Leu Val Leu Tyr Ala Phe Ala Leu Met Leu Val Ile 
    50                  55                  60                  


Ile Ile Leu Ile Ile Phe Ile Phe Arg Arg Asp Leu Leu Cys Pro Leu 
65                  70                  75                  80  


Gly Ala Leu Cys Leu Leu Leu Leu Met Ile Thr Leu Leu Leu Ile Ala 
                85                  90                  95      


Leu Trp Asn Leu His Gly Gln Ala Leu Tyr Leu Gly Ile Val Leu Phe 
            100                 105                 110         


Ile Phe Gly Cys Leu Leu Val Leu Gly Leu Trp Ile Tyr Leu Leu Glu 
        115                 120                 125             


Ile Leu Trp Arg Leu Gly Ala Thr Ile Trp Gln Leu Leu Ala Phe Phe 
    130                 135                 140                 


Leu Ala Phe Phe Leu Asp Ile Ile Leu Leu Ile Ile Ala Leu Tyr Leu 
145                 150                 155                 160 


Gln Gln Asn Trp Trp Thr Leu Leu Val Asp Leu Leu Trp Leu Leu Leu 
                165                 170                 175     


Phe Leu Ala Ile Leu Ile Trp Met Tyr Tyr His Gly Gln Arg Pro Ser 
            180                 185                 190         


Pro Arg His Cys Pro Val Glu Arg Glu Gln Phe Lys Arg Asp Ala Gln 
        195                 200                 205             


Pro Arg Pro Gly Gly Asp Pro Asp Ala Pro Pro Gly Pro Asn Gly Glu 
    210                 215                 220                 


Leu Leu Gln Ile Ser Pro Asn Glu Ala Val His Ile Gly Phe Thr Gly 
225                 230                 235                 240 


Glu Ser Lys Tyr Glu Asn Glu Glu Pro Gly His Cys Pro Gly Met Gly 
                245                 250                 255     


Leu Ser Thr Ser Ala Ser Ile Ala Leu Asp Glu Phe Cys Gly Ser Phe 
            260                 265                 270         


Pro Ser Asp Val Gln Ser Ala Leu Val Gly Pro Lys Ser Leu Glu Ser 
        275                 280                 285             


Gly Leu Gly Arg Asn Glu Ser Ser Ser Asp Leu Trp Ala Ser Ser Gly 
    290                 295                 300                 


Gly Thr Ala Gly Ala Pro Thr Pro Ala Ala Pro Thr Glu Glu Asn Arg 
305                 310                 315                 320 


Ser Ser Gly Asp Thr Pro Val Thr Ser Ala Ser Val Lys Thr Leu Val 
                325                 330                 335     


Met Ser Thr Pro Val Lys Ser Pro Val Met Gly Ala Arg Thr Ser Asn 
            340                 345                 350         


Ile Pro Leu Lys Ser Pro Ala Pro Asn Thr Leu Ala Asn Ser Pro Val 
        355                 360                 365             


Ala Gly Pro Pro Lys Ser Ser Thr Pro Leu Lys Ser Pro Val Thr Ser 
    370                 375                 380                 


Val Ser Ala Pro Asn Ala Pro Val Lys Leu Ala Val Thr Asn Val Pro 
385                 390                 395                 400 


Met Leu Thr Thr Pro Val Lys Ser Pro Leu Ser Asn Ala Pro Ala Glu 
                405                 410                 415     


Ala Gly Ser Ser Cys Ile Ile Pro Glu Ala Gln Asp Ser Glu Ala Gly 
            420                 425                 430         


Gln Lys Gly Glu Ala Ala Gly Ala Ser Ala Leu Gly Pro Ser Ser Ser 
        435                 440                 445             


Ser Phe Ser Thr Gly Thr Ser Val Val Ser Gly Thr Pro Gly Pro Leu 
    450                 455                 460                 


Arg Ser Ala Arg Pro Thr Ser Arg Ala Leu Pro Gln Phe Ser Val Ser 
465                 470                 475                 480 


Pro Ser Val Pro Gly Arg Ser Pro Thr Leu Ser Ser Thr Ala Gly Ala 
                485                 490                 495     


Thr His Thr Ser Gly Leu Glu Thr Asp Gln Glu Gln His Gly Ser Ser 
            500                 505                 510         


Thr Leu Pro Ser Leu Ala Ala Leu Asp Ser Ser Ser Glu Leu Pro Gly 
        515                 520                 525             


Gly Asp Pro Asn Arg Pro Ile Ala Arg Pro Ser Leu Thr Gln Leu Ala 
    530                 535                 540                 


Gln Glu Ser Asn Glu Gly Pro Ser Glu Pro Ala Gln Thr Glu Gln Val 
545                 550                 555                 560 


Pro Met Pro Tyr Ser Pro Glu Lys Glu Arg Cys Ser Asn Tyr Pro Ile 
                565                 570                 575     


Ser His Ala Ala Ala Pro Thr Pro Pro Gly Pro Arg Glu Ala Pro Leu 
            580                 585                 590         


Ser Pro Pro Glu Leu Pro Asp Pro Pro Arg Asp Ser Thr Arg Pro Gln 
        595                 600                 605             


Tyr Ser Gln Tyr Val Ser Ala Val Glu Asp Ala Leu Asp Val Leu Glu 
    610                 615                 620                 


Cys Gly Arg Leu Ala Ala Ile Phe Tyr Glu Val Trp Gly Pro Arg Arg 
625                 630                 635                 640 


Gln Leu Thr Asn Phe Leu His Trp Leu Thr Asp Arg Asn Gly Ser Leu 
                645                 650                 655     


Thr Cys Thr Ala Arg Leu Arg Asp Gln Asp Arg Ala Thr Leu Cys Pro 
            660                 665                 670         


Leu Tyr Pro Leu Ile Glu Val Val Asp Val Asn Cys Phe Asn Ser Phe 
        675                 680                 685             


Asn Arg Cys Ile Tyr Lys Tyr Thr Lys Asp Glu Ala Phe Pro Met 
    690                 695                 700             


<210>  13
<211>  2694
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion of LMP1 of Epstein Barr virus and IPS1 of Homo sapiens

<400>  13
atggatctgg acctggaaag aggacctcct ggacctagac ggcctcctag aggaccacct       60

ctgagcagct ctattggact ggccctgctg ctgcttctgc tggctctgct gttctggctg      120

tacatcatca tgagcaactg gaccggcgga gcactgctgg tgctgtatgc ctttgctctg      180

atgctggtca tcatcatcct gatcatcttc atcttccggc gggacctgct gtgtcctctg      240

ggagcacttt gtctgttgct gctgatgatc accctcctgc tgatcgccct gtggaacctg      300

catggacagg ccctgtatct gggaatcgtg ctgttcatct tcggctgcct gctggttctc      360

ggcctgtgga tctacctgct ggaaatcctt tggagactgg gcgccaccat ctggcagctg      420

ctggcctttt tcctggcctt ctttctggat atcatcctcc tcatcattgc cctgtacctg      480

cagcagaact ggtggaccct gctggtggat ctgctttggc tgctgctctt tctggccatc      540

ctgatttgga tgtactacca cggccagcgg cacagcgacg aacaccacca tgatgacagc      600

ctgcctcatc ctcagcaggc caccgacgat agcagcaacc agagcgacag caacagcaac      660

gagggcagac atctgctgct ggtgtctggt gctggcgacg gacctcctct gtgttctcaa      720

aatcttggcg cccctggcgg cggaccaaac aatggacctc aggaccccga caacaccgac      780

gacaatggcc ctcaagatcc tgataatacc gatgacaacg gcccacacga ccctctgcct      840

caagacccag ataacacaga cgataacggt ccacaagatc cggacaatac tgacgataat      900

ggaccccacg atccactgcc tcacaaccct agcgatagcg ccggaaatga tggcggacct      960

ccacagctga ccgaggaagt ggaaaacaaa ggcggagatc agggccctcc tctgatgacc     1020

gatggcggag gtggacactc tcacgattct ggccacgacg gcatcgaccc tcatctgcct     1080

acactgctgc tcggcacatc tggctctggc ggcgacgatg atgatcctca tggacctgtg     1140

cagctgagct actacgaccc tttcgccgag gacaagacct acaagtacat ctgccggaac     1200

ttcagcaact tctgcaacgt ggacgtggtg gaaattctgc cctacctgcc ttgcctgacc     1260

gccagagatc aggacagact gagagccaca tgtaccctga gcggcaacag agacacactg     1320

tggcacctgt tcaacaccct gcagagaagg cctggctggg tcgagtactt tatcgccgct     1380

ctgagaggct gcgagctggt cgatctggct gatgaagtgg ccagcgtgta ccagagctac     1440

cagcctagaa ccagcgaccg gcctcctgat cctctcgaac ctccatctct gcccgccgaa     1500

agacctggac ctcctacacc agctgccgct cacagcatcc cttacaacag ctgcagagag     1560

aaagaaccta gctaccccat gcctgtgcaa gagacacagg ccccagaaag ccctggcgag     1620

aatagcgaac aggctctgca gacactgagc cccagagcca ttcctagaaa ccctgatggc     1680

ggccctctgg aaagctctag tgatctggcc gctctgtccc ctctgacaag ctctggacac     1740

caagagcagg ataccgagct gggcagcaca catacagccg gcgctacaag cagcctgaca     1800

ccttctagag gccccgtgtc tcccagcgtg tcatttcagc ctctggccag gtctacccct     1860

agggcttcta gactgcctgg accaacaggc agcgtggtgt ctaccggcac aagcttcagc     1920

tctagctctc ctggactggc tagtgccggt gccgctgagg gaaaacaagg cgccgaatct     1980

gatcaggccg agcctatcat ctgtagcagc ggagcagaag cccctgccaa tagcctgcct     2040

agcaaggtgc caaccacact gatgcccgtg aacacagtgg ccctgaaggt gccagctaat     2100

cctgcctccg tgtccaccgt gccttctaag ctgccaacca gctctaagcc acctggcgcc     2160

gtgccatcta acgccctgac aaatcctgct ccaagcaagc tgcccatcaa ctccacaaga     2220

gccggcatgg tgccctctaa ggtgcccaca tctatggtgc tgaccaaggt gtccgccagc     2280

accgtgccaa cagatggcag ctccagaaac gaggaaaccc ctgccgctcc tactcctgct     2340

ggcgctacag gcggatcttc tgcttggctg gatagcagca gcgagaacag aggcctgggc     2400

agcgagcttt ctaaacctgg cgtgctggct tcccaggtgg acagcccatt ttccggctgc     2460

tttgaggacc tggctatcag cgcctctaca agcctcggca tgggaccttg tcacggcccc     2520

gaggaaaacg agtacaagag cgagggcacc ttcggcatcc acgtggccga gaatcctagc     2580

atccaactgc tggaaggcaa ccccggacct ccagctgatc cagatggcgg accaagacct     2640

caggccgaca gaaagttcca agagcgcgag gtgccctgcc acagaccttc tcca           2694


<210>  14
<211>  898
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion of LMP1 of Epstein Barr virus and IPS1 of Homo sapiens

<400>  14

Met Asp Leu Asp Leu Glu Arg Gly Pro Pro Gly Pro Arg Arg Pro Pro 
1               5                   10                  15      


Arg Gly Pro Pro Leu Ser Ser Ser Ile Gly Leu Ala Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Ala Leu Leu Phe Trp Leu Tyr Ile Ile Met Ser Asn Trp Thr 
        35                  40                  45              


Gly Gly Ala Leu Leu Val Leu Tyr Ala Phe Ala Leu Met Leu Val Ile 
    50                  55                  60                  


Ile Ile Leu Ile Ile Phe Ile Phe Arg Arg Asp Leu Leu Cys Pro Leu 
65                  70                  75                  80  


Gly Ala Leu Cys Leu Leu Leu Leu Met Ile Thr Leu Leu Leu Ile Ala 
                85                  90                  95      


Leu Trp Asn Leu His Gly Gln Ala Leu Tyr Leu Gly Ile Val Leu Phe 
            100                 105                 110         


Ile Phe Gly Cys Leu Leu Val Leu Gly Leu Trp Ile Tyr Leu Leu Glu 
        115                 120                 125             


Ile Leu Trp Arg Leu Gly Ala Thr Ile Trp Gln Leu Leu Ala Phe Phe 
    130                 135                 140                 


Leu Ala Phe Phe Leu Asp Ile Ile Leu Leu Ile Ile Ala Leu Tyr Leu 
145                 150                 155                 160 


Gln Gln Asn Trp Trp Thr Leu Leu Val Asp Leu Leu Trp Leu Leu Leu 
                165                 170                 175     


Phe Leu Ala Ile Leu Ile Trp Met Tyr Tyr His Gly Gln Arg His Ser 
            180                 185                 190         


Asp Glu His His His Asp Asp Ser Leu Pro His Pro Gln Gln Ala Thr 
        195                 200                 205             


Asp Asp Ser Ser Asn Gln Ser Asp Ser Asn Ser Asn Glu Gly Arg His 
    210                 215                 220                 


Leu Leu Leu Val Ser Gly Ala Gly Asp Gly Pro Pro Leu Cys Ser Gln 
225                 230                 235                 240 


Asn Leu Gly Ala Pro Gly Gly Gly Pro Asn Asn Gly Pro Gln Asp Pro 
                245                 250                 255     


Asp Asn Thr Asp Asp Asn Gly Pro Gln Asp Pro Asp Asn Thr Asp Asp 
            260                 265                 270         


Asn Gly Pro His Asp Pro Leu Pro Gln Asp Pro Asp Asn Thr Asp Asp 
        275                 280                 285             


Asn Gly Pro Gln Asp Pro Asp Asn Thr Asp Asp Asn Gly Pro His Asp 
    290                 295                 300                 


Pro Leu Pro His Asn Pro Ser Asp Ser Ala Gly Asn Asp Gly Gly Pro 
305                 310                 315                 320 


Pro Gln Leu Thr Glu Glu Val Glu Asn Lys Gly Gly Asp Gln Gly Pro 
                325                 330                 335     


Pro Leu Met Thr Asp Gly Gly Gly Gly His Ser His Asp Ser Gly His 
            340                 345                 350         


Asp Gly Ile Asp Pro His Leu Pro Thr Leu Leu Leu Gly Thr Ser Gly 
        355                 360                 365             


Ser Gly Gly Asp Asp Asp Asp Pro His Gly Pro Val Gln Leu Ser Tyr 
    370                 375                 380                 


Tyr Asp Pro Phe Ala Glu Asp Lys Thr Tyr Lys Tyr Ile Cys Arg Asn 
385                 390                 395                 400 


Phe Ser Asn Phe Cys Asn Val Asp Val Val Glu Ile Leu Pro Tyr Leu 
                405                 410                 415     


Pro Cys Leu Thr Ala Arg Asp Gln Asp Arg Leu Arg Ala Thr Cys Thr 
            420                 425                 430         


Leu Ser Gly Asn Arg Asp Thr Leu Trp His Leu Phe Asn Thr Leu Gln 
        435                 440                 445             


Arg Arg Pro Gly Trp Val Glu Tyr Phe Ile Ala Ala Leu Arg Gly Cys 
    450                 455                 460                 


Glu Leu Val Asp Leu Ala Asp Glu Val Ala Ser Val Tyr Gln Ser Tyr 
465                 470                 475                 480 


Gln Pro Arg Thr Ser Asp Arg Pro Pro Asp Pro Leu Glu Pro Pro Ser 
                485                 490                 495     


Leu Pro Ala Glu Arg Pro Gly Pro Pro Thr Pro Ala Ala Ala His Ser 
            500                 505                 510         


Ile Pro Tyr Asn Ser Cys Arg Glu Lys Glu Pro Ser Tyr Pro Met Pro 
        515                 520                 525             


Val Gln Glu Thr Gln Ala Pro Glu Ser Pro Gly Glu Asn Ser Glu Gln 
    530                 535                 540                 


Ala Leu Gln Thr Leu Ser Pro Arg Ala Ile Pro Arg Asn Pro Asp Gly 
545                 550                 555                 560 


Gly Pro Leu Glu Ser Ser Ser Asp Leu Ala Ala Leu Ser Pro Leu Thr 
                565                 570                 575     


Ser Ser Gly His Gln Glu Gln Asp Thr Glu Leu Gly Ser Thr His Thr 
            580                 585                 590         


Ala Gly Ala Thr Ser Ser Leu Thr Pro Ser Arg Gly Pro Val Ser Pro 
        595                 600                 605             


Ser Val Ser Phe Gln Pro Leu Ala Arg Ser Thr Pro Arg Ala Ser Arg 
    610                 615                 620                 


Leu Pro Gly Pro Thr Gly Ser Val Val Ser Thr Gly Thr Ser Phe Ser 
625                 630                 635                 640 


Ser Ser Ser Pro Gly Leu Ala Ser Ala Gly Ala Ala Glu Gly Lys Gln 
                645                 650                 655     


Gly Ala Glu Ser Asp Gln Ala Glu Pro Ile Ile Cys Ser Ser Gly Ala 
            660                 665                 670         


Glu Ala Pro Ala Asn Ser Leu Pro Ser Lys Val Pro Thr Thr Leu Met 
        675                 680                 685             


Pro Val Asn Thr Val Ala Leu Lys Val Pro Ala Asn Pro Ala Ser Val 
    690                 695                 700                 


Ser Thr Val Pro Ser Lys Leu Pro Thr Ser Ser Lys Pro Pro Gly Ala 
705                 710                 715                 720 


Val Pro Ser Asn Ala Leu Thr Asn Pro Ala Pro Ser Lys Leu Pro Ile 
                725                 730                 735     


Asn Ser Thr Arg Ala Gly Met Val Pro Ser Lys Val Pro Thr Ser Met 
            740                 745                 750         


Val Leu Thr Lys Val Ser Ala Ser Thr Val Pro Thr Asp Gly Ser Ser 
        755                 760                 765             


Arg Asn Glu Glu Thr Pro Ala Ala Pro Thr Pro Ala Gly Ala Thr Gly 
    770                 775                 780                 


Gly Ser Ser Ala Trp Leu Asp Ser Ser Ser Glu Asn Arg Gly Leu Gly 
785                 790                 795                 800 


Ser Glu Leu Ser Lys Pro Gly Val Leu Ala Ser Gln Val Asp Ser Pro 
                805                 810                 815     


Phe Ser Gly Cys Phe Glu Asp Leu Ala Ile Ser Ala Ser Thr Ser Leu 
            820                 825                 830         


Gly Met Gly Pro Cys His Gly Pro Glu Glu Asn Glu Tyr Lys Ser Glu 
        835                 840                 845             


Gly Thr Phe Gly Ile His Val Ala Glu Asn Pro Ser Ile Gln Leu Leu 
    850                 855                 860                 


Glu Gly Asn Pro Gly Pro Pro Ala Asp Pro Asp Gly Gly Pro Arg Pro 
865                 870                 875                 880 


Gln Ala Asp Arg Lys Phe Gln Glu Arg Glu Val Pro Cys His Arg Pro 
                885                 890                 895     


Ser Pro 
        


<210>  15
<211>  2541
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LMP1 of Epstein Barr virus and IPS1 of Homo sapiens

<400>  15
atggatctgg acctggaaag aggacctcct ggacctagac ggcctcctag aggaccacct       60

ctgagcagct ctattggact ggccctgctg ctgcttctgc tggctctgct gttctggctg      120

tacatcatca tgagcaactg gaccggcgga gcactgctgg tgctgtatgc ctttgctctg      180

atgctggtca tcatcatcct gatcatcttc atcttccggc gggacctgct gtgtcctctg      240

ggagcacttt gtctgttgct gctgatgatc accctcctgc tgatcgccct gtggaacctg      300

catggacagg ccctgtatct gggaatcgtg ctgttcatct tcggctgcct gctggttctc      360

ggcctgtgga tctacctgct ggaaatcctt tggagactgg gcgccaccat ctggcagctg      420

ctggcctttt tcctggcctt ctttctggat atcatcctcc tcatcattgc cctgtacctg      480

cagcagaact ggtggaccct gctggtggat ctgctttggc tgctgctctt tctggccatc      540

ctgatttgga tgtactacca cggccagcgg cacagcgacg aacaccacca tgatgacagc      600

ctgcctcatc ctcagcaggc caccgacgat agcagcaacc agagcgacag caacagcaac      660

gagggcagac atctgctgct ggtgtctggt gctggcgacg gacctcctct gtgttctcaa      720

aatcttggcg cccctggcgg cggaccaaac aatggacctc aggaccccga caacaccgac      780

gacaatggcc ctcaagatcc tgataatacc gatgacaacg gcccacacga ccctctgcct      840

caagacccag ataacacaga cgataacggt ccacaagatc cggacaatac tgacgataat      900

ggaccccacg atccactgcc tcacaaccct agcgatagcg ccggaaatga tggcggacct      960

ccacagctga ccgaggaagt ggaaaacaaa ggcggagatc agggccctcc tctgatgacc     1020

gatggcggag gtggacactc tcacgattct ggccacgacg gcatcgaccc tcatctgcct     1080

acactgctgc tcggcacatc tggctctggc ggcgacgatg atgatcctca tggacctgtg     1140

cagctgagct actacgaccc tttcgccgag gacaagacct acaagtacat ctgccggaac     1200

ttcagcaact tctgcaacgt ggacgtggtg gaaattctgc cctacctgcc ttgcctgacc     1260

gccagagatc aggacagact gagagccaca tgtaccctga gcggcaacag agacacactg     1320

tggcacctgt tcaacaccct gcagagaagg cctggctggg tcgagtactt tatcgccgct     1380

ctgagaggct gcgagctggt cgatctggct gatgaagtgg ccagcgtgta ccagagctac     1440

cagcctagaa ccagcgaccg gggcgagaat agcgaacagg ctctgcagac actgagcccc     1500

agagccattc ctagaaaccc tgatggcggc cctctggaaa gctctagtga tctggccgct     1560

ctgtcccctc tgacaagctc tggacaccaa gagcaggata ccgagctggg cagcacacat     1620

acagccggcg ctacaagcag cctgacacct tctagaggcc ccgtgtctcc cagcgtgtca     1680

tttcagcctc tggccaggtc tacccctagg gcttctagac tgcctggacc aacaggcagc     1740

gtggtgtcta ccggcacaag cttcagctct agctctcctg gactggctag tgccggtgcc     1800

gctgagggaa aacaaggcgc cgaatctgat caggccgagc ctatcatctg tagcagcgga     1860

gcagaagccc ctgccaatag cctgcctagc aaggtgccaa ccacactgat gcccgtgaac     1920

acagtggccc tgaaggtgcc agctaatcct gcctccgtgt ccaccgtgcc ttctaagctg     1980

ccaaccagct ctaagccacc tggcgccgtg ccatctaacg ccctgacaaa tcctgctcca     2040

agcaagctgc ccatcaactc cacaagagcc ggcatggtgc cctctaaggt gcccacatct     2100

atggtgctga ccaaggtgtc cgccagcacc gtgccaacag atggcagctc cagaaacgag     2160

gaaacccctg ccgctcctac tcctgctggc gctacaggcg gatcttctgc ttggctggat     2220

agcagcagcg agaacagagg cctgggcagc gagctttcta aacctggcgt gctggcttcc     2280

caggtggaca gcccattttc cggctgcttt gaggacctgg ctatcagcgc ctctacaagc     2340

ctcggcatgg gaccttgtca cggccccgag gaaaacgagt acaagagcga gggcaccttc     2400

ggcatccacg tggccgagaa tcctagcatc caactgctgg aaggcaaccc cggacctcca     2460

gctgatccag atggcggacc aagacctcag gccgacagaa agttccaaga gcgcgaggtg     2520

ccctgccaca gaccttctcc a                                               2541


<210>  16
<211>  847
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion of LMP1 of Epstein Barr virus and IPS1 of Homo sapiens

<400>  16

Met Asp Leu Asp Leu Glu Arg Gly Pro Pro Gly Pro Arg Arg Pro Pro 
1               5                   10                  15      


Arg Gly Pro Pro Leu Ser Ser Ser Ile Gly Leu Ala Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Ala Leu Leu Phe Trp Leu Tyr Ile Ile Met Ser Asn Trp Thr 
        35                  40                  45              


Gly Gly Ala Leu Leu Val Leu Tyr Ala Phe Ala Leu Met Leu Val Ile 
    50                  55                  60                  


Ile Ile Leu Ile Ile Phe Ile Phe Arg Arg Asp Leu Leu Cys Pro Leu 
65                  70                  75                  80  


Gly Ala Leu Cys Leu Leu Leu Leu Met Ile Thr Leu Leu Leu Ile Ala 
                85                  90                  95      


Leu Trp Asn Leu His Gly Gln Ala Leu Tyr Leu Gly Ile Val Leu Phe 
            100                 105                 110         


Ile Phe Gly Cys Leu Leu Val Leu Gly Leu Trp Ile Tyr Leu Leu Glu 
        115                 120                 125             


Ile Leu Trp Arg Leu Gly Ala Thr Ile Trp Gln Leu Leu Ala Phe Phe 
    130                 135                 140                 


Leu Ala Phe Phe Leu Asp Ile Ile Leu Leu Ile Ile Ala Leu Tyr Leu 
145                 150                 155                 160 


Gln Gln Asn Trp Trp Thr Leu Leu Val Asp Leu Leu Trp Leu Leu Leu 
                165                 170                 175     


Phe Leu Ala Ile Leu Ile Trp Met Tyr Tyr His Gly Gln Arg His Ser 
            180                 185                 190         


Asp Glu His His His Asp Asp Ser Leu Pro His Pro Gln Gln Ala Thr 
        195                 200                 205             


Asp Asp Ser Ser Asn Gln Ser Asp Ser Asn Ser Asn Glu Gly Arg His 
    210                 215                 220                 


Leu Leu Leu Val Ser Gly Ala Gly Asp Gly Pro Pro Leu Cys Ser Gln 
225                 230                 235                 240 


Asn Leu Gly Ala Pro Gly Gly Gly Pro Asn Asn Gly Pro Gln Asp Pro 
                245                 250                 255     


Asp Asn Thr Asp Asp Asn Gly Pro Gln Asp Pro Asp Asn Thr Asp Asp 
            260                 265                 270         


Asn Gly Pro His Asp Pro Leu Pro Gln Asp Pro Asp Asn Thr Asp Asp 
        275                 280                 285             


Asn Gly Pro Gln Asp Pro Asp Asn Thr Asp Asp Asn Gly Pro His Asp 
    290                 295                 300                 


Pro Leu Pro His Asn Pro Ser Asp Ser Ala Gly Asn Asp Gly Gly Pro 
305                 310                 315                 320 


Pro Gln Leu Thr Glu Glu Val Glu Asn Lys Gly Gly Asp Gln Gly Pro 
                325                 330                 335     


Pro Leu Met Thr Asp Gly Gly Gly Gly His Ser His Asp Ser Gly His 
            340                 345                 350         


Asp Gly Ile Asp Pro His Leu Pro Thr Leu Leu Leu Gly Thr Ser Gly 
        355                 360                 365             


Ser Gly Gly Asp Asp Asp Asp Pro His Gly Pro Val Gln Leu Ser Tyr 
    370                 375                 380                 


Tyr Asp Pro Phe Ala Glu Asp Lys Thr Tyr Lys Tyr Ile Cys Arg Asn 
385                 390                 395                 400 


Phe Ser Asn Phe Cys Asn Val Asp Val Val Glu Ile Leu Pro Tyr Leu 
                405                 410                 415     


Pro Cys Leu Thr Ala Arg Asp Gln Asp Arg Leu Arg Ala Thr Cys Thr 
            420                 425                 430         


Leu Ser Gly Asn Arg Asp Thr Leu Trp His Leu Phe Asn Thr Leu Gln 
        435                 440                 445             


Arg Arg Pro Gly Trp Val Glu Tyr Phe Ile Ala Ala Leu Arg Gly Cys 
    450                 455                 460                 


Glu Leu Val Asp Leu Ala Asp Glu Val Ala Ser Val Tyr Gln Ser Tyr 
465                 470                 475                 480 


Gln Pro Arg Thr Ser Asp Arg Gly Glu Asn Ser Glu Gln Ala Leu Gln 
                485                 490                 495     


Thr Leu Ser Pro Arg Ala Ile Pro Arg Asn Pro Asp Gly Gly Pro Leu 
            500                 505                 510         


Glu Ser Ser Ser Asp Leu Ala Ala Leu Ser Pro Leu Thr Ser Ser Gly 
        515                 520                 525             


His Gln Glu Gln Asp Thr Glu Leu Gly Ser Thr His Thr Ala Gly Ala 
    530                 535                 540                 


Thr Ser Ser Leu Thr Pro Ser Arg Gly Pro Val Ser Pro Ser Val Ser 
545                 550                 555                 560 


Phe Gln Pro Leu Ala Arg Ser Thr Pro Arg Ala Ser Arg Leu Pro Gly 
                565                 570                 575     


Pro Thr Gly Ser Val Val Ser Thr Gly Thr Ser Phe Ser Ser Ser Ser 
            580                 585                 590         


Pro Gly Leu Ala Ser Ala Gly Ala Ala Glu Gly Lys Gln Gly Ala Glu 
        595                 600                 605             


Ser Asp Gln Ala Glu Pro Ile Ile Cys Ser Ser Gly Ala Glu Ala Pro 
    610                 615                 620                 


Ala Asn Ser Leu Pro Ser Lys Val Pro Thr Thr Leu Met Pro Val Asn 
625                 630                 635                 640 


Thr Val Ala Leu Lys Val Pro Ala Asn Pro Ala Ser Val Ser Thr Val 
                645                 650                 655     


Pro Ser Lys Leu Pro Thr Ser Ser Lys Pro Pro Gly Ala Val Pro Ser 
            660                 665                 670         


Asn Ala Leu Thr Asn Pro Ala Pro Ser Lys Leu Pro Ile Asn Ser Thr 
        675                 680                 685             


Arg Ala Gly Met Val Pro Ser Lys Val Pro Thr Ser Met Val Leu Thr 
    690                 695                 700                 


Lys Val Ser Ala Ser Thr Val Pro Thr Asp Gly Ser Ser Arg Asn Glu 
705                 710                 715                 720 


Glu Thr Pro Ala Ala Pro Thr Pro Ala Gly Ala Thr Gly Gly Ser Ser 
                725                 730                 735     


Ala Trp Leu Asp Ser Ser Ser Glu Asn Arg Gly Leu Gly Ser Glu Leu 
            740                 745                 750         


Ser Lys Pro Gly Val Leu Ala Ser Gln Val Asp Ser Pro Phe Ser Gly 
        755                 760                 765             


Cys Phe Glu Asp Leu Ala Ile Ser Ala Ser Thr Ser Leu Gly Met Gly 
    770                 775                 780                 


Pro Cys His Gly Pro Glu Glu Asn Glu Tyr Lys Ser Glu Gly Thr Phe 
785                 790                 795                 800 


Gly Ile His Val Ala Glu Asn Pro Ser Ile Gln Leu Leu Glu Gly Asn 
                805                 810                 815     


Pro Gly Pro Pro Ala Asp Pro Asp Gly Gly Pro Arg Pro Gln Ala Asp 
            820                 825                 830         


Arg Lys Phe Gln Glu Arg Glu Val Pro Cys His Arg Pro Ser Pro 
        835                 840                 845         


<210>  17
<211>  2697
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion of LMP1 of Epstein Barr virus and IPS1 of Homo sapiens

<400>  17
atggatctgg acctggaaag aggacctcct ggacctagac ggcctcctag aggaccacct       60

ctgagcagct ctattggact ggccctgctg ctgcttctgc tggctctgct gttctggctg      120

tacatcatca tgagcaactg gaccggcgga gcactgctgg tgctgtatgc ctttgctctg      180

atgctggtca tcatcatcct gatcatcttc atcttccggc gggacctgct gtgtcctctg      240

ggagcacttt gtctgttgct gctgatgatc accctcctgc tgatcgccct gtggaacctg      300

catggacagg ccctgtatct gggaatcgtg ctgttcatct tcggctgcct gctggttctc      360

ggcctgtgga tctacctgct ggaaatcctt tggagactgg gcgccaccat ctggcagctg      420

ctggcctttt tcctggcctt ctttctggat atcatcctcc tcatcattgc cctgtacctg      480

cagcagaact ggtggaccct gctggtggat ctgctttggc tgctgctctt tctggccatc      540

ctgatttgga tgtactacca cggccagcgg cacagcgacg aacaccacca tgatgacagc      600

ctgcctcatc ctcagcaggc caccgacgat agcagcaacc agagcgacag caacagcaac      660

gagggcagac atctgctgct ggtgtctggt gctggcgacg gacctcctct gtgttctcaa      720

aatcttggcg cccctggcgg cggaccaaac aatggacctc aggaccccga caacaccgac      780

gacaatggcc ctcaagatcc tgataatacc gatgacaacg gcccacacga ccctctgcct      840

caagacccag ataacacaga cgataacggt ccacaagatc cggacaatac tgacgataat      900

ggaccccacg atccactgcc tcacaaccct agcgatagcg ccggaaatga tggcggacct      960

ccacagctga ccgaggaagt ggaaaacaaa ggcggagatc agggccctcc tctgatgacc     1020

gatggcggag gtggacactc tcacgattct ggccacgacg gcatcgaccc tcatctgcct     1080

acactgctgc tcggcacatc tggctctggc ggcgacgatg atgatcctca tggacctgtg     1140

cagctgagct actacgaccc ttctccaaga cactgcccag tggaaagaga gcagttcaag     1200

agggacgccc agcctagacc tggcggagat cctgatgctc cacctggacc aaatggcgag     1260

ctgctgcaga tcagccctaa tgaggccgtg cacatcggct tcaccggcga gtctaagtac     1320

gagaacgagg aacccggcca ctgtcctggc atgggccttt ctacatctgc ctctatcgcc     1380

ctggacgagt tctgcggcag ctttccatct gatgtgcagt ctgccctcgt gggccctaag     1440

tctctggaat ctggcctggg cagaaacgag agcagctccg atctgtgggc tagctctggt     1500

ggaacagctg gcgctcctac accagccgct cctaccgaag agaatagaag cagcggcgac     1560

acccctgtga caagcgcctc tgtgaaaacc ctggtcatga gcaccccagt gaagtcccca     1620

gtgatgggcg ccagaacctc caacattccc ctgaagtctc ccgctcctaa cacactggcc     1680

aactctccag tggctggccc tcctaagtct agcacccctc tgaaaagccc cgtgacctct     1740

gtgtctgccc ctaacgctcc tgtgaaactg gccgtgacca acgtgcccat gctgaccaca     1800

cctgtgaaat ccccactgag caatgcccct gccgaggccg gaagctcttg tatcattccc     1860

gaggctcagg atagcgaggc tggccaaaaa ggcgaagctg caggcgcttc tgctctgggc     1920

cctagctcta gctcttttag caccggcacc agcgtggtgt ctggcacacc aggacctctg     1980

agaagcgcca gacctacctc tagagccctg cctcagttta gcgtgtcccc tagtgtgcct     2040

ggcagaagcc ctacactgtc tagtacagcc ggcgctacac acaccagcgg actggaaaca     2100

gaccaagaac agcatggcag cagcaccctg ccttctctgg ctgcccttga ttctagcagc     2160

gaactgccag gcggcgaccc caatagacct atcgctagac ctagcctgac acagctggcc     2220

caagagagca atgagggccc ttctgagcct gctcagaccg aacaggtgcc aatgccttac     2280

agccccgaga aagagcggtg cagcaactac cctatcagcc atgccgctgc tcccacacct     2340

cctggtccaa gagaagctcc tctgagccct cctgagctgc ccgatcctcc aagagatagc     2400

accagacctc agtactccca gtacgtgtcc gccgtggaag atgccctgga tgtgctggaa     2460

tgtggcagac tggccgccat cttctacgaa gtgtggggcc ctagaaggca gctgaccaac     2520

tttctgcact ggctgaccga cagaaacggc agcctgacat gtaccgccag actgagagat     2580

caggaccggg ccacactgtg ccctctgtat cctctgatcg aggtggtgga cgtgaactgc     2640

ttcaacagct tcaaccggtg catctacaag tacaccaagg acgaggcttt ccctatg        2697


<210>  18
<211>  899
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion of LMP1 of Epstein Barr virus and IPS1 of Homo sapiens

<400>  18

Met Asp Leu Asp Leu Glu Arg Gly Pro Pro Gly Pro Arg Arg Pro Pro 
1               5                   10                  15      


Arg Gly Pro Pro Leu Ser Ser Ser Ile Gly Leu Ala Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Ala Leu Leu Phe Trp Leu Tyr Ile Ile Met Ser Asn Trp Thr 
        35                  40                  45              


Gly Gly Ala Leu Leu Val Leu Tyr Ala Phe Ala Leu Met Leu Val Ile 
    50                  55                  60                  


Ile Ile Leu Ile Ile Phe Ile Phe Arg Arg Asp Leu Leu Cys Pro Leu 
65                  70                  75                  80  


Gly Ala Leu Cys Leu Leu Leu Leu Met Ile Thr Leu Leu Leu Ile Ala 
                85                  90                  95      


Leu Trp Asn Leu His Gly Gln Ala Leu Tyr Leu Gly Ile Val Leu Phe 
            100                 105                 110         


Ile Phe Gly Cys Leu Leu Val Leu Gly Leu Trp Ile Tyr Leu Leu Glu 
        115                 120                 125             


Ile Leu Trp Arg Leu Gly Ala Thr Ile Trp Gln Leu Leu Ala Phe Phe 
    130                 135                 140                 


Leu Ala Phe Phe Leu Asp Ile Ile Leu Leu Ile Ile Ala Leu Tyr Leu 
145                 150                 155                 160 


Gln Gln Asn Trp Trp Thr Leu Leu Val Asp Leu Leu Trp Leu Leu Leu 
                165                 170                 175     


Phe Leu Ala Ile Leu Ile Trp Met Tyr Tyr His Gly Gln Arg His Ser 
            180                 185                 190         


Asp Glu His His His Asp Asp Ser Leu Pro His Pro Gln Gln Ala Thr 
        195                 200                 205             


Asp Asp Ser Ser Asn Gln Ser Asp Ser Asn Ser Asn Glu Gly Arg His 
    210                 215                 220                 


Leu Leu Leu Val Ser Gly Ala Gly Asp Gly Pro Pro Leu Cys Ser Gln 
225                 230                 235                 240 


Asn Leu Gly Ala Pro Gly Gly Gly Pro Asn Asn Gly Pro Gln Asp Pro 
                245                 250                 255     


Asp Asn Thr Asp Asp Asn Gly Pro Gln Asp Pro Asp Asn Thr Asp Asp 
            260                 265                 270         


Asn Gly Pro His Asp Pro Leu Pro Gln Asp Pro Asp Asn Thr Asp Asp 
        275                 280                 285             


Asn Gly Pro Gln Asp Pro Asp Asn Thr Asp Asp Asn Gly Pro His Asp 
    290                 295                 300                 


Pro Leu Pro His Asn Pro Ser Asp Ser Ala Gly Asn Asp Gly Gly Pro 
305                 310                 315                 320 


Pro Gln Leu Thr Glu Glu Val Glu Asn Lys Gly Gly Asp Gln Gly Pro 
                325                 330                 335     


Pro Leu Met Thr Asp Gly Gly Gly Gly His Ser His Asp Ser Gly His 
            340                 345                 350         


Asp Gly Ile Asp Pro His Leu Pro Thr Leu Leu Leu Gly Thr Ser Gly 
        355                 360                 365             


Ser Gly Gly Asp Asp Asp Asp Pro His Gly Pro Val Gln Leu Ser Tyr 
    370                 375                 380                 


Tyr Asp Pro Ser Pro Arg His Cys Pro Val Glu Arg Glu Gln Phe Lys 
385                 390                 395                 400 


Arg Asp Ala Gln Pro Arg Pro Gly Gly Asp Pro Asp Ala Pro Pro Gly 
                405                 410                 415     


Pro Asn Gly Glu Leu Leu Gln Ile Ser Pro Asn Glu Ala Val His Ile 
            420                 425                 430         


Gly Phe Thr Gly Glu Ser Lys Tyr Glu Asn Glu Glu Pro Gly His Cys 
        435                 440                 445             


Pro Gly Met Gly Leu Ser Thr Ser Ala Ser Ile Ala Leu Asp Glu Phe 
    450                 455                 460                 


Cys Gly Ser Phe Pro Ser Asp Val Gln Ser Ala Leu Val Gly Pro Lys 
465                 470                 475                 480 


Ser Leu Glu Ser Gly Leu Gly Arg Asn Glu Ser Ser Ser Asp Leu Trp 
                485                 490                 495     


Ala Ser Ser Gly Gly Thr Ala Gly Ala Pro Thr Pro Ala Ala Pro Thr 
            500                 505                 510         


Glu Glu Asn Arg Ser Ser Gly Asp Thr Pro Val Thr Ser Ala Ser Val 
        515                 520                 525             


Lys Thr Leu Val Met Ser Thr Pro Val Lys Ser Pro Val Met Gly Ala 
    530                 535                 540                 


Arg Thr Ser Asn Ile Pro Leu Lys Ser Pro Ala Pro Asn Thr Leu Ala 
545                 550                 555                 560 


Asn Ser Pro Val Ala Gly Pro Pro Lys Ser Ser Thr Pro Leu Lys Ser 
                565                 570                 575     


Pro Val Thr Ser Val Ser Ala Pro Asn Ala Pro Val Lys Leu Ala Val 
            580                 585                 590         


Thr Asn Val Pro Met Leu Thr Thr Pro Val Lys Ser Pro Leu Ser Asn 
        595                 600                 605             


Ala Pro Ala Glu Ala Gly Ser Ser Cys Ile Ile Pro Glu Ala Gln Asp 
    610                 615                 620                 


Ser Glu Ala Gly Gln Lys Gly Glu Ala Ala Gly Ala Ser Ala Leu Gly 
625                 630                 635                 640 


Pro Ser Ser Ser Ser Phe Ser Thr Gly Thr Ser Val Val Ser Gly Thr 
                645                 650                 655     


Pro Gly Pro Leu Arg Ser Ala Arg Pro Thr Ser Arg Ala Leu Pro Gln 
            660                 665                 670         


Phe Ser Val Ser Pro Ser Val Pro Gly Arg Ser Pro Thr Leu Ser Ser 
        675                 680                 685             


Thr Ala Gly Ala Thr His Thr Ser Gly Leu Glu Thr Asp Gln Glu Gln 
    690                 695                 700                 


His Gly Ser Ser Thr Leu Pro Ser Leu Ala Ala Leu Asp Ser Ser Ser 
705                 710                 715                 720 


Glu Leu Pro Gly Gly Asp Pro Asn Arg Pro Ile Ala Arg Pro Ser Leu 
                725                 730                 735     


Thr Gln Leu Ala Gln Glu Ser Asn Glu Gly Pro Ser Glu Pro Ala Gln 
            740                 745                 750         


Thr Glu Gln Val Pro Met Pro Tyr Ser Pro Glu Lys Glu Arg Cys Ser 
        755                 760                 765             


Asn Tyr Pro Ile Ser His Ala Ala Ala Pro Thr Pro Pro Gly Pro Arg 
    770                 775                 780                 


Glu Ala Pro Leu Ser Pro Pro Glu Leu Pro Asp Pro Pro Arg Asp Ser 
785                 790                 795                 800 


Thr Arg Pro Gln Tyr Ser Gln Tyr Val Ser Ala Val Glu Asp Ala Leu 
                805                 810                 815     


Asp Val Leu Glu Cys Gly Arg Leu Ala Ala Ile Phe Tyr Glu Val Trp 
            820                 825                 830         


Gly Pro Arg Arg Gln Leu Thr Asn Phe Leu His Trp Leu Thr Asp Arg 
        835                 840                 845             


Asn Gly Ser Leu Thr Cys Thr Ala Arg Leu Arg Asp Gln Asp Arg Ala 
    850                 855                 860                 


Thr Leu Cys Pro Leu Tyr Pro Leu Ile Glu Val Val Asp Val Asn Cys 
865                 870                 875                 880 


Phe Asn Ser Phe Asn Arg Cys Ile Tyr Lys Tyr Thr Lys Asp Glu Ala 
                885                 890                 895     


Phe Pro Met 
            


<210>  19
<211>  2694
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion of LMP1 of Epstein Barr virus and IPS1 of Homo sapiens

<400>  19
atggatctgg atctcgaaag aggacctcct ggacctagac ggcctcctag aggaccacct       60

ctgagcagct ctattggact ggccctgctg ctgcttctgc tggctctgct gttctggctg      120

tacatcatca tgagcaactg gaccggcgga gcactgctgg tgctgtatgc ctttgctctg      180

atgctggtca tcatcatcct gatcatcttc atcttccggc gggacctgct gtgtcctctg      240

ggagcacttt gtctgttgct gctgatgatc accctcctgc tgatcgccct gtggaacctg      300

catggacagg ccctgtatct gggcatcgtg ctgttcatct tcggctgcct gctggttctc      360

ggcctgtgga tctacctgct ggaaatcctt tggagactgg gcgccaccat ctggcagctg      420

ctggcctttt tcctggcctt ctttctggat atcatcctcc tcatcattgc cctgtacctg      480

cagcagaact ggtggaccct gctggtggat ctgctttggc tgctgctctt tctggccatc      540

ctgatttgga tgtactacca cggccagcgg cctttcgccg aggacaagac ctacaagtac      600

atctgccgga acttcagcaa cttctgcaac gtggacgtgg tggaaattct gccctacctg      660

ccttgcctga ccgccagaga tcaggacaga ctgagagcca catgtaccct gagcggcaac      720

agagacacac tgtggcacct gttcaacacc ctgcagagaa ggcctggctg ggtcgagtac      780

tttatcgccg ctctgagagg ctgcgagctg gtcgatctgg ctgatgaagt ggccagcgtg      840

taccagagct accagcctag aaccagcgac cggcctcctg atcctctcga acctccatct      900

ctgcccgccg aaagacctgg acctcctaca ccagctgccg ctcacagcat cccttacaac      960

agctgcagag agaaagaacc tagctacccc atgcctgtgc aagagacaca ggccccagaa     1020

agccctggcg agaatagcga acaggctctg cagacactga gccccagagc cattcctaga     1080

aaccctgatg gcggccctct ggaaagctct agtgatctgg ccgctctgtc ccctctgaca     1140

agctctggac accaagagca ggataccgag ctgggcagca cacatacagc cggcgctaca     1200

agcagcctga caccttctag aggccccgtg tctcccagcg tgtcatttca gcctctggcc     1260

aggtctaccc ctagggcttc tagactgcct ggaccaacag gcagcgtggt gtctaccggc     1320

acaagcttca gctctagctc tcctggactg gctagtgccg gtgccgctga gggaaaacaa     1380

ggcgccgaat ctgatcaggc cgagcctatc atctgtagca gcggagcaga agcccctgcc     1440

aatagcctgc ctagcaaggt gccaaccaca ctgatgcccg tgaacacagt ggccctgaag     1500

gtgccagcta atcctgcctc cgtgtccacc gtgccttcta agctgccaac cagctctaag     1560

ccacctggcg ccgtgccatc taacgccctg acaaatcctg ctccaagcaa gctgcccatc     1620

aactccacaa gagccggcat ggtgccctct aaggtgccca catctatggt gctgaccaag     1680

gtgtccgcca gcaccgtgcc aacagatggc agctccagaa acgaggaaac ccctgccgct     1740

cctactcctg ctggcgctac aggcggatct tctgcttggc tggatagcag cagcgagaac     1800

agaggcctgg gcagcgagct ttctaaacct ggcgtgctgg cttcccaggt ggacagccca     1860

ttttccggct gctttgagga cctggctatc agcgcctcta caagcctcgg catgggacct     1920

tgtcacggcc ccgaggaaaa cgagtacaag agcgagggca ccttcggcat ccacgtggcc     1980

gagaatccta gcatccaact gctggaaggc aaccccggac ctccagctga tccagatggc     2040

ggaccaagac ctcaggccga cagaaagttc caagagcgcg aggtgccctg ccacagacct     2100

tctccacaca gcgacgaaca ccaccatgat gacagcctgc ctcatcctca gcaggccacc     2160

gacgatagca gcaaccagag cgacagcaac agcaacgagg gcagacatct gctgctggtg     2220

tctggtgctg gcgacggacc tcctctgtgt tctcaaaatc ttggcgcccc tggcggcgga     2280

ccaaacaatg gacctcagga ccccgacaac accgacgaca atggccctca agatcctgat     2340

aataccgatg acaacggccc acacgaccct ctgcctcaag acccagataa cacagacgat     2400

aacggtccac aagatccgga caatactgac gataatggac cccacgatcc actgcctcac     2460

aaccctagcg atagcgccgg aaatgatggc ggacctccac agctgaccga ggaagtggaa     2520

aacaaaggcg gagatcaggg ccctcctctg atgaccgatg gcggaggtgg acactctcac     2580

gattctggcc acgacggcat cgaccctcat ctgcctacac tgctgctcgg cacatctggc     2640

tctggcggcg acgatgatga tcctcatgga cctgtgcagc tgagctacta cgac           2694


<210>  20
<211>  898
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion of LMP1 of Epstein Barr virus and IPS1 of Homo sapieins

<400>  20

Met Asp Leu Asp Leu Glu Arg Gly Pro Pro Gly Pro Arg Arg Pro Pro 
1               5                   10                  15      


Arg Gly Pro Pro Leu Ser Ser Ser Ile Gly Leu Ala Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Ala Leu Leu Phe Trp Leu Tyr Ile Ile Met Ser Asn Trp Thr 
        35                  40                  45              


Gly Gly Ala Leu Leu Val Leu Tyr Ala Phe Ala Leu Met Leu Val Ile 
    50                  55                  60                  


Ile Ile Leu Ile Ile Phe Ile Phe Arg Arg Asp Leu Leu Cys Pro Leu 
65                  70                  75                  80  


Gly Ala Leu Cys Leu Leu Leu Leu Met Ile Thr Leu Leu Leu Ile Ala 
                85                  90                  95      


Leu Trp Asn Leu His Gly Gln Ala Leu Tyr Leu Gly Ile Val Leu Phe 
            100                 105                 110         


Ile Phe Gly Cys Leu Leu Val Leu Gly Leu Trp Ile Tyr Leu Leu Glu 
        115                 120                 125             


Ile Leu Trp Arg Leu Gly Ala Thr Ile Trp Gln Leu Leu Ala Phe Phe 
    130                 135                 140                 


Leu Ala Phe Phe Leu Asp Ile Ile Leu Leu Ile Ile Ala Leu Tyr Leu 
145                 150                 155                 160 


Gln Gln Asn Trp Trp Thr Leu Leu Val Asp Leu Leu Trp Leu Leu Leu 
                165                 170                 175     


Phe Leu Ala Ile Leu Ile Trp Met Tyr Tyr His Gly Gln Arg Pro Phe 
            180                 185                 190         


Ala Glu Asp Lys Thr Tyr Lys Tyr Ile Cys Arg Asn Phe Ser Asn Phe 
        195                 200                 205             


Cys Asn Val Asp Val Val Glu Ile Leu Pro Tyr Leu Pro Cys Leu Thr 
    210                 215                 220                 


Ala Arg Asp Gln Asp Arg Leu Arg Ala Thr Cys Thr Leu Ser Gly Asn 
225                 230                 235                 240 


Arg Asp Thr Leu Trp His Leu Phe Asn Thr Leu Gln Arg Arg Pro Gly 
                245                 250                 255     


Trp Val Glu Tyr Phe Ile Ala Ala Leu Arg Gly Cys Glu Leu Val Asp 
            260                 265                 270         


Leu Ala Asp Glu Val Ala Ser Val Tyr Gln Ser Tyr Gln Pro Arg Thr 
        275                 280                 285             


Ser Asp Arg Pro Pro Asp Pro Leu Glu Pro Pro Ser Leu Pro Ala Glu 
    290                 295                 300                 


Arg Pro Gly Pro Pro Thr Pro Ala Ala Ala His Ser Ile Pro Tyr Asn 
305                 310                 315                 320 


Ser Cys Arg Glu Lys Glu Pro Ser Tyr Pro Met Pro Val Gln Glu Thr 
                325                 330                 335     


Gln Ala Pro Glu Ser Pro Gly Glu Asn Ser Glu Gln Ala Leu Gln Thr 
            340                 345                 350         


Leu Ser Pro Arg Ala Ile Pro Arg Asn Pro Asp Gly Gly Pro Leu Glu 
        355                 360                 365             


Ser Ser Ser Asp Leu Ala Ala Leu Ser Pro Leu Thr Ser Ser Gly His 
    370                 375                 380                 


Gln Glu Gln Asp Thr Glu Leu Gly Ser Thr His Thr Ala Gly Ala Thr 
385                 390                 395                 400 


Ser Ser Leu Thr Pro Ser Arg Gly Pro Val Ser Pro Ser Val Ser Phe 
                405                 410                 415     


Gln Pro Leu Ala Arg Ser Thr Pro Arg Ala Ser Arg Leu Pro Gly Pro 
            420                 425                 430         


Thr Gly Ser Val Val Ser Thr Gly Thr Ser Phe Ser Ser Ser Ser Pro 
        435                 440                 445             


Gly Leu Ala Ser Ala Gly Ala Ala Glu Gly Lys Gln Gly Ala Glu Ser 
    450                 455                 460                 


Asp Gln Ala Glu Pro Ile Ile Cys Ser Ser Gly Ala Glu Ala Pro Ala 
465                 470                 475                 480 


Asn Ser Leu Pro Ser Lys Val Pro Thr Thr Leu Met Pro Val Asn Thr 
                485                 490                 495     


Val Ala Leu Lys Val Pro Ala Asn Pro Ala Ser Val Ser Thr Val Pro 
            500                 505                 510         


Ser Lys Leu Pro Thr Ser Ser Lys Pro Pro Gly Ala Val Pro Ser Asn 
        515                 520                 525             


Ala Leu Thr Asn Pro Ala Pro Ser Lys Leu Pro Ile Asn Ser Thr Arg 
    530                 535                 540                 


Ala Gly Met Val Pro Ser Lys Val Pro Thr Ser Met Val Leu Thr Lys 
545                 550                 555                 560 


Val Ser Ala Ser Thr Val Pro Thr Asp Gly Ser Ser Arg Asn Glu Glu 
                565                 570                 575     


Thr Pro Ala Ala Pro Thr Pro Ala Gly Ala Thr Gly Gly Ser Ser Ala 
            580                 585                 590         


Trp Leu Asp Ser Ser Ser Glu Asn Arg Gly Leu Gly Ser Glu Leu Ser 
        595                 600                 605             


Lys Pro Gly Val Leu Ala Ser Gln Val Asp Ser Pro Phe Ser Gly Cys 
    610                 615                 620                 


Phe Glu Asp Leu Ala Ile Ser Ala Ser Thr Ser Leu Gly Met Gly Pro 
625                 630                 635                 640 


Cys His Gly Pro Glu Glu Asn Glu Tyr Lys Ser Glu Gly Thr Phe Gly 
                645                 650                 655     


Ile His Val Ala Glu Asn Pro Ser Ile Gln Leu Leu Glu Gly Asn Pro 
            660                 665                 670         


Gly Pro Pro Ala Asp Pro Asp Gly Gly Pro Arg Pro Gln Ala Asp Arg 
        675                 680                 685             


Lys Phe Gln Glu Arg Glu Val Pro Cys His Arg Pro Ser Pro His Ser 
    690                 695                 700                 


Asp Glu His His His Asp Asp Ser Leu Pro His Pro Gln Gln Ala Thr 
705                 710                 715                 720 


Asp Asp Ser Ser Asn Gln Ser Asp Ser Asn Ser Asn Glu Gly Arg His 
                725                 730                 735     


Leu Leu Leu Val Ser Gly Ala Gly Asp Gly Pro Pro Leu Cys Ser Gln 
            740                 745                 750         


Asn Leu Gly Ala Pro Gly Gly Gly Pro Asn Asn Gly Pro Gln Asp Pro 
        755                 760                 765             


Asp Asn Thr Asp Asp Asn Gly Pro Gln Asp Pro Asp Asn Thr Asp Asp 
    770                 775                 780                 


Asn Gly Pro His Asp Pro Leu Pro Gln Asp Pro Asp Asn Thr Asp Asp 
785                 790                 795                 800 


Asn Gly Pro Gln Asp Pro Asp Asn Thr Asp Asp Asn Gly Pro His Asp 
                805                 810                 815     


Pro Leu Pro His Asn Pro Ser Asp Ser Ala Gly Asn Asp Gly Gly Pro 
            820                 825                 830         


Pro Gln Leu Thr Glu Glu Val Glu Asn Lys Gly Gly Asp Gln Gly Pro 
        835                 840                 845             


Pro Leu Met Thr Asp Gly Gly Gly Gly His Ser His Asp Ser Gly His 
    850                 855                 860                 


Asp Gly Ile Asp Pro His Leu Pro Thr Leu Leu Leu Gly Thr Ser Gly 
865                 870                 875                 880 


Ser Gly Gly Asp Asp Asp Asp Pro His Gly Pro Val Gln Leu Ser Tyr 
                885                 890                 895     


Tyr Asp 
        


<210>  21
<211>  2541
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion of LMP1 of Epstein Barr virus and IPS1 of Homo sapiens

<400>  21
atggatctgg atctcgaaag aggacctcct ggacctagac ggcctcctag aggaccacct       60

ctgagcagct ctattggact ggccctgctg ctgcttctgc tggctctgct gttctggctg      120

tacatcatca tgagcaactg gaccggcgga gcactgctgg tgctgtatgc ctttgctctg      180

atgctggtca tcatcatcct gatcatcttc atcttccggc gggacctgct gtgtcctctg      240

ggagcacttt gtctgttgct gctgatgatc accctcctgc tgatcgccct gtggaacctg      300

catggacagg ccctgtatct gggcatcgtg ctgttcatct tcggctgcct gctggttctc      360

ggcctgtgga tctacctgct ggaaatcctt tggagactgg gcgccaccat ctggcagctg      420

ctggcctttt tcctggcctt ctttctggat atcatcctcc tcatcattgc cctgtacctg      480

cagcagaact ggtggaccct gctggtggat ctgctttggc tgctgctctt tctggccatc      540

ctgatttgga tgtactacca cggccagcgg cctttcgccg aggacaagac ctacaagtac      600

atctgccgga acttcagcaa cttctgcaac gtggacgtgg tggaaattct gccctacctg      660

ccttgcctga ccgccagaga tcaggacaga ctgagagcca catgtaccct gagcggcaac      720

agagacacac tgtggcacct gttcaacacc ctgcagagaa ggcctggctg ggtcgagtac      780

tttatcgccg ctctgagagg ctgcgagctg gtcgatctgg ctgatgaagt ggccagcgtg      840

taccagagct accagcctag aaccagcgac cggggcgaga atagcgaaca ggctctgcag      900

acactgagcc ccagagccat tcctagaaac cctgatggcg gccctctgga aagctctagt      960

gatctggccg ctctgtcccc tctgacaagc tctggacacc aagagcagga taccgagctg     1020

ggcagcacac atacagccgg cgctacaagc agcctgacac cttctagagg ccccgtgtct     1080

cccagcgtgt catttcagcc tctggccagg tctaccccta gggcttctag actgcctgga     1140

ccaacaggca gcgtggtgtc taccggcaca agcttcagct ctagctctcc tggactggct     1200

agtgccggtg ccgctgaggg aaaacaaggc gccgaatctg atcaggccga gcctatcatc     1260

tgtagcagcg gagcagaagc ccctgccaat agcctgccta gcaaggtgcc aaccacactg     1320

atgcccgtga acacagtggc cctgaaggtg ccagctaatc ctgcctccgt gtccaccgtg     1380

ccttctaagc tgccaaccag ctctaagcca cctggcgccg tgccatctaa cgccctgaca     1440

aatcctgctc caagcaagct gcccatcaac tccacaagag ccggcatggt gccctctaag     1500

gtgcccacat ctatggtgct gaccaaggtg tccgccagca ccgtgccaac agatggcagc     1560

tccagaaacg aggaaacccc tgccgctcct actcctgctg gcgctacagg cggatcttct     1620

gcttggctgg atagcagcag cgagaacaga ggcctgggca gcgagctttc taaacctggc     1680

gtgctggctt cccaggtgga cagcccattt tccggctgct ttgaggacct ggctatcagc     1740

gcctctacaa gcctcggcat gggaccttgt cacggccccg aggaaaacga gtacaagagc     1800

gagggcacct tcggcatcca cgtggccgag aatcctagca tccaactgct ggaaggcaac     1860

cccggacctc cagctgatcc agatggcgga ccaagacctc aggccgacag aaagttccaa     1920

gagcgcgagg tgccctgcca cagaccttct ccacacagcg acgaacacca ccatgatgac     1980

agcctgcctc atcctcagca ggccaccgac gatagcagca accagagcga cagcaacagc     2040

aacgagggca gacatctgct gctggtgtct ggtgctggcg acggacctcc tctgtgttct     2100

caaaatcttg gcgcccctgg cggcggacca aacaatggac ctcaggaccc cgacaacacc     2160

gacgacaatg gccctcaaga tcctgataat accgatgaca acggcccaca cgaccctctg     2220

cctcaagacc cagataacac agacgataac ggtccacaag atccggacaa tactgacgat     2280

aatggacccc acgatccact gcctcacaac cctagcgata gcgccggaaa tgatggcgga     2340

cctccacagc tgaccgagga agtggaaaac aaaggcggag atcagggccc tcctctgatg     2400

accgatggcg gaggtggaca ctctcacgat tctggccacg acggcatcga ccctcatctg     2460

cctacactgc tgctcggcac atctggctct ggcggcgacg atgatgatcc tcatggacct     2520

gtgcagctga gctactacga c                                               2541


<210>  22
<211>  847
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion of LMP1 of Epstein Barr virus and IPS1 of Homo sapiens

<400>  22

Met Asp Leu Asp Leu Glu Arg Gly Pro Pro Gly Pro Arg Arg Pro Pro 
1               5                   10                  15      


Arg Gly Pro Pro Leu Ser Ser Ser Ile Gly Leu Ala Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Ala Leu Leu Phe Trp Leu Tyr Ile Ile Met Ser Asn Trp Thr 
        35                  40                  45              


Gly Gly Ala Leu Leu Val Leu Tyr Ala Phe Ala Leu Met Leu Val Ile 
    50                  55                  60                  


Ile Ile Leu Ile Ile Phe Ile Phe Arg Arg Asp Leu Leu Cys Pro Leu 
65                  70                  75                  80  


Gly Ala Leu Cys Leu Leu Leu Leu Met Ile Thr Leu Leu Leu Ile Ala 
                85                  90                  95      


Leu Trp Asn Leu His Gly Gln Ala Leu Tyr Leu Gly Ile Val Leu Phe 
            100                 105                 110         


Ile Phe Gly Cys Leu Leu Val Leu Gly Leu Trp Ile Tyr Leu Leu Glu 
        115                 120                 125             


Ile Leu Trp Arg Leu Gly Ala Thr Ile Trp Gln Leu Leu Ala Phe Phe 
    130                 135                 140                 


Leu Ala Phe Phe Leu Asp Ile Ile Leu Leu Ile Ile Ala Leu Tyr Leu 
145                 150                 155                 160 


Gln Gln Asn Trp Trp Thr Leu Leu Val Asp Leu Leu Trp Leu Leu Leu 
                165                 170                 175     


Phe Leu Ala Ile Leu Ile Trp Met Tyr Tyr His Gly Gln Arg Pro Phe 
            180                 185                 190         


Ala Glu Asp Lys Thr Tyr Lys Tyr Ile Cys Arg Asn Phe Ser Asn Phe 
        195                 200                 205             


Cys Asn Val Asp Val Val Glu Ile Leu Pro Tyr Leu Pro Cys Leu Thr 
    210                 215                 220                 


Ala Arg Asp Gln Asp Arg Leu Arg Ala Thr Cys Thr Leu Ser Gly Asn 
225                 230                 235                 240 


Arg Asp Thr Leu Trp His Leu Phe Asn Thr Leu Gln Arg Arg Pro Gly 
                245                 250                 255     


Trp Val Glu Tyr Phe Ile Ala Ala Leu Arg Gly Cys Glu Leu Val Asp 
            260                 265                 270         


Leu Ala Asp Glu Val Ala Ser Val Tyr Gln Ser Tyr Gln Pro Arg Thr 
        275                 280                 285             


Ser Asp Arg Gly Glu Asn Ser Glu Gln Ala Leu Gln Thr Leu Ser Pro 
    290                 295                 300                 


Arg Ala Ile Pro Arg Asn Pro Asp Gly Gly Pro Leu Glu Ser Ser Ser 
305                 310                 315                 320 


Asp Leu Ala Ala Leu Ser Pro Leu Thr Ser Ser Gly His Gln Glu Gln 
                325                 330                 335     


Asp Thr Glu Leu Gly Ser Thr His Thr Ala Gly Ala Thr Ser Ser Leu 
            340                 345                 350         


Thr Pro Ser Arg Gly Pro Val Ser Pro Ser Val Ser Phe Gln Pro Leu 
        355                 360                 365             


Ala Arg Ser Thr Pro Arg Ala Ser Arg Leu Pro Gly Pro Thr Gly Ser 
    370                 375                 380                 


Val Val Ser Thr Gly Thr Ser Phe Ser Ser Ser Ser Pro Gly Leu Ala 
385                 390                 395                 400 


Ser Ala Gly Ala Ala Glu Gly Lys Gln Gly Ala Glu Ser Asp Gln Ala 
                405                 410                 415     


Glu Pro Ile Ile Cys Ser Ser Gly Ala Glu Ala Pro Ala Asn Ser Leu 
            420                 425                 430         


Pro Ser Lys Val Pro Thr Thr Leu Met Pro Val Asn Thr Val Ala Leu 
        435                 440                 445             


Lys Val Pro Ala Asn Pro Ala Ser Val Ser Thr Val Pro Ser Lys Leu 
    450                 455                 460                 


Pro Thr Ser Ser Lys Pro Pro Gly Ala Val Pro Ser Asn Ala Leu Thr 
465                 470                 475                 480 


Asn Pro Ala Pro Ser Lys Leu Pro Ile Asn Ser Thr Arg Ala Gly Met 
                485                 490                 495     


Val Pro Ser Lys Val Pro Thr Ser Met Val Leu Thr Lys Val Ser Ala 
            500                 505                 510         


Ser Thr Val Pro Thr Asp Gly Ser Ser Arg Asn Glu Glu Thr Pro Ala 
        515                 520                 525             


Ala Pro Thr Pro Ala Gly Ala Thr Gly Gly Ser Ser Ala Trp Leu Asp 
    530                 535                 540                 


Ser Ser Ser Glu Asn Arg Gly Leu Gly Ser Glu Leu Ser Lys Pro Gly 
545                 550                 555                 560 


Val Leu Ala Ser Gln Val Asp Ser Pro Phe Ser Gly Cys Phe Glu Asp 
                565                 570                 575     


Leu Ala Ile Ser Ala Ser Thr Ser Leu Gly Met Gly Pro Cys His Gly 
            580                 585                 590         


Pro Glu Glu Asn Glu Tyr Lys Ser Glu Gly Thr Phe Gly Ile His Val 
        595                 600                 605             


Ala Glu Asn Pro Ser Ile Gln Leu Leu Glu Gly Asn Pro Gly Pro Pro 
    610                 615                 620                 


Ala Asp Pro Asp Gly Gly Pro Arg Pro Gln Ala Asp Arg Lys Phe Gln 
625                 630                 635                 640 


Glu Arg Glu Val Pro Cys His Arg Pro Ser Pro His Ser Asp Glu His 
                645                 650                 655     


His His Asp Asp Ser Leu Pro His Pro Gln Gln Ala Thr Asp Asp Ser 
            660                 665                 670         


Ser Asn Gln Ser Asp Ser Asn Ser Asn Glu Gly Arg His Leu Leu Leu 
        675                 680                 685             


Val Ser Gly Ala Gly Asp Gly Pro Pro Leu Cys Ser Gln Asn Leu Gly 
    690                 695                 700                 


Ala Pro Gly Gly Gly Pro Asn Asn Gly Pro Gln Asp Pro Asp Asn Thr 
705                 710                 715                 720 


Asp Asp Asn Gly Pro Gln Asp Pro Asp Asn Thr Asp Asp Asn Gly Pro 
                725                 730                 735     


His Asp Pro Leu Pro Gln Asp Pro Asp Asn Thr Asp Asp Asn Gly Pro 
            740                 745                 750         


Gln Asp Pro Asp Asn Thr Asp Asp Asn Gly Pro His Asp Pro Leu Pro 
        755                 760                 765             


His Asn Pro Ser Asp Ser Ala Gly Asn Asp Gly Gly Pro Pro Gln Leu 
    770                 775                 780                 


Thr Glu Glu Val Glu Asn Lys Gly Gly Asp Gln Gly Pro Pro Leu Met 
785                 790                 795                 800 


Thr Asp Gly Gly Gly Gly His Ser His Asp Ser Gly His Asp Gly Ile 
                805                 810                 815     


Asp Pro His Leu Pro Thr Leu Leu Leu Gly Thr Ser Gly Ser Gly Gly 
            820                 825                 830         


Asp Asp Asp Asp Pro His Gly Pro Val Gln Leu Ser Tyr Tyr Asp 
        835                 840                 845         


<210>  23
<211>  2697
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion of LMP1 of Epstein Barr virus and IPS1 of Homo sapiens

<400>  23
atggatctgg atctcgaaag aggacctcct ggacctagac ggcctcctag aggaccacct       60

ctgagcagct ctattggact ggccctgctg ctgcttctgc tggctctgct gttctggctg      120

tacatcatca tgagcaactg gaccggcgga gcactgctgg tgctgtatgc ctttgctctg      180

atgctggtca tcatcatcct gatcatcttc atcttccggc gggacctgct gtgtcctctg      240

ggagcacttt gtctgttgct gctgatgatc accctcctgc tgatcgccct gtggaacctg      300

catggacagg ccctgtatct gggcatcgtg ctgttcatct tcggctgcct gctggttctc      360

ggcctgtgga tctacctgct ggaaatcctt tggagactgg gcgccaccat ctggcagctg      420

ctggcctttt tcctggcctt ctttctggat atcatcctcc tcatcattgc cctgtacctg      480

cagcagaact ggtggaccct gctggtggat ctgctttggc tgctgctctt tctggccatc      540

ctgatttgga tgtactacca cggccagcgg ccttctccaa gacactgccc agtggaaaga      600

gagcagttca agagggacgc ccagcctaga cctggcggag atcctgatgc tccacctgga      660

ccaaatggcg agctgctgca gatcagccct aatgaggccg tgcacatcgg cttcaccggc      720

gagtctaagt acgagaacga ggaacccggc cactgtcctg gcatgggcct ttctacatct      780

gcctctatcg ccctggacga gttctgcggc agctttccat ctgatgtgca gtctgccctc      840

gtgggcccta agtctctgga atctggcctg ggcagaaacg agagcagctc cgatctgtgg      900

gctagctctg gtggaacagc tggcgctcct acaccagccg ctcctaccga agagaataga      960

agcagcggcg acacccctgt gacaagcgcc tctgtgaaaa ccctggtcat gagcacccca     1020

gtgaagtccc cagtgatggg cgccagaacc tccaacattc ccctgaagtc tcccgctcct     1080

aacacactgg ccaactctcc agtggctggc cctcctaagt ctagcacccc tctgaaaagc     1140

cccgtgacct ctgtgtctgc ccctaacgct cctgtgaaac tggccgtgac caacgtgccc     1200

atgctgacca cacctgtgaa atccccactg agcaatgccc ctgccgaggc cggaagctct     1260

tgtatcattc ccgaggctca ggatagcgag gctggccaaa aaggcgaagc tgcaggcgct     1320

tctgctctgg gccctagctc tagctctttt agcaccggca ccagcgtggt gtctggcaca     1380

ccaggacctc tgagaagcgc cagacctacc tctagagccc tgcctcagtt tagcgtgtcc     1440

cctagtgtgc ctggcagaag ccctacactg tctagtacag ccggcgctac acacaccagc     1500

ggactggaaa cagaccaaga acagcatggc agcagcaccc tgccttctct ggctgccctt     1560

gattctagca gcgaactgcc aggcggcgac cccaatagac ctatcgctag acctagcctg     1620

acacagctgg cccaagagag caatgagggc ccttctgagc ctgctcagac cgaacaggtg     1680

ccaatgcctt acagccccga gaaagagcgg tgcagcaact accctatcag ccatgccgct     1740

gctcccacac ctcctggtcc aagagaagct cctctgagcc ctcctgagct gcccgatcct     1800

ccaagagata gcaccagacc tcagtactcc cagtacgtgt ccgccgtgga agatgccctg     1860

gatgtgctgg aatgtggcag actggccgcc atcttctacg aagtgtgggg ccctagaagg     1920

cagctgacca actttctgca ctggctgacc gacagaaacg gcagcctgac atgtaccgcc     1980

agactgagag atcaggaccg ggccacactg tgccctctgt atcctctgat cgaggtggtg     2040

gacgtgaact gcttcaacag cttcaaccgg tgcatctaca agtacaccaa ggacgaggct     2100

ttccctatgc acagcgacga acaccaccat gatgacagcc tgcctcatcc tcagcaggcc     2160

accgacgata gcagcaacca gagcgacagc aacagcaacg agggcagaca tctgctgctg     2220

gtgtctggtg ctggcgacgg acctcctctg tgttctcaaa atcttggcgc ccctggcggc     2280

ggaccaaaca atggacctca ggaccccgac aacaccgacg acaatggccc tcaagatcct     2340

gataataccg atgacaacgg cccacacgac cctctgcctc aagacccaga taacacagac     2400

gataacggtc cacaagatcc ggacaatact gacgataatg gaccccacga tccactgcct     2460

cacaacccta gcgatagcgc cggaaatgat ggcggacctc cacagctgac cgaggaagtg     2520

gaaaacaaag gcggagatca gggccctcct ctgatgaccg atggcggagg tggacactct     2580

cacgattctg gccacgacgg catcgaccct catctgccta cactgctgct cggcacatct     2640

ggctctggcg gcgacgatga tgatcctcat ggacctgtgc agctgagcta ctacgac        2697


<210>  24
<211>  899
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion of LMP1 of Epstein Barr virus and IPS1 of Homo sapiens

<400>  24

Met Asp Leu Asp Leu Glu Arg Gly Pro Pro Gly Pro Arg Arg Pro Pro 
1               5                   10                  15      


Arg Gly Pro Pro Leu Ser Ser Ser Ile Gly Leu Ala Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Ala Leu Leu Phe Trp Leu Tyr Ile Ile Met Ser Asn Trp Thr 
        35                  40                  45              


Gly Gly Ala Leu Leu Val Leu Tyr Ala Phe Ala Leu Met Leu Val Ile 
    50                  55                  60                  


Ile Ile Leu Ile Ile Phe Ile Phe Arg Arg Asp Leu Leu Cys Pro Leu 
65                  70                  75                  80  


Gly Ala Leu Cys Leu Leu Leu Leu Met Ile Thr Leu Leu Leu Ile Ala 
                85                  90                  95      


Leu Trp Asn Leu His Gly Gln Ala Leu Tyr Leu Gly Ile Val Leu Phe 
            100                 105                 110         


Ile Phe Gly Cys Leu Leu Val Leu Gly Leu Trp Ile Tyr Leu Leu Glu 
        115                 120                 125             


Ile Leu Trp Arg Leu Gly Ala Thr Ile Trp Gln Leu Leu Ala Phe Phe 
    130                 135                 140                 


Leu Ala Phe Phe Leu Asp Ile Ile Leu Leu Ile Ile Ala Leu Tyr Leu 
145                 150                 155                 160 


Gln Gln Asn Trp Trp Thr Leu Leu Val Asp Leu Leu Trp Leu Leu Leu 
                165                 170                 175     


Phe Leu Ala Ile Leu Ile Trp Met Tyr Tyr His Gly Gln Arg Pro Ser 
            180                 185                 190         


Pro Arg His Cys Pro Val Glu Arg Glu Gln Phe Lys Arg Asp Ala Gln 
        195                 200                 205             


Pro Arg Pro Gly Gly Asp Pro Asp Ala Pro Pro Gly Pro Asn Gly Glu 
    210                 215                 220                 


Leu Leu Gln Ile Ser Pro Asn Glu Ala Val His Ile Gly Phe Thr Gly 
225                 230                 235                 240 


Glu Ser Lys Tyr Glu Asn Glu Glu Pro Gly His Cys Pro Gly Met Gly 
                245                 250                 255     


Leu Ser Thr Ser Ala Ser Ile Ala Leu Asp Glu Phe Cys Gly Ser Phe 
            260                 265                 270         


Pro Ser Asp Val Gln Ser Ala Leu Val Gly Pro Lys Ser Leu Glu Ser 
        275                 280                 285             


Gly Leu Gly Arg Asn Glu Ser Ser Ser Asp Leu Trp Ala Ser Ser Gly 
    290                 295                 300                 


Gly Thr Ala Gly Ala Pro Thr Pro Ala Ala Pro Thr Glu Glu Asn Arg 
305                 310                 315                 320 


Ser Ser Gly Asp Thr Pro Val Thr Ser Ala Ser Val Lys Thr Leu Val 
                325                 330                 335     


Met Ser Thr Pro Val Lys Ser Pro Val Met Gly Ala Arg Thr Ser Asn 
            340                 345                 350         


Ile Pro Leu Lys Ser Pro Ala Pro Asn Thr Leu Ala Asn Ser Pro Val 
        355                 360                 365             


Ala Gly Pro Pro Lys Ser Ser Thr Pro Leu Lys Ser Pro Val Thr Ser 
    370                 375                 380                 


Val Ser Ala Pro Asn Ala Pro Val Lys Leu Ala Val Thr Asn Val Pro 
385                 390                 395                 400 


Met Leu Thr Thr Pro Val Lys Ser Pro Leu Ser Asn Ala Pro Ala Glu 
                405                 410                 415     


Ala Gly Ser Ser Cys Ile Ile Pro Glu Ala Gln Asp Ser Glu Ala Gly 
            420                 425                 430         


Gln Lys Gly Glu Ala Ala Gly Ala Ser Ala Leu Gly Pro Ser Ser Ser 
        435                 440                 445             


Ser Phe Ser Thr Gly Thr Ser Val Val Ser Gly Thr Pro Gly Pro Leu 
    450                 455                 460                 


Arg Ser Ala Arg Pro Thr Ser Arg Ala Leu Pro Gln Phe Ser Val Ser 
465                 470                 475                 480 


Pro Ser Val Pro Gly Arg Ser Pro Thr Leu Ser Ser Thr Ala Gly Ala 
                485                 490                 495     


Thr His Thr Ser Gly Leu Glu Thr Asp Gln Glu Gln His Gly Ser Ser 
            500                 505                 510         


Thr Leu Pro Ser Leu Ala Ala Leu Asp Ser Ser Ser Glu Leu Pro Gly 
        515                 520                 525             


Gly Asp Pro Asn Arg Pro Ile Ala Arg Pro Ser Leu Thr Gln Leu Ala 
    530                 535                 540                 


Gln Glu Ser Asn Glu Gly Pro Ser Glu Pro Ala Gln Thr Glu Gln Val 
545                 550                 555                 560 


Pro Met Pro Tyr Ser Pro Glu Lys Glu Arg Cys Ser Asn Tyr Pro Ile 
                565                 570                 575     


Ser His Ala Ala Ala Pro Thr Pro Pro Gly Pro Arg Glu Ala Pro Leu 
            580                 585                 590         


Ser Pro Pro Glu Leu Pro Asp Pro Pro Arg Asp Ser Thr Arg Pro Gln 
        595                 600                 605             


Tyr Ser Gln Tyr Val Ser Ala Val Glu Asp Ala Leu Asp Val Leu Glu 
    610                 615                 620                 


Cys Gly Arg Leu Ala Ala Ile Phe Tyr Glu Val Trp Gly Pro Arg Arg 
625                 630                 635                 640 


Gln Leu Thr Asn Phe Leu His Trp Leu Thr Asp Arg Asn Gly Ser Leu 
                645                 650                 655     


Thr Cys Thr Ala Arg Leu Arg Asp Gln Asp Arg Ala Thr Leu Cys Pro 
            660                 665                 670         


Leu Tyr Pro Leu Ile Glu Val Val Asp Val Asn Cys Phe Asn Ser Phe 
        675                 680                 685             


Asn Arg Cys Ile Tyr Lys Tyr Thr Lys Asp Glu Ala Phe Pro Met His 
    690                 695                 700                 


Ser Asp Glu His His His Asp Asp Ser Leu Pro His Pro Gln Gln Ala 
705                 710                 715                 720 


Thr Asp Asp Ser Ser Asn Gln Ser Asp Ser Asn Ser Asn Glu Gly Arg 
                725                 730                 735     


His Leu Leu Leu Val Ser Gly Ala Gly Asp Gly Pro Pro Leu Cys Ser 
            740                 745                 750         


Gln Asn Leu Gly Ala Pro Gly Gly Gly Pro Asn Asn Gly Pro Gln Asp 
        755                 760                 765             


Pro Asp Asn Thr Asp Asp Asn Gly Pro Gln Asp Pro Asp Asn Thr Asp 
    770                 775                 780                 


Asp Asn Gly Pro His Asp Pro Leu Pro Gln Asp Pro Asp Asn Thr Asp 
785                 790                 795                 800 


Asp Asn Gly Pro Gln Asp Pro Asp Asn Thr Asp Asp Asn Gly Pro His 
                805                 810                 815     


Asp Pro Leu Pro His Asn Pro Ser Asp Ser Ala Gly Asn Asp Gly Gly 
            820                 825                 830         


Pro Pro Gln Leu Thr Glu Glu Val Glu Asn Lys Gly Gly Asp Gln Gly 
        835                 840                 845             


Pro Pro Leu Met Thr Asp Gly Gly Gly Gly His Ser His Asp Ser Gly 
    850                 855                 860                 


His Asp Gly Ile Asp Pro His Leu Pro Thr Leu Leu Leu Gly Thr Ser 
865                 870                 875                 880 


Gly Ser Gly Gly Asp Asp Asp Asp Pro His Gly Pro Val Gln Leu Ser 
                885                 890                 895     


Tyr Tyr Asp 
            


