                         SEQUENCE LISTING

<110>  Autolus Ltd
 
<120>  Signal transduction modifying protein

<130>  P111066PCT

<150>  GB 1620070.1
<151>  2016-11-28

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Val Arg Trp Phe His Arg Asp Leu Ser Gly Leu Asp Ala Glu Thr 
1               5                   10                  15      


Leu Leu Lys Gly Arg Gly Val His Gly Ser Phe Leu Ala Arg Pro Ser 
            20                  25                  30          


Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Val Arg Val Gly Asp Gln 
        35                  40                  45              


Val Thr His Ile Arg Ile Gln Asn Ser Gly Asp Phe Tyr Asp Leu Tyr 
    50                  55                  60                  


Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Leu Val Glu Tyr Tyr Thr 
65                  70                  75                  80  


Gln Gln Gln Gly Val Leu Gln Asp Arg Asp Gly Thr Ile Ile His Leu 
                85                  90                  95      


Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Ser Glu Arg Trp Tyr His 
            100                 105                 110         


Gly His Met Ser Gly Gly Gln Ala Glu Thr Leu Leu Gln Ala Lys Gly 
        115                 120                 125             


Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Leu Ser Gln Pro Gly Asp 
    130                 135                 140                 


Phe Val Leu Ser Val Leu Ser Asp Gln Pro Lys Ala Gly Pro Gly Ser 
145                 150                 155                 160 


Pro Leu Arg Val Thr His Ile Lys Val Met Cys Glu Gly Gly Arg Tyr 
                165                 170                 175     


Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Leu Thr Asp Leu Val Glu 
            180                 185                 190         


His Phe Lys Lys Thr Gly Ile Glu Glu Ala Ser Gly Ala Phe Val Tyr 
        195                 200                 205             


Leu Arg Gln Pro Tyr Tyr Ala Thr Arg Val Asn Ala Ala Asp Ile Glu 
    210                 215                 220                 


Asn Arg Val Leu Glu Leu Asn Lys Lys Gln Glu Ser Glu Asp Thr Ala 
225                 230                 235                 240 


Lys Ala Gly Phe Trp Glu Glu Phe Glu Ser Leu Gln Lys Gln Glu Val 
                245                 250                 255     


Lys Asn Leu His Gln Arg Leu Glu Gly Gln Arg Pro Glu Asn Lys Gly 
            260                 265                 270         


Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Ser Arg Val Ile 
        275                 280                 285             


Leu Gln Gly Arg Asp Ser Asn Ile Pro Gly Ser Asp Tyr Ile Asn Ala 
    290                 295                 300                 


Asn Tyr Ile Lys Asn Gln Leu Leu Gly Pro Asp Glu Asn Ala Lys Thr 
305                 310                 315                 320 


Tyr Ile Ala Ser Gln Gly Cys Leu Glu Ala Thr Val Asn Asp Phe Trp 
                325                 330                 335     


Gln Met Ala Trp Gln Glu Asn Ser Arg Val Ile Val Met Thr Thr Arg 
            340                 345                 350         


Glu Val Glu Lys Gly Arg Asn Lys Cys Val Pro Tyr Trp Pro Glu Val 
        355                 360                 365             


Gly Met Gln Arg Ala Tyr Gly Pro Tyr Ser Val Thr Asn Cys Gly Glu 
    370                 375                 380                 


His Asp Thr Thr Glu Tyr Lys Leu Arg Thr Leu Gln Val Ser Pro Leu 
385                 390                 395                 400 


Asp Asn Gly Asp Leu Ile Arg Glu Ile Trp His Tyr Gln Tyr Leu Ser 
                405                 410                 415     


Trp Pro Asp His Gly Val Pro Ser Glu Pro Gly Gly Val Leu Ser Phe 
            420                 425                 430         


Leu Asp Gln Ile Asn Gln Arg Gln Glu Ser Leu Pro His Ala Gly Pro 
        435                 440                 445             


Ile Ile Val His Cys Ser Ala Gly Ile Gly Arg Thr Gly Thr Ile Ile 
    450                 455                 460                 


Val Ile Asp Met Leu Met Glu Asn Ile Ser Thr Lys Gly Leu Asp Cys 
465                 470                 475                 480 


Asp Ile Asp Ile Gln Lys Thr Ile Gln Met Val Arg Ala Gln Arg Ser 
                485                 490                 495     


Gly Met Val Gln Thr Glu Ala Gln Tyr Lys Phe Ile Tyr Val Ala Ile 
            500                 505                 510         


Ala Gln Phe Ile Glu Thr Thr Lys Lys Lys Leu Glu Val Leu Gln Ser 
        515                 520                 525             


Gln Lys Gly Gln Glu Ser Glu Tyr Gly Asn Ile Thr Tyr Pro Pro Ala 
    530                 535                 540                 


Met Lys Asn Ala His Ala Lys Ala Ser Arg Thr Ser Ser Lys His Lys 
545                 550                 555                 560 


Glu Asp Val Tyr Glu Asn Leu His Thr Lys Asn Lys Arg Glu Glu Lys 
                565                 570                 575     


Val Lys Lys Gln Arg Ser Ala Asp Lys Glu Lys Ser Lys Gly Ser Leu 
            580                 585                 590         


Lys Arg Lys 
        595 


<210>  2
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Arg Trp Phe His Arg Asp Leu Ser Gly Leu Asp Ala Glu Thr 
1               5                   10                  15      


Leu Leu Lys Gly Arg Gly Val His Gly Ser Phe Leu Ala Arg Pro Ser 
            20                  25                  30          


Arg Lys Asn Gln Gly Asp Phe Ser Leu Ser Val Arg Val Gly Asp Gln 
        35                  40                  45              


Val Thr His Ile Arg Ile Gln Asn Ser Gly Asp Phe Tyr Asp Leu Tyr 
    50                  55                  60                  


Gly Gly Glu Lys Phe Ala Thr Leu Thr Glu Leu Val Glu Tyr Tyr Thr 
65                  70                  75                  80  


Gln Gln Gln Gly Val Leu Gln Asp Arg Asp Gly Thr Ile Ile His Leu 
                85                  90                  95      


Lys Tyr Pro Leu Asn Cys Ser Asp Pro Thr Ser Glu Arg Trp Tyr His 
            100                 105                 110         


Gly His Met Ser Gly Gly Gln Ala Glu Thr Leu Leu Gln Ala Lys Gly 
        115                 120                 125             


Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Leu Ser Gln Pro Gly Asp 
    130                 135                 140                 


Phe Val Leu Ser Val Leu Ser Asp Gln Pro Lys Ala Gly Pro Gly Ser 
145                 150                 155                 160 


Pro Leu Arg Val Thr His Ile Lys Val Met Cys Glu Gly Gly Arg Tyr 
                165                 170                 175     


Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Leu Thr Asp Leu Val Glu 
            180                 185                 190         


His Phe Lys Lys Thr Gly Ile Glu Glu Ala Ser Gly Ala Phe Val Tyr 
        195                 200                 205             


Leu Arg Gln Pro Tyr Tyr 
    210                 


<210>  3
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  3

Trp Phe His Arg Asp Leu Ser Gly Leu Asp Ala Glu Thr Leu Leu Lys 
1               5                   10                  15      


Gly Arg Gly Val His Gly Ser Phe Leu Ala Arg Pro Ser Arg Lys Asn 
            20                  25                  30          


Gln Gly Asp Phe Ser Leu Ser Val Arg Val Gly Asp Gln Val Thr His 
        35                  40                  45              


Ile Arg Ile Gln Asn Ser Gly Asp Phe Tyr Asp Leu Tyr Gly Gly Glu 
    50                  55                  60                  


Lys Phe Ala Thr Leu Thr Glu Leu Val Glu Tyr Tyr Thr Gln Gln Gln 
65                  70                  75                  80  


Gly Val Leu Gln Asp Arg Asp Gly Thr Ile Ile His Leu Lys Tyr Pro 
                85                  90                  95      


Leu 
    


<210>  4
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  4

Trp Tyr His Gly His Met Ser Gly Gly Gln Ala Glu Thr Leu Leu Gln 
1               5                   10                  15      


Ala Lys Gly Glu Pro Trp Thr Phe Leu Val Arg Glu Ser Leu Ser Gln 
            20                  25                  30          


Pro Gly Asp Phe Val Leu Ser Val Leu Ser Asp Gln Pro Lys Ala Gly 
        35                  40                  45              


Pro Gly Ser Pro Leu Arg Val Thr His Ile Lys Val Met Cys Glu Gly 
    50                  55                  60                  


Gly Arg Tyr Thr Val Gly Gly Leu Glu Thr Phe Asp Ser Leu Thr Asp 
65                  70                  75                  80  


Leu Val Glu His Phe Lys Lys Thr Gly Ile Glu Glu Ala Ser Gly Ala 
                85                  90                  95      


Phe Val Tyr Leu Arg Gln Pro Tyr 
            100                 


<210>  5
<211>  597
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Thr Ser Arg Arg Trp Phe His Pro Asn Ile Thr Gly Val Glu Ala 
1               5                   10                  15      


Glu Asn Leu Leu Leu Thr Arg Gly Val Asp Gly Ser Phe Leu Ala Arg 
            20                  25                  30          


Pro Ser Lys Ser Asn Pro Gly Asp Phe Thr Leu Ser Val Arg Arg Asn 
        35                  40                  45              


Gly Ala Val Thr His Ile Lys Ile Gln Asn Thr Gly Asp Tyr Tyr Asp 
    50                  55                  60                  


Leu Tyr Gly Gly Glu Lys Phe Ala Thr Leu Ala Glu Leu Val Gln Tyr 
65                  70                  75                  80  


Tyr Met Glu His His Gly Gln Leu Lys Glu Lys Asn Gly Asp Val Ile 
                85                  90                  95      


Glu Leu Lys Tyr Pro Leu Asn Cys Ala Asp Pro Thr Ser Glu Arg Trp 
            100                 105                 110         


Phe His Gly His Leu Ser Gly Lys Glu Ala Glu Lys Leu Leu Thr Glu 
        115                 120                 125             


Lys Gly Lys His Gly Ser Phe Leu Val Arg Glu Ser Gln Ser His Pro 
    130                 135                 140                 


Gly Asp Phe Val Leu Ser Val Arg Thr Gly Asp Asp Lys Gly Glu Ser 
145                 150                 155                 160 


Asn Asp Gly Lys Ser Lys Val Thr His Val Met Ile Arg Cys Gln Glu 
                165                 170                 175     


Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Phe Asp Ser Leu Thr Asp 
            180                 185                 190         


Leu Val Glu His Tyr Lys Lys Asn Pro Met Val Glu Thr Leu Gly Thr 
        195                 200                 205             


Val Leu Gln Leu Lys Gln Pro Leu Asn Thr Thr Arg Ile Asn Ala Ala 
    210                 215                 220                 


Glu Ile Glu Ser Arg Val Arg Glu Leu Ser Lys Leu Ala Glu Thr Thr 
225                 230                 235                 240 


Asp Lys Val Lys Gln Gly Phe Trp Glu Glu Phe Glu Thr Leu Gln Gln 
                245                 250                 255     


Gln Glu Cys Lys Leu Leu Tyr Ser Arg Lys Glu Gly Gln Arg Gln Glu 
            260                 265                 270         


Asn Lys Asn Lys Asn Arg Tyr Lys Asn Ile Leu Pro Phe Asp His Thr 
        275                 280                 285             


Arg Val Val Leu His Asp Gly Asp Pro Asn Glu Pro Val Ser Asp Tyr 
    290                 295                 300                 


Ile Asn Ala Asn Ile Ile Met Pro Glu Phe Glu Thr Lys Cys Asn Asn 
305                 310                 315                 320 


Ser Lys Pro Lys Lys Ser Tyr Ile Ala Thr Gln Gly Cys Leu Gln Asn 
                325                 330                 335     


Thr Val Asn Asp Phe Trp Arg Met Val Phe Gln Glu Asn Ser Arg Val 
            340                 345                 350         


Ile Val Met Thr Thr Lys Glu Val Glu Arg Gly Lys Ser Lys Cys Val 
        355                 360                 365             


Lys Tyr Trp Pro Asp Glu Tyr Ala Leu Lys Glu Tyr Gly Val Met Arg 
    370                 375                 380                 


Val Arg Asn Val Lys Glu Ser Ala Ala His Asp Tyr Thr Leu Arg Glu 
385                 390                 395                 400 


Leu Lys Leu Ser Lys Val Gly Gln Ala Leu Leu Gln Gly Asn Thr Glu 
                405                 410                 415     


Arg Thr Val Trp Gln Tyr His Phe Arg Thr Trp Pro Asp His Gly Val 
            420                 425                 430         


Pro Ser Asp Pro Gly Gly Val Leu Asp Phe Leu Glu Glu Val His His 
        435                 440                 445             


Lys Gln Glu Ser Ile Val Asp Ala Gly Pro Val Val Val His Cys Ser 
    450                 455                 460                 


Ala Gly Ile Gly Arg Thr Gly Thr Phe Ile Val Ile Asp Ile Leu Ile 
465                 470                 475                 480 


Asp Ile Ile Arg Glu Lys Gly Val Asp Cys Asp Ile Asp Val Pro Lys 
                485                 490                 495     


Thr Ile Gln Met Val Arg Ser Gln Arg Ser Gly Met Val Gln Thr Glu 
            500                 505                 510         


Ala Gln Tyr Arg Phe Ile Tyr Met Ala Val Gln His Tyr Ile Glu Thr 
        515                 520                 525             


Leu Gln Arg Arg Ile Glu Glu Glu Gln Lys Ser Lys Arg Lys Gly His 
    530                 535                 540                 


Glu Tyr Thr Asn Ile Lys Tyr Ser Leu Val Asp Gln Thr Ser Gly Asp 
545                 550                 555                 560 


Gln Ser Pro Leu Pro Pro Cys Thr Pro Thr Pro Pro Cys Ala Glu Met 
                565                 570                 575     


Arg Glu Asp Ser Ala Arg Val Tyr Glu Asn Val Gly Leu Met Gln Gln 
            580                 585                 590         


Gln Arg Ser Phe Arg 
        595         


<210>  6
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  6

Trp Phe His Pro Asn Ile Thr Gly Val Glu Ala Glu Asn Leu Leu Leu 
1               5                   10                  15      


Thr Arg Gly Val Asp Gly Ser Phe Leu Ala Arg Pro Ser Lys Ser Asn 
            20                  25                  30          


Pro Gly Asp Phe Thr Leu Ser Val Arg Arg Asn Gly Ala Val Thr His 
        35                  40                  45              


Ile Lys Ile Gln Asn Thr Gly Asp Tyr Tyr Asp Leu Tyr Gly Gly Glu 
    50                  55                  60                  


Lys Phe Ala Thr Leu Ala Glu Leu Val Gln Tyr Tyr Met Glu His His 
65                  70                  75                  80  


Gly Gln Leu Lys Glu Lys Asn Gly Asp Val Ile Glu Leu Lys Tyr Pro 
                85                  90                  95      


Leu 
    


<210>  7
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  7

Trp Phe His Gly His Leu Ser Gly Lys Glu Ala Glu Lys Leu Leu Thr 
1               5                   10                  15      


Glu Lys Gly Lys His Gly Ser Phe Leu Val Arg Glu Ser Gln Ser His 
            20                  25                  30          


Pro Gly Asp Phe Val Leu Ser Val Arg Thr Gly Asp Asp Lys Gly Glu 
        35                  40                  45              


Ser Asn Asp Gly Lys Ser Lys Val Thr His Val Met Ile Arg Cys Gln 
    50                  55                  60                  


Glu Leu Lys Tyr Asp Val Gly Gly Gly Glu Arg Phe Asp Ser Leu Thr 
65                  70                  75                  80  


Asp Leu Val Glu His Tyr Lys Lys Asn Pro Met Val Glu Thr Leu Gly 
                85                  90                  95      


Thr Val Leu Gln Leu Lys Gln Pro Leu 
            100                 105 


<210>  8
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  8

Trp Phe His Pro Asn Ile Thr Gly Val Glu Ala Glu Asn Leu Leu Leu 
1               5                   10                  15      


Thr Arg Gly Val Asp Gly Ser Phe Leu Ala Arg Pro Ser Lys Ser Asn 
            20                  25                  30          


Pro Gly Asp Phe Thr Leu Ser Val Arg Arg Asn Gly Ala Val Thr His 
        35                  40                  45              


Ile Lys Ile Gln Asn Thr Gly Asp Tyr Tyr Asp Leu Tyr Gly Gly Glu 
    50                  55                  60                  


Lys Phe Ala Thr Leu Ala Glu Leu Val Gln Tyr Tyr Met Glu His His 
65                  70                  75                  80  


Gly Gln Leu Lys Glu Lys Asn Gly Asp Val Ile Glu Leu Lys Tyr Pro 
                85                  90                  95      


Leu Asn Cys Ala Asp Pro Thr Ser Glu Arg Trp Phe His Gly His Leu 
            100                 105                 110         


Ser Gly Lys Glu Ala Glu Lys Leu Leu Thr Glu Lys Gly Lys His Gly 
        115                 120                 125             


Ser Phe Leu Val Arg Glu Ser Gln Ser His Pro Gly Asp Phe Val Leu 
    130                 135                 140                 


Ser Val Arg Thr Gly Asp Asp Lys Gly Glu Ser Asn Asp Gly Lys Ser 
145                 150                 155                 160 


Lys Val Thr His Val Met Ile Arg Cys Gln Glu Leu Lys Tyr Asp Val 
                165                 170                 175     


Gly Gly Gly Glu Arg Phe Asp Ser Leu Thr Asp Leu Val Glu His Tyr 
            180                 185                 190         


Lys Lys Asn Pro Met Val Glu Thr Leu Gly Thr Val Leu Gln Leu Lys 
        195                 200                 205             


Gln Pro Leu 
    210     


<210>  9
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  9

Phe Trp Glu Glu Phe Glu Ser Leu Gln Lys Gln Glu Val Lys Asn Leu 
1               5                   10                  15      


His Gln Arg Leu Glu Gly Gln Arg Pro Glu Asn Lys Gly Lys Asn Arg 
            20                  25                  30          


Tyr Lys Asn Ile Leu Pro Phe Asp His Ser Arg Val Ile Leu Gln Gly 
        35                  40                  45              


Arg Asp Ser Asn Ile Pro Gly Ser Asp Tyr Ile Asn Ala Asn Tyr Ile 
    50                  55                  60                  


Lys Asn Gln Leu Leu Gly Pro Asp Glu Asn Ala Lys Thr Tyr Ile Ala 
65                  70                  75                  80  


Ser Gln Gly Cys Leu Glu Ala Thr Val Asn Asp Phe Trp Gln Met Ala 
                85                  90                  95      


Trp Gln Glu Asn Ser Arg Val Ile Val Met Thr Thr Arg Glu Val Glu 
            100                 105                 110         


Lys Gly Arg Asn Lys Cys Val Pro Tyr Trp Pro Glu Val Gly Met Gln 
        115                 120                 125             


Arg Ala Tyr Gly Pro Tyr Ser Val Thr Asn Cys Gly Glu His Asp Thr 
    130                 135                 140                 


Thr Glu Tyr Lys Leu Arg Thr Leu Gln Val Ser Pro Leu Asp Asn Gly 
145                 150                 155                 160 


Asp Leu Ile Arg Glu Ile Trp His Tyr Gln Tyr Leu Ser Trp Pro Asp 
                165                 170                 175     


His Gly Val Pro Ser Glu Pro Gly Gly Val Leu Ser Phe Leu Asp Gln 
            180                 185                 190         


Ile Asn Gln Arg Gln Glu Ser Leu Pro His Ala Gly Pro Ile Ile Val 
        195                 200                 205             


His Cys Ser Ala Gly Ile Gly Arg Thr Gly Thr Ile Ile Val Ile Asp 
    210                 215                 220                 


Met Leu Met Glu Asn Ile Ser Thr Lys Gly Leu Asp Cys Asp Ile Asp 
225                 230                 235                 240 


Ile Gln Lys Thr Ile Gln Met Val Arg Ala Gln Arg Ser Gly Met Val 
                245                 250                 255     


Gln Thr Glu Ala Gln Tyr Lys Phe Ile Tyr Val Ala Ile Ala Gln Phe 
            260                 265                 270         


<210>  10
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  10

Phe Trp Glu Glu Phe Glu Thr Leu Gln Gln Gln Glu Cys Lys Leu Leu 
1               5                   10                  15      


Tyr Ser Arg Lys Glu Gly Gln Arg Gln Glu Asn Lys Asn Lys Asn Arg 
            20                  25                  30          


Tyr Lys Asn Ile Leu Pro Phe Asp His Thr Arg Val Val Leu His Asp 
        35                  40                  45              


Gly Asp Pro Asn Glu Pro Val Ser Asp Tyr Ile Asn Ala Asn Ile Ile 
    50                  55                  60                  


Met Pro Glu Phe Glu Thr Lys Cys Asn Asn Ser Lys Pro Lys Lys Ser 
65                  70                  75                  80  


Tyr Ile Ala Thr Gln Gly Cys Leu Gln Asn Thr Val Asn Asp Phe Trp 
                85                  90                  95      


Arg Met Val Phe Gln Glu Asn Ser Arg Val Ile Val Met Thr Thr Lys 
            100                 105                 110         


Glu Val Glu Arg Gly Lys Ser Lys Cys Val Lys Tyr Trp Pro Asp Glu 
        115                 120                 125             


Tyr Ala Leu Lys Glu Tyr Gly Val Met Arg Val Arg Asn Val Lys Glu 
    130                 135                 140                 


Ser Ala Ala His Asp Tyr Thr Leu Arg Glu Leu Lys Leu Ser Lys Val 
145                 150                 155                 160 


Gly Gln Ala Leu Leu Gln Gly Asn Thr Glu Arg Thr Val Trp Gln Tyr 
                165                 170                 175     


His Phe Arg Thr Trp Pro Asp His Gly Val Pro Ser Asp Pro Gly Gly 
            180                 185                 190         


Val Leu Asp Phe Leu Glu Glu Val His His Lys Gln Glu Ser Ile Met 
        195                 200                 205             


Asp Ala Gly Pro Val Val Val His Cys Ser Ala Gly Ile Gly Arg Thr 
    210                 215                 220                 


Gly Thr Phe Ile Val Ile Asp Ile Leu Ile Asp Ile Ile Arg Glu Lys 
225                 230                 235                 240 


Gly Val Asp Cys Asp Ile Asp Val Pro Lys Thr Ile Gln Met Val Arg 
                245                 250                 255     


Ser Gln Arg Ser Gly Met Val Gln Thr Glu Ala Gln Tyr Arg Phe Ile 
            260                 265                 270         


Tyr Met Ala 
        275 


<210>  11
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant phosphatase sequence

<400>  11

Phe Trp Glu Glu Phe Glu Ser Leu Gln Lys Gln Glu Val Lys Asn Leu 
1               5                   10                  15      


His Gln Arg Leu Glu Gly Gln Arg Pro Glu Asn Lys Gly Lys Asn Arg 
            20                  25                  30          


Tyr Lys Asn Ile Leu Pro Phe Asp His Ser Arg Val Ile Leu Gln Gly 
        35                  40                  45              


Arg Asp Ser Asn Ile Pro Gly Ser Asp Tyr Ile Asn Ala Asn Tyr Ile 
    50                  55                  60                  


Lys Asn Gln Leu Leu Gly Pro Asp Glu Asn Ala Lys Thr Tyr Ile Ala 
65                  70                  75                  80  


Ser Gln Gly Cys Leu Glu Ala Thr Val Asn Asp Phe Trp Gln Met Ala 
                85                  90                  95      


Trp Gln Glu Asn Ser Arg Val Ile Val Met Thr Thr Arg Glu Val Glu 
            100                 105                 110         


Lys Gly Arg Asn Lys Cys Val Pro Tyr Trp Pro Glu Val Gly Met Gln 
        115                 120                 125             


Arg Ala Tyr Gly Pro Tyr Ser Val Thr Asn Cys Gly Glu His Asp Thr 
    130                 135                 140                 


Thr Glu Tyr Lys Leu Arg Thr Leu Gln Val Ser Pro Leu Asp Asn Gly 
145                 150                 155                 160 


Asp Leu Ile Arg Glu Ile Trp His Tyr Gln Tyr Leu Ser Trp Pro Asp 
                165                 170                 175     


His Gly Val Pro Ser Glu Pro Gly Gly Val Leu Ser Phe Leu Asp Gln 
            180                 185                 190         


Ile Asn Gln Arg Gln Glu Ser Leu Pro His Ala Gly Pro Ile Ile Val 
        195                 200                 205             


His Ser Ser Ala Gly Ile Gly Arg Thr Gly Thr Ile Ile Val Ile Asp 
    210                 215                 220                 


Met Leu Met Glu Asn Ile Ser Thr Lys Gly Leu Asp Cys Asp Ile Asp 
225                 230                 235                 240 


Ile Gln Lys Thr Ile Gln Met Val Arg Ala Gln Arg Ser Gly Met Val 
                245                 250                 255     


Gln Thr Glu Ala Gln Tyr Lys Phe Ile Tyr Val Ala Ile Ala Gln Phe 
            260                 265                 270         


<210>  12
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant phosphatase sequence

<400>  12

Phe Trp Glu Glu Phe Glu Thr Leu Gln Gln Gln Glu Cys Lys Leu Leu 
1               5                   10                  15      


Tyr Ser Arg Lys Glu Gly Gln Arg Gln Glu Asn Lys Asn Lys Asn Arg 
            20                  25                  30          


Tyr Lys Asn Ile Leu Pro Phe Asp His Thr Arg Val Val Leu His Asp 
        35                  40                  45              


Gly Asp Pro Asn Glu Pro Val Ser Asp Tyr Ile Asn Ala Asn Ile Ile 
    50                  55                  60                  


Met Pro Glu Phe Glu Thr Lys Cys Asn Asn Ser Lys Pro Lys Lys Ser 
65                  70                  75                  80  


Tyr Ile Ala Thr Gln Gly Cys Leu Gln Asn Thr Val Asn Asp Phe Trp 
                85                  90                  95      


Arg Met Val Phe Gln Glu Asn Ser Arg Val Ile Val Met Thr Thr Lys 
            100                 105                 110         


Glu Val Glu Arg Gly Lys Ser Lys Cys Val Lys Tyr Trp Pro Asp Glu 
        115                 120                 125             


Tyr Ala Leu Lys Glu Tyr Gly Val Met Arg Val Arg Asn Val Lys Glu 
    130                 135                 140                 


Ser Ala Ala His Asp Tyr Thr Leu Arg Glu Leu Lys Leu Ser Lys Val 
145                 150                 155                 160 


Gly Gln Ala Leu Leu Gln Gly Asn Thr Glu Arg Thr Val Trp Gln Tyr 
                165                 170                 175     


His Phe Arg Thr Trp Pro Asp His Gly Val Pro Ser Asp Pro Gly Gly 
            180                 185                 190         


Val Leu Asp Phe Leu Glu Glu Val His His Lys Gln Glu Ser Ile Met 
        195                 200                 205             


Asp Ala Gly Pro Val Val Val His Ser Ser Ala Gly Ile Gly Arg Thr 
    210                 215                 220                 


Gly Thr Phe Ile Val Ile Asp Ile Leu Ile Asp Ile Ile Arg Glu Lys 
225                 230                 235                 240 


Gly Val Asp Cys Asp Ile Asp Val Pro Lys Thr Ile Gln Met Val Arg 
                245                 250                 255     


Ser Gln Arg Ser Gly Met Val Gln Thr Glu Ala Gln Tyr Arg Phe Ile 
            260                 265                 270         


Tyr Met Ala 
        275 


<210>  13
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino terminal sequence of lck

<400>  13

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr 
65                  70          


<210>  14
<211>  20
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  14

Arg Ala Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  15
<211>  20
<212>  PRT
<213>  Foot-and-mouth disease virus

<400>  15

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  16
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITIM conserved sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa may be Ser, Ile, Val or Leu

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa may be Ile, Val or Leu

<400>  16

Xaa Xaa Tyr Xaa Xaa Xaa 
1               5       


<210>  17
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alternative SHP-1 sequence

<400>  17

Met Leu Ser Arg Gly 
1               5   


<210>  18
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  18

Ser Leu Ser Val Arg 
1               5   


<210>  19
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alternative SHP-1 sequence

<400>  19

Met Leu Ser Arg Gly 
1               5   


<210>  20
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  20

His Lys Glu Asp Val Tyr Glu Asn Leu His 
1               5                   10  


<210>  21
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  21

Glu Lys Ser Lys Gly Ser Leu Lys Arg Lys 
1               5                   10  


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alternative SHP-1 sequence

<400>  22

Ser Leu Glu Ser Ser Ala Gly Thr Val Ala 
1               5                   10  


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alternative SHP-1 sequence

<400>  23

Cys Thr Leu Arg Thr Arg Gly Arg Arg Lys 
1               5                   10  


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  myristoylation consensus site


<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  24

Gly Xaa Xaa Xaa Ser Xaa Xaa Xaa 
1               5               


