                         SEQUENCE LISTING

<110>  GlaxoSmithKline Biologicals SA
 
<120>  nOMV-ANTIGEN CONJUGATES AND USE THEREOF

<130>  VB66223

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  247
<212>  PRT
<213>  Neisseria meningitidis

<400>  1

Val Ala Ala Asp Ile Gly Ala Gly Leu Ala Asp Ala Leu Thr Ala Pro 
1               5                   10                  15      


Leu Asp His Lys Asp Lys Ser Leu Gln Ser Leu Thr Leu Asp Gln Ser 
            20                  25                  30          


Val Arg Lys Asn Glu Lys Leu Lys Leu Ala Ala Gln Gly Ala Glu Lys 
        35                  40                  45              


Thr Tyr Gly Asn Gly Asp Ser Leu Asn Thr Gly Lys Leu Lys Asn Asp 
    50                  55                  60                  


Lys Val Ser Arg Phe Asp Phe Ile Arg Gln Ile Glu Val Asp Gly Gln 
65                  70                  75                  80  


Leu Ile Thr Leu Glu Ser Gly Glu Phe Gln Ile Tyr Lys Gln Asp His 
                85                  90                  95      


Ser Ala Val Val Ala Leu Gln Ile Glu Lys Ile Asn Asn Pro Asp Lys 
            100                 105                 110         


Ile Asp Ser Leu Ile Asn Gln Arg Ser Phe Arg Val Ser Gly Leu Gly 
        115                 120                 125             


Gly Glu His Thr Ala Phe Asn Gln Leu Pro Asp Gly Lys Ala Glu Tyr 
    130                 135                 140                 


His Gly Lys Ala Phe Ser Ser Asp Asp Ala Gly Gly Lys Leu Thr Tyr 
145                 150                 155                 160 


Thr Ile Asp Phe Ala Ala Lys Gln Gly His Gly Lys Ile Glu His Leu 
                165                 170                 175     


Lys Thr Pro Glu Gln Asn Val Glu Leu Ala Ala Ala Glu Leu Lys Ala 
            180                 185                 190         


Asp Glu Lys Ser His Ala Val Ile Leu Gly Asp Thr Arg Tyr Gly Ser 
        195                 200                 205             


Glu Glu Lys Gly Thr Tyr His Leu Ala Leu Phe Gly Asp Arg Ala Gln 
    210                 215                 220                 


Glu Ile Ala Gly Ser Ala Thr Val Lys Ile Gly Glu Lys Val His Glu 
225                 230                 235                 240 


Ile Gly Ile Ala Gly Lys Gln 
                245         


<210>  2
<211>  488
<212>  PRT
<213>  Neisseria meningitidis

<400>  2

Met Phe Lys Arg Ser Val Ile Ala Met Ala Cys Ile Phe Ala Leu Ser 
1               5                   10                  15      


Ala Cys Gly Gly Gly Gly Gly Gly Ser Pro Asp Val Lys Ser Ala Asp 
            20                  25                  30          


Thr Leu Ser Lys Pro Ala Ala Pro Val Val Ser Glu Lys Glu Thr Glu 
        35                  40                  45              


Ala Lys Glu Asp Ala Pro Gln Ala Gly Ser Gln Gly Gln Gly Ala Pro 
    50                  55                  60                  


Ser Ala Gln Gly Ser Gln Asp Met Ala Ala Val Ser Glu Glu Asn Thr 
65                  70                  75                  80  


Gly Asn Gly Gly Ala Val Thr Ala Asp Asn Pro Lys Asn Glu Asp Glu 
                85                  90                  95      


Val Ala Gln Asn Asp Met Pro Gln Asn Ala Ala Gly Thr Asp Ser Ser 
            100                 105                 110         


Thr Pro Asn His Thr Pro Asp Pro Asn Met Leu Ala Gly Asn Met Glu 
        115                 120                 125             


Asn Gln Ala Thr Asp Ala Gly Glu Ser Ser Gln Pro Ala Asn Gln Pro 
    130                 135                 140                 


Asp Met Ala Asn Ala Ala Asp Gly Met Gln Gly Asp Asp Pro Ser Ala 
145                 150                 155                 160 


Gly Gly Gln Asn Ala Gly Asn Thr Ala Ala Gln Gly Ala Asn Gln Ala 
                165                 170                 175     


Gly Asn Asn Gln Ala Ala Gly Ser Ser Asp Pro Ile Pro Ala Ser Asn 
            180                 185                 190         


Pro Ala Pro Ala Asn Gly Gly Ser Asn Phe Gly Arg Val Asp Leu Ala 
        195                 200                 205             


Asn Gly Val Leu Ile Asp Gly Pro Ser Gln Asn Ile Thr Leu Thr His 
    210                 215                 220                 


Cys Lys Gly Asp Ser Cys Ser Gly Asn Asn Phe Leu Asp Glu Glu Val 
225                 230                 235                 240 


Gln Leu Lys Ser Glu Phe Glu Lys Leu Ser Asp Ala Asp Lys Ile Ser 
                245                 250                 255     


Asn Tyr Lys Lys Asp Gly Lys Asn Asp Lys Phe Val Gly Leu Val Ala 
            260                 265                 270         


Asp Ser Val Gln Met Lys Gly Ile Asn Gln Tyr Ile Ile Phe Tyr Lys 
        275                 280                 285             


Pro Lys Pro Thr Ser Phe Ala Arg Phe Arg Arg Ser Ala Arg Ser Arg 
    290                 295                 300                 


Arg Ser Leu Pro Ala Glu Met Pro Leu Ile Pro Val Asn Gln Ala Asp 
305                 310                 315                 320 


Thr Leu Ile Val Asp Gly Glu Ala Val Ser Leu Thr Gly His Ser Gly 
                325                 330                 335     


Asn Ile Phe Ala Pro Glu Gly Asn Tyr Arg Tyr Leu Thr Tyr Gly Ala 
            340                 345                 350         


Glu Lys Leu Pro Gly Gly Ser Tyr Ala Leu Arg Val Gln Gly Glu Pro 
        355                 360                 365             


Ala Lys Gly Glu Met Leu Ala Gly Ala Ala Val Tyr Asn Gly Glu Val 
    370                 375                 380                 


Leu His Phe His Thr Glu Asn Gly Arg Pro Tyr Pro Thr Arg Gly Arg 
385                 390                 395                 400 


Phe Ala Ala Lys Val Asp Phe Gly Ser Lys Ser Val Asp Gly Ile Ile 
                405                 410                 415     


Asp Ser Gly Asp Asp Leu His Met Gly Thr Gln Lys Phe Lys Ala Ala 
            420                 425                 430         


Ile Asp Gly Asn Gly Phe Lys Gly Thr Trp Thr Glu Asn Gly Ser Gly 
        435                 440                 445             


Asp Val Ser Gly Lys Phe Tyr Gly Pro Ala Gly Glu Glu Val Ala Gly 
    450                 455                 460                 


Lys Tyr Ser Tyr Arg Pro Thr Asp Ala Glu Lys Gly Gly Phe Gly Val 
465                 470                 475                 480 


Phe Ala Gly Lys Lys Glu Gln Asp 
                485             


<210>  3
<211>  362
<212>  PRT
<213>  Neisseria meningitidis

<400>  3

Met Lys His Phe Pro Ser Lys Val Leu Thr Thr Ala Ile Leu Ala Thr 
1               5                   10                  15      


Phe Cys Ser Gly Ala Leu Ala Ala Thr Ser Asp Asp Asp Val Lys Lys 
            20                  25                  30          


Ala Ala Thr Val Ala Ile Val Ala Ala Tyr Asn Asn Gly Gln Glu Ile 
        35                  40                  45              


Asn Gly Phe Lys Ala Gly Glu Thr Ile Tyr Asp Ile Gly Glu Asp Gly 
    50                  55                  60                  


Thr Ile Thr Gln Lys Asp Ala Thr Ala Ala Asp Val Glu Ala Asp Asp 
65                  70                  75                  80  


Phe Lys Gly Leu Gly Leu Lys Lys Val Val Thr Asn Leu Thr Lys Thr 
                85                  90                  95      


Val Asn Glu Asn Lys Gln Asn Val Asp Ala Lys Val Lys Ala Ala Glu 
            100                 105                 110         


Ser Glu Ile Glu Lys Leu Thr Thr Lys Leu Ala Asp Thr Asp Ala Ala 
        115                 120                 125             


Leu Ala Asp Thr Asp Ala Ala Leu Asp Glu Thr Thr Asn Ala Leu Asn 
    130                 135                 140                 


Lys Leu Gly Glu Asn Ile Thr Thr Phe Ala Glu Glu Thr Lys Thr Asn 
145                 150                 155                 160 


Ile Val Lys Ile Asp Glu Lys Leu Glu Ala Val Ala Asp Thr Val Asp 
                165                 170                 175     


Lys His Ala Glu Ala Phe Asn Asp Ile Ala Asp Ser Leu Asp Glu Thr 
            180                 185                 190         


Asn Thr Lys Ala Asp Glu Ala Val Lys Thr Ala Asn Glu Ala Lys Gln 
        195                 200                 205             


Thr Ala Glu Glu Thr Lys Gln Asn Val Asp Ala Lys Val Lys Ala Ala 
    210                 215                 220                 


Glu Thr Ala Ala Gly Lys Ala Glu Ala Ala Ala Gly Thr Ala Asn Thr 
225                 230                 235                 240 


Ala Ala Asp Lys Ala Glu Ala Val Ala Ala Lys Val Thr Asp Ile Lys 
                245                 250                 255     


Ala Asp Ile Ala Thr Asn Lys Ala Asp Ile Ala Lys Asn Ser Ala Arg 
            260                 265                 270         


Ile Asp Ser Leu Asp Lys Asn Val Ala Asn Leu Arg Lys Glu Thr Arg 
        275                 280                 285             


Gln Gly Leu Ala Glu Gln Ala Ala Leu Ser Gly Leu Phe Gln Pro Tyr 
    290                 295                 300                 


Asn Val Gly Arg Phe Asn Val Thr Ala Ala Val Gly Gly Tyr Lys Ser 
305                 310                 315                 320 


Glu Ser Ala Val Ala Ile Gly Thr Gly Phe Arg Phe Thr Glu Asn Phe 
                325                 330                 335     


Ala Ala Lys Ala Gly Val Ala Val Gly Thr Ser Ser Gly Ser Ser Ala 
            340                 345                 350         


Ala Tyr His Val Gly Val Asn Tyr Glu Trp 
        355                 360         


<210>  4
<211>  174
<212>  PRT
<213>  Neisseria meningitidis

<400>  4

Met Lys Lys Ala Leu Ala Thr Leu Ile Ala Leu Ala Leu Pro Ala Ala 
1               5                   10                  15      


Ala Leu Ala Glu Gly Ala Ser Gly Phe Tyr Val Gln Ala Asp Ala Ala 
            20                  25                  30          


His Ala Lys Ala Ser Ser Ser Leu Gly Ser Ala Lys Gly Phe Ser Pro 
        35                  40                  45              


Arg Ile Ser Ala Gly Tyr Arg Ile Asn Asp Leu Arg Phe Ala Val Asp 
    50                  55                  60                  


Tyr Thr Arg Tyr Lys Asn Tyr Lys Ala Pro Ser Thr Asp Phe Lys Leu 
65                  70                  75                  80  


Tyr Ser Ile Gly Ala Ser Ala Ile Tyr Asp Phe Asp Thr Gln Ser Pro 
                85                  90                  95      


Val Lys Pro Tyr Leu Gly Ala Arg Leu Ser Leu Asn Arg Ala Ser Val 
            100                 105                 110         


Asp Leu Gly Gly Ser Asp Ser Phe Ser Gln Thr Ser Ile Gly Leu Gly 
        115                 120                 125             


Val Leu Thr Gly Val Ser Tyr Ala Val Thr Pro Asn Val Asp Leu Asp 
    130                 135                 140                 


Ala Gly Tyr Arg Tyr Asn Tyr Ile Gly Lys Val Asn Thr Val Lys Asn 
145                 150                 155                 160 


Val Arg Ser Gly Glu Leu Ser Ala Gly Val Arg Val Lys Phe 
                165                 170                 


<210>  5
<211>  591
<212>  PRT
<213>  Neisseria meningitidis

<400>  5

Met Asn Lys Ile Tyr Arg Ile Ile Trp Asn Ser Ala Leu Asn Ala Trp 
1               5                   10                  15      


Val Val Val Ser Glu Leu Thr Arg Asn His Thr Lys Arg Ala Ser Ala 
            20                  25                  30          


Thr Val Lys Thr Ala Val Leu Ala Thr Leu Leu Phe Ala Thr Val Gln 
        35                  40                  45              


Ala Ser Ala Asn Asn Glu Glu Gln Glu Glu Asp Leu Tyr Leu Asp Pro 
    50                  55                  60                  


Val Gln Arg Thr Val Ala Val Leu Ile Val Asn Ser Asp Lys Glu Gly 
65                  70                  75                  80  


Thr Gly Glu Lys Glu Lys Val Glu Glu Asn Ser Asp Trp Ala Val Tyr 
                85                  90                  95      


Phe Asn Glu Lys Gly Val Leu Thr Ala Arg Glu Ile Thr Leu Lys Ala 
            100                 105                 110         


Gly Asp Asn Leu Lys Ile Lys Gln Asn Gly Thr Asn Phe Thr Tyr Ser 
        115                 120                 125             


Leu Lys Lys Asp Leu Thr Asp Leu Thr Ser Val Gly Thr Glu Lys Leu 
    130                 135                 140                 


Ser Phe Ser Ala Asn Gly Asn Lys Val Asn Ile Thr Ser Asp Thr Lys 
145                 150                 155                 160 


Gly Leu Asn Phe Ala Lys Glu Thr Ala Gly Thr Asn Gly Asp Thr Thr 
                165                 170                 175     


Val His Leu Asn Gly Ile Gly Ser Thr Leu Thr Asp Thr Leu Leu Asn 
            180                 185                 190         


Thr Gly Ala Thr Thr Asn Val Thr Asn Asp Asn Val Thr Asp Asp Glu 
        195                 200                 205             


Lys Lys Arg Ala Ala Ser Val Lys Asp Val Leu Asn Ala Gly Trp Asn 
    210                 215                 220                 


Ile Lys Gly Val Lys Pro Gly Thr Thr Ala Ser Asp Asn Val Asp Phe 
225                 230                 235                 240 


Val Arg Thr Tyr Asp Thr Val Glu Phe Leu Ser Ala Asp Thr Lys Thr 
                245                 250                 255     


Thr Thr Val Asn Val Glu Ser Lys Asp Asn Gly Lys Lys Thr Glu Val 
            260                 265                 270         


Lys Ile Gly Ala Lys Thr Ser Val Ile Lys Glu Lys Asp Gly Lys Leu 
        275                 280                 285             


Val Thr Gly Lys Asp Lys Gly Glu Asn Gly Ser Ser Thr Asp Glu Gly 
    290                 295                 300                 


Glu Gly Leu Val Thr Ala Lys Glu Val Ile Asp Ala Val Asn Lys Ala 
305                 310                 315                 320 


Gly Trp Arg Met Lys Thr Thr Thr Ala Asn Gly Gln Thr Gly Gln Ala 
                325                 330                 335     


Asp Lys Phe Glu Thr Val Thr Ser Gly Thr Asn Val Thr Phe Ala Ser 
            340                 345                 350         


Gly Lys Gly Thr Thr Ala Thr Val Ser Lys Asp Asp Gln Gly Asn Ile 
        355                 360                 365             


Thr Val Met Tyr Asp Val Asn Val Gly Asp Ala Leu Asn Val Asn Gln 
    370                 375                 380                 


Leu Gln Asn Ser Gly Trp Asn Leu Asp Ser Lys Ala Val Ala Gly Ser 
385                 390                 395                 400 


Ser Gly Lys Val Ile Ser Gly Asn Val Ser Pro Ser Lys Gly Lys Met 
                405                 410                 415     


Asp Glu Thr Val Asn Ile Asn Ala Gly Asn Asn Ile Glu Ile Thr Arg 
            420                 425                 430         


Asn Gly Lys Asn Ile Asp Ile Ala Thr Ser Met Thr Pro Gln Phe Ser 
        435                 440                 445             


Ser Val Ser Leu Gly Ala Gly Ala Asp Ala Pro Thr Leu Ser Val Asp 
    450                 455                 460                 


Gly Asp Ala Leu Asn Val Gly Ser Lys Lys Asp Asn Lys Pro Val Arg 
465                 470                 475                 480 


Ile Thr Asn Val Ala Pro Gly Val Lys Glu Gly Asp Val Thr Asn Val 
                485                 490                 495     


Ala Gln Leu Lys Gly Val Ala Gln Asn Leu Asn Asn Arg Ile Asp Asn 
            500                 505                 510         


Val Asp Gly Asn Ala Arg Ala Gly Ile Ala Gln Ala Ile Ala Thr Ala 
        515                 520                 525             


Gly Leu Val Gln Ala Tyr Leu Pro Gly Lys Ser Met Met Ala Ile Gly 
    530                 535                 540                 


Gly Gly Thr Tyr Arg Gly Glu Ala Gly Tyr Ala Ile Gly Tyr Ser Ser 
545                 550                 555                 560 


Ile Ser Asp Gly Gly Asn Trp Ile Ile Lys Gly Thr Ala Ser Gly Asn 
                565                 570                 575     


Ser Arg Gly His Phe Gly Ala Ser Ala Ser Val Gly Tyr Gln Trp 
            580                 585                 590     


<210>  6
<211>  1457
<212>  PRT
<213>  Neisseria meningitidis

<400>  6

Met Lys Thr Thr Asp Lys Arg Thr Thr Glu Thr His Arg Lys Ala Pro 
1               5                   10                  15      


Lys Thr Gly Arg Ile Arg Phe Ser Pro Ala Tyr Leu Ala Ile Cys Leu 
            20                  25                  30          


Ser Phe Gly Ile Leu Pro Gln Ala Trp Ala Gly His Thr Tyr Phe Gly 
        35                  40                  45              


Ile Asn Tyr Gln Tyr Tyr Arg Asp Phe Ala Glu Asn Lys Gly Lys Phe 
    50                  55                  60                  


Ala Val Gly Ala Lys Asp Ile Glu Val Tyr Asn Lys Lys Gly Glu Leu 
65                  70                  75                  80  


Val Gly Lys Ser Met Thr Lys Ala Pro Met Ile Asp Phe Ser Val Val 
                85                  90                  95      


Ser Arg Asn Gly Val Ala Ala Leu Val Gly Asp Gln Tyr Ile Val Ser 
            100                 105                 110         


Val Ala His Asn Gly Gly Tyr Asn Asn Val Asp Phe Gly Ala Glu Gly 
        115                 120                 125             


Arg Asn Pro Asp Gln His Arg Phe Thr Tyr Lys Ile Val Lys Arg Asn 
    130                 135                 140                 


Asn Tyr Lys Ala Gly Thr Lys Gly His Pro Tyr Gly Gly Asp Tyr His 
145                 150                 155                 160 


Met Pro Arg Leu His Lys Phe Val Thr Asp Ala Glu Pro Val Glu Met 
                165                 170                 175     


Thr Ser Tyr Met Asp Gly Arg Lys Tyr Ile Asp Gln Asn Asn Tyr Pro 
            180                 185                 190         


Asp Arg Val Arg Ile Gly Ala Gly Arg Gln Tyr Trp Arg Ser Asp Glu 
        195                 200                 205             


Asp Glu Pro Asn Asn Arg Glu Ser Ser Tyr His Ile Ala Ser Ala Tyr 
    210                 215                 220                 


Ser Trp Leu Val Gly Gly Asn Thr Phe Ala Gln Asn Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Thr Val Asn Leu Gly Ser Glu Lys Ile Lys His Ser Pro Tyr Gly 
                245                 250                 255     


Phe Leu Pro Thr Gly Gly Ser Phe Gly Asp Ser Gly Ser Pro Met Phe 
            260                 265                 270         


Ile Tyr Asp Ala Gln Lys Gln Lys Trp Leu Ile Asn Gly Val Leu Gln 
        275                 280                 285             


Thr Gly Asn Pro Tyr Ile Gly Lys Ser Asn Gly Phe Gln Leu Val Arg 
    290                 295                 300                 


Lys Asp Trp Phe Tyr Asp Glu Ile Phe Ala Gly Asp Thr His Ser Val 
305                 310                 315                 320 


Phe Tyr Glu Pro Arg Gln Asn Gly Lys Tyr Ser Phe Asn Asp Asp Asn 
                325                 330                 335     


Asn Gly Thr Gly Lys Ile Asn Ala Lys His Glu His Asn Ser Leu Pro 
            340                 345                 350         


Asn Arg Leu Lys Thr Arg Thr Val Gln Leu Phe Asn Val Ser Leu Ser 
        355                 360                 365             


Glu Thr Ala Arg Glu Pro Val Tyr His Ala Ala Gly Gly Val Asn Ser 
    370                 375                 380                 


Tyr Arg Pro Arg Leu Asn Asn Gly Glu Asn Ile Ser Phe Ile Asp Glu 
385                 390                 395                 400 


Gly Lys Gly Glu Leu Ile Leu Thr Ser Asn Ile Asn Gln Gly Ala Gly 
                405                 410                 415     


Gly Leu Tyr Phe Gln Gly Asp Phe Thr Val Ser Pro Glu Asn Asn Glu 
            420                 425                 430         


Thr Trp Gln Gly Ala Gly Val His Ile Ser Glu Asp Ser Thr Val Thr 
        435                 440                 445             


Trp Lys Val Asn Gly Val Ala Asn Asp Arg Leu Ser Lys Ile Gly Lys 
    450                 455                 460                 


Gly Thr Leu His Val Gln Ala Lys Gly Glu Asn Gln Gly Ser Ile Ser 
465                 470                 475                 480 


Val Gly Asp Gly Thr Val Ile Leu Asp Gln Gln Ala Asp Asp Lys Gly 
                485                 490                 495     


Lys Lys Gln Ala Phe Ser Glu Ile Gly Leu Val Ser Gly Arg Gly Thr 
            500                 505                 510         


Val Gln Leu Asn Ala Asp Asn Gln Phe Asn Pro Asp Lys Leu Tyr Phe 
        515                 520                 525             


Gly Phe Arg Gly Gly Arg Leu Asp Leu Asn Gly His Ser Leu Ser Phe 
    530                 535                 540                 


His Arg Ile Gln Asn Thr Asp Glu Gly Ala Met Ile Val Asn His Asn 
545                 550                 555                 560 


Gln Asp Lys Glu Ser Thr Val Thr Ile Thr Gly Asn Lys Asp Ile Ala 
                565                 570                 575     


Thr Thr Gly Asn Asn Asn Ser Leu Asp Ser Lys Lys Glu Ile Ala Tyr 
            580                 585                 590         


Asn Gly Trp Phe Gly Glu Lys Asp Thr Thr Lys Thr Asn Gly Arg Leu 
        595                 600                 605             


Asn Leu Val Tyr Gln Pro Ala Ala Glu Asp Arg Thr Leu Leu Leu Ser 
    610                 615                 620                 


Gly Gly Thr Asn Leu Asn Gly Asn Ile Thr Gln Thr Asn Gly Lys Leu 
625                 630                 635                 640 


Phe Phe Ser Gly Arg Pro Thr Pro His Ala Tyr Asn His Leu Asn Asp 
                645                 650                 655     


His Trp Ser Gln Lys Glu Gly Ile Pro Arg Gly Glu Ile Val Trp Asp 
            660                 665                 670         


Asn Asp Trp Ile Asn Arg Thr Phe Lys Ala Glu Asn Phe Gln Ile Lys 
        675                 680                 685             


Gly Gly Gln Ala Val Val Ser Arg Asn Val Ala Lys Val Lys Gly Asp 
    690                 695                 700                 


Trp His Leu Ser Asn His Ala Gln Ala Val Phe Gly Val Ala Pro His 
705                 710                 715                 720 


Gln Ser His Thr Ile Cys Thr Arg Ser Asp Trp Thr Gly Leu Thr Asn 
                725                 730                 735     


Cys Val Glu Lys Thr Ile Thr Asp Asp Lys Val Ile Ala Ser Leu Thr 
            740                 745                 750         


Lys Thr Asp Ile Ser Gly Asn Val Asp Leu Ala Asp His Ala His Leu 
        755                 760                 765             


Asn Leu Thr Gly Leu Ala Thr Leu Asn Gly Asn Leu Ser Ala Asn Gly 
    770                 775                 780                 


Asp Thr Arg Tyr Thr Val Ser His Asn Ala Thr Gln Asn Gly Asn Leu 
785                 790                 795                 800 


Ser Leu Val Gly Asn Ala Gln Ala Thr Phe Asn Gln Ala Thr Leu Asn 
                805                 810                 815     


Gly Asn Thr Ser Ala Ser Gly Asn Ala Ser Phe Asn Leu Ser Asp His 
            820                 825                 830         


Ala Val Gln Asn Gly Ser Leu Thr Leu Ser Gly Asn Ala Lys Ala Asn 
        835                 840                 845             


Val Ser His Ser Ala Leu Asn Gly Asn Val Ser Leu Ala Asp Lys Ala 
    850                 855                 860                 


Val Phe His Phe Glu Ser Ser Arg Phe Thr Gly Gln Ile Ser Gly Gly 
865                 870                 875                 880 


Lys Asp Thr Ala Leu His Leu Lys Asp Ser Glu Trp Thr Leu Pro Ser 
                885                 890                 895     


Gly Thr Glu Leu Gly Asn Leu Asn Leu Asp Asn Ala Thr Ile Thr Leu 
            900                 905                 910         


Asn Ser Ala Tyr Arg His Asp Ala Ala Gly Ala Gln Thr Gly Ser Ala 
        915                 920                 925             


Thr Asp Ala Pro Arg Arg Arg Ser Arg Arg Ser Arg Arg Ser Leu Leu 
    930                 935                 940                 


Ser Val Thr Pro Pro Thr Ser Val Glu Ser Arg Phe Asn Thr Leu Thr 
945                 950                 955                 960 


Val Asn Gly Lys Leu Asn Gly Gln Gly Thr Phe Arg Phe Met Ser Glu 
                965                 970                 975     


Leu Phe Gly Tyr Arg Ser Asp Lys Leu Lys Leu Ala Glu Ser Ser Glu 
            980                 985                 990         


Gly Thr Tyr Thr Leu Ala Val Asn  Asn Thr Gly Asn Glu  Pro Ala Ser 
        995                 1000                 1005             


Leu Glu  Gln Leu Thr Val Val  Glu Gly Lys Asp Asn  Lys Pro Leu 
    1010                 1015                 1020             


Ser Glu  Asn Leu Asn Phe Thr  Leu Gln Asn Glu His  Val Asp Ala 
    1025                 1030                 1035             


Gly Ala  Trp Arg Tyr Gln Leu  Ile Arg Lys Asp Gly  Glu Phe Arg 
    1040                 1045                 1050             


Leu His  Asn Pro Val Lys Glu  Gln Glu Leu Ser Asp  Lys Leu Gly 
    1055                 1060                 1065             


Lys Ala  Glu Ala Lys Lys Gln  Ala Glu Lys Asp Asn  Ala Gln Ser 
    1070                 1075                 1080             


Leu Asp  Ala Leu Ile Ala Ala  Gly Arg Asp Ala Val  Glu Lys Thr 
    1085                 1090                 1095             


Glu Ser  Val Ala Glu Pro Ala  Arg Gln Ala Gly Gly  Glu Asn Val 
    1100                 1105                 1110             


Gly Ile  Met Gln Ala Glu Glu  Glu Lys Lys Arg Val  Gln Ala Asp 
    1115                 1120                 1125             


Lys Asp  Thr Ala Leu Ala Lys  Gln Arg Glu Ala Glu  Thr Arg Pro 
    1130                 1135                 1140             


Ala Thr  Thr Ala Phe Pro Arg  Ala Arg Arg Ala Arg  Arg Asp Leu 
    1145                 1150                 1155             


Pro Gln  Leu Gln Pro Gln Pro  Gln Pro Gln Pro Gln  Arg Asp Leu 
    1160                 1165                 1170             


Ile Ser  Arg Tyr Ala Asn Ser  Gly Leu Ser Glu Phe  Ser Ala Thr 
    1175                 1180                 1185             


Leu Asn  Ser Val Phe Ala Val  Gln Asp Glu Leu Asp  Arg Val Phe 
    1190                 1195                 1200             


Ala Glu  Asp Arg Arg Asn Ala  Val Trp Thr Ser Gly  Ile Arg Asp 
    1205                 1210                 1215             


Thr Lys  His Tyr Arg Ser Gln  Asp Phe Arg Ala Tyr  Arg Gln Gln 
    1220                 1225                 1230             


Thr Asp  Leu Arg Gln Ile Gly  Met Gln Lys Asn Leu  Gly Ser Gly 
    1235                 1240                 1245             


Arg Val  Gly Ile Leu Phe Ser  His Asn Arg Thr Glu  Asn Thr Phe 
    1250                 1255                 1260             


Asp Asp  Gly Ile Gly Asn Ser  Ala Arg Leu Ala His  Gly Ala Val 
    1265                 1270                 1275             


Phe Gly  Gln Tyr Gly Ile Asp  Arg Phe Tyr Ile Gly  Ile Ser Ala 
    1280                 1285                 1290             


Gly Ala  Gly Phe Ser Ser Gly  Ser Leu Ser Asp Gly  Ile Gly Gly 
    1295                 1300                 1305             


Lys Ile  Arg Arg Arg Val Leu  His Tyr Gly Ile Gln  Ala Arg Tyr 
    1310                 1315                 1320             


Arg Ala  Gly Phe Gly Gly Phe  Gly Ile Glu Pro His  Ile Gly Ala 
    1325                 1330                 1335             


Thr Arg  Tyr Phe Val Gln Lys  Ala Asp Tyr Arg Tyr  Glu Asn Val 
    1340                 1345                 1350             


Asn Ile  Ala Thr Pro Gly Leu  Ala Phe Asn Arg Tyr  Arg Ala Gly 
    1355                 1360                 1365             


Ile Lys  Ala Asp Tyr Ser Phe  Lys Pro Ala Gln His  Ile Ser Ile 
    1370                 1375                 1380             


Thr Pro  Tyr Leu Ser Leu Ser  Tyr Thr Asp Ala Ala  Ser Gly Lys 
    1385                 1390                 1395             


Val Arg  Thr Arg Val Asn Thr  Ala Val Leu Ala Gln  Asp Phe Gly 
    1400                 1405                 1410             


Lys Thr  Arg Ser Ala Glu Trp  Gly Val Asn Ala Glu  Ile Lys Gly 
    1415                 1420                 1425             


Phe Thr  Leu Ser Leu His Ala  Ala Ala Ala Lys Gly  Pro Gln Leu 
    1430                 1435                 1440             


Glu Ala  Gln His Ser Ala Gly  Ile Lys Leu Gly Tyr  Arg Trp 
    1445                 1450                 1455         


<210>  7
<211>  327
<212>  PRT
<213>  Neisseria meningitidis

<400>  7

Ala Thr Asn Asp Asp Asp Val Lys Lys Ala Ala Thr Val Ala Ile Ala 
1               5                   10                  15      


Ala Ala Tyr Asn Asn Gly Gln Glu Ile Asn Gly Phe Lys Ala Gly Glu 
            20                  25                  30          


Thr Ile Tyr Asp Ile Asp Glu Asp Gly Thr Ile Thr Lys Lys Asp Ala 
        35                  40                  45              


Thr Ala Ala Asp Val Glu Ala Asp Asp Phe Lys Gly Leu Gly Leu Lys 
    50                  55                  60                  


Lys Val Val Thr Asn Leu Thr Lys Thr Val Asn Glu Asn Lys Gln Asn 
65                  70                  75                  80  


Val Asp Ala Lys Val Lys Ala Ala Glu Ser Glu Ile Glu Lys Leu Thr 
                85                  90                  95      


Thr Lys Leu Ala Asp Thr Asp Ala Ala Leu Ala Asp Thr Asp Ala Ala 
            100                 105                 110         


Leu Asp Ala Thr Thr Asn Ala Leu Asn Lys Leu Gly Glu Asn Ile Thr 
        115                 120                 125             


Thr Phe Ala Glu Glu Thr Lys Thr Asn Ile Val Lys Ile Asp Glu Lys 
    130                 135                 140                 


Leu Glu Ala Val Ala Asp Thr Val Asp Lys His Ala Glu Ala Phe Asn 
145                 150                 155                 160 


Asp Ile Ala Asp Ser Leu Asp Glu Thr Asn Thr Lys Ala Asp Glu Ala 
                165                 170                 175     


Val Lys Thr Ala Asn Glu Ala Lys Gln Thr Ala Glu Glu Thr Lys Gln 
            180                 185                 190         


Asn Val Asp Ala Lys Val Lys Ala Ala Glu Thr Ala Ala Gly Lys Ala 
        195                 200                 205             


Glu Ala Ala Ala Gly Thr Ala Asn Thr Ala Ala Asp Lys Ala Glu Ala 
    210                 215                 220                 


Val Ala Ala Lys Val Thr Asp Ile Lys Ala Asp Ile Ala Thr Asn Lys 
225                 230                 235                 240 


Asp Asn Ile Ala Lys Lys Ala Asn Ser Ala Asp Val Tyr Thr Arg Glu 
                245                 250                 255     


Glu Ser Asp Ser Lys Phe Val Arg Ile Asp Gly Leu Asn Ala Thr Thr 
            260                 265                 270         


Glu Lys Leu Asp Thr Arg Leu Ala Ser Ala Glu Lys Ser Ile Ala Asp 
        275                 280                 285             


His Asp Thr Arg Leu Asn Gly Leu Asp Lys Thr Val Ser Asp Leu Arg 
    290                 295                 300                 


Lys Glu Thr Arg Gln Gly Leu Ala Glu Gln Ala Ala Leu Ser Gly Leu 
305                 310                 315                 320 


Phe Gln Pro Tyr Asn Val Gly 
                325         


<210>  8
<211>  248
<212>  PRT
<213>  Neisseria meningitidis

<400>  8

Val Ala Ala Asp Ile Gly Ala Gly Leu Ala Asp Ala Leu Thr Ala Pro 
1               5                   10                  15      


Leu Asp His Lys Asp Lys Gly Leu Gln Ser Leu Thr Leu Asp Gln Ser 
            20                  25                  30          


Val Arg Lys Asn Glu Lys Leu Lys Leu Ala Ala Gln Gly Ala Glu Lys 
        35                  40                  45              


Thr Tyr Gly Asn Gly Asp Ser Leu Asn Thr Gly Lys Leu Lys Asn Asp 
    50                  55                  60                  


Lys Val Ser Arg Phe Asp Phe Ile Arg Gln Ile Glu Val Asp Gly Gln 
65                  70                  75                  80  


Leu Ile Thr Leu Glu Ser Gly Glu Phe Gln Val Tyr Lys Gln Ser His 
                85                  90                  95      


Ser Ala Leu Thr Ala Phe Gln Thr Glu Gln Ile Gln Asp Ser Glu His 
            100                 105                 110         


Ser Gly Lys Met Val Ala Lys Arg Gln Phe Arg Ile Gly Asp Ile Ala 
        115                 120                 125             


Gly Glu His Thr Ser Phe Asp Lys Leu Pro Glu Gly Gly Arg Ala Thr 
    130                 135                 140                 


Tyr Arg Gly Thr Ala Phe Gly Ser Asp Asp Ala Gly Gly Lys Leu Thr 
145                 150                 155                 160 


Tyr Thr Ile Asp Phe Ala Ala Lys Gln Gly Asn Gly Lys Ile Glu His 
                165                 170                 175     


Leu Lys Ser Pro Glu Leu Asn Val Asp Leu Ala Ala Ala Asp Ile Lys 
            180                 185                 190         


Pro Asp Gly Lys Arg His Ala Val Ile Ser Gly Ser Val Leu Tyr Asn 
        195                 200                 205             


Gln Ala Glu Lys Gly Ser Tyr Ser Leu Gly Ile Phe Gly Gly Lys Ala 
    210                 215                 220                 


Gln Glu Val Ala Gly Ser Ala Glu Val Lys Thr Val Asn Gly Ile Arg 
225                 230                 235                 240 


His Ile Gly Leu Ala Ala Lys Gln 
                245             


<210>  9
<211>  250
<212>  PRT
<213>  Neisseria meningitidis

<400>  9

Val Ala Ala Asp Ile Gly Thr Gly Leu Ala Asp Ala Leu Thr Ala Pro 
1               5                   10                  15      


Leu Asp His Lys Asp Lys Gly Leu Lys Ser Leu Thr Leu Glu Asp Ser 
            20                  25                  30          


Ile Pro Gln Asn Gly Thr Leu Thr Leu Ser Ala Gln Gly Ala Glu Lys 
        35                  40                  45              


Thr Phe Lys Ala Gly Asp Lys Asp Asn Ser Leu Asn Thr Gly Lys Leu 
    50                  55                  60                  


Lys Asn Asp Lys Ile Ser Arg Phe Asp Phe Val Gln Lys Ile Glu Val 
65                  70                  75                  80  


Asp Gly Gln Thr Ile Thr Leu Ala Ser Gly Glu Phe Gln Ile Tyr Lys 
                85                  90                  95      


Gln Asn His Ser Ala Val Val Ala Leu Gln Ile Glu Lys Ile Asn Asn 
            100                 105                 110         


Pro Asp Lys Thr Asp Ser Leu Ile Asn Gln Arg Ser Phe Leu Val Ser 
        115                 120                 125             


Gly Leu Gly Gly Glu His Thr Ala Phe Asn Gln Leu Pro Gly Gly Lys 
    130                 135                 140                 


Ala Glu Tyr His Gly Lys Ala Phe Ser Ser Asp Asp Pro Asn Gly Arg 
145                 150                 155                 160 


Leu His Tyr Ser Ile Asp Phe Thr Lys Lys Gln Gly Tyr Gly Arg Ile 
                165                 170                 175     


Glu His Leu Lys Thr Leu Glu Gln Asn Val Glu Leu Ala Ala Ala Glu 
            180                 185                 190         


Leu Lys Ala Asp Glu Lys Ser His Ala Val Ile Leu Gly Asp Thr Arg 
        195                 200                 205             


Tyr Gly Ser Glu Glu Lys Gly Thr Tyr His Leu Ala Leu Phe Gly Asp 
    210                 215                 220                 


Arg Ala Gln Glu Ile Ala Gly Ser Ala Thr Val Lys Ile Gly Glu Lys 
225                 230                 235                 240 


Val His Glu Ile Gly Ile Ala Gly Lys Gln 
                245                 250 


<210>  10
<211>  171
<212>  PRT
<213>  P.falciparum

<400>  10

Lys Val Thr Val Asp Thr Val Cys Lys Arg Gly Phe Leu Ile Gln Met 
1               5                   10                  15      


Ser Gly His Leu Glu Cys Lys Cys Glu Asn Asp Leu Val Leu Val Asn 
            20                  25                  30          


Glu Glu Thr Cys Glu Glu Lys Val Leu Lys Cys Asp Glu Lys Thr Val 
        35                  40                  45              


Asn Lys Pro Cys Gly Asp Phe Ser Lys Cys Ile Lys Ile Asp Gly Asn 
    50                  55                  60                  


Pro Val Ser Tyr Ala Cys Lys Cys Asn Leu Gly Tyr Asp Met Val Asn 
65                  70                  75                  80  


Asn Val Cys Ile Pro Asn Glu Cys Lys Gln Val Thr Cys Gly Asn Gly 
                85                  90                  95      


Lys Cys Ile Leu Asp Thr Ser Asn Pro Val Lys Thr Gly Val Cys Ser 
            100                 105                 110         


Cys Asn Ile Gly Lys Val Pro Asn Val Gln Asp Gln Asn Lys Cys Ser 
        115                 120                 125             


Lys Asp Gly Glu Thr Lys Cys Ser Leu Lys Cys Leu Lys Glu Gln Glu 
    130                 135                 140                 


Thr Cys Lys Ala Val Asp Gly Ile Tyr Lys Cys Asp Cys Lys Asp Gly 
145                 150                 155                 160 


Phe Ile Ile Asp Gln Glu Ser Ser Ile Cys Thr 
                165                 170     


<210>  11
<211>  630
<212>  PRT
<213>  Artificial

<220>
<223>  pfs48/45-GURLP fusion protein

<400>  11

Ala Glu Arg Ser Thr Ser Glu Asn Arg Asn Lys Arg Ile Gly Gly Pro 
1               5                   10                  15      


Lys Leu Arg Gly Asn Val Thr Ser Asn Ile Lys Phe Pro Ser Asp Asn 
            20                  25                  30          


Lys Gly Lys Ile Ile Arg Gly Ser Asn Asp Lys Leu Asn Lys Asn Ser 
        35                  40                  45              


Glu Asp Val Leu Glu Gln Ser Glu Lys Ser Leu Val Ser Glu Asn Val 
    50                  55                  60                  


Pro Ser Gly Leu Asp Ile Asp Asp Ile Pro Lys Glu Ser Ile Phe Ile 
65                  70                  75                  80  


Gln Glu Asp Gln Glu Gly Gln Thr His Ser Glu Leu Asn Pro Glu Thr 
                85                  90                  95      


Ser Glu His Ser Lys Asp Leu Asn Asn Asn Gly Ser Lys Asn Glu Ser 
            100                 105                 110         


Ser Asp Ile Ile Ser Glu Asn Asn Lys Ser Asn Lys Val Gln Asn His 
        115                 120                 125             


Phe Glu Ser Leu Ser Asp Leu Glu Leu Leu Glu Asn Ser Ser Gln Asp 
    130                 135                 140                 


Asn Leu Asp Lys Asp Thr Ile Ser Thr Glu Pro Phe Pro Asn Gln Lys 
145                 150                 155                 160 


His Lys Asp Leu Gln Gln Asp Leu Asn Asp Glu Pro Leu Glu Pro Phe 
                165                 170                 175     


Pro Thr Gln Ile His Lys Asp Tyr Lys Glu Lys Asn Leu Ile Asn Glu 
            180                 185                 190         


Glu Asp Ser Glu Pro Phe Pro Arg Gln Lys His Lys Lys Val Asp Asn 
        195                 200                 205             


His Asn Glu Glu Lys Asn Val Phe His Glu Asn Gly Ser Ala Asn Gly 
    210                 215                 220                 


Asn Gln Gly Ser Leu Lys Leu Lys Ser Phe Asp Glu His Leu Lys Asp 
225                 230                 235                 240 


Glu Lys Ile Glu Asn Glu Pro Leu Val His Glu Asn Leu Ser Ile Pro 
                245                 250                 255     


Asn Asp Pro Ile Glu Gln Ile Leu Asn Gln Pro Glu Gln Glu Thr Asn 
            260                 265                 270         


Ile Gln Glu Gln Leu Tyr Asn Glu Lys Gln Asn Val Glu Glu Lys Gln 
        275                 280                 285             


Asn Ser Gln Ile Pro Ser Leu Asp Leu Lys Glu Pro Thr Asn Glu Asp 
    290                 295                 300                 


Ile Leu Pro Asn His Asn Pro Leu Glu Asn Ile Lys Gln Ser Glu Ser 
305                 310                 315                 320 


Glu Ile Asn His Val Gln Asp His Ala Leu Pro Lys Glu Asn Ile Ile 
                325                 330                 335     


Asp Lys Leu Asp Asn Gln Lys Glu His Ile Asp Gln Ser Gln His Asn 
            340                 345                 350         


Ile Asn Val Leu Gln Glu Asn Asn Ile Asn Asn His Gln Leu Glu Pro 
        355                 360                 365             


Gln Glu Lys Pro Asn Ile Glu Ser Phe Glu Pro Lys Asn Ile Asp Ser 
    370                 375                 380                 


Glu Ile Ile Leu Pro Glu Asn Val Glu Thr Glu Glu Ile Ile Asp Asp 
385                 390                 395                 400 


Val Pro Ser Pro Lys His Ser Asn His Glu Thr Phe Glu Glu Glu Thr 
                405                 410                 415     


Ser Glu Ser Glu His Glu Glu Ala Val Ser Glu Lys Asn Ala His Glu 
            420                 425                 430         


Thr Val Glu His Glu Glu Thr Val Ser Gln Glu Ser Asn Pro Glu Lys 
        435                 440                 445             


Ala Asp Asn Asp Gly Asn Val Ser Gln Asn Ser Asn Asn Glu Leu Asn 
    450                 455                 460                 


Glu Asn Glu Phe Val Glu Ser Glu Lys Ser Glu His Glu Ala Arg Ser 
465                 470                 475                 480 


Lys Pro Lys Tyr Glu Lys Lys Val Ile His Gly Cys Asn Phe Ser Ser 
                485                 490                 495     


Asn Val Ser Ser Lys His Thr Phe Thr Asp Ser Leu Asp Ile Ser Leu 
            500                 505                 510         


Val Asp Asp Ser Ala His Ile Ser Cys Asn Val His Leu Ser Glu Pro 
        515                 520                 525             


Lys Tyr Asn His Leu Val Gly Leu Asn Cys Pro Gly Asp Ile Ile Pro 
    530                 535                 540                 


Asp Cys Phe Phe Gln Val Tyr Gln Pro Glu Ser Glu Glu Leu Glu Pro 
545                 550                 555                 560 


Ser Asn Ile Val Tyr Leu Asp Ser Gln Ile Asn Ile Gly Asp Ile Glu 
                565                 570                 575     


Tyr Tyr Glu Asp Ala Glu Gly Asp Asp Lys Ile Lys Leu Phe Gly Ile 
            580                 585                 590         


Val Gly Ser Ile Pro Lys Thr Thr Ser Phe Thr Cys Ile Cys Lys Lys 
        595                 600                 605             


Asp Lys Lys Ser Ala Tyr Met Thr Val Thr Ile Asp Ser Ala Arg Ser 
    610                 615                 620                 


His His His His His His 
625                 630 


<210>  12
<211>  394
<212>  PRT
<213>  circumsporozoite

<400>  12

Met Leu Phe Gln Glu Tyr Gln Cys Tyr Gly Ser Ser Ser Asn Thr Arg 
1               5                   10                  15      


Val Leu Asn Glu Leu Asn Tyr Asp Asn Ala Gly Thr Asn Leu Tyr Asn 
            20                  25                  30          


Glu Leu Glu Met Asn Tyr Tyr Gly Lys Gln Glu Asn Trp Tyr Ser Leu 
        35                  40                  45              


Lys Lys Asn Ser Arg Ser Leu Gly Glu Asn Asp Asp Gly Asn Asn Asn 
    50                  55                  60                  


Asn Gly Asp Asn Gly Arg Glu Gly Lys Asp Glu Asp Lys Arg Asp Gly 
65                  70                  75                  80  


Asn Asn Glu Asp Asn Glu Lys Leu Arg Lys Pro Lys His Lys Lys Leu 
                85                  90                  95      


Lys Gln Pro Gly Asp Gly Asn Pro Asp Pro Asn Ala Asn Pro Asn Val 
            100                 105                 110         


Asp Pro Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro Asn Val 
        115                 120                 125             


Asp Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
    130                 135                 140                 


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
145                 150                 155                 160 


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
                165                 170                 175     


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Val 
            180                 185                 190         


Asp Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
        195                 200                 205             


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
    210                 215                 220                 


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
225                 230                 235                 240 


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
                245                 250                 255     


Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Lys 
            260                 265                 270         


Asn Asn Gln Gly Asn Gly Gln Gly His Asn Met Pro Asn Asp Pro Asn 
        275                 280                 285             


Arg Asn Val Asp Glu Asn Ala Asn Ala Asn Asn Ala Val Lys Asn Asn 
    290                 295                 300                 


Asn Asn Glu Glu Pro Ser Asp Lys His Ile Glu Lys Tyr Leu Lys Lys 
305                 310                 315                 320 


Ile Gln Asn Ser Leu Ser Thr Glu Trp Ser Pro Cys Ser Val Thr Cys 
                325                 330                 335     


Gly Asn Gly Ile Gln Val Arg Ile Lys Pro Gly Ser Ala Asn Lys Pro 
            340                 345                 350         


Lys Asp Glu Leu Asp Tyr Glu Asn Asp Ile Glu Lys Lys Ile Cys Lys 
        355                 360                 365             


Met Glu Lys Cys Ser Ser Val Phe Asn Val Val Asn Ser Ser Ile Gly 
    370                 375                 380                 


Leu Ile Leu Glu His His His His His His 
385                 390                 


<210>  13
<211>  12
<212>  PRT
<213>  circumsporozoite

<400>  13

Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
1               5                   10          


<210>  14
<211>  134
<212>  PRT
<213>  E. coli

<400>  14

Gln Asp Gln Arg Tyr Ile Ser Ile Arg Asn Thr Asp Thr Ile Trp Leu 
1               5                   10                  15      


Pro Gly Asn Ile Cys Ala Tyr Gln Phe Arg Leu Asp Asn Gly Gly Asn 
            20                  25                  30          


Asp Glu Gly Phe Gly Pro Leu Thr Ile Thr Leu Gln Leu Lys Asp Lys 
        35                  40                  45              


Tyr Gly Gln Thr Leu Val Thr Arg Lys Met Glu Thr Glu Ala Phe Gly 
    50                  55                  60                  


Asp Ser Asn Ala Thr Arg Thr Thr Asp Ala Phe Leu Glu Thr Glu Cys 
65                  70                  75                  80  


Val Glu Asn Val Ala Thr Thr Glu Ile Ile Lys Ala Thr Glu Glu Ser 
                85                  90                  95      


Asn Gly His Arg Val Ser Leu Pro Leu Ser Val Phe Asp Pro Gln Asp 
            100                 105                 110         


Tyr His Pro Leu Leu Ile Thr Val Ser Gly Lys Asn Val Asn Leu Glu 
        115                 120                 125             


His His His His His His 
    130                 


<210>  15
<211>  1487
<212>  PRT
<213>  E.coli

<400>  15

Asp Thr Pro Ser Val Asp Ser Gly Ser Gly Thr Leu Pro Glu Val Lys 
1               5                   10                  15      


Pro Asp Pro Thr Pro Thr Pro Glu Pro Thr Pro Glu Pro Thr Pro Asp 
            20                  25                  30          


Pro Glu Pro Thr Pro Asp Pro Thr Pro Asp Pro Glu Pro Thr Pro Glu 
        35                  40                  45              


Pro Glu Pro Glu Pro Val Pro Thr Lys Thr Gly Tyr Leu Thr Leu Gly 
    50                  55                  60                  


Gly Ser Gln Arg Val Thr Gly Ala Thr Cys Asn Gly Glu Ser Ser Asp 
65                  70                  75                  80  


Gly Phe Thr Phe Thr Pro Gly Asn Thr Val Ser Cys Val Val Gly Ser 
                85                  90                  95      


Thr Thr Ile Ala Thr Phe Asn Thr Gln Ser Glu Ala Ala Arg Ser Leu 
            100                 105                 110         


Arg Ala Val Asp Lys Val Ser Phe Ser Leu Glu Asp Ala Gln Glu Leu 
        115                 120                 125             


Ala Asn Ser Glu Asn Lys Lys Thr Asn Ala Ile Ser Leu Val Thr Ser 
    130                 135                 140                 


Ser Asp Ser Cys Pro Ala Asp Ala Glu Gln Leu Cys Leu Thr Phe Ser 
145                 150                 155                 160 


Ser Val Val Asp Arg Ala Arg Phe Glu Lys Leu Tyr Lys Gln Ile Asp 
                165                 170                 175     


Leu Ala Thr Asp Asn Phe Ser Lys Leu Val Asn Glu Glu Val Glu Asn 
            180                 185                 190         


Asn Ala Ala Thr Asp Lys Ala Pro Ser Thr His Thr Ser Thr Val Val 
        195                 200                 205             


Pro Val Thr Thr Glu Gly Thr Lys Pro Asp Leu Asn Ala Ser Phe Val 
    210                 215                 220                 


Ser Ala Asn Ala Glu Gln Phe Tyr Gln Tyr Gln Pro Thr Glu Ile Ile 
225                 230                 235                 240 


Leu Ser Glu Gly Gln Leu Val Asp Ser Leu Gly Asn Gly Val Ala Gly 
                245                 250                 255     


Val Asp Tyr Tyr Thr Asn Ser Gly Arg Gly Val Thr Asp Glu Asn Gly 
            260                 265                 270         


Lys Phe Ser Phe Ser Trp Gly Glu Thr Ile Ser Phe Gly Ile Asp Thr 
        275                 280                 285             


Phe Glu Leu Gly Ser Val Arg Gly Asn Lys Ser Thr Ile Ala Leu Thr 
    290                 295                 300                 


Glu Leu Gly Asp Glu Val Arg Gly Ala Asn Ile Asp Gln Leu Ile His 
305                 310                 315                 320 


Arg Tyr Ser Thr Thr Gly Gln Asn Asn Thr Arg Val Val Pro Asp Asp 
                325                 330                 335     


Val Arg Lys Val Phe Ala Glu Tyr Pro Asn Val Ile Asn Glu Ile Ile 
            340                 345                 350         


Asn Leu Ser Leu Ser Asn Gly Ala Thr Leu Asp Glu Gly Asp Gln Asn 
        355                 360                 365             


Val Val Leu Pro Asn Glu Phe Ile Glu Gln Phe Lys Thr Gly Gln Ala 
    370                 375                 380                 


Lys Glu Ile Asp Thr Ala Ile Cys Ala Lys Thr Asp Gly Cys Asn Glu 
385                 390                 395                 400 


Ala Arg Trp Phe Ser Leu Thr Thr Arg Asn Val Asn Asp Gly Gln Ile 
                405                 410                 415     


Gln Gly Val Ile Asn Lys Leu Trp Gly Val Asp Thr Asn Tyr Gln Ser 
            420                 425                 430         


Val Ser Lys Phe His Val Phe His Asp Ser Thr Asn Phe Tyr Gly Ser 
        435                 440                 445             


Thr Gly Asn Ala Arg Gly Gln Ala Val Val Asn Ile Ser Asn Ser Ala 
    450                 455                 460                 


Phe Pro Ile Leu Met Ala Arg Asn Asp Lys Asn Tyr Trp Leu Ala Phe 
465                 470                 475                 480 


Gly Glu Lys Arg Ala Trp Asp Lys Asn Glu Leu Ala Tyr Ile Thr Glu 
                485                 490                 495     


Ala Pro Ser Ile Val Gln Pro Glu Asn Val Thr Arg Asp Thr Ala Thr 
            500                 505                 510         


Phe Asn Leu Pro Phe Ile Ser Leu Gly Gln Val Gly Glu Gly Lys Leu 
        515                 520                 525             


Met Val Ile Gly Asn Pro His Tyr Asn Ser Ile Leu Arg Cys Pro Asn 
    530                 535                 540                 


Gly Tyr Ser Trp Gly Gly Gly Val Asn Ser Lys Gly Glu Cys Thr Leu 
545                 550                 555                 560 


Ser Gly Asp Ser Asp Asp Met Lys His Phe Met Gln Asn Val Leu Arg 
                565                 570                 575     


Tyr Leu Ser Asn Asp Ile Trp Gln Pro Asn Thr Lys Ser Ile Met Thr 
            580                 585                 590         


Val Gly Thr Asn Leu Glu Asn Val Tyr Phe Lys Lys Ala Gly Gln Val 
        595                 600                 605             


Leu Gly Asn Ser Ala Pro Phe Ala Phe His Glu Asp Phe Thr Gly Ile 
    610                 615                 620                 


Thr Val Lys Gln Leu Thr Ser Tyr Gly Asp Leu Asn Pro Glu Glu Ile 
625                 630                 635                 640 


Pro Leu Leu Ile Leu Asn Gly Phe Glu Tyr Val Thr Gln Trp Ser Gly 
                645                 650                 655     


Asp Pro Tyr Ala Val Pro Leu Arg Ala Asp Thr Ser Lys Pro Lys Leu 
            660                 665                 670         


Thr Gln Gln Asp Val Thr Asp Leu Ile Ala Tyr Leu Asn Lys Gly Gly 
        675                 680                 685             


Ser Val Leu Ile Met Glu Asn Val Met Ser Asn Leu Lys Glu Glu Ser 
    690                 695                 700                 


Ala Ser Ser Phe Val Arg Leu Leu Asp Ala Ala Gly Leu Ser Met Ala 
705                 710                 715                 720 


Leu Asn Lys Ser Val Val Asn Asn Asp Pro Gln Gly Tyr Pro Asp Arg 
                725                 730                 735     


Val Arg Gln Arg Arg Ala Thr Gly Ile Trp Val Tyr Glu Arg Tyr Pro 
            740                 745                 750         


Ala Ala Asp Gly Ala Gln Pro Pro Tyr Thr Ile Asp Pro Asn Thr Gly 
        755                 760                 765             


Glu Val Thr Trp Lys Tyr Gln Gln Asp Asn Lys Pro Asp Asp Lys Pro 
    770                 775                 780                 


Lys Leu Glu Val Ala Ser Trp Gln Glu Glu Val Glu Gly Lys Gln Val 
785                 790                 795                 800 


Thr Arg Tyr Ala Phe Ile Asp Glu Ala Glu Tyr Thr Thr Glu Glu Ser 
                805                 810                 815     


Leu Glu Ala Ala Lys Ala Lys Ile Phe Glu Lys Phe Pro Gly Leu Gln 
            820                 825                 830         


Glu Cys Lys Asp Ser Thr Tyr His Tyr Glu Ile Asn Cys Leu Glu Arg 
        835                 840                 845             


Arg Pro Gly Thr Asp Val Pro Val Thr Gly Gly Met Tyr Val Pro Arg 
    850                 855                 860                 


Tyr Thr Gln Leu Asn Leu Asp Ala Asp Thr Ala Lys Ala Met Val Gln 
865                 870                 875                 880 


Ala Ala Asp Leu Gly Thr Asn Ile Gln Arg Leu Tyr Gln His Glu Leu 
                885                 890                 895     


Tyr Phe Arg Thr Lys Gly Ser Lys Gly Glu Arg Leu Asn Ser Val Asp 
            900                 905                 910         


Leu Glu Arg Leu Tyr Gln Asn Met Ser Val Trp Leu Trp Asn Asp Thr 
        915                 920                 925             


Lys Tyr Arg Tyr Glu Glu Gly Lys Glu Asp Glu Leu Gly Phe Lys Thr 
    930                 935                 940                 


Phe Thr Glu Phe Leu Asn Cys Tyr Ala Asn Asp Ala Tyr Ala Gly Gly 
945                 950                 955                 960 


Thr Lys Cys Ser Ala Asp Leu Lys Lys Ser Leu Val Asp Asn Asn Met 
                965                 970                 975     


Ile Tyr Gly Asp Gly Ser Ser Lys Ala Gly Met Met Asn Pro Ser Tyr 
            980                 985                 990         


Pro Leu Asn Tyr Met Glu Lys Pro  Leu Thr Arg Leu Met  Leu Gly Arg 
        995                 1000                 1005             


Ser Trp  Trp Asp Leu Asn Ile  Lys Val Asp Val Glu  Lys Tyr Pro 
    1010                 1015                 1020             


Gly Ser  Val Ser Ala Lys Gly  Glu Ser Val Thr Glu  Asn Ile Ser 
    1025                 1030                 1035             


Leu Tyr  Ser Asn Pro Thr Lys  Trp Phe Ala Gly Asn  Met Gln Ser 
    1040                 1045                 1050             


Thr Gly  Leu Trp Ala Pro Ala  Gln Gln Asp Val Thr  Ile Lys Ser 
    1055                 1060                 1065             


Ser Ala  Ser Val Pro Val Thr  Val Thr Val Ala Leu  Ala Asp Asp 
    1070                 1075                 1080             


Leu Thr  Gly Arg Glu Lys His  Glu Val Ala Leu Asn  Arg Pro Pro 
    1085                 1090                 1095             


Arg Val  Thr Lys Thr Tyr Thr  Leu Glu Ala Asn Gly  Glu Val Thr 
    1100                 1105                 1110             


Phe Lys  Val Pro Tyr Gly Gly  Leu Ile Tyr Ile Lys  Gly Asp Ser 
    1115                 1120                 1125             


Lys Asp  Asp Val Ser Ala Asn  Phe Thr Phe Thr Gly  Val Val Lys 
    1130                 1135                 1140             


Ala Pro  Phe Tyr Lys Asp Gly  Glu Trp Lys Asn Asp  Leu Asp Ser 
    1145                 1150                 1155             


Pro Ala  Pro Leu Gly Glu Leu  Glu Ser Ala Ser Phe  Val Tyr Thr 
    1160                 1165                 1170             


Thr Pro  Lys Lys Asn Leu Glu  Ala Ser Asn Phe Thr  Gly Gly Val 
    1175                 1180                 1185             


Ala Glu  Phe Ala Lys Asp Leu  Asp Thr Phe Ala Ser  Ser Met Asn 
    1190                 1195                 1200             


Asp Phe  Tyr Gly Arg Asn Asp  Glu Asp Gly Lys His  Arg Met Phe 
    1205                 1210                 1215             


Thr Tyr  Lys Asn Leu Thr Gly  His Lys His Arg Phe  Thr Asn Asp 
    1220                 1225                 1230             


Val Gln  Ile Ser Ile Gly Asp  Ala His Ser Gly Tyr  Pro Val Met 
    1235                 1240                 1245             


Asn Ser  Ser Phe Ser Thr Asn  Ser Thr Thr Leu Pro  Thr Thr Pro 
    1250                 1255                 1260             


Leu Asn  Asp Trp Leu Ile Trp  His Glu Val Gly His  Asn Ala Ala 
    1265                 1270                 1275             


Glu Thr  Pro Leu Asn Val Pro  Gly Ala Thr Glu Val  Ala Asn Asn 
    1280                 1285                 1290             


Val Leu  Ala Leu Tyr Met Gln  Asp Arg Tyr Leu Gly  Lys Met Asn 
    1295                 1300                 1305             


Arg Val  Ala Asp Asp Ile Thr  Val Ala Pro Glu Tyr  Leu Asp Glu 
    1310                 1315                 1320             


Ser Asn  Gly Gln Ala Trp Ala  Arg Gly Gly Ala Gly  Asp Arg Leu 
    1325                 1330                 1335             


Leu Met  Tyr Ala Gln Leu Lys  Glu Trp Ala Glu Glu  Asn Phe Asp 
    1340                 1345                 1350             


Ile Lys  Gln Trp Tyr Pro Asp  Gly Glu Leu Pro Lys  Phe Tyr Ser 
    1355                 1360                 1365             


Asp Arg  Lys Gly Met Lys Gly  Trp Asn Leu Phe Gln  Leu Met His 
    1370                 1375                 1380             


Arg Lys  Ala Arg Gly Asp Asp  Val Gly Asn Ser Thr  Phe Gly Gly 
    1385                 1390                 1395             


Lys Asn  Tyr Cys Ala Glu Ser  Asn Gly Asn Ala Ala  Asp Thr Leu 
    1400                 1405                 1410             


Met Leu  Cys Ala Ser Trp Val  Ala Gln Ala Asp Leu  Ser Glu Phe 
    1415                 1420                 1425             


Phe Lys  Lys Trp Asn Pro Gly  Ala Ser Ala Tyr Gln  Leu Pro Gly 
    1430                 1435                 1440             


Ala Thr  Glu Met Ser Phe Gln  Gly Gly Val Ser Ser  Ser Ala Tyr 
    1445                 1450                 1455             


Ser Thr  Leu Ala Ser Leu Lys  Leu Pro Lys Pro Glu  Lys Gly Pro 
    1460                 1465                 1470             


Glu Thr  Ile Asn Lys Val Thr  Glu His Lys Met Ser  Ala Glu 
    1475                 1480                 1485         


<210>  16
<211>  414
<212>  PRT
<213>  E.coli

<400>  16

Val Ala Asp Gly Gln Gln Ala Tyr Thr Leu Thr Leu Thr Ala Val Asp 
1               5                   10                  15      


Ser Glu Gly Asn Pro Val Thr Gly Glu Ala Ser Arg Leu Arg Leu Val 
            20                  25                  30          


Pro Gln Asp Thr Asn Gly Val Thr Val Gly Ala Ile Ser Glu Ile Lys 
        35                  40                  45              


Pro Gly Val Tyr Ser Ala Thr Val Ser Ser Thr Arg Ala Gly Asn Val 
    50                  55                  60                  


Val Val Arg Ala Phe Ser Glu Gln Tyr Gln Leu Gly Thr Leu Gln Gln 
65                  70                  75                  80  


Thr Leu Lys Phe Val Ala Gly Pro Leu Asp Ala Ala His Ser Ser Ile 
                85                  90                  95      


Thr Leu Asn Pro Asp Lys Pro Val Val Gly Gly Thr Val Thr Ala Ile 
            100                 105                 110         


Trp Thr Ala Lys Asp Ala Asn Asp Asn Pro Val Thr Gly Leu Asn Pro 
        115                 120                 125             


Asp Ala Pro Ser Leu Ser Gly Ala Ala Ala Ala Gly Ser Thr Ala Ser 
    130                 135                 140                 


Gly Trp Thr Asp Asn Gly Asp Gly Thr Trp Thr Ala Gln Ile Ser Leu 
145                 150                 155                 160 


Gly Thr Thr Ala Gly Glu Leu Asp Val Met Pro Lys Leu Asn Gly Gln 
                165                 170                 175     


Asp Ala Ala Ala Asn Ala Ala Lys Val Thr Val Val Ala Asp Ala Leu 
            180                 185                 190         


Ser Ser Asn Gln Ser Lys Val Ser Val Ala Glu Asp His Val Lys Ala 
        195                 200                 205             


Gly Glu Ser Thr Thr Val Thr Leu Val Ala Lys Asp Ala His Gly Asn 
    210                 215                 220                 


Ala Ile Ser Gly Leu Ser Leu Ser Ala Ser Leu Thr Gly Thr Ala Ser 
225                 230                 235                 240 


Glu Gly Ala Thr Val Ser Ser Trp Thr Glu Lys Gly Asp Gly Ser Tyr 
                245                 250                 255     


Val Ala Thr Leu Thr Thr Gly Gly Lys Thr Gly Glu Leu Arg Val Met 
            260                 265                 270         


Pro Leu Phe Asn Gly Gln Pro Ala Ala Thr Glu Ala Ala Gln Leu Thr 
        275                 280                 285             


Val Ile Ala Gly Glu Met Ser Ser Ala Asn Ser Thr Leu Val Ala Asp 
    290                 295                 300                 


Asn Lys Thr Pro Thr Val Lys Thr Thr Thr Glu Leu Thr Phe Thr Met 
305                 310                 315                 320 


Lys Asp Ala Tyr Gly Asn Pro Val Thr Gly Leu Lys Pro Asp Ala Pro 
                325                 330                 335     


Val Phe Ser Gly Ala Ala Ser Thr Gly Ser Glu Arg Pro Ser Ala Gly 
            340                 345                 350         


Asn Trp Thr Glu Lys Gly Asn Gly Val Tyr Val Ser Thr Leu Thr Leu 
        355                 360                 365             


Gly Ser Ala Ala Gly Gln Leu Ser Val Met Pro Arg Val Asn Gly Gln 
    370                 375                 380                 


Asn Ala Val Ala Gln Pro Leu Val Leu Asn Val Ala Gly Asp Ala Ser 
385                 390                 395                 400 


Lys Ala Glu Ile Arg Asp Met Thr Val Lys Val Asn Asn Gln 
                405                 410                 


