                         SEQUENCE LISTING

<110>  Ares Trading S.A.
 
<120>  Monoclonal antibody directed to FGFR1

<130>  P 16/240

<150>  US 62/425,325
<151>  2016-11-22

<150>  EP 16200304.0
<151>  2016-11-23

<150>  EP 17166540.9
<151>  2017-04-13

<160>  113    

<170>  PatentIn version 3.5

<210>  1
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variable heavy chain of antibody #A08 hit

<400>  1

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      

Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          

Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              

Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  

Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  

Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Gly Thr Asp Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         

Thr Val Ser Ser 
        115     


<210>  2
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variable light chain of antibody #A08 hit 

<400>  2

Gln Ala Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      

Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Glu Ser Val 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              

Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  

Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  

Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Thr Ser Asp His 
                85                  90                  95      

Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             

<210>  3
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-1 of the heavy chain of antibody #A08 hit and lead 

<400>  3

Gly Gly Ser Ile Ser Ser Asn Asn Trp 
1               5                   

<210>  4
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-2 of the heavy chain of antibody #A08 hit and lead 

<400>  4

Ile Tyr His Ser Gly Ser Thr 
1               5           


<210>  5
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-3 of the heavy chain of antibody #A08 hit and lead 

<400>  5

Ala Arg Gly Thr Asp Trp Phe Asp Pro 
1               5                   


<210>  6
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alternative CDR-1 of the heavy chain of antibody #A08 hit 

<400>  6

Gly Gly Ser Ile Ser Gly Asn Asn Trp 
1               5                   


<210>  7
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alternative CDR-1 of the heavy chain of antibody #A08 hit 

<400>  7

Gly Gly Ser Ile Asn Ser Asn His Trp 
1               5                   


<210>  8
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alternative CDR-2 of the heavy chain of antibody #A08 hit 

<400>  8

Ile Tyr His Ser Gly Ser Val 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alternative CDR-3 of the heavy chain of antibody #A08 hit 

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X being any residues selected from the group consisting of 
       proline (P), glutamine (Q), alanine (A), leucine (L), histidine 
       (H), serine (S) or threonine (T)

<400>  9

Ala Arg Ala Thr Asp Trp Phe Asp Xaa 
1               5                   

<210>  10
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alternative CDR-3 of the heavy chain of antibody #A08 hit 

<400>  10

Ala Arg Gly Thr Asp Trp Tyr Asp Pro 
1               5                   

<210>  11
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alternative CDR-3 of the heavy chain of antibody #A08 hit 

<400>  11

Ala Arg Gly Thr Asp Trp Ile Asp Thr 
1               5                   

<210>  12
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alternative CDR-3 of the heavy chain of antibody #A08 hit 

<400>  12

Ala Arg Ser Thr Asp Trp Phe Asp Pro 
1               5                   

<210>  13
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alternative CDR-3 of the heavy chain of antibody #A08 hit 

<400>  13

Ala Arg Gly Thr Asp Trp Tyr Asp Ala 
1               5                   

<210>  14
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alternative CDR-3 of the heavy chain of antibody #A08 hit 

<400>  14

Ala Arg Gly Thr Asp Trp Tyr Asp Leu 
1               5                   

<210>  15
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alternative CDR-3 of the heavy chain of antibody #A08 hit 

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X being any residues selected from the group consisting of S 
       serine (S) or valine (V)

<400>  15

Ala Arg Xaa Thr Asp Trp Phe Asp Pro 
1               5                   

<210>  16
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alternative CDR-3 of the heavy chain of antibody #A08 hit 

<400>  16

Ala Arg Ala Lys Asp Trp Phe Asp Ala 
1               5                   

<210>  17
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alternative CDR-3 of the heavy chain of antibody #A08 hit 

<400>  17

Ala Arg Ala Thr Asp Trp Tyr Asp Pro 
1               5                   

<210>  18
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-1 of the light chain of antibody #A08 hit and lead 

<400>  18

Asn Ile Gly Ser Glu Ser 
1               5       

<210>  19
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-2 of the light chain of antibody #A08 hit and lead 

<400>  19

Asp Asp Ser 
1               

<210>  20
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-3 of the light chain of antibody #A08 hit and lead 

<400>  20

Gln Val Trp Asp Ser Thr Ser Asp His Arg Val 
1               5                   10      

<210>  21
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alternative CDR-1 of the light chain of antibody #A08 hit 

<400>  21

Asn Ile Gly Asp Glu Thr 
1               5       

<210>  22
<211>  11
<212>  PRT
<213>  Alternative

<220>
<223>  alternative CDR-3 of the light chain of antibody #A08 hit 

<400>  22

Gln Val Trp Asp Ser Ser Val Asp Gln Ala Val 
1               5                   10      

<210>  23
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alternative CDR-3 of the light chain of antibody #A08 hit 

<400>  23

Gln Val Trp Asp Ser Ser Ser Asp His Arg Val 
1               5                   10      

<210>  24
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variable heavy chain of antibody #A08 lead 

<400>  24

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      

Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          

Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              

Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  

Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  

Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Gly Thr Asp Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         

Thr Val Ser Ser 
        115     

<210>  25
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variable light chain of antibody #A08 lead 

<400>  25

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      

Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Glu Ser Val 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              

Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  

Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  

Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Thr Ser Asp His 
                85                  90                  95      

Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             

<210>  26
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variable heavy chain of antibody #A05 hit 

<400>  26

Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Val Ser Cys Lys Ala Ser Gly His Thr Phe Thr Gly Tyr 
            20                  25                  30          

Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              

Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  

Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  

Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Asp Leu Phe Trp Ser Leu Ser Ser Gly Trp Ser Ile His Pro 
            100                 105                 110         

Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             

<210>  27
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variable heavy chain of antibody #A05 lead 

<400>  27

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Val Ser Cys Lys Ala Ser Gly His Thr Phe Thr Gly Tyr 
            20                  25                  30          

Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              

Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  

Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  

Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Asp Leu Phe Trp Ser Leu Ser Ser Gly Trp Ser Ile His Pro 
            100                 105                 110         

Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             

<210>  28
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variable light chain of antibody #A05 hit 

<400>  28

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          

Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              

Met Ile Tyr Gly Gly Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Asp Thr Ser Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Thr Tyr Asn 
                85                  90                  95      

Gly Asp Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu  
            100                 105                  

<210>  29
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Variable light chain of antibody #A05 lead 

<400>  29

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          

Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              

Met Ile Tyr Gly Gly Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Tyr Ser 
                85                  90                  95      

Gly Asp Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 

<210>  30
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR-1 of the heavy chain of antibody #A08 family

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X being any residues selected from the group consisting of 
       Glutamine (Q) and Gluamic acid (E)

<400>  30

Xaa Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      

Thr Leu Ser Leu Thr Cys Ala Val Ser 
            20                  25  

<210>  31
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR-2 of the heavy chain of antibody #A08 family 

<400>  31

Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      

Glu 
    

<210>  32
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR-3 of the heavy chain of antibody #A08 family 

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  X being any residues selected from the group consisting of Serine (S)
       or Asparagine (N)

<400>  32

Ser Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
1               5                   10                  15      

Ser Lys Asn Gln Phe Ser Leu Lys Leu Xaa Ser Val Thr Ala Ala Asp 
            20                  25                  30          

Thr Ala Val Tyr Tyr Cys 
        35              

<210>  33
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR-4 of the heavy chain of antibody #A08 family 

<400>  33

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

<210>  34
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR-1 of the light chain of antibody #A08 family 

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X in position 1 being any residues selected from the group 
       consisting of Glutamine (Q) and Serine (S)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X in position 2 being any residues selected from the group 
       consisting of Alanine (A), Serine (S) and Tyrosine (Y)

<400>  34

Xaa Xaa Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      

Thr Ala Arg Ile Thr Cys Gly Gly Asn 
            20                  25  

<210>  35
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR-2 of the light chain of antibody #A08 family 

<400>  35

Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val 
1               5                   10                  15      

Tyr 
    

<210>  36
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR-3 of the light chain of antibody #A08 family 

<400>  36

Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly 
1               5                   10                  15      

Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala 
            20                  25                  30          

Asp Tyr Tyr Cys 
        35      

<210>  37
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR-4 of the light chain of antibody #A08 family 

<400>  37

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
1               5                   10  

<210>  38
<211>  329
<212>  PRT
<213>  Artificial sequence

<220>
<223>  heavy chain constant region  human IgG1 allotype G1m3 

<400>  38

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      

Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  

Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      

Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         

Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             

Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 

Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 

Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     

Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         

His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             

Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 

Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 

Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     

Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         

Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             

Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 

Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 

Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 

<210>  39
<211>  328
<212>  PRT
<213>  Artificial sequence

<220>
<223>  heavy chain constant region  human IgG2 allotype G2h 

<400>  39

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      

Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  

Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  

Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      

Thr Val Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         

Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        115                 120                 125             

Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    130                 135                 140                 

Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
145                 150                 155                 160 

Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                165                 170                 175     

Gln Ala Gln Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
            180                 185                 190         

Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys 
        195                 200                 205             

Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
    210                 215                 220                 

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
225                 230                 235                 240 

Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                245                 250                 255     

Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            260                 265                 270         

Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        275                 280                 285             

Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    290                 295                 300                 

Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
305                 310                 315                 320 

Lys Ser Leu Ser Leu Ser Pro Gly 
                325             

<210>  40
<211>  332
<212>  PRT
<213>  Artificial sequence

<220>
<223>  heavy chain constant region CH1-hinge-CH2-CH3  SEED(AG) 

<400>  40

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      

Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  

Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      

Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         

Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             

Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 

Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 

Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     

Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         

His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             

Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 

Gln Pro Phe Arg Pro Glu Val His Leu Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 

Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Ala Arg Gly Phe Tyr 
                245                 250                 255     

Pro Lys Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         

Asn Tyr Lys Thr Thr Pro Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr 
        275                 280                 285             

Thr Phe Ala Val Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    290                 295                 300                 

Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
305                 310                 315                 320 

His Tyr Thr Gln Lys Thr Ile Ser Leu Ser Pro Gly 
                325                 330         

<210>  41
<211>  234
<212>  PRT
<213>  Artificial sequence

<220>
<223>  heavy chain constant region hinge-CH2-CH3  SEED(GA) 

<400>  41

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      

Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          

Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              

Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  

Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  

Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      

Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         

Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             

Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Pro Ser Glu Glu Leu Ala 
    130                 135                 140                 

Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 

Ser Asp Ile Ala Val Glu Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg 
                165                 170                 175     

Glu Lys Tyr Leu Thr Trp Ala Pro Val Leu Asp Ser Asp Gly Ser Phe 
            180                 185                 190         

Phe Leu Tyr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys Lys Gly 
        195                 200                 205             

Asp Thr Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 

Thr Gln Lys Ser Leu Asp Arg Ser Pro Gly 
225                 230                 

<210>  42
<211>  332
<212>  PRT
<213>  Artificial sequence

<220>
<223>  heavy chain constant region CH1-hinge-CH2-CH3  SEED(GA) 

<400>  42

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      

Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  

Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      

Arg Val Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         

Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             

Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 

Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 

Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     

Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         

His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             

Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 

Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Pro Ser Glu Glu 
225                 230                 235                 240 

Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Val Lys Gly Phe 
                245                 250                 255     

Tyr Pro Ser Asp Ile Ala Val Glu Trp Leu Gln Gly Ser Gln Glu Leu 
            260                 265                 270         

Pro Arg Glu Lys Tyr Leu Thr Trp Ala Pro Val Leu Asp Ser Asp Gly 
        275                 280                 285             

Ser Phe Phe Leu Tyr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys 
    290                 295                 300                 

Lys Gly Asp Thr Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
305                 310                 315                 320 

His Tyr Thr Gln Lys Ser Leu Asp Arg Ser Pro Gly 
                325                 330         

<210>  43
<211>  234
<212>  PRT
<213>  Artificial sequence

<220>
<223>  heavy chain constant region hinge-CH2-CH3  SEED(AG) 

<400>  43

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      

Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          

Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              

Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  

Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  

Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      

Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         

Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             

Phe Arg Pro Glu Val His Leu Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 

Lys Asn Gln Val Ser Leu Thr Cys Leu Ala Arg Gly Phe Tyr Pro Lys 
145                 150                 155                 160 

Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     

Lys Thr Thr Pro Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr Phe 
            180                 185                 190         

Ala Val Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        195                 200                 205             

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 

Thr Gln Lys Thr Ile Ser Leu Ser Pro Gly 
225                 230                 

<210>  44
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  light chain constant region (lambda)
<400>  44

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      

Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          

Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              

Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  

Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  

Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      

Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     

<210>  45
<211>  445
<212>  PRT
<213>  Artificial sequence

<220>
<223>  heavy chain for #A08 lead-IgG1m3 antibody 

<400>  45

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      

Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          

Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              

Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  

Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  

Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Gly Thr Asp Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         

Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             

Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 

Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 

Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     

Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         

Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             

Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 

Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     

Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         

Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             

Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 

Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 

Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     

Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         

Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             

Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 

Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 

Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     

Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         

Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 

<210>  46
<211>  448
<212>  PRT
<213>  Artificial sequence

<220>
<223>  heavy chain for #A08 lead-SEED(AG) antibody

<400>  46

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      

Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          

Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              

Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  

Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  

Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Gly Thr Asp Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         

Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             

Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 

Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 

Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     

Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         

Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             

Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 

Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     

Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         

Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             

Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 

Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 

Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     

Lys Ala Lys Gly Gln Pro Phe Arg Pro Glu Val His Leu Leu Pro Pro 
            340                 345                 350         

Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Ala 
        355                 360                 365             

Arg Gly Phe Tyr Pro Lys Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 

Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Ser Arg Gln Glu Pro Ser 
385                 390                 395                 400 

Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     

Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         

Ala Leu His Asn His Tyr Thr Gln Lys Thr Ile Ser Leu Ser Pro Gly 
        435                 440                 445             

<210>  47
<211>  448
<212>  PRT
<213>  Artificial sequence

<220>
<223>  heavy chain for #A08 lead-SEED(GA) antibody 

<400>  47

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      

Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          

Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              

Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  

Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  

Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Gly Thr Asp Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         

Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             

Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 

Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 

Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     

Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         

Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             

Lys Val Asp Lys Arg Val Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
    210                 215                 220                 

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 

Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     

Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         

Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             

Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 

Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 

Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     

Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         

Pro Ser Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu 
        355                 360                 365             

Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Leu Gln Gly 
    370                 375                 380                 

Ser Gln Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Pro Val Leu 
385                 390                 395                 400 

Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Ile Leu Arg Val Ala Ala 
                405                 410                 415     

Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         

Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Asp Arg Ser Pro Gly 
        435                 440                 445             

<210>  48
<211>  460
<212>  PRT
<213>  Artificial sequence

<220>
<223>  heavy chain for #A05 lead-SEED(AG) antibody 

<400>  48

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Val Ser Cys Lys Ala Ser Gly His Thr Phe Thr Gly Tyr 
            20                  25                  30          

Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              

Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  

Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  

Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Asp Leu Phe Trp Ser Leu Ser Ser Gly Trp Ser Ile His Pro 
            100                 105                 110         

Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 

Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             

Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 

Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 

Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     

Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         

Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        275                 280                 285             

Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 

Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
305                 310                 315                 320 

His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     

Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            340                 345                 350         

Gln Pro Phe Arg Pro Glu Val His Leu Leu Pro Pro Ser Arg Glu Glu 
        355                 360                 365             

Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Ala Arg Gly Phe Tyr 
    370                 375                 380                 

Pro Lys Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 

Asn Tyr Lys Thr Thr Pro Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr 
                405                 410                 415     

Thr Phe Ala Val Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         

Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             

His Tyr Thr Gln Lys Thr Ile Ser Leu Ser Pro Gly 
    450                 455                 460 

<210>  49
<211>  460
<212>  PRT
<213>  Artificial sequence

<220>
<223>  heavy chain for #A05 lead-SEED(GA) antibody

<400>  49

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Val Ser Cys Lys Ala Ser Gly His Thr Phe Thr Gly Tyr 
            20                  25                  30          

Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              

Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  

Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  

Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Asp Leu Phe Trp Ser Leu Ser Ser Gly Trp Ser Ile His Pro 
            100                 105                 110         

Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 

Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             

Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 

Arg Val Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 

Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     

Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         

Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        275                 280                 285             

Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 

Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
305                 310                 315                 320 

His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     

Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            340                 345                 350         

Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Pro Ser Glu Glu 
        355                 360                 365             

Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 

Tyr Pro Ser Asp Ile Ala Val Glu Trp Leu Gln Gly Ser Gln Glu Leu 
385                 390                 395                 400 

Pro Arg Glu Lys Tyr Leu Thr Trp Ala Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     

Ser Phe Phe Leu Tyr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys 
            420                 425                 430         

Lys Gly Asp Thr Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             

His Tyr Thr Gln Lys Ser Leu Asp Arg Ser Pro Gly 
    450                 455                 460 

<210>  50
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Light chain for #A08 lead 

<400>  50

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      

Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Glu Ser Val 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              

Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  

Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  

Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Thr Ser Asp His 
                85                  90                  95      

Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         

Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             

Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 

Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 

Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     

Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser 
            180                 185                 190         

Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             

Ala Pro Thr Glu Cys Ser 
    210                 

<210>  51
<211>  215
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Light chain for #A05 lead 

<400>  51

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          

Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              

Met Ile Tyr Gly Gly Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Tyr Ser 
                85                  90                  95      

Gly Asp Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln Pro 
            100                 105                 110         

Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             

Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 

Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 

Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     

Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys 
            180                 185                 190         

Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             

Val Ala Pro Thr Glu Cys Ser 
    210                 215 

<210>  52
<211>  348
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variable heavy chain of antibody #A08 hit 

<400>  52
gaggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggggac cctgtccctc       60

acctgcgctg tctctggtgg ctccatcagc agtaataact ggtggagttg ggtccgccag      120

cccccaggga aggggctgga gtggattggg gaaatctatc atagtgggag caccagctac      180

aacccgtccc tcaagagtcg agtcaccata tcagtagaca agtccaagaa ccagttctcc      240

ctgaagctga actctgtgac cgccgcggac acggccgtgt attactgtgc gagaggcacc      300

gactggttcg acccctgggg ccagggaacc ctggtcaccg tctcctca                   348


<210>  53
<211>  324
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variable light chain of antibody #A08 hit 

<400>  53
caggctgtgc tgactcagcc accctcggtg tcagtggccc caggacagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtgaa agtgtgcact ggtaccaaca gaagccaggc      120

caggcccctg tgctggtcgt ctatgatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatagtacta gtgatcatcg ggtattcggc      300

ggagggacca agctcaccgt ccta                                             324


<210>  54
<211>  348
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variable heavy chain of antibody #A08 lead

<400>  54
gaggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggggac cctgtccctc       60

acctgcgctg tctctggtgg ctccatcagc agtaataact ggtggagttg ggtccgccag      120

cccccaggga aggggctgga gtggattggg gaaatctatc atagtgggag caccagctac      180

aacccgtccc tcaagagtcg agtcaccata tcagtagaca agtccaagaa ccagttctcc      240

ctgaagctgt cctctgtgac cgccgcggac acggccgtgt attactgtgc gagaggcacc      300

gactggttcg acccctgggg ccagggaacc ctggtcaccg tctcctca                   348


<210>  55
<211>  324
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variable light chain of antibody #A08 lead

<400>  55
tcctacgtgc tgactcagcc accctcggtg tcagtggccc caggacagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtgaa agtgtgcact ggtaccaaca gaagccaggc      120

caggcccctg tgctggtcgt ctatgatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatagtacta gtgatcatcg ggtattcggc      300

ggagggacca agctcaccgt ccta                                             324


<210>  56
<211>  384
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variable heavy chain of antibody #A05 hit 

<400>  56
caaatgcagc tggtacaatc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggaca caccttcacc ggctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacccta acagtggtgg cacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gagagatctt      300

ttctggtcct tgagcagtgg ctggtctatc catccgtact actttgacta ctggggccag      360

ggaaccctgg tcaccgtctc ctca                                             384


<210>  57
<211>  384
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variable heavy chain of antibody #A05 lead 

<400>  57
gaggtgcagc tggtacaatc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggaca caccttcacc ggctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacccta acagtggtgg cacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gagagatctt      300

ttctggtcct tgagcagtgg ctggtctatc catccgtact actttgacta ctggggccag      360

ggaaccctgg tcaccgtctc ctca                                             384


<210>  58
<211>  327
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variable light chain of antibody #A05 hit 

<400>  58
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgatgttggg agttataacc ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgggggca gtaagcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctgac acctcagcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc tgctcatata catacaatgg ggatgtcttc      300

ggaactggga ccaaggtcac cgtccta                                          327


<210>  59
<211>  327
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Variable light chain of antibody #A05 lead 

<400>  59
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgatgttggg agttataacc ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgggggca gtaagcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc aacaccgcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata catacagcgg ggatgtcttc      300

ggaactggga ccaaggtcac cgtccta                                          327


<210>  60
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-1 of the heavy chain of antibodies #A05 hit and lead 

<400>  60

Gly His Thr Phe Thr Gly Tyr Tyr 
1               5               


<210>  61
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-2 of the heavy chain of antibodies #A05 hit and lead 

<400>  61

Ile Asn Pro Asn Ser Gly Gly Thr 
1               5               


<210>  62
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-3 of the heavy chain of antibodies #A05 hit and lead 

<400>  62

Ala Arg Asp Leu Phe Trp Ser Leu Ser Ser Gly Trp Ser Ile His Pro 
1               5                   10                  15      


Tyr Tyr Phe Asp Tyr 
            20      


<210>  63
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-1 of the light chain of antibodies #A05 hit and lead 

<400>  63

Ser Ser Asp Val Gly Ser Tyr Asn Leu 
1               5                   


<210>  64
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-2 of the light chain of antibodies #A05 hit and lead 

<400>  64

Gly Gly Ser 
1               


<210>  65
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-3 of the light chain of antibody #A05 hit 

<400>  65

Cys Ser Tyr Thr Tyr Asn Gly Asp Val 
1               5                   


<210>  66
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR-3 of the light chain of antibody #A05 lead

<400>  66

Ser Ser Tyr Thr Tyr Ser Gly Asp Val 
1               5                   


<210>  67
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR-1 of the heavy chain of antibody #A05 family 


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X in position 1 being any residues selected from the group 
       consisting of Q and E

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X in position 2 being any residues selected from the group 
       consisting of Methionine (M) and V

<400>  67

Xaa Xaa Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  68
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR-2 of the heavy chain of antibody #A05 family 

<400>  68

Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Trp 
    


<210>  69
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR-3 of the heavy chain of antibody #A05 family 

<400>  69

Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
1               5                   10                  15      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  70
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR-4 of the heavy chain of antibody #A05 family 

<400>  70

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  71
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR-1 of the light chain of antibody #A05 family 

<400>  71

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr 
            20                  25  


<210>  72
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR-2 of the light chain of antibody #A05 family 

<400>  72

Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile 
1               5                   10                  15      


Tyr 
    


<210>  73
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR-3 of the light chain of antibody #A05 family 

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X in position 16 being any residues selected from the group 
       consisting of Aspartic acid (D) and Glycine (G)

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X in position 17 being any residues selected from the group 
       consisting of T and N

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X in position 18 being any residues selected from the group 
       consisting of S and T

<400>  73

Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Xaa 
1               5                   10                  15      


Xaa Xaa Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala 
            20                  25                  30          


Asp Tyr Tyr Cys 
        35      


<210>  74
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR-4 of the light chain of antibody #A05 family 

<400>  74

Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
1               5                   10  


<210>  75
<211>  318
<212>  DNA
<213>  Artificial sequence

<220>
<223>  light chain constant region (lambda) 

<400>  75
ggacagccca aggctgcccc ctcggtcact ctgttcccgc cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tacctgagcc tgacgcctga gcagtggaag      240

tcccacaaaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttca                                                    318


<210>  76
<211>  987
<212>  DNA
<213>  Artificial sequence

<220>
<223>  heavy chain constant region  human IgG1 allotype G1m3
<400>  76
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc acgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc cccgggt                                          987


<210>  77
<211>  984
<212>  DNA
<213>  Artificial sequence

<220>
<223>  heavy chain constant region  human IgG2 allotype G2h 

<400>  77
gctagcacca agggcccatc ggtcttcccc ctggcgccct gctccaggag cacctccgag       60

agcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cagctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcaacttcgg cacccagacc      240

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagac agttgagccc      300

aaatcttctg acaaaactca cacatgccca ccgtgcccag caccacctgt ggcaggaccg      360

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      420

gtcacgtgcg tggtggtgga cgtgagccac gaagaccccg aggtccagtt caactggtac      480

gtggacggcg tggaggtgca taatgccaag acaaagccac gggaggagca ggcccagagc      540

acgttccgtg tggtcagcgt cctcaccgtt gtgcaccagg actggctgaa cggcaaggag      600

tacaagtgcg ctgtctccaa caaaggcctc ccagccccca tcgagaaaac catctccaaa      660

accaaagggc agccccgaga accacaggtg tacaccctgc ccccatcacg ggaggagatg      720

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctaccccag cgacatcgcc      780

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacacc tcccatgctg      840

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag      900

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacacag      960

aagagcctct ccctgtcccc gggt                                             984


<210>  78
<211>  996
<212>  DNA
<213>  Artificial sequence

<220>
<223>  heavy chain constant region  SEED(AG) 

<400>  78
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctggggggg      360

ccctcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc tagaacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aacgatatcc      660

aaagccaaag ggcagccctt ccggccagag gtccacctgc tgcccccatc acgggaggag      720

atgaccaaga accaggtcag cctgacctgc ctggcacgcg gcttctatcc caaggacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gccttcccgg      840

caggagccca gccagggcac caccaccttc gctgtgacct cgaagctcac cgtggacaag      900

agcagatggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac      960

cactacacgc agaagaccat ctccctgtcc ccgggt                                996


<210>  79
<211>  702
<212>  DNA
<213>  Artificial sequence

<220>
<223>  heavy chain constant region  SEED(GA) 

<400>  79
gagcccaaat cttctgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg       60

ggggggccct cagtcttcct cttcccccca aaacccaagg acaccctcat gatctctaga      120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacg      360

atatccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccaccgtcg      420

gaggagctgg ccctgaacga gctggtgacg ctgacctgcc tggtcaaagg cttctatccc      480

agcgacatcg ccgtggagtg gctgcagggg tcccaggagc tgccccgcga gaagtacctg      540

acttgggcac ccgtgctgga ctccgacggc tccttcttcc tctatagtat actgcgcgtg      600

gcagccgagg actggaagaa gggggacacc ttctcatgct ccgtgatgca tgaggctctg      660

cacaaccact acacgcagaa gagcctcgac cgctccccgg gt                         702


<210>  80
<211>  263
<212>  PRT
<213>  Homo sapiens

<220>
<223>  human FGFR1b-IIIb extracellular domain 

<400>  80

Arg Pro Ser Pro Thr Leu Pro Glu Gln Asp Ala Leu Pro Ser Ser Glu 
1               5                   10                  15      


Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp 
            20                  25                  30          


Asn Thr Lys Pro Asn Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
        35                  40                  45              


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
    50                  55                  60                  


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
65                  70                  75                  80  


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
                85                  90                  95      


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
            100                 105                 110         


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
        115                 120                 125             


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
    130                 135                 140                 


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
145                 150                 155                 160 


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
                165                 170                 175     


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
            180                 185                 190         


Leu Pro Tyr Val Gln Ile Leu Lys His Ser Gly Ile Asn Ser Ser Asp 
        195                 200                 205             


Ala Glu Val Leu Thr Leu Phe Asn Val Thr Glu Ala Gln Ser Gly Glu 
    210                 215                 220                 


Tyr Val Cys Lys Val Ser Asn Tyr Ile Gly Glu Ala Asn Gln Ser Ala 
225                 230                 235                 240 


Trp Leu Thr Val Thr Arg Pro Ala Leu Glu Glu Arg Pro Ala Val Met 
                245                 250                 255     


Thr Ser Pro Leu Tyr Leu Glu 
            260             


<210>  81
<211>  264
<212>  PRT
<213>  Homo sapiens

<220>
<223>  human FGFR1b-IIIc extracellular domain 

<400>  81

Arg Pro Ser Pro Thr Leu Pro Glu Gln Asp Ala Leu Pro Ser Ser Glu 
1               5                   10                  15      


Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp 
            20                  25                  30          


Asn Thr Lys Pro Asn Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
        35                  40                  45              


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
    50                  55                  60                  


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
65                  70                  75                  80  


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
                85                  90                  95      


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
            100                 105                 110         


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
        115                 120                 125             


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
    130                 135                 140                 


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
145                 150                 155                 160 


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
                165                 170                 175     


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
            180                 185                 190         


Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
        195                 200                 205             


Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
    210                 215                 220                 


Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
225                 230                 235                 240 


Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
                245                 250                 255     


Met Thr Ser Pro Leu Tyr Leu Glu 
            260                 


<210>  82
<211>  266
<212>  PRT
<213>  Mus musculus

<220>
<223>  mouse FGFR1b-IIIb extracellular domain 

<400>  82

Arg Pro Ala Pro Thr Leu Pro Glu Gln Asp Ala Leu Pro Ser Ser Glu 
1               5                   10                  15      


Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp 
            20                  25                  30          


Asn Thr Lys Pro Asn Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
        35                  40                  45              


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
    50                  55                  60                  


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
65                  70                  75                  80  


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
                85                  90                  95      


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
            100                 105                 110         


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
        115                 120                 125             


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
    130                 135                 140                 


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
145                 150                 155                 160 


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
                165                 170                 175     


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
            180                 185                 190         


Leu Pro Tyr Val Gln Ile Leu Lys His Ser Gly Ile Asn Ser Ser Asp 
        195                 200                 205             


Ala Glu Val Leu Thr Leu Phe Asn Val Thr Glu Ala Gln Ser Gly Glu 
    210                 215                 220                 


Tyr Val Cys Lys Val Ser Asn Tyr Ile Gly Glu Ala Asn Gln Ser Ala 
225                 230                 235                 240 


Trp Leu Thr Val Thr Arg Pro Val Ala Lys Ala Leu Glu Glu Arg Pro 
                245                 250                 255     


Ala Val Met Thr Ser Pro Leu Tyr Leu Glu 
            260                 265     


<210>  83
<211>  264
<212>  PRT
<213>  Mus musculus

<220>
<223>  mouse FGFR1b-IIIc extracellular domain 

<400>  83

Arg Pro Ala Pro Thr Leu Pro Glu Gln Asp Ala Leu Pro Ser Ser Glu 
1               5                   10                  15      


Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp 
            20                  25                  30          


Asn Thr Lys Pro Asn Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
        35                  40                  45              


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
    50                  55                  60                  


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
65                  70                  75                  80  


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
                85                  90                  95      


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
            100                 105                 110         


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
        115                 120                 125             


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
    130                 135                 140                 


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
145                 150                 155                 160 


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
                165                 170                 175     


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
            180                 185                 190         


Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
        195                 200                 205             


Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
    210                 215                 220                 


Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
225                 230                 235                 240 


Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
                245                 250                 255     


Met Thr Ser Pro Leu Tyr Leu Glu 
            260                 


<210>  84
<211>  148
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial sequence

<400>  84

Arg Pro Ser Pro Thr Leu Pro Glu Gln Asp Ala Leu Pro Ser Ser Glu 
1               5                   10                  15      

Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp 
            20                  25                  30          

Asn Thr Lys Pro Asn Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
        35                  40                  45              

Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
    50                  55                  60                  

Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
65                  70                  75                  80  

Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
                85                  90                  95      

Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
            100                 105                 110         

Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
        115                 120                 125             

His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg His His 
    130                 135                 140                 

His His His His 
145             


<210>  85
<211>  129
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human FGFR1-IIIc D3-His6 

<400>  85

Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu 
1               5                   10                  15      


Gly Ser Asn Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro 
            20                  25                  30          


His Ile Gln Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly 
        35                  40                  45              


Pro Asp Asn Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn 
    50                  55                  60                  


Thr Thr Asp Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe 
65                  70                  75                  80  


Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu 
                85                  90                  95      


Ser His His Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg 
            100                 105                 110         


Pro Ala Val Met Thr Ser Pro Leu Tyr Leu Glu His His His His His 
        115                 120                 125             

His 


<210>  86
<211>  269
<212>  PRT
<213>  Artificial sequence

<220>
<223>  human FGFR1b-IIIb extracellular domain with a HIS tag

<400>  86

Arg Pro Ser Pro Thr Leu Pro Glu Gln Asp Ala Leu Pro Ser Ser Glu 
1               5                   10                  15      


Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp 
            20                  25                  30          


Asn Thr Lys Pro Asn Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
        35                  40                  45              


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
    50                  55                  60                  


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
65                  70                  75                  80  


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
                85                  90                  95      


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
            100                 105                 110         


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
        115                 120                 125             


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
    130                 135                 140                 


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
145                 150                 155                 160 


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
                165                 170                 175     


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
            180                 185                 190         


Leu Pro Tyr Val Gln Ile Leu Lys His Ser Gly Ile Asn Ser Ser Asp 
        195                 200                 205             


Ala Glu Val Leu Thr Leu Phe Asn Val Thr Glu Ala Gln Ser Gly Glu 
    210                 215                 220                 


Tyr Val Cys Lys Val Ser Asn Tyr Ile Gly Glu Ala Asn Gln Ser Ala 
225                 230                 235                 240 


Trp Leu Thr Val Thr Arg Pro Ala Leu Glu Glu Arg Pro Ala Val Met 
                245                 250                 255     


Thr Ser Pro Leu Tyr Leu Glu His His His His His His 
            260                 265                 


<210>  87
<211>  270
<212>  PRT
<213>  Artificial sequence

<220>
<223>  human FGFR1b-IIIc extracellular domain with a HIS tag

<400>  87

Arg Pro Ser Pro Thr Leu Pro Glu Gln Asp Ala Leu Pro Ser Ser Glu 
1               5                   10                  15      


Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp 
            20                  25                  30          


Asn Thr Lys Pro Asn Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
        35                  40                  45              


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
    50                  55                  60                  


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
65                  70                  75                  80  


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
                85                  90                  95      


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
            100                 105                 110         


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
        115                 120                 125             


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
    130                 135                 140                 


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
145                 150                 155                 160 


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
                165                 170                 175     


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
            180                 185                 190         


Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
        195                 200                 205             


Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
    210                 215                 220                 


Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
225                 230                 235                 240 


Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
                245                 250                 255     


Met Thr Ser Pro Leu Tyr Leu Glu His His His His His His 
            260                 265                 270 


<210>  88
<211>  272
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mouse FGFR1b-IIIb extracellular domain with His tag

<400>  88

Arg Pro Ala Pro Thr Leu Pro Glu Gln Asp Ala Leu Pro Ser Ser Glu 
1               5                   10                  15      


Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp 
            20                  25                  30          


Asn Thr Lys Pro Asn Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
        35                  40                  45              


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
    50                  55                  60                  


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
65                  70                  75                  80  


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
                85                  90                  95      


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
            100                 105                 110         


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
        115                 120                 125             


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
    130                 135                 140                 


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
145                 150                 155                 160 


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
                165                 170                 175     


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
            180                 185                 190         


Leu Pro Tyr Val Gln Ile Leu Lys His Ser Gly Ile Asn Ser Ser Asp 
        195                 200                 205             


Ala Glu Val Leu Thr Leu Phe Asn Val Thr Glu Ala Gln Ser Gly Glu 
    210                 215                 220                 


Tyr Val Cys Lys Val Ser Asn Tyr Ile Gly Glu Ala Asn Gln Ser Ala 
225                 230                 235                 240 


Trp Leu Thr Val Thr Arg Pro Val Ala Lys Ala Leu Glu Glu Arg Pro 
                245                 250                 255     


Ala Val Met Thr Ser Pro Leu Tyr Leu Glu His His His His His His 
            260                 265                 270         


<210>  89
<211>  270
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mouse FGFR1b-IIIc extracellular domain with His tag

<400>  89
Arg Pro Ala Pro Thr Leu Pro Glu Gln Asp Ala Leu Pro Ser Ser Glu 
1               5                   10                  15      


Asp Asp Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp 
            20                  25                  30          


Asn Thr Lys Pro Asn Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
        35                  40                  45              


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
    50                  55                  60                  


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
65                  70                  75                  80  


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
                85                  90                  95      


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
            100                 105                 110         


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
        115                 120                 125             


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
    130                 135                 140                 


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
145                 150                 155                 160 


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
                165                 170                 175     


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
            180                 185                 190         


Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
        195                 200                 205             


Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
    210                 215                 220                 


Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
225                 230                 235                 240 


Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
                245                 250                 255     


Met Thr Ser Pro Leu Tyr Leu Glu His His His His His His 
            260                 265                 270


<210>  90
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  alternative CDR-3 of the heavy chain of antibody #A08 hit 

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any one of S, G, A or V
<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any one of T or K

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any one of F, Y or I

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any one of P, L, A, T or H

<400>  90

Ala Arg Xaa Xaa Asp Trp Xaa Asp Xaa 
1               5                   


<210>  91
<211>  116
<212>  PRT
<213>  artificial

<220>
<223>  Alternative variable heavy chain of antibody #A08 

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any one of E or Q

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  Xaa can be any one of S, G, A or V

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa can be any one of T or K

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  Xaa can be any one of F, Y or I

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  Xaa can be any one of P, L, A, T or H

<400>  91

Xaa Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Xaa Xaa Asp Trp Xaa Asp Xaa Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  92
<211>  116
<212>  PRT
<213>  artificial

<220>
<223>  variable heavy chain for #B10-SEED(AG) antibody 

<400>  92

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Thr Asp Trp Tyr Asp Pro Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  93
<211>  116
<212>  PRT
<213>  artificial

<220>
<223>  variable heavy chain for #A02-SEED(AG) antibody 

<400>  93

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Thr Asp Trp Phe Asp Leu Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  94
<211>  116
<212>  PRT
<213>  artificial

<220>
<223>  variable heavy chain for #G04-SEED(AG) antibody 

<400>  94

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Asp Trp Tyr Asp Leu Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  95
<211>  116
<212>  PRT
<213>  artificial

<220>
<223>  variable heavy chain for #D02-SEED(AG) antibody 

<400>  95

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Asp Trp Ile Asp Thr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  96
<211>  116
<212>  PRT
<213>  artificial

<220>
<223>  variable heavy chain for #D01-SEED(AG) antibody 

<400>  96

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Thr Asp Trp Phe Asp His Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  97
<211>  116
<212>  PRT
<213>  artificial

<220>
<223>  variable heavy chain for #C01-SEED(AG) antibody 

<400>  97

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Thr Asp Trp Phe Asp Ala Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  98
<211>  116
<212>  PRT
<213>  artificial

<220>
<223>  variable heavy chain for #A07-SEED(AG) antibody 

<400>  98

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Asp Trp Tyr Asp Pro Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  99
<211>  448
<212>  PRT
<213>  artificial

<220>
<223>  alternative heavy chain for #A08 lead-SEED(AG) antibody 

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any one of E or Q

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  Xaa can be any one of S, G, A or V

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa can be any one of T or K

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  Xaa can be any one of F, Y or I

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  Xaa can be any one of P, L, A, T or H

<400>  99

Xaa Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Xaa Xaa Asp Trp Xaa Asp Xaa Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Phe Arg Pro Glu Val His Leu Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Ala 
        355                 360                 365             


Arg Gly Phe Tyr Pro Lys Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Ser Arg Gln Glu Pro Ser 
385                 390                 395                 400 


Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Thr Ile Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  100
<211>  448
<212>  PRT
<213>  artificial

<220>
<223>  heavy chain for #B10-SEED(AG) antibody 

<400>  100

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Thr Asp Trp Tyr Asp Pro Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Phe Arg Pro Glu Val His Leu Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Ala 
        355                 360                 365             


Arg Gly Phe Tyr Pro Lys Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Ser Arg Gln Glu Pro Ser 
385                 390                 395                 400 


Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Thr Ile Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  101
<211>  448
<212>  PRT
<213>  artificial

<220>
<223>  heavy chain for #A02-SEED(AG) antibody 

<400>  101

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Thr Asp Trp Phe Asp Leu Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Phe Arg Pro Glu Val His Leu Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Ala 
        355                 360                 365             


Arg Gly Phe Tyr Pro Lys Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Ser Arg Gln Glu Pro Ser 
385                 390                 395                 400 


Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Thr Ile Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  102
<211>  448
<212>  PRT
<213>  artificial

<220>
<223>  heavy chain for #G04-SEED(AG) antibody 

<400>  102

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Asp Trp Tyr Asp Leu Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Phe Arg Pro Glu Val His Leu Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Ala 
        355                 360                 365             


Arg Gly Phe Tyr Pro Lys Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Ser Arg Gln Glu Pro Ser 
385                 390                 395                 400 


Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Thr Ile Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  103
<211>  448
<212>  PRT
<213>  artificial

<220>
<223>  heavy chain for #D02-SEED(AG) antibody 

<400>  103

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Asp Trp Ile Asp Thr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Phe Arg Pro Glu Val His Leu Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Ala 
        355                 360                 365             


Arg Gly Phe Tyr Pro Lys Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Ser Arg Gln Glu Pro Ser 
385                 390                 395                 400 


Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Thr Ile Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  104
<211>  448
<212>  PRT
<213>  artificial

<220>
<223>  heavy chain for #D01-SEED(AG) antibody 

<400>  104

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Thr Asp Trp Phe Asp His Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Phe Arg Pro Glu Val His Leu Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Ala 
        355                 360                 365             


Arg Gly Phe Tyr Pro Lys Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Ser Arg Gln Glu Pro Ser 
385                 390                 395                 400 


Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Thr Ile Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  105
<211>  448
<212>  PRT
<213>  artificial

<220>
<223>  heavy chain for #C01-SEED(AG) antibody 

<400>  105

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Thr Asp Trp Phe Asp Ala Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Phe Arg Pro Glu Val His Leu Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Ala 
        355                 360                 365             


Arg Gly Phe Tyr Pro Lys Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Ser Arg Gln Glu Pro Ser 
385                 390                 395                 400 


Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Thr Ile Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  106
<211>  448
<212>  PRT
<213>  artificial

<220>
<223>  heavy chain for #A07-SEED(AG) antibody

<400>  106

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Asp Trp Tyr Asp Pro Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Phe Arg Pro Glu Val His Leu Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Ala 
        355                 360                 365             


Arg Gly Phe Tyr Pro Lys Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Ser Arg Gln Glu Pro Ser 
385                 390                 395                 400 


Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Thr Ile Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  107
<211>  1344
<212>  DNA
<213>  artificial

<220>
<223>  heavy chain for #B10-SEED(AG) antibody 

<400>  107
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggggac cctgtccctc       60

acctgcgctg tctctggtgg ctccatcagc agtaataact ggtggagttg ggtccgccag      120

cccccaggga aggggctgga gtggattggg gaaatctatc atagtgggag caccagctac      180

aacccgtccc tcaagagtcg agtcaccata tcagtagaca agtccaagaa ccagttctcc      240

ctgaagctgt cctctgtgac cgccgcggac acggccgtgt attactgtgc gagagccacc      300

gattggtacg acccgtgggg ccagggaacc ctggtcactg tctcttcagc tagcaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac      660

aaaactcaca catgcccacc gtgcccagca cctgaactcc tgggggggcc ctcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctcta gaacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagccccc atcgagaaaa cgatatccaa agccaaaggg     1020

cagcccttcc ggccagaggt ccacctgctg cccccatcac gggaggagat gaccaagaac     1080

caggtcagcc tgacctgcct ggcacgcggc ttctatccca aggacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc cttcccggca ggagcccagc     1200

cagggcacca ccaccttcgc tgtgacctcg aagctcaccg tggacaagag cagatggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagaccatct ccctgtcccc gggt                                            1344


<210>  108
<211>  1344
<212>  DNA
<213>  artificial

<220>
<223>  heavy chain for #A02-SEED(AG) antibody 

<400>  108
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggggac cctgtccctc       60

acctgcgctg tctctggtgg ctccatcagc agtaataact ggtggagttg ggtccgccag      120

cccccaggga aggggctgga gtggattggg gaaatctatc atagtgggag caccagctac      180

aacccgtccc tcaagagtcg agtcaccata tcagtagaca agtccaagaa ccagttctcc      240

ctgaagctgt cctctgtgac cgccgcggac acggccgtgt attactgtgc gagagcgacc      300

gactggtttg acctctgggg ccagggaacc ctggtcaccg tctcttcagc tagcaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac      660

aaaactcaca catgcccacc gtgcccagca cctgaactcc tgggggggcc ctcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctcta gaacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagccccc atcgagaaaa cgatatccaa agccaaaggg     1020

cagcccttcc ggccagaggt ccacctgctg cccccatcac gggaggagat gaccaagaac     1080

caggtcagcc tgacctgcct ggcacgcggc ttctatccca aggacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc cttcccggca ggagcccagc     1200

cagggcacca ccaccttcgc tgtgacctcg aagctcaccg tggacaagag cagatggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagaccatct ccctgtcccc gggt                                            1344


<210>  109
<211>  1344
<212>  DNA
<213>  artificial

<220>
<223>  heavy chain for #G04-SEED(AG) antibody 

<400>  109
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggggac cctgtccctc       60

acctgcgctg tctctggtgg ctccatcagc agtaataact ggtggagttg ggtccgccag      120

cccccaggga aggggctgga gtggattggg gaaatctatc atagtgggag caccagctac      180

aacccgtccc tcaagagtcg agtcaccata tcagtagaca agtccaagaa ccagttctcc      240

ctgaagctgt cctctgtgac cgccgcggac acggccgtgt attactgtgc gagagggacg      300

gactggtatg acctctgggg ccagggaacc ctggtcaccg tctcttcggc tagcaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac      660

aaaactcaca catgcccacc gtgcccagca cctgaactcc tgggggggcc ctcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctcta gaacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagccccc atcgagaaaa cgatatccaa agccaaaggg     1020

cagcccttcc ggccagaggt ccacctgctg cccccatcac gggaggagat gaccaagaac     1080

caggtcagcc tgacctgcct ggcacgcggc ttctatccca aggacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc cttcccggca ggagcccagc     1200

cagggcacca ccaccttcgc tgtgacctcg aagctcaccg tggacaagag cagatggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagaccatct ccctgtcccc gggt                                            1344


<210>  110
<211>  1344
<212>  DNA
<213>  artificial

<220>
<223>  heavy chain for #D02-SEED(AG) antibody 

<400>  110
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggggac cctgtccctc       60

acctgcgctg tctctggtgg ctccatcagc agtaataact ggtggagttg ggtccgccag      120

cccccaggga aggggctgga gtggattggg gaaatctatc atagtgggag caccagctac      180

aacccgtccc tcaagagtcg agtcaccata tcagtagaca agtccaagaa ccagttctcc      240

ctgaagctgt cctctgtgac cgccgcggac acggccgtgt attactgtgc gagagggact      300

gattggatcg acacctgggg ccagggaacc ctggtcactg tctcctcagc tagcaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac      660

aaaactcaca catgcccacc gtgcccagca cctgaactcc tgggggggcc ctcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctcta gaacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagccccc atcgagaaaa cgatatccaa agccaaaggg     1020

cagcccttcc ggccagaggt ccacctgctg cccccatcac gggaggagat gaccaagaac     1080

caggtcagcc tgacctgcct ggcacgcggc ttctatccca aggacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc cttcccggca ggagcccagc     1200

cagggcacca ccaccttcgc tgtgacctcg aagctcaccg tggacaagag cagatggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagaccatct ccctgtcccc gggt                                            1344


<210>  111
<211>  1344
<212>  DNA
<213>  artificial

<220>
<223>  heavy chain for #D01-SEED(AG) antibody 

<400>  111
caggtgcaac tgcaggagtc gggcccagga ctggtgaagc cttcggggac cctgtccctc       60

acctgcgctg tctctggtgg ctccatcagc agtaataact ggtggagttg ggtccgccag      120

cccccaggga aggggctgga gtggattggg gaaatctatc atagtgggag caccagctac      180

aacccgtccc tcaagagtcg agtcaccata tcagtagaca agtccaagaa ccagttctcc      240

ctgaagctgt cctctgtgac cgccgcggac acggccgtgt attactgtgc gagagccacg      300

gattggtttg accactgggg ccagggaacc ctggtcaccg tctcctcagc tagcaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac      660

aaaactcaca catgcccacc gtgcccagca cctgaactcc tgggggggcc ctcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctcta gaacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagccccc atcgagaaaa cgatatccaa agccaaaggg     1020

cagcccttcc ggccagaggt ccacctgctg cccccatcac gggaggagat gaccaagaac     1080

caggtcagcc tgacctgcct ggcacgcggc ttctatccca aggacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc cttcccggca ggagcccagc     1200

cagggcacca ccaccttcgc tgtgacctcg aagctcaccg tggacaagag cagatggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagaccatct ccctgtcccc gggt                                            1344


<210>  112
<211>  1344
<212>  DNA
<213>  artificial

<220>
<223>  heavy chain for #C01-SEED(AG) antibody 

<400>  112
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggggac cctgtccctc       60

acctgcgctg tctctggtgg ctccatcagc agtaataact ggtggagttg ggtccgccag      120

cccccaggga aggggctgga gtggattggg gaaatctatc atagtgggag caccagctac      180

aacccgtccc tcaagagtcg agtcaccata tcagtagaca agtccaagaa ccagttctcc      240

ctgaagctgt cctctgtgac cgccgcggac acggccgtgt attactgtgc gagagcgacc      300

gattggtttg acgcctgggg ccagggaacc ctggtcaccg tctcttcagc tagcaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac      660

aaaactcaca catgcccacc gtgcccagca cctgaactcc tgggggggcc ctcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctcta gaacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagccccc atcgagaaaa cgatatccaa agccaaaggg     1020

cagcccttcc ggccagaggt ccacctgctg cccccatcac gggaggagat gaccaagaac     1080

caggtcagcc tgacctgcct ggcacgcggc ttctatccca aggacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc cttcccggca ggagcccagc     1200

cagggcacca ccaccttcgc tgtgacctcg aagctcaccg tggacaagag cagatggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagaccatct ccctgtcccc gggt                                            1344


<210>  113
<211>  1344
<212>  DNA
<213>  artificial

<220>
<223>  heavy chain for #A07-SEED(AG) antibody 

<400>  113
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggggac cctgtccctc       60

acctgcgctg tctctggtgg ctccatcagc agtaataact ggtggagttg ggtccgccag      120

cccccaggga aggggctgga gtggattggg gaaatctatc atagtgggag caccagctac      180

aacccgtccc tcaagagtcg agtcaccata tcagtagaca agtccaagaa ccagttctcc      240

ctgaagctgt cctctgtgac cgccgcggac acggccgtgt attactgtgc gagaggtact      300

gactggtatg acccctgggg ccagggaacc ctggtcaccg tctcctcagc tagcaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac      660

aaaactcaca catgcccacc gtgcccagca cctgaactcc tgggggggcc ctcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctcta gaacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagccccc atcgagaaaa cgatatccaa agccaaaggg     1020

cagcccttcc ggccagaggt ccacctgctg cccccatcac gggaggagat gaccaagaac     1080

caggtcagcc tgacctgcct ggcacgcggc ttctatccca aggacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc cttcccggca ggagcccagc     1200

cagggcacca ccaccttcgc tgtgacctcg aagctcaccg tggacaagag cagatggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagaccatct ccctgtcccc gggt                                            1344



