                         SEQUENCE LISTING

<110>  LIU, Bin
       LEE, Nam-Kyung
       SU, Yang
       BIDLINGMAIER, Scott
 
<120>  ENGINEERED ANTIBODIES AND USES THEREOF

<130>  48536-594001WO

<140>  Not Yet Assigned
<141>  2017-11-17

<150>  62/424,337
<151>  2016-11-18

<160>  121   

<170>  PatentIn version 3.5

<210>  1
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence-E12N21 VH

<400>  1

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Thr Met Thr Ala Ser Ala Trp Leu Gly Gly Gly Arg Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  2
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence-E12N21 Linker

<400>  2

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  3
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence-E12N21 VL

<400>  3

Gln Ser Val Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Leu Ser Thr 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser Val Arg Gly 
                85                  90                  95      


Ser Arg Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  4
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N21

<400>  4

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Thr Met Thr Ala Ser Ala Trp Leu Gly Gly Gly Arg Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln 
    130                 135                 140                 


Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys 
145                 150                 155                 160 


Gln Gly Asp Ser Leu Arg Thr Leu Ser Thr Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Ser Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Asn Ser Asn Arg Pro 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala 
        195                 200                 205             


Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr 
    210                 215                 220                 


Cys Gln Ser Tyr Asp Asn Ser Val Arg Gly Ser Arg Val Phe Gly Thr 
225                 230                 235                 240 


Gly Thr Lys Leu Thr Val Leu 
                245         


<210>  5
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N21I VH

<400>  5

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Thr Met Thr Ala Ser Ala Trp Leu Gly Gly Gly Arg Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  6
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N21I VL

<400>  6

Gln Ser Val Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Leu Ser Thr 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser Val Arg Gly 
                85                  90                  95      


Ser Arg Val Phe Gly Thr Gly Thr Lys Leu Thr Ile Leu 
            100                 105                 


<210>  7
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N21I

<400>  7

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Thr Met Thr Ala Ser Ala Trp Leu Gly Gly Gly Arg Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln 
    130                 135                 140                 


Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys 
145                 150                 155                 160 


Gln Gly Asp Ser Leu Arg Thr Leu Ser Thr Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Ser Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Asn Ser Asn Arg Pro 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala 
        195                 200                 205             


Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr 
    210                 215                 220                 


Cys Gln Ser Tyr Asp Asn Ser Val Arg Gly Ser Arg Val Phe Gly Thr 
225                 230                 235                 240 


Gly Thr Lys Leu Thr Ile Leu 
                245         


<210>  8
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N7 VH

<400>  8

Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Val Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ile Gly Arg Val Gln Tyr Phe Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  9
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N7 VL

<400>  9

Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly 
1               5                   10                  15      


Gln Thr Val Thr Ile Ser Cys Thr Gly Ser Asn Ser Asp Ile Gly Ala 
            20                  25                  30          


Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Gly Asn His Gln Arg Pro Ser Gly Val Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly 
65                  70                  75                  80  


Val Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Gly Asn 
                85                  90                  95      


Ser Val Arg Gly Ser Arg Val Phe Gly Thr Gly Thr Lys Leu Thr Val 
            100                 105                 110         


Leu 
    


<210>  10
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N7

<400>  10

Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Val Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ile Gly Arg Val Gln Tyr Phe Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Ser Gln Ser Val Leu Thr Gln Pro Pro 
    130                 135                 140                 


Ser Val Ser Gly Ala Pro Gly Gln Thr Val Thr Ile Ser Cys Thr Gly 
145                 150                 155                 160 


Ser Asn Ser Asp Ile Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln 
                165                 170                 175     


Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly Asn His Gln Arg 
            180                 185                 190         


Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Thr Ser 
        195                 200                 205             


Ala Ser Leu Ala Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Gln Ser Tyr Gly Asn Ser Val Arg Gly Ser Arg Val Phe Gly 
225                 230                 235                 240 


Thr Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  11
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N12 VH

<400>  11

Gln Val Asn Leu Arg Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gln Phe Asn Trp Asn Tyr Ala Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  12
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N12 VL

<400>  12

Gln Ser Ala Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Asn Ser Tyr Ala 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Leu Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Ile Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Lys Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Gly 
                85                  90                  95      


Met Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  13
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N12

<400>  13

Gln Val Asn Leu Arg Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gln Phe Asn Trp Asn Tyr Ala Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr 
    130                 135                 140                 


Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr 
145                 150                 155                 160 


Cys Gln Gly Asp Ser Leu Arg Asn Ser Tyr Ala Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Ala Pro Leu Leu Val Ile Tyr Gly Lys Asn Ile Arg 
            180                 185                 190         


Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asp Thr 
        195                 200                 205             


Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Gly Met Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Thr Val Leu 
                245     


<210>  14
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N12EQV VH

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gln Phe Asn Trp Asn Tyr Ala Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  15
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N12EQV VL

<400>  15

Gln Ser Ala Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Asn Ser Tyr Ala 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Leu Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Ile Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Lys Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Gly 
                85                  90                  95      


Met Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  16
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N12EQV

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gln Phe Asn Trp Asn Tyr Ala Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr 
    130                 135                 140                 


Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr 
145                 150                 155                 160 


Cys Gln Gly Asp Ser Leu Arg Asn Ser Tyr Ala Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Ala Pro Leu Leu Val Ile Tyr Gly Lys Asn Ile Arg 
            180                 185                 190         


Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Asp Thr 
        195                 200                 205             


Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Gly Met Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Thr Val Leu 
                245     


<210>  17
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N13 VH

<400>  17

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Pro Arg Leu Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  18
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N13 VL

<400>  18

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ser Asp Ser Arg Pro Ala Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser 
                85                  90                  95      


Leu Ser Val Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  19
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N13

<400>  19

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Pro Arg Leu Tyr Tyr Tyr Tyr Tyr Met Asp Val Trp Gly 
            100                 105                 110         


Lys Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro 
    130                 135                 140                 


Ser Val Ser Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly 
145                 150                 155                 160 


Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln 
                165                 170                 175     


Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly Ser Asp Ser Arg 
            180                 185                 190         


Pro Ala Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser 
        195                 200                 205             


Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Gly Thr Trp Asp Ser Ser Leu Ser Val Val Val Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Leu Thr Val Leu 
                245         


<210>  20
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N1 VH

<400>  20

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Gly Gly Asp Pro Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Ser Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Lys Leu Thr Gly Asp Pro Ala Thr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Ser Thr Leu Val Thr Val Pro Ser 
        115                 120     


<210>  21
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N1 VL

<400>  21

Gln Ser Val Leu Thr Gln Pro Pro Ser Leu Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Leu Glu Asp Lys Tyr Ala 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Arg Asp Thr Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser Val Arg Gly 
                85                  90                  95      


Ser Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 


<210>  22
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N1

<400>  22

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Gly Gly Asp Pro Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Ser Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Lys Leu Thr Gly Asp Pro Ala Thr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Ser Thr Leu Val Thr Val Pro Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro 
    130                 135                 140                 


Ser Leu Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr Cys Ser Gly 
145                 150                 155                 160 


Asp Asn Leu Glu Asp Lys Tyr Ala Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ser Pro Val Leu Val Ile Tyr Arg Asp Thr Lys Arg Pro Ser Gly 
            180                 185                 190         


Ile Pro Glu Arg Phe Ser Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu 
        195                 200                 205             


Ala Ile Thr Gly Val Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln 
    210                 215                 220                 


Ser Tyr Asp Asn Ser Val Arg Gly Ser Arg Val Phe Gly Thr Gly Thr 
225                 230                 235                 240 


Lys Val Thr Val Leu 
                245 


<210>  23
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N11 VH

<400>  23

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Pro Val Phe Lys Ser Pro Ser Ile Ala Gly Leu Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  24
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N11 VL

<400>  24

Ser Tyr Val Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Asn Ser Tyr Ala 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Ala Lys Thr Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser Leu Arg Gly 
                85                  90                  95      


Ser Arg Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  25
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N11

<400>  25

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Pro Val Phe Lys Ser Pro Ser Ile Ala Gly Leu Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Tyr Val Leu Thr 
    130                 135                 140                 


Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr 
145                 150                 155                 160 


Cys Gln Gly Asp Ser Leu Arg Asn Ser Tyr Ala Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Ala Lys Thr Asn Arg 
            180                 185                 190         


Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr 
        195                 200                 205             


Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Gln Ser Tyr Asp Asn Ser Leu Arg Gly Ser Arg Val Phe Gly 
225                 230                 235                 240 


Thr Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  26
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N11R VH

<400>  26

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Arg 
                85                  90                  95      


Ala Lys Asp Pro Val Phe Lys Ser Pro Ser Ile Ala Gly Leu Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  27
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N11R VL

<400>  27

Ser Tyr Val Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Asn Ser Tyr Ala 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Ala Lys Thr Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser Leu Arg Gly 
                85                  90                  95      


Ser Arg Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  28
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N11R

<400>  28

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu His 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Arg 
                85                  90                  95      


Ala Lys Asp Pro Val Phe Lys Ser Pro Ser Ile Ala Gly Leu Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Tyr Val Leu Thr 
    130                 135                 140                 


Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr 
145                 150                 155                 160 


Cys Gln Gly Asp Ser Leu Arg Asn Ser Tyr Ala Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Ala Lys Thr Asn Arg 
            180                 185                 190         


Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr 
        195                 200                 205             


Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Gln Ser Tyr Asp Asn Ser Leu Arg Gly Ser Arg Val Phe Gly 
225                 230                 235                 240 


Thr Gly Thr Lys Leu Thr Val Leu 
                245             


<210>  29
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N35 VH

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Lys Pro Pro Gly Ile Ala Val Ala Gly Leu Phe Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  30
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N35 VL

<400>  30

Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
1               5                   10                  15      


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
        35                  40                  45              


Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
    50                  55                  60                  


Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Tyr Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  31
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N35

<400>  31

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Lys Pro Pro Gly Ile Ala Val Ala Gly Leu Phe Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro 
    130                 135                 140                 


Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly 
145                 150                 155                 160 


Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly 
            180                 185                 190         


Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu 
        195                 200                 205             


Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn 
    210                 215                 220                 


Ser Arg Asp Ser Ser Gly Asn Tyr Val Val Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  32
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N39 VH

<400>  32

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Pro Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Lys Pro Pro Gly Ile Ala Val Ala Gly Leu Leu Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  33
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N39 VL

<400>  33

Ser Glu Leu Thr His Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
1               5                   10                  15      


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
        35                  40                  45              


Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
    50                  55                  60                  


Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Tyr Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  34
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct - E12N39

<400>  34

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Pro Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Asn Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Lys Pro Pro Gly Ile Ala Val Ala Gly Leu Leu Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Leu Thr His Asp Pro 
    130                 135                 140                 


Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly 
145                 150                 155                 160 


Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly 
            180                 185                 190         


Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu 
        195                 200                 205             


Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn 
    210                 215                 220                 


Ser Arg Asp Ser Ser Gly Asn Tyr Val Val Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  35
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N45 VH

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Ser Ser Gly Trp Pro Arg Ala Glu Tyr Phe Gln His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  36
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N45 VL

<400>  36

Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Pro 
1               5                   10                  15      


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
        35                  40                  45              


Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
    50                  55                  60                  


Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Arg His 
                85                  90                  95      


Ser Asn Tyr Val Phe Gly Ile Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  37
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N45

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Ser Ser Gly Trp Pro Arg Ala Glu Tyr Phe Gln His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro 
    130                 135                 140                 


Ala Val Ser Val Ala Leu Gly Gln Pro Val Arg Ile Thr Cys Gln Gly 
145                 150                 155                 160 


Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly 
            180                 185                 190         


Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asp Thr Ala Ser Leu 
        195                 200                 205             


Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn 
    210                 215                 220                 


Ser Arg Asp Ser Ser Gly Asn Arg His Ser Asn Tyr Val Phe Gly Ile 
225                 230                 235                 240 


Gly Thr Lys Val Thr Val Leu 
                245         


<210>  38
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N45T VH

<400>  38

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Ser Ser Gly Trp Pro Arg Ala Glu Tyr Phe Gln His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  39
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N45T VL

<400>  39

Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Pro 
1               5                   10                  15      


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
        35                  40                  45              


Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
    50                  55                  60                  


Ser Gly Asp Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Arg His 
                85                  90                  95      


Ser Asn Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  40
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E12N45T

<400>  40

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Ser Ser Gly Trp Pro Arg Ala Glu Tyr Phe Gln His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro 
    130                 135                 140                 


Ala Val Ser Val Ala Leu Gly Gln Pro Val Arg Ile Thr Cys Gln Gly 
145                 150                 155                 160 


Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly 
            180                 185                 190         


Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asp Thr Ala Ser Leu 
        195                 200                 205             


Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn 
    210                 215                 220                 


Ser Arg Asp Ser Ser Gly Asn Arg His Ser Asn Tyr Val Phe Gly Thr 
225                 230                 235                 240 


Gly Thr Lys Val Thr Val Leu 
                245         


<210>  41
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N19 VH

<400>  41

Gln Val Asn Leu Arg Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Arg Gly His Gly Gly Asn Ser Gly Trp Val Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  42
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct - E34N19 VL

<400>  42

Gln Ser Val Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Lys Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Thr 
            20                  25                  30          


Ser Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Ile Leu Val Leu Tyr 
        35                  40                  45              


Ala Asn Thr His Arg Pro Ser Ser Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Tyr 
                85                  90                  95      


Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  43
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N19

<400>  43

Gln Val Asn Leu Arg Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Arg Gly His Gly Gly Asn Ser Gly Trp Val Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Asp 
    130                 135                 140                 


Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Lys Ile Thr Cys Gln 
145                 150                 155                 160 


Gly Asp Ser Leu Arg Thr Tyr Tyr Thr Ser Trp Tyr Gln Gln Arg Pro 
                165                 170                 175     


Gly Gln Ala Pro Ile Leu Val Leu Tyr Ala Asn Thr His Arg Pro Ser 
            180                 185                 190         


Ser Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Thr Thr Ala Ser 
        195                 200                 205             


Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Asn Ser Arg Asp Ser Ser Gly Asn Tyr Leu Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  44
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N19EQV VH

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Arg Gly His Gly Gly Asn Ser Gly Trp Val Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  45
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N19EQV VL

<400>  45

Gln Ser Val Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Lys Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Thr 
            20                  25                  30          


Ser Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Ile Leu Val Leu Tyr 
        35                  40                  45              


Ala Asn Thr His Arg Pro Ser Ser Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Tyr 
                85                  90                  95      


Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  46
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N19EQV

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Arg Gly His Gly Gly Asn Ser Gly Trp Val Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Asp 
    130                 135                 140                 


Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Lys Ile Thr Cys Gln 
145                 150                 155                 160 


Gly Asp Ser Leu Arg Thr Tyr Tyr Thr Ser Trp Tyr Gln Gln Arg Pro 
                165                 170                 175     


Gly Gln Ala Pro Ile Leu Val Leu Tyr Ala Asn Thr His Arg Pro Ser 
            180                 185                 190         


Ser Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Thr Thr Ala Ser 
        195                 200                 205             


Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Asn Ser Arg Asp Ser Ser Gly Asn Tyr Leu Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  47
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence  - E34N1 VH

<400>  47

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Met Ser Val Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Glu Tyr Tyr Tyr Asp Ser Ser Gly Tyr Tyr Asp Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  48
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N1 VL

<400>  48

Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
1               5                   10                  15      


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
        35                  40                  45              


Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
    50                  55                  60                  


Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Thr Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  49
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N1

<400>  49

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Met Ser Val Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Glu Tyr Tyr Tyr Asp Ser Ser Gly Tyr Tyr Asp Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
                165                 170                 175     


Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser 
    210                 215                 220                 


Arg Asp Ser Ser Gly Thr Val Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu 
        


<210>  50
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N2 VH

<400>  50

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Phe Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Gly Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Arg Tyr Ser Tyr Val Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  51
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N2 VL

<400>  51

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Asn 
                85                  90                  95      


Tyr Ser Trp Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  52
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N2

<400>  52

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Phe Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Gly Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Arg Tyr Ser Tyr Val Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser 
    130                 135                 140                 


Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val 
145                 150                 155                 160 


Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile 
        195                 200                 205             


Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr 
    210                 215                 220                 


Ala Gly Asn Tyr Ser Trp Ile Phe Gly Gly Gly Thr Lys Val Thr Val 
225                 230                 235                 240 


Leu 
    


<210>  53
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N3 VH

<400>  53

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Thr Pro Glu Gly Trp Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  54
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N3 VL

<400>  54

Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
1               5                   10                  15      


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Lys Ser Tyr Tyr Ala Ser 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
        35                  40                  45              


Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
    50                  55                  60                  


Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Leu 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  55
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N3

<400>  55

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Thr Pro Glu Gly Trp Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val 
    130                 135                 140                 


Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Lys 
145                 150                 155                 160 


Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
                165                 170                 175     


Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg 
            180                 185                 190         


Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly 
        195                 200                 205             


Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser 
    210                 215                 220                 


Ser Gly Asn His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235                 240 


<210>  56
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N4 VH

<400>  56

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Tyr Asp Val Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  57
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N4 VL

<400>  57

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  58
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N4

<400>  58

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Tyr Asp Val Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
    130                 135                 140                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile 
145                 150                 155                 160 


Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
                165                 170                 175     


Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
            180                 185                 190         


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
        195                 200                 205             


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser 
    210                 215                 220                 


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235             


<210>  59
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N5 VH

<400>  59

Gln Val Gln Leu Leu Gln Ser Ala Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Glu Asp Tyr Pro Tyr Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  60
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N5 VL

<400>  60

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Val Gly Ala Gly 
            20                  25                  30          


Phe Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asp Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  61
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N5

<400>  61

Gln Val Gln Leu Leu Gln Ser Ala Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Glu Asp Tyr Pro Tyr Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser 
    130                 135                 140                 


Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser 
145                 150                 155                 160 


Asn Val Gly Ala Gly Phe Asp Val His Trp Tyr Gln Gln Leu Pro Gly 
                165                 170                 175     


Thr Ala Pro Lys Leu Leu Ile Tyr Gly Asp Asn Asn Arg Pro Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu 
        195                 200                 205             


Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln 
    210                 215                 220                 


Ser Tyr Asp Ser Ser Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Thr Val Leu 
                


<210>  62
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N6 VH

<400>  62

Gln Val Gln Leu Leu Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Gly Pro Ser Gly Ser Ser Thr Tyr Tyr Ala Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Tyr Lys Asn Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Lys Glu Gly Pro Asn Ser Gly Tyr Phe Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  63
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N6 VL

<400>  63

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Ile Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  64
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N6

<400>  64

Gln Val Gln Leu Leu Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Gly Pro Ser Gly Ser Ser Thr Tyr Tyr Ala Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Tyr Lys Asn Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Lys Glu Gly Pro Asn Ser Gly Tyr Phe Asp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Val Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Ile Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys 
                245 


<210>  65
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N7 VH

<400>  65

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Ser Ser Ser Tyr Pro Ile Ala Ala Arg Arg Tyr Tyr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  66
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N7 VL

<400>  66

Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Asn Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Phe Val Ser Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Phe Asp Val Ser Asp Arg Pro Ser Arg Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Asn 
                85                  90                  95      


Asn Asn Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  67
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N7

<400>  67

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Ser Ser Ser Tyr Pro Ile Ala Ala Arg Arg Tyr Tyr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser 
145                 150                 155                 160 


Ile Thr Ile Ser Cys Thr Gly Thr Asn Ser Asp Val Gly Gly Tyr Asn 
                165                 170                 175     


Phe Val Ser Trp Tyr Gln Gln Tyr Pro Gly Lys Ala Pro Lys Leu Ile 
            180                 185                 190         


Ile Phe Asp Val Ser Asp Arg Pro Ser Arg Val Ser Asn Arg Phe Ser 
        195                 200                 205             


Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln 
    210                 215                 220                 


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Asn Asn 
225                 230                 235                 240 


Asn Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250             


<210>  68
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N8 VH

<400>  68

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Tyr Tyr Asp Phe Trp Ser Gly Tyr Pro Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  69
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N8 VL

<400>  69

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Gly Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Thr Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  70
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N8

<400>  70

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Gly Ser Gly Tyr Thr Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Tyr Tyr Asp Phe Trp Ser Gly Tyr Pro Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Thr Ile Gly Ser Trp Leu Ala Trp Tyr Gln Gln Thr 
                165                 170                 175     


Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Glu 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Glu Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Tyr Asn Ser Tyr Pro Arg Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  71
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N9 VH

<400>  71

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Ser Gly Tyr Ser Tyr Gly Tyr Val Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  72
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N9 VL

<400>  72

Ser Glu Leu Thr Gln Asp Pro Ala Met Ser Val Ala Leu Gly Gln Thr 
1               5                   10                  15      


Val Asn Ile Thr Cys Gln Gly Asp Ser Leu Arg Arg Tyr Phe Pro Ser 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Leu Tyr Gly 
        35                  40                  45              


Arg Asn Thr Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Asn 
    50                  55                  60                  


Ser Gly Asn Ser Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys His Ser Arg Gly Ser Ser Gly Thr His Leu 
                85                  90                  95      


Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  73
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N9

<400>  73

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Ser Gly Tyr Ser Tyr Gly Tyr Val Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala 
    130                 135                 140                 


Met Ser Val Ala Leu Gly Gln Thr Val Asn Ile Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Arg Tyr Phe Pro Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
                165                 170                 175     


Ala Pro Val Leu Val Leu Tyr Gly Arg Asn Thr Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Asn Ser Gly Asn Ser Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys His Ser 
    210                 215                 220                 


Arg Gly Ser Ser Gly Thr His Leu Arg Val Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  74
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N11 VH

<400>  74

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Gly Ser Thr Tyr Ile Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Gly Ala Ser Asn Trp Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  75
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N11 VL

<400>  75

Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
1               5                   10                  15      


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Phe Asp Ala Ser 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Tyr Gly 
        35                  40                  45              


Glu Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
    50                  55                  60                  


Ser Gly Asn Ser Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Ser Arg Gly Asn His Leu 
                85                  90                  95      


Ala Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  76
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N11

<400>  76

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Gly Ser Thr Tyr Ile Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Gly Ala Ser Asn Trp Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val 
    130                 135                 140                 


Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser 
145                 150                 155                 160 


Leu Arg Ser Phe Asp Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
                165                 170                 175     


Pro Val Val Val Ile Tyr Gly Glu Asn Asn Arg Pro Ser Gly Ile Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Ser Ala Ser Leu Thr Ile 
        195                 200                 205             


Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg 
    210                 215                 220                 


Asp Ser Arg Gly Asn His Leu Ala Leu Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Thr Val Leu 
            


<210>  77
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N12 VH

<400>  77

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Met Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Arg Ala Lys Ile Ala Ala Arg Ala Gln Gly Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser 
        115                 120                 


<210>  78
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N12 VL

<400>  78

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Thr Ser Ser 
                85                  90                  95      


Thr Leu Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 


<210>  79
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N12

<400>  79

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Met Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Arg Ala Lys Ile Ala Ala Arg Ala Gln Gly Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr 
    130                 135                 140                 


Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln Lys Val Thr Ile Ser 
145                 150                 155                 160 


Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser Trp Tyr 
                165                 170                 175     


Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Asp Asn Asn 
            180                 185                 190         


Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly 
        195                 200                 205             


Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala 
    210                 215                 220                 


Asp Tyr Tyr Cys Ser Ser Tyr Thr Thr Ser Ser Thr Leu Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Thr Val Leu 
                245             


<210>  80
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N13 VH

<400>  80

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Lys Arg Gly Glu Tyr Ser Ser Gly Trp Tyr Gly Pro Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  81
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N13 VL

<400>  81

Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  82
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N13

<400>  82

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Lys Arg Gly Glu Tyr Ser Ser Gly Trp Tyr Gly Pro Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Tyr Val Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Val Ser Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys 
145                 150                 155                 160 


Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His Trp Tyr 
                165                 170                 175     


Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly Asn Ser 
            180                 185                 190         


Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly 
        195                 200                 205             


Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala 
    210                 215                 220                 


Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Val Thr Val Leu 
                245                 


<210>  83
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N14 VH

<400>  83

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Val Pro Gly Thr Pro Pro Ala Glu Tyr Phe Gln His 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  84
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N14 VL

<400>  84

Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
1               5                   10                  15      


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Lys Ser Tyr Tyr Ala Ser 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
        35                  40                  45              


Glu Asn Ser Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
    50                  55                  60                  


Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys His Ser Arg Asp Ser Ser Gly Thr His Leu 
                85                  90                  95      


Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105             


<210>  85
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N14

<400>  85

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Val Pro Gly Thr Pro Pro Ala Glu Tyr Phe Gln His 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp 
    130                 135                 140                 


Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln 
145                 150                 155                 160 


Gly Asp Ser Leu Lys Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Glu Asn Ser Arg Pro Ser 
            180                 185                 190         


Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser 
        195                 200                 205             


Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


His Ser Arg Asp Ser Ser Gly Thr His Leu Arg Val Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Thr Val Leu 
                245     


<210>  86
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N14M VH

<400>  86

Gln Met Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Val Pro Gly Thr Pro Pro Ala Glu Tyr Phe Gln His 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  87
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N14M VL

<400>  87

Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
1               5                   10                  15      


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Lys Ser Tyr Tyr Ala Ser 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
        35                  40                  45              


Glu Asn Ser Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
    50                  55                  60                  


Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys His Ser Arg Asp Ser Ser Gly Thr His Leu 
                85                  90                  95      


Arg Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105             


<210>  88
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N14M

<400>  88

Gln Met Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Val Pro Gly Thr Pro Pro Ala Glu Tyr Phe Gln His 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Leu Thr Gln Asp 
    130                 135                 140                 


Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln 
145                 150                 155                 160 


Gly Asp Ser Leu Lys Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Glu Asn Ser Arg Pro Ser 
            180                 185                 190         


Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser 
        195                 200                 205             


Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


His Ser Arg Asp Ser Ser Gly Thr His Leu Arg Val Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Thr Val Leu 
                245     


<210>  89
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N15 VH

<400>  89

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Gly Gly Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Ser Thr Ala Asp Ala Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Pro Val Gly Gly Ile Leu His Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  90
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N15 VL

<400>  90

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Pro Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ser Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Ser Phe Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Leu Val Thr Val Leu 
            100                 105         


<210>  91
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N15

<400>  91

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Gly Gly Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Ser Thr Ala Asp Ala Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Pro Val Gly Gly Ile Leu His Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Arg Ala Pro Lys Leu Leu Ile His Pro Ala Ser Thr Leu Gln Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Ala Ser Gly Phe Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Thr Ser Leu Gln Pro Glu Asp Ser Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Leu Gln Asp Tyr Asn Ser Phe Thr Phe Gly Pro Gly Thr Lys Leu Val 
225                 230                 235                 240 


Thr Val Leu 
            


<210>  92
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N20 VH

<400>  92

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Asn Lys Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Gly Asp Gly Tyr Asn Ser Gly Trp Tyr Ser Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  93
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N20 VL

<400>  93

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Val Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  94
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N20

<400>  94

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Asn Lys Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Gly Asp Gly Tyr Asn Ser Gly Trp Tyr Ser Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Val Ser Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys 
145                 150                 155                 160 


Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His Trp Tyr 
                165                 170                 175     


Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly Asn Ser 
            180                 185                 190         


Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly 
        195                 200                 205             


Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala 
    210                 215                 220                 


Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu Ser Val Val Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Val Thr Val Leu 
                245                 


<210>  95
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N22 VH

<400>  95

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Leu Trp Arg Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  96
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N22 VL

<400>  96

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ala Asp Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Leu Ala Glu Asp Glu Ala Asp Tyr Phe Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Ser Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  97
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N22

<400>  97

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Leu Trp Arg Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser 
    130                 135                 140                 


Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser 
145                 150                 155                 160 


Asn Ile Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly 
                165                 170                 175     


Thr Ala Pro Lys Leu Leu Ile Tyr Ala Asp Ser Asn Arg Pro Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu 
        195                 200                 205             


Ala Ile Thr Gly Leu Leu Ala Glu Asp Glu Ala Asp Tyr Phe Cys Gln 
    210                 215                 220                 


Ser Tyr Asp Ser Ser Leu Ser Ser Val Val Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Thr Val Leu 
                


<210>  98
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N26C VH

<400>  98

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Arg Gly Asn Tyr Val Ser Asn Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  99
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N26C VL

<400>  99

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Lys Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Asp Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Arg Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Asn Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  100
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N26C

<400>  100

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Arg Gly Asn Tyr Val Ser Asn Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro 
    130                 135                 140                 


Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr 
145                 150                 155                 160 


Gly Thr Ser Ser Asp Val Gly Gly Tyr Lys Tyr Val Ser Trp Tyr Gln 
                165                 170                 175     


Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Val Ser Gln 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Asp Asn 
        195                 200                 205             


Thr Ala Ser Leu Thr Val Ser Gly Leu Arg Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser Asn Asn Trp Val Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Thr Val Leu 
                245         


<210>  101
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N26R VH

<400>  101

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Arg Gly Asn Tyr Val Ser Asn Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  102
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N26R VL

<400>  102

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Lys Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Asp Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Arg Ala Glu Asp Glu Ala Asp Tyr Tyr Arg Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Asn Asn Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  103
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - E34N26R

<400>  103

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Arg Gly Asn Tyr Val Ser Asn Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro 
    130                 135                 140                 


Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr 
145                 150                 155                 160 


Gly Thr Ser Ser Asp Val Gly Gly Tyr Lys Tyr Val Ser Trp Tyr Gln 
                165                 170                 175     


Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Val Ser Gln 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Asp Asn 
        195                 200                 205             


Thr Ala Ser Leu Thr Val Ser Gly Leu Arg Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Arg Ser Ser Tyr Ala Gly Ser Asn Asn Trp Val Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Thr Val Leu 
                245         


<210>  104
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - H3 VH

<400>  104

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  105
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - H3 VL

<400>  105

Asn Phe Met Leu Thr Gln Asn Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Leu Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Pro 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105         


<210>  106
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - H3

<400>  106

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asn Phe Met Leu Thr Gln Asn Pro Ala Val Ser Val Ala Leu 
    130                 135                 140                 


Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr 
145                 150                 155                 160 


Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Leu Leu Val 
                165                 170                 175     


Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
            180                 185                 190         


Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln 
        195                 200                 205             


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly 
    210                 215                 220                 


Asn Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
225                 230                 235         


<210>  107
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - 58541 (H3 variant1) VH

<400>  107

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  108
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - 58541 (H3 variant1) VL

<400>  108

Asn Phe Met Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Leu Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Pro 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105         


<210>  109
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - 58541 (H3 variant1)

<400>  109

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asn Phe Met Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu 
    130                 135                 140                 


Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr 
145                 150                 155                 160 


Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Leu Leu Val 
                165                 170                 175     


Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
            180                 185                 190         


Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln 
        195                 200                 205             


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly 
    210                 215                 220                 


Asn Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
225                 230                 235         


<210>  110
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - 58541.1 (H3 variant2) VH

<400>  110

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  111
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - 58541.1 (H3 variant2) VL

<400>  111

Asn Phe Met Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Leu Leu Val Ile Tyr 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Pro 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105         


<210>  112
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - 58541.1 (H3 variant2)

<400>  112

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Ser Leu Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asn Phe Met Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu 
    130                 135                 140                 


Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr 
145                 150                 155                 160 


Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Leu Leu Val 
                165                 170                 175     


Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
            180                 185                 190         


Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln 
        195                 200                 205             


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly 
    210                 215                 220                 


Asn Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
225                 230                 235         


<210>  113
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - PD32 VH

<400>  113

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Leu Ile Ala Ser His Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  114
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - PD32 VL

<400>  114

Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
1               5                   10                  15      


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly 
        35                  40                  45              


Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
    50                  55                  60                  


Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Ile His Leu 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  115
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - PD32

<400>  115

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Leu Ile Ala Ser His Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly 
    130                 135                 140                 


Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr 
145                 150                 155                 160 


Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile 
                165                 170                 175     


Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly 
            180                 185                 190         


Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala 
        195                 200                 205             


Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Ile 
    210                 215                 220                 


His Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
225                 230                 235         


<210>  116
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - M10A12 VH

<400>  116

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Tyr Ser Ser Asn Trp Phe Ser Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  117
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - M10A12 VL

<400>  117

Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr 
1               5                   10                  15      


Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Leu Leu Val Ile Tyr Gly 
        35                  40                  45              


Glu Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser 
    50                  55                  60                  


Ser Gly Asn Thr Ala Phe Leu Thr Ile Ser Arg Val Glu Ala Gly Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His Pro 
                85                  90                  95      


Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 


<210>  118
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - M10A12

<400>  118

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Arg Tyr Ser Ser Asn Trp Phe Ser Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu 
    130                 135                 140                 


Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg 
145                 150                 155                 160 


Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Leu Leu Val Ile Tyr Gly Glu Asn 
            180                 185                 190         


Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
        195                 200                 205             


Asn Thr Ala Phe Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala 
    210                 215                 220                 


Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His Pro Gly Val 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
                245                 250     


<210>  119
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - RYR VH

<400>  119

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Arg Leu Pro Asp Phe Trp Ser Gly Tyr Pro Asn Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  120
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - RYR VL

<400>  120

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  121
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence - RYR

<400>  121

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Arg Leu Pro Asp Phe Trp Ser Gly Tyr Pro Asn Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val 
    130                 135                 140                 


Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln Arg Val Thr 
145                 150                 155                 160 


Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val 
                165                 170                 175     


His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala Glu 
    210                 215                 220                 


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu Ser Gly 
225                 230                 235                 240 


His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 250             


