                         SEQUENCE LISTING

<110>  Kaspar, Brian et al.
 
<120>  INTRATHECAL DELIVERY OF RECOMBINANT ADENO-ASSOCIATED VIRUS 
       ENCODING METHYL-CPG BINDING PROTEIN 2

<130>  28335/50215PCT

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  2558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<223>  AVXS-201 genome

<220>
<221>  misc_feature
<222>  (1)..(106)
<223>  mutated ITR

<220>
<221>  misc_feature
<222>  (151)..(699)
<223>  546 promoter fragment

<220>
<221>  misc_feature
<222>  (729)..(827)
<223>  SV40 intron

<220>
<221>  misc_feature
<222>  (848)..(2344)
<223>  hMECP2B cds

<220>
<221>  misc_feature
<222>  (2345)..(2393)
<223>  synthetic pA

<220>
<221>  misc_feature
<222>  (2418)..(2558)
<223>  ITR

<400>  1
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggaatt cacgcgtgga      120

tctgaattca attcacgcgt ggtaccacgc gtgaacaacg ccaggctcct caacaggcaa      180

ctttgctact tctacagaaa atgataataa agaaatgctg gtgaagtcaa atgcttatca      240

caatggtgaa ctactcagca gggaggctct aataggcgcc aagagcctag acttccttaa      300

gcgccagagt ccacaagggc ccagttaatc ctcaacattc aaatgctgcc cacaaaacca      360

gcccctctgt gccctagccg cctctttttt ccaagtgaca gtagaactcc accaatccgc      420

agctgaatgg ggtccgcctc ttttccctgc ctaaacagac aggaactcct gccaattgag      480

ggcgtcaccg ctaaggctcc gccccagcct gggctccaca accaatgaag ggtaatctcg      540

acaaagagca aggggtgggg cgcgggcgcg caggtgcagc agcacacagg ctggtcggga      600

gggcggggcg cgacgtctgc cgtgcggggt cccggcatcg gttgcgcgcg cgctccctcc      660

tctcggagag agggctgtgg taaaacccgt ccggaaaacg cgtcgaaggg cgaattctgc      720

agataactgg taagtttagt cttttttgtc ttttatttca ggtcccggat ccggtggtgg      780

tgcaaatcaa agaactgctc ctcagtcgat gttgccttta cttctaggcc tgtacggaag      840

tgttactatg gccgccgccg ccgccgccgc gccgagcgga ggaggaggag gaggcgagga      900

ggagagactg gaagaaaagt cagaagacca ggacctccag ggcctcaagg acaaacccct      960

caagtttaaa aaggtgaaga aagataagaa agaagagaaa gagggcaagc atgagcccgt     1020

gcagccatca gcccaccact ctgctgagcc cgcagaggca ggcaaagcag agacatcaga     1080

agggtcaggc tccgccccgg ctgtgccgga agcttctgcc tcccccaaac agcggcgctc     1140

catcatccgt gaccggggac ccatgtatga tgaccccacc ctgcctgaag gctggacacg     1200

gaagcttaag caaaggaaat ctggccgctc tgctgggaag tatgatgtgt atttgatcaa     1260

tccccaggga aaagcctttc gctctaaagt ggagttgatt gcgtacttcg aaaaggtagg     1320

cgacacatcc ctggacccta atgattttga cttcacggta actgggagag ggagcccctc     1380

ccggcgagag cagaaaccac ctaagaagcc caaatctccc aaagctccag gaactggcag     1440

aggccgggga cgccccaaag ggagcggcac cacgagaccc aaggcggcca cgtcagaggg     1500

tgtgcaggtg aaaagggtcc tggagaaaag tcctgggaag ctccttgtca agatgccttt     1560

tcaaacttcg ccagggggca aggctgaggg gggtggggcc accacatcca cccaggtcat     1620

ggtgatcaaa cgccccggca ggaagcgaaa agctgaggcc gaccctcagg ccattcccaa     1680

gaaacggggc cgaaagccgg ggagtgtggt ggcagccgct gccgccgagg ccaaaaagaa     1740

agccgtgaag gagtcttcta tccgatctgt gcaggagacc gtactcccca tcaagaagcg     1800

caagacccgg gagacggtca gcatcgaggt caaggaagtg gtgaagcccc tgctggtgtc     1860

caccctcggt gagaagagcg ggaaaggact gaagacctgt aagagccctg ggcggaaaag     1920

caaggagagc agccccaagg ggcgcagcag cagcgcctcc tcacccccca agaaggagca     1980

ccaccaccat caccaccact cagagtcccc aaaggccccc gtgccactgc tcccacccct     2040

gcccccacct ccacctgagc ccgagagctc cgaggacccc accagccccc ctgagcccca     2100

ggacttgagc agcagcgtct gcaaagagga gaagatgccc agaggaggct cactggagag     2160

cgacggctgc cccaaggagc cagctaagac tcagcccgcg gttgccaccg ccgccacggc     2220

cgcagaaaag tacaaacacc gaggggaggg agagcgcaaa gacattgttt catcctccat     2280

gccaaggcca aacagagagg agcctgtgga cagccggacg cccgtgaccg agagagttag     2340

ctgaaataaa agatctttat tttcattaga tctgtgtgtt ggttttttgt gtggcatgct     2400

ggggagagat cgatctgagg aacccctagt gatggagttg gccactccct ctctgcgcgc     2460

tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc     2520

ggcctcagtg agcgagcgag cgcgcagaga gggagtgg                             2558


<210>  2
<211>  549
<212>  DNA
<213>  Mus musculus

<400>  2
gtgaacaacg ccaggctcct caacaggcaa ctttgctact tctacagaaa atgataataa       60

agaaatgctg gtgaagtcaa atgcttatca caatggtgaa ctactcagca gggaggctct      120

aataggcgcc aagagcctag acttccttaa gcgccagagt ccacaagggc ccagttaatc      180

ctcaacattc aaatgctgcc cacaaaacca gcccctctgt gccctagccg cctctttttt      240

ccaagtgaca gtagaactcc accaatccgc agctgaatgg ggtccgcctc ttttccctgc      300

ctaaacagac aggaactcct gccaattgag ggcgtcaccg ctaaggctcc gccccagcct      360

gggctccaca accaatgaag ggtaatctcg acaaagagca aggggtgggg cgcgggcgcg      420

caggtgcagc agcacacagg ctggtcggga gggcggggcg cgacgtctgc cgtgcggggt      480

cccggcatcg gttgcgcgcg cgctccctcc tctcggagag agggctgtgg taaaacccgt      540

ccggaaaac                                                              549


<210>  3
<211>  1497
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  MeCP2B cds

<400>  3
atggccgccg ccgccgccgc cgcgccgagc ggaggaggag gaggaggcga ggaggagaga       60

ctggaagaaa agtcagaaga ccaggacctc cagggcctca aggacaaacc cctcaagttt      120

aaaaaggtga agaaagataa gaaagaagag aaagagggca agcatgagcc cgtgcagcca      180

tcagcccacc actctgctga gcccgcagag gcaggcaaag cagagacatc agaagggtca      240

ggctccgccc cggctgtgcc ggaagcttct gcctccccca aacagcggcg ctccatcatc      300

cgtgaccggg gacccatgta tgatgacccc accctgcctg aaggctggac acggaagctt      360

aagcaaagga aatctggccg ctctgctggg aagtatgatg tgtatttgat caatccccag      420

ggaaaagcct ttcgctctaa agtggagttg attgcgtact tcgaaaaggt aggcgacaca      480

tccctggacc ctaatgattt tgacttcacg gtaactggga gagggagccc ctcccggcga      540

gagcagaaac cacctaagaa gcccaaatct cccaaagctc caggaactgg cagaggccgg      600

ggacgcccca aagggagcgg caccacgaga cccaaggcgg ccacgtcaga gggtgtgcag      660

gtgaaaaggg tcctggagaa aagtcctggg aagctccttg tcaagatgcc ttttcaaact      720

tcgccagggg gcaaggctga ggggggtggg gccaccacat ccacccaggt catggtgatc      780

aaacgccccg gcaggaagcg aaaagctgag gccgaccctc aggccattcc caagaaacgg      840

ggccgaaagc cggggagtgt ggtggcagcc gctgccgccg aggccaaaaa gaaagccgtg      900

aaggagtctt ctatccgatc tgtgcaggag accgtactcc ccatcaagaa gcgcaagacc      960

cgggagacgg tcagcatcga ggtcaaggaa gtggtgaagc ccctgctggt gtccaccctc     1020

ggtgagaaga gcgggaaagg actgaagacc tgtaagagcc ctgggcggaa aagcaaggag     1080

agcagcccca aggggcgcag cagcagcgcc tcctcacccc ccaagaagga gcaccaccac     1140

catcaccacc actcagagtc cccaaaggcc cccgtgccac tgctcccacc cctgccccca     1200

cctccacctg agcccgagag ctccgaggac cccaccagcc cccctgagcc ccaggacttg     1260

agcagcagcg tctgcaaaga ggagaagatg cccagaggag gctcactgga gagcgacggc     1320

tgccccaagg agccagctaa gactcagccc gcggttgcca ccgccgccac ggccgcagaa     1380

aagtacaaac accgagggga gggagagcgc aaagacattg tttcatcctc catgccaagg     1440

ccaaacagag aggagcctgt ggacagccgg acgcccgtga ccgagagagt tagctga        1497


<210>  4
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<223>  Poly A sequence

<400>  4
aataaaagat ctttattttc attagatctg tgtgttggtt ttttgtgtg                   49


<210>  5
<211>  3093
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<223>  scAAV9.738.Mecp1 genome

<220>
<221>  misc_feature
<222>  (1)..(106)
<223>  mutated ITR

<220>
<221>  misc_feature
<222>  (198)..(936)
<223>  738 promoter fragment

<220>
<221>  misc_feature
<222>  (941)..(1037)
<223>  SV40 intron

<220>
<221>  misc_feature
<222>  (1138)..(2643)
<223>  MeCP2 cds

<220>
<221>  misc_feature
<222>  (2709)..(2890)
<223>  BGHpA

<220>
<221>  misc_feature
<222>  (2953)..(3093)
<223>  ITR

<400>  5
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggaatt cacgcgtgga      120

tctgaattca attcacgcgt ggtaccgagc tcggatccac tagtaacggc cgccagtgtg      180

ctggaattcg cccttaatat caaaccatct gattcaacaa tgacagaccg atctcttatg      240

ggcttggcac acaccatctg cccattataa acgtctgcaa agaccaaggt ttgatatgtt      300

gattttactg tcagccttaa gagtgcgaca tctgctaatt tagtgtaata atacaatcag      360

tagacccttt aaaacaagtc ccttggcttg gaacaacgcc aggctcctca acaggcaact      420

ttgctacttc tacagaaaat gataataaag aaatgctggt gaagtcaaat gcttatcaca      480

atggtgaact actcagcagg gaggctctaa taggcgccaa gagcctagac ttccttaagc      540

gccagagtcc acaagggccc agttaatcct caacattcaa atgctgccca caaaaccagc      600

ccctctgtgc cctagccgcc tcttttttcc aagtgacagt agaactccac caatccgcag      660

ctgaatgggg tccgcctctt ttccctgcct aaacagacag gaactcctgc caattgaggg      720

cgtcaccgct aaggctccgc cccagcctgg gctccacaac caatgaaggg taatctcgac      780

aaagagcaag gggtggggcg cgggcgcgca ggtgcagcag cacacaggct ggtcgggagg      840

gcggggcgcg acgtctgccg tgcggggtcc cggcatcggt tgcgcgcgcg ctccctcctc      900

tcggagagag ggctgtggta aaacccgtcc ggaaaaactg gtaagtttag tctttttgtc      960

ttttatttca ggtcccggat ccggtggtgg tgcaaatcaa agaactgctc ctcagtggat     1020

gttgccttta cttctaggcc tgtacggaag tgttacttct gctctaaaag ctgcggaatt     1080

gtacccgcgg ccgatccacc ggttttaagg gccgaggcgg ccagatcttt cgaagatatg     1140

gccgccgctg ccgccaccgc cgccgccgcc gccgcgccga gcggaggagg aggaggaggc     1200

gaggaggaga gactggagga aaagtcagaa gaccaggatc tccagggcct cagagacaag     1260

ccactgaagt ttaagaaggc gaagaaagac aagaaggagg acaaagaagg caagcatgag     1320

ccactacaac cttcagccca ccattctgca gagccagcag aggcaggcaa agcagaaaca     1380

tcagaaagct caggctctgc cccagcagtg ccagaagcct cggcttcccc caaacagcgg     1440

cgctccatta tccgtgaccg gggacctatg tatgatgacc ccaccttgcc tgaaggttgg     1500

acacgaaagc ttaaacaaag gaagtctggc cgatctgctg gaaagtatga tgtatatttg     1560

atcaatcccc agggaaaagc ttttcgctct aaagtagaat tgattgcata ctttgaaaag     1620

gtgggagaca cctccttgga ccctaatgat tttgacttca cggtaactgg gagagggagc     1680

ccctccagga gagagcagaa accacctaag aagcccaaat ctcccaaagc tccaggaact     1740

ggcaggggtc ggggacgccc caaagggagc ggcactggga gaccaaaggc agcagcatca     1800

gaaggtgttc aggtgaaaag ggtcctggag aagagccctg ggaaacttgt tgtcaagatg     1860

cctttccaag catcgcctgg gggtaagggt gagggaggtg gggctaccac atctgcccag     1920

gtcatggtga tcaaacgccc tggcagaaag cgaaaagctg aagctgaccc ccaggccatt     1980

cctaagaaac ggggtagaaa gcctgggagt gtggtggcag ctgctgcagc tgaggccaaa     2040

aagaaagccg tgaaggagtc ttccatacgg tctgtgcatg agactgtgct ccccatcaag     2100

aagcgcaaga cccgggagac ggtcagcatc gaggtcaagg aagtggtgaa gcccctgctg     2160

gtgtccaccc ttggtgagaa aagcgggaag ggactgaaga cctgcaagag ccctgggcgt     2220

aaaagcaagg agagcagccc caaggggcgc agcagcagtg cctcctcccc acctaagaag     2280

gagcaccatc atcaccacca tcactcagag tccacaaagg cccccatgcc actgctccca     2340

tccccacccc cacctgagcc tgagagctct gaggacccca tcagcccccc tgagcctcag     2400

gacttgagca gcagcatctg caaagaagag aagatgcccc gaggaggctc actggaaagc     2460

gatggctgcc ccaaggagcc agctaagact cagcctatgg tcgccaccac taccacagtt     2520

gcagaaaagt acaaacaccg aggggaggga gagcgcaaag acattgtttc atcttccatg     2580

ccaaggccaa acagagagga gcctgtggac agccggacgc ccgtgaccga gagagttagc     2640

tgaatcggcg ccgctagcgc ggccgcgttt aaaccctgca ggtctagaaa gcttatcgat     2700

accgtcgact agagctcgct gatcagcctc gactgtgcct tctagttgcc agccatctgt     2760

tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc     2820

ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg     2880

tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc atgctgggga     2940

gagatcgatc tgaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     3000

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct     3060

cagtgagcga gcgagcgcgc agagagggag tgg                                  3093


<210>  6
<211>  739
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  MECP2 promoter

<400>  6
tatcaaacca tctgattcaa caatgacaga ccgatctctt atgggcttgg cacacaccat       60

ctgcccatta taaacgtctg caaagaccaa ggtttgatat gttgatttta ctgtcagcct      120

taagagtgcg acatctgcta atttagtgta ataatacaat cagtagaccc tttaaaacaa      180

gtcccttggc ttggaacaac gccaggctcc tcaacaggca actttgctac ttctacagaa      240

aatgataata aagaaatgct ggtgaagtca aatgcttatc acaatggtga actactcagc      300

agggaggctc taataggcgc caagagccta gacttcctta agcgccagag tccacaaggg      360

cccagttaat cctcaacatt caaatgctgc ccacaaaacc agcccctctg tgccctagcc      420

gcctcttttt tccaagtgac agtagaactc caccaatccg cagctgaatg gggtccgcct      480

cttttccctg cctaaacaga caggaactcc tgccaattga gggcgtcacc gctaaggctc      540

cgccccagcc tgggctccac aaccaatgaa gggtaatctc gacaaagagc aaggggtggg      600

gcgcgggcgc gcaggtgcag cagcacacag gctggtcggg agggcggggc gcgacgtctg      660

ccgtgcgggg tcccggcatc ggttgcgcgc gcgctccctc ctctcggaga gagggctgtg      720

gtaaaacccg tccggaaaa                                                   739


<210>  7
<211>  1563
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  MECP2alpha

<400>  7
gtacccgcgg ccgatccacc ggttttaagg gccgaggcgg ccagatcttt cgaagatatg       60

gccgccgctg ccgccaccgc cgccgccgcc gccgcgccga gcggaggagg aggaggaggc      120

gaggaggaga gactggagga aaagtcagaa gaccaggatc tccagggcct cagagacaag      180

ccactgaagt ttaagaaggc gaagaaagac aagaaggagg acaaagaagg caagcatgag      240

ccactacaac cttcagccca ccattctgca gagccagcag aggcaggcaa agcagaaaca      300

tcagaaagct caggctctgc cccagcagtg ccagaagcct cggcttcccc caaacagcgg      360

cgctccatta tccgtgaccg gggacctatg tatgatgacc ccaccttgcc tgaaggttgg      420

acacgaaagc ttaaacaaag gaagtctggc cgatctgctg gaaagtatga tgtatatttg      480

atcaatcccc agggaaaagc ttttcgctct aaagtagaat tgattgcata ctttgaaaag      540

gtgggagaca cctccttgga ccctaatgat tttgacttca cggtaactgg gagagggagc      600

ccctccagga gagagcagaa accacctaag aagcccaaat ctcccaaagc tccaggaact      660

ggcaggggtc ggggacgccc caaagggagc ggcactggga gaccaaaggc agcagcatca      720

gaaggtgttc aggtgaaaag ggtcctggag aagagccctg ggaaacttgt tgtcaagatg      780

cctttccaag catcgcctgg gggtaagggt gagggaggtg gggctaccac atctgcccag      840

gtcatggtga tcaaacgccc tggcagaaag cgaaaagctg aagctgaccc ccaggccatt      900

cctaagaaac ggggtagaaa gcctgggagt gtggtggcag ctgctgcagc tgaggccaaa      960

aagaaagccg tgaaggagtc ttccatacgg tctgtgcatg agactgtgct ccccatcaag     1020

aagcgcaaga cccgggagac ggtcagcatc gaggtcaagg aagtggtgaa gcccctgctg     1080

gtgtccaccc ttggtgagaa aagcgggaag ggactgaaga cctgcaagag ccctgggcgt     1140

aaaagcaagg agagcagccc caaggggcgc agcagcagtg cctcctcccc acctaagaag     1200

gagcaccatc atcaccacca tcactcagag tccacaaagg cccccatgcc actgctccca     1260

tccccacccc cacctgagcc tgagagctct gaggacccca tcagcccccc tgagcctcag     1320

gacttgagca gcagcatctg caaagaagag aagatgcccc gaggaggctc actggaaagc     1380

gatggctgcc ccaaggagcc agctaagact cagcctatgg tcgccaccac taccacagtt     1440

gcagaaaagt acaaacaccg aggggaggga gagcgcaaag acattgtttc atcttccatg     1500

ccaaggccaa acagagagga gcctgtggac agccggacgc ccgtgaccga gagagttagc     1560

tga                                                                   1563


<210>  8
<211>  6087
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<223>  Plasmid for AVXS-201 production

<220>
<221>  misc_feature
<222>  (1)..(106)
<223>  mutated ITR

<220>
<221>  misc_feature
<222>  (151)..(699)
<223>  546 promotor fragment

<220>
<221>  misc_feature
<222>  (729)..(829)
<223>  SV40 intron

<220>
<221>  misc_feature
<222>  (848)..(2344)
<223>  hMECP2B

<220>
<221>  misc_feature
<222>  (2345)..(2393)
<223>  synthetic pA

<220>
<221>  misc_feature
<222>  (2418)..(2558)
<223>  ITR

<220>
<221>  misc_feature
<222>  (3309)..(4259)
<223>  kanamycin resistance

<220>
<221>  misc_feature
<222>  (4325)..(4939)
<223>  pMB1 ori

<400>  8
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggaatt cacgcgtgga      120

tctgaattca attcacgcgt ggtaccacgc gtgaacaacg ccaggctcct caacaggcaa      180

ctttgctact tctacagaaa atgataataa agaaatgctg gtgaagtcaa atgcttatca      240

caatggtgaa ctactcagca gggaggctct aataggcgcc aagagcctag acttccttaa      300

gcgccagagt ccacaagggc ccagttaatc ctcaacattc aaatgctgcc cacaaaacca      360

gcccctctgt gccctagccg cctctttttt ccaagtgaca gtagaactcc accaatccgc      420

agctgaatgg ggtccgcctc ttttccctgc ctaaacagac aggaactcct gccaattgag      480

ggcgtcaccg ctaaggctcc gccccagcct gggctccaca accaatgaag ggtaatctcg      540

acaaagagca aggggtgggg cgcgggcgcg caggtgcagc agcacacagg ctggtcggga      600

gggcggggcg cgacgtctgc cgtgcggggt cccggcatcg gttgcgcgcg cgctccctcc      660

tctcggagag agggctgtgg taaaacccgt ccggaaaacg cgtcgaaggg cgaattctgc      720

agataactgg taagtttagt cttttttgtc ttttatttca ggtcccggat ccggtggtgg      780

tgcaaatcaa agaactgctc ctcagtcgat gttgccttta cttctaggcc tgtacggaag      840

tgttactatg gccgccgccg ccgccgccgc gccgagcgga ggaggaggag gaggcgagga      900

ggagagactg gaagaaaagt cagaagacca ggacctccag ggcctcaagg acaaacccct      960

caagtttaaa aaggtgaaga aagataagaa agaagagaaa gagggcaagc atgagcccgt     1020

gcagccatca gcccaccact ctgctgagcc cgcagaggca ggcaaagcag agacatcaga     1080

agggtcaggc tccgccccgg ctgtgccgga agcttctgcc tcccccaaac agcggcgctc     1140

catcatccgt gaccggggac ccatgtatga tgaccccacc ctgcctgaag gctggacacg     1200

gaagcttaag caaaggaaat ctggccgctc tgctgggaag tatgatgtgt atttgatcaa     1260

tccccaggga aaagcctttc gctctaaagt ggagttgatt gcgtacttcg aaaaggtagg     1320

cgacacatcc ctggacccta atgattttga cttcacggta actgggagag ggagcccctc     1380

ccggcgagag cagaaaccac ctaagaagcc caaatctccc aaagctccag gaactggcag     1440

aggccgggga cgccccaaag ggagcggcac cacgagaccc aaggcggcca cgtcagaggg     1500

tgtgcaggtg aaaagggtcc tggagaaaag tcctgggaag ctccttgtca agatgccttt     1560

tcaaacttcg ccagggggca aggctgaggg gggtggggcc accacatcca cccaggtcat     1620

ggtgatcaaa cgccccggca ggaagcgaaa agctgaggcc gaccctcagg ccattcccaa     1680

gaaacggggc cgaaagccgg ggagtgtggt ggcagccgct gccgccgagg ccaaaaagaa     1740

agccgtgaag gagtcttcta tccgatctgt gcaggagacc gtactcccca tcaagaagcg     1800

caagacccgg gagacggtca gcatcgaggt caaggaagtg gtgaagcccc tgctggtgtc     1860

caccctcggt gagaagagcg ggaaaggact gaagacctgt aagagccctg ggcggaaaag     1920

caaggagagc agccccaagg ggcgcagcag cagcgcctcc tcacccccca agaaggagca     1980

ccaccaccat caccaccact cagagtcccc aaaggccccc gtgccactgc tcccacccct     2040

gcccccacct ccacctgagc ccgagagctc cgaggacccc accagccccc ctgagcccca     2100

ggacttgagc agcagcgtct gcaaagagga gaagatgccc agaggaggct cactggagag     2160

cgacggctgc cccaaggagc cagctaagac tcagcccgcg gttgccaccg ccgccacggc     2220

cgcagaaaag tacaaacacc gaggggaggg agagcgcaaa gacattgttt catcctccat     2280

gccaaggcca aacagagagg agcctgtgga cagccggacg cccgtgaccg agagagttag     2340

ctgaaataaa agatctttat tttcattaga tctgtgtgtt ggttttttgt gtggcatgct     2400

ggggagagat cgatctgagg aacccctagt gatggagttg gccactccct ctctgcgcgc     2460

tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc     2520

ggcctcagtg agcgagcgag cgcgcagaga gggagtggcc cccccccccc cccccccggc     2580

gattctcttg tttgctccag actctcaggc aatgacctga tagcctttgt agagacctct     2640

caaaaatagc taccctctcc ggcatgaatt tatcagctag aacggttgaa tatcatattg     2700

atggtgattt gactgtctcc ggcctttctc acccgtttga atctttacct acacattact     2760

caggcattgc atttaaaata tatgagggtt ctaaaaattt ttatccttgc gttgaaataa     2820

aggcttctcc cgcaaaagta ttacagggtc ataatgtttt tggtacaacc gatttagctt     2880

tatgctctga ggctttattg cttaattttg ctaattcttt gccttgcctg tatgatttat     2940

tggatgttgg aatcgcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca     3000

ccgcatatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagccccg     3060

acacccgcca acactatggt gcactctcag tacaatctgc tctgatgccg catagttaag     3120

ccagccccga cacccgccaa cacccgctga cgcgccctga cgggcttgtc tgctcccggc     3180

atccgcttac agacaagctg tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc     3240

gtcatcaccg aaacgcgcga gacgaaaggg cctcgtgata cgcctatttt tataggttaa     3300

tgtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt     3360

taaatcaatc taaagtatat atgagtaaac ttggtctgac agttagaaaa actcatcgag     3420

catcaaatga aactgcaatt tattcatatc aggattatca ataccatatt tttgaaaaag     3480

ccgtttctgt aatgaaggag aaaactcacc gaggcagttc cataggatgg caagatcctg     3540

gtatcggtct gcgattccga ctcgtccaac atcaatacaa cctattaatt tcccctcgtc     3600

aaaaataagg ttatcaagtg agaaatcacc atgagtgacg actgaatccg gtgagaatgg     3660

caaaagttta tgcatttctt tccagacttg ttcaacaggc cagccattac gctcgtcatc     3720

aaaatcactc gcatcaacca aaccgttatt cattcgtgat tgcgcctgag cgaggcgaaa     3780

tacgcgatcg ctgttaaaag gacaattaca aacaggaatc gagtgcaacc ggcgcaggaa     3840

cactgccagc gcatcaacaa tattttcacc tgaatcagga tattcttcta atacctggaa     3900

cgctgttttt ccggggatcg cagtggtgag taaccatgca tcatcaggag tacggataaa     3960

atgcttgatg gtcggaagtg gcataaattc cgtcagccag tttagtctga ccatctcatc     4020

tgtaacatca ttggcaacgc tacctttgcc atgtttcaga aacaactctg gcgcatcggg     4080

cttcccatac aagcgataga ttgtcgcacc tgattgcccg acattatcgc gagcccattt     4140

atacccatat aaatcagcat ccatgttgga atttaatcgc ggcctcgacg tttcccgttg     4200

aatatggctc atactcttcc tttttcaata ttattgaagc atttatcagg gttattgtct     4260

catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa     4320

gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa     4380

aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc     4440

gaaggtaact ggcttcagca gagcgcagat accaaatact gttcttctag tgtagccgta     4500

gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct     4560

gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg     4620

atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag     4680

cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc     4740

cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg     4800

agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt     4860

tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg     4920

gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca     4980

catgttcttt cctgcgttat cccctgattc tgtggataac cgtattaccg cctttgagtg     5040

agctgatacc gctcgccgca gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc     5100

ggaagagcgc ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatgcag     5160

ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc caacagttgc gcagcctgaa     5220

tggcgaatgg cgattccgtt gcaatggctg gcggtaatat tgttctggat attaccagca     5280

aggccgatag tttgagttct tctactcagg caagtgatgt tattactaat caaagaagta     5340

ttgcgacaac ggttaatttg cgtgatggac agactctttt actcggtggc ctcactgatt     5400

ataaaaacac ttctcaggat tctggcgtac cgttcctgtc taaaatccct ttaatcggcc     5460

tcctgtttag ctcccgctct gattctaacg aggaaagcac gttatacgtg ctcgtcaaag     5520

caaccatagt acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc     5580

agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc     5640

tttctcgcca cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg     5700

ttccgattta gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca     5760

cgtagtgggc catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc     5820

tttaatagtg gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct     5880

tttgatttat aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa     5940

caaaaattta acgcgaattt taacaaaata ttaacgctta caatttaaat atttgcttat     6000

acaatcttcc tgtttttggg gcttttctga ttatcaaccg gggtacatat gattgacatg     6060

ctagttttac gattaccgtt catcgcc                                         6087


