                         SEQUENCE LISTING

<110>  New York Blood Center, Inc.
 
<120>  Immunogenic Composition for MERS Coronavirus Infection

<130>  1958427-00262

<150>  US 61/424,309
<151>  2016-11-18

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  1353
<212>  PRT
<213>  MERS coronavirus

<400>  1

Met Ile His Ser Val Phe Leu Leu Met Phe Leu Leu Thr Pro Thr Glu 
1               5                   10                  15      


Ser Tyr Val Asp Val Gly Pro Asp Ser Val Lys Ser Ala Cys Ile Glu 
            20                  25                  30          


Val Asp Ile Gln Gln Thr Phe Phe Asp Lys Thr Trp Pro Arg Pro Ile 
        35                  40                  45              


Asp Val Ser Lys Ala Asp Gly Ile Ile Tyr Pro Gln Gly Arg Thr Tyr 
    50                  55                  60                  


Ser Asn Ile Thr Ile Thr Tyr Gln Gly Leu Phe Pro Tyr Gln Gly Asp 
65                  70                  75                  80  


His Gly Asp Met Tyr Val Tyr Ser Ala Gly His Ala Thr Gly Thr Thr 
                85                  90                  95      


Pro Gln Lys Leu Phe Val Ala Asn Tyr Ser Gln Asp Val Lys Gln Phe 
            100                 105                 110         


Ala Asn Gly Phe Val Val Arg Ile Gly Ala Ala Ala Asn Ser Thr Gly 
        115                 120                 125             


Thr Val Ile Ile Ser Pro Ser Thr Ser Ala Thr Ile Arg Lys Ile Tyr 
    130                 135                 140                 


Pro Ala Phe Met Leu Gly Ser Ser Val Gly Asn Phe Ser Asp Gly Lys 
145                 150                 155                 160 


Met Gly Arg Phe Phe Asn His Thr Leu Val Leu Leu Pro Asp Gly Cys 
                165                 170                 175     


Gly Thr Leu Leu Arg Ala Phe Tyr Cys Ile Leu Glu Pro Arg Ser Gly 
            180                 185                 190         


Asn His Cys Pro Ala Gly Asn Ser Tyr Thr Ser Phe Ala Thr Tyr His 
        195                 200                 205             


Thr Pro Ala Thr Asp Cys Ser Asp Gly Asn Tyr Asn Arg Asn Ala Ser 
    210                 215                 220                 


Leu Asn Ser Phe Lys Glu Tyr Phe Asn Leu Arg Asn Cys Thr Phe Met 
225                 230                 235                 240 


Tyr Thr Tyr Asn Ile Thr Glu Asp Glu Ile Leu Glu Trp Phe Gly Ile 
                245                 250                 255     


Thr Gln Thr Ala Gln Gly Val His Leu Phe Ser Ser Arg Tyr Val Asp 
            260                 265                 270         


Leu Tyr Gly Gly Asn Met Phe Gln Phe Ala Thr Leu Pro Val Tyr Asp 
        275                 280                 285             


Thr Ile Lys Tyr Tyr Ser Ile Ile Pro His Ser Ile Arg Ser Ile Gln 
    290                 295                 300                 


Ser Asp Arg Lys Ala Trp Ala Ala Phe Tyr Val Tyr Lys Leu Gln Pro 
305                 310                 315                 320 


Leu Thr Phe Leu Leu Asp Phe Ser Val Asp Gly Tyr Ile Arg Arg Ala 
                325                 330                 335     


Ile Asp Cys Gly Phe Asn Asp Leu Ser Gln Leu His Cys Ser Tyr Glu 
            340                 345                 350         


Ser Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser Phe Glu Ala 
        355                 360                 365             


Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp 
    370                 375                 380                 


Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys 
385                 390                 395                 400 


Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser 
                405                 410                 415     


Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala 
            420                 425                 430         


Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr 
        435                 440                 445             


Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile 
    450                 455                 460                 


Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile 
465                 470                 475                 480 


Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys 
                485                 490                 495     


Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp Arg Thr 
            500                 505                 510         


Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser 
        515                 520                 525             


Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln 
    530                 535                 540                 


Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr 
545                 550                 555                 560 


Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln 
                565                 570                 575     


Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn 
            580                 585                 590         


Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr Ser Leu 
        595                 600                 605             


Tyr Gly Val Ser Gly Arg Gly Val Phe Gln Asn Cys Thr Ala Val Gly 
    610                 615                 620                 


Val Arg Gln Gln Arg Phe Val Tyr Asp Ala Tyr Gln Asn Leu Val Gly 
625                 630                 635                 640 


Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr Cys Leu Arg Ala Cys Val Ser 
                645                 650                 655     


Val Pro Val Ser Val Ile Tyr Asp Lys Glu Thr Lys Thr His Ala Thr 
            660                 665                 670         


Leu Phe Gly Ser Val Ala Cys Glu His Ile Ser Ser Thr Met Ser Gln 
        675                 680                 685             


Tyr Ser Arg Ser Thr Arg Ser Met Leu Lys Arg Arg Asp Ser Thr Tyr 
    690                 695                 700                 


Gly Pro Leu Gln Thr Pro Val Gly Cys Val Leu Gly Leu Val Asn Ser 
705                 710                 715                 720 


Ser Leu Phe Val Glu Asp Cys Lys Leu Pro Leu Gly Gln Ser Leu Cys 
                725                 730                 735     


Ala Leu Pro Asp Thr Pro Ser Thr Leu Thr Pro Arg Ser Val Arg Ser 
            740                 745                 750         


Val Pro Gly Glu Met Arg Leu Ala Ser Ile Ala Phe Asn His Pro Ile 
        755                 760                 765             


Gln Val Asp Gln Leu Asn Ser Ser Tyr Phe Lys Leu Ser Ile Pro Thr 
    770                 775                 780                 


Asn Phe Ser Phe Gly Val Thr Gln Glu Tyr Ile Gln Thr Thr Ile Gln 
785                 790                 795                 800 


Lys Val Thr Val Asp Cys Lys Gln Tyr Val Cys Asn Gly Phe Gln Lys 
                805                 810                 815     


Cys Glu Gln Leu Leu Arg Glu Tyr Gly Gln Phe Cys Ser Lys Ile Asn 
            820                 825                 830         


Gln Ala Leu His Gly Ala Asn Leu Arg Gln Asp Asp Ser Val Arg Asn 
        835                 840                 845             


Leu Phe Ala Ser Val Lys Ser Ser Gln Ser Ser Pro Ile Ile Pro Gly 
    850                 855                 860                 


Phe Gly Gly Asp Phe Asn Leu Thr Leu Leu Glu Pro Val Ser Ile Ser 
865                 870                 875                 880 


Thr Gly Ser Arg Ser Ala Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp 
                885                 890                 895     


Lys Val Thr Ile Ala Asp Pro Gly Tyr Met Gln Gly Tyr Asp Asp Cys 
            900                 905                 910         


Met Gln Gln Gly Pro Ala Ser Ala Arg Asp Leu Ile Cys Ala Gln Tyr 
        915                 920                 925             


Val Ala Gly Tyr Lys Val Leu Pro Pro Leu Met Asp Val Asn Met Glu 
    930                 935                 940                 


Ala Ala Tyr Thr Ser Ser Leu Leu Gly Ser Ile Ala Gly Val Gly Trp 
945                 950                 955                 960 


Thr Ala Gly Leu Ser Ser Phe Ala Ala Ile Pro Phe Ala Gln Ser Ile 
                965                 970                 975     


Phe Tyr Arg Leu Asn Gly Val Gly Ile Thr Gln Gln Val Leu Ser Glu 
            980                 985                 990         


Asn Gln Lys Leu Ile Ala Asn Lys  Phe Asn Gln Ala Leu  Gly Ala Met 
        995                 1000                 1005             


Gln Thr  Gly Phe Thr Thr Thr  Asn Glu Ala Phe Gln  Lys Val Gln 
    1010                 1015                 1020             


Asp Ala  Val Asn Asn Asn Ala  Gln Ala Leu Ser Lys  Leu Ala Ser 
    1025                 1030                 1035             


Glu Leu  Ser Asn Thr Phe Gly  Ala Ile Ser Ala Ser  Ile Gly Asp 
    1040                 1045                 1050             


Ile Ile  Gln Arg Leu Asp Val  Leu Glu Gln Asp Ala  Gln Ile Asp 
    1055                 1060                 1065             


Arg Leu  Ile Asn Gly Arg Leu  Thr Thr Leu Asn Ala  Phe Val Ala 
    1070                 1075                 1080             


Gln Gln  Leu Val Arg Ser Glu  Ser Ala Ala Leu Ser  Ala Gln Leu 
    1085                 1090                 1095             


Ala Lys  Asp Lys Val Asn Glu  Cys Val Lys Ala Gln  Ser Lys Arg 
    1100                 1105                 1110             


Ser Gly  Phe Cys Gly Gln Gly  Thr His Ile Val Ser  Phe Val Val 
    1115                 1120                 1125             


Asn Ala  Pro Asn Gly Leu Tyr  Phe Met His Val Gly  Tyr Tyr Pro 
    1130                 1135                 1140             


Ser Asn  His Ile Glu Val Val  Ser Ala Tyr Gly Leu  Cys Asp Ala 
    1145                 1150                 1155             


Ala Asn  Pro Thr Asn Cys Ile  Ala Pro Val Asn Gly  Tyr Phe Ile 
    1160                 1165                 1170             


Lys Thr  Asn Asn Thr Arg Ile  Val Asp Glu Trp Ser  Tyr Thr Gly 
    1175                 1180                 1185             


Ser Ser  Phe Tyr Ala Pro Glu  Pro Ile Thr Ser Leu  Asn Thr Lys 
    1190                 1195                 1200             


Tyr Val  Ala Pro Gln Val Thr  Tyr Gln Asn Ile Ser  Thr Asn Leu 
    1205                 1210                 1215             


Pro Pro  Pro Leu Leu Gly Asn  Ser Thr Gly Ile Asp  Phe Gln Asp 
    1220                 1225                 1230             


Glu Leu  Asp Glu Phe Phe Lys  Asn Val Ser Thr Ser  Ile Pro Asn 
    1235                 1240                 1245             


Phe Gly  Ser Leu Thr Gln Ile  Asn Thr Thr Leu Leu  Asp Leu Thr 
    1250                 1255                 1260             


Tyr Glu  Met Leu Ser Leu Gln  Gln Val Val Lys Ala  Leu Asn Glu 
    1265                 1270                 1275             


Ser Tyr  Ile Asp Leu Lys Glu  Leu Gly Asn Tyr Thr  Tyr Tyr Asn 
    1280                 1285                 1290             


Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe Ile Ala  Gly Leu Val 
    1295                 1300                 1305             


Ala Leu  Ala Leu Cys Val Phe  Phe Ile Leu Cys Cys  Thr Gly Cys 
    1310                 1315                 1320             


Gly Thr  Asn Cys Met Gly Lys  Leu Lys Cys Asn Arg  Cys Cys Asp 
    1325                 1330                 1335             


Arg Tyr  Glu Glu Tyr Asp Leu  Glu Pro His Lys Val  His Val His 
    1340                 1345                 1350             


<210>  2
<211>  286
<212>  PRT
<213>  MERS coronavirus

<400>  2

Gln Ala Glu Gly Val Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr 
1               5                   10                  15      


Pro Pro Gln Val Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn 
            20                  25                  30          


Tyr Asn Leu Thr Lys Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr 
        35                  40                  45              


Cys Ser Gln Ile Ser Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser 
    50                  55                  60                  


Leu Ile Leu Asp Tyr Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu 
65                  70                  75                  80  


Ser Val Ser Ser Ala Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser 
                85                  90                  95      


Phe Ser Asn Pro Thr Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu 
            100                 105                 110         


Thr Thr Ile Thr Lys Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser 
        115                 120                 125             


Arg Leu Leu Ser Asp Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala 
    130                 135                 140                 


Asn Gln Tyr Ser Pro Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu 
145                 150                 155                 160 


Asp Gly Asp Tyr Tyr Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly 
                165                 170                 175     


Trp Leu Val Ala Ser Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln 
            180                 185                 190         


Met Gly Phe Gly Ile Thr Val Gln Tyr Gly Thr Asp Thr Asn Ser Val 
        195                 200                 205             


Cys Pro Lys Leu Glu Phe Ala Asn Asp Thr Lys Ile Ala Ser Gln Leu 
    210                 215                 220                 


Gly Asn Cys Val Glu Tyr Ser Leu Tyr Gly Val Ser Gly Arg Gly Val 
225                 230                 235                 240 


Phe Gln Asn Cys Thr Ala Val Gly Val Arg Gln Gln Arg Phe Val Tyr 
                245                 250                 255     


Asp Ala Tyr Gln Asn Leu Val Gly Tyr Tyr Ser Asp Asp Gly Asn Tyr 
            260                 265                 270         


Tyr Cys Leu Arg Ala Cys Val Ser Val Pro Val Ser Val Ile 
        275                 280                 285     


<210>  3
<211>  212
<212>  PRT
<213>  MERS coronavirus

<400>  3

Gln Ala Glu Gly Val Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr 
1               5                   10                  15      


Pro Pro Gln Val Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn 
            20                  25                  30          


Tyr Asn Leu Thr Lys Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr 
        35                  40                  45              


Cys Ser Gln Ile Ser Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser 
    50                  55                  60                  


Leu Ile Leu Asp Tyr Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu 
65                  70                  75                  80  


Ser Val Ser Ser Ala Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser 
                85                  90                  95      


Phe Ser Asn Pro Thr Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu 
            100                 105                 110         


Thr Thr Ile Thr Lys Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser 
        115                 120                 125             


Arg Leu Leu Ser Asp Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala 
    130                 135                 140                 


Asn Gln Tyr Ser Pro Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu 
145                 150                 155                 160 


Asp Gly Asp Tyr Tyr Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly 
                165                 170                 175     


Trp Leu Val Ala Ser Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln 
            180                 185                 190         


Met Gly Phe Gly Ile Thr Val Gln Tyr Gly Thr Asp Thr Asn Ser Val 
        195                 200                 205             


Cys Pro Lys Leu 
    210         


<210>  4
<211>  239
<212>  PRT
<213>  MERS coronavirus

<400>  4

Ser Tyr Glu Ser Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser 
1               5                   10                  15      


Phe Glu Ala Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val 
            20                  25                  30          


Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr 
        35                  40                  45              


Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys 
    50                  55                  60                  


Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser 
65                  70                  75                  80  


Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr 
                85                  90                  95      


Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala 
            100                 105                 110         


Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr 
        115                 120                 125             


Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys 
    130                 135                 140                 


Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp 
145                 150                 155                 160 


Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro 
                165                 170                 175     


Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr 
            180                 185                 190         


Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser 
        195                 200                 205             


Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile 
    210                 215                 220                 


Thr Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu 
225                 230                 235                 


<210>  5
<211>  231
<212>  PRT
<213>  MERS coronavirus

<400>  5

Ser Gly Val Tyr Ser Val Ser Ser Phe Glu Ala Lys Pro Ser Gly Ser 
1               5                   10                  15      


Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp Phe Ser Pro Leu Leu 
            20                  25                  30          


Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys Arg Leu Val Phe Thr 
        35                  40                  45              


Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser Leu Phe Ser Val Asn 
    50                  55                  60                  


Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala Ile Ala Ser Asn Cys 
65                  70                  75                  80  


Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr Pro Leu Ser Met Lys 
                85                  90                  95      


Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile Ser Gln Phe Asn Tyr 
            100                 105                 110         


Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile Leu Ala Thr Val Pro 
        115                 120                 125             


His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys Tyr Ser Tyr Ile Asn 
    130                 135                 140                 


Lys Cys Ser Arg Leu Leu Ser Asp Asp Arg Thr Glu Val Pro Gln Leu 
145                 150                 155                 160 


Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser Ile Val Pro Ser Thr 
                165                 170                 175     


Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln Leu Ser Pro Leu Glu 
            180                 185                 190         


Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr Val Ala Met Thr Glu 
        195                 200                 205             


Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln Tyr Gly Thr Asp Thr 
    210                 215                 220                 


Asn Ser Val Cys Pro Lys Leu 
225                 230     


<210>  6
<211>  222
<212>  PRT
<213>  MERS coronavirus

<400>  6

Glu Ala Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu 
1               5                   10                  15      


Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn 
            20                  25                  30          


Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu 
        35                  40                  45              


Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro 
    50                  55                  60                  


Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe 
65                  70                  75                  80  


Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly 
                85                  90                  95      


Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys 
            100                 105                 110         


Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro 
        115                 120                 125             


Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp 
    130                 135                 140                 


Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys 
145                 150                 155                 160 


Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg 
                165                 170                 175     


Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly 
            180                 185                 190         


Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr 
        195                 200                 205             


Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu 
    210                 215                 220         


<210>  7
<211>  240
<212>  PRT
<213>  MERS coronavirus

<400>  7

Glu Ala Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu 
1               5                   10                  15      


Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn 
            20                  25                  30          


Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu 
        35                  40                  45              


Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro 
    50                  55                  60                  


Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe 
65                  70                  75                  80  


Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly 
                85                  90                  95      


Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys 
            100                 105                 110         


Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro 
        115                 120                 125             


Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp 
    130                 135                 140                 


Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys 
145                 150                 155                 160 


Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg 
                165                 170                 175     


Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly 
            180                 185                 190         


Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr 
        195                 200                 205             


Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe 
    210                 215                 220                 


Ala Asn Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr 
225                 230                 235                 240 


<210>  8
<211>  468
<212>  PRT
<213>  artificial sequence

<220>
<223>  S350-588-Fc peptide

<400>  8

Ser Tyr Glu Ser Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser 
1               5                   10                  15      


Phe Glu Ala Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val 
            20                  25                  30          


Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr 
        35                  40                  45              


Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys 
    50                  55                  60                  


Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser 
65                  70                  75                  80  


Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr 
                85                  90                  95      


Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala 
            100                 105                 110         


Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr 
        115                 120                 125             


Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys 
    130                 135                 140                 


Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp 
145                 150                 155                 160 


Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro 
                165                 170                 175     


Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr 
            180                 185                 190         


Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser 
        195                 200                 205             


Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile 
    210                 215                 220                 


Thr Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Arg 
225                 230                 235                 240 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  9
<211>  460
<212>  PRT
<213>  artificial sequence

<220>
<223>  S358-588-Fc peptide

<400>  9

Ser Gly Val Tyr Ser Val Ser Ser Phe Glu Ala Lys Pro Ser Gly Ser 
1               5                   10                  15      


Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp Phe Ser Pro Leu Leu 
            20                  25                  30          


Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys Arg Leu Val Phe Thr 
        35                  40                  45              


Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser Leu Phe Ser Val Asn 
    50                  55                  60                  


Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala Ile Ala Ser Asn Cys 
65                  70                  75                  80  


Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr Pro Leu Ser Met Lys 
                85                  90                  95      


Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile Ser Gln Phe Asn Tyr 
            100                 105                 110         


Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile Leu Ala Thr Val Pro 
        115                 120                 125             


His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys Tyr Ser Tyr Ile Asn 
    130                 135                 140                 


Lys Cys Ser Arg Leu Leu Ser Asp Asp Arg Thr Glu Val Pro Gln Leu 
145                 150                 155                 160 


Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser Ile Val Pro Ser Thr 
                165                 170                 175     


Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln Leu Ser Pro Leu Glu 
            180                 185                 190         


Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr Val Ala Met Thr Glu 
        195                 200                 205             


Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln Tyr Gly Thr Asp Thr 
    210                 215                 220                 


Asn Ser Val Cys Pro Lys Leu Arg Ser Asp Lys Thr His Thr Cys Pro 
225                 230                 235                 240 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        275                 280                 285             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    290                 295                 300                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
305                 310                 315                 320 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                325                 330                 335     


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            340                 345                 350         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        355                 360                 365             


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    370                 375                 380                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
385                 390                 395                 400 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                405                 410                 415     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            420                 425                 430         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        435                 440                 445             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460 


<210>  10
<211>  451
<212>  PRT
<213>  artificial sequence

<220>
<223>  S367-588-Fc peptide

<400>  10

Glu Ala Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu 
1               5                   10                  15      


Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn 
            20                  25                  30          


Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu 
        35                  40                  45              


Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro 
    50                  55                  60                  


Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe 
65                  70                  75                  80  


Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly 
                85                  90                  95      


Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys 
            100                 105                 110         


Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro 
        115                 120                 125             


Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp 
    130                 135                 140                 


Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys 
145                 150                 155                 160 


Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg 
                165                 170                 175     


Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly 
            180                 185                 190         


Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr 
        195                 200                 205             


Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Arg Ser 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  11
<211>  469
<212>  PRT
<213>  artificial sequence

<220>
<223>  S367-606-Fc peptide

<400>  11

Glu Ala Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu 
1               5                   10                  15      


Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn 
            20                  25                  30          


Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu 
        35                  40                  45              


Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro 
    50                  55                  60                  


Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe 
65                  70                  75                  80  


Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly 
                85                  90                  95      


Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys 
            100                 105                 110         


Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro 
        115                 120                 125             


Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp 
    130                 135                 140                 


Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys 
145                 150                 155                 160 


Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg 
                165                 170                 175     


Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly 
            180                 185                 190         


Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr 
        195                 200                 205             


Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe 
    210                 215                 220                 


Ala Asn Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr 
225                 230                 235                 240 


Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys 
465                 


<210>  12
<211>  441
<212>  PRT
<213>  artificial sequence

<220>
<223>  S377-588-Fc peptide

<400>  12

Gln Ala Glu Gly Val Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr 
1               5                   10                  15      


Pro Pro Gln Val Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn 
            20                  25                  30          


Tyr Asn Leu Thr Lys Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr 
        35                  40                  45              


Cys Ser Gln Ile Ser Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser 
    50                  55                  60                  


Leu Ile Leu Asp Tyr Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu 
65                  70                  75                  80  


Ser Val Ser Ser Ala Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser 
                85                  90                  95      


Phe Ser Asn Pro Thr Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu 
            100                 105                 110         


Thr Thr Ile Thr Lys Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser 
        115                 120                 125             


Arg Leu Leu Ser Asp Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala 
    130                 135                 140                 


Asn Gln Tyr Ser Pro Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu 
145                 150                 155                 160 


Asp Gly Asp Tyr Tyr Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly 
                165                 170                 175     


Trp Leu Val Ala Ser Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln 
            180                 185                 190         


Met Gly Phe Gly Ile Thr Val Gln Tyr Gly Thr Asp Thr Asn Ser Val 
        195                 200                 205             


Cys Pro Lys Leu Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


<210>  13
<211>  515
<212>  PRT
<213>  artificial sequence

<220>
<223>  S377-662-Fc peptide

<400>  13

Gln Ala Glu Gly Val Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr 
1               5                   10                  15      


Pro Pro Gln Val Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn 
            20                  25                  30          


Tyr Asn Leu Thr Lys Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr 
        35                  40                  45              


Cys Ser Gln Ile Ser Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser 
    50                  55                  60                  


Leu Ile Leu Asp Tyr Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu 
65                  70                  75                  80  


Ser Val Ser Ser Ala Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser 
                85                  90                  95      


Phe Ser Asn Pro Thr Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu 
            100                 105                 110         


Thr Thr Ile Thr Lys Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser 
        115                 120                 125             


Arg Leu Leu Ser Asp Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala 
    130                 135                 140                 


Asn Gln Tyr Ser Pro Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu 
145                 150                 155                 160 


Asp Gly Asp Tyr Tyr Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly 
                165                 170                 175     


Trp Leu Val Ala Ser Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln 
            180                 185                 190         


Met Gly Phe Gly Ile Thr Val Gln Tyr Gly Thr Asp Thr Asn Ser Val 
        195                 200                 205             


Cys Pro Lys Leu Glu Phe Ala Asn Asp Thr Lys Ile Ala Ser Gln Leu 
    210                 215                 220                 


Gly Asn Cys Val Glu Tyr Ser Leu Tyr Gly Val Ser Gly Arg Gly Val 
225                 230                 235                 240 


Phe Gln Asn Cys Thr Ala Val Gly Val Arg Gln Gln Arg Phe Val Tyr 
                245                 250                 255     


Asp Ala Tyr Gln Asn Leu Val Gly Tyr Tyr Ser Asp Asp Gly Asn Tyr 
            260                 265                 270         


Tyr Cys Leu Arg Ala Cys Val Ser Val Pro Val Ser Val Ile Arg Ser 
        275                 280                 285             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    290                 295                 300                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
305                 310                 315                 320 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                325                 330                 335     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            340                 345                 350         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        355                 360                 365             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    370                 375                 380                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
385                 390                 395                 400 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                405                 410                 415     


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
            420                 425                 430         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        435                 440                 445             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    450                 455                 460                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
465                 470                 475                 480 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                485                 490                 495     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            500                 505                 510         


Pro Gly Lys 
        515 


<210>  14
<211>  27
<212>  PRT
<213>  Bacteriophage T4

<400>  14

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


<210>  15
<211>  229
<212>  PRT
<213>  homo sapiens

<400>  15

Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly Lys 
225                 


<210>  16
<211>  234
<212>  PRT
<213>  mus musculus

<400>  16

Arg Ser Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
1               5                   10                  15      


Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
            20                  25                  30          


Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
        35                  40                  45              


Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
    50                  55                  60                  


Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
65                  70                  75                  80  


Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
                85                  90                  95      


His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
            100                 105                 110         


Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
        115                 120                 125             


Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
    130                 135                 140                 


Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
145                 150                 155                 160 


Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
                165                 170                 175     


Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
            180                 185                 190         


Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
        195                 200                 205             


Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
    210                 215                 220                 


Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
225                 230                 


<210>  17
<211>  225
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  17

Arg Ser Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro 
1               5                   10                  15      


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            20                  25                  30          


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Asp Asp 
        35                  40                  45              


Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val Arg Thr 
    50                  55                  60                  


Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile Arg Val 
65                  70                  75                  80  


Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly Lys Glu 
                85                  90                  95      


Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            100                 105                 110         


Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val Tyr Thr 
        115                 120                 125             


Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser Leu Thr 
    130                 135                 140                 


Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu 
145                 150                 155                 160 


Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala Val Leu 
                165                 170                 175     


Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Pro Thr 
            180                 185                 190         


Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met His Glu 
        195                 200                 205             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser Pro Gly 
    210                 215                 220                 


Lys 
225 


<210>  18
<211>  302
<212>  PRT
<213>  homo sapiens

<400>  18

His Leu Ile Val Thr Pro Ser Gly Cys Gly Glu Gln Asn Met Ile Gly 
1               5                   10                  15      


Met Thr Pro Thr Val Ile Ala Val His Tyr Leu Asp Glu Thr Glu Gln 
            20                  25                  30          


Trp Glu Lys Phe Gly Leu Glu Lys Arg Gln Gly Ala Leu Glu Leu Ile 
        35                  40                  45              


Lys Lys Gly Tyr Thr Gln Gln Leu Ala Phe Arg Gln Pro Ser Ser Ala 
    50                  55                  60                  


Phe Ala Ala Phe Val Lys Arg Ala Pro Ser Thr Trp Leu Thr Ala Tyr 
65                  70                  75                  80  


Val Val Lys Val Phe Ser Leu Ala Val Asn Leu Ile Ala Ile Asp Ser 
                85                  90                  95      


Gln Val Leu Cys Gly Ala Val Lys Trp Leu Ile Leu Glu Lys Gln Lys 
            100                 105                 110         


Pro Asp Gly Val Phe Gln Glu Asp Ala Pro Val Ile His Gln Glu Met 
        115                 120                 125             


Ile Gly Gly Leu Arg Asn Asn Asn Glu Lys Asp Met Ala Leu Thr Ala 
    130                 135                 140                 


Phe Val Leu Ile Ser Leu Gln Glu Ala Lys Asp Ile Cys Glu Glu Gln 
145                 150                 155                 160 


Val Asn Ser Leu Pro Gly Ser Ile Thr Lys Ala Gly Asp Phe Leu Glu 
                165                 170                 175     


Ala Asn Tyr Met Asn Leu Gln Arg Ser Tyr Thr Val Ala Ile Ala Gly 
            180                 185                 190         


Tyr Ala Leu Ala Gln Met Gly Arg Leu Lys Gly Pro Leu Leu Asn Lys 
        195                 200                 205             


Phe Leu Thr Thr Ala Lys Asp Lys Asn Arg Trp Glu Asp Pro Gly Lys 
    210                 215                 220                 


Gln Leu Tyr Asn Val Glu Ala Thr Ser Tyr Ala Leu Leu Ala Leu Leu 
225                 230                 235                 240 


Gln Leu Lys Asp Phe Asp Phe Val Pro Pro Val Val Arg Trp Leu Asn 
                245                 250                 255     


Glu Gln Arg Tyr Tyr Gly Gly Gly Tyr Gly Ser Thr Gln Ala Thr Phe 
            260                 265                 270         


Met Val Phe Gln Ala Leu Ala Gln Tyr Gln Lys Asp Ala Pro Asp His 
        275                 280                 285             


Gln Glu Leu Asn Leu Asp Val Ser Leu Gln Leu Pro Ser Arg 
    290                 295                 300         


<210>  19
<211>  104
<212>  PRT
<213>  vibrio cholerae

<400>  19

Met Thr Pro Gln Asn Ile Thr Asp Leu Cys Ala Glu Tyr His Asn Thr 
1               5                   10                  15      


Gln Ile His Thr Leu Asn Asp Lys Ile Phe Ser Tyr Thr Glu Ser Leu 
            20                  25                  30          


Ala Gly Lys Arg Glu Met Ala Ile Ile Thr Phe Lys Asn Gly Ala Thr 
        35                  40                  45              


Phe Gln Val Glu Val Pro Gly Ser Gln His Ile Asp Ser Gln Lys Lys 
    50                  55                  60                  


Ala Ile Glu Arg Met Lys Asp Thr Leu Arg Ile Ala Tyr Leu Thr Glu 
65                  70                  75                  80  


Ala Lys Val Glu Lys Leu Cys Val Trp Asn Asn Lys Thr Pro Arg Ala 
                85                  90                  95      


Ile Ala Ala Ile Ser Met Ala Asn 
            100                 


<210>  20
<211>  29
<212>  PRT
<213>  Bacteriophage T4

<400>  20

Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val 
1               5                   10                  15      


Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25                  


<210>  21
<211>  32
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  21

Met Lys Gln Ile Glu Asp Lys Ile Glu Glu Ile Leu Ser Lys Ile Tyr 
1               5                   10                  15      


His Ile Glu Asn Glu Ile Ala Arg Ile Lys Lys Leu Ile Gly Glu Val 
            20                  25                  30          


<210>  22
<211>  28
<212>  PRT
<213>  artificial sequence

<220>
<223>  IQ trimerization sequence

<400>  22

Arg Met Lys Gln Ile Glu Asp Lys Ile Glu Glu Ile Glu Ser Lys Gln 
1               5                   10                  15      


Lys Lys Ile Glu Asn Glu Ile Ala Arg Ile Lys Lys 
            20                  25              


<210>  23
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  IZ trimerization sequence

<400>  23

Ile Lys Lys Glu Ile Glu Ala Ile Lys Lys Glu Gln Glu Ala Ile Lys 
1               5                   10                  15      


Lys Lys Ile Glu Ala Ile Glu Lys 
            20                  


<210>  24
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker sequence

<400>  24

Gly Gly Gly Gly Ser 
1               5   


<210>  25
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  aa377-588 of MERS-CoV S protein with T579N mutation

<400>  25

Gln Ala Glu Gly Val Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr 
1               5                   10                  15      


Pro Pro Gln Val Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn 
            20                  25                  30          


Tyr Asn Leu Thr Lys Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr 
        35                  40                  45              


Cys Ser Gln Ile Ser Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser 
    50                  55                  60                  


Leu Ile Leu Asp Tyr Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu 
65                  70                  75                  80  


Ser Val Ser Ser Ala Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser 
                85                  90                  95      


Phe Ser Asn Pro Thr Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu 
            100                 105                 110         


Thr Thr Ile Thr Lys Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser 
        115                 120                 125             


Arg Leu Leu Ser Asp Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala 
    130                 135                 140                 


Asn Gln Tyr Ser Pro Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu 
145                 150                 155                 160 


Asp Gly Asp Tyr Tyr Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly 
                165                 170                 175     


Trp Leu Val Ala Ser Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln 
            180                 185                 190         


Met Gly Phe Gly Ile Thr Val Gln Tyr Gly Asn Asp Thr Asn Ser Val 
        195                 200                 205             


Cys Pro Lys Leu 
    210         


<210>  26
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S377-588-Fc with T579N mutation

<400>  26

Gln Ala Glu Gly Val Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr 
1               5                   10                  15      


Pro Pro Gln Val Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn 
            20                  25                  30          


Tyr Asn Leu Thr Lys Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr 
        35                  40                  45              


Cys Ser Gln Ile Ser Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser 
    50                  55                  60                  


Leu Ile Leu Asp Tyr Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu 
65                  70                  75                  80  


Ser Val Ser Ser Ala Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser 
                85                  90                  95      


Phe Ser Asn Pro Thr Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu 
            100                 105                 110         


Thr Thr Ile Thr Lys Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser 
        115                 120                 125             


Arg Leu Leu Ser Asp Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala 
    130                 135                 140                 


Asn Gln Tyr Ser Pro Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu 
145                 150                 155                 160 


Asp Gly Asp Tyr Tyr Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly 
                165                 170                 175     


Trp Leu Val Ala Ser Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln 
            180                 185                 190         


Met Gly Phe Gly Ile Thr Val Gln Tyr Gly Asn Asp Thr Asn Ser Val 
        195                 200                 205             


Cys Pro Lys Leu Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440     


