                               SEQUENCE LISTING

<110> CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> THERAPEUTIC MODULATION OF C-FOS IN THE EYE

<130> 048218-549001WO

<140> PCT/US2017/062313
<141> 2017-11-17

<150> 62/423,464
<151> 2016-11-17

<160> 54    

<170> PatentIn version 3.5

<210> 1
<211> 2158
<212> DNA
<213> Homo sapiens

<400> 1
attcataaaa cgcttgttat aaaagcagtg gctgcggcgc ctcgtactcc aaccgcatct       60

gcagcgagca tctgagaagc caagactgag ccggcggccg cggcgcagcg aacgagcagt      120

gaccgtgctc ctacccagct ctgctccaca gcgcccacct gtctccgccc ctcggcccct      180

cgcccggctt tgcctaaccg ccacgatgat gttctcgggc ttcaacgcag actacgaggc      240

gtcatcctcc cgctgcagca gcgcgtcccc ggccggggat agcctctctt actaccactc      300

acccgcagac tccttctcca gcatgggctc gcctgtcaac gcgcaggact tctgcacgga      360

cctggccgtc tccagtgcca acttcattcc cacggtcact gccatctcga ccagtccgga      420

cctgcagtgg ctggtgcagc ccgccctcgt ctcctccgtg gccccatcgc agaccagagc      480

ccctcaccct ttcggagtcc ccgccccctc cgctggggct tactccaggg ctggcgttgt      540

gaagaccatg acaggaggcc gagcgcagag cattggcagg aggggcaagg tggaacagtt      600

atctccagaa gaagaagaga aaaggagaat ccgaagggaa aggaataaga tggctgcagc      660

caaatgccgc aaccggagga gggagctgac tgatacactc caagcggaga cagaccaact      720

agaagatgag aagtctgctt tgcagaccga gattgccaac ctgctgaagg agaaggaaaa      780

actagagttc atcctggcag ctcaccgacc tgcctgcaag atccctgatg acctgggctt      840

cccagaagag atgtctgtgg cttcccttga tctgactggg ggcctgccag aggttgccac      900

cccggagtct gaggaggcct tcaccctgcc tctcctcaat gaccctgagc ccaagccctc      960

agtggaacct gtcaagagca tcagcagcat ggagctgaag accgagccct ttgatgactt     1020

cctgttccca gcatcatcca ggcccagtgg ctctgagaca gcccgctccg tgccagacat     1080

ggacctatct gggtccttct atgcagcaga ctgggagcct ctgcacagtg gctccctggg     1140

gatggggccc atggccacag agctggagcc cctgtgcact ccggtggtca cctgtactcc     1200

cagctgcact gcttacacgt cttccttcgt cttcacctac cccgaggctg actccttccc     1260

cagctgtgca gctgcccacc gcaagggcag cagcagcaat gagccttcct ctgactcgct     1320

cagctcaccc acgctgctgg ccctgtgagg gggcagggaa ggggaggcag ccggcaccca     1380

caagtgccac tgcccgagct ggtgcattac agagaggaga aacacatctt ccctagaggg     1440

ttcctgtaga cctagggagg accttatctg tgcgtgaaac acaccaggct gtgggcctca     1500

aggacttgaa agcatccatg tgtggactca agtccttacc tcttccggag atgtagcaaa     1560

acgcatggag tgtgtattgt tcccagtgac acttcagaga gctggtagtt agtagcatgt     1620

tgagccaggc ctgggtctgt gtctcttttc tctttctcct tagtcttctc atagcattaa     1680

ctaatctatt gggttcatta ttggaattaa cctggtgctg gatattttca aattgtatct     1740

agtgcagctg attttaacaa taactactgt gttcctggca atagtgtgtt ctgattagaa     1800

atgaccaata ttatactaag aaaagatacg actttatttt ctggtagata gaaataaata     1860

gctatatcca tgtactgtag tttttcttca acatcaatgt tcattgtaat gttactgatc     1920

atgcattgtt gaggtggtct gaatgttctg acattaacag ttttccatga aaacgtttta     1980

ttgtgttttt aatttattta ttaagatgga ttctcagata tttatatttt tattttattt     2040

ttttctacct tgaggtcttt tgacatgtgg aaagtgaatt tgaatgaaaa atttaagcat     2100

tgtttgctta ttgttccaag acattgtcaa taaaagcatt taagttgaat gcgaccaa       2158


<210> 2
<211> 2158
<212> RNA
<213> Homo sapiens

<400> 2
auucauaaaa cgcuuguuau aaaagcagug gcugcggcgc cucguacucc aaccgcaucu       60

gcagcgagca ucugagaagc caagacugag ccggcggccg cggcgcagcg aacgagcagu      120

gaccgugcuc cuacccagcu cugcuccaca gcgcccaccu gucuccgccc cucggccccu      180

cgcccggcuu ugccuaaccg ccacgaugau guucucgggc uucaacgcag acuacgaggc      240

gucauccucc cgcugcagca gcgcgucccc ggccggggau agccucucuu acuaccacuc      300

acccgcagac uccuucucca gcaugggcuc gccugucaac gcgcaggacu ucugcacgga      360

ccuggccguc uccagugcca acuucauucc cacggucacu gccaucucga ccaguccgga      420

ccugcagugg cuggugcagc ccgcccucgu cuccuccgug gccccaucgc agaccagagc      480

cccucacccu uucggagucc ccgcccccuc cgcuggggcu uacuccaggg cuggcguugu      540

gaagaccaug acaggaggcc gagcgcagag cauuggcagg aggggcaagg uggaacaguu      600

aucuccagaa gaagaagaga aaaggagaau ccgaagggaa aggaauaaga uggcugcagc      660

caaaugccgc aaccggagga gggagcugac ugauacacuc caagcggaga cagaccaacu      720

agaagaugag aagucugcuu ugcagaccga gauugccaac cugcugaagg agaaggaaaa      780

acuagaguuc auccuggcag cucaccgacc ugccugcaag aucccugaug accugggcuu      840

cccagaagag augucugugg cuucccuuga ucugacuggg ggccugccag agguugccac      900

cccggagucu gaggaggccu ucacccugcc ucuccucaau gacccugagc ccaagcccuc      960

aguggaaccu gucaagagca ucagcagcau ggagcugaag accgagcccu uugaugacuu     1020

ccuguuccca gcaucaucca ggcccagugg cucugagaca gcccgcuccg ugccagacau     1080

ggaccuaucu ggguccuucu augcagcaga cugggagccu cugcacagug gcucccuggg     1140

gauggggccc auggccacag agcuggagcc ccugugcacu ccggugguca ccuguacucc     1200

cagcugcacu gcuuacacgu cuuccuucgu cuucaccuac cccgaggcug acuccuuccc     1260

cagcugugca gcugcccacc gcaagggcag cagcagcaau gagccuuccu cugacucgcu     1320

cagcucaccc acgcugcugg cccugugagg gggcagggaa ggggaggcag ccggcaccca     1380

caagugccac ugcccgagcu ggugcauuac agagaggaga aacacaucuu cccuagaggg     1440

uuccuguaga ccuagggagg accuuaucug ugcgugaaac acaccaggcu gugggccuca     1500

aggacuugaa agcauccaug uguggacuca aguccuuacc ucuuccggag auguagcaaa     1560

acgcauggag uguguauugu ucccagugac acuucagaga gcugguaguu aguagcaugu     1620

ugagccaggc cugggucugu gucucuuuuc ucuuucuccu uagucuucuc auagcauuaa     1680

cuaaucuauu ggguucauua uuggaauuaa ccuggugcug gauauuuuca aauuguaucu     1740

agugcagcug auuuuaacaa uaacuacugu guuccuggca auaguguguu cugauuagaa     1800

augaccaaua uuauacuaag aaaagauacg acuuuauuuu cugguagaua gaaauaaaua     1860

gcuauaucca uguacuguag uuuuucuuca acaucaaugu ucauuguaau guuacugauc     1920

augcauuguu gagguggucu gaauguucug acauuaacag uuuuccauga aaacguuuua     1980

uuguguuuuu aauuuauuua uuaagaugga uucucagaua uuuauauuuu uauuuuauuu     2040

uuuucuaccu ugaggucuuu ugacaugugg aaagugaauu ugaaugaaaa auuuaagcau     2100

uguuugcuua uuguuccaag acauugucaa uaaaagcauu uaaguugaau gcgaccaa       2158


<210> 3
<211> 380
<212> PRT
<213> Homo sapiens

<400> 3
Met Met Phe Ser Gly Phe Asn Ala Asp Tyr Glu Ala Ser Ser Ser Arg 
1               5                   10                  15      


Cys Ser Ser Ala Ser Pro Ala Gly Asp Ser Leu Ser Tyr Tyr His Ser 
            20                  25                  30          


Pro Ala Asp Ser Phe Ser Ser Met Gly Ser Pro Val Asn Ala Gln Asp 
        35                  40                  45              


Phe Cys Thr Asp Leu Ala Val Ser Ser Ala Asn Phe Ile Pro Thr Val 
    50                  55                  60                  


Thr Ala Ile Ser Thr Ser Pro Asp Leu Gln Trp Leu Val Gln Pro Ala 
65                  70                  75                  80  


Leu Val Ser Ser Val Ala Pro Ser Gln Thr Arg Ala Pro His Pro Phe 
                85                  90                  95      


Gly Val Pro Ala Pro Ser Ala Gly Ala Tyr Ser Arg Ala Gly Val Val 
            100                 105                 110         


Lys Thr Met Thr Gly Gly Arg Ala Gln Ser Ile Gly Arg Arg Gly Lys 
        115                 120                 125             


Val Glu Gln Leu Ser Pro Glu Glu Glu Glu Lys Arg Arg Ile Arg Arg 
    130                 135                 140                 


Glu Arg Asn Lys Met Ala Ala Ala Lys Cys Arg Asn Arg Arg Arg Glu 
145                 150                 155                 160 


Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp Glu Lys 
                165                 170                 175     


Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys Glu Lys 
            180                 185                 190         


Leu Glu Phe Ile Leu Ala Ala His Arg Pro Ala Cys Lys Ile Pro Asp 
        195                 200                 205             


Asp Leu Gly Phe Pro Glu Glu Met Ser Val Ala Ser Leu Asp Leu Thr 
    210                 215                 220                 


Gly Gly Leu Pro Glu Val Ala Thr Pro Glu Ser Glu Glu Ala Phe Thr 
225                 230                 235                 240 


Leu Pro Leu Leu Asn Asp Pro Glu Pro Lys Pro Ser Val Glu Pro Val 
                245                 250                 255     


Lys Ser Ile Ser Ser Met Glu Leu Lys Thr Glu Pro Phe Asp Asp Phe 
            260                 265                 270         


Leu Phe Pro Ala Ser Ser Arg Pro Ser Gly Ser Glu Thr Ala Arg Ser 
        275                 280                 285             


Val Pro Asp Met Asp Leu Ser Gly Ser Phe Tyr Ala Ala Asp Trp Glu 
    290                 295                 300                 


Pro Leu His Ser Gly Ser Leu Gly Met Gly Pro Met Ala Thr Glu Leu 
305                 310                 315                 320 


Glu Pro Leu Cys Thr Pro Val Val Thr Cys Thr Pro Ser Cys Thr Ala 
                325                 330                 335     


Tyr Thr Ser Ser Phe Val Phe Thr Tyr Pro Glu Ala Asp Ser Phe Pro 
            340                 345                 350         


Ser Cys Ala Ala Ala His Arg Lys Gly Ser Ser Ser Asn Glu Pro Ser 
        355                 360                 365             


Ser Asp Ser Leu Ser Ser Pro Thr Leu Leu Ala Leu 
    370                 375                 380 


<210> 4
<211> 208
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (48)..(147)
<223> a, c, t, g, unknown or other

<400> 4
ccctcgcccg gctttgccta accgccacga tgatgttctc gggcttcnnn nnnnnnnnnn       60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnnntat tgttccaaga cattgtcaat aaaagcattt      180

aagttgaatg cgaccaacct tgtgctct                                         208


<210> 5
<211> 2107
<212> DNA
<213> Mus musculus

<400> 5
cagcgagcaa ctgagaagac tggatagagc cggcggttcc gcgaacgagc agtgaccgcg       60

ctcccaccca gctctgctct gcagctccca ccagtgtcta cccctggacc ccttgccggg      120

ctttccccaa acttcgacca tgatgttctc gggtttcaac gccgactacg aggcgtcatc      180

ctcccgctgc agtagcgcct ccccggccgg ggacagcctt tcctactacc attccccagc      240

cgactccttc tccagcatgg gctctcctgt caacacacag gacttttgcg cagatctgtc      300

cgtctctagt gccaacttta tccccacggt gacagccatc tccaccagcc cagacctgca      360

gtggctggtg cagcccactc tggtctcctc cgtggcccca tcgcagacca gagcgcccca      420

tccttacgga ctccccaccc agtctgctgg ggcttacgcc agagcgggaa tggtgaagac      480

cgtgtcagga ggcagagcgc agagcatcgg cagaaggggc aaagtagagc agctatctcc      540

tgaagaggaa gagaaacgga gaatccgaag ggaacggaat aagatggctg cagccaagtg      600

ccggaatcgg aggagggagc tgacagatac actccaagcg gagacagatc aacttgaaga      660

tgagaagtct gcgttgcaga ctgagattgc caatctgctg aaagagaagg aaaaactgga      720

gtttattttg gcagcccacc gacctgcctg caagatcccc gatgaccttg gcttcccaga      780

ggagatgtct gtggcctccc tggatttgac tggaggtctg cctgaggctt ccaccccaga      840

gtctgaggag gccttcaccc tgccccttct caacgaccct gagcccaagc catccttgga      900

gccagtcaag agcatcagca acgtggagct gaaggcagaa ccctttgatg acttcttgtt      960

tccggcatca tctaggccca gtggctcaga gacctcccgc tctgtgccag atgtggacct     1020

gtccggttcc ttctatgcag cagactggga gcctctgcac agcaattcct tggggatggg     1080

gcccatggtc acagagctgg agcccctgtg tactcccgtg gtcacctgta ctccgggctg     1140

cactacttac acgtcttcct ttgtcttcac ctaccctgaa gctgactcct tcccaagctg     1200

tgccgctgcc caccgaaagg gcagcagcag caacgagccc tcctccgact ccctgagctc     1260

acccacgctg ctggccctgt gagcagtcag agaaggcaag gcagccggca tccagacgtg     1320

ccactgcccg agctggtgca ttacagagag gagaaacacg tcttccctcg aaggttcccg     1380

tcgacctagg gaggacctta cctgttcgtg aaacacacca ggctgtgggc ctcaaggact     1440

tgcaagcatc cacatctggc ctccagtcct cacctcttcc agagatgtag caaaaacaaa     1500

acaaaacaaa acaaaaaacc gcatggagtg tgttgttcct agtgacacct gagagctggt     1560

agttagtaga gcatgtgagt caaggcctgg tctgtgtctc ttttctcttt ctccttagtt     1620

ttctcatagc actaactaat ctgttgggtt cattattgga attaacctgg tgctggattg     1680

tatctagtgc agctgatttt aacaatacct actgtgttcc tggcaatagc gtgttccaat     1740

tagaaacgac caatattaaa ctaagaaaag ataggacttt attttccagt agatagaaat     1800

caatagctat atccatgtac tgtagtcctt cagcgtcaat gttcattgtc atgttactga     1860

tcatgcattg tcgaggtggt ctgaatgttc tgacattaac agttttccat gaaaacgttt     1920

ttattgtgtt ttcaatttat ttattaagat ggattctcag atatttatat ttttatttta     1980

tttttttcta ccctgaggtc tttcgacatg tggaaagtga atttgaatga aaaattttaa     2040

gcattgtttg cttattgttc caagacattg tcaataaaag catttaagtt gaaaaaaaaa     2100

aaaaaaa                                                               2107


<210> 6
<211> 2107
<212> RNA
<213> Mus musculus

<400> 6
cagcgagcaa cugagaagac uggauagagc cggcgguucc gcgaacgagc agugaccgcg       60

cucccaccca gcucugcucu gcagcuccca ccagugucua ccccuggacc ccuugccggg      120

cuuuccccaa acuucgacca ugauguucuc ggguuucaac gccgacuacg aggcgucauc      180

cucccgcugc aguagcgccu ccccggccgg ggacagccuu uccuacuacc auuccccagc      240

cgacuccuuc uccagcaugg gcucuccugu caacacacag gacuuuugcg cagaucuguc      300

cgucucuagu gccaacuuua uccccacggu gacagccauc uccaccagcc cagaccugca      360

guggcuggug cagcccacuc uggucuccuc cguggcccca ucgcagacca gagcgcccca      420

uccuuacgga cuccccaccc agucugcugg ggcuuacgcc agagcgggaa uggugaagac      480

cgugucagga ggcagagcgc agagcaucgg cagaaggggc aaaguagagc agcuaucucc      540

ugaagaggaa gagaaacgga gaauccgaag ggaacggaau aagauggcug cagccaagug      600

ccggaaucgg aggagggagc ugacagauac acuccaagcg gagacagauc aacuugaaga      660

ugagaagucu gcguugcaga cugagauugc caaucugcug aaagagaagg aaaaacugga      720

guuuauuuug gcagcccacc gaccugccug caagaucccc gaugaccuug gcuucccaga      780

ggagaugucu guggccuccc uggauuugac uggaggucug ccugaggcuu ccaccccaga      840

gucugaggag gccuucaccc ugccccuucu caacgacccu gagcccaagc cauccuugga      900

gccagucaag agcaucagca acguggagcu gaaggcagaa cccuuugaug acuucuuguu      960

uccggcauca ucuaggccca guggcucaga gaccucccgc ucugugccag auguggaccu     1020

guccgguucc uucuaugcag cagacuggga gccucugcac agcaauuccu uggggauggg     1080

gcccaugguc acagagcugg agccccugug uacucccgug gucaccugua cuccgggcug     1140

cacuacuuac acgucuuccu uugucuucac cuacccugaa gcugacuccu ucccaagcug     1200

ugccgcugcc caccgaaagg gcagcagcag caacgagccc uccuccgacu cccugagcuc     1260

acccacgcug cuggcccugu gagcagucag agaaggcaag gcagccggca uccagacgug     1320

ccacugcccg agcuggugca uuacagagag gagaaacacg ucuucccucg aagguucccg     1380

ucgaccuagg gaggaccuua ccuguucgug aaacacacca ggcugugggc cucaaggacu     1440

ugcaagcauc cacaucuggc cuccaguccu caccucuucc agagauguag caaaaacaaa     1500

acaaaacaaa acaaaaaacc gcauggagug uguuguuccu agugacaccu gagagcuggu     1560

aguuaguaga gcaugugagu caaggccugg ucugugucuc uuuucucuuu cuccuuaguu     1620

uucucauagc acuaacuaau cuguuggguu cauuauugga auuaaccugg ugcuggauug     1680

uaucuagugc agcugauuuu aacaauaccu acuguguucc uggcaauagc guguuccaau     1740

uagaaacgac caauauuaaa cuaagaaaag auaggacuuu auuuuccagu agauagaaau     1800

caauagcuau auccauguac uguaguccuu cagcgucaau guucauuguc auguuacuga     1860

ucaugcauug ucgagguggu cugaauguuc ugacauuaac aguuuuccau gaaaacguuu     1920

uuauuguguu uucaauuuau uuauuaagau ggauucucag auauuuauau uuuuauuuua     1980

uuuuuuucua cccugagguc uuucgacaug uggaaaguga auuugaauga aaaauuuuaa     2040

gcauuguuug cuuauuguuc caagacauug ucaauaaaag cauuuaaguu gaaaaaaaaa     2100

aaaaaaa                                                               2107


<210> 7
<211> 380
<212> PRT
<213> Mus musculus

<400> 7
Met Met Phe Ser Gly Phe Asn Ala Asp Tyr Glu Ala Ser Ser Ser Arg 
1               5                   10                  15      


Cys Ser Ser Ala Ser Pro Ala Gly Asp Ser Leu Ser Tyr Tyr His Ser 
            20                  25                  30          


Pro Ala Asp Ser Phe Ser Ser Met Gly Ser Pro Val Asn Thr Gln Asp 
        35                  40                  45              


Phe Cys Ala Asp Leu Ser Val Ser Ser Ala Asn Phe Ile Pro Thr Val 
    50                  55                  60                  


Thr Ala Ile Ser Thr Ser Pro Asp Leu Gln Trp Leu Val Gln Pro Thr 
65                  70                  75                  80  


Leu Val Ser Ser Val Ala Pro Ser Gln Thr Arg Ala Pro His Pro Tyr 
                85                  90                  95      


Gly Leu Pro Thr Gln Ser Ala Gly Ala Tyr Ala Arg Ala Gly Met Val 
            100                 105                 110         


Lys Thr Val Ser Gly Gly Arg Ala Gln Ser Ile Gly Arg Arg Gly Lys 
        115                 120                 125             


Val Glu Gln Leu Ser Pro Glu Glu Glu Glu Lys Arg Arg Ile Arg Arg 
    130                 135                 140                 


Glu Arg Asn Lys Met Ala Ala Ala Lys Cys Arg Asn Arg Arg Arg Glu 
145                 150                 155                 160 


Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp Glu Lys 
                165                 170                 175     


Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys Glu Lys 
            180                 185                 190         


Leu Glu Phe Ile Leu Ala Ala His Arg Pro Ala Cys Lys Ile Pro Asp 
        195                 200                 205             


Asp Leu Gly Phe Pro Glu Glu Met Ser Val Ala Ser Leu Asp Leu Thr 
    210                 215                 220                 


Gly Gly Leu Pro Glu Ala Ser Thr Pro Glu Ser Glu Glu Ala Phe Thr 
225                 230                 235                 240 


Leu Pro Leu Leu Asn Asp Pro Glu Pro Lys Pro Ser Leu Glu Pro Val 
                245                 250                 255     


Lys Ser Ile Ser Asn Val Glu Leu Lys Ala Glu Pro Phe Asp Asp Phe 
            260                 265                 270         


Leu Phe Pro Ala Ser Ser Arg Pro Ser Gly Ser Glu Thr Ser Arg Ser 
        275                 280                 285             


Val Pro Asp Val Asp Leu Ser Gly Ser Phe Tyr Ala Ala Asp Trp Glu 
    290                 295                 300                 


Pro Leu His Ser Asn Ser Leu Gly Met Gly Pro Met Val Thr Glu Leu 
305                 310                 315                 320 


Glu Pro Leu Cys Thr Pro Val Val Thr Cys Thr Pro Gly Cys Thr Thr 
                325                 330                 335     


Tyr Thr Ser Ser Phe Val Phe Thr Tyr Pro Glu Ala Asp Ser Phe Pro 
            340                 345                 350         


Ser Cys Ala Ala Ala His Arg Lys Gly Ser Ser Ser Asn Glu Pro Ser 
        355                 360                 365             


Ser Asp Ser Leu Ser Ser Pro Thr Leu Leu Ala Leu 
    370                 375                 380 


<210> 8
<211> 3565
<212> DNA
<213> Homo sapiens

<400> 8
gcagccgggc ggccgcagaa gcgcccaggc ccgcgcgcca cccctctggc gccaccgtgg       60

ttgagcccgt gacgtttaca ctcattcata aaacgcttgt tataaaagca gtggctgcgg      120

cgcctcgtac tccaaccgca tctgcagcga gcaactgaga agccaagact gagccggcgg      180

ccgcggcgca gcgaacgagc agtgaccgtg ctcctaccca gctctgcttc acagcgccca      240

cctgtctccg cccctcggcc cctcgcccgg ctttgcctaa ccgccacgat gatgttctcg      300

ggcttcaacg cagactacga ggcgtcatcc tcccgctgca gcagcgcgtc cccggccggg      360

gatagcctct cttactacca ctcacccgca gactccttct ccagcatggg ctcgcctgtc      420

aacgcgcagg taaggctggc ttcccgtcgc cgcggggccg ggggcttggg gtcgcggagg      480

aggagacacc gggcgggacg ctccagtaga tgagtagggg gctcccttgt gcctggaggg      540

aggctgccgt ggccggagcg gtgccggctc gggggctcgg gacttgctct gagcgcacgc      600

acgcttgcca tagtaagaat tggttccccc ttcgggaggc aggttcgttc tgagcaacct      660

ctggtctgca ctccaggacg gatctctgac attagctgga gcagacgtgt cccaagcaca      720

aactcgctaa ctagagcctg gcttcttcgg ggaggtggca gaaagcggca atcccccctc      780

ccccggcagc ctggagcacg gaggagggat gagggaggag ggtgcagcgg gcgggtgtgt      840

aaggcagttt cattgataaa aagcgagttc attctggaga ctccggagcg gcgcctgcgt      900

cagcgcagac gtcagggata tttataacaa accccctttc aagcaagtga tgctgaaggg      960

ataacgggaa cgcagcggca ggatggaaga gacaggcact gcgctgcgga atgcctggga     1020

ggaaaagggg gagacctttc atccaggatg agggacattt aagatgaaat gtccgtggca     1080

ggatcgtttc tcttcactgc tgcatgcggc actgggaact cgccccacct gtgtccggaa     1140

cctgctcgct cacgtcggct ttccccttct gttttgttct aggacttctg cacggacctg     1200

gccgtctcca gtgccaactt cattcccacg gtcactgcca tctcgaccag tccggacctg     1260

cagtggctgg tgcagcccgc cctcgtctcc tctgtggccc catcgcagac cagagcccct     1320

caccctttcg gagtccccgc cccctccgct ggggcttact ccagggctgg cgttgtgaag     1380

accatgacag gaggccgagc gcagagcatt ggcaggaggg gcaaggtgga acaggtgagg     1440

aactctagcg tactcttcct gggaatgtgg gggctgggtg ggaagcagcc ccggagatgc     1500

aggagcccag tacagaggat gaagccactg atggggctgg ctgcacatcc gtaactggga     1560

gccctggctc caagcccatt ccatcccaac tcagactctg agtctcaccc taagaagtac     1620

tctcatagtt tcttccctaa gtttcttacc gcatgctttc agactgggct cttctttgtt     1680

ctcttgctga ggatcttatt ttaaatgcaa gtcacaccta ttctgcaact gcaggtcaga     1740

aatggtttca cagtggggtg ccaggaagca gggaagctgc aggagccagt tctactgggg     1800

tgggtgaatg gaggtgatgg cagacacttt tactgaatgt cggtcttttt ttgtgattat     1860

tctagttatc tccagaagaa gaagagaaaa ggagaatccg aagggaaagg aataagatgg     1920

ctgcagccaa atgccgcaac cggaggaggg agctgactga tacactccaa gcggtaggta     1980

ctctgtgggt tgctcctttt taaaacttaa gggaaagttg gagattgagc ataagggccc     2040

ttgagtaaga ctgtgtctta tgctttcctt tatccctctg tatacaggag acagaccaac     2100

tagaagatga gaagtctgct ttgcagaccg agattgccaa cctgctgaag gagaaggaaa     2160

aactagagtt catcctggca gctcaccgac ctgcctgcaa gatccctgat gacctgggct     2220

tcccagaaga gatgtctgtg gcttcccttg atctgactgg gggcctgcca gaggttgcca     2280

ccccggagtc tgaggaggcc ttcaccctgc ctctcctcaa tgaccctgag cccaagccct     2340

cagtggaacc tgtcaagagc atcagcagca tggagctgaa gaccgagccc tttgatgact     2400

tcctgttccc agcatcatcc aggcccagtg gctctgagac agcccgctcc gtgccagaca     2460

tggacctatc tgggtccttc tatgcagcag actgggagcc tctgcacagt ggctccctgg     2520

ggatggggcc catggccaca gagctggagc ccctgtgcac tccggtggtc acctgtactc     2580

ccagctgcac tgcttacacg tcttccttcg tcttcaccta ccccgaggct gactccttcc     2640

ccagctgtgc agctgcccac cgcaagggca gcagcagcaa tgagccttcc tctgactcgc     2700

tcagctcacc cacgctgctg gccctgtgag ggggcaggga aggggaggca gccggcaccc     2760

acaagtgcca ctgcccgagc tggtgcatta cagagaggag aaacacatct tccctagagg     2820

gttcctgtag acctagggag gaccttatct gtgcgtgaaa cacaccaggc tgtgggcctc     2880

aaggacttga aagcatccat gtgtggactc aagtccttac ctcttccgga gatgtagcaa     2940

aacgcatgga gtgtgtattg ttcccagtga cacttcagag agctggtagt tagtagcatg     3000

ttgagccagg cctgggtctg tgtctctttt ctctttctcc ttagtcttct catagcatta     3060

actaatctat tgggttcatt attggaatta acctggtgct ggatattttc aaattgtatc     3120

tagtgcagct gattttaaca ataactactg tgttcctggc aatagtgtgt tctgattaga     3180

aatgaccaat attatactaa gaaaagatac gactttattt tctggtagat agaaataaat     3240

agctatatcc atgtactgta gtttttcttc aacatcaatg ttcattgtaa tgttactgat     3300

catgcattgt tgaggtggtc tgaatgttct gacattaaca gttttccatg aaaacgtttt     3360

attgtgtttt taatttattt attaagatgg attctcagat atttatattt ttattttatt     3420

tttttctacc ttgaggtctt ttgacatgtg gaaagtgaat ttgaatgaaa aatttaagca     3480

ttgtttgctt attgttccaa gacattgtca ataaaagcat ttaagttgaa tgcgaccaac     3540

cttgtgctct tttcattctg gaagt                                           3565


<210> 9
<211> 3967
<212> DNA
<213> Mus musculus

<400> 9
ataccagaga ctcaaaaaaa aaaaaaaagt tccagattgc tggacaatga cccgggtctc       60

atcccttgac cctgggaacc gggtccacat tgaatcaggt gcgaatgttc gctcgccttc      120

tctgcctttc ccgcctcccc tcccccggcc gcggccccgg ttccccccct gcgctgcacc      180

ctcagagttg gctgcagccg gcgagctgtt cccgtcaatc cctccctcct ttacacagga      240

tgtccatatt aggacatctg cgtcagcagg tttccacggc cggtccctgt tgttctgggg      300

gggggaccat ctccgaaatc ctacacgcgg aaggtctagg agacccccta agatcccaaa      360

tgtgaacact cataggtgaa agatgtatgc caagacgggg gttgaaagcc tggggcgtag      420

agttgacgac agagcgcccg cagagggcct tggggcgcgc ttcccccccc ttccagttcc      480

gcccagtgac gtaggaagtc catccattca cagcgcttct ataaaggcgc cagctgaggc      540

gcctactact ccaaccgcga ctgcagcgag caactgagaa gactggatag agccggcggt      600

tccgcgaacg agcagtgacc gcgctcccac ccagctctgc tctgcagctc ccaccagtgt      660

ctacccctgg accccttgcc gggctttccc caaacttcga ccatgatgtt ctcgggtttc      720

aacgccgact acgaggcgtc atcctcccgc tgcagtagcg cctccccggc cggggacagc      780

ctttcctact accattcccc agccgactcc ttctccagca tgggctctcc tgtcaacaca      840

caggtgagtt tggctttgtg tagccgccag gtccgcgctg agggtcgccg tggaggagac      900

actggggtgt gactcgcagg ggcggggggg tcttcctttt tcgctctgga gggagactgg      960

cgcggtcaga gcagccttag cctgggaacc caggacttgt ctgagcgcgt gcacacttgt     1020

catagtaaga cttagtgacc ccttcccgcg cggcaggttt attctgagtg gcctgcctgc     1080

attcttctct cggccgactt gtttctgaga tcagccgggg ccaacaagtc tcgagcaaag     1140

agtcgctaac tagagtttgg gaggcggcaa accgcggcaa tcccccctcc cggggcagcc     1200

tggagcaggg aggagggagg agggaggagg gtgctgcggg cgggtgtgta aggcagtttc     1260

attgataaaa agcgagttca ttctggagac tccggagcag cgcctgcgtc agcgcagacg     1320

tcagggatat ttataacaaa ccccctttcg agcgagtgat gccgaaggga taacgggaac     1380

gcagcagtag gatggaggag aaaggctgcg ctgcggaatt caagggagga tattgggaga     1440

gcttttatct ccgatgaggt gcatacagga agacataagc agtctctgac cggaatgctt     1500

ctctctccct gcttcatgcg acactagggc cacttgctcc acctgtgtct ggaacctcct     1560

cgctcacctc cgctttcctc tttttgtttt gtttcaggac ttttgcgcag atctgtccgt     1620

ctctagtgcc aactttatcc ccacggtgac agccatctcc accagcccag acctgcagtg     1680

gctggtgcag cccactctgg tctcctccgt ggccccatcg cagaccagag cgccccatcc     1740

ttacggactc cccacccagt ctgctggggc ttacgccaga gcgggaatgg tgaagaccgt     1800

gtcaggaggc agagcgcaga gcatcggcag aaggggcaaa gtagagcagg tgagcagcga     1860

ttctggacct ttgtgggctg gggggggggg ggggggcgga gactgacgca cagaccacac     1920

aacagagaag ggacgctact gactgcactt cctgaccagg agctgtggct gctagccctt     1980

tccctccctt gtcagatttt gacagttgga cccaagacaa actctagaca gtttccctga     2040

cagcttccta cttcattctc tagccgggga gcttctttgt tcccctgcta aagatctcac     2100

tttaaatgca aatcacactc tgcctgccaa ctgcaggtta gaaaaactgc ttcaccgaga     2160

ggtgcgggtg ctgtaggagc cagtttcact ggggtgactg aatggaggtg acactagaca     2220

accttaactg aatgttggtc cttttcttct atagctatct cctgaagagg aagagaaacg     2280

gagaatccga agggaacgga ataagatggc tgcagccaag tgccggaatc ggaggaggga     2340

gctgacagat acactccaag cggtaggttg aaccagctgc tgctcctgaa actttattaa     2400

agttggagct tgggactatg ggcgcagggt ccttgagcat gcccgtgtct tatgctttct     2460

tatatctctc cctatgcagg agacagatca acttgaagat gagaagtctg cgttgcagac     2520

tgagattgcc aatctgctga aagagaagga aaaactggag tttattttgg cagcccaccg     2580

acctgcctgc aagatccccg atgaccttgg cttcccagag gagatgtctg tggcctccct     2640

ggatttgact ggaggtctgc ctgaggcttc caccccagag tctgaggagg ccttcaccct     2700

gccccttctc aacgaccctg agcccaagcc atccttggag ccagtcaaga gcatcagcaa     2760

cgtggagctg aaggcagaac cctttgatga cttcttgttt ccggcatcat ctaggcccag     2820

tggctcagag acctcccgct ctgtgccaga tgtggacctg tccggttcct tctatgcagc     2880

agactgggag cctctgcaca gcaattcctt ggggatgggg cccatggtca cagagctgga     2940

gcccctgtgt actcccgtgg tcacctgtac tccgggctgc actacttaca cgtcttcctt     3000

tgtcttcacc taccctgaag ctgactcctt cccaagctgt gccgctgccc accgaaaggg     3060

cagcagcagc aacgagccct cctccgactc cctgagctca cccacgctgc tggccctgtg     3120

agcagtcaga gaaggcaagg cagccggcat ccagacgtgc cactgcccga gctggtgcat     3180

tacagagagg agaaacacgt cttccctcga aggttcccgt cgacctaggg aggaccttac     3240

ctgttcgtga aacacaccag gctgtgggcc tcaaggactt gcaagcatcc acatctggcc     3300

tccagtcctc acctcttcca gagatgtagc aaaaacaaaa caaaacaaaa caaaaaaccg     3360

catggagtgt gttgttccta gtgacacctg agagctggta gttagtagag catgtgagtc     3420

aaggcctggt ctgtgtctct tttctctttc tccttagttt tctcatagca ctaactaatc     3480

tgttgggttc attattggaa ttaacctggt gctggattgt atctagtgca gctgatttta     3540

acaataccta ctgtgttcct ggcaatagcg tgttccaatt agaaacgacc aatattaaac     3600

taagaaaaga taggacttta ttttccagta gatagaaatc aatagctata tccatgtact     3660

gtagtccttc agcgtcaatg ttcattgtca tgttactgat catgcattgt cgaggtggtc     3720

tgaatgttct gacattaaca gttttccatg aaaacgtttt tattgtgttt tcaatttatt     3780

tattaagatg gattctcaga tatttatatt tttattttat ttttttctac cctgaggtct     3840

ttcgacatgt ggaaagtgaa tttgaatgaa aaattttaag cattgtttgc ttattgttcc     3900

aggacattgt caataaaagc atttaagttg aatgcgacca ccttcttgct ctctttattc     3960

tcagttt                                                               3967


<210> 10
<211> 3198
<212> DNA
<213> Homo sapiens


<220>
<221> modified_base
<222> (266)..(266)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (326)..(326)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (410)..(410)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (517)..(517)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (546)..(546)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (566)..(567)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (588)..(589)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (592)..(592)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (653)..(653)
<223> a, c, t, g, unknown or other

<400> 10
cctcgaggtc gaagcttatt taaaagcata ttttccaatg cctgctttag ctgtggaaaa       60

ggaagactct ccgagggcaa atccaggagt catggaaaac aatgggcagg gcagcttggt      120

gctgtgactg gatgggtctt taaggttgtt tcccttgaat aaagaatgag ggaattccac      180

caggggaagg agagtagacc aaacatttgg tgaacagaaa gggagacaga gtctttagtg      240

ttattcccca aatattcctg gagagncctt tgagacacct ggtaggatta tagtgatcta      300

aagaggcatg gccatgtgac tgcttnggcc aatgatgtat gggcagaagt gatgtgtgcc      360

ataagtggat gctctgacag acatgatgtt ccgagttcct tccccacagn caggatagct      420

gtgaaaaggg gtatcaacac gaggcctcct tcagcctgag ccctttagtg actacaatga      480

gcagagctac cctgccaacc tacaacggtc atgtagnaga aatgaccaac tttcactgga      540

ataagncact gatatgttag ggttgnntgg tagggcagca taacactnnc tntcctgaca      600

gaactgggag tgagagataa ggctggagag agaaggagtt ggattgtgaa aanccccttc      660

tccaaggcat aggaatcgga actctcctga ttgtaaggaa aagccaatga aggcttccaa      720

gcaggggcgt taacatgaac agatttgtta tttttttgga tgaaatatgc tatttctcaa      780

cataaggaga agatcagcct actaaaccac atgaggcaga gaggaacaca cagaacctta      840

gccaaaagat atatatttat gcaaagtcct aagtcttgaa atttctaaat acaggagctc      900

tgaacggagt tacagtcaga ggatcaggca agaaaatttc ttctatgcca caagcgctat      960

ttcctctgca gataactaat actccacaag aaagtttgcc agagtagaga aaatacaaag     1020

gaatgtaaca cagacctgag gtcaatttcc agctgcctgt gtgacctcaa caaagatact     1080

taacctctct gggcctattt cctcacatgt taaatctgga taataatata tgtctctcaa     1140

gacagttgtg gggagaaaac agcgtattta aattgcttag gagaatgcct ggcagataat     1200

aagtgtttaa tacatgaaac tgatttttat tactgttatt aaaaaatatt tagaacacca     1260

actccctgaa tacaacagaa aatgattcag ggcaacagac agaggagaat gttctctcct     1320

tgaggaagca actggatctt gtcatcactg tatacctacc taccccaccc cctccccagc     1380

tcagtgcctg gctcacagta ggctttcagt taccctctgc agatcagtga aagctaggtg     1440

agtgcccgga gtgaagaaaa gttggcaggt ttcccactga taccagctgc tgttggtttc     1500

tgaacactca aagccgcaaa taccttaggg ctgggggcaa tgaacccaag gctgaattcc     1560

aagttcagaa gcagcgaagt ctgaatttag aacctaggac ttaaactgct gcaggtccaa     1620

cttcaagccc cagttttaga cagaggcttg ggaaagatct gacttctaac ccggttcccc     1680

ctcccctcct cccctcgatg cttctcacag gaaagtacac ctggtcctgc caaatcgcac     1740

tcttatatcc tggcatccta tccaggctct gcgaggatgg aaactgcgag gcaggggagg     1800

gaagcgggct gtttggccac cacctcccta gtgctgcagg cgaccctgtc acactaaact     1860

cctggcagcc cagtgaggtg gacggcaccg ccccacctgc agatgaggga aatgaagctc     1920

ggaggagttc cgtgatttgc ttgcttcaca ctgtggtagc ctggccacga aagaaccaag     1980

gattccgact tcggattctt ccaccacaca ctttcgtcct aagggtgggg gcggggggag     2040

aataaaataa ccgcggaaaa ggaaccactt acatgtgtct agcgcttcct agaggctacc     2100

caggatatgc gcccaccacc cggccggagt gcagagattt gaagtccagg ttctaccccg     2160

ggctccgagt actactgcgt gactttatgc gagtgtcgcc gccttctggg cttgttttcc     2220

cggaagcaac tcggcgcgga tggagtgtgt gtgtgcgcgc gcgcgttatg ttgtgcgtgt     2280

tgtgttagcg tgtgcgtgtt gtccgagttt cggatcgcct acacctgtga acccccgcgc     2340

cctttccccc acggtcccgg agatgaagtg gggtgcaacg gagactcagc tgagcgtcca     2400

gtttcgggca atacaaatct ctcggcttct acgagcagcc acacgacccc gcggaccgtc     2460

gctcctgaac ttgaccgaga tgcaaacttc ggagtgttct caacgtgggg gccgactctc     2520

ggagaccgcc ctaaacttaa gtccccttag gctcgcccca cctggacttc acatagccac     2580

cttaagggcg gtattcccgc ccccggaagt gcgggtggca gcgtacttgg attctcagcc     2640

tccagccccg cgcggtggcg gccgcggtgg atgacttcgg gccccacaag tggaaacaac     2700

aaccacccct cgcccgcacc cctggcccaa aacaactggc caggttccct cgtcccgggt     2760

ccctgcatcc cccgcatccc cgtccgcagc cgtgaacttg agcccccctc catcagaggt     2820

tgcgagcgtc gccgctcggc agccaccgtc actagacagt caaaccccaa gacgtcagcc     2880

cacaatgcac cgggcgggcc gggaaaaacg gcccggggag gggaccgggg aacagagggc     2940

cgagaggcgt gcggcagggg ggagggtagg agaaagaagg gcccgactgt aggagggcag     3000

cggagcatta cctcatcccg tgagcctccg cgggcccaga gaagaatctt ctagggtgga     3060

gtctccatgg tgacgggcgg gcccgccccc ctgagagcga cgcgagccaa tgggaaggcc     3120

ttggggtgac atcatgggct atttttaggg gttgactggt agcagataag tgttgagctc     3180

gggctggata agggctca                                                   3198


<210> 11
<211> 3338
<212> DNA
<213> Homo sapiens

<400> 11
gacatcatgg gctattttta ggggttgact ggtagcagat aagtgttgag ctcgggctgg       60

ataagggctc agagttgcac tgagtgtggc tgaagcagcg aggcgggagt ggaggtgcgc      120

ggagtcaggc agacagacag acacagccag ccagccaggt cggcagtata gtccgaactg      180

caaatcttat tttcttttca ccttctctct aactgcccag agctagcgcc tgtggctccc      240

gggctggtgt ttcgggagtg tccagagagc ctggtctcca gccgcccccg ggaggagagc      300

cctgctgccc aggcgctgtt gacagcggcg gaaagcagcg gtacccacgc gcccgccggg      360

ggaagtcggc gagcggctgc agcagcaaag aactttcccg gctgggagga ccggagacaa      420

gtggcagagt cccggagcga acttttgcaa gcctttcctg cgtcttaggc ttctccacgg      480

cggtaaagac cagaaggcgg cggagagcca cgcaagagaa gaaggacgtg cgctcagctt      540

cgctcgcacc ggttgttgaa cttgggcgag cgcgagccgc ggctgccggg cgccccctcc      600

ccctagcagc ggaggagggg acaagtcgtc ggagtccggg cggccaagac ccgccgccgg      660

ccggccactg cagggtccgc actgatccgc tccgcgggga gagccgctgc tctgggaagt      720

gagttcgcct gcggactccg aggaaccgct gcgcccgaag agcgctcagt gagtgaccgc      780

gacttttcaa agccgggtag cgcgcgcgag tcgacaagta agagtgcggg aggcatctta      840

attaaccctg cgctccctgg agcgagctgg tgaggagggc gcagcgggga cgacagccag      900

cgggtgcgtg cgctcttaga gaaactttcc ctgtcaaagg ctccgggggg cgcgggtgtc      960

ccccgcttgc cagagccctg ttgcggcccc gaaacttgtg cgcgcagccc aaactaacct     1020

cacgtgaagt gacggactgt tctatgactg caaagatgga aacgaccttc tatgacgatg     1080

ccctcaacgc ctcgttcctc ccgtccgaga gcggacctta tggctacagt aaccccaaga     1140

tcctgaaaca gagcatgacc ctgaacctgg ccgacccagt ggggagcctg aagccgcacc     1200

tccgcgccaa gaactcggac ctcctcacct cgcccgacgt ggggctgctc aagctggcgt     1260

cgcccgagct ggagcgcctg ataatccagt ccagcaacgg gcacatcacc accacgccga     1320

cccccaccca gttcctgtgc cccaagaacg tgacagatga gcaggagggc ttcgccgagg     1380

gcttcgtgcg cgccctggcc gaactgcaca gccagaacac gctgcccagc gtcacgtcgg     1440

cggcgcagcc ggtcaacggg gcaggcatgg tggctcccgc ggtagcctcg gtggcagggg     1500

gcagcggcag cggcggcttc agcgccagcc tgcacagcga gccgccggtc tacgcaaacc     1560

tcagcaactt caacccaggc gcgctgagca gcggcggcgg ggcgccctcc tacggcgcgg     1620

ccggcctggc ctttcccgcg caaccccagc agcagcagca gccgccgcac cacctgcccc     1680

agcagatgcc cgtgcagcac ccgcggctgc aggccctgaa ggaggagcct cagacagtgc     1740

ccgagatgcc cggcgagaca ccgcccctgt cccccatcga catggagtcc caggagcgga     1800

tcaaggcgga gaggaagcgc atgaggaacc gcatcgctgc ctccaagtgc cgaaaaagga     1860

agctggagag aatcgcccgg ctggaggaaa aagtgaaaac cttgaaagct cagaactcgg     1920

agctggcgtc cacggccaac atgctcaggg aacaggtggc acagcttaaa cagaaagtca     1980

tgaaccacgt taacagtggg tgccaactca tgctaacgca gcagttgcaa acattttgaa     2040

gagagaccgt cgggggctga ggggcaacga agaaaaaaaa taacacagag agacagactt     2100

gagaacttga caagttgcga cggagagaaa aaagaagtgt ccgagaacta aagccaaggg     2160

tatccaagtt ggactgggtt gcgtcctgac ggcgccccca gtgtgcacga gtgggaagga     2220

cttggcgcgc cctcccttgg cgtggagcca gggagcggcc gcctgcgggc tgccccgctt     2280

tgcggacggg ctgtccccgc gcgaacggaa cgttggactt ttcgttaaca ttgaccaaga     2340

actgcatgga cctaacattc gatctcattc agtattaaag gggggagggg gagggggtta     2400

caaactgcaa tagagactgt agattgcttc tgtagtactc cttaagaaca caaagcgggg     2460

ggagggttgg ggaggggcgg caggagggag gtttgtgaga gcgaggctga gcctacagat     2520

gaactctttc tggcctgcct tcgttaactg tgtatgtaca tatatatatt ttttaatttg     2580

atgaaagctg attactgtca ataaacagct tcatgccttt gtaagttatt tcttgtttgt     2640

ttgtttgggt atcctgccca gtgttgtttg taaataagag atttggagca ctctgagttt     2700

accatttgta ataaagtata taattttttt atgttttgtt tctgaaaatt ccagaaagga     2760

tatttaagaa aatacaataa actattggaa agtactcccc taacctcttt tctgcatcat     2820

ctgtagatac tagctatcta ggtggagttg aaagagttaa gaatgtcgat taaaatcact     2880

ctcagtgctt cttactatta agcagtaaaa actgttctct attagacttt agaaataaat     2940

gtacctgatg tacctgatgc tatggtcagg ttatactcct cctcccccag ctatctatat     3000

ggaattgctt accaaaggat agtgcgatgt ttcaggaggc tggaggaagg ggggttgcag     3060

tggagaggga cagcccactg agaagtcaaa catttcaaag tttggattgt atcaagtggc     3120

atgtgctgtg accatttata atgttagtag aaattttaca ataggtgctt attctcaaag     3180

caggaattgg tggcagattt tacaaaagat gtatccttcc aatttggaat cttctctttg     3240

acaattccta gataaaaaga tggcctttgc ttatgaatat ttataacagc attcttgtca     3300

caataaatgt attcaaatac caaaaaaaaa aaaaaaaa                             3338


<210> 12
<211> 331
<212> PRT
<213> Homo sapiens

<400> 12
Met Thr Ala Lys Met Glu Thr Thr Phe Tyr Asp Asp Ala Leu Asn Ala 
1               5                   10                  15      


Ser Phe Leu Pro Ser Glu Ser Gly Pro Tyr Gly Tyr Ser Asn Pro Lys 
            20                  25                  30          


Ile Leu Lys Gln Ser Met Thr Leu Asn Leu Ala Asp Pro Val Gly Ser 
        35                  40                  45              


Leu Lys Pro His Leu Arg Ala Lys Asn Ser Asp Leu Leu Thr Ser Pro 
    50                  55                  60                  


Asp Val Gly Leu Leu Lys Leu Ala Ser Pro Glu Leu Glu Arg Leu Ile 
65                  70                  75                  80  


Ile Gln Ser Ser Asn Gly His Ile Thr Thr Thr Pro Thr Pro Thr Gln 
                85                  90                  95      


Phe Leu Cys Pro Lys Asn Val Thr Asp Glu Gln Glu Gly Phe Ala Glu 
            100                 105                 110         


Gly Phe Val Arg Ala Leu Ala Glu Leu His Ser Gln Asn Thr Leu Pro 
        115                 120                 125             


Ser Val Thr Ser Ala Ala Gln Pro Val Asn Gly Ala Gly Met Val Ala 
    130                 135                 140                 


Pro Ala Val Ala Ser Val Ala Gly Gly Ser Gly Ser Gly Gly Phe Ser 
145                 150                 155                 160 


Ala Ser Leu His Ser Glu Pro Pro Val Tyr Ala Asn Leu Ser Asn Phe 
                165                 170                 175     


Asn Pro Gly Ala Leu Ser Ser Gly Gly Gly Ala Pro Ser Tyr Gly Ala 
            180                 185                 190         


Ala Gly Leu Ala Phe Pro Ala Gln Pro Gln Gln Gln Gln Gln Pro Pro 
        195                 200                 205             


His His Leu Pro Gln Gln Met Pro Val Gln His Pro Arg Leu Gln Ala 
    210                 215                 220                 


Leu Lys Glu Glu Pro Gln Thr Val Pro Glu Met Pro Gly Glu Thr Pro 
225                 230                 235                 240 


Pro Leu Ser Pro Ile Asp Met Glu Ser Gln Glu Arg Ile Lys Ala Glu 
                245                 250                 255     


Arg Lys Arg Met Arg Asn Arg Ile Ala Ala Ser Lys Cys Arg Lys Arg 
            260                 265                 270         


Lys Leu Glu Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys 
        275                 280                 285             


Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln 
    290                 295                 300                 


Val Ala Gln Leu Lys Gln Lys Val Met Asn His Val Asn Ser Gly Cys 
305                 310                 315                 320 


Gln Leu Met Leu Thr Gln Gln Leu Gln Thr Phe 
                325                 330     


<210> 13
<211> 3296
<212> DNA
<213> Mus musculus


<220>
<221> modified_base
<222> (19)..(19)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (35)..(35)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (40)..(41)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (45)..(45)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (51)..(51)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (61)..(61)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (63)..(65)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (75)..(75)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (84)..(84)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (88)..(88)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (92)..(92)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (97)..(97)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (103)..(103)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (113)..(113)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (124)..(124)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (128)..(128)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (148)..(148)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (155)..(155)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (164)..(164)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (191)..(191)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (199)..(200)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (204)..(204)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (206)..(206)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (227)..(227)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (241)..(241)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (270)..(270)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (290)..(290)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (294)..(294)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (326)..(326)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (368)..(368)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (370)..(370)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (394)..(394)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (416)..(416)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (525)..(525)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (548)..(548)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (582)..(582)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (709)..(709)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (720)..(720)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (833)..(833)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (836)..(836)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (929)..(929)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1518)..(1518)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1527)..(1527)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1556)..(1556)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1583)..(1583)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1609)..(1609)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1618)..(1618)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1633)..(1633)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1655)..(1655)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1686)..(1687)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1691)..(1691)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1699)..(1699)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1709)..(1709)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1728)..(1728)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1731)..(1732)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1738)..(1739)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1759)..(1760)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1775)..(1775)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1781)..(1781)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1789)..(1789)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1804)..(1804)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1806)..(1807)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1845)..(1845)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1849)..(1849)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1890)..(1890)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1902)..(1902)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (1913)..(1913)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (2015)..(2015)
<223> a, c, t, g, unknown or other

<400> 13
aattctttgg ccgcttggna ntttggaaat ccctnggaan nccangggga nccagccctt       60

ntnnnggggt tccantccag cttnaagncc cnaggcnatc ctncaaaggt ttncccaaaa      120

gaancccnac acctttataa aaccccancc aagcntttgg taantccttt ggaagcttga      180

ggccaacccc ncaggggcnn aagnanccca aacccccaag aagaccnggc ttttattttc      240

nagaagtggc tgcctgggag agttccttgn aaatactcaa gttctatcan tttnctgggt      300

ctcttgttcc cttccttcgc caagcnaacc tctgtcctcc gcccctataa tacatgttga      360

atgggttncn gggtacctct acctcagagg gagncacaca tttggacctg atgtgntctc      420

tattcactac ctctccaaag cctggatgta aactttatcc tgtaactgaa ggttgttttc      480

agctgattcc tctttagaag gaaagaatgc aggaaggacc ccttncagac cctcactctc      540

aggcatgncc aagtgactgg cttttgacag tggcatgaga ancgatgggt tccacttcta      600

ggtcaatact ctaagagcca gtgttttgct aagttccccc tttagtcaaa gccgacaggg      660

ctccctgcat agccacagtg ggcaagtaat tggaggaagc aagaaacana cattcatcan      720

cctttgggat gttgggttct tctttagggt ggcatacccc agcccttccc aactgagctt      780

ccagcacgat atgsctaaaa agagcagaag ctgggttgtg gagaaactaa aancanaaac      840

ccaaaaacca gaaaaaaacc cttcctccca gccaaagagg aagtttatga tccaagcagc      900

agcattaaca agagcaggga tctgtttcnc cttggatgaa rctgctattt ctttacctaa      960

gtaggaaatc agcctcttaa gccacaggag gcagaagatg cacagaaccc ttgggcaaaa     1020

gatacataat tacacgaggg cctaggatct gggagtttct aaatacagga acaacaaaac     1080

aaagtctatg ccatcagcac caatttccga gcaaataact aagactttaa gggaaagttt     1140

gccagagtag aaaaaaatac aaagggatgt aacacagacc tgagatcact ttccagctgt     1200

ctgtataccc tgagcaagac gcatggactt tctgggatag tttcctccca tgtaaagtct     1260

aggtaaaaat gtatgcttct taagataact gtgggaagaa aacagcatac ttaaactgct     1320

tggagtaact ggcagatagg tggtgtttag tggacgaaac ttattttatt actgttatca     1380

taaatcatgt taagtatgag ctccttggca aaaaaaaaaa aaaaaaatag ggctgcggac     1440

agaggaactc ggtttccatt tgggggaagt aaatggctct agacttcaca gaaaccctgc     1500

tctaccctgc ccccaccnag gtcagcnctt gactggtagc agccagttac cctctncacc     1560

cgggagtgaa tgaagacctg gcnggtttcc caccgatgcc agctgctant gggtctgnct     1620

gctctcaaag ctngaaagga agtgagtgct gctgnacctt gagttctgag ccaccaaagc     1680

ccaaannaga ncctttctng gcccaactnc aaacttcaag tcctaggntg nngggagnnt     1740

taagggaaga gttgcctcnn ggtccttttt ctatntcgct nggggcctnc tcccaaatct     1800

caancnngga tcctccaaat caccccaccc ccaccccacc ggcgncccng gtaactccga     1860

agctggtagg gaaggggcct attctcagan ccaaaactaa tncctgccag ccngttgtag     1920

tggacctcat tcgctctact tctagatgag accaataaag ctcagagaag ttctgagatt     1980

tgcccttatg ccctgggaga accaagcttg ccacntcttt agtcctgagg ggtggagggt     2040

ggagggctga tagcagaacc ttagaaaaga aataacttac atgtgtctag cgcttcctag     2100

aggccgcaca ggatatgact ccaccagtga gcggggaggg gagttttcag cctgtttcta     2160

ccagggactc ctgcttaagc accgtgactt ggggcgagtc cgcagctctc aaggcttgtt     2220

ttcccagaag caaatcaggg agggaggaag ggcgggcgca gactgagtgt gcgcgggacc     2280

gtgtgtatgt gctagcgcag gcgatcgccg aggtttcctg agtttcgaac ctttatatgt     2340

tgctttcgac accccatggg cgctgggcta gcatctttca cacctagagg aggggtccct     2400

cggaggcaaa gcgaacaccc ctcccccggc acgtccagag aataaagtgt tgtgccgggg     2460

accctgatga gtcggttccg aacaccgcaa atctctggtt tccaggtaca gcacactgcg     2520

gcgcagatcc ttctccgaaa ctaaacttcc aagcatactc atcttggagg gctactctca     2580

agcccgctca acttcaacgc acttacgtgc tcccacaccc agggcgcaca caaccctttt     2640

aacccgcatc gctctgtccc ccggaagtgc gggggtgcgg agccagcttc agtcactcag     2700

atcattcagc cctttctcgg gcgtgcgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt     2760

gtgtgtgtgc ccgcgcgcgg gcgcgcgcct gtgtgcaacc ttcactccca cccaagctct     2820

ccgcccccgg ccactagcgc gcctcccctg ctttctggat cccccgcgtc tcggtcccag     2880

tccccagccc tgaacttgag cccgcctccg acagactccg caaggtcctg ccgacccggc     2940

agcctccgtc actagacagc caaaccaaga cgtcagccca caatgcaccg ggcgggccgg     3000

gaaagactcg tgccggggag ggaacccggg aacacaagcc gaagctgagc gcgggagggg     3060

ggggggagga ggagaaagaa gggcccaact gtaggagcgc agcagcatta cctcatccgt     3120

gagccttcgc ggcccagaga agaatcttct agggtgaggt ctccatggcg acgggtgggc     3180

ccgcccccct gagaacgacg caagccaatg ggaaagcctc ggggtgacat catgggctat     3240

ttttagggat tgactggtag cagataagtg ttgagctcag gctggataag gactca         3296


<210> 14
<211> 3187
<212> DNA
<213> Mus musculus

<400> 14
gttgagctca ggctggataa ggactcagag ttgcactgag tgtggcagag acagcctggc       60

aggagagcgc tcaggcagac agacagacag acggacggac ttggccaacc cggtcggccg      120

cggactccgg actgttcatc cgtttgtctt cattttctca ccaactgctt ggatccagcg      180

cccgcggctc ctgcaccggt attttgggga gcatttggag agtcccttct cccgccttcc      240

acggagaaga agctcacaag tccgggcgct gctgacagca tcgagagcgg ctcccgaccg      300

cgcgaggaaa taggcgagcg gctaccggcc agcaactttc ctgacccaga ggaccggtaa      360

caagtggccg ggagcgaact tttgcaaatc tcttctgcgc cttaaggctg ccaccgagac      420

tgtaaagaaa agggagaaga ggaacctata ctcataccag ttcgcacagg cggctgaagt      480

tgggcgagcg ctagccgcgg ctgcctagcg tccccctccc cctcacagcg gaggagggga      540

cagttgtcgg aggccgggcg gcagagcccg atcgcgggct tccaccgaga attccgtgac      600

gactggtcag caccgccgga gagccgctgt tgctgggact ggtctgcggg ctccaaggaa      660

ccgctgctcc ccgagagcgc tccgtgagtg accgcgactt ttcaaagctc ggcatcgcgc      720

gggagcctac caacgtgagt gctagcggag tcttaaccct gcgctccctg gagcgaactg      780

gggaggaggg ctcaggggga agcactgccg tctggagcgc acgctcctaa acaaactttg      840

ttacagaagc ggggacgcgc gggtatcccc ccgcttcccg gcgcgctgtt gcggccccga      900

aacttctgcg cacagcccag gctaaccccg cgtgaagtga cggaccgttc tatgactgca      960

aagatggaaa cgaccttcta cgacgatgcc ctcaacgcct cgttcctcca gtccgagagc     1020

ggtgcctacg gctacagtaa ccctaagatc ctaaaacaga gcatgacctt gaacctggcc     1080

gacccggtgg gcagtctgaa gccgcacctc cgcgccaaga actcggacct tctcacgtcg     1140

cccgacgtcg ggctgctcaa gctggcgtcg ccggagctgg agcgcctgat catccagtcc     1200

agcaatgggc acatcaccac tacaccgacc cccacccagt tcttgtgccc caagaacgtg     1260

accgacgagc aggagggctt cgccgagggc ttcgtgcgcg ccctggctga actgcatagc     1320

cagaacacgc ttcccagtgt cacctccgcg gcacagccgg tcagcggggc gggcatggtg     1380

gctcccgcgg tggcctcagt agcaggcgct ggcggcggtg gtggctacag cgccagcctg     1440

cacagtgagc ctccggtcta cgccaacctc agcaacttca acccgggtgc gctgagcagc     1500

ggcggtgggg cgccctccta tggcgcggcc gggctggcct ttccctcgca gccgcagcag     1560

cagcagcagc cgcctcagcc gccgcaccac ttgccccaac agatcccggt gcagcacccg     1620

cggctgcaag ccctgaagga agagccgcag accgtgccgg agatgccggg agagacgccg     1680

cccctgtccc ctatcgacat ggagtctcag gagcggatca aggcagagag gaagcgcatg     1740

aggaaccgca ttgccgcctc caagtgccgg aaaaggaagc tggagcggat cgctcggcta     1800

gaggaaaaag tgaaaacctt gaaagcgcaa aactccgagc tggcatccac ggccaacatg     1860

ctcagggaac aggtggcaca gcttaagcag aaagtcatga accacgttaa cagtgggtgc     1920

caactcatgc taacgcagca gttgcaaacg ttttgagaac agactgtcag ggctgagggg     1980

caatggaaga aaaaaaataa cagagacaaa cttgagaact tgactggttg cgacagagaa     2040

aaaaaaagtg tccgagtact gaagccaagg gtacacaaga tggactgggt tgcgacctga     2100

cggcgccccc agtgtgctgg agtgggaagg acgtggcgcg cctggctttg gcgtggagcc     2160

agagagcagc ggcctattgg ccggcagact ttgcggacgg gctgtgcccg cgcgcgacca     2220

gaacgatgga cttttcgtta acattgacca agaactgcat ggacctaaca ttcgatctca     2280

ttcagtatta aaggggggtg ggaggggtta caaactgcaa tagagactgt agattgcttc     2340

tgtagtgctc cttaacacaa agcagggagg gctgggaagg ggggggaggc ttgtaagtgc     2400

caggctagac tgcagatgaa ctcccctggc ctgcctctct caactgtgta tgtacatata     2460

tatttttttt taatttgatg aaagctgatt actgtcaata aacagcttcc tgcctttgta     2520

agttattcca tgtttgtttg tttgggtgtc ctgcccagtg tttgtaaata agagatttga     2580

agcattctga gtttaccatt tgtaataaag tatataattt ttttatgttt tgtttctgaa     2640

aatttccaga aaggatattt aagaaaatac aataaactat tgaaaagtag cccccaacct     2700

ctttgctgca ttatccatag ataatgatag ctagatgaag tgacagctga gtgcccaata     2760

tactagggtg aaagctgtgt cccctgtctg attgtaggaa tagataccct gcatgctatc     2820

attggctcat actctctccc ccggcaacac acaagtccag actgtacacc agaagatggt     2880

gtggtgtttc ttaaggctgg aagaagggct gttgcaaggg gagagggtca gcccgctgga     2940

aagcagacac tttggttgaa agctgtatga agtggcatgt gctgtgatca tttataatca     3000

taggaaagat ttagtaatta gctgttgatt ctcaaagcag ggacccatgg aagtttttaa     3060

caaaaggtgt ctccttccaa ctttgaatct gacaactcct agaaaaagat gacctttgct     3120

tgtgcatatt tataatagcg ttcgttatca caataaatgt attcaaataa tggtttttaa     3180

aatcttg                                                               3187


<210> 15
<211> 334
<212> PRT
<213> Mus musculus

<400> 15
Met Thr Ala Lys Met Glu Thr Thr Phe Tyr Asp Asp Ala Leu Asn Ala 
1               5                   10                  15      


Ser Phe Leu Gln Ser Glu Ser Gly Ala Tyr Gly Tyr Ser Asn Pro Lys 
            20                  25                  30          


Ile Leu Lys Gln Ser Met Thr Leu Asn Leu Ala Asp Pro Val Gly Ser 
        35                  40                  45              


Leu Lys Pro His Leu Arg Ala Lys Asn Ser Asp Leu Leu Thr Ser Pro 
    50                  55                  60                  


Asp Val Gly Leu Leu Lys Leu Ala Ser Pro Glu Leu Glu Arg Leu Ile 
65                  70                  75                  80  


Ile Gln Ser Ser Asn Gly His Ile Thr Thr Thr Pro Thr Pro Thr Gln 
                85                  90                  95      


Phe Leu Cys Pro Lys Asn Val Thr Asp Glu Gln Glu Gly Phe Ala Glu 
            100                 105                 110         


Gly Phe Val Arg Ala Leu Ala Glu Leu His Ser Gln Asn Thr Leu Pro 
        115                 120                 125             


Ser Val Thr Ser Ala Ala Gln Pro Val Ser Gly Ala Gly Met Val Ala 
    130                 135                 140                 


Pro Ala Val Ala Ser Val Ala Gly Ala Gly Gly Gly Gly Gly Tyr Ser 
145                 150                 155                 160 


Ala Ser Leu His Ser Glu Pro Pro Val Tyr Ala Asn Leu Ser Asn Phe 
                165                 170                 175     


Asn Pro Gly Ala Leu Ser Ser Gly Gly Gly Ala Pro Ser Tyr Gly Ala 
            180                 185                 190         


Ala Gly Leu Ala Phe Pro Ser Gln Pro Gln Gln Gln Gln Gln Pro Pro 
        195                 200                 205             


Gln Pro Pro His His Leu Pro Gln Gln Ile Pro Val Gln His Pro Arg 
    210                 215                 220                 


Leu Gln Ala Leu Lys Glu Glu Pro Gln Thr Val Pro Glu Met Pro Gly 
225                 230                 235                 240 


Glu Thr Pro Pro Leu Ser Pro Ile Asp Met Glu Ser Gln Glu Arg Ile 
                245                 250                 255     


Lys Ala Glu Arg Lys Arg Met Arg Asn Arg Ile Ala Ala Ser Lys Cys 
            260                 265                 270         


Arg Lys Arg Lys Leu Glu Arg Ile Ala Arg Leu Glu Glu Lys Val Lys 
        275                 280                 285             


Thr Leu Lys Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu 
    290                 295                 300                 


Arg Glu Gln Val Ala Gln Leu Lys Gln Lys Val Met Asn His Val Asn 
305                 310                 315                 320 


Ser Gly Cys Gln Leu Met Leu Thr Gln Gln Leu Gln Thr Phe 
                325                 330                 


<210> 16
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
aacagatccg agcagcttct a                                                 21


<210> 17
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
ttttgagctt caaccggcat c                                                 21


<210> 18
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 18
gtcccctgtc tgatttgtag gaa                                               23


<210> 19
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
ccacaccatc ttctggtgta cagt                                              24


<210> 20
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
gcccatcctc tgtgactcat g                                                 21


<210> 21
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
ggagcctgta gtgcagctgt ct                                                22


<210> 22
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
tggagtcaca gaaggagtgg ctaag                                             25


<210> 23
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
tctgaccaca gtgaggaatg tccac                                             25


<210> 24
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
gagccactag ccatcctgg                                                    19


<210> 25
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
ctgagcaaga tccatgcttg g                                                 21


<210> 26
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
gagcccaatc acgtttcagt tt                                                22


<210> 27
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 27
tccttcctgc ttcttgctag ct                                                22


<210> 28
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 28
tcatggtctt cggaggattc ac                                                22


<210> 29
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
tcacctccaa gtgtggcaaa g                                                 21


<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 30
gttgagcgtc aagacccagt                                                   20


<210> 31
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 31
gggtggcaaa gaaaaggag                                                    19


<210> 32
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 32
tccagtagaa tccgctctcc t                                                 21


<210> 33
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 33
gccacaagca ggaatgagaa g                                                 21


<210> 34
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 34
accatgcacc gatacacgc                                                    19


<210> 35
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 35
agccacgagc ttcctgact                                                    19


<210> 36
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 36
gaagtcctcc ctcctttaaa tgtg                                              24


<210> 37
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 37
tgggagttga atgaagcagt gt                                                22


<210> 38
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 38
aacgatgaag ccctggagtg                                                   20


<210> 39
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 39
tgagaggtct ggttcccga                                                    19


<210> 40
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 40
aacgatgaag ccctggagtg                                                   20


<210> 41
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 41
gacaaacaaa tgctttctcc g                                                 21


<210> 42
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 42
aacgatgaag ccctggagtg                                                   20


<210> 43
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 43
aacaaggctc acagtgaacg                                                   20


<210> 44
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 44
ggagatcctt cgaggagcac tt                                                22


<210> 45
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 45
ggcgatttag cagcagatat aagaa                                             25


<210> 46
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 46
tctcttgctc ttagtgatgg                                                   20


<210> 47
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 47
cttacaactg atattgctgg g                                                 21


<210> 48
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 48
acctggtgct ggattgtatc ta                                                22


<210> 49
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 49
ggaccttacc tgttcgtgaa ac                                                22


<210> 50
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 50
ggtagttagt agagcatgtg ag                                                22


<210> 51
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 51
aacctcacca aagccagcac at                                                22


<210> 52
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 52
aggaccttgt gtgatcagac ca                                                22


<210> 53
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 53
gatttaagac aagcgtataa ca                                                22


<210> 54
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 54
gctctggacg tttactgatt ga                                                22


