                         SEQUENCE LISTING

<110>  FMC Corporation
 
<120>  CELLULOSE SYNTHASE INHIBITORS EFFECTIVE AS HERBICIDES

<130>  61313-WO

<150>  62/4246558
<151>  2016-11-21

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  3246
<212>  DNA
<213>  ARABIDOPSIS THALIANA

<400>  1
atggaggcca gtgccggctt ggttgctgga tcctaccgga gaaacgagct cgttcggatc       60

cgacatgaat ctgatggcgg gaccaaacct ttgaagaata tgaatggcca gatatgtcag      120

atctgtggtg atgatgttgg actcgctgaa actggagatg tctttgtcgc gtgtaatgaa      180

tgtgccttcc ctgtgtgtcg gccttgctat gagtacgaga ggaaagatgg aactcagtgt      240

tgccctcaat gcaagactag attcagacga cacaggggga gtcctcgtgt tgaaggagat      300

gaagatgagg atgatgttga tgatatcgag aatgagttca attacgccca gggagctaac      360

aaggcgagac accaacgcca tggcgaagag ttttcttctt cctctagaca tgaatctcaa      420

ccaattcctc ttctcaccca tggccatacg gtttctggag agattcgcac gcctgataca      480

caatctgtgc gaactacatc aggtcctttg ggtccttctg acaggaatgc tatttcatct      540

ccatatattg atccacggca acctgtccct gtaagaatcg tggacccgtc aaaagacttg      600

aactcttatg ggcttggtaa tgttgactgg aaagaaagag ttgaaggctg gaagctgaag      660

caggagaaaa atatgttaca gatgactggt aaataccatg aagggaaagg aggagaaatt      720

gaagggactg gttccaatgg cgaagaactc caaatggctg atgatacacg tcttcctatg      780

agtcgtgtgg tgcctatccc atcttctcgc ctaacccctt atcgggttgt gattattctc      840

cggcttatca tcttgtgttt cttcttgcaa tatcgtacaa ctcaccctgt gaaaaatgca      900

tatcctttgt ggttgacctc ggttatctgt gagatctggt ttgcattttc ttggcttctt      960

gatcagtttc ccaaatggta ccccattaac agggagactt atcttgaccg tctcgctata     1020

agatatgatc gagacggtga accatcacag ctcgttcctg ttgatgtgtt tgttagtaca     1080

gtggacccat tgaaagagcc tccccttgtt acagcaaaca cagttctctc gattctttct     1140

gtggactacc cggtagataa agtagcctgt tatgtttcag atgatggttc agctatgctt     1200

acctttgaat ccctttctga aaccgctgag tttgcaaaga aatgggtacc attttgcaag     1260

aaattcaaca ttgaacctag ggcccctgaa ttctattttg cccagaagat agattacttg     1320

aaggacaaga tccaaccgtc ttttgttaaa gagcgacgag ctatgaagag agagtatgaa     1380

gagtttaaag tgaggataaa tgctcttgtt gccaaagcac agaaaatccc tgaagaaggc     1440

tggacaatgc aggatggtac tccctggcct ggtaacaaca ctagagatca tcctggaatg     1500

atacaggtgt tcttaggcca tagtgggggt ctggataccg atggaaatga gctgcctaga     1560

ctcatctatg tttctcgtga aaagcggcct ggatttcaac accacaaaaa ggctggagct     1620

atgaatgcat tgatccgtgt atctgctgtt cttaccaatg gagcatatct tttgaacgtg     1680

gattgtgatc attactttaa taacagtaag gctattaaag aagctatgtg tttcatgatg     1740

gacccggcta ttggaaagaa gtgctgctat gtccagttcc ctcaacgttt tgacggtatt     1800

gatttgcacg atcgatatgc caacaggaat atagtctttt tcgatattaa catgaagggg     1860

ttggatggta tccagggtcc agtatatgtg ggtactggtt gttgttttaa taggcaggct     1920

ctatatgggt atgatcctgt tttgacggaa gaagatttag aaccaaatat tattgtcaag     1980

agctgttgcg ggtcaaggaa gaaaggtaaa agtagcaaga agtataacta cgaaaagagg     2040

agaggcatca acagaagtga ctccaatgct ccacttttca atatggagga catcgatgag     2100

ggttttgaag gttatgatga tgagaggtct attctaatgt cccagaggag tgtagagaag     2160

cgttttggtc agtcgccggt atttattgcg gcaaccttca tggaacaagg cggcattcca     2220

ccaacaacca atcccgctac tcttctgaag gaggctattc atgttataag ctgtggttac     2280

gaagacaaga ctgaatgggg caaagagatt ggttggatct atggttccgt gacggaagat     2340

attcttactg ggttcaagat gcatgcccgg ggttggatat cgatctactg caatcctcca     2400

cgccctgcgt tcaagggatc tgcaccaatc aatctttctg atcgtttgaa ccaagttctt     2460

cgatgggctt tgggatctat cgagattctt cttagcagac attgtcctat ctggtatggt     2520

taccatggaa ggttgagact tttggagagg atcgcttata tcaacaccat cgtctatcct     2580

attacatcca tccctcttat tgcgtattgt attcttcccg ctttttgtct catcaccgac     2640

agattcatca tacccgagat aagcaactac gcgagtattt ggttcattct actcttcatc     2700

tcaattgctg tgactggaat cctggagctg agatggagcg gtgtgagcat tgaggattgg     2760

tggaggaacg agcagttctg ggtcattggt ggcacatccg cccatctttt tgctgtcttc     2820

caaggtctac ttaaggttct tgctggtatc gacaccaact tcaccgttac atctaaagcc     2880

acagacgaag atggggattt tgcagaactc tacatcttca aatggacagc tcttctcatt     2940

ccaccaacca ccgtcctact tgtgaacctc ataggcattg tggctggtgt ctcttatgct     3000

gtaaacagtg gctaccagtc gtggggtccg cttttcggga agctcttctt cgccttatgg     3060

gttattgccc atctctaccc tttcttgaaa ggtctgttgg gaagacaaaa ccgaacacca     3120

accatcgtca ttgtctggtc tgttcttctc gcctccatct tctcgttgct ttgggtcagg     3180

atcaatccct ttgtggacgc caatcccaat gccaacaact tcaatggcaa aggaggtgtc     3240

ttttag                                                                3246


<210>  2
<211>  1081
<212>  PRT
<213>  ARABIDOPSIS THALIANA

<400>  2

Met Glu Ala Ser Ala Gly Leu Val Ala Gly Ser Tyr Arg Arg Asn Glu 
1               5                   10                  15      


Leu Val Arg Ile Arg His Glu Ser Asp Gly Gly Thr Lys Pro Leu Lys 
            20                  25                  30          


Asn Met Asn Gly Gln Ile Cys Gln Ile Cys Gly Asp Asp Val Gly Leu 
        35                  40                  45              


Ala Glu Thr Gly Asp Val Phe Val Ala Cys Asn Glu Cys Ala Phe Pro 
    50                  55                  60                  


Val Cys Arg Pro Cys Tyr Glu Tyr Glu Arg Lys Asp Gly Thr Gln Cys 
65                  70                  75                  80  


Cys Pro Gln Cys Lys Thr Arg Phe Arg Arg His Arg Gly Ser Pro Arg 
                85                  90                  95      


Val Glu Gly Asp Glu Asp Glu Asp Asp Val Asp Asp Ile Glu Asn Glu 
            100                 105                 110         


Phe Asn Tyr Ala Gln Gly Ala Asn Lys Ala Arg His Gln Arg His Gly 
        115                 120                 125             


Glu Glu Phe Ser Ser Ser Ser Arg His Glu Ser Gln Pro Ile Pro Leu 
    130                 135                 140                 


Leu Thr His Gly His Thr Val Ser Gly Glu Ile Arg Thr Pro Asp Thr 
145                 150                 155                 160 


Gln Ser Val Arg Thr Thr Ser Gly Pro Leu Gly Pro Ser Asp Arg Asn 
                165                 170                 175     


Ala Ile Ser Ser Pro Tyr Ile Asp Pro Arg Gln Pro Val Pro Val Arg 
            180                 185                 190         


Ile Val Asp Pro Ser Lys Asp Leu Asn Ser Tyr Gly Leu Gly Asn Val 
        195                 200                 205             


Asp Trp Lys Glu Arg Val Glu Gly Trp Lys Leu Lys Gln Glu Lys Asn 
    210                 215                 220                 


Met Leu Gln Met Thr Gly Lys Tyr His Glu Gly Lys Gly Gly Glu Ile 
225                 230                 235                 240 


Glu Gly Thr Gly Ser Asn Gly Glu Glu Leu Gln Met Ala Asp Asp Thr 
                245                 250                 255     


Arg Leu Pro Met Ser Arg Val Val Pro Ile Pro Ser Ser Arg Leu Thr 
            260                 265                 270         


Pro Tyr Arg Val Val Ile Ile Leu Arg Leu Ile Ile Leu Cys Phe Phe 
        275                 280                 285             


Leu Gln Tyr Arg Thr Thr His Pro Val Lys Asn Ala Tyr Pro Leu Trp 
    290                 295                 300                 


Leu Thr Ser Val Ile Cys Glu Ile Trp Phe Ala Phe Ser Trp Leu Leu 
305                 310                 315                 320 


Asp Gln Phe Pro Lys Trp Tyr Pro Ile Asn Arg Glu Thr Tyr Leu Asp 
                325                 330                 335     


Arg Leu Ala Ile Arg Tyr Asp Arg Asp Gly Glu Pro Ser Gln Leu Val 
            340                 345                 350         


Pro Val Asp Val Phe Val Ser Thr Val Asp Pro Leu Lys Glu Pro Pro 
        355                 360                 365             


Leu Val Thr Ala Asn Thr Val Leu Ser Ile Leu Ser Val Asp Tyr Pro 
    370                 375                 380                 


Val Asp Lys Val Ala Cys Tyr Val Ser Asp Asp Gly Ser Ala Met Leu 
385                 390                 395                 400 


Thr Phe Glu Ser Leu Ser Glu Thr Ala Glu Phe Ala Lys Lys Trp Val 
                405                 410                 415     


Pro Phe Cys Lys Lys Phe Asn Ile Glu Pro Arg Ala Pro Glu Phe Tyr 
            420                 425                 430         


Phe Ala Gln Lys Ile Asp Tyr Leu Lys Asp Lys Ile Gln Pro Ser Phe 
        435                 440                 445             


Val Lys Glu Arg Arg Ala Met Lys Arg Glu Tyr Glu Glu Phe Lys Val 
    450                 455                 460                 


Arg Ile Asn Ala Leu Val Ala Lys Ala Gln Lys Ile Pro Glu Glu Gly 
465                 470                 475                 480 


Trp Thr Met Gln Asp Gly Thr Pro Trp Pro Gly Asn Asn Thr Arg Asp 
                485                 490                 495     


His Pro Gly Met Ile Gln Val Phe Leu Gly His Ser Gly Gly Leu Asp 
            500                 505                 510         


Thr Asp Gly Asn Glu Leu Pro Arg Leu Ile Tyr Val Ser Arg Glu Lys 
        515                 520                 525             


Arg Pro Gly Phe Gln His His Lys Lys Ala Gly Ala Met Asn Ala Leu 
    530                 535                 540                 


Ile Arg Val Ser Ala Val Leu Thr Asn Gly Ala Tyr Leu Leu Asn Val 
545                 550                 555                 560 


Asp Cys Asp His Tyr Phe Asn Asn Ser Lys Ala Ile Lys Glu Ala Met 
                565                 570                 575     


Cys Phe Met Met Asp Pro Ala Ile Gly Lys Lys Cys Cys Tyr Val Gln 
            580                 585                 590         


Phe Pro Gln Arg Phe Asp Gly Ile Asp Leu His Asp Arg Tyr Ala Asn 
        595                 600                 605             


Arg Asn Ile Val Phe Phe Asp Ile Asn Met Lys Gly Leu Asp Gly Ile 
    610                 615                 620                 


Gln Gly Pro Val Tyr Val Gly Thr Gly Cys Cys Phe Asn Arg Gln Ala 
625                 630                 635                 640 


Leu Tyr Gly Tyr Asp Pro Val Leu Thr Glu Glu Asp Leu Glu Pro Asn 
                645                 650                 655     


Ile Ile Val Lys Ser Cys Cys Gly Ser Arg Lys Lys Gly Lys Ser Ser 
            660                 665                 670         


Lys Lys Tyr Asn Tyr Glu Lys Arg Arg Gly Ile Asn Arg Ser Asp Ser 
        675                 680                 685             


Asn Ala Pro Leu Phe Asn Met Glu Asp Ile Asp Glu Gly Phe Glu Gly 
    690                 695                 700                 


Tyr Asp Asp Glu Arg Ser Ile Leu Met Ser Gln Arg Ser Val Glu Lys 
705                 710                 715                 720 


Arg Phe Gly Gln Ser Pro Val Phe Ile Ala Ala Thr Phe Met Glu Gln 
                725                 730                 735     


Gly Gly Ile Pro Pro Thr Thr Asn Pro Ala Thr Leu Leu Lys Glu Ala 
            740                 745                 750         


Ile His Val Ile Ser Cys Gly Tyr Glu Asp Lys Thr Glu Trp Gly Lys 
        755                 760                 765             


Glu Ile Gly Trp Ile Tyr Gly Ser Val Thr Glu Asp Ile Leu Thr Gly 
    770                 775                 780                 


Phe Lys Met His Ala Arg Gly Trp Ile Ser Ile Tyr Cys Asn Pro Pro 
785                 790                 795                 800 


Arg Pro Ala Phe Lys Gly Ser Ala Pro Ile Asn Leu Ser Asp Arg Leu 
                805                 810                 815     


Asn Gln Val Leu Arg Trp Ala Leu Gly Ser Ile Glu Ile Leu Leu Ser 
            820                 825                 830         


Arg His Cys Pro Ile Trp Tyr Gly Tyr His Gly Arg Leu Arg Leu Leu 
        835                 840                 845             


Glu Arg Ile Ala Tyr Ile Asn Thr Ile Val Tyr Pro Ile Thr Ser Ile 
    850                 855                 860                 


Pro Leu Ile Ala Tyr Cys Ile Leu Pro Ala Phe Cys Leu Ile Thr Asp 
865                 870                 875                 880 


Arg Phe Ile Ile Pro Glu Ile Ser Asn Tyr Ala Ser Ile Trp Phe Ile 
                885                 890                 895     


Leu Leu Phe Ile Ser Ile Ala Val Thr Gly Ile Leu Glu Leu Arg Trp 
            900                 905                 910         


Ser Gly Val Ser Ile Glu Asp Trp Trp Arg Asn Glu Gln Phe Trp Val 
        915                 920                 925             


Ile Gly Gly Thr Ser Ala His Leu Phe Ala Val Phe Gln Gly Leu Leu 
    930                 935                 940                 


Lys Val Leu Ala Gly Ile Asp Thr Asn Phe Thr Val Thr Ser Lys Ala 
945                 950                 955                 960 


Thr Asp Glu Asp Gly Asp Phe Ala Glu Leu Tyr Ile Phe Lys Trp Thr 
                965                 970                 975     


Ala Leu Leu Ile Pro Pro Thr Thr Val Leu Leu Val Asn Leu Ile Gly 
            980                 985                 990         


Ile Val Ala Gly Val Ser Tyr Ala  Val Asn Ser Gly Tyr  Gln Ser Trp 
        995                 1000                 1005             


Gly Pro  Leu Phe Gly Lys Leu  Phe Phe Ala Leu Trp  Val Ile Ala 
    1010                 1015                 1020             


His Leu  Tyr Pro Phe Leu Lys  Gly Leu Leu Gly Arg  Gln Asn Arg 
    1025                 1030                 1035             


Thr Pro  Thr Ile Val Ile Val  Trp Ser Val Leu Leu  Ala Ser Ile 
    1040                 1045                 1050             


Phe Ser  Leu Leu Trp Val Arg  Ile Asn Pro Phe Val  Asp Ala Asn 
    1055                 1060                 1065             


Pro Asn  Ala Asn Asn Phe Asn  Gly Lys Gly Gly Val  Phe 
    1070                 1075                 1080     


<210>  3
<211>  3246
<212>  DNA
<213>  ARABIDOPSIS THALIANA

<400>  3
atggaggcca gtgccggctt ggttgctgga tcctaccgga gaaacgagct cgttcggatc       60

cgacatgaat ctgatggcgg gaccaaacct ttgaagaata tgaatggcca gatatgtcag      120

atctgtggtg atgatgttgg actcgctgaa actggagatg tctttgtcgc gtgtaatgaa      180

tgtgccttcc ctgtgtgtcg gccttgctat gagtacgaga ggaaagatgg aactcagtgt      240

tgccctcaat gcaagactag attcagacga cacaggggga gtcctcgtgt tgaaggagat      300

gaagatgagg atgatgttga tgatatcgag aatgagttca attacgccca gggagctaac      360

aaggcgagac accaacgcca tggcgaagag ttttcttctt cctctagaca tgaatctcaa      420

ccaattcctc ttctcaccca tggccatacg gtttctggag agattcgcac gcctgataca      480

caatctgtgc gaactacatc aggtcctttg ggtccttctg acaggaatgc tatttcatct      540

ccatatattg atccacggca acctgtccct gtaagaatcg tggacccgtc aaaagacttg      600

aactcttatg ggcttggtaa tgttgactgg aaagaaagag ttgaaggctg gaagctgaag      660

caggagaaaa atatgttaca gatgactggt aaataccatg aagggaaagg aggagaaatt      720

gaagggactg gttccaatgg cgaagaactc caaatggctg atgatacacg tcttcctatg      780

agtcgtgtgg tgcctatccc atcttctcgc ctaacccctt atcgggttgt gattattctc      840

cggcttatca tcttgtgttt cttcttgcaa tatcgtacaa ctcaccctgt gaaaaatgca      900

tatcctttgt ggttgacctc ggttatctgt gagatctggt ttgcattttc ttggcttctt      960

gatcagtttc ccaaatggta ccccattaac agggagactt atcttgaccg tctcgctata     1020

agatatgatc gagacggtga accatcacag ctcgttcctg ttgatgtgtt tgttagtaca     1080

gtggacccat tgaaagagcc tccccttgtt acagcaaaca cagttctctc gattctttct     1140

gtggactacc cggtagataa agtagcctgt tatgtttcag atgatggttc agctatgctt     1200

acctttgaat ccctttctga aaccgctgag tttgcaaaga aatgggtacc attttgcaag     1260

aaattcaaca ttgaacctag ggcccctgaa ttctattttg cccagaagat agattacttg     1320

aaggacaaga tccaaccgtc ttttgttaaa gagcgacgag ctatgaagag agagtatgaa     1380

gagtttaaag tgaggataaa tgctcttgtt gccaaagcac agaaaatccc tgaagaaggc     1440

tggacaatgc aggatggtac tccctggcct ggtaacaaca ctagagatca tcctggaatg     1500

atacaggtgt tcttaggcca tagtgggggt ctggataccg atggaaatga gctgcctaga     1560

ctcatctatg tttctcgtga aaagcggcct ggatttcaac accacaaaaa ggctggagct     1620

atgaatgcat tgatccgtgt atctgctgtt cttaccaatg gagcatatct tttgaacgtg     1680

gattgtgatc attactttaa taacagtaag gctattaaag aagctatgtg tttcatgatg     1740

gacccggcta ttggaaagaa gtgctgctat gtccagttcc ctcaacgttt tgacggtatt     1800

gatttgcacg atcgatatgc caacaggaat atagtctttt tcgatattaa catgaagggg     1860

ttggatggta tccagggtcc agtatatgtg ggtactggtt gttgttttaa taggcaggct     1920

ctatatgggt atgatcctgt tttgacggaa gaagatttag aaccaaatat tattgtcaag     1980

agctgttgcg ggtcaaggaa gaaaggtaaa agtagcaaga agtataacta cgaaaagagg     2040

agaggcatca acagaagtga ctccaatgct ccacttttca atatggagga catcgatgag     2100

ggttttgaag gttatgatga tgagaggtct attctaatgt cccagaggag tgtagagaag     2160

cgttttggtc agtcgccggt atttattgcg gcaaccttca tggaacaagg cggcattcca     2220

ccaacaacca atcccgctac tcttctgaag gaggctattc atgttataag ctgtggttac     2280

gaagacaaga ctgaatgggg caaagagatt ggttggatct atggttccgt gacggaagat     2340

attcttactg ggttcaagat gcatgcccgg ggttggatat cgatctactg caatcctcca     2400

cgccctgcgt tcaagggatc tgcaccaatc aatctttctg atcgtttgaa ccaagttctt     2460

cgatgggctt tgggatctat cgagattctt cttagcagac attgtcctat ctggtatggt     2520

taccatggaa ggttgagact tttggagagg atcgcttata tcaacaccat cgtctatcct     2580

attacatcca tccctcttat tgcgtattgt attcttcccg ctttttgtct catcaccgac     2640

agattcatca tacccgagat aagcaactac gcgagtattt ggttcattct actcttcatc     2700

tcaattgttg tgactggaat cctggagctg agatggagcg gtgtgagcat tgaggattgg     2760

tggaggaacg agcagttctg ggtcattggt ggcacatccg cccatctttt tgctgtcttc     2820

caaggtctac ttaaggttct tgctggtatc gacaccaact tcaccgttac atctaaagcc     2880

acagacgaag atggggattt tgcagaactc tacatcttca aatggacagc tcttctcatt     2940

ccaccaacca ccgtcctact tgtgaacctc ataggcattg tggctggtgt ctcttatgct     3000

gtaaacagtg gctaccagtc gtggggtccg cttttcggga agctcttctt cgccttatgg     3060

gttattgccc atctctaccc tttcttgaaa ggtctgttgg gaagacaaaa ccgaacacca     3120

accatcgtca ttgtctggtc tgttcttctc gcctccatct tctcgttgct ttgggtcagg     3180

atcaatccct ttgtggacgc caatcccaat gccaacaact tcaatggcaa aggaggtgtc     3240

ttttag                                                                3246


<210>  4
<211>  1081
<212>  PRT
<213>  ARABIDOPSIS THALIANA

<400>  4

Met Glu Ala Ser Ala Gly Leu Val Ala Gly Ser Tyr Arg Arg Asn Glu 
1               5                   10                  15      


Leu Val Arg Ile Arg His Glu Ser Asp Gly Gly Thr Lys Pro Leu Lys 
            20                  25                  30          


Asn Met Asn Gly Gln Ile Cys Gln Ile Cys Gly Asp Asp Val Gly Leu 
        35                  40                  45              


Ala Glu Thr Gly Asp Val Phe Val Ala Cys Asn Glu Cys Ala Phe Pro 
    50                  55                  60                  


Val Cys Arg Pro Cys Tyr Glu Tyr Glu Arg Lys Asp Gly Thr Gln Cys 
65                  70                  75                  80  


Cys Pro Gln Cys Lys Thr Arg Phe Arg Arg His Arg Gly Ser Pro Arg 
                85                  90                  95      


Val Glu Gly Asp Glu Asp Glu Asp Asp Val Asp Asp Ile Glu Asn Glu 
            100                 105                 110         


Phe Asn Tyr Ala Gln Gly Ala Asn Lys Ala Arg His Gln Arg His Gly 
        115                 120                 125             


Glu Glu Phe Ser Ser Ser Ser Arg His Glu Ser Gln Pro Ile Pro Leu 
    130                 135                 140                 


Leu Thr His Gly His Thr Val Ser Gly Glu Ile Arg Thr Pro Asp Thr 
145                 150                 155                 160 


Gln Ser Val Arg Thr Thr Ser Gly Pro Leu Gly Pro Ser Asp Arg Asn 
                165                 170                 175     


Ala Ile Ser Ser Pro Tyr Ile Asp Pro Arg Gln Pro Val Pro Val Arg 
            180                 185                 190         


Ile Val Asp Pro Ser Lys Asp Leu Asn Ser Tyr Gly Leu Gly Asn Val 
        195                 200                 205             


Asp Trp Lys Glu Arg Val Glu Gly Trp Lys Leu Lys Gln Glu Lys Asn 
    210                 215                 220                 


Met Leu Gln Met Thr Gly Lys Tyr His Glu Gly Lys Gly Gly Glu Ile 
225                 230                 235                 240 


Glu Gly Thr Gly Ser Asn Gly Glu Glu Leu Gln Met Ala Asp Asp Thr 
                245                 250                 255     


Arg Leu Pro Met Ser Arg Val Val Pro Ile Pro Ser Ser Arg Leu Thr 
            260                 265                 270         


Pro Tyr Arg Val Val Ile Ile Leu Arg Leu Ile Ile Leu Cys Phe Phe 
        275                 280                 285             


Leu Gln Tyr Arg Thr Thr His Pro Val Lys Asn Ala Tyr Pro Leu Trp 
    290                 295                 300                 


Leu Thr Ser Val Ile Cys Glu Ile Trp Phe Ala Phe Ser Trp Leu Leu 
305                 310                 315                 320 


Asp Gln Phe Pro Lys Trp Tyr Pro Ile Asn Arg Glu Thr Tyr Leu Asp 
                325                 330                 335     


Arg Leu Ala Ile Arg Tyr Asp Arg Asp Gly Glu Pro Ser Gln Leu Val 
            340                 345                 350         


Pro Val Asp Val Phe Val Ser Thr Val Asp Pro Leu Lys Glu Pro Pro 
        355                 360                 365             


Leu Val Thr Ala Asn Thr Val Leu Ser Ile Leu Ser Val Asp Tyr Pro 
    370                 375                 380                 


Val Asp Lys Val Ala Cys Tyr Val Ser Asp Asp Gly Ser Ala Met Leu 
385                 390                 395                 400 


Thr Phe Glu Ser Leu Ser Glu Thr Ala Glu Phe Ala Lys Lys Trp Val 
                405                 410                 415     


Pro Phe Cys Lys Lys Phe Asn Ile Glu Pro Arg Ala Pro Glu Phe Tyr 
            420                 425                 430         


Phe Ala Gln Lys Ile Asp Tyr Leu Lys Asp Lys Ile Gln Pro Ser Phe 
        435                 440                 445             


Val Lys Glu Arg Arg Ala Met Lys Arg Glu Tyr Glu Glu Phe Lys Val 
    450                 455                 460                 


Arg Ile Asn Ala Leu Val Ala Lys Ala Gln Lys Ile Pro Glu Glu Gly 
465                 470                 475                 480 


Trp Thr Met Gln Asp Gly Thr Pro Trp Pro Gly Asn Asn Thr Arg Asp 
                485                 490                 495     


His Pro Gly Met Ile Gln Val Phe Leu Gly His Ser Gly Gly Leu Asp 
            500                 505                 510         


Thr Asp Gly Asn Glu Leu Pro Arg Leu Ile Tyr Val Ser Arg Glu Lys 
        515                 520                 525             


Arg Pro Gly Phe Gln His His Lys Lys Ala Gly Ala Met Asn Ala Leu 
    530                 535                 540                 


Ile Arg Val Ser Ala Val Leu Thr Asn Gly Ala Tyr Leu Leu Asn Val 
545                 550                 555                 560 


Asp Cys Asp His Tyr Phe Asn Asn Ser Lys Ala Ile Lys Glu Ala Met 
                565                 570                 575     


Cys Phe Met Met Asp Pro Ala Ile Gly Lys Lys Cys Cys Tyr Val Gln 
            580                 585                 590         


Phe Pro Gln Arg Phe Asp Gly Ile Asp Leu His Asp Arg Tyr Ala Asn 
        595                 600                 605             


Arg Asn Ile Val Phe Phe Asp Ile Asn Met Lys Gly Leu Asp Gly Ile 
    610                 615                 620                 


Gln Gly Pro Val Tyr Val Gly Thr Gly Cys Cys Phe Asn Arg Gln Ala 
625                 630                 635                 640 


Leu Tyr Gly Tyr Asp Pro Val Leu Thr Glu Glu Asp Leu Glu Pro Asn 
                645                 650                 655     


Ile Ile Val Lys Ser Cys Cys Gly Ser Arg Lys Lys Gly Lys Ser Ser 
            660                 665                 670         


Lys Lys Tyr Asn Tyr Glu Lys Arg Arg Gly Ile Asn Arg Ser Asp Ser 
        675                 680                 685             


Asn Ala Pro Leu Phe Asn Met Glu Asp Ile Asp Glu Gly Phe Glu Gly 
    690                 695                 700                 


Tyr Asp Asp Glu Arg Ser Ile Leu Met Ser Gln Arg Ser Val Glu Lys 
705                 710                 715                 720 


Arg Phe Gly Gln Ser Pro Val Phe Ile Ala Ala Thr Phe Met Glu Gln 
                725                 730                 735     


Gly Gly Ile Pro Pro Thr Thr Asn Pro Ala Thr Leu Leu Lys Glu Ala 
            740                 745                 750         


Ile His Val Ile Ser Cys Gly Tyr Glu Asp Lys Thr Glu Trp Gly Lys 
        755                 760                 765             


Glu Ile Gly Trp Ile Tyr Gly Ser Val Thr Glu Asp Ile Leu Thr Gly 
    770                 775                 780                 


Phe Lys Met His Ala Arg Gly Trp Ile Ser Ile Tyr Cys Asn Pro Pro 
785                 790                 795                 800 


Arg Pro Ala Phe Lys Gly Ser Ala Pro Ile Asn Leu Ser Asp Arg Leu 
                805                 810                 815     


Asn Gln Val Leu Arg Trp Ala Leu Gly Ser Ile Glu Ile Leu Leu Ser 
            820                 825                 830         


Arg His Cys Pro Ile Trp Tyr Gly Tyr His Gly Arg Leu Arg Leu Leu 
        835                 840                 845             


Glu Arg Ile Ala Tyr Ile Asn Thr Ile Val Tyr Pro Ile Thr Ser Ile 
    850                 855                 860                 


Pro Leu Ile Ala Tyr Cys Ile Leu Pro Ala Phe Cys Leu Ile Thr Asp 
865                 870                 875                 880 


Arg Phe Ile Ile Pro Glu Ile Ser Asn Tyr Ala Ser Ile Trp Phe Ile 
                885                 890                 895     


Leu Leu Phe Ile Ser Ile Val Val Thr Gly Ile Leu Glu Leu Arg Trp 
            900                 905                 910         


Ser Gly Val Ser Ile Glu Asp Trp Trp Arg Asn Glu Gln Phe Trp Val 
        915                 920                 925             


Ile Gly Gly Thr Ser Ala His Leu Phe Ala Val Phe Gln Gly Leu Leu 
    930                 935                 940                 


Lys Val Leu Ala Gly Ile Asp Thr Asn Phe Thr Val Thr Ser Lys Ala 
945                 950                 955                 960 


Thr Asp Glu Asp Gly Asp Phe Ala Glu Leu Tyr Ile Phe Lys Trp Thr 
                965                 970                 975     


Ala Leu Leu Ile Pro Pro Thr Thr Val Leu Leu Val Asn Leu Ile Gly 
            980                 985                 990         


Ile Val Ala Gly Val Ser Tyr Ala  Val Asn Ser Gly Tyr  Gln Ser Trp 
        995                 1000                 1005             


Gly Pro  Leu Phe Gly Lys Leu  Phe Phe Ala Leu Trp  Val Ile Ala 
    1010                 1015                 1020             


His Leu  Tyr Pro Phe Leu Lys  Gly Leu Leu Gly Arg  Gln Asn Arg 
    1025                 1030                 1035             


Thr Pro  Thr Ile Val Ile Val  Trp Ser Val Leu Leu  Ala Ser Ile 
    1040                 1045                 1050             


Phe Ser  Leu Leu Trp Val Arg  Ile Asn Pro Phe Val  Asp Ala Asn 
    1055                 1060                 1065             


Pro Asn  Ala Asn Asn Phe Asn  Gly Lys Gly Gly Val  Phe 
    1070                 1075                 1080     


