               SEQUENCE LISTING

<110> cureab GmbH

<120> ANTI-GP73 ANTIBODIES AND IMMUNOCONJUGATES

<130> Z2254 PCT BS

<150> EP16 19 9882.8
<151> 2016-11-21

<160> 44

<170> BiSSAP 1.3.6

<210> 1
<211> 401
<212> PRT
<213> Homo sapiens


<220> 
<223> GP73 UniProtKB Q8NBJ4

<400> 1
Met Met Gly Leu Gly Asn Gly Arg Arg Ser Met Lys Ser Pro Pro Leu 
1               5                   10                  15      
Val Leu Ala Ala Leu Val Ala Cys Ile Ile Val Leu Gly Phe Asn Tyr 
            20                  25                  30          
Trp Ile Ala Ser Ser Arg Ser Val Asp Leu Gln Thr Arg Ile Met Glu 
        35                  40                  45              
Leu Glu Gly Arg Val Arg Arg Ala Ala Ala Glu Arg Gly Ala Val Glu 
    50                  55                  60                  
Leu Lys Lys Asn Glu Phe Gln Gly Glu Leu Glu Lys Gln Arg Glu Gln 
65                  70                  75                  80  
Leu Asp Lys Ile Gln Ser Ser His Asn Phe Gln Leu Glu Ser Val Asn 
                85                  90                  95      
Lys Leu Tyr Gln Asp Glu Lys Ala Val Leu Val Asn Asn Ile Thr Thr 
            100                 105                 110         
Gly Glu Arg Leu Ile Arg Val Leu Gln Asp Gln Leu Lys Thr Leu Gln 
        115                 120                 125             
Arg Asn Tyr Gly Arg Leu Gln Gln Asp Val Leu Gln Phe Gln Lys Asn 
    130                 135                 140                 
Gln Thr Asn Leu Glu Arg Lys Phe Ser Tyr Asp Leu Ser Gln Cys Ile 
145                 150                 155                 160 
Asn Gln Met Lys Glu Val Lys Glu Gln Cys Glu Glu Arg Ile Glu Glu 
                165                 170                 175     
Val Thr Lys Lys Gly Asn Glu Ala Val Ala Ser Arg Asp Leu Ser Glu 
            180                 185                 190         
Asn Asn Asp Gln Arg Gln Gln Leu Gln Ala Leu Ser Glu Pro Gln Pro 
        195                 200                 205             
Arg Leu Gln Ala Ala Gly Leu Pro His Thr Glu Val Pro Gln Gly Lys 
    210                 215                 220                 
Gly Asn Val Leu Gly Asn Ser Lys Ser Gln Thr Pro Ala Pro Ser Ser 
225                 230                 235                 240 
Glu Val Val Leu Asp Ser Lys Arg Gln Val Glu Lys Glu Glu Thr Asn 
                245                 250                 255     
Glu Ile Gln Val Val Asn Glu Glu Pro Gln Arg Asp Arg Leu Pro Gln 
            260                 265                 270         
Glu Pro Gly Arg Glu Gln Val Val Glu Asp Arg Pro Val Gly Gly Arg 
        275                 280                 285             
Gly Phe Gly Gly Ala Gly Glu Leu Gly Gln Thr Pro Gln Val Gln Ala 
    290                 295                 300                 
Ala Leu Ser Val Ser Gln Glu Asn Pro Glu Met Glu Gly Pro Glu Arg 
305                 310                 315                 320 
Asp Gln Leu Val Ile Pro Asp Gly Gln Glu Glu Glu Gln Glu Ala Ala 
                325                 330                 335     
Gly Glu Gly Arg Asn Gln Gln Lys Leu Arg Gly Glu Asp Asp Tyr Asn 
            340                 345                 350         
Met Asp Glu Asn Glu Ala Glu Ser Glu Thr Asp Lys Gln Ala Ala Leu 
        355                 360                 365             
Ala Gly Asn Asp Arg Asn Ile Asp Val Phe Asn Val Glu Asp Gln Lys 
    370                 375                 380                 
Arg Asp Thr Ile Asn Leu Leu Asp Gln Arg Glu Lys Arg Asn His Thr 
385                 390                 395                 400 
Leu 
    

<210> 2
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-2 heavy chain variable region (VH)

<400> 2
Glu Val Gln Leu Leu Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Gly Ser Ala Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 3
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-2 light chain variable region (VL)

<400> 3
Asp Ile Gln Met Thr Gln Pro Ser Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      
Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Asp Ile Ser Val Gly Phe 
            20                  25                  30          
His Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              
Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  
Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Ile 
65                  70                  75                  80  
Leu Leu Ile Ser Gly Leu Gln Ser Asp Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      
Val Ile Trp His Thr Ser Gly Val Val Phe Gly Gly Gly Thr Lys Val 
            100                 105                 110         
Glu Ile Lys 
        115 

<210> 4
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-2 HVR-H1

<400> 4
Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               

<210> 5
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-2 HVR-H2

<400> 5
Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               

<210> 6
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-2 HVR-H3

<400> 6
Ala Arg Glu Gly Ser Ala Gly Met Asp Val 
1               5                   10  

<210> 7
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-2 HVR-L1

<400> 7
Ser Asp Ile Ser Val Gly Phe His Arg 
1               5                   

<210> 8
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-2 HVR-L2

<400> 8
Tyr Lys Ser Asp Ser Asp Lys 
1               5           

<210> 9
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-2 HVR-L3

<400> 9
Val Ile Trp His Thr Ser Gly Val Val 
1               5                   

<210> 10
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-1 heavy chain variable region (VH)

<400> 10
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Ser Tyr Asp Gly Ser Asn Lys Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Arg Ser Tyr Tyr Asp Ser Ser Gly Tyr Leu Phe Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 11
<211> 110
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-1 light chain variable region (VL)

<400> 11
Asp Ile Gln Met Thr Gln Pro His Ser Val Ser Glu Ser Val Gly Lys 
1               5                   10                  15      
Thr Val Ile Ile Thr Cys Thr Gly Gly Gly Gly Ser Ile Asp Thr Asn 
            20                  25                  30          
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Val Thr Leu 
        35                  40                  45              
Ile Tyr Glu Asp Asp Gln Arg Pro Phe Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Ala Ala Ile Asp Thr Ser Ser Ser Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  
Leu Thr Ala Glu Asp Glu Ala Thr Tyr Tyr Cys Gln Ser Ser His Ser 
                85                  90                  95      
Thr Ala Val Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110 

<210> 12
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-1 HVR-H1

<400> 12
Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               

<210> 13
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-1 HVR-H2

<400> 13
Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               

<210> 14
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-1 HVR-H3

<400> 14
Ala Arg Gly Arg Ser Tyr Tyr Asp Ser Ser Gly Tyr Leu Phe Asp Tyr 
1               5                   10                  15      



<210> 15
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-1 HVR-L1

<400> 15
Gly Gly Ser Ile Asp Thr Asn Tyr 
1               5               

<210> 16
<211> 3
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-1 HVR-L2

<400> 16
Glu Asp Asp 
1           

<210> 17
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-1 HVR-L3

<400> 17
Gln Ser Ser His Ser Thr Ala Val 
1               5               

<210> 18
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-4 heavy chain variable region (VH)

<400> 18
Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              
Gly Phe Ile Arg Asn Lys Ala Lys Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Ser Ile 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      
Tyr Cys Ala Arg Asp Pro Ser Thr Asn Tyr Trp Tyr Phe Asp Val Trp 
            100                 105                 110         
Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         

<210> 19
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-4 light chain variable region (VL)

<400> 19
Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          
Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      
Ser Tyr Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
Arg 
    

<210> 20
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-4 HVR-H1

<400> 20
Gly Phe Thr Phe Thr Asp Tyr 
1               5           

<210> 21
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-4 HVR-H2

<400> 21
Arg Asn Lys Ala Lys Gly Tyr Thr 
1               5               

<210> 22
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-4 HVR-H3

<400> 22
Asp Pro Ser Thr Asn Tyr Trp Tyr Phe Asp Val 
1               5                   10      

<210> 23
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-4 HVR-L1

<400> 23
Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      
Ala 
    

<210> 24
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-4 HVR-L2

<400> 24
Trp Ala Ser Thr Arg Glu Ser 
1               5           

<210> 25
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-4 HVR-L3

<400> 25
Lys Gln Ser Tyr Asn Leu Tyr Thr 
1               5               

<210> 26
<211> 330
<212> PRT
<213> Homo sapiens


<220> 
<223> G2-2/G2-1 heavy chain constant region (IgG1)

<400> 26
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210> 27
<211> 107
<212> PRT
<213> Homo sapiens


<220> 
<223> G2-2/G2-1 light chain constant region (kappa)

<400> 27
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         

<210> 28
<211> 330
<212> PRT
<213> Mus musculus


<220> 
<223> mG2-2/mG2-1 heavy chain constant region (IgG2a)

<400> 28
Ala Ser Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly 
1               5                   10                  15      
Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
    50                  55                  60                  
Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile 
65                  70                  75                  80  
Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
                85                  90                  95      
Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
            100                 105                 110         
Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
        115                 120                 125             
Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
145                 150                 155                 160 
Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
                165                 170                 175     
Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
            180                 185                 190         
His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
        195                 200                 205             
Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
    210                 215                 220                 
Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
225                 230                 235                 240 
Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
                245                 250                 255     
Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
            260                 265                 270         
Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
        275                 280                 285             
Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
    290                 295                 300                 
Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
305                 310                 315                 320 
Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                325                 330 

<210> 29
<211> 393
<212> PRT
<213> Mus musculus


<220> 
<223> GP73 UniProt Q91XA2

<400> 29
Met Met Gly Leu Gly Asn Gly Arg Arg Ser Met Lys Ser Pro Pro Leu 
1               5                   10                  15      
Ile Leu Ala Ala Leu Val Ala Cys Val Ile Val Leu Gly Phe Asn Tyr 
            20                  25                  30          
Trp Ile Ala Ser Ser Arg Ser Val Glu Leu Gln Thr Arg Ile Val Glu 
        35                  40                  45              
Leu Glu Gly Arg Val Arg Arg Ala Ala Ala Glu Arg Gly Ala Val Glu 
    50                  55                  60                  
Leu Lys Lys Asn Glu Phe Gln Gly Glu Leu Gln Lys Gln Arg Glu Gln 
65                  70                  75                  80  
Leu Asp Arg Ile Gln Ser Ser His Ser Phe Gln Leu Glu Asn Val Asn 
                85                  90                  95      
Lys Leu His Gln Asp Glu Lys Ala Val Leu Val Asn Asn Ile Thr Thr 
            100                 105                 110         
Gly Glu Lys Leu Ile Arg Asp Leu Gln Asp Gln Leu Lys Ala Leu Gln 
        115                 120                 125             
Arg Ser Tyr Ser Ser Leu Gln Gln Asp Ile Phe Gln Phe Gln Lys Asn 
    130                 135                 140                 
Gln Thr Ser Leu Glu Lys Lys Phe Ser Tyr Asp Leu Asn Gln Cys Ile 
145                 150                 155                 160 
Ser Gln Met Thr Glu Val Lys Glu Gln Cys Asp Glu Arg Ile Glu Glu 
                165                 170                 175     
Val Ile Arg Lys Arg Asn Glu Ala Pro Gly Ser Arg Asp Leu Ala Glu 
            180                 185                 190         
Thr Asn Asn Gln His Gln Gln Ala Leu Lys Pro Gln Pro Lys Leu Gln 
        195                 200                 205             
Glu Glu Val Pro Ser Glu Glu Gln Met Pro Gln Glu Lys Gly Asp Val 
    210                 215                 220                 
Pro Arg Asn Lys Ser Gln Ile Pro Ala Pro Asn Ser Glu Ser Leu Gly 
225                 230                 235                 240 
Leu Lys Pro Gln Val Gln Asn Glu Glu Thr Asn Glu Ile Gln Ala Val 
                245                 250                 255     
Gly Glu Glu His Gln Gln Ala Ser Ile Gln Gly Gln Ala Val Ala Asp 
            260                 265                 270         
Gly Thr Arg Val Gly Ala Glu Lys Leu Asp Gln His Thr Gln Leu Pro 
        275                 280                 285             
Ala Gly Leu Leu Ala Arg Pro Glu Glu Asp Ser Gln Tyr Pro Glu Arg 
    290                 295                 300                 
Glu Gln Leu Val Ile Arg Asp Arg Gln Glu Gln Gln Arg Ala Ser Glu 
305                 310                 315                 320 
Glu Gly Gly Gly Gln Lys Asn Pro Gly Asp Glu Tyr Asp Met Asp Glu 
                325                 330                 335     
Asn Glu Ala Glu Ser Glu Arg Glu Lys Gln Ala Ala Leu Ala Gly Asn 
            340                 345                 350         
Asp Arg Asn Ile Asn Val Leu Asn Ala Asp Ala Gln Lys Arg Gly Ile 
        355                 360                 365             
Ile Asn Val Pro Val Gly Ser Glu Arg Gln Ser His Ile Leu Asn Gln 
    370                 375                 380                 
Val Gly Ile His Ile Pro Gln Gln Ala 
385                 390             

<210> 30
<211> 20
<212> PRT
<213> Homo sapiens


<220> 
<223> GP73 aa 36 to 55 UniProt Q8NBJ4

<400> 30
Ser Ser Arg Ser Val Asp Leu Gln Thr Arg Ile Met Glu Leu Glu Gly 
1               5                   10                  15      
Arg Val Arg Arg 
            20  

<210> 31
<211> 20
<212> PRT
<213> Mus musculus


<220> 
<223> GP73 aa 36 to 55 UniProt Q91XA2

<400> 31
Ser Ser Arg Ser Val Glu Leu Gln Thr Arg Ile Val Glu Leu Glu Gly 
1               5                   10                  15      
Arg Val Arg Arg 
            20  

<210> 32
<211> 20
<212> PRT
<213> Canis


<220> 
<223> GP73 aa 36 to 55 UniProt E2RLA5

<400> 32
Ser Ser Arg Ser Val Asp Leu Gln Thr Arg Ile Val Glu Leu Glu Gly 
1               5                   10                  15      
Arg Val Arg Arg 
            20  

<210> 33
<211> 11
<212> PRT
<213> Homo Sapiens


<220> 
<223> epitope of antibodies of the invention

<400> 33
Arg Ile Met Glu Leu Glu Gly Arg Val Arg Arg 
1               5                   10      

<210> 34
<211> 6
<212> PRT
<213> Homo Sapiens


<220> 
<223> epitope of antibodies of the invention

<400> 34
Glu Gly Arg Val Arg Arg 
1               5       

<210> 35
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-2opti (IgG1) and G2-2opti (IgG2a) heavy chain variable region
      (VH)

<400> 35
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Gly Ser Ala Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 36
<211> 115
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-2opti (IgG1) and G2-2opti (IgG2a) light chain variable region
      (VL)

<400> 36
Gln Ala Val Leu Thr Gln Pro Ser Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      
Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Asp Ile Ser Val Gly Phe 
            20                  25                  30          
His Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr 
        35                  40                  45              
Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val 
    50                  55                  60                  
Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Ile 
65                  70                  75                  80  
Leu Leu Ile Ser Gly Leu Gln Ser Asp Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      
Val Ile Trp His Thr Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu 
            100                 105                 110         
Thr Val Leu 
        115 

<210> 37
<211> 123
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-1opti (IgG1) and G2-1opti (IgG2a) heavy chain variable region
      (VH)

<400> 37
Gln Leu Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Arg Ser Tyr Tyr Asp Ser Ser Gly Tyr Leu Phe Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             

<210> 38
<211> 110
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-1opti (IgG1) and G2-1opti (IgG2a) light chain variable region
      (VL)

<400> 38
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      
Thr Val Ile Ile Thr Cys Thr Gly Gly Gly Gly Ser Ile Asp Thr Asn 
            20                  25                  30          
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Val Thr Leu 
        35                  40                  45              
Ile Tyr Glu Asp Asp Gln Arg Pro Phe Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Ala Ala Ile Asp Thr Ser Ser Ser Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  
Leu Thr Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ser His Ser 
                85                  90                  95      
Thr Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 

<210> 39
<211> 330
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-2opti (IgG2a)/ G2-1opti (IgG2a) heavy chain constant region
      (IgG2a)

<400> 39
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
        115                 120                 125             
Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
145                 150                 155                 160 
Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
                165                 170                 175     
Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
            180                 185                 190         
His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
        195                 200                 205             
Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
    210                 215                 220                 
Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
225                 230                 235                 240 
Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
                245                 250                 255     
Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
            260                 265                 270         
Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
        275                 280                 285             
Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
    290                 295                 300                 
Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
305                 310                 315                 320 
Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                325                 330 

<210> 40
<211> 357
<212> PRT
<213> Artificial Sequence


<220> 
<223> GP73 aa 56 to 401-His (sGP73)

<400> 40
Ala Ala Ala Glu Arg Gly Ala Val Glu Leu Lys Lys Asn Glu Phe Gln 
1               5                   10                  15      
Gly Glu Leu Glu Lys Gln Arg Glu Gln Leu Asp Lys Ile Gln Ser Ser 
            20                  25                  30          
His Asn Phe Gln Leu Glu Ser Val Asn Lys Leu Tyr Gln Asp Glu Lys 
        35                  40                  45              
Ala Val Leu Val Asn Asn Ile Thr Thr Gly Glu Arg Leu Ile Arg Val 
    50                  55                  60                  
Leu Gln Asp Gln Leu Lys Thr Leu Gln Arg Asn Tyr Gly Arg Leu Gln 
65                  70                  75                  80  
Gln Asp Val Leu Gln Phe Gln Lys Asn Gln Thr Asn Leu Glu Arg Lys 
                85                  90                  95      
Phe Ser Tyr Asp Leu Ser Gln Cys Ile Asn Gln Met Lys Glu Val Lys 
            100                 105                 110         
Glu Gln Cys Glu Glu Arg Ile Glu Glu Val Thr Lys Lys Gly Asn Glu 
        115                 120                 125             
Ala Val Ala Ser Arg Asp Leu Ser Glu Asn Asn Asp Gln Arg Gln Gln 
    130                 135                 140                 
Leu Gln Ala Leu Ser Glu Pro Gln Pro Arg Leu Gln Ala Ala Gly Leu 
145                 150                 155                 160 
Pro His Thr Glu Val Pro Gln Gly Lys Gly Asn Val Leu Gly Asn Ser 
                165                 170                 175     
Lys Ser Gln Thr Pro Ala Pro Ser Ser Glu Val Val Leu Asp Ser Lys 
            180                 185                 190         
Arg Gln Val Glu Lys Glu Glu Thr Asn Glu Ile Gln Val Val Asn Glu 
        195                 200                 205             
Glu Pro Gln Arg Asp Arg Leu Pro Gln Glu Pro Gly Arg Glu Gln Val 
    210                 215                 220                 
Val Glu Asp Arg Pro Val Gly Gly Arg Gly Phe Gly Gly Ala Gly Glu 
225                 230                 235                 240 
Leu Gly Gln Thr Pro Gln Val Gln Ala Ala Leu Ser Val Ser Gln Glu 
                245                 250                 255     
Asn Pro Glu Met Glu Gly Pro Glu Arg Asp Gln Leu Val Ile Pro Asp 
            260                 265                 270         
Gly Gln Glu Glu Glu Gln Glu Ala Ala Gly Glu Gly Arg Asn Gln Gln 
        275                 280                 285             
Lys Leu Arg Gly Glu Asp Asp Tyr Asn Met Asp Glu Asn Glu Ala Glu 
    290                 295                 300                 
Ser Glu Thr Asp Lys Gln Ala Ala Leu Ala Gly Asn Asp Arg Asn Ile 
305                 310                 315                 320 
Asp Val Phe Asn Val Glu Asp Gln Lys Arg Asp Thr Ile Asn Leu Leu 
                325                 330                 335     
Asp Gln Arg Glu Lys Arg Asn His Thr Leu Ala His His His His His 
            340                 345                 350         
His His His His His 
        355         

<210> 41
<211> 377
<212> PRT
<213> Artificial Sequence


<220> 
<223> GP73 aa 36 to 401 (R52A)-His (GP73-His AVRR)

<400> 41
Ser Ser Arg Ser Val Asp Leu Gln Thr Arg Ile Met Glu Leu Glu Gly 
1               5                   10                  15      
Ala Val Arg Arg Ala Ala Ala Glu Arg Gly Ala Val Glu Leu Lys Lys 
            20                  25                  30          
Asn Glu Phe Gln Gly Glu Leu Glu Lys Gln Arg Glu Gln Leu Asp Lys 
        35                  40                  45              
Ile Gln Ser Ser His Asn Phe Gln Leu Glu Ser Val Asn Lys Leu Tyr 
    50                  55                  60                  
Gln Asp Glu Lys Ala Val Leu Val Asn Asn Ile Thr Thr Gly Glu Arg 
65                  70                  75                  80  
Leu Ile Arg Val Leu Gln Asp Gln Leu Lys Thr Leu Gln Arg Asn Tyr 
                85                  90                  95      
Gly Arg Leu Gln Gln Asp Val Leu Gln Phe Gln Lys Asn Gln Thr Asn 
            100                 105                 110         
Leu Glu Arg Lys Phe Ser Tyr Asp Leu Ser Gln Cys Ile Asn Gln Met 
        115                 120                 125             
Lys Glu Val Lys Glu Gln Cys Glu Glu Arg Ile Glu Glu Val Thr Lys 
    130                 135                 140                 
Lys Gly Asn Glu Ala Val Ala Ser Arg Asp Leu Ser Glu Asn Asn Asp 
145                 150                 155                 160 
Gln Arg Gln Gln Leu Gln Ala Leu Ser Glu Pro Gln Pro Arg Leu Gln 
                165                 170                 175     
Ala Ala Gly Leu Pro His Thr Glu Val Pro Gln Gly Lys Gly Asn Val 
            180                 185                 190         
Leu Gly Asn Ser Lys Ser Gln Thr Pro Ala Pro Ser Ser Glu Val Val 
        195                 200                 205             
Leu Asp Ser Lys Arg Gln Val Glu Lys Glu Glu Thr Asn Glu Ile Gln 
    210                 215                 220                 
Val Val Asn Glu Glu Pro Gln Arg Asp Arg Leu Pro Gln Glu Pro Gly 
225                 230                 235                 240 
Arg Glu Gln Val Val Glu Asp Arg Pro Val Gly Gly Arg Gly Phe Gly 
                245                 250                 255     
Gly Ala Gly Glu Leu Gly Gln Thr Pro Gln Val Gln Ala Ala Leu Ser 
            260                 265                 270         
Val Ser Gln Glu Asn Pro Glu Met Glu Gly Pro Glu Arg Asp Gln Leu 
        275                 280                 285             
Val Ile Pro Asp Gly Gln Glu Glu Glu Gln Glu Ala Ala Gly Glu Gly 
    290                 295                 300                 
Arg Asn Gln Gln Lys Leu Arg Gly Glu Asp Asp Tyr Asn Met Asp Glu 
305                 310                 315                 320 
Asn Glu Ala Glu Ser Glu Thr Asp Lys Gln Ala Ala Leu Ala Gly Asn 
                325                 330                 335     
Asp Arg Asn Ile Asp Val Phe Asn Val Glu Asp Gln Lys Arg Asp Thr 
            340                 345                 350         
Ile Asn Leu Leu Asp Gln Arg Glu Lys Arg Asn His Thr Leu Ala His 
        355                 360                 365             
His His His His His His His His His 
    370                 375         

<210> 42
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Endosomal escape domain (EED)

<400> 42
Met Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly 
1               5                   10                  15      
Gly Ile Val Gly Ser 
            20      

<210> 43
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> EED Linker

<400> 43
Ser Ala Ala Ala Gly Thr 
1               5       

<210> 44
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> G2-1 HVR-L3 variant

<400> 44
Gln Ser Ser His Ser Thr Ala Val Val 
1               5                   

