                         SEQUENCE LISTING



<110>  Pekna, et al.

 

<120>  C3A RECEPTOR AGONISTS



<130>   



<150>  GB1619637.0

<151>  2016-11-21



<160>  8     



<170>  PatentIn version 3.5



<210>  1

<211>  77

<212>  PRT

<213>  Homo sapiens



<400>  1



Ser Val Gln Leu Thr Glu Lys Arg Met Asp Lys Val Gly Lys Tyr Pro 

1               5                   10                  15      





Lys Glu Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Glu Asn Pro Met 

            20                  25                  30          





Arg Phe Ser Cys Gln Arg Arg Thr Arg Phe Ile Ser Leu Gly Glu Ala 

        35                  40                  45              





Cys Lys Lys Val Phe Leu Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg 

    50                  55                  60                  





Arg Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg 

65                  70                  75          





<210>  2

<211>  15

<212>  PRT

<213>  Homo sapiens



<400>  2



Trp Trp Gly Lys Lys Tyr Arg Ala Ser Lys Leu Gly Leu Ala Arg 

1               5                   10                  15  





<210>  3

<211>  6

<212>  PRT

<213>  Homo sapiens



<400>  3



Phe Leu Pro Leu Ala Arg 

1               5       





<210>  4

<211>  9628

<212>  DNA

<213>  Homo sapiens



<400>  4

ctgtgaggtc agatagtggt ctagagcata agacttaact tattgccgga aacagagaga       60



gaacagaaga agagaaagct cagcaaattt tcttgccata cttcatgact tcactgtggc      120



taagtgtggg gaccagacag gactcgtgga gacatccagg tgctgaagcc ttcagctact      180



gtctcagttt tttggtaaga aaacctagac ctacctgatg acttgtgctt agcctgtttt      240



gctcattata ggtaatgagt ttgagtgtca ctatcttcta tttcccctat tccttctctg      300



actttgaatt cttttatctt atctctatgt ctaacttcct ttttctaaat attccacatt      360



gcatttgtct ttgcttttaa tattttcata gtggaattaa tagtgaattt ttacatcatt      420



tctttccttt ctttgaattg gctatgtatt tcaccctgaa ctttgattcc agctgtcccc      480



attaatttgt ttttcaaata attgattgca ctttttttcc ctttccattt cctctttctt      540



ttttttattc ttttgcccat tccttattgc tactgactct gttatcctat tactacaatt      600



tgattctggg gtccactttt ctttctctat cacagtggaa ttttagtttc aggatattaa      660



ttacctttaa attacggctg gtcaacttag taataatttt ttttaatcct ctactaatct      720



taaacacata aaggtatggt atttttagcc aaattaactt gaagaaatgt aaaaagtaat      780



cttgctctgc aggacttttt tttttttttt ttttttttga gacagagtct cactctgttg      840



cccaggctgg agtacagtag catgatctca gctcactgca acctccgcct cccaggttca      900



agcgattctc ctgcctcagc ctcctgagta ggtgggattg caggcacgtg ctaccacacc      960



cagttaaatt tttttgtatt tttagtagag acagggttcc accatgttgg ccaggttggt     1020



ctcaaactcc tgacctcagg tgatctaccc gcctctgcct cccaaagtgc tgggattaca     1080



ggcgtgagcc accacaccca gccttgttct aaaggacttt taatccctga ctcctacata     1140



ctttcatttc aaaacagata ataacaatat ttaacatata gctcatgaca gataactcta     1200



tttttattaa aattttgctg tttgcagtcc ctgctacttc agttcatgca gttctcggca     1260



gcttcccctt tattagcaat accatatatc tttttttttt taatgtgatt tttttttttt     1320



tttggtagta aaaacagcat ttgcctaaca gtcctcggac ctgaaatcca agaacctccc     1380



tagtaatgat tatatgcttg taatctaatt tgctgagttt cactgtcaaa cttgagaaat     1440



aaaagcagag aaaacgtagg ctgggcacag tggctcatgt ctgtaacccc agcacactgt     1500



gaggccaaca tgggaggatt gcttgagtcc aggagtttga gagcagcttg ggcaacatag     1560



caagacccta tctctacaaa caaacaaaca aacaaacaac aacaacaaca acaaaatgag     1620



gagaggagag atgattacca agttttcttt cagccctagc atcccatgac tctattcttc     1680



tctcaatatt ttaggggggt accgtgatag tatttaaata tctgagtaga caaggccatg     1740



gaaaggggaa tgagaataat ttcttcttct tttttttttt ttgagatgga gttttgcttt     1800



tgttgcccag gctggagtgt agtggcgcaa cctcggctca ccacaacctc tgcctcccag     1860



gttcaagcga ttctcctgcc tcagcctcct gagtagctgg gattacaggc atgtgccacc     1920



atgcccacct aattttgtat ttttagtaga gacagagttt ctccatgttg gataggctgg     1980



tctcaaactg acctcaggtg atctgcctgc cttggcttcc caaagtgctg ggataacagg     2040



tgtgagccac tgtgcccagc ccatgtcttc ttttttatta ttttgttgac ttgctatttt     2100



aacttctgct aatcatatga ggccctatgg caatatttgg ctgactcagc agaactactt     2160



tcaagtcaca aaaatatttt gagcctctat aaaagtaaaa tgttatttta tccagtaaaa     2220



attaggaatt tcacaaaaag aaagttaaaa gggacagcat gggaattaag gaagaggcct     2280



gggtaaggat tacatggata caaattagaa ttttagatgt aattgcaaaa gaaaaaaaaa     2340



gtcaaccccc aaaatgggca tccatctatt caagtaattt tttttttctt tttttttctt     2400



ttgagacaga gtctctttgt catgcaggct ggagtgcagt ggtgcaatct cagctcactg     2460



caacctccac ctctccagtt caagcgattc tcgtgcctca gcctcccaag tagctgggat     2520



tacaagtgtg agctaccaca cccagctaat ttttgtattt ttggtagaga tgggattttg     2580



ccatgttagc caggctggtc ttgaactcct agccccaagc gatcttctcc cctcggcccc     2640



ccaaagtgct gcgattacag gcatgagcca ctgcgcccag cctttccaca taatctttaa     2700



ccttggtgtc tcataaggca ttatgttaaa ttatgtgaaa tgagcattta tgaataagac     2760



tcctttttac catcataaag tttaaatcca gaataataga ttagacagcc attataatta     2820



ttgtacaaga taaaatgtgt cattgcatat agaatatgaa aaaaaggttc aaacatgcgc     2880



acacacacaa attaagaagc tgaagacttg gtgaagggca taattccaga tagaagtaaa     2940



cagcattagc catggaacgg aaaatggcat taagttggaa tagtgaattg ttcaggaaag     3000



ctataaagca gggtacattt acgagcatgt tcacagttag gggaaggtaa tatcacagag     3060



gccaagagaa gagagtgtta agaagtcagt gtatctaatg acacatattg tggaaggtga     3120



ctgagaaaca aacgtttgga tttggttttt agaagtaatt ttagcagaat tatggaagca     3180



gaagatacat tacaaagaat taagaagttg gtggccggcc gggcctggtg gctcacatct     3240



gtaatcccgg gactttggga ggccgaggcg ggcggatcac caggtcagga aatcaagatc     3300



atcctggcta acatggtgaa accccgtctc tactaaaaat acaaaaatta gccgggcgtg     3360



gtggtacacg cctgtaatcc cagctcctcg ggaggctgag gcagaagaat tgcttaaacc     3420



cgggatgcgg aggctgtagt gagccgagat cgcaccattg cactccagcc tgggagacag     3480



agcgagactc catcacaaaa aaaaaaaaaa aaaaaaaaaa aagggccggg cgcggtggct     3540



cacgcctgta atcccaacac tttgggaggc cgaggcgggc ggatcgcctg aggtcgggag     3600



atcaacatca tcctggccaa catggagaaa ccccgttctc tactaaaaat acaaaaaaaa     3660



attagccggg catggtggcg catgcctgta atcccagcta ctgggaggct gaggcaggag     3720



aatcacttga acccgggagg aggaggttgc agtgagccaa gatcgcgcca ctgcactcca     3780



gcgtgggcaa caagagcgaa actccatctc aagaaaaaag aaaaaaagaa gaagttagtg     3840



ttcagaacag taggcgtagg ccccaaaaca aagcagtatc cttgaaaaag agaaattatg     3900



ctaaattaag agacttaaga agaaagtgcg atctgaagta gatattgtcg tggacaagcc     3960



agctataaaa gatgtcttag ggacagttga aaaataatca tataaaaggg ggggcatggt     4020



ggttcgtgcc tgtaatctca gcacttcggg aggccgagga agaatcagta gagcccagga     4080



gttggagacc agcctgagca acatagcaag accccatctt tacaaacaga aacaaaacag     4140



ataaaggtcg ggtattcctt atggtacata ttgtataatg tggagactgc taactgaaaa     4200



aagaaaaaaa tgtataaaaa atatgtattt acacccatgt tcattgatgc ataattcaca     4260



atagtcaaaa ggtgaaagca atccagatgt cctctgtgga atgactggat aaacaaaatg     4320



aagtatagac ctacaatgga atattattca gccttaaaaa gaaagaaaat tctgacccat     4380



gccacaacgc ggaggaagct tgaagacatt atgctaagtg aaatacacca gacacaaaaa     4440



gacaaatact gtgtgattcc acttagatca gatatctaaa gtagtcgaat tcatagaaat     4500



tgaaagtaca atggtgattg ccaggggctg agaaaaggag aaaatgggga attctttcct     4560



gagcacattt tcagttttgt aagatgaaaa agttctgaaa attggttgta caacgtgaat     4620



atggtaaaca ctactgaact gtgtacttaa aaatggtgaa gatggtaaat gttatgatac     4680



atgtgtttgg caattaaaat ttttttgtta gggccaggcg cggtggctcg cacctgtaat     4740



cccagcactt tgggagggag aggagggagg atcactcgag cctagcagtt caagagtagc     4800



ctggccaaca tggcaaaacc tgtctctgct aaaaatacaa aaattagttg gtacgttggt     4860



gggcaactgc agtcccagct actcaggagg ctgaggcacg ataattgctt gaacccggga     4920



ggcagaggct gcagtgagcc gagattgtat cactgcactc cagcctgaat gacggaggga     4980



gattctgtct caaaaataat aataataata ataataaata aataaatgaa gcactgtccc     5040



acatattaga aggcttctag ccatcacagc ccctgctgtc taaagatacg catgtgtata     5100



cctaaatgca cacacacaca taaaaaaagg tcaagaggat ataaattcag gtgctaaaat     5160



aataatcact gactagtgag tatattttta ttttcttttt tgtttgtcta tattttccaa     5220



ttttcttcat gcatattttt tgcttttgta ataataaagc tcttttccca agttacggtc     5280



ataaaacaca aataaataag aaagaaatga taggtagtga ggaagtcaat gcagagggcc     5340



aacaactctt ggaaaatttg aaagcaaaag gagatggagt tgtatctaaa agacatcgct     5400



gagtctagag tacctctttc tgtggcggcg agtcctctga aaatctggtg gggagagtgg     5460



atgaagcttc tgccctcaga gaaatgagaa tatgtaaagt tgaagttttg catatcattt     5520



taggtggtga tggaacttcc taaaaccctt tcgtgacctc aggttggaga cctccagtcc     5580



agatattttt gtgtgtttac ttatttagct tatttgttta tttttaaaca cactgggtga     5640



agaaaggagc cagtggaaaa accaagattg aaagtacaag aaagaggaga aatttacact     5700



aatatggact tccagatgag gctgtgattt tgatacacac ataaatcaat acagtagatt     5760



ttaaattgtc tatcatagga tgggcatggt ggctcatgcc tataatccca gcactttggg     5820



aggccaaggc aggcagatca cccgaggtca ggagttcaag accagcctgg ccaacatggc     5880



aaaaccccgt ctctactaaa aatacaaaaa ttagccaggc gtggtggtgc acgcctgtaa     5940



tcccagctac tctggaggct gaggcaggag aatcgcttga actcgggagg cggagcttac     6000



agtgagctga aatcaatcca ctgcactcca gcctgcgcga cagaggaaga ctctgtctga     6060



aaaataatta ataaattaat aaataaatat aattgtctat cagagaatgc ttttatgtgg     6120



tcccgtgtga ggtgaaggaa ggcaaactaa aacagcgtga ggaccttctg gtttcatgat     6180



cccacatctt tatgtgggaa gattagaatc ctaagaatat gtatgcattt tcaaaaagat     6240



actgtttgtt ttaacatttt tttcatcttt ttgcagaagt ttagcaatgg cgtctttctc     6300



tgctgagacc aattcaactg acctactctc acagccatgg aatgagcccc cagtaattct     6360



ctccatggtc attctcagcc ttactttttt actgggattg ccaggcaatg ggctggtgct     6420



gtgggtggct ggcctgaaga tgcagcggac agtgaacaca atttggttcc tccacctcac     6480



cttggcggac ctcctctgct gcctctcctt gcccttctcg ctggctcact tggctctcca     6540



gggacagtgg ccctacggca ggttcctatg caagctcatc ccctccatca ttgtcctcaa     6600



catgtttgcc agtgtcttcc tgcttactgc cattagcctg gatcgctgtc ttgtggtatt     6660



caagccaatc tggtgtcaga atcatcgcaa tgtagggatg gcctgctcta tctgtggatg     6720



tatctgggtg gtggcttttg tgatgtgcat tcctgtgttc gtgtaccggg aaatcttcac     6780



tacagacaac cataatagat gtggctacaa atttggtctc tccagctcat tagattatcc     6840



agacttttat ggagatccac tagaaaacag gtctcttgaa aacattgttc agccgcctgg     6900



agaaatgaat gataggttag atccttcctc tttccaaaca aatgatcatc cttggacagt     6960



ccccactgtc ttccaacctc aaacatttca aagaccttct gcagattcac tccctagggg     7020



ttctgctagg ttaacaagtc aaaatctgta ttctaatgta tttaaacctg ctgatgtggt     7080



ctcacctaaa atccccagtg ggtttcctat tgaagatcac gaaaccagcc cactggataa     7140



ctctgatgct tttctctcta ctcatttaaa gctgttccct agcgcttcta gcaattcctt     7200



ctacgagtct gagctaccac aaggtttcca ggattattac aatttaggcc aattcacaga     7260



tgacgatcaa gtgccaacac ccctcgtggc aataacgatc actaggctag tggtgggttt     7320



cctgctgccc tctgttatca tgatagcctg ttacagcttc attgtcttcc gaatgcaaag     7380



gggccgcttc gccaagtctc agagcaaaac ctttcgagtg gccgtggtgg tggtggctgt     7440



ctttcttgtc tgctggactc cataccacat ttttggagtc ctgtcattgc ttactgaccc     7500



agaaactccc ttggggaaaa ctctgatgtc ctgggatcat gtatgcattg ctctagcatc     7560



tgccaatagt tgctttaatc ccttccttta tgccctcttg gggaaagatt ttaggaagaa     7620



agcaaggcag tccattcagg gaattctgga ggcagccttc agtgaggagc tcacacgttc     7680



cacccactgt ccctcaaaca atgtcatttc agaaagaaat agtacaactg tgtgaaaatg     7740



tggagcagcc aacaagcagg ggctcttagg caatcacata gtgaaagttt ataagaggat     7800



gaagtgatat ggtgagcagc ggacttcaaa aactgtcaaa gaatcaatcc agcggttctc     7860



aaacggtaca cagactattg acatcagcat cacctagaaa cttgttagaa atgcaaattc     7920



tcaagccgca tcccagactt gctgaatcgg aatctctggg ggttgggacc cagcaagggc     7980



acttaacaaa ccctcgtttc tgattaatgc taaatgtaag aatcattgta aacattagtt     8040



ctatttctat cccaaactaa gctatgtgaa ataagagaag ctactttgtt tttaaatgat     8100



gttgaatatt tgtcgatatt tccatcatta aatttttcct tagcattgtc taagtcttcc     8160



agattccatt taaaaccatt tcttgttctc ctacgtgagt gaaagatgat catatatcct     8220



aatgctttgt tgtcgtgtgg tgttgatggt tttaaacgaa aagaaagtgc aaaaagaaaa     8280



tgcctgtgaa gacaagaagc catgagactg agtctggagc atagggttat gcaatgatgc     8340



ctgtccctgg gaacacccct gggtacagga tatagaaatt tccactatta catagagttt     8400



ccactattac aactaaataa gcatctattg tgtgaaaact gactcatgaa atgttatgaa     8460



agctgtggtt tggggagttc tgtttcttct aactgcctac cggttgggca cctattttcc     8520



actcctcttc ctaagctcct taatttcctt attactcccc agcctccaaa tcttccacat     8580



cagactttgt gcctcaaaca acctctaatt tcgtaagatt ctagttactc ccttcctctt     8640



gctccaaatg aatactttct aagaaagtat ttcaagtgga aggagaaaga gggtggagga     8700



tggagcagca attcttctac tctctgcaac tgagtaccct accaggcttg ccatcacatt     8760



ttaaaacatg acgacaggca acttacatgc caaaattacc aaatatatct tctgggtttt     8820



ttaaatcctt ttctttgcca aagtaataca tgcacatagt tttaaaataa tttaataagg     8880



tatataatga aatatgaggt ctcctacctc actgtgccca aaagttccct cctcccactc     8940



tcatttccca gagataatcc ttgcacaatt ttagatgttt cctttgataa ttatcatgat     9000



gtttctaaat catgtgctta tgctgctctt ttctggaggc atgataaaac gacttcttgt     9060



tttgaaagat gaagatgttt atccaagcac cccatatttt taatttgttt atccagcatc     9120



ccaacattca ttaataacca tattttaatt cattcatgac cacatatttt tcttctactt     9180



tgtctataca ctccaaccat ttatatagct ttccttctgt ccctttttca tttaaaacaa     9240



aattacctaa ctccctacca ccttctcatt tttctgtata tataaatgtt tgtgtcaaac     9300



gtctgaaatt tctggcttgt ttgtatcaca acgtggcctc atctaaacca aatacaatga     9360



tgtagtctaa aaacagaaaa tgacatgtgt tttagacctg caagacacta tctgttcaat     9420



ggctgaggtg agggtctgga ctacagattt tttataaagt atatgcagaa aaattacaaa     9480



tcactaggaa ttctttcagt tgtgaagaat gtctgacata agatttgaag tgctaccttt     9540



ccagcttata tattaatttg cttatatatt tgatatgaat aaatgctttt tttctcatgg     9600



gtccttgcga ggctcagaga tttatgaa                                        9628





<210>  5

<211>  482

<212>  PRT

<213>  Homo sapiens



<400>  5



Met Ala Ser Phe Ser Ala Glu Thr Asn Ser Thr Asp Leu Leu Ser Gln 

1               5                   10                  15      





Pro Trp Asn Glu Pro Pro Val Ile Leu Ser Met Val Ile Leu Ser Leu 

            20                  25                  30          





Thr Phe Leu Leu Gly Leu Pro Gly Asn Gly Leu Val Leu Trp Val Ala 

        35                  40                  45              





Gly Leu Lys Met Gln Arg Thr Val Asn Thr Ile Trp Phe Leu His Leu 

    50                  55                  60                  





Thr Leu Ala Asp Leu Leu Cys Cys Leu Ser Leu Pro Phe Ser Leu Ala 

65                  70                  75                  80  





His Leu Ala Leu Gln Gly Gln Trp Pro Tyr Gly Arg Phe Leu Cys Lys 

                85                  90                  95      





Leu Ile Pro Ser Ile Ile Val Leu Asn Met Phe Ala Ser Val Phe Leu 

            100                 105                 110         





Leu Thr Ala Ile Ser Leu Asp Arg Cys Leu Val Val Phe Lys Pro Ile 

        115                 120                 125             





Trp Cys Gln Asn His Arg Asn Val Gly Met Ala Cys Ser Ile Cys Gly 

    130                 135                 140                 





Cys Ile Trp Val Val Ala Phe Val Met Cys Ile Pro Val Phe Val Tyr 

145                 150                 155                 160 





Arg Glu Ile Phe Thr Thr Asp Asn His Asn Arg Cys Gly Tyr Lys Phe 

                165                 170                 175     





Gly Leu Ser Ser Ser Leu Asp Tyr Pro Asp Phe Tyr Gly Asp Pro Leu 

            180                 185                 190         





Glu Asn Arg Ser Leu Glu Asn Ile Val Gln Pro Pro Gly Glu Met Asn 

        195                 200                 205             





Asp Arg Leu Asp Pro Ser Ser Phe Gln Thr Asn Asp His Pro Trp Thr 

    210                 215                 220                 





Val Pro Thr Val Phe Gln Pro Gln Thr Phe Gln Arg Pro Ser Ala Asp 

225                 230                 235                 240 





Ser Leu Pro Arg Gly Ser Ala Arg Leu Thr Ser Gln Asn Leu Tyr Ser 

                245                 250                 255     





Asn Val Phe Lys Pro Ala Asp Val Val Ser Pro Lys Ile Pro Ser Gly 

            260                 265                 270         





Phe Pro Ile Glu Asp His Glu Thr Ser Pro Leu Asp Asn Ser Asp Ala 

        275                 280                 285             





Phe Leu Ser Thr His Leu Lys Leu Phe Pro Ser Ala Ser Ser Asn Ser 

    290                 295                 300                 





Phe Tyr Glu Ser Glu Leu Pro Gln Gly Phe Gln Asp Tyr Tyr Asn Leu 

305                 310                 315                 320 





Gly Gln Phe Thr Asp Asp Asp Gln Val Pro Thr Pro Leu Val Ala Ile 

                325                 330                 335     





Thr Ile Thr Arg Leu Val Val Gly Phe Leu Leu Pro Ser Val Ile Met 

            340                 345                 350         





Ile Ala Cys Tyr Ser Phe Ile Val Phe Arg Met Gln Arg Gly Arg Phe 

        355                 360                 365             





Ala Lys Ser Gln Ser Lys Thr Phe Arg Val Ala Val Val Val Val Ala 

    370                 375                 380                 





Val Phe Leu Val Cys Trp Thr Pro Tyr His Ile Phe Gly Val Leu Ser 

385                 390                 395                 400 





Leu Leu Thr Asp Pro Glu Thr Pro Leu Gly Lys Thr Leu Met Ser Trp 

                405                 410                 415     





Asp His Val Cys Ile Ala Leu Ala Ser Ala Asn Ser Cys Phe Asn Pro 

            420                 425                 430         





Phe Leu Tyr Ala Leu Leu Gly Lys Asp Phe Arg Lys Lys Ala Arg Gln 

        435                 440                 445             





Ser Ile Gln Gly Ile Leu Glu Ala Ala Phe Ser Glu Glu Leu Thr Arg 

    450                 455                 460                 





Ser Thr His Cys Pro Ser Asn Asn Val Ile Ser Glu Arg Asn Ser Thr 

465                 470                 475                 480 





Thr Val 

        





<210>  6

<211>  6

<212>  PRT

<213>  Homo sapiens



<400>  6



Phe Ile Pro Leu Ala Arg 

1               5       





<210>  7

<211>  6

<212>  PRT

<213>  Homo sapiens



<400>  7



Phe Trp Thr Leu Ala Arg 

1               5       





<210>  8

<211>  6

<212>  PRT

<213>  Homo sapiens



<400>  8



Phe Leu Thr Leu Ala Arg 

1               5       





