                         SEQUENCE LISTING

<110>  INSERM
 
<120>  METHODS AND PHARMACEUTICAL COMPOSITIONS FOR INCREASING ENDOGENOUS
        PROTEIN LEVEL

<130>  LENTING 16424

<160>  94    

<170>  PatentIn version 3.3

<210>  1
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  SEQ ID NO: 1

<400>  1

Gln Gly Leu Ile Gly Asp Ile Ala Leu Pro Arg Trp Gly Ala Leu Trp 
1               5                   10                  15      


Gly Asp Ser Val 
            20  


<210>  2
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  KB-VWF-013 CDR1 SEQ ID NO: 2

<400>  2

Gly Arg Thr Phe Ile Arg Tyr Ala Met Ala 
1               5                   10  


<210>  3
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  KB-VWF-013 CDR2 SEQ ID NO: 3  

<400>  3

Ile Pro Gln Ser Gly Gly Arg Ser Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  4
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  KB-VWF-013 CDR3 SEQ ID NO: 4 

<400>  4

Thr Ser Thr Tyr Tyr Gly Arg Ser Ala Tyr Ser Ser His Ser Gly Gly 
1               5                   10                  15      


Tyr Asp Tyr 
            


<210>  5
<211>  128
<212>  PRT
<213>  Artificial

<220>
<223>  KB-VWF-013 SEQ ID NO: 5

<400>  5

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ile Arg Tyr 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Pro Gln Ser Gly Gly Arg Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Ala Ala Thr Ser Thr Tyr Tyr Gly Arg Ser Ala Tyr Ser Ser His Ser 
            100                 105                 110         


Gly Gly Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  6
<211>  309
<212>  PRT
<213>  Artificial

<220>
<223>  KB-VWF-013bv-ABP SEQ ID NO: 6

<400>  6

Gln Val Gln Leu Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Asp Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ile Arg Tyr Ala 
            20                  25                  30          


Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
        35                  40                  45              


Ala Ile Pro Gln Ser Gly Gly Arg Ser Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys Ala 
                85                  90                  95      


Ala Thr Ser Thr Tyr Tyr Gly Arg Ser Ala Tyr Ser Ser His Ser Gly 
            100                 105                 110         


Gly Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Asp Ser 
145                 150                 155                 160 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ile Arg Tyr Ala 
                165                 170                 175     


Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
            180                 185                 190         


Ala Ile Pro Gln Ser Gly Gly Arg Ser Tyr Tyr Ala Asp Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys Ala 
225                 230                 235                 240 


Ala Thr Ser Thr Tyr Tyr Gly Arg Ser Ala Tyr Ser Ser His Ser Gly 
                245                 250                 255     


Gly Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
            260                 265                 270         


Arg Gly Gly Gly Ser Leu Thr Pro Arg Gly Val Arg Leu Gly Gly Gly 
        275                 280                 285             


Ser Gln Gly Leu Ile Gly Asp Ile Ala Leu Pro Arg Trp Gly Ala Leu 
    290                 295                 300                 


Trp Gly Asp Ser Val 
305                 


<210>  7
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  KB-VWF-008 CDR1 SEQ ID NO: 7

<400>  7

Gly Arg Thr Phe Ser Asp Tyr Ala Met Gly 
1               5                   10  


<210>  8
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>   KB-VWF-008 CDR2 SEQ ID NO: 8

<400>  8

Ile Asn Arg Ser Gly Gly Arg Leu Ser Tyr Ala Glu Ser Val Asn Asp 
1               5                   10                  15      


<210>  9
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  KB-VWF-008 CDR3 SEQ ID NO: 9

<400>  9

Arg Thr Asn Trp Asn Pro Pro Arg Pro Leu Pro Glu Glu Tyr Asn Tyr 
1               5                   10                  15      


<210>  10
<211>  125
<212>  PRT
<213>  Artificial

<220>
<223>  KB-VWF-008 SEQ ID NO: 10

<400>  10

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Gly Cys Ile Leu Gln Asn Pro Gly Lys Glu Arg Asp Phe Val 
        35                  40                  45              


Ala Ser Ile Asn Arg Ser Gly Gly Arg Leu Ser Tyr Ala Glu Ser Val 
    50                  55                  60                  


Asn Asp Leu Phe Thr Ile Ser Val Asp Asn Ala Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Val Leu Arg Thr Asn Trp Asn Pro Pro Arg Pro Leu Pro Glu Glu Tyr 
            100                 105                 110         


Asn Tyr Trp Gly Gln Glu Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  11
<211>  304
<212>  PRT
<213>  Artificial

<220>
<223>  KB-VWF-008bv-ABP SEQ ID NO: 11

<400>  11

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Met Gly Cys Ile Leu Gln Asn Pro Gly Lys Glu Arg Asp Phe Val 
        35                  40                  45              


Ala Ser Ile Asn Arg Ser Gly Gly Arg Leu Ser Tyr Ala Glu Ser Val 
    50                  55                  60                  


Asn Asp Leu Phe Thr Ile Ser Val Asp Asn Ala Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Val Leu Arg Thr Asn Trp Asn Pro Pro Arg Pro Leu Pro Glu Glu Tyr 
            100                 105                 110         


Asn Tyr Trp Gly Gln Glu Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln 
    130                 135                 140                 


Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Asp Ser Leu Lys 
145                 150                 155                 160 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asp Tyr Ala Met Gly 
                165                 170                 175     


Cys Ile Leu Gln Asn Pro Gly Lys Glu Arg Asp Phe Val Ala Ser Ile 
            180                 185                 190         


Asn Arg Ser Gly Gly Arg Leu Ser Tyr Ala Glu Ser Val Asn Asp Leu 
        195                 200                 205             


Phe Thr Ile Ser Val Asp Asn Ala Lys Asn Met Leu Tyr Leu Gln Met 
    210                 215                 220                 


Asn Ser Leu Lys Pro Glu Asp Thr Ala Val His Tyr Cys Val Leu Arg 
225                 230                 235                 240 


Thr Asn Trp Asn Pro Pro Arg Pro Leu Pro Glu Glu Tyr Asn Tyr Trp 
                245                 250                 255     


Gly Gln Glu Thr Gln Val Thr Val Ser Ser Gly Arg Gly Gly Gly Ser 
            260                 265                 270         


Leu Thr Pro Arg Gly Val Arg Leu Gly Gly Gly Ser Gln Gly Leu Ile 
        275                 280                 285             


Gly Asp Ile Ala Leu Pro Arg Trp Gly Ala Leu Trp Gly Asp Ser Val 
    290                 295                 300                 


<210>  12
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  KB-VWF-011 CDR1 SEQ ID NO: 12

<400>  12

Gly Gly Thr Phe Ser Asn Tyr Ala Met Gly 
1               5                   10  


<210>  13
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  KB-VWF-011 CDR2 SEQ ID NO: 13

<400>  13

Ile Ser Arg Ser Gly His Arg Thr Asp Tyr Ala Asp Ser Ala Lys Gly 
1               5                   10                  15      


<210>  14
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  KB-VWF-011 CDR3 SEQ ID NO: 14

<400>  14

Arg Ser Asp Trp Ser Ile Ala Thr Thr Ala Thr Ser Tyr Asp Tyr 
1               5                   10                  15  


<210>  15
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>   KB-VWF-011 SEQ ID NO: 15

<400>  15

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Ser Arg Ser Gly His Arg Thr Asp Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Ser Asp Trp Ser Ile Ala Thr Thr Ala Thr Ser Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  16
<211>  302
<212>  PRT
<213>  Artificial

<220>
<223>  KB-VWF-011bv-ABP SEQ ID NO: 16

<400>  16

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Ser Arg Ser Gly His Arg Thr Asp Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Ser Asp Trp Ser Ile Ala Thr Thr Ala Thr Ser Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu 
    130                 135                 140                 


Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Asp Ser Leu Arg Leu 
145                 150                 155                 160 


Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Asn Tyr Ala Met Gly Trp 
                165                 170                 175     


Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val Ala Arg Ile Ser 
            180                 185                 190         


Arg Ser Gly His Arg Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe 
        195                 200                 205             


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn 
    210                 215                 220                 


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg Ser 
225                 230                 235                 240 


Asp Trp Ser Ile Ala Thr Thr Ala Thr Ser Tyr Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Gln Val Thr Val Ser Ser Gly Arg Gly Gly Gly Ser Leu Thr 
            260                 265                 270         


Pro Arg Gly Val Arg Leu Gly Gly Gly Ser Gln Gly Leu Ile Gly Asp 
        275                 280                 285             


Ile Ala Leu Pro Arg Trp Gly Ala Leu Trp Gly Asp Ser Val 
    290                 295                 300         


<210>  17
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-001 CDR1 SEQ ID NO: 17

<400>  17

Gly Arg Thr Phe Arg Asn Tyr Val 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-001 CDR2 SEQ ID NO: 18

<400>  18

Ile Asn Arg Ser Gly Ala Ile Thr 
1               5               


<210>  19
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-001 CDR3 SEQ ID NO: 19

<400>  19

Ala Ala Gly Glu Thr Thr Trp Ser Ile Arg Arg Asp Asp Tyr Asp Tyr 
1               5                   10                  15      


<210>  20
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-001 SEQ ID NO: 20

<400>  20

Gln Val Gln Leu Gln Gln Ser Gly Gly Asp Leu Ala Gln Arg Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg Asn Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Pro Glu Phe Ile 
        35                  40                  45              


Ala Gly Ile Asn Arg Ser Gly Ala Ile Thr Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Glu Thr Thr Trp Ser Ile Arg Arg Asp Asp Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  21
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-002 CDR1 SEQ ID NO: 21

<400>  21

Ser Gly Arg Thr Phe Asn Asn Asn Gly 
1               5                   


<210>  22
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-002 CDR2 SEQ ID NO: 22

<400>  22

Ile Ser Trp Ser Gly Gly Ser Thr 
1               5               


<210>  23
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-002 CDR3 SEQ ID NO: 23

<400>  23

Ala Ala Arg Thr Arg Tyr Asn Ser Gly Leu Phe Ser Arg Asn Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  24
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-002 SEQ ID NO: 24

<400>  24

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Asn 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Tyr Ile Met Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Thr Arg Tyr Asn Ser Gly Leu Phe Ser Arg Asn Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  25
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-003 CDR1 SEQ ID NO: 25

<400>  25

Ala Leu Thr Phe Ser Ser Arg Ala Trp 
1               5                   


<210>  26
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-003 CDR2 SEQ ID NO: 26

<400>  26

Ile Thr Gly Gly Gly Thr Thr Asn 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-003 CDR3 SEQ ID NO: 27

<400>  27

Asn Gly Tyr Arg Tyr Thr Tyr Ala 
1               5               


<210>  28
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-003 SEQ ID NO: 28

<400>  28

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Leu Thr Phe Ser Ser Arg 
            20                  25                  30          


Ala Trp Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Thr Gly Gly Gly Thr Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val His Tyr Cys Asn 
                85                  90                  95      


Gly Tyr Arg Tyr Thr Tyr Ala Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  29
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-004  CDR1 SEQ ID NO: 29

<400>  29

Ala Met Thr Phe Ser Ile Arg 
1               5           


<210>  30
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-004 CDR2 SEQ ID NO: 30

<400>  30

Ile Gly Thr Gly Asp Ile Thr 
1               5           


<210>  31
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-004  CDR3 SEQ ID NO: 31

<400>  31

Asn Gly Tyr Arg Ser Thr Tyr Ala 
1               5               


<210>  32
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-004 SEQ ID NO: 32

<400>  32

Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Ala Met Thr Phe Ser Ile Arg Ala 
            20                  25                  30          


Trp Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
        35                  40                  45              


Ser Ile Gly Thr Gly Asp Ile Thr Asn Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Phe Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Gly 
                85                  90                  95      


Tyr Arg Ser Thr Tyr Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  33
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-005 CDR1 SEQ ID NO: 33

<400>  33

Gly Arg Asp Phe Asn Asp Ala Ala Leu 
1               5                   


<210>  34
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-005 CDR2 SEQ ID NO: 34

<400>  34

Ile Thr Ser Gly Gly Val Arg 
1               5           


<210>  35
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-005 CDR3 SEQ ID NO: 35

<400>  35

Lys Ala Asp Ser Phe Lys Gly Asp Tyr Asp Thr Ser Trp Tyr Leu Tyr 
1               5                   10                  15      


<210>  36
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-005 SEQ ID NO: 36

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Arg Asp Phe Asn Asp Ala 
            20                  25                  30          


Ala Leu Gly Trp Ser Arg Gln Val Pro Gly Lys Ala Arg Glu Thr Val 
        35                  40                  45              


Ala Met Ile Thr Ser Gly Gly Val Arg Asn Tyr Ala Glu Thr Val Lys 
    50                  55                  60                  


Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Asp Met Asn Asn Leu Gln Pro Asp Asp Thr Gly Val Tyr Tyr Cys Lys 
                85                  90                  95      


Ala Asp Ser Phe Lys Gly Asp Tyr Asp Thr Ser Trp Tyr Leu Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  37
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-006  CDR1 SEQ ID NO: 37

<400>  37

Gly Arg Thr Phe Ser Asn Asn Gly 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-006 CDR2 SEQ ID NO: 38

<400>  38

Ile Ser Trp Ser Ser Gly Ser Thr 
1               5               


<210>  39
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-006 CDR3 SEQ ID NO: 39

<400>  39

Ala Ala Arg Thr Arg Tyr Asn Ser Gly Tyr Phe Thr Arg Asn Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  40
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-006 SEQ ID NO: 40

<400>  40

Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Asn 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Tyr Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Thr Arg Tyr Asn Ser Gly Tyr Phe Thr Arg Asn Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  41
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-007 CDR1 SEQ ID NO: 41

<400>  41

Gly Arg Thr Phe Arg Asn Tyr Val 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-007 CDR2 SEQ ID NO: 42

<400>  42

Ile Asn Arg Ser Gly Ala Ile Thr 
1               5               


<210>  43
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-007 CDR3 SEQ ID NO: 43

<400>  43

Ala Ala Gly Glu Thr Thr Trp Ser Ile Arg Arg Asp Asp Tyr Asp Tyr 
1               5                   10                  15      


<210>  44
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-007 SEQ ID NO: 44

<400>  44

Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg Asn Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Pro Glu Phe Ile 
        35                  40                  45              


Ala Gly Ile Asn Arg Ser Gly Ala Ile Thr Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Glu Thr Thr Trp Ser Ile Arg Arg Asp Asp Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  45
<211>  254
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-002/003 SEQ ID NO: 45

<400>  45

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Asn 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Tyr Ile Met Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Thr Arg Tyr Asn Ser Gly Leu Phe Ser Arg Asn Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu 
    130                 135                 140                 


Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
145                 150                 155                 160 


Ser Cys Ala Ala Ser Ala Leu Thr Phe Ser Ser Arg Ala Trp Ala Trp 
                165                 170                 175     


Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ser Ile Thr 
            180                 185                 190         


Gly Gly Gly Thr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
        195                 200                 205             


Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
    210                 215                 220                 


Leu Lys Pro Glu Asp Thr Ala Val His Tyr Cys Asn Gly Tyr Arg Tyr 
225                 230                 235                 240 


Thr Tyr Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 


<210>  46
<211>  263
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-001/002 SEQ ID NO: 46

<400>  46

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg Asn Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Pro Glu Phe Ile 
        35                  40                  45              


Ala Gly Ile Asn Arg Ser Gly Ala Ile Thr Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Glu Thr Thr Trp Ser Ile Arg Arg Asp Asp Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val 
    130                 135                 140                 


Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser 
145                 150                 155                 160 


Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Asn Gly Met Gly Trp Phe 
                165                 170                 175     


Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Trp 
            180                 185                 190         


Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Tyr Ile 
        195                 200                 205             


Met Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
    210                 215                 220                 


Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg Thr Arg 
225                 230                 235                 240 


Tyr Asn Ser Gly Leu Phe Ser Arg Asn Tyr Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Gln Val Thr Val Ser Ser 
            260             


<210>  47
<211>  256
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-001/003 SEQ ID NO: 47

<400>  47

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg Asn Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Pro Glu Phe Ile 
        35                  40                  45              


Ala Gly Ile Asn Arg Ser Gly Ala Ile Thr Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Glu Thr Thr Trp Ser Ile Arg Arg Asp Asp Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Gln 
    130                 135                 140                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
145                 150                 155                 160 


Cys Ala Ala Ser Ala Leu Thr Phe Ser Ser Arg Ala Trp Ala Trp Tyr 
                165                 170                 175     


Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ser Ile Thr Gly 
            180                 185                 190         


Gly Gly Thr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        195                 200                 205             


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
    210                 215                 220                 


Lys Pro Glu Asp Thr Ala Val His Tyr Cys Asn Gly Tyr Arg Tyr Thr 
225                 230                 235                 240 


Tyr Ala Trp Gly Gln Gly Thr Gln Val Thr Gln Val Thr Val Ser Ser 
                245                 250                 255     


<210>  48
<211>  261
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-001/005 SEQ ID NO: 48

<400>  48

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg Asn Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Pro Glu Phe Ile 
        35                  40                  45              


Ala Gly Ile Asn Arg Ser Gly Ala Ile Thr Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Glu Thr Thr Trp Ser Ile Arg Arg Asp Asp Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val 
    130                 135                 140                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
145                 150                 155                 160 


Cys Glu Ala Ser Gly Arg Asp Phe Asn Asp Ala Ala Leu Gly Trp Ser 
                165                 170                 175     


Arg Gln Val Pro Gly Lys Ala Arg Glu Thr Val Ala Met Ile Thr Ser 
            180                 185                 190         


Gly Gly Val Arg Asn Tyr Ala Glu Thr Val Lys Asp Arg Phe Thr Ile 
        195                 200                 205             


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Asp Met Asn Asn Leu 
    210                 215                 220                 


Gln Pro Asp Asp Thr Gly Val Tyr Tyr Cys Lys Ala Asp Ser Phe Lys 
225                 230                 235                 240 


Gly Asp Tyr Asp Thr Ser Trp Tyr Leu Tyr Trp Gly Gln Gly Thr Gln 
                245                 250                 255     


Val Thr Val Ser Ser 
            260     


<210>  49
<211>  292
<212>  PRT
<213>  Artificial

<220>
<223>  KB AT-002/003_ABP SEQ ID NO: 49

<400>  49

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Asn Asn 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Tyr Ile Met Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Thr Arg Tyr Asn Ser Gly Leu Phe Ser Arg Asn Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu 
    130                 135                 140                 


Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
145                 150                 155                 160 


Ser Cys Ala Ala Ser Ala Leu Thr Phe Ser Ser Arg Ala Trp Ala Trp 
                165                 170                 175     


Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ser Ile Thr 
            180                 185                 190         


Gly Gly Gly Thr Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
        195                 200                 205             


Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
    210                 215                 220                 


Leu Lys Pro Glu Asp Thr Ala Val His Tyr Cys Asn Gly Tyr Arg Tyr 
225                 230                 235                 240 


Thr Tyr Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Arg 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            260                 265                 270         


Gln Gly Leu Ile Gly Asp Ile Ala Leu Pro Arg Trp Gly Ala Leu Trp 
        275                 280                 285             


Gly Asp Ser Val 
    290         


<210>  50
<211>  402
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-112 SEQ ID NO: 50

<400>  50

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg Asn Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Pro Glu Phe Ile 
        35                  40                  45              


Ala Gly Ile Asn Arg Ser Gly Ala Ile Thr Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Glu Thr Thr Trp Ser Ile Arg Arg Asp Asp Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Gln 
    130                 135                 140                 


Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser 
145                 150                 155                 160 


Cys Ala Ala Ser Gly Arg Thr Phe Arg Asn Tyr Val Met Gly Trp Phe 
                165                 170                 175     


Arg Gln Ala Pro Gly Lys Asp Pro Glu Phe Ile Ala Gly Ile Asn Arg 
            180                 185                 190         


Ser Gly Ala Ile Thr Tyr Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr 
        195                 200                 205             


Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser Leu Gln Met Asn Ser 
    210                 215                 220                 


Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Glu Thr 
225                 230                 235                 240 


Thr Trp Ser Ile Arg Arg Asp Asp Tyr Asp Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Gln Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Arg Thr Phe Asn Asn Asn Gly Met Gly Trp Phe Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Trp Ser Gly Gly Ser Thr 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Tyr Ile Met Ser Arg Asp Asn 
            340                 345                 350         


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Ala Arg Thr Arg Tyr Asn Ser Gly Leu 
    370                 375                 380                 


Phe Ser Arg Asn Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
385                 390                 395                 400 


Ser Ser 
        


<210>  51
<211>  395
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-113 SEQ ID NO: 51

<400>  51

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg Asn Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Pro Glu Phe Ile 
        35                  40                  45              


Ala Gly Ile Asn Arg Ser Gly Ala Ile Thr Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Glu Thr Thr Trp Ser Ile Arg Arg Asp Asp Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Gln 
    130                 135                 140                 


Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser 
145                 150                 155                 160 


Cys Ala Ala Ser Gly Arg Thr Phe Arg Asn Tyr Val Met Gly Trp Phe 
                165                 170                 175     


Arg Gln Ala Pro Gly Lys Asp Pro Glu Phe Ile Ala Gly Ile Asn Arg 
            180                 185                 190         


Ser Gly Ala Ile Thr Tyr Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr 
        195                 200                 205             


Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser Leu Gln Met Asn Ser 
    210                 215                 220                 


Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Glu Thr 
225                 230                 235                 240 


Thr Trp Ser Ile Arg Arg Asp Asp Tyr Asp Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Gln Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala 
    290                 295                 300                 


Leu Thr Phe Ser Ser Arg Ala Trp Ala Trp Tyr Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Gln Arg Glu Leu Val Ala Ser Ile Thr Gly Gly Gly Thr Thr Asn 
                325                 330                 335     


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
            340                 345                 350         


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
        355                 360                 365             


Ala Val His Tyr Cys Asn Gly Tyr Arg Tyr Thr Tyr Ala Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Gln Val Thr Val Ser Ser 
385                 390                 395 


<210>  52
<211>  400
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-115 SEQ ID NO: 52

<400>  52

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg Asn Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Pro Glu Phe Ile 
        35                  40                  45              


Ala Gly Ile Asn Arg Ser Gly Ala Ile Thr Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Glu Thr Thr Trp Ser Ile Arg Arg Asp Asp Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Gln 
    130                 135                 140                 


Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser 
145                 150                 155                 160 


Cys Ala Ala Ser Gly Arg Thr Phe Arg Asn Tyr Val Met Gly Trp Phe 
                165                 170                 175     


Arg Gln Ala Pro Gly Lys Asp Pro Glu Phe Ile Ala Gly Ile Asn Arg 
            180                 185                 190         


Ser Gly Ala Ile Thr Tyr Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr 
        195                 200                 205             


Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser Leu Gln Met Asn Ser 
    210                 215                 220                 


Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Glu Thr 
225                 230                 235                 240 


Thr Trp Ser Ile Arg Arg Asp Asp Tyr Asp Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Gln Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly 
    290                 295                 300                 


Arg Asp Phe Asn Asp Ala Ala Leu Gly Trp Ser Arg Gln Val Pro Gly 
305                 310                 315                 320 


Lys Ala Arg Glu Thr Val Ala Met Ile Thr Ser Gly Gly Val Arg Asn 
                325                 330                 335     


Tyr Ala Glu Thr Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala 
            340                 345                 350         


Lys Asn Thr Val Tyr Leu Asp Met Asn Asn Leu Gln Pro Asp Asp Thr 
        355                 360                 365             


Gly Val Tyr Tyr Cys Lys Ala Asp Ser Phe Lys Gly Asp Tyr Asp Thr 
    370                 375                 380                 


Ser Trp Tyr Leu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
385                 390                 395                 400 


<210>  53
<211>  535
<212>  PRT
<213>  Artificial

<220>
<223>  KB-AT-1123 SEQ ID NO: 53

<400>  53

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg Asn Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Pro Glu Phe Ile 
        35                  40                  45              


Ala Gly Ile Asn Arg Ser Gly Ala Ile Thr Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Glu Thr Thr Trp Ser Ile Arg Arg Asp Asp Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Gln 
    130                 135                 140                 


Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser 
145                 150                 155                 160 


Cys Ala Ala Ser Gly Arg Thr Phe Arg Asn Tyr Val Met Gly Trp Phe 
                165                 170                 175     


Arg Gln Ala Pro Gly Lys Asp Pro Glu Phe Ile Ala Gly Ile Asn Arg 
            180                 185                 190         


Ser Gly Ala Ile Thr Tyr Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr 
        195                 200                 205             


Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser Leu Gln Met Asn Ser 
    210                 215                 220                 


Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly Glu Thr 
225                 230                 235                 240 


Thr Trp Ser Ile Arg Arg Asp Asp Tyr Asp Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Gln Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly 
        275                 280                 285             


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
    290                 295                 300                 


Arg Thr Phe Asn Asn Asn Gly Met Gly Trp Phe Arg Gln Ala Pro Gly 
305                 310                 315                 320 


Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Trp Ser Gly Gly Ser Thr 
                325                 330                 335     


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Tyr Ile Met Ser Arg Asp Asn 
            340                 345                 350         


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
        355                 360                 365             


Thr Ala Val Tyr Tyr Cys Ala Ala Arg Thr Arg Tyr Asn Ser Gly Leu 
    370                 375                 380                 


Phe Ser Arg Asn Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
385                 390                 395                 400 


Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro 
            420                 425                 430         


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Leu Thr Phe Ser 
        435                 440                 445             


Ser Arg Ala Trp Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
    450                 455                 460                 


Leu Val Ala Ser Ile Thr Gly Gly Gly Thr Thr Asn Tyr Ala Asp Ser 
465                 470                 475                 480 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
                485                 490                 495     


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val His Tyr 
            500                 505                 510         


Cys Asn Gly Tyr Arg Tyr Thr Tyr Ala Trp Gly Gln Gly Thr Gln Val 
        515                 520                 525             


Thr Gln Val Thr Val Ser Ser 
    530                 535 


<210>  54
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  KB-FIBR-008 CDR1 SEQ ID NO: 54

<400>  54

Gly Gly Ser Met Thr Ser Gly Tyr Ala Ala 
1               5                   10  


<210>  55
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  KB-FIBR-008  CDR2 SEQ ID NO:  55

<400>  55

Ala Tyr Asp Gly Ser Thr Tyr Tyr Ser Pro Ser Leu Glu Ser 
1               5                   10                  


<210>  56
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  KB-FIBR-008 CDR3 SEQ ID NO:  56

<400>  56

Arg Leu Tyr Asn Gly Phe Glu His 
1               5               


<210>  57
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  KB-FIBR-008 SEQ ID NO:  57

<400>  57

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Met Thr Ser Gly 
            20                  25                  30          


Tyr Ala Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Ile Ile Ala Tyr Asp Gly Ser Thr Tyr Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Glu Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Gln Leu Ser Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Leu Tyr Asn Gly Phe Glu His Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  58
<211>  302
<212>  PRT
<213>  Artificial

<220>
<223>  KB-FIBR-008bv-ABP SEQ ID NO: 58

<400>  58

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Ser Arg Ser Gly His Arg Thr Asp Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Ser Asp Trp Ser Ile Ala Thr Thr Ala Thr Ser Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu 
    130                 135                 140                 


Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Asp Ser Leu Arg Leu 
145                 150                 155                 160 


Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Asn Tyr Ala Met Gly Trp 
                165                 170                 175     


Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val Ala Arg Ile Ser 
            180                 185                 190         


Arg Ser Gly His Arg Thr Asp Tyr Ala Asp Ser Ala Lys Gly Arg Phe 
        195                 200                 205             


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn 
    210                 215                 220                 


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg Ser 
225                 230                 235                 240 


Asp Trp Ser Ile Ala Thr Thr Ala Thr Ser Tyr Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Gln Val Thr Val Ser Ser Gly Arg Gly Gly Gly Ser Leu Thr 
            260                 265                 270         


Pro Arg Gly Val Arg Leu Gly Gly Gly Ser Gln Gly Leu Ile Gly Asp 
        275                 280                 285             


Ile Ala Leu Pro Arg Trp Gly Ala Leu Trp Gly Asp Ser Val 
    290                 295                 300         


<210>  59
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  KB-FIBR-009 CDR1 SEQ ID NO: 59

<400>  59

Gly Phe Thr Phe Asp Asp Tyr Ala Met Ser 
1               5                   10  


<210>  60
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  KB-FIBR-009 CDR2 SEQ ID NO: 60

<400>  60

Ile Ser Trp Asn Gly Lys Thr Thr Leu Tyr Ala Glu Ser Met Lys Gly 
1               5                   10                  15      


<210>  61
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  KB-FIBR-009 CDR3 SEQ ID NO: 61

<400>  61

Arg Gly Ser Gly Leu Phe Val Ser 
1               5               


<210>  62
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>   KB-FIBR-009 SEQ ID NO: 62

<400>  62

Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
1               5                   10                  15      


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Met 
            20                  25                  30          


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala 
        35                  40                  45              


Ile Ser Trp Asn Gly Lys Thr Thr Leu Tyr Ala Glu Ser Met Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys Ala Asp 
                85                  90                  95      


Arg Gly Ser Gly Leu Phe Val Ser Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  63
<211>  284
<212>  PRT
<213>  Artificial

<220>
<223>  KB-FIBR-009bv-ABP SEQ ID NO: 63

<400>  63

Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
1               5                   10                  15      


Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr Ala Met 
            20                  25                  30          


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala 
        35                  40                  45              


Ile Ser Trp Asn Gly Lys Thr Thr Leu Tyr Ala Glu Ser Met Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys Ala Asp 
                85                  90                  95      


Arg Gly Ser Gly Leu Phe Val Ser Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    130                 135                 140                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp 
145                 150                 155                 160 


Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Val Ser Ala Ile Ser Trp Asn Gly Lys Thr Thr Leu Tyr Ala Glu Ser 
            180                 185                 190         


Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
        195                 200                 205             


Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser 
    210                 215                 220                 


Cys Ala Asp Arg Gly Ser Gly Leu Phe Val Ser Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Gln Val Thr Val Ser Ser Gly Arg Gly Gly Gly Ser Leu Thr Pro Arg 
                245                 250                 255     


Gly Val Arg Leu Gly Gly Gly Ser Gln Gly Leu Ile Gly Asp Ile Ala 
            260                 265                 270         


Leu Pro Arg Trp Gly Ala Leu Trp Gly Asp Ser Val 
        275                 280                 


<210>  64
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  KB-FIBR-011 CDR1 SEQ ID NO: 64

<400>  64

Gly Phe Thr Phe Gly Ser Tyr Asp Met Asn 
1               5                   10  


<210>  65
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>   KB-FIBR-011 CDR2 SEQ ID NO: 65

<400>  65

Ile Ser Tyr Ser Thr Trp Tyr Ala Asp Ser Met Glu Gly 
1               5                   10              


<210>  66
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  KB-FIBR-011 CDR3 SEQ ID NO: 66

<400>  66

Asp Leu Val Gly Leu Val Gly Leu Glu Gly Gly Tyr 
1               5                   10          


<210>  67
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  KB-FIBR-011SEQ ID NO: 67

<400>  67

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Tyr 
            20                  25                  30          


Asp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Tyr Ser Thr Trp Tyr Ala Asp Ser Met Glu Gly Arg 
    50                  55                  60                  


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met 
65                  70                  75                  80  


Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Thr Asp 
                85                  90                  95      


Leu Val Gly Leu Val Gly Leu Glu Gly Gly Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  68
<211>  290
<212>  PRT
<213>  Artificial

<220>
<223>  KB-FIBR-011bv_ABP SEQ ID NO: 68

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Tyr 
            20                  25                  30          


Asp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Tyr Ser Thr Trp Tyr Ala Asp Ser Met Glu Gly Arg 
    50                  55                  60                  


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met 
65                  70                  75                  80  


Thr Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Thr Thr Asp 
                85                  90                  95      


Leu Val Gly Leu Val Gly Leu Glu Gly Gly Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
145                 150                 155                 160 


Phe Thr Phe Gly Ser Tyr Asp Met Asn Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Pro Glu Trp Val Ser Thr Ile Ser Tyr Ser Thr Trp Tyr Ala 
            180                 185                 190         


Asp Ser Met Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
        195                 200                 205             


Thr Leu Tyr Leu Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Thr Thr Asp Leu Val Gly Leu Val Gly Leu Glu Gly Gly 
225                 230                 235                 240 


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Arg Gly Gly 
                245                 250                 255     


Gly Ser Leu Thr Pro Arg Gly Val Arg Leu Gly Gly Gly Ser Gln Gly 
            260                 265                 270         


Leu Ile Gly Asp Ile Ala Leu Pro Arg Trp Gly Ala Leu Trp Gly Asp 
        275                 280                 285             


Ser Val 
    290 


<210>  69
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  KB-FIBR-022  CDR1 SEQ ID NO: 69

<400>  69

Gly Phe Thr Phe Asp Asp Tyr Ala Met Ser 
1               5                   10  


<210>  70
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  KB-FIBR-022 CDR2 SEQ ID NO: 70

<400>  70

Ile Asn Ser Gly Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  71
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  KB-FIBR-022 CDR3 SEQ ID NO: 71

<400>  71

Lys Ile Trp Thr Gln Phe Gly Tyr 
1               5               


<210>  72
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  KB-FIBR-022 SEQ ID NO: 72

<400>  72

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Ser Gly Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Lys Ile Trp Thr Gln Phe Gly Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  73
<211>  288
<212>  PRT
<213>  Artificial

<220>
<223>  KB-FIBR-022bv_ABP SEQ ID NO: 73

<400>  73

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Ser Gly Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Lys Ile Trp Thr Gln Phe Gly Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Thr Phe Asp Asp Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Gly Leu Glu Trp Val Ser Ala Ile Asn Ser Gly Gly Gly Ser Thr Ser 
            180                 185                 190         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp 
        195                 200                 205             


Lys Lys Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Val Lys Ile Trp Thr Gln Phe Gly Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Arg Gly Gly Gly Ser 
                245                 250                 255     


Leu Thr Pro Arg Gly Val Arg Leu Gly Gly Gly Ser Gln Gly Leu Ile 
            260                 265                 270         


Gly Asp Ile Ala Leu Pro Arg Trp Gly Ala Leu Trp Gly Asp Ser Val 
        275                 280                 285             


<210>  74
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  KB-FIBR-048  CDR1 SEQ ID NO: 74

<400>  74

Lys Gly Ile Phe Ala Phe Asn Gly Met Gly 
1               5                   10  


<210>  75
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  KB-FIBR-048 CDR2 SEQ ID NO: 75

<400>  75

Ile Met Gln Pro Asn Gly Arg Thr Ile Tyr Lys Asp Thr Val Lys Gly 
1               5                   10                  15      


<210>  76
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  KB-FIBR-048 CDR3 SEQ ID NO: 76

<400>  76

Trp Val Asn Arg Thr Asn Asp Met Tyr 
1               5                   


<210>  77
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  KB-FIBR-048 SEQ ID NO: 77

<400>  77

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Lys Gly Ile Phe Ala Phe Asn 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Lys Met Gln Pro Asn Gly Arg Thr Ile Tyr Lys Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Gln Lys Ala Thr Val Asp Leu 
65                  70                  75                  80  


Leu Met Lys Ser Leu Gln Pro Glu Asp Thr Ala Asp Tyr Tyr Cys Gly 
                85                  90                  95      


Ala Trp Val Asn Arg Thr Asn Asp Met Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  78
<211>  288
<212>  PRT
<213>  Artificial

<220>
<223>  KB-FIBR-048bv_ABP SEQ ID NO: 78

<400>  78

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Lys Gly Ile Phe Ala Phe Asn 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Lys Met Gln Pro Asn Gly Arg Thr Ile Tyr Lys Asp Thr Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ile Gln Lys Ala Thr Val Asp Leu 
65                  70                  75                  80  


Leu Met Lys Ser Leu Gln Pro Glu Asp Thr Ala Asp Tyr Tyr Cys Gly 
                85                  90                  95      


Ala Trp Val Asn Arg Thr Asn Asp Met Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly Ser 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Lys Gly 
145                 150                 155                 160 


Ile Phe Ala Phe Asn Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Glu Arg Glu Leu Val Ala Lys Met Gln Pro Asn Gly Arg Thr Ile Tyr 
            180                 185                 190         


Lys Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ile Gln Lys 
        195                 200                 205             


Ala Thr Val Asp Leu Leu Met Lys Ser Leu Gln Pro Glu Asp Thr Ala 
    210                 215                 220                 


Asp Tyr Tyr Cys Gly Ala Trp Val Asn Arg Thr Asn Asp Met Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Arg Gly Gly Gly Ser 
                245                 250                 255     


Leu Thr Pro Arg Gly Val Arg Leu Gly Gly Gly Ser Gln Gly Leu Ile 
            260                 265                 270         


Gly Asp Ile Ala Leu Pro Arg Trp Gly Ala Leu Trp Gly Asp Ser Val 
        275                 280                 285             


<210>  79
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  KB-PAI1-002 CDR1 SEQ ID NO: 79

<400>  79

Met Ser Ser Phe Gly Met Tyr His Met Gly 
1               5                   10  


<210>  80
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  KB-PAI1-002 CDR2 SEQ ID NO: 80

<400>  80

Ile Gly Pro Ser Gly Asn Thr Tyr Tyr Leu Asp Ser Val Lys Gly 
1               5                   10                  15  


<210>  81
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  KB-PAI1-002 CDR3 SEQ ID NO: 81

<400>  81

Ser Arg Lys Val Val Ser Leu Ala Val Asp Tyr 
1               5                   10      


<210>  82
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  KB-PAI1-002 SEQ ID NO: 82

<400>  82

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Met Ser Ser Phe Gly Met Tyr 
            20                  25                  30          


His Met Gly Trp Tyr Arg Gln Ala Pro Gly Ser Gln Arg Lys Met Val 
        35                  40                  45              


Ala Trp Ile Gly Pro Ser Gly Asn Thr Tyr Tyr Leu Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Ser Arg Lys Val Val Ser Leu Ala Val Asp Tyr Arg Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  83
<211>  292
<212>  PRT
<213>  Artificial

<220>
<223>  KB-PAI1-002bv_ABP SEQ ID NO: 83

<400>  83

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Met Ser Ser Phe Gly Met Tyr 
            20                  25                  30          


His Met Gly Trp Tyr Arg Gln Ala Pro Gly Ser Gln Arg Lys Met Val 
        35                  40                  45              


Ala Trp Ile Gly Pro Ser Gly Asn Thr Tyr Tyr Leu Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Ser Arg Lys Val Val Ser Leu Ala Val Asp Tyr Arg Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    130                 135                 140                 


Gly Leu Val Gln Thr Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser 
145                 150                 155                 160 


Met Ser Ser Phe Gly Met Tyr His Met Gly Trp Tyr Arg Gln Ala Pro 
                165                 170                 175     


Gly Ser Gln Arg Lys Met Val Ala Trp Ile Gly Pro Ser Gly Asn Thr 
            180                 185                 190         


Tyr Tyr Leu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Lys Ser Arg Lys Val Val Ser Leu Ala 
225                 230                 235                 240 


Val Asp Tyr Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Arg 
                245                 250                 255     


Gly Gly Gly Ser Leu Thr Pro Arg Gly Val Arg Leu Gly Gly Gly Ser 
            260                 265                 270         


Gln Gly Leu Ile Gly Asp Ile Ala Leu Pro Arg Trp Gly Ala Leu Trp 
        275                 280                 285             


Gly Asp Ser Val 
    290         


<210>  84
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  KB-PAI1-006 CDR1 SEQ ID NO: 84

<400>  84

Gly Asp Arg Leu Ser Ala Tyr Ala Met Gly 
1               5                   10  


<210>  85
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  KB-PAI1-006 CDR2 SEQ ID NO: 85

<400>  85

Ile Ser Arg Thr Ser Gly Arg Thr Tyr Tyr Ala Gly Ser Val Lys Gly 
1               5                   10                  15      


<210>  86
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  KB-PAI1-006 CDR3 SEQ ID NO: 86

<400>  86

Arg Tyr Gly Arg Tyr Asp Val Ala Arg Met Ser Arg Val Asp Tyr 
1               5                   10                  15  


<210>  87
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  KB-PAI1-006 SEQ ID NO: 87

<400>  87

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Arg Leu Ser Ala Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Arg Thr Ser Gly Arg Thr Tyr Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Tyr Gly Arg Tyr Asp Val Ala Arg Met Ser Arg Val Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  88
<211>  302
<212>  PRT
<213>  Artificial

<220>
<223>  KB-PAI1-006bv_ABP SEQ ID NO: 88

<400>  88

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Arg Leu Ser Ala Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Ser Arg Thr Ser Gly Arg Thr Tyr Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Tyr Gly Arg Tyr Asp Val Ala Arg Met Ser Arg Val Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu 
    130                 135                 140                 


Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Glu Ser Leu Arg Leu 
145                 150                 155                 160 


Ser Cys Ala Ala Ser Gly Asp Arg Leu Ser Ala Tyr Ala Met Gly Trp 
                165                 170                 175     


Phe Arg Gln Gly Pro Gly Lys Asp Arg Glu Phe Val Ser Ala Ile Ser 
            180                 185                 190         


Arg Thr Ser Gly Arg Thr Tyr Tyr Ala Gly Ser Val Lys Gly Arg Phe 
        195                 200                 205             


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn 
    210                 215                 220                 


Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg Tyr 
225                 230                 235                 240 


Gly Arg Tyr Asp Val Ala Arg Met Ser Arg Val Asp Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Gln Val Thr Val Ser Ser Gly Arg Gly Gly Gly Ser Leu Thr 
            260                 265                 270         


Pro Arg Gly Val Arg Leu Gly Gly Gly Ser Gln Gly Leu Ile Gly Asp 
        275                 280                 285             


Ile Ala Leu Pro Arg Trp Gly Ala Leu Trp Gly Asp Ser Val 
    290                 295                 300         


<210>  89
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  KB-PAI1-007  CDR1 SEQ ID NO:  89

<400>  89

Gly Phe Thr Phe Ser Ser His Trp Met Asn 
1               5                   10  


<210>  90
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  KB-PAI1-007 CDR2 SEQ ID NO: 90

<400>  90

Ile Ser Gly Gly Gly Phe Thr Thr Tyr Tyr Ala Asp Phe Val Lys Gly 
1               5                   10                  15      


<210>  91
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  KB-PAI1-007 CDR3 SEQ ID NO: 91

<400>  91

Gly Pro Trp Gln Asp Val Asp Ala 
1               5               


<210>  92
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  KB-PAI1-007 SEQ ID NO: 92

<400>  92

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Ile 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Phe Thr Thr Tyr Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Pro Trp Gln Asp Val Asp Ala Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  93
<211>  288
<212>  PRT
<213>  Artificial

<220>
<223>  KB-PAI1-007bv_ABP SEQ ID NO: 93

<400>  93

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Ile 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Phe Thr Thr Tyr Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Pro Trp Gln Asp Val Asp Ala Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
145                 150                 155                 160 


Thr Phe Ser Ser His Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Gly Leu Gln Trp Ile Ser Thr Ile Ser Gly Gly Gly Phe Thr Thr Tyr 
            180                 185                 190         


Tyr Ala Asp Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        195                 200                 205             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Lys Gly Pro Trp Gln Asp Val Asp Ala Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Arg Gly Gly Gly Ser 
                245                 250                 255     


Leu Thr Pro Arg Gly Val Arg Leu Gly Gly Gly Ser Gln Gly Leu Ile 
            260                 265                 270         


Gly Asp Ile Ala Leu Pro Arg Trp Gly Ala Leu Trp Gly Asp Ser Val 
        275                 280                 285             


<210>  94
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  thrombin-cleavage site SEQ ID NO: 94

<400>  94

Leu Thr Pro Arg Gly Val Arg Leu 
1               5               


