                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
 
<120>  Anti-HLA-G antibodies and use thereof

<130>  P33980-WO

<150>  EP16199620.2
<151>  2016-11-18

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  rat

<400>  1

Ser Tyr Asp Met His 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  rat

<400>  2

Trp Ile Tyr Pro Gly Asn Gly Asn Thr Lys Tyr Asn Gln Lys Phe Asn 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  12
<212>  PRT
<213>  rat

<400>  3

Pro Thr Val Ala Thr Arg Tyr Asn Trp Phe Ala Tyr 
1               5                   10          


<210>  4
<211>  10
<212>  PRT
<213>  rat

<400>  4

Ser Ala Ser Ser Ser Val Asn Tyr Met His 
1               5                   10  


<210>  5
<211>  7
<212>  PRT
<213>  rat

<400>  5

Leu Thr Ser Asn Leu Ala Ser 
1               5           


<210>  6
<211>  10
<212>  PRT
<213>  rat

<400>  6

Gln Gln Trp Ser Ser Asn Leu Pro Ile Thr 
1               5                   10  


<210>  7
<211>  121
<212>  PRT
<213>  rat

<400>  7

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Ser Tyr 
            20                  25                  30          


Asp Met His Trp Ile Lys Gln Gln Pro Gly Asn Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Gly Asn Thr Lys Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Asn Gly Lys Ala Ser Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Pro Thr Val Ala Thr Arg Tyr Asn Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  8
<211>  107
<212>  PRT
<213>  rat

<400>  8

Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Thr Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Leu Pro Ile 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  9
<211>  5
<212>  PRT
<213>  rat

<400>  9

Thr Tyr Ser Val Ser 
1               5   


<210>  10
<211>  16
<212>  PRT
<213>  rat

<400>  10

Ala Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  11
<211>  12
<212>  PRT
<213>  rat

<400>  11

Met Asn Asn Lys Phe Gly Tyr Trp Tyr Phe Asp Leu 
1               5                   10          


<210>  12
<211>  11
<212>  PRT
<213>  rat

<400>  12

Arg Ala Ser Glu Thr Val Ser Thr Met Leu His 
1               5                   10      


<210>  13
<211>  7
<212>  PRT
<213>  rat

<400>  13

Leu Ala Ser His Leu Glu Ser 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  rat

<400>  14

Gln Gln Thr Trp Asn Asp Pro Leu Thr 
1               5                   


<210>  15
<211>  120
<212>  PRT
<213>  rat

<400>  15

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Ser Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Arg Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Leu Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Arg Ala Met Tyr Phe Cys Val 
                85                  90                  95      


Arg Met Asn Asn Lys Phe Gly Tyr Trp Tyr Phe Asp Leu Trp Gly Pro 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  16
<211>  106
<212>  PRT
<213>  rat

<400>  16

Asp Thr Val Leu Thr Gln Ser Pro Thr Leu Ala Val Ser Pro Gly Glu 
1               5                   10                  15      


Lys Ile Thr Ile Ser Cys Arg Ala Ser Glu Thr Val Ser Thr Met Leu 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Gln Pro Lys Leu Leu Ile Ser 
        35                  40                  45              


Leu Ala Ser His Leu Glu Ser Gly Val Pro Ala Arg Phe Thr Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Glu Ala Asp 
65                  70                  75                  80  


Asp Thr Ala Thr Tyr Tyr Cys Gln Gln Thr Trp Asn Asp Pro Leu Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  17
<211>  314
<212>  PRT
<213>  homo sapiens

<400>  17

Gly Ser His Ser Met Arg Tyr Phe Ser Ala Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Met Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ser Ala Cys Pro Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu Glu Thr 
    50                  55                  60                  


Arg Asn Thr Lys Ala His Ala Gln Thr Asp Arg Met Asn Leu Gln Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Ser Ser His Thr Leu Gln 
                85                  90                  95      


Trp Met Ile Gly Cys Asp Leu Gly Ser Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Glu Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Leu Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Ser Lys 
    130                 135                 140                 


Arg Lys Cys Glu Ala Ala Asn Val Ala Glu Gln Arg Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu His Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Met Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Val Phe Asp Tyr Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Ile Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Val Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Met Leu 
            260                 265                 270         


Arg Trp Lys Gln Ser Ser Leu Pro Thr Ile Pro Ile Met Gly Ile Val 
        275                 280                 285             


Ala Gly Leu Val Val Leu Ala Ala Val Val Thr Gly Ala Ala Val Ala 
    290                 295                 300                 


Ala Val Leu Trp Arg Lys Lys Ser Ser Asp 
305                 310                 


<210>  18
<211>  274
<212>  PRT
<213>  homo sapiens

<400>  18

Gly Ser His Ser Met Arg Tyr Phe Ser Ala Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Met Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ser Ala Cys Pro Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu Glu Thr 
    50                  55                  60                  


Arg Asn Thr Lys Ala His Ala Gln Thr Asp Arg Met Asn Leu Gln Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Ser Ser His Thr Leu Gln 
                85                  90                  95      


Trp Met Ile Gly Cys Asp Leu Gly Ser Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Glu Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Leu Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Ser Lys 
    130                 135                 140                 


Arg Lys Cys Glu Ala Ala Asn Val Ala Glu Gln Arg Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu His Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Met Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Val Phe Asp Tyr Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Ile Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Val Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Met Leu 
            260                 265                 270         


Arg Trp 
        


<210>  19
<211>  99
<212>  PRT
<213>  homo sapiens

<400>  19

Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu 
1               5                   10                  15      


Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro 
            20                  25                  30          


Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys 
        35                  40                  45              


Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu 
    50                  55                  60                  


Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys 
65                  70                  75                  80  


Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp 
                85                  90                  95      


Arg Asp Met 
            


<210>  20
<211>  275
<212>  PRT
<213>  Artificial

<220>
<223>  modified human HLA-G (wherein the HLA-G specific amino acids have
       been replaced by HLA-A consensus amino acids  (= degrafted HLA-G)
       ECD

<400>  20

Gly Ser His Ser Met Arg Tyr Phe Ser Ala Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Met Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Glu Glu Thr 
    50                  55                  60                  


Arg Asn Thr Lys Ala His Ala Gln Thr Asp Arg Val Asn Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Trp Met Ile Gly Cys Asp Val Gly Ser Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Glu Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Leu Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Ser Lys 
    130                 135                 140                 


Arg Lys Cys Glu Ala Ala His Val Ala Glu Gln Arg Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Val Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Lys 
        275 


<210>  21
<211>  341
<212>  PRT
<213>  homo sapiens

<400>  21

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr 
    50                  55                  60                  


Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys 
    130                 135                 140                 


His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro Ser Ser Gln Pro Thr Ile Pro Ile Val Gly Ile Ile 
        275                 280                 285             


Ala Gly Leu Val Leu Phe Gly Ala Val Ile Thr Gly Ala Val Val Ala 
    290                 295                 300                 


Ala Val Met Trp Arg Arg Lys Ser Ser Asp Arg Lys Gly Gly Ser Tyr 
305                 310                 315                 320 


Ser Gln Ala Ala Ser Ser Asp Ser Ala Gln Gly Ser Asp Val Ser Leu 
                325                 330                 335     


Thr Ala Cys Lys Val 
            340     


<210>  22
<211>  275
<212>  PRT
<213>  homo sapiens

<400>  22

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr 
    50                  55                  60                  


Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys 
    130                 135                 140                 


His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu 
        275 


<210>  23
<211>  275
<212>  PRT
<213>  mus musculus

<400>  23

Gly Pro His Ser Leu Arg Tyr Phe Val Thr Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Leu Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Asp Asn Pro Arg Phe Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Met Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu Gln Thr 
    50                  55                  60                  


Gln Arg Ala Lys Ser Asp Glu Gln Trp Phe Arg Val Ser Leu Arg Thr 
65                  70                  75                  80  


Ala Gln Arg Cys Tyr Asn Gln Ser Lys Gly Gly Ser His Thr Phe Gln 
                85                  90                  95      


Arg Met Phe Gly Cys Asp Val Gly Ser Asp Trp Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Gln Gln Phe Ala Tyr Asp Gly Arg Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Lys Thr Trp Thr Ala Ala Asp Thr Ala Ala Leu Ile Thr Arg 
    130                 135                 140                 


Arg Lys Trp Glu Gln Ala Gly Asp Ala Glu Tyr Tyr Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Leu Gly Asn 
                165                 170                 175     


Glu Thr Leu Leu Arg Thr Asp Ser Pro Lys Ala His Val Thr Tyr His 
            180                 185                 190         


Pro Arg Ser Gln Val Asp Val Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Asp Leu 
    210                 215                 220                 


Thr Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Leu Gly Lys Glu Gln Asn 
                245                 250                 255     


Tyr Thr Cys His Val His His Lys Gly Leu Pro Glu Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Lys 
        275 


<210>  24
<211>  274
<212>  PRT
<213>  rat

<400>  24

Gly Ser His Ser Leu Arg Tyr Phe Tyr Thr Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Leu Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Glu 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Glu Asn Pro Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Arg Trp Met Glu Arg Glu Gly Pro Glu Tyr Trp Glu Gln Gln Thr 
    50                  55                  60                  


Arg Ile Ala Lys Glu Trp Glu Gln Ile Tyr Arg Val Asp Leu Arg Thr 
65                  70                  75                  80  


Leu Arg Gly Cys Tyr Asn Gln Ser Glu Gly Gly Ser His Thr Ile Gln 
                85                  90                  95      


Glu Met Tyr Gly Cys Asp Val Gly Ser Asp Gly Ser Leu Leu Arg Gly 
            100                 105                 110         


Tyr Arg Gln Asp Ala Tyr Asp Gly Arg Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Lys Thr Trp Thr Ala Ala Asp Phe Ala Ala Gln Ile Thr Arg 
    130                 135                 140                 


Asn Lys Trp Glu Arg Ala Arg Tyr Ala Glu Arg Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Ser Arg Tyr Leu Glu Leu Gly Lys 
                165                 170                 175     


Glu Thr Leu Leu Arg Ser Asp Pro Pro Glu Ala His Val Thr Leu His 
            180                 185                 190         


Pro Arg Pro Glu Gly Asp Val Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Asp Leu 
    210                 215                 220                 


Thr Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ser Val Val Val Pro Leu Gly Lys Glu Gln Asn 
                245                 250                 255     


Tyr Thr Cys Arg Val Glu His Glu Gly Leu Pro Lys Pro Leu Ser Gln 
            260                 265                 270         


Arg Trp 
        


<210>  25
<211>  440
<212>  PRT
<213>  homo sapiens

<400>  25

Arg Ile Ile Pro Arg His Leu Gln Leu Gly Cys Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln 
            20                  25                  30          


Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn 
        35                  40                  45              


Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu 
    50                  55                  60                  


Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe 
65                  70                  75                  80  


Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro 
                85                  90                  95      


Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser 
            100                 105                 110         


Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Ser His Ser Met Arg Tyr Phe Ser Ala Ala Val Ser Arg Pro Gly Arg 
145                 150                 155                 160 


Gly Glu Pro Arg Phe Ile Ala Met Gly Tyr Val Asp Asp Thr Gln Phe 
                165                 170                 175     


Val Arg Phe Asp Ser Asp Ser Ala Cys Pro Arg Met Glu Pro Arg Ala 
            180                 185                 190         


Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu Glu Thr Arg 
        195                 200                 205             


Asn Thr Lys Ala His Ala Gln Thr Asp Arg Met Asn Leu Gln Thr Leu 
    210                 215                 220                 


Arg Gly Cys Tyr Asn Gln Ser Glu Ala Ser Ser His Thr Leu Gln Trp 
225                 230                 235                 240 


Met Ile Gly Cys Asp Leu Gly Ser Asp Gly Arg Leu Leu Arg Gly Tyr 
                245                 250                 255     


Glu Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Leu Ala Leu Asn Glu Asp 
            260                 265                 270         


Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Ser Lys Arg 
        275                 280                 285             


Lys Cys Glu Ala Ala Asn Val Ala Glu Gln Arg Arg Ala Tyr Leu Glu 
    290                 295                 300                 


Gly Thr Cys Val Glu Trp Leu His Arg Tyr Leu Glu Asn Gly Lys Glu 
305                 310                 315                 320 


Met Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His Pro 
                325                 330                 335     


Val Phe Asp Tyr Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 
            340                 345                 350         


Pro Ala Glu Ile Ile Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr 
        355                 360                 365             


Gln Asp Val Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe 
    370                 375                 380                 


Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr 
385                 390                 395                 400 


Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Met Leu Arg 
                405                 410                 415     


Trp Gly Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp 
            420                 425                 430         


His Glu His His His His His His 
        435                 440 


<210>  26
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  exemplary modified human HLA-G 2M MHC class I complex (wherein 
       the HLA-G specific amino acids have been replaced by HLA-A 
       consensus amino acids  (= degrafted HLA-G)

<400>  26

Arg Ile Ile Pro Arg His Leu Gln Leu Gly Cys Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln 
            20                  25                  30          


Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn 
        35                  40                  45              


Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu 
    50                  55                  60                  


Lys Asn Gly Glu Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe 
65                  70                  75                  80  


Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro 
                85                  90                  95      


Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser 
            100                 105                 110         


Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Ser His Ser Met Arg Tyr Phe Ser Ala Ala Val Ser Arg Pro Gly Arg 
145                 150                 155                 160 


Gly Glu Pro Arg Phe Ile Ala Met Gly Tyr Val Asp Asp Thr Gln Phe 
                165                 170                 175     


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Met Glu Pro Arg Ala 
            180                 185                 190         


Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Glu Glu Thr Arg 
        195                 200                 205             


Asn Thr Lys Ala His Ala Gln Thr Asp Arg Val Asn Leu Gly Thr Leu 
    210                 215                 220                 


Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Trp 
225                 230                 235                 240 


Met Ile Gly Cys Asp Val Gly Ser Asp Gly Arg Leu Leu Arg Gly Tyr 
                245                 250                 255     


Glu Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Leu Ala Leu Asn Glu Asp 
            260                 265                 270         


Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Ser Lys Arg 
        275                 280                 285             


Lys Cys Glu Ala Ala His Val Ala Glu Gln Arg Arg Ala Tyr Leu Glu 
    290                 295                 300                 


Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
305                 310                 315                 320 


Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His Pro 
                325                 330                 335     


Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 
            340                 345                 350         


Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr 
        355                 360                 365             


Gln Asp Val Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe 
    370                 375                 380                 


Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr 
385                 390                 395                 400 


Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Thr Leu Arg 
                405                 410                 415     


Trp Lys Gly Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
            420                 425                 430         


Trp His Glu His His His His His His 
        435                 440     


<210>  27
<211>  441
<212>  PRT
<213>  mus musculus

<400>  27

Thr Tyr Gln Arg Thr Arg Ala Leu Val Gly Cys Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Lys Thr Pro Gln Ile Gln 
            20                  25                  30          


Val Tyr Ser Arg His Pro Pro Glu Asn Gly Lys Pro Asn Ile Leu Asn 
        35                  40                  45              


Cys Tyr Val Thr Gln Phe His Pro Pro His Ile Glu Ile Gln Met Leu 
    50                  55                  60                  


Lys Asn Gly Lys Lys Ile Pro Lys Val Glu Met Ser Asp Met Ser Phe 
65                  70                  75                  80  


Ser Lys Asp Trp Ser Phe Tyr Ile Leu Ala His Thr Glu Phe Thr Pro 
                85                  90                  95      


Thr Glu Thr Asp Thr Tyr Ala Cys Arg Val Lys His Asp Ser Met Ala 
            100                 105                 110         


Glu Pro Lys Thr Val Tyr Trp Asp Arg Asp Met Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Pro His Ser Leu Arg Tyr Phe Val Thr Ala Val Ser Arg Pro Gly Leu 
145                 150                 155                 160 


Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln Phe 
                165                 170                 175     


Val Arg Phe Asp Ser Asp Ala Asp Asn Pro Arg Phe Glu Pro Arg Ala 
            180                 185                 190         


Pro Trp Met Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu Gln Thr Gln 
        195                 200                 205             


Arg Ala Lys Ser Asp Glu Gln Trp Phe Arg Val Ser Leu Arg Thr Ala 
    210                 215                 220                 


Gln Arg Cys Tyr Asn Gln Ser Lys Gly Gly Ser His Thr Phe Gln Arg 
225                 230                 235                 240 


Met Phe Gly Cys Asp Val Gly Ser Asp Trp Arg Leu Leu Arg Gly Tyr 
                245                 250                 255     


Gln Gln Phe Ala Tyr Asp Gly Arg Asp Tyr Ile Ala Leu Asn Glu Asp 
            260                 265                 270         


Leu Lys Thr Trp Thr Ala Ala Asp Thr Ala Ala Leu Ile Thr Arg Arg 
        275                 280                 285             


Lys Trp Glu Gln Ala Gly Asp Ala Glu Tyr Tyr Arg Ala Tyr Leu Glu 
    290                 295                 300                 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Leu Gly Asn Glu 
305                 310                 315                 320 


Thr Leu Leu Arg Thr Asp Ser Pro Lys Ala His Val Thr Tyr His Pro 
                325                 330                 335     


Arg Ser Gln Val Asp Val Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 
            340                 345                 350         


Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Asp Leu Thr 
        355                 360                 365             


Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe 
    370                 375                 380                 


Gln Lys Trp Ala Ala Val Val Val Pro Leu Gly Lys Glu Gln Asn Tyr 
385                 390                 395                 400 


Thr Cys His Val His His Lys Gly Leu Pro Glu Pro Leu Thr Leu Arg 
                405                 410                 415     


Trp Lys Gly Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
            420                 425                 430         


Trp His Glu His His His His His His 
        435                 440     


<210>  28
<211>  441
<212>  PRT
<213>  Artificial

<220>
<223>  exemplary human HLA-G/ mouse H2Kd 2M MHC class I complex wherein
       the positions specific for human HLA-G are grafted onto the mouse
       H2Kd framework

<400>  28

Thr Tyr Gln Arg Thr Arg Ala Leu Val Gly Cys Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Lys Thr Pro Gln Ile Gln 
            20                  25                  30          


Val Tyr Ser Arg His Pro Pro Glu Asn Gly Lys Pro Asn Ile Leu Asn 
        35                  40                  45              


Cys Tyr Val Thr Gln Phe His Pro Pro His Ile Glu Ile Gln Met Leu 
    50                  55                  60                  


Lys Asn Gly Lys Lys Ile Pro Lys Val Glu Met Ser Asp Met Ser Phe 
65                  70                  75                  80  


Ser Lys Asp Trp Ser Phe Tyr Ile Leu Ala His Thr Glu Phe Thr Pro 
                85                  90                  95      


Thr Glu Thr Asp Thr Tyr Ala Cys Arg Val Lys His Asp Ser Met Ala 
            100                 105                 110         


Glu Pro Lys Thr Val Tyr Trp Asp Arg Asp Met Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Pro His Ser Leu Arg Tyr Phe Val Thr Ala Val Ser Arg Pro Gly Leu 
145                 150                 155                 160 


Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln Phe 
                165                 170                 175     


Val Arg Phe Asp Ser Asp Ser Ala Ser Pro Arg Phe Glu Pro Arg Ala 
            180                 185                 190         


Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu Gln Thr Gln 
        195                 200                 205             


Arg Ala Lys Ser Asp Glu Gln Trp Phe Arg Met Ser Leu Gln Thr Ala 
    210                 215                 220                 


Arg Gly Cys Tyr Asn Gln Ser Glu Ala Ser Ser His Thr Phe Gln Arg 
225                 230                 235                 240 


Met Phe Gly Cys Asp Leu Gly Ser Asp Gly Arg Leu Leu Arg Gly Tyr 
                245                 250                 255     


Gln Gln Phe Ala Tyr Asp Gly Arg Asp Tyr Ile Ala Leu Asn Glu Asp 
            260                 265                 270         


Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Leu Ile Thr Lys Arg 
        275                 280                 285             


Lys Trp Glu Ala Ala Asn Asp Ala Glu Tyr Tyr Arg Ala Tyr Leu Glu 
    290                 295                 300                 


Gly Glu Cys Val Glu Trp Leu His Arg Tyr Leu Glu Asn Gly Lys Glu 
305                 310                 315                 320 


Met Leu Gln Arg Thr Asp Ser Pro Lys Ala His Val Thr His His Pro 
                325                 330                 335     


Val Phe Asp Tyr Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 
            340                 345                 350         


Pro Ala Glu Ile Ile Leu Thr Trp Gln Leu Asn Gly Glu Asp Leu Thr 
        355                 360                 365             


Gln Asp Val Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe 
    370                 375                 380                 


Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Lys Glu Gln Asn Tyr 
385                 390                 395                 400 


Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Met Leu Arg 
                405                 410                 415     


Trp Lys Gly Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
            420                 425                 430         


Trp His Glu His His His His His His 
        435                 440     


<210>  29
<211>  440
<212>  PRT
<213>  rat

<400>  29

Ala Gln Phe Ser Ala Ser Ala Ser Arg Gly Cys Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Lys Thr Pro Gln Ile Gln 
            20                  25                  30          


Val Tyr Ser Arg His Pro Pro Glu Asn Gly Lys Pro Asn Phe Leu Asn 
        35                  40                  45              


Cys Tyr Val Ser Gln Phe His Pro Pro Gln Ile Glu Ile Glu Leu Leu 
    50                  55                  60                  


Lys Asn Gly Lys Lys Ile Pro Asn Ile Glu Met Ser Asp Leu Ser Phe 
65                  70                  75                  80  


Ser Lys Asp Trp Ser Phe Tyr Ile Leu Ala His Thr Glu Phe Thr Pro 
                85                  90                  95      


Thr Glu Thr Asp Val Tyr Ala Cys Arg Val Lys His Val Thr Leu Lys 
            100                 105                 110         


Glu Pro Lys Thr Val Thr Trp Asp Arg Asp Met Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Ser His Ser Leu Arg Tyr Phe Tyr Thr Ala Val Ser Arg Pro Gly Leu 
145                 150                 155                 160 


Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Glu Phe 
                165                 170                 175     


Val Arg Phe Asp Ser Asp Ala Glu Asn Pro Arg Met Glu Pro Arg Ala 
            180                 185                 190         


Arg Trp Met Glu Arg Glu Gly Pro Glu Tyr Trp Glu Gln Gln Thr Arg 
        195                 200                 205             


Ile Ala Lys Glu Trp Glu Gln Ile Tyr Arg Val Asp Leu Arg Thr Leu 
    210                 215                 220                 


Arg Gly Cys Tyr Asn Gln Ser Glu Gly Gly Ser His Thr Ile Gln Glu 
225                 230                 235                 240 


Met Tyr Gly Cys Asp Val Gly Ser Asp Gly Ser Leu Leu Arg Gly Tyr 
                245                 250                 255     


Arg Gln Asp Ala Tyr Asp Gly Arg Asp Tyr Ile Ala Leu Asn Glu Asp 
            260                 265                 270         


Leu Lys Thr Trp Thr Ala Ala Asp Phe Ala Ala Gln Ile Thr Arg Asn 
        275                 280                 285             


Lys Trp Glu Arg Ala Arg Tyr Ala Glu Arg Leu Arg Ala Tyr Leu Glu 
    290                 295                 300                 


Gly Thr Cys Val Glu Trp Leu Ser Arg Tyr Leu Glu Leu Gly Lys Glu 
305                 310                 315                 320 


Thr Leu Leu Arg Ser Asp Pro Pro Glu Ala His Val Thr Leu His Pro 
                325                 330                 335     


Arg Pro Glu Gly Asp Val Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 
            340                 345                 350         


Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Asp Leu Thr 
        355                 360                 365             


Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe 
    370                 375                 380                 


Gln Lys Trp Ala Ser Val Val Val Pro Leu Gly Lys Glu Gln Asn Tyr 
385                 390                 395                 400 


Thr Cys Arg Val Glu His Glu Gly Leu Pro Lys Pro Leu Ser Gln Arg 
                405                 410                 415     


Trp Gly Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp 
            420                 425                 430         


His Glu His His His His His His 
        435                 440 


<210>  30
<211>  440
<212>  PRT
<213>  Artificial

<220>
<223>  exemplary human HLA-G/ rat RT1A 2M MHC class I complex wherein 
       the positions specific for human HLA-G are grafted onto the rat 
       RT1A framework

<400>  30

Ala Gln Phe Ser Ala Ser Ala Ser Arg Gly Cys Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Lys Thr Pro Gln Ile Gln 
            20                  25                  30          


Val Tyr Ser Arg His Pro Pro Glu Asn Gly Lys Pro Asn Phe Leu Asn 
        35                  40                  45              


Cys Tyr Val Ser Gln Phe His Pro Pro Gln Ile Glu Ile Glu Leu Leu 
    50                  55                  60                  


Lys Asn Gly Lys Lys Ile Pro Asn Ile Glu Met Ser Asp Leu Ser Phe 
65                  70                  75                  80  


Ser Lys Asp Trp Ser Phe Tyr Ile Leu Ala His Thr Glu Phe Thr Pro 
                85                  90                  95      


Thr Glu Thr Asp Val Tyr Ala Cys Arg Val Lys His Val Thr Leu Lys 
            100                 105                 110         


Glu Pro Lys Thr Val Thr Trp Asp Arg Asp Met Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Ser His Ser Leu Arg Tyr Phe Tyr Thr Ala Val Ser Arg Pro Gly Leu 
145                 150                 155                 160 


Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Glu Phe 
                165                 170                 175     


Val Arg Phe Asp Ser Asp Ser Ala Ser Pro Arg Met Glu Pro Arg Ala 
            180                 185                 190         


Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Glu Gln Gln Thr Arg 
        195                 200                 205             


Ile Ala Lys Glu Trp Glu Gln Ile Tyr Arg Met Asp Leu Gln Thr Leu 
    210                 215                 220                 


Arg Gly Cys Tyr Asn Gln Ser Glu Ala Ser Ser His Thr Ile Gln Glu 
225                 230                 235                 240 


Met Tyr Gly Cys Asp Leu Gly Ser Asp Gly Arg Leu Leu Arg Gly Tyr 
                245                 250                 255     


Arg Gln Asp Ala Tyr Asp Gly Arg Asp Tyr Ile Ala Leu Asn Glu Asp 
            260                 265                 270         


Leu Arg Ser Trp Thr Ala Ala Asp Phe Ala Ala Gln Ile Thr Lys Arg 
        275                 280                 285             


Lys Trp Glu Ala Ala Asn Tyr Ala Glu Arg Leu Arg Ala Tyr Leu Glu 
    290                 295                 300                 


Gly Thr Cys Val Glu Trp Leu His Arg Tyr Leu Glu Asn Gly Lys Glu 
305                 310                 315                 320 


Met Leu Gln Arg Ala Asp Pro Pro Glu Ala His Val Thr His His Pro 
                325                 330                 335     


Val Phe Asp Tyr Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 
            340                 345                 350         


Pro Ala Glu Ile Ile Leu Thr Trp Gln Leu Asn Gly Glu Asp Leu Thr 
        355                 360                 365             


Gln Asp Val Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe 
    370                 375                 380                 


Gln Lys Trp Ala Ser Val Val Val Pro Ser Gly Lys Glu Gln Asn Tyr 
385                 390                 395                 400 


Thr Cys Arg Val Gln His Glu Gly Leu Pro Lys Pro Leu Met Leu Arg 
                405                 410                 415     


Trp Gly Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp 
            420                 425                 430         


His Glu His His His His His His 
        435                 440 


<210>  31
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  linker and his-Tag

<400>  31

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Gly Leu Asn Asp 
1               5                   10                  15      


Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu His His His His His 
            20                  25                  30          


His 
    


<210>  32
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  32

Val Leu Asp Phe Ala Pro Pro Gly Ala 
1               5                   


<210>  33
<211>  107
<212>  PRT
<213>  Homo Sapiens

<400>  33

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  34
<211>  105
<212>  PRT
<213>  Homo Sapiens

<400>  34

Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
            20                  25                  30          


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
        35                  40                  45              


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
    50                  55                  60                  


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
65                  70                  75                  80  


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
                85                  90                  95      


Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105 


<210>  35
<211>  328
<212>  PRT
<213>  Homo Sapiens

<400>  35

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro 
                325             


<210>  36
<211>  328
<212>  PRT
<213>  homo sapiens

<400>  36

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro 
                325             


<210>  37
<211>  325
<212>  PRT
<213>  Homo Sapiens

<400>  37

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu 
                325 


<210>  38
<211>  122
<212>  PRT
<213>  rat

<400>  38

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Ser Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asn Asp Tyr 
            20                  25                  30          


Trp Met Thr Trp Thr Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr Asn Ser Gly Gly Arg Thr Tyr Tyr Leu Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Gln Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Lys Glu Arg Ile Tyr Leu Thr Ala Tyr Trp Phe Phe Asp Phe Trp 
            100                 105                 110         


Gly Pro Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  39
<211>  106
<212>  PRT
<213>  rat

<400>  39

Asp Thr Ile Leu Thr Gln Ser Pro Ala Leu Ala Val Ser Pro Gly Glu 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Ser Thr Leu Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Leu Ala Ser His Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Glu Ala Asp 
65                  70                  75                  80  


Asp Thr Ala Thr Tyr Tyr Cys Gln Gln Ser Trp Asn Glu Pro Arg Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


