                         SEQUENCE LISTING

<110>  Charit - Universittsmedizin Berlin
       Roche Sequencing Solutions, Inc.
       Ventana Medical Systems, Inc.
 
<120>  COMPOSITIONS AND METHODS FOR PROGNOSING AND TREATING COLORECTAL 
       CANCER

<130>  R71265PC

<150>  US 62/422,573
<151>  2016-11-15

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid primer

<400>  1
ttcttttgat tcctccggtg a                                                 21


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Primer

<400>  2
actctgatgg gcatgtgctg                                                   20


<210>  3
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid probe

<400>  3
gcagacttcc tcaagaaatt ctggaagatc ta                                     32


<210>  4
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid probe

<400>  4
agtgtttcag aacttctgga cattttagac ga                                     32


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid primer

<400>  5
attgacatgg aagctggaaa actc                                              24


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid primer

<400>  6
cacgaagggt gaaagcatcc                                                   20


<210>  7
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid probe

<400>  7
tacagaatgc caggacccag acttgcttca caattgg                                37


<210>  8
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid primer

<400>  8
tgctgtgtct ggtggcc                                                      17


<210>  9
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid primer

<400>  9
gcatttcaac accttgacct tct                                               23


<210>  10
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid probe

<400>  10
agaagcccgc ctccaccaac tcagatgac                                         29


<210>  11
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid primer

<400>  11
gaccttgatt tattttgcat accta                                             25


<210>  12
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid primer

<400>  12
gagcaagacg ttcagtcct                                                    19


<210>  13
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid probe

<400>  13
atgctgagga tttggaaagg gtgtttattc                                        30


<210>  14
<211>  852
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Leu Ile Thr Glu Arg Lys His Phe Arg Ser Gly Arg Ile Ala Gln 
1               5                   10                  15      


Ser Met Ser Glu Ala Asn Leu Ile Asp Met Glu Ala Gly Lys Leu Ser 
            20                  25                  30          


Lys Ser Cys Asn Ile Thr Glu Cys Gln Asp Pro Asp Leu Leu His Asn 
        35                  40                  45              


Trp Pro Asp Ala Phe Thr Leu Arg Gly Asn Asn Ala Ser Lys Val Ala 
    50                  55                  60                  


Asn Pro Phe Trp Asn Gln Leu Ser Ala Ser Asn Pro Phe Leu Asp Asp 
65                  70                  75                  80  


Ile Thr Gln Leu Arg Asn Asn Arg Lys Arg Asn Asn Ile Ser Ile Leu 
                85                  90                  95      


Lys Glu Asp Pro Phe Leu Phe Cys Arg Glu Ile Glu Asn Gly Asn Ser 
            100                 105                 110         


Phe Asp Ser Ser Gly Asp Glu Leu Asp Val His Gln Leu Leu Arg Gln 
        115                 120                 125             


Thr Ser Ser Arg Asn Ser Gly Arg Ser Lys Ser Val Ser Glu Leu Leu 
    130                 135                 140                 


Asp Ile Leu Asp Asp Thr Ala His Ala His Gln Ser Ile His Asn Ser 
145                 150                 155                 160 


Asp Gln Ile Leu Leu His Asp Leu Glu Trp Leu Lys Asn Asp Arg Glu 
                165                 170                 175     


Ala Tyr Lys Met Ala Trp Leu Ser Gln Arg Gln Leu Ala Arg Ser Cys 
            180                 185                 190         


Leu Asp Leu Asn Thr Ile Ser Gln Ser Pro Gly Trp Ala Gln Thr Gln 
        195                 200                 205             


Leu Ala Glu Val Thr Ile Ala Cys Lys Val Asn His Gln Gly Gly Ser 
    210                 215                 220                 


Val Gln Leu Pro Glu Ser Asp Ile Thr Val His Val Pro Gln Gly His 
225                 230                 235                 240 


Val Ala Val Gly Glu Phe Gln Glu Val Ser Leu Arg Ala Phe Leu Asp 
                245                 250                 255     


Pro Pro His Met Leu Asn His Asp Leu Ser Cys Thr Val Ser Pro Leu 
            260                 265                 270         


Leu Glu Ile Met Leu Gly Asn Leu Asn Thr Met Glu Ala Leu Leu Leu 
        275                 280                 285             


Glu Met Lys Ile Gly Ala Glu Val Arg Lys Asp Pro Phe Ser Gln Val 
    290                 295                 300                 


Met Thr Glu Met Val Cys Leu His Ser Leu Gly Lys Glu Gly Pro Phe 
305                 310                 315                 320 


Lys Val Leu Ser Asn Cys Tyr Ile Tyr Lys Asp Thr Ile Gln Val Lys 
                325                 330                 335     


Leu Ile Asp Leu Ser Gln Val Met Tyr Leu Val Val Ala Ala Gln Ala 
            340                 345                 350         


Lys Ala Leu Pro Ser Pro Ala Ala Thr Ile Trp Asp Tyr Ile His Lys 
        355                 360                 365             


Thr Thr Ser Ile Gly Ile Tyr Gly Pro Lys Tyr Ile His Pro Ser Phe 
    370                 375                 380                 


Thr Val Val Leu Thr Val Cys Gly His Asn Tyr Met Pro Gly Gln Leu 
385                 390                 395                 400 


Thr Ile Ser Asp Ile Lys Lys Gly Gly Lys Asn Ile Ser Pro Val Val 
                405                 410                 415     


Phe Gln Leu Trp Gly Lys Gln Ser Phe Leu Leu Asp Lys Pro Gln Asp 
            420                 425                 430         


Leu Ser Ile Ser Ile Phe Ser Cys Asp Pro Asp Phe Glu Val Lys Thr 
        435                 440                 445             


Glu Gly Glu Arg Lys Glu Ile Lys Gln Lys Gln Leu Glu Ala Gly Glu 
    450                 455                 460                 


Val Val His Gln Gln Phe Leu Phe Ser Leu Val Glu His Arg Glu Met 
465                 470                 475                 480 


His Leu Phe Asp Phe Cys Val Gln Val Glu Pro Pro Asn Gly Glu Pro 
                485                 490                 495     


Val Ala Gln Phe Ser Ile Thr Thr Pro Asp Pro Thr Pro Asn Leu Lys 
            500                 505                 510         


Arg Leu Ser Asn Leu Pro Gly Tyr Leu Gln Lys Lys Glu Glu Ile Lys 
        515                 520                 525             


Ser Ala Pro Leu Ser Pro Lys Ile Leu Val Lys Tyr Pro Thr Phe Gln 
    530                 535                 540                 


Asp Lys Thr Leu Asn Phe Ser Asn Tyr Gly Val Thr Leu Lys Ala Val 
545                 550                 555                 560 


Leu Arg Gln Ser Lys Ile Asp Tyr Phe Leu Glu Tyr Phe Lys Gly Asp 
                565                 570                 575     


Thr Ile Ala Leu Leu Gly Glu Gly Lys Val Lys Ala Ile Gly Gln Ser 
            580                 585                 590         


Lys Val Lys Glu Trp Tyr Val Gly Val Leu Arg Gly Lys Ile Gly Leu 
        595                 600                 605             


Val His Cys Lys Asn Val Lys Val Ile Ser Lys Glu Gln Val Met Phe 
    610                 615                 620                 


Met Ser Asp Ser Val Phe Thr Thr Arg Asn Leu Leu Glu Gln Ile Val 
625                 630                 635                 640 


Leu Pro Leu Lys Lys Leu Thr Tyr Ile Tyr Ser Val Val Leu Thr Leu 
                645                 650                 655     


Val Ser Glu Lys Val Tyr Asp Trp Lys Val Leu Ala Asp Val Leu Gly 
            660                 665                 670         


Tyr Ser His Leu Ser Leu Glu Asp Phe Asp Gln Ile Gln Ala Asp Lys 
        675                 680                 685             


Glu Ser Glu Lys Val Ser Tyr Val Ile Lys Lys Leu Lys Glu Asp Cys 
    690                 695                 700                 


His Thr Glu Arg Asn Thr Arg Lys Phe Leu Tyr Glu Leu Ile Val Ala 
705                 710                 715                 720 


Leu Leu Lys Met Asp Cys Gln Glu Leu Val Ala Arg Leu Ile Gln Glu 
                725                 730                 735     


Ala Ala Val Leu Thr Ser Ala Val Lys Leu Gly Lys Gly Trp Arg Glu 
            740                 745                 750         


Leu Ala Glu Lys Leu Val Arg Leu Thr Lys Gln Gln Met Glu Ala Tyr 
        755                 760                 765             


Glu Ile Pro His Arg Gly Asn Thr Gly Asp Val Ala Val Glu Met Met 
    770                 775                 780                 


Trp Lys Pro Ala Tyr Asp Phe Leu Tyr Thr Trp Ser Ala His Tyr Gly 
785                 790                 795                 800 


Asn Asn Tyr Arg Asp Val Leu Gln Asp Leu Gln Ser Ala Leu Asp Arg 
                805                 810                 815     


Met Lys Asn Pro Val Thr Lys His Trp Arg Glu Leu Thr Gly Val Leu 
            820                 825                 830         


Ile Leu Val Asn Ser Leu Glu Val Leu Arg Val Thr Ala Phe Ser Thr 
        835                 840                 845             


Ser Glu Glu Val 
    850         


<210>  15
<211>  756
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Phe Val Ala Gly Val Ile Arg Arg Leu Asp Glu Thr Val Val 
1               5                   10                  15      


Asn Arg Ile Ala Ala Gly Glu Val Ile Gln Arg Pro Ala Asn Ala Ile 
            20                  25                  30          


Lys Glu Met Ile Glu Asn Cys Leu Asp Ala Lys Ser Thr Ser Ile Gln 
        35                  40                  45              


Val Ile Val Lys Glu Gly Gly Leu Lys Leu Ile Gln Ile Gln Asp Asn 
    50                  55                  60                  


Gly Thr Gly Ile Arg Lys Glu Asp Leu Asp Ile Val Cys Glu Arg Phe 
65                  70                  75                  80  


Thr Thr Ser Lys Leu Gln Ser Phe Glu Asp Leu Ala Ser Ile Ser Thr 
                85                  90                  95      


Tyr Gly Phe Arg Gly Glu Ala Leu Ala Ser Ile Ser His Val Ala His 
            100                 105                 110         


Val Thr Ile Thr Thr Lys Thr Ala Asp Gly Lys Cys Ala Tyr Arg Ala 
        115                 120                 125             


Ser Tyr Ser Asp Gly Lys Leu Lys Ala Pro Pro Lys Pro Cys Ala Gly 
    130                 135                 140                 


Asn Gln Gly Thr Gln Ile Thr Val Glu Asp Leu Phe Tyr Asn Ile Ala 
145                 150                 155                 160 


Thr Arg Arg Lys Ala Leu Lys Asn Pro Ser Glu Glu Tyr Gly Lys Ile 
                165                 170                 175     


Leu Glu Val Val Gly Arg Tyr Ser Val His Asn Ala Gly Ile Ser Phe 
            180                 185                 190         


Ser Val Lys Lys Gln Gly Glu Thr Val Ala Asp Val Arg Thr Leu Pro 
        195                 200                 205             


Asn Ala Ser Thr Val Asp Asn Ile Arg Ser Ile Phe Gly Asn Ala Val 
    210                 215                 220                 


Ser Arg Glu Leu Ile Glu Ile Gly Cys Glu Asp Lys Thr Leu Ala Phe 
225                 230                 235                 240 


Lys Met Asn Gly Tyr Ile Ser Asn Ala Asn Tyr Ser Val Lys Lys Cys 
                245                 250                 255     


Ile Phe Leu Leu Phe Ile Asn His Arg Leu Val Glu Ser Thr Ser Leu 
            260                 265                 270         


Arg Lys Ala Ile Glu Thr Val Tyr Ala Ala Tyr Leu Pro Lys Asn Thr 
        275                 280                 285             


His Pro Phe Leu Tyr Leu Ser Leu Glu Ile Ser Pro Gln Asn Val Asp 
    290                 295                 300                 


Val Asn Val His Pro Thr Lys His Glu Val His Phe Leu His Glu Glu 
305                 310                 315                 320 


Ser Ile Leu Glu Arg Val Gln Gln His Ile Glu Ser Lys Leu Leu Gly 
                325                 330                 335     


Ser Asn Ser Ser Arg Met Tyr Phe Thr Gln Thr Leu Leu Pro Gly Leu 
            340                 345                 350         


Ala Gly Pro Ser Gly Glu Met Val Lys Ser Thr Thr Ser Leu Thr Ser 
        355                 360                 365             


Ser Ser Thr Ser Gly Ser Ser Asp Lys Val Tyr Ala His Gln Met Val 
    370                 375                 380                 


Arg Thr Asp Ser Arg Glu Gln Lys Leu Asp Ala Phe Leu Gln Pro Leu 
385                 390                 395                 400 


Ser Lys Pro Leu Ser Ser Gln Pro Gln Ala Ile Val Thr Glu Asp Lys 
                405                 410                 415     


Thr Asp Ile Ser Ser Gly Arg Ala Arg Gln Gln Asp Glu Glu Met Leu 
            420                 425                 430         


Glu Leu Pro Ala Pro Ala Glu Val Ala Ala Lys Asn Gln Ser Leu Glu 
        435                 440                 445             


Gly Asp Thr Thr Lys Gly Thr Ser Glu Met Ser Glu Lys Arg Gly Pro 
    450                 455                 460                 


Thr Ser Ser Asn Pro Arg Lys Arg His Arg Glu Asp Ser Asp Val Glu 
465                 470                 475                 480 


Met Val Glu Asp Asp Ser Arg Lys Glu Met Thr Ala Ala Cys Thr Pro 
                485                 490                 495     


Arg Arg Arg Ile Ile Asn Leu Thr Ser Val Leu Ser Leu Gln Glu Glu 
            500                 505                 510         


Ile Asn Glu Gln Gly His Glu Val Leu Arg Glu Met Leu His Asn His 
        515                 520                 525             


Ser Phe Val Gly Cys Val Asn Pro Gln Trp Ala Leu Ala Gln His Gln 
    530                 535                 540                 


Thr Lys Leu Tyr Leu Leu Asn Thr Thr Lys Leu Ser Glu Glu Leu Phe 
545                 550                 555                 560 


Tyr Gln Ile Leu Ile Tyr Asp Phe Ala Asn Phe Gly Val Leu Arg Leu 
                565                 570                 575     


Ser Glu Pro Ala Pro Leu Phe Asp Leu Ala Met Leu Ala Leu Asp Ser 
            580                 585                 590         


Pro Glu Ser Gly Trp Thr Glu Glu Asp Gly Pro Lys Glu Gly Leu Ala 
        595                 600                 605             


Glu Tyr Ile Val Glu Phe Leu Lys Lys Lys Ala Glu Met Leu Ala Asp 
    610                 615                 620                 


Tyr Phe Ser Leu Glu Ile Asp Glu Glu Gly Asn Leu Ile Gly Leu Pro 
625                 630                 635                 640 


Leu Leu Ile Asp Asn Tyr Val Pro Pro Leu Glu Gly Leu Pro Ile Phe 
                645                 650                 655     


Ile Leu Arg Leu Ala Thr Glu Val Asn Trp Asp Glu Glu Lys Glu Cys 
            660                 665                 670         


Phe Glu Ser Leu Ser Lys Glu Cys Ala Met Phe Tyr Ser Ile Arg Lys 
        675                 680                 685             


Gln Tyr Ile Ser Glu Glu Ser Thr Leu Ser Gly Gln Gln Ser Glu Val 
    690                 695                 700                 


Pro Gly Ser Ile Pro Asn Ser Trp Lys Trp Thr Val Glu His Ile Val 
705                 710                 715                 720 


Tyr Lys Ala Leu Arg Ser His Ile Leu Pro Pro Lys His Phe Thr Glu 
                725                 730                 735     


Asp Gly Asn Ile Leu Gln Leu Ala Asn Leu Pro Asp Leu Tyr Lys Val 
            740                 745                 750         


Phe Glu Arg Cys 
        755     


<210>  16
<211>  934
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Val Gln Pro Lys Glu Thr Leu Gln Leu Glu Ser Ala Ala Glu 
1               5                   10                  15      


Val Gly Phe Val Arg Phe Phe Gln Gly Met Pro Glu Lys Pro Thr Thr 
            20                  25                  30          


Thr Val Arg Leu Phe Asp Arg Gly Asp Phe Tyr Thr Ala His Gly Glu 
        35                  40                  45              


Asp Ala Leu Leu Ala Ala Arg Glu Val Phe Lys Thr Gln Gly Val Ile 
    50                  55                  60                  


Lys Tyr Met Gly Pro Ala Gly Ala Lys Asn Leu Gln Ser Val Val Leu 
65                  70                  75                  80  


Ser Lys Met Asn Phe Glu Ser Phe Val Lys Asp Leu Leu Leu Val Arg 
                85                  90                  95      


Gln Tyr Arg Val Glu Val Tyr Lys Asn Arg Ala Gly Asn Lys Ala Ser 
            100                 105                 110         


Lys Glu Asn Asp Trp Tyr Leu Ala Tyr Lys Ala Ser Pro Gly Asn Leu 
        115                 120                 125             


Ser Gln Phe Glu Asp Ile Leu Phe Gly Asn Asn Asp Met Ser Ala Ser 
    130                 135                 140                 


Ile Gly Val Val Gly Val Lys Met Ser Ala Val Asp Gly Gln Arg Gln 
145                 150                 155                 160 


Val Gly Val Gly Tyr Val Asp Ser Ile Gln Arg Lys Leu Gly Leu Cys 
                165                 170                 175     


Glu Phe Pro Asp Asn Asp Gln Phe Ser Asn Leu Glu Ala Leu Leu Ile 
            180                 185                 190         


Gln Ile Gly Pro Lys Glu Cys Val Leu Pro Gly Gly Glu Thr Ala Gly 
        195                 200                 205             


Asp Met Gly Lys Leu Arg Gln Ile Ile Gln Arg Gly Gly Ile Leu Ile 
    210                 215                 220                 


Thr Glu Arg Lys Lys Ala Asp Phe Ser Thr Lys Asp Ile Tyr Gln Asp 
225                 230                 235                 240 


Leu Asn Arg Leu Leu Lys Gly Lys Lys Gly Glu Gln Met Asn Ser Ala 
                245                 250                 255     


Val Leu Pro Glu Met Glu Asn Gln Val Ala Val Ser Ser Leu Ser Ala 
            260                 265                 270         


Val Ile Lys Phe Leu Glu Leu Leu Ser Asp Asp Ser Asn Phe Gly Gln 
        275                 280                 285             


Phe Glu Leu Thr Thr Phe Asp Phe Ser Gln Tyr Met Lys Leu Asp Ile 
    290                 295                 300                 


Ala Ala Val Arg Ala Leu Asn Leu Phe Gln Gly Ser Val Glu Asp Thr 
305                 310                 315                 320 


Thr Gly Ser Gln Ser Leu Ala Ala Leu Leu Asn Lys Cys Lys Thr Pro 
                325                 330                 335     


Gln Gly Gln Arg Leu Val Asn Gln Trp Ile Lys Gln Pro Leu Met Asp 
            340                 345                 350         


Lys Asn Arg Ile Glu Glu Arg Leu Asn Leu Val Glu Ala Phe Val Glu 
        355                 360                 365             


Asp Ala Glu Leu Arg Gln Thr Leu Gln Glu Asp Leu Leu Arg Arg Phe 
    370                 375                 380                 


Pro Asp Leu Asn Arg Leu Ala Lys Lys Phe Gln Arg Gln Ala Ala Asn 
385                 390                 395                 400 


Leu Gln Asp Cys Tyr Arg Leu Tyr Gln Gly Ile Asn Gln Leu Pro Asn 
                405                 410                 415     


Val Ile Gln Ala Leu Glu Lys His Glu Gly Lys His Gln Lys Leu Leu 
            420                 425                 430         


Leu Ala Val Phe Val Thr Pro Leu Thr Asp Leu Arg Ser Asp Phe Ser 
        435                 440                 445             


Lys Phe Gln Glu Met Ile Glu Thr Thr Leu Asp Met Asp Gln Val Glu 
    450                 455                 460                 


Asn His Glu Phe Leu Val Lys Pro Ser Phe Asp Pro Asn Leu Ser Glu 
465                 470                 475                 480 


Leu Arg Glu Ile Met Asn Asp Leu Glu Lys Lys Met Gln Ser Thr Leu 
                485                 490                 495     


Ile Ser Ala Ala Arg Asp Leu Gly Leu Asp Pro Gly Lys Gln Ile Lys 
            500                 505                 510         


Leu Asp Ser Ser Ala Gln Phe Gly Tyr Tyr Phe Arg Val Thr Cys Lys 
        515                 520                 525             


Glu Glu Lys Val Leu Arg Asn Asn Lys Asn Phe Ser Thr Val Asp Ile 
    530                 535                 540                 


Gln Lys Asn Gly Val Lys Phe Thr Asn Ser Lys Leu Thr Ser Leu Asn 
545                 550                 555                 560 


Glu Glu Tyr Thr Lys Asn Lys Thr Glu Tyr Glu Glu Ala Gln Asp Ala 
                565                 570                 575     


Ile Val Lys Glu Ile Val Asn Ile Ser Ser Gly Tyr Val Glu Pro Met 
            580                 585                 590         


Gln Thr Leu Asn Asp Val Leu Ala Gln Leu Asp Ala Val Val Ser Phe 
        595                 600                 605             


Ala His Val Ser Asn Gly Ala Pro Val Pro Tyr Val Arg Pro Ala Ile 
    610                 615                 620                 


Leu Glu Lys Gly Gln Gly Arg Ile Ile Leu Lys Ala Ser Arg His Ala 
625                 630                 635                 640 


Cys Val Glu Val Gln Asp Glu Ile Ala Phe Ile Pro Asn Asp Val Tyr 
                645                 650                 655     


Phe Glu Lys Asp Lys Gln Met Phe His Ile Ile Thr Gly Pro Asn Met 
            660                 665                 670         


Gly Gly Lys Ser Thr Tyr Ile Arg Gln Thr Gly Val Ile Val Leu Met 
        675                 680                 685             


Ala Gln Ile Gly Cys Phe Val Pro Cys Glu Ser Ala Glu Val Ser Ile 
    690                 695                 700                 


Val Asp Cys Ile Leu Ala Arg Val Gly Ala Gly Asp Ser Gln Leu Lys 
705                 710                 715                 720 


Gly Val Ser Thr Phe Met Ala Glu Met Leu Glu Thr Ala Ser Ile Leu 
                725                 730                 735     


Arg Ser Ala Thr Lys Asp Ser Leu Ile Ile Ile Asp Glu Leu Gly Arg 
            740                 745                 750         


Gly Thr Ser Thr Tyr Asp Gly Phe Gly Leu Ala Trp Ala Ile Ser Glu 
        755                 760                 765             


Tyr Ile Ala Thr Lys Ile Gly Ala Phe Cys Met Phe Ala Thr His Phe 
    770                 775                 780                 


His Glu Leu Thr Ala Leu Ala Asn Gln Ile Pro Thr Val Asn Asn Leu 
785                 790                 795                 800 


His Val Thr Ala Leu Thr Thr Glu Glu Thr Leu Thr Met Leu Tyr Gln 
                805                 810                 815     


Val Lys Lys Gly Val Cys Asp Gln Ser Phe Gly Ile His Val Ala Glu 
            820                 825                 830         


Leu Ala Asn Phe Pro Lys His Val Ile Glu Cys Ala Lys Gln Lys Ala 
        835                 840                 845             


Leu Glu Leu Glu Glu Phe Gln Tyr Ile Gly Glu Ser Gln Gly Tyr Asp 
    850                 855                 860                 


Ile Met Glu Pro Ala Ala Lys Lys Cys Tyr Leu Glu Arg Glu Gln Gly 
865                 870                 875                 880 


Glu Lys Ile Ile Gln Glu Phe Leu Ser Lys Val Lys Gln Met Pro Phe 
                885                 890                 895     


Thr Glu Met Ser Glu Glu Asn Ile Thr Ile Lys Leu Lys Gln Leu Lys 
            900                 905                 910         


Ala Glu Val Ile Ala Lys Asn Asn Ser Phe Val Asn Glu Ile Ile Ser 
        915                 920                 925             


Arg Ile Lys Val Thr Thr 
    930                 


<210>  17
<211>  1360
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ser Arg Gln Ser Thr Leu Tyr Ser Phe Phe Pro Lys Ser Pro Ala 
1               5                   10                  15      


Leu Ser Asp Ala Asn Lys Ala Ser Ala Arg Ala Ser Arg Glu Gly Gly 
            20                  25                  30          


Arg Ala Ala Ala Ala Pro Gly Ala Ser Pro Ser Pro Gly Gly Asp Ala 
        35                  40                  45              


Ala Trp Ser Glu Ala Gly Pro Gly Pro Arg Pro Leu Ala Arg Ser Ala 
    50                  55                  60                  


Ser Pro Pro Lys Ala Lys Asn Leu Asn Gly Gly Leu Arg Arg Ser Val 
65                  70                  75                  80  


Ala Pro Ala Ala Pro Thr Ser Cys Asp Phe Ser Pro Gly Asp Leu Val 
                85                  90                  95      


Trp Ala Lys Met Glu Gly Tyr Pro Trp Trp Pro Cys Leu Val Tyr Asn 
            100                 105                 110         


His Pro Phe Asp Gly Thr Phe Ile Arg Glu Lys Gly Lys Ser Val Arg 
        115                 120                 125             


Val His Val Gln Phe Phe Asp Asp Ser Pro Thr Arg Gly Trp Val Ser 
    130                 135                 140                 


Lys Arg Leu Leu Lys Pro Tyr Thr Gly Ser Lys Ser Lys Glu Ala Gln 
145                 150                 155                 160 


Lys Gly Gly His Phe Tyr Ser Ala Lys Pro Glu Ile Leu Arg Ala Met 
                165                 170                 175     


Gln Arg Ala Asp Glu Ala Leu Asn Lys Asp Lys Ile Lys Arg Leu Glu 
            180                 185                 190         


Leu Ala Val Cys Asp Glu Pro Ser Glu Pro Glu Glu Glu Glu Glu Met 
        195                 200                 205             


Glu Val Gly Thr Thr Tyr Val Thr Asp Lys Ser Glu Glu Asp Asn Glu 
    210                 215                 220                 


Ile Glu Ser Glu Glu Glu Val Gln Pro Lys Thr Gln Gly Ser Arg Arg 
225                 230                 235                 240 


Ser Ser Arg Gln Ile Lys Lys Arg Arg Val Ile Ser Asp Ser Glu Ser 
                245                 250                 255     


Asp Ile Gly Gly Ser Asp Val Glu Phe Lys Pro Asp Thr Lys Glu Glu 
            260                 265                 270         


Gly Ser Ser Asp Glu Ile Ser Ser Gly Val Gly Asp Ser Glu Ser Glu 
        275                 280                 285             


Gly Leu Asn Ser Pro Val Lys Val Ala Arg Lys Arg Lys Arg Met Val 
    290                 295                 300                 


Thr Gly Asn Gly Ser Leu Lys Arg Lys Ser Ser Arg Lys Glu Thr Pro 
305                 310                 315                 320 


Ser Ala Thr Lys Gln Ala Thr Ser Ile Ser Ser Glu Thr Lys Asn Thr 
                325                 330                 335     


Leu Arg Ala Phe Ser Ala Pro Gln Asn Ser Glu Ser Gln Ala His Val 
            340                 345                 350         


Ser Gly Gly Gly Asp Asp Ser Ser Arg Pro Thr Val Trp Tyr His Glu 
        355                 360                 365             


Thr Leu Glu Trp Leu Lys Glu Glu Lys Arg Arg Asp Glu His Arg Arg 
    370                 375                 380                 


Arg Pro Asp His Pro Asp Phe Asp Ala Ser Thr Leu Tyr Val Pro Glu 
385                 390                 395                 400 


Asp Phe Leu Asn Ser Cys Thr Pro Gly Met Arg Lys Trp Trp Gln Ile 
                405                 410                 415     


Lys Ser Gln Asn Phe Asp Leu Val Ile Cys Tyr Lys Val Gly Lys Phe 
            420                 425                 430         


Tyr Glu Leu Tyr His Met Asp Ala Leu Ile Gly Val Ser Glu Leu Gly 
        435                 440                 445             


Leu Val Phe Met Lys Gly Asn Trp Ala His Ser Gly Phe Pro Glu Ile 
    450                 455                 460                 


Ala Phe Gly Arg Tyr Ser Asp Ser Leu Val Gln Lys Gly Tyr Lys Val 
465                 470                 475                 480 


Ala Arg Val Glu Gln Thr Glu Thr Pro Glu Met Met Glu Ala Arg Cys 
                485                 490                 495     


Arg Lys Met Ala His Ile Ser Lys Tyr Asp Arg Val Val Arg Arg Glu 
            500                 505                 510         


Ile Cys Arg Ile Ile Thr Lys Gly Thr Gln Thr Tyr Ser Val Leu Glu 
        515                 520                 525             


Gly Asp Pro Ser Glu Asn Tyr Ser Lys Tyr Leu Leu Ser Leu Lys Glu 
    530                 535                 540                 


Lys Glu Glu Asp Ser Ser Gly His Thr Arg Ala Tyr Gly Val Cys Phe 
545                 550                 555                 560 


Val Asp Thr Ser Leu Gly Lys Phe Phe Ile Gly Gln Phe Ser Asp Asp 
                565                 570                 575     


Arg His Cys Ser Arg Phe Arg Thr Leu Val Ala His Tyr Pro Pro Val 
            580                 585                 590         


Gln Val Leu Phe Glu Lys Gly Asn Leu Ser Lys Glu Thr Lys Thr Ile 
        595                 600                 605             


Leu Lys Ser Ser Leu Ser Cys Ser Leu Gln Glu Gly Leu Ile Pro Gly 
    610                 615                 620                 


Ser Gln Phe Trp Asp Ala Ser Lys Thr Leu Arg Thr Leu Leu Glu Glu 
625                 630                 635                 640 


Glu Tyr Phe Arg Glu Lys Leu Ser Asp Gly Ile Gly Val Met Leu Pro 
                645                 650                 655     


Gln Val Leu Lys Gly Met Thr Ser Glu Ser Asp Ser Ile Gly Leu Thr 
            660                 665                 670         


Pro Gly Glu Lys Ser Glu Leu Ala Leu Ser Ala Leu Gly Gly Cys Val 
        675                 680                 685             


Phe Tyr Leu Lys Lys Cys Leu Ile Asp Gln Glu Leu Leu Ser Met Ala 
    690                 695                 700                 


Asn Phe Glu Glu Tyr Ile Pro Leu Asp Ser Asp Thr Val Ser Thr Thr 
705                 710                 715                 720 


Arg Ser Gly Ala Ile Phe Thr Lys Ala Tyr Gln Arg Met Val Leu Asp 
                725                 730                 735     


Ala Val Thr Leu Asn Asn Leu Glu Ile Phe Leu Asn Gly Thr Asn Gly 
            740                 745                 750         


Ser Thr Glu Gly Thr Leu Leu Glu Arg Val Asp Thr Cys His Thr Pro 
        755                 760                 765             


Phe Gly Lys Arg Leu Leu Lys Gln Trp Leu Cys Ala Pro Leu Cys Asn 
    770                 775                 780                 


His Tyr Ala Ile Asn Asp Arg Leu Asp Ala Ile Glu Asp Leu Met Val 
785                 790                 795                 800 


Val Pro Asp Lys Ile Ser Glu Val Val Glu Leu Leu Lys Lys Leu Pro 
                805                 810                 815     


Asp Leu Glu Arg Leu Leu Ser Lys Ile His Asn Val Gly Ser Pro Leu 
            820                 825                 830         


Lys Ser Gln Asn His Pro Asp Ser Arg Ala Ile Met Tyr Glu Glu Thr 
        835                 840                 845             


Thr Tyr Ser Lys Lys Lys Ile Ile Asp Phe Leu Ser Ala Leu Glu Gly 
    850                 855                 860                 


Phe Lys Val Met Cys Lys Ile Ile Gly Ile Met Glu Glu Val Ala Asp 
865                 870                 875                 880 


Gly Phe Lys Ser Lys Ile Leu Lys Gln Val Ile Ser Leu Gln Thr Lys 
                885                 890                 895     


Asn Pro Glu Gly Arg Phe Pro Asp Leu Thr Val Glu Leu Asn Arg Trp 
            900                 905                 910         


Asp Thr Ala Phe Asp His Glu Lys Ala Arg Lys Thr Gly Leu Ile Thr 
        915                 920                 925             


Pro Lys Ala Gly Phe Asp Ser Asp Tyr Asp Gln Ala Leu Ala Asp Ile 
    930                 935                 940                 


Arg Glu Asn Glu Gln Ser Leu Leu Glu Tyr Leu Glu Lys Gln Arg Asn 
945                 950                 955                 960 


Arg Ile Gly Cys Arg Thr Ile Val Tyr Trp Gly Ile Gly Arg Asn Arg 
                965                 970                 975     


Tyr Gln Leu Glu Ile Pro Glu Asn Phe Thr Thr Arg Asn Leu Pro Glu 
            980                 985                 990         


Glu Tyr Glu Leu Lys Ser Thr Lys  Lys Gly Cys Lys Arg  Tyr Trp Thr 
        995                 1000                 1005             


Lys Thr  Ile Glu Lys Lys Leu  Ala Asn Leu Ile Asn  Ala Glu Glu 
    1010                 1015                 1020             


Arg Arg  Asp Val Ser Leu Lys  Asp Cys Met Arg Arg  Leu Phe Tyr 
    1025                 1030                 1035             


Asn Phe  Asp Lys Asn Tyr Lys  Asp Trp Gln Ser Ala  Val Glu Cys 
    1040                 1045                 1050             


Ile Ala  Val Leu Asp Val Leu  Leu Cys Leu Ala Asn  Tyr Ser Arg 
    1055                 1060                 1065             


Gly Gly  Asp Gly Pro Met Cys  Arg Pro Val Ile Leu  Leu Pro Glu 
    1070                 1075                 1080             


Asp Thr  Pro Pro Phe Leu Glu  Leu Lys Gly Ser Arg  His Pro Cys 
    1085                 1090                 1095             


Ile Thr  Lys Thr Phe Phe Gly  Asp Asp Phe Ile Pro  Asn Asp Ile 
    1100                 1105                 1110             


Leu Ile  Gly Cys Glu Glu Glu  Glu Gln Glu Asn Gly  Lys Ala Tyr 
    1115                 1120                 1125             


Cys Val  Leu Val Thr Gly Pro  Asn Met Gly Gly Lys  Ser Thr Leu 
    1130                 1135                 1140             


Met Arg  Gln Ala Gly Leu Leu  Ala Val Met Ala Gln  Met Gly Cys 
    1145                 1150                 1155             


Tyr Val  Pro Ala Glu Val Cys  Arg Leu Thr Pro Ile  Asp Arg Val 
    1160                 1165                 1170             


Phe Thr  Arg Leu Gly Ala Ser  Asp Arg Ile Met Ser  Gly Glu Ser 
    1175                 1180                 1185             


Thr Phe  Phe Val Glu Leu Ser  Glu Thr Ala Ser Ile  Leu Met His 
    1190                 1195                 1200             


Ala Thr  Ala His Ser Leu Val  Leu Val Asp Glu Leu  Gly Arg Gly 
    1205                 1210                 1215             


Thr Ala  Thr Phe Asp Gly Thr  Ala Ile Ala Asn Ala  Val Val Lys 
    1220                 1225                 1230             


Glu Leu  Ala Glu Thr Ile Lys  Cys Arg Thr Leu Phe  Ser Thr His 
    1235                 1240                 1245             


Tyr His  Ser Leu Val Glu Asp  Tyr Ser Gln Asn Val  Ala Val Arg 
    1250                 1255                 1260             


Leu Gly  His Met Ala Cys Met  Val Glu Asn Glu Cys  Glu Asp Pro 
    1265                 1270                 1275             


Ser Gln  Glu Thr Ile Thr Phe  Leu Tyr Lys Phe Ile  Lys Gly Ala 
    1280                 1285                 1290             


Cys Pro  Lys Ser Tyr Gly Phe  Asn Ala Ala Arg Leu  Ala Asn Leu 
    1295                 1300                 1305             


Pro Glu  Glu Val Ile Gln Lys  Gly His Arg Lys Ala  Arg Glu Phe 
    1310                 1315                 1320             


Glu Lys  Met Asn Gln Ser Leu  Arg Leu Phe Arg Glu  Val Cys Leu 
    1325                 1330                 1335             


Ala Ser  Glu Arg Ser Thr Val  Asp Ala Glu Ala Val  His Lys Leu 
    1340                 1345                 1350             


Leu Thr  Leu Ile Lys Glu Leu  
    1355                 1360 


<210>  18
<211>  2559
<212>  DNA
<213>  Homo sapiens

<400>  18
atgctaatca ctgaaagaaa acattttcgg tcaggaagaa ttgcacaaag tatgtctgaa       60

gcaaatttga ttgacatgga agctggaaaa ctctcaaaaa gttgcaatat tacagaatgc      120

caggacccag acttgcttca caattggccg gatgctttca cccttcgtgg taataatgct      180

tccaaagttg caaatccatt ctggaatcaa ctgtctgctt ctaacccatt tttggatgac      240

ataactcaac taagaaataa caggaagaga aataatattt ccatcttaaa ggaagatcct      300

tttcttttct gtagagaaat agaaaatgga aattcttttg attcctccgg tgatgaactt      360

gatgtgcatc agttacttag gcagacttcc tcaagaaatt ctggaagatc taaaagtgtt      420

tcagaacttc tggacatttt agacgacaca gcacatgccc atcagagtat acataactct      480

gaccagatcc tactacacga cttagagtgg cttaaaaatg atcgggaggc ttataaaatg      540

gcttggttaa gtcaacgcca gctggcccgc tcctgccttg atttgaatac aattagtcag      600

agccctggat gggcccagac acaacttgcg gaggtcacca tagcttgcaa agtaaaccat      660

caaggagggt cagtacaatt acctgaatca gacatcactg ttcatgtgcc ccaaggtcat      720

gtggctgtgg gagaattcca agaggtgtct ctaagggctt tccttgatcc gccacacatg      780

cttaaccatg atctttcgtg cactgtgagc ccgttgttgg aaatcatgtt aggcaacctc      840

aatacaatgg aagccctttt gctggagatg aaaattgggg ctgaagtaag aaaggatcct      900

ttcagccaag tcatgacaga aatggtgtgt ttacacagct tgggtaaaga aggccctttt      960

aaagttttaa gcaactgcta catttataaa gacaccatcc aagtcaagct aatcgacttg     1020

agtcaggtaa tgtatctagt ggttgctgca caagctaaag ctcttccgtc accagctgcc     1080

accatttggg attatatcca caaaaccacc tcaattggaa tttatggacc caaatatatc     1140

catcccagtt ttactgttgt tttaacagtt tgtggacaca attatatgcc aggacagctt     1200

acaatttctg atattaagaa gggtggaaaa aacatatctc cagttgtgtt tcagctctgg     1260

gggaagcagt catttttact tgacaagcca caagatttaa gtatttctat tttttcctgt     1320

gatcctgatt ttgaagtaaa gacagaagga gaaaggaaag aaattaaaca aaagcagttg     1380

gaagcaggtg aagtagttca tcaacaattt ttattttctt tagttgagca cagagagatg     1440

cacttgtttg atttttgtgt tcaagtggag cctcccaatg gtgaaccagt tgcacagttc     1500

tctatcacta ctcctgatcc aaccccaaac ctaaaaagac tctcgaatct gccaggctat     1560

ttgcagaaga aggaggaaat caagtctgct cctttatcac caaaaattct tgttaaatat     1620

cctacatttc aagataaaac attgaacttt agcaactatg gggtaaccct gaaggcagtg     1680

ctaagacaaa gcaagattga ttacttcctt gaatatttca aaggggacac aatagctctc     1740

ctcggggaag gtaaggtaaa agctattggt cagtccaaag tgaaagaatg gtatgtagga     1800

gtcctcagag gtaagattgg acttgtacac tgcaaaaatg tcaaggtgat ttcaaaggag     1860

caagtaatgt ttatgtcaga tagtgtcttt acaaccagaa atcttcttga acagattgtc     1920

ctgcctttaa aaaaattgac ttatatctac tcagttgtat taaccttggt gtcagaaaaa     1980

gtttatgatt ggaaagtttt agctgatgtc ctgggttact cacatctgtc cctggaagat     2040

tttgatcaaa ttcaagcaga caaagaatca gagaaagttt cttatgttat aaagaagtta     2100

aaggaagatt gccacacaga gagaaataca aggaagtttc tgtatgaact tattgtggct     2160

cttctgaaaa tggattgcca agagttagtc gcacgtctca tccaagaagc tgctgttctg     2220

acttcagctg tcaagcttgg aaaaggctgg agggaactag ctgaaaagtt agtacgactc     2280

acaaagcaac aaatggaggc atatgaaatt cctcatcgag gaaacactgg agatgttgct     2340

gttgagatga tgtggaaacc tgcctatgat tttctgtata cctggagtgc tcactatgga     2400

aataactaca gagatgtgtt acaagacctt cagtcagctt tggacagaat gaaaaaccct     2460

gtgactaaac actggagaga attaactgga gttttaatac tagtaaattc tttggaggtt     2520

ttgagagtaa ctgcattctc cacttctgag gaagtatag                            2559


<210>  19
<211>  1638
<212>  DNA
<213>  Homo sapiens

<400>  19
atgggccggc ggggctcagc ccccggaaac ggtcgtacac ttcggggctg cgagcgcgga       60

gggcgacgac gacgaagcgc agacagcgtc atggcagagc aggtggccct gagccggacc      120

caggtgtgcg ggatcctgcg ggaagagctt ttccagggcg atgccttcca tcagtcggat      180

acacacatat tcatcatcat gggtgcatcg ggtgacctgg ccaagaagaa gatctacccc      240

accatctggt ggctgttccg ggatggcctt ctgcccgaaa acaccttcat cgtgggctat      300

gcccgttccc gcctcacagt ggctgacatc cgcaaacaga gtgagccctt cttcaaggcc      360

accccagagg agaagctcaa gctggaggac ttctttgccc gcaactccta tgtggctggc      420

cagtacgatg atgcagcctc ctaccagcgc ctcaacagcc acatgaatgc cctccacctg      480

gggtcacagg ccaaccgcct cttctacctg gccttgcccc cgaccgtcta cgaggccgtc      540

accaagaaca ttcacgagtc ctgcatgagc cagataggct ggaaccgcat catcgtggag      600

aagcccttcg ggagggacct gcagagctct gaccggctgt ccaaccacat ctcctccctg      660

ttccgtgagg accagatcta ccgcatcgac cactacctgg gcaaggagat ggtgcagaac      720

ctcatggtgc tgagatttgc caacaggatc ttcggcccca tctggaaccg ggacaacatc      780

gcctgcgtta tcctcacctt caaggagccc tttggcactg agggtcgcgg gggctatttc      840

gatgaatttg ggatcatccg ggacgtgatg cagaaccacc tactgcagat gctgtgtctg      900

gtggccatgg agaagcccgc ctccaccaac tcagatgacg tccgtgatga gaaggtcaag      960

gtgttgaaat gcatctcaga ggtgcaggcc aacaatgtgg tcctgggcca gtacgtgggg     1020

aaccccgatg gagagggcga ggccaccaaa gggtacctgg acgaccccac ggtgccccgc     1080

gggtccacca ccgccacttt tgcagccgtc gtcctctatg tggagaatga gaggtgggat     1140

ggggtgccct tcatcctgcg ctgcggcaag gccctgaacg agcgcaaggc cgaggtgagg     1200

ctgcagttcc atgatgtggc cggcgacatc ttccaccagc agtgcaagcg caacgagctg     1260

gtgatccgcg tgcagcccaa cgaggccgtg tacaccaaga tgatgaccaa gaagccgggc     1320

atgttcttca accccgagga gtcggagctg gacctgacct acggcaacag atacaagaac     1380

gtgaagctcc ctgacgccta tgagcgcctc atcctggacg tcttctgcgg gagccagatg     1440

cacttcgtgc gcagcgacga gctccgtgag gcctggcgta ttttcacccc actgctgcac     1500

cagattgagc tggagaagcc caagcccatc ccctatattt atggcagccg aggccccacg     1560

gaggcagacg agctgatgaa gagagtgggt ttccagtatg agggcaccta caagtgggtg     1620

aacccccaca agctctga                                                   1638


<210>  20
<211>  1548
<212>  DNA
<213>  Homo sapiens

<400>  20
atggcagagc aggtggccct gagccggacc caggtgtgcg ggatcctgcg ggaagagctt       60

ttccagggcg atgccttcca tcagtcggat acacacatat tcatcatcat gggtgcatcg      120

ggtgacctgg ccaagaagaa gatctacccc accatctggt ggctgttccg ggatggcctt      180

ctgcccgaaa acaccttcat cgtgggctat gcccgttccc gcctcacagt ggctgacatc      240

cgcaaacaga gtgagccctt cttcaaggcc accccagagg agaagctcaa gctggaggac      300

ttctttgccc gcaactccta tgtggctggc cagtacgatg atgcagcctc ctaccagcgc      360

ctcaacagcc acatgaatgc cctccacctg gggtcacagg ccaaccgcct cttctacctg      420

gccttgcccc cgaccgtcta cgaggccgtc accaagaaca ttcacgagtc ctgcatgagc      480

cagataggct ggaaccgcat catcgtggag aagcccttcg ggagggacct gcagagctct      540

gaccggctgt ccaaccacat ctcctccctg ttccgtgagg accagatcta ccgcatcgac      600

cactacctgg gcaaggagat ggtgcagaac ctcatggtgc tgagatttgc caacaggatc      660

ttcggcccca tctggaaccg ggacaacatc gcctgcgtta tcctcacctt caaggagccc      720

tttggcactg agggtcgcgg gggctatttc gatgaatttg ggatcatccg ggacgtgatg      780

cagaaccacc tactgcagat gctgtgtctg gtggccatgg agaagcccgc ctccaccaac      840

tcagatgacg tccgtgatga gaaggtcaag gtgttgaaat gcatctcaga ggtgcaggcc      900

aacaatgtgg tcctgggcca gtacgtgggg aaccccgatg gagagggcga ggccaccaaa      960

gggtacctgg acgaccccac ggtgccccgc gggtccacca ccgccacttt tgcagccgtc     1020

gtcctctatg tggagaatga gaggtgggat ggggtgccct tcatcctgcg ctgcggcaag     1080

gccctgaacg agcgcaaggc cgaggtgagg ctgcagttcc atgatgtggc cggcgacatc     1140

ttccaccagc agtgcaagcg caacgagctg gtgatccgcg tgcagcccaa cgaggccgtg     1200

tacaccaaga tgatgaccaa gaagccgggc atgttcttca accccgagga gtcggagctg     1260

gacctgacct acggcaacag atacaagaac gtgaagctcc ctgacgccta tgagcgcctc     1320

atcctggacg tcttctgcgg gagccagatg cacttcgtgc gcagcgacga gctccgtgag     1380

gcctggcgta ttttcacccc actgctgcac cagattgagc tggagaagcc caagcccatc     1440

ccctatattt atggcagccg aggccccacg gaggcagacg agctgatgaa gagagtgggt     1500

ttccagtatg agggcaccta caagtgggtg aacccccaca agctctga                  1548


<210>  21
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Glu Gln Val Ala Leu Ser Arg Thr Gln Val Cys Gly Ile Leu 
1               5                   10                  15      


Arg Glu Glu Leu Phe Gln Gly Asp Ala Phe His Gln Ser Asp Thr His 
            20                  25                  30          


Ile Phe Ile Ile Met Gly Ala Ser Gly Asp Leu Ala Lys Lys Lys Ile 
        35                  40                  45              


Tyr Pro Thr Ile Trp Trp Leu Phe Arg Asp Gly Leu Leu Pro Glu Asn 
    50                  55                  60                  


Thr Phe Ile Val Gly Tyr Ala Arg Ser Arg Leu Thr Val Ala Asp Ile 
65                  70                  75                  80  


Arg Lys Gln Ser Glu Pro Phe Phe Lys Ala Thr Pro Glu Glu Lys Leu 
                85                  90                  95      


Lys Leu Glu Asp Phe Phe Ala Arg Asn Ser Tyr Val Ala Gly Gln Tyr 
            100                 105                 110         


Asp Asp Ala Ala Ser Tyr Gln Arg Leu Asn Ser His Met Asn Ala Leu 
        115                 120                 125             


His Leu Gly Ser Gln Ala Asn Arg Leu Phe Tyr Leu Ala Leu Pro Pro 
    130                 135                 140                 


Thr Val Tyr Glu Ala Val Thr Lys Asn Ile His Glu Ser Cys Met Ser 
145                 150                 155                 160 


Gln Ile Gly Trp Asn Arg Ile Ile Val Glu Lys Pro Phe Gly Arg Asp 
                165                 170                 175     


Leu Gln Ser Ser Asp Arg Leu Ser Asn His Ile Ser Ser Leu Phe Arg 
            180                 185                 190         


Glu Asp Gln Ile Tyr Arg Ile Asp His Tyr Leu Gly Lys Glu Met Val 
        195                 200                 205             


Gln Asn Leu Met Val Leu Arg Phe Ala Asn Arg Ile Phe Gly Pro Ile 
    210                 215                 220                 


Trp Asn Arg Asp Asn Ile Ala Cys Val Ile Leu Thr Phe Lys Glu Pro 
225                 230                 235                 240 


Phe Gly Thr Glu Gly Arg Gly Gly Tyr Phe Asp Glu Phe Gly Ile Ile 
                245                 250                 255     


Arg Asp Val Met Gln Asn His Leu Leu Gln Met Leu Cys Leu Val Ala 
            260                 265                 270         


Met Glu Lys Pro Ala Ser Thr Asn Ser Asp Asp Val Arg Asp Glu Lys 
        275                 280                 285             


Val Lys Val Leu Lys Cys Ile Ser Glu Val Gln Ala Asn Asn Val Val 
    290                 295                 300                 


Leu Gly Gln Tyr Val Gly Asn Pro Asp Gly Glu Gly Glu Ala Thr Lys 
305                 310                 315                 320 


Gly Tyr Leu Asp Asp Pro Thr Val Pro Arg Gly Ser Thr Thr Ala Thr 
                325                 330                 335     


Phe Ala Ala Val Val Leu Tyr Val Glu Asn Glu Arg Trp Asp Gly Val 
            340                 345                 350         


Pro Phe Ile Leu Arg Cys Gly Lys Ala Leu Asn Glu Arg Lys Ala Glu 
        355                 360                 365             


Val Arg Leu Gln Phe His Asp Val Ala Gly Asp Ile Phe His Gln Gln 
    370                 375                 380                 


Cys Lys Arg Asn Glu Leu Val Ile Arg Val Gln Pro Asn Glu Ala Val 
385                 390                 395                 400 


Tyr Thr Lys Met Met Thr Lys Lys Pro Gly Met Phe Phe Asn Pro Glu 
                405                 410                 415     


Glu Ser Glu Leu Asp Leu Thr Tyr Gly Asn Arg Tyr Lys Asn Val Lys 
            420                 425                 430         


Leu Pro Asp Ala Tyr Glu Arg Leu Ile Leu Asp Val Phe Cys Gly Ser 
        435                 440                 445             


Gln Met His Phe Val Arg Ser Asp Glu Leu Arg Glu Ala Trp Arg Ile 
    450                 455                 460                 


Phe Thr Pro Leu Leu His Gln Ile Glu Leu Glu Lys Pro Lys Pro Ile 
465                 470                 475                 480 


Pro Tyr Ile Tyr Gly Ser Arg Gly Pro Thr Glu Ala Asp Glu Leu Met 
                485                 490                 495     


Lys Arg Val Gly Phe Gln Tyr Glu Gly Thr Tyr Lys Trp Val Asn Pro 
            500                 505                 510         


His Lys Leu 
        515 


<210>  22
<211>  657
<212>  DNA
<213>  Homo sapiens

<400>  22
atggcgaccc gcagccctgg cgtcgtgatt agtgatgatg aaccaggtta tgaccttgat       60

ttattttgca tacctaatca ttatgctgag gatttggaaa gggtgtttat tcctcatgga      120

ctaattatgg acaggactga acgtcttgct cgagatgtga tgaaggagat gggaggccat      180

cacattgtag ccctctgtgt gctcaagggg ggctataaat tctttgctga cctgctggat      240

tacatcaaag cactgaatag aaatagtgat agatccattc ctatgactgt agattttatc      300

agactgaaga gctattgtaa tgaccagtca acaggggaca taaaagtaat tggtggagat      360

gatctctcaa ctttaactgg aaagaatgtc ttgattgtgg aagatataat tgacactggc      420

aaaacaatgc agactttgct ttccttggtc aggcagtata atccaaagat ggtcaaggtc      480

gcaagcttgc tggtgaaaag gaccccacga agtgttggat ataagccaga ctttgttgga      540

tttgaaattc cagacaagtt tgttgtagga tatgcccttg actataatga atacttcagg      600

gatttgaatc atgtttgtgt cattagtgaa actggaaaag caaaatacaa agcctaa         657


<210>  23
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Thr Arg Ser Pro Gly Val Val Ile Ser Asp Asp Glu Pro Gly 
1               5                   10                  15      


Tyr Asp Leu Asp Leu Phe Cys Ile Pro Asn His Tyr Ala Glu Asp Leu 
            20                  25                  30          


Glu Arg Val Phe Ile Pro His Gly Leu Ile Met Asp Arg Thr Glu Arg 
        35                  40                  45              


Leu Ala Arg Asp Val Met Lys Glu Met Gly Gly His His Ile Val Ala 
    50                  55                  60                  


Leu Cys Val Leu Lys Gly Gly Tyr Lys Phe Phe Ala Asp Leu Leu Asp 
65                  70                  75                  80  


Tyr Ile Lys Ala Leu Asn Arg Asn Ser Asp Arg Ser Ile Pro Met Thr 
                85                  90                  95      


Val Asp Phe Ile Arg Leu Lys Ser Tyr Cys Asn Asp Gln Ser Thr Gly 
            100                 105                 110         


Asp Ile Lys Val Ile Gly Gly Asp Asp Leu Ser Thr Leu Thr Gly Lys 
        115                 120                 125             


Asn Val Leu Ile Val Glu Asp Ile Ile Asp Thr Gly Lys Thr Met Gln 
    130                 135                 140                 


Thr Leu Leu Ser Leu Val Arg Gln Tyr Asn Pro Lys Met Val Lys Val 
145                 150                 155                 160 


Ala Ser Leu Leu Val Lys Arg Thr Pro Arg Ser Val Gly Tyr Lys Pro 
                165                 170                 175     


Asp Phe Val Gly Phe Glu Ile Pro Asp Lys Phe Val Val Gly Tyr Ala 
            180                 185                 190         


Leu Asp Tyr Asn Glu Tyr Phe Arg Asp Leu Asn His Val Cys Val Ile 
        195                 200                 205             


Ser Glu Thr Gly Lys Ala Lys Tyr Lys Ala 
    210                 215             


<210>  24
<211>  2271
<212>  DNA
<213>  Homo sapiens

<400>  24
atgtcgttcg tggcaggggt tattcggcgg ctggacgaga cagtggtgaa ccgcatcgcg       60

gcgggggaag ttatccagcg gccagctaat gctatcaaag agatgattga gaactgttta      120

gatgcaaaat ccacaagtat tcaagtgatt gttaaagagg gaggcctgaa gttgattcag      180

atccaagaca atggcaccgg gatcaggaaa gaagatctgg atattgtatg tgaaaggttc      240

actactagta aactgcagtc ctttgaggat ttagccagta tttctaccta tggctttcga      300

ggtgaggctt tggccagcat aagccatgtg gctcatgtta ctattacaac gaaaacagct      360

gatggaaagt gtgcatacag agcaagttac tcagatggaa aactgaaagc ccctcctaaa      420

ccatgtgctg gcaatcaagg gacccagatc acggtggagg acctttttta caacatagcc      480

acgaggagaa aagctttaaa aaatccaagt gaagaatatg ggaaaatttt ggaagttgtt      540

ggcaggtatt cagtacacaa tgcaggcatt agtttctcag ttaaaaaaca aggagagaca      600

gtagctgatg ttaggacact acccaatgcc tcaaccgtgg acaatattcg ctccatcttt      660

ggaaatgctg ttagtcgaga actgatagaa attggatgtg aggataaaac cctagccttc      720

aaaatgaatg gttacatatc caatgcaaac tactcagtga agaagtgcat cttcttactc      780

ttcatcaacc atcgtctggt agaatcaact tccttgagaa aagccataga aacagtgtat      840

gcagcctatt tgcccaaaaa cacacaccca ttcctgtacc tcagtttaga aatcagtccc      900

cagaatgtgg atgttaatgt gcaccccaca aagcatgaag ttcacttcct gcacgaggag      960

agcatcctgg agcgggtgca gcagcacatc gagagcaagc tcctgggctc caattcctcc     1020

aggatgtact tcacccagac tttgctacca ggacttgctg gcccctctgg ggagatggtt     1080

aaatccacaa caagtctgac ctcgtcttct acttctggaa gtagtgataa ggtctatgcc     1140

caccagatgg ttcgtacaga ttcccgggaa cagaagcttg atgcatttct gcagcctctg     1200

agcaaacccc tgtccagtca gccccaggcc attgtcacag aggataagac agatatttct     1260

agtggcaggg ctaggcagca agatgaggag atgcttgaac tcccagcccc tgctgaagtg     1320

gctgccaaaa atcagagctt ggagggggat acaacaaagg ggacttcaga aatgtcagag     1380

aagagaggac ctacttccag caaccccaga aagagacatc gggaagattc tgatgtggaa     1440

atggtggaag atgattcccg aaaggaaatg actgcagctt gtaccccccg gagaaggatc     1500

attaacctca ctagtgtttt gagtctccag gaagaaatta atgagcaggg acatgaggtt     1560

ctccgggaga tgttgcataa ccactccttc gtgggctgtg tgaatcctca gtgggccttg     1620

gcacagcatc aaaccaagtt ataccttctc aacaccacca agcttagtga agaactgttc     1680

taccagatac tcatttatga ttttgccaat tttggtgttc tcaggttatc ggagccagca     1740

ccgctctttg accttgccat gcttgcctta gatagtccag agagtggctg gacagaggaa     1800

gatggtccca aagaaggact tgctgaatac attgttgagt ttctgaagaa gaaggctgag     1860

atgcttgcag actatttctc tttggaaatt gatgaggaag ggaacctgat tggattaccc     1920

cttctgattg acaactatgt gccccctttg gagggactgc ctatcttcat tcttcgacta     1980

gccactgagg tgaattggga cgaagaaaag gaatgttttg aaagcctcag taaagaatgc     2040

gctatgttct attccatccg gaagcagtac atatctgagg agtcgaccct ctcaggccag     2100

cagagtgaag tgcctggctc cattccaaac tcctggaagt ggactgtgga acacattgtc     2160

tataaagcct tgcgctcaca cattctgcct cctaaacatt tcacagaaga tggaaatatc     2220

ctgcagcttg ctaacctgcc tgatctatac aaagtctttg agaggtgtta a              2271


<210>  25
<211>  2805
<212>  DNA
<213>  Homo sapiens

<400>  25
atggcggtgc agccgaagga gacgctgcag ttggagagcg cggccgaggt cggcttcgtg       60

cgcttctttc agggcatgcc ggagaagccg accaccacag tgcgcctttt cgaccggggc      120

gacttctata cggcgcacgg cgaggacgcg ctgctggccg cccgggaggt gttcaagacc      180

cagggggtga tcaagtacat ggggccggca ggagcaaaga atctgcagag tgttgtgctt      240

agtaaaatga attttgaatc ttttgtaaaa gatcttcttc tggttcgtca gtatagagtt      300

gaagtttata agaatagagc tggaaataag gcatccaagg agaatgattg gtatttggca      360

tataaggctt ctcctggcaa tctctctcag tttgaagaca ttctctttgg taacaatgat      420

atgtcagctt ccattggtgt tgtgggtgtt aaaatgtccg cagttgatgg ccagagacag      480

gttggagttg ggtatgtgga ttccatacag aggaaactag gactgtgtga attccctgat      540

aatgatcagt tctccaatct tgaggctctc ctcatccaga ttggaccaaa ggaatgtgtt      600

ttacccggag gagagactgc tggagacatg gggaaactga gacagataat tcaaagagga      660

ggaattctga tcacagaaag aaaaaaagct gacttttcca caaaagacat ttatcaggac      720

ctcaaccggt tgttgaaagg caaaaaggga gagcagatga atagtgctgt attgccagaa      780

atggagaatc aggttgcagt ttcatcactg tctgcggtaa tcaagttttt agaactctta      840

tcagatgatt ccaactttgg acagtttgaa ctgactactt ttgacttcag ccagtatatg      900

aaattggata ttgcagcagt cagagccctt aacctttttc agggttctgt tgaagatacc      960

actggctctc agtctctggc tgccttgctg aataagtgta aaacccctca aggacaaaga     1020

cttgttaacc agtggattaa gcagcctctc atggataaga acagaataga ggagagattg     1080

aatttagtgg aagcttttgt agaagatgca gaattgaggc agactttaca agaagattta     1140

cttcgtcgat tcccagatct taaccgactt gccaagaagt ttcaaagaca agcagcaaac     1200

ttacaagatt gttaccgact ctatcagggt ataaatcaac tacctaatgt tatacaggct     1260

ctggaaaaac atgaaggaaa acaccagaaa ttattgttgg cagtttttgt gactcctctt     1320

actgatcttc gttctgactt ctccaagttt caggaaatga tagaaacaac tttagatatg     1380

gatcaggtgg aaaaccatga attccttgta aaaccttcat ttgatcctaa tctcagtgaa     1440

ttaagagaaa taatgaatga cttggaaaag aagatgcagt caacattaat aagtgcagcc     1500

agagatcttg gcttggaccc tggcaaacag attaaactgg attccagtgc acagtttgga     1560

tattactttc gtgtaacctg taaggaagaa aaagtccttc gtaacaataa aaactttagt     1620

actgtagata tccagaagaa tggtgttaaa tttaccaaca gcaaattgac ttctttaaat     1680

gaagagtata ccaaaaataa aacagaatat gaagaagccc aggatgccat tgttaaagaa     1740

attgtcaata tttcttcagg ctatgtagaa ccaatgcaga cactcaatga tgtgttagct     1800

cagctagatg ctgttgtcag ctttgctcac gtgtcaaatg gagcacctgt tccatatgta     1860

cgaccagcca ttttggagaa aggacaagga agaattatat taaaagcatc caggcatgct     1920

tgtgttgaag ttcaagatga aattgcattt attcctaatg acgtatactt tgaaaaagat     1980

aaacagatgt tccacatcat tactggcccc aatatgggag gtaaatcaac atatattcga     2040

caaactgggg tgatagtact catggcccaa attgggtgtt ttgtgccatg tgagtcagca     2100

gaagtgtcca ttgtggactg catcttagcc cgagtagggg ctggtgacag tcaattgaaa     2160

ggagtctcca cgttcatggc tgaaatgttg gaaactgctt ctatcctcag gtctgcaacc     2220

aaagattcat taataatcat agatgaattg ggaagaggaa cttctaccta cgatggattt     2280

gggttagcat gggctatatc agaatacatt gcaacaaaga ttggtgcttt ttgcatgttt     2340

gcaacccatt ttcatgaact tactgccttg gccaatcaga taccaactgt taataatcta     2400

catgtcacag cactcaccac tgaagagacc ttaactatgc tttatcaggt gaagaaaggt     2460

gtctgtgatc aaagttttgg gattcatgtt gcagagcttg ctaatttccc taagcatgta     2520

atagagtgtg ctaaacagaa agccctggaa cttgaggagt ttcagtatat tggagaatcg     2580

caaggatatg atatcatgga accagcagca aagaagtgct atctggaaag agagcaaggt     2640

gaaaaaatta ttcaggagtt cctgtccaag gtgaaacaaa tgccctttac tgaaatgtca     2700

gaagaaaaca tcacaataaa gttaaaacag ctaaaagctg aagtaatagc aaagaataat     2760

agctttgtaa atgaaatcat ttcacgaata aaagttacta cgtga                     2805


<210>  26
<211>  4244
<212>  DNA
<213>  Homo sapiens

<400>  26
gccgcgcggt agatgcggtg cttttaggag ctccgtccga cagaacggtt gggccttgcc       60

ggctgtcggt atgtcgcgac agagcaccct gtacagcttc ttccccaagt ctccggcgct      120

gagtgatgcc aacaaggcct cggccagggc ctcacgcgaa ggcggccgtg ccgccgctgc      180

ccccggggcc tctccttccc caggcgggga tgcggcctgg agcgaggctg ggcctgggcc      240

caggcccttg gcgcgctccg cgtcaccgcc caaggcgaag aacctcaacg gagggctgcg      300

gagatcggta gcgcctgctg cccccaccag ttgtgacttc tcaccaggag atttggtttg      360

ggccaagatg gagggttacc cctggtggcc ttgtctggtt tacaaccacc cctttgatgg      420

aacattcatc cgcgagaaag ggaaatcagt ccgtgttcat gtacagtttt ttgatgacag      480

cccaacaagg ggctgggtta gcaaaaggct tttaaagcca tatacaggtt caaaatcaaa      540

ggaagcccag aagggaggtc atttttacag tgcaaagcct gaaatactga gagcaatgca      600

acgtgcagat gaagccttaa ataaagacaa gattaagagg cttgaattgg cagtttgtga      660

tgagccctca gagccagaag aggaagaaga gatggaggta ggcacaactt acgtaacaga      720

taagagtgaa gaagataatg aaattgagag tgaagaggaa gtacagccta agacacaagg      780

atctaggcga agtagccgcc aaataaaaaa acgaagggtc atatcagatt ctgagagtga      840

cattggtggc tctgatgtgg aatttaagcc agacactaag gaggaaggaa gcagtgatga      900

aataagcagt ggagtggggg atagtgagag tgaaggcctg aacagccctg tcaaagttgc      960

tcgaaagcgg aagagaatgg tgactggaaa tggctctctt aaaaggaaaa gctctaggaa     1020

ggaaacgccc tcagccacca aacaagcaac tagcatttca tcagaaacca agaatacttt     1080

gagagctttc tctgcccctc aaaattctga atcccaagcc cacgttagtg gaggtggtga     1140

tgacagtagt cgccctactg tttggtatca tgaaacttta gaatggctta aggaggaaaa     1200

gagaagagat gagcacagga ggaggcctga tcaccccgat tttgatgcat ctacactcta     1260

tgtgcctgag gatttcctca attcttgtac tcctgggatg aggaagtggt ggcagattaa     1320

gtctcagaac tttgatcttg tcatctgtta caaggtgggg aaattttatg agctgtacca     1380

catggatgct cttattggag tcagtgaact ggggctggta ttcatgaaag gcaactgggc     1440

ccattctggc tttcctgaaa ttgcatttgg ccgttattca gattccctgg tgcagaaggg     1500

ctataaagta gcacgagtgg aacagactga gactccagaa atgatggagg cacgatgtag     1560

aaagatggca catatatcca agtatgatag agtggtgagg agggagatct gtaggatcat     1620

taccaagggt acacagactt acagtgtgct ggaaggtgat ccctctgaga actacagtaa     1680

gtatcttctt agcctcaaag aaaaagagga agattcttct ggccatactc gtgcatatgg     1740

tgtgtgcttt gttgatactt cactgggaaa gtttttcata ggtcagtttt cagatgatcg     1800

ccattgttcg agatttagga ctctagtggc acactatccc ccagtacaag ttttatttga     1860

aaaaggaaat ctctcaaagg aaactaaaac aattctaaag agttcattgt cctgttctct     1920

tcaggaaggt ctgatacccg gctcccagtt ttgggatgca tccaaaactt tgagaactct     1980

ccttgaggaa gaatatttta gggaaaagct aagtgatggc attggggtga tgttacccca     2040

ggtgcttaaa ggtatgactt cagagtctga ttccattggg ttgacaccag gagagaaaag     2100

tgaattggcc ctctctgctc taggtggttg tgtcttctac ctcaaaaaat gccttattga     2160

tcaggagctt ttatcaatgg ctaattttga agaatatatt cccttggatt ctgacacagt     2220

cagcactaca agatctggtg ctatcttcac caaagcctat caacgaatgg tgctagatgc     2280

agtgacatta aacaacttgg agatttttct gaatggaaca aatggttcta ctgaaggaac     2340

cctactagag agggttgata cttgccatac tccttttggt aagcggctcc taaagcaatg     2400

gctttgtgcc ccactctgta accattatgc tattaatgat cgtctagatg ccatagaaga     2460

cctcatggtt gtgcctgaca aaatctccga agttgtagag cttctaaaga agcttccaga     2520

tcttgagagg ctactcagta aaattcataa tgttgggtct cccctgaaga gtcagaacca     2580

cccagacagc agggctataa tgtatgaaga aactacatac agcaagaaga agattattga     2640

ttttctttct gctctggaag gattcaaagt aatgtgtaaa attataggga tcatggaaga     2700

agttgctgat ggttttaagt ctaaaatcct taagcaggtc atctctctgc agacaaaaaa     2760

tcctgaaggt cgttttcctg atttgactgt agaattgaac cgatgggata cagcctttga     2820

ccatgaaaag gctcgaaaga ctggacttat tactcccaaa gcaggctttg actctgatta     2880

tgaccaagct cttgctgaca taagagaaaa tgaacagagc ctcctggaat acctagagaa     2940

acagcgcaac agaattggct gtaggaccat agtctattgg gggattggta ggaaccgtta     3000

ccagctggaa attcctgaga atttcaccac tcgcaatttg ccagaagaat acgagttgaa     3060

atctaccaag aagggctgta aacgatactg gaccaaaact attgaaaaga agttggctaa     3120

tctcataaat gctgaagaac ggagggatgt atcattgaag gactgcatgc ggcgactgtt     3180

ctataacttt gataaaaatt acaaggactg gcagtctgct gtagagtgta tcgcagtgtt     3240

ggatgtttta ctgtgcctgg ctaactatag tcgagggggt gatggtccta tgtgtcgccc     3300

agtaattctg ttgccggaag ataccccccc cttcttagag cttaaaggat cacgccatcc     3360

ttgcattacg aagacttttt ttggagatga ttttattcct aatgacattc taataggctg     3420

tgaggaagag gagcaggaaa atggcaaagc ctattgtgtg cttgttactg gaccaaatat     3480

ggggggcaag tctacgctta tgagacaggc tggcttatta gctgtaatgg cccagatggg     3540

ttgttacgtc cctgctgaag tgtgcaggct cacaccaatt gatagagtgt ttactagact     3600

tggtgcctca gacagaataa tgtcaggtga aagtacattt tttgttgaat taagtgaaac     3660

tgccagcata ctcatgcatg caacagcaca ttctctggtg cttgtggatg aattaggaag     3720

aggtactgca acatttgatg ggacggcaat agcaaatgca gttgttaaag aacttgctga     3780

gactataaaa tgtcgtacat tattttcaac tcactaccat tcattagtag aagattattc     3840

tcaaaatgtt gctgtgcgcc taggacatat ggcatgcatg gtagaaaatg aatgtgaaga     3900

ccccagccag gagactatta cgttcctcta taaattcatt aagggagctt gtcctaaaag     3960

ctatggcttt aatgcagcaa ggcttgctaa tctcccagag gaagttattc aaaagggaca     4020

tagaaaagca agagaatttg agaagatgaa tcagtcacta cgattatttc gggaagtttg     4080

cctggctagt gaaaggtcaa ctgtagatgc tgaagctgtc cataaattgc tgactttgat     4140

taaggaatta tagactgact acattggaag ctttgagttg acttctgaca aaggtggtaa     4200

attcagacaa cattatgatc taataaactt tattttttaa aaat                      4244


<210>  27
<211>  2589
<212>  DNA
<213>  Homo sapiens

<400>  27
atggagcgag ctgagagctc gagtacagaa cctgctaagg ccatcaaacc tattgatcgg       60

aagtcagtcc atcagatttg ctctgggcag gtggtactga gtctaagcac tgcggtaaag      120

gagttagtag aaaacagtct ggatgctggt gccactaata ttgatctaaa gcttaaggac      180

tatggagtgg atcttattga agtttcagac aatggatgtg gggtagaaga agaaaacttc      240

gaaggcttaa ctctgaaaca tcacacatct aagattcaag agtttgccga cctaactcag      300

gttgaaactt ttggctttcg gggggaagct ctgagctcac tttgtgcact gagcgatgtc      360

accatttcta cctgccacgc atcggcgaag gttggaactc gactgatgtt tgatcacaat      420

gggaaaatta tccagaaaac cccctacccc cgccccagag ggaccacagt cagcgtgcag      480

cagttatttt ccacactacc tgtgcgccat aaggaatttc aaaggaatat taagaaggag      540

tatgccaaaa tggtccaggt cttacatgca tactgtatca tttcagcagg catccgtgta      600

agttgcacca atcagcttgg acaaggaaaa cgacagcctg tggtatgcac aggtggaagc      660

cccagcataa aggaaaatat cggctctgtg tttgggcaga agcagttgca aagcctcatt      720

ccttttgttc agctgccccc tagtgactcc gtgtgtgaag agtacggttt gagctgttcc      780

gatgctctgc ataatctttt ttacatctca ggtttcattt cacaatgcac gcatggagtt      840

ggaaggagtt caacagacag acagtttttc tttatcaacc ggcggccttg tgacccagca      900

aaggtctgca gactcgtgaa tgaggtctac cacatgtata atcgacacca gtatccattt      960

gttgttctta acatttctgt tgattcagaa tgcgttgata tcaatgttac tccagataaa     1020

aggcaaattt tgctacaaga ggaaaagctt ttgttggcag ttttaaagac ctctttgata     1080

ggaatgtttg atagtgatgt caacaagcta aatgtcagtc agcagccact gctggatgtt     1140

gaaggtaact taataaaaat gcatgcagcg gatttggaaa agcccatggt agaaaagcag     1200

gatcaatccc cttcattaag gactggagaa gaaaaaaaag acgtgtccat ttccagactg     1260

cgagaggcct tttctcttcg tcacacaaca gagaacaagc ctcacagccc aaagactcca     1320

gaaccaagaa ggagccctct aggacagaaa aggggtatgc tgtcttctag cacttcaggt     1380

gccatctctg acaaaggcgt cctgagacct cagaaagagg cagtgagttc cagtcacgga     1440

cccagtgacc ctacggacag agcggaggtg gagaaggact cggggcacgg cagcacttcc     1500

gtggattctg aggggttcag catcccagac acgggcagtc actgcagcag cgagtatgcg     1560

gccagctccc caggggacag gggctcgcag gaacatgtgg actctcagga gaaagcgcct     1620

aaaactgacg actctttttc agatgtggac tgccattcaa accaggaaga taccggatgt     1680

aaatttcgag ttttgcctca gccaactaat ctcgcaaccc caaacacaaa gcgttttaaa     1740

aaagaagaaa ttctttccag ttctgacatt tgtcaaaagt tagtaaatac tcaggacatg     1800

tcagcctctc aggttgatgt agctgtgaaa attaataaga aagttgtgcc cctggacttt     1860

tctatgagtt ctttagctaa acgaataaag cagttacatc atgaagcaca gcaaagtgaa     1920

ggggaacaga attacaggaa gtttagggca aagatttgtc ctggagaaaa tcaagcagcc     1980

gaagatgaac taagaaaaga gataagtaaa acgatgtttg cagaaatgga aatcattggt     2040

cagtttaacc tgggatttat aataaccaaa ctgaatgagg atatcttcat agtggaccag     2100

catgccacgg acgagaagta taacttcgag atgctgcagc agcacaccgt gctccagggg     2160

cagaggctca tagcacctca gactctcaac ttaactgctg ttaatgaagc tgttctgata     2220

gaaaatctgg aaatatttag aaagaatggc tttgattttg ttatcgatga aaatgctcca     2280

gtcactgaaa gggctaaact gatttccttg ccaactagta aaaactggac cttcggaccc     2340

caggacgtcg atgaactgat cttcatgctg agcgacagcc ctggggtcat gtgccggcct     2400

tcccgagtca agcagatgtt tgcctccaga gcctgccgga agtcggtgat gattgggact     2460

gctcttaaca caagcgagat gaagaaactg atcacccaca tgggggagat ggaccacccc     2520

tggaactgtc cccatggaag gccaaccatg agacacatcg ccaacctggg tgtcatttct     2580

cagaactga                                                             2589


