                         б

<110>  ҩƷ޹˾
 
<120>  PD-1/HER2ȻṹԴʽ˫쿹弰Ʊ

<130>  LZ1605857CN01

<160>  18    

<170>  PatentIn version 3.3

<210>  1
<211>  321
<212>  DNA
<213>  ˹УArtificial

<220>
<223>  ɱ

<400>  1
gacattcaga tgactcagag cccttcttca ctgtcagctt ccgtgggcga cagagtcact     60

atcacctgcc gcgcaagtca ggatgtgaac accgcagtcg cctggtacca gcagaagcct    120

ggcaaagctc caaagctgct gatctacagc gcatctttcc tgtattctgg agtgcccagt    180

aggtttagtg ggtcacggtc cggtaccgac ttcacactga ctatctccag cctgcagcct    240

gaggattttg ccacatacta ttgccagcag cactatacca caccccctac tttcggccag    300

ggaaccaaag tggagatcaa g                                              321


<210>  2
<211>  107
<212>  PRT
<213>  ˹УArtificial

<220>
<223>  ɱ

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  3
<211>  321
<212>  DNA
<213>  ˹УArtificial

<220>
<223>  㶨

<400>  3
cgaactgtgg ccgctccaag cgtcttcatt tttccaccct ctgacgaaca gctgaagtca     60

gggacagctt ccgtggtctg tctgctgaac aatttttacc ccagggaggc caaagtgcag    120

tggaaggtcg ataacgctct gcagagcgga aattctcagg agagtgtgac agaacaggac    180

tcaaaagatt ccacttatag cctgtctagt accctgacac tgtccaaggc agactacgaa    240

aagcataaag tgtatgcctg tgaggtcaca catcagggtc tgtcaagccc cgtcactaag    300

tccttcaatc gtggcgaatg c                                              321


<210>  4
<211>  107
<212>  PRT
<213>  ˹УArtificial

<220>
<223>  㶨

<400>  4

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  5
<211>  360
<212>  DNA
<213>  ˹УArtificial

<220>
<223>  ɱ

<400>  5
gaggtgcagc tggtcgaaag tgggggtggg ctggtgcagc caggcggatc actgaggctg     60

tcctgcgccg ctagcggctt caacatcaaa gacacctata ttcactgggt ccgacaggca    120

ccagggaagg gtctggaatg ggtggctcgt atctacccta caaatggtta cactagatat    180

gccgactccg tgaaaggccg gtttactatt tctgctgata ccagtaagaa cacagcatac    240

ctgcagatga atagcctgag ggctgaggat accgcagtgt actattgctc tcggtggggg    300

ggtgacggct tctacgctat ggattattgg ggccagggaa ctctggtcac cgtgtccagc    360


<210>  6
<211>  120
<212>  PRT
<213>  ˹УArtificial

<220>
<223>  ɱ

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  7
<211>  990
<212>  DNA
<213>  ˹УArtificial

<220>
<223>  㶨

<400>  7
gcttcaacaa aaggaccttc cgtgtttcca ctggcaccct ctagtaagag tacttcagga     60

ggaaccgcag cactgggatg tctggtgaag gactacttcc cagagcccgt caccgtgtct    120

tggaacagtg gagcactgac ctccggggtc catacatttc ctgccgtgct gcagtcatcc    180

ggtctgtata gcctgagctc tgtggtcaca gtcccaagtt catccctggg cacccagaca    240

tacatctgca acgtgaatca caaaccttcc aatactaagg tcgacaagaa agtggaacca    300

aaaagctgtg ataagactca tacctgccca ccttgtcctg caccagagct gctgggaggt    360

ccaagcgtgt tcctgtttcc acccaagccc aaagacacac tgatgatttc tcgcacaccc    420

gaagtcactt gtgtggtcgt ggacgtgtcc cacgaggatc ctgaagtcaa gttcaactgg    480

tacgtggatg gcgtcgaggt gcataatgct aagaccaaac ccagagagga acagtacaac    540

agcacctatc gcgtcgtgtc tgtcctgaca gtgctgcacc aggattggct gaacggaaag    600

gagtacaagt gcaaagtgag caacaaggcc ctgcccgctc ctatcgagaa gaccatttct    660

aaggctaaag gccagcctag agaaccacag gtgtatacag agcctccaag tcgcgacgag    720

ctgacaaaaa accaggtctc cctgacttgt ctggtgaagg gattctaccc tagcgatatc    780

gcagtggagt gggaatctaa tgggcagcca gaaaacaatt ataagaccac accccctgtg    840

ctggactcag atggttcctt ctttctgctg agtgtgctga ccgtggacaa gtccaggtgg    900

cagcagggga acgtcttttc ctgcagcgtg atgcatgagg ccctgcacaa tcattacaca    960

cagaaatctc tgagtctgtc accaggaaag                                     990


<210>  8
<211>  330
<212>  PRT
<213>  ˹УArtificial

<220>
<223>  㶨

<400>  8

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Glu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Leu Ser Val Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  9
<211>  333
<212>  DNA
<213>  ˹УArtificial

<220>
<223>  ɱ

<400>  9
gagatcgtgc tgacccagag ccctgccaca ctgagcctga gccctggcga aagggccacc     60

ctgagctgca gggctagcaa gggcgtgagc accagcggct acagctacct gcactggtat    120

caacagaagc ccggccaggc tcctaggctg ctgatctacc tggccagcta tctggagagc    180

ggcgtgcccg ctagattcag cggaagcggc agcggcaccg acttcaccct gaccatcagc    240

agcctggagc ccgaggactt cgccgtgtac tactgccagc acagcaggga cctgcctctg    300

accttcggag gcggcaccaa ggtggagatc aag                                 333


<210>  10
<211>  111
<212>  PRT
<213>  ˹УArtificial

<220>
<223>  ɱ

<400>  10

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  11
<211>  360
<212>  DNA
<213>  ˹УArtificial

<220>
<223>  ɱ

<400>  11
caggtgcagc tggtgcagag cggcgtggag gtgaagaagc ctggcgccag cgtgaaggtg     60

agctgcaagg ccagcggcta caccttcacc aactactaca tgtactgggt gaggcaggcc    120

cctggccaag gactggagtg gatgggcggc atcaacccca gcaacggcgg caccaacttc    180

aacgagaagt tcaagaacag ggtgaccctg accaccgaca gcagcaccac caccgcctac    240

atggagctga agagcctgca gttcgacgac accgccgtgt actactgcgc caggagggac    300

tacaggttcg acatgggctt cgactactgg ggccagggca ccacagtgac cgtgtccagc    360


<210>  12
<211>  120
<212>  PRT
<213>  ˹УArtificial

<220>
<223>  ɱ

<400>  12

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  13
<211>  990
<212>  DNA
<213>  ˹УArtificial

<220>
<223>  㶨

<400>  13
gcttcaacaa aaggaccttc cgtgtttcca ctggcaccct ctagtaagag tacttcagga     60

ggaaccgcag cactgggatg tctggtgaag gactacttcc cagagcccgt caccgtgtct    120

tggaacagtg gagcactgac ctccggggtc catacatttc ctgccgtgct gcagtcatcc    180

ggtctgtata gcctgagctc tgtggtcaca gtcccaagtt catccctggg cacccagaca    240

tacatctgca acgtgaatca caaaccttcc aatactaagg tcgacaagaa agtggaacca    300

aaaagctgtg ataagactca tacctgccca ccttgtcctg caccagagct gctgggaggt    360

ccaagcgtgt tcctgtttcc acccaagccc aaagacacac tgatgatttc tcgcacaccc    420

gaagtcactt gtgtggtcgt ggacgtgtcc cacgaggatc ctgaagtcaa gttcaactgg    480

tacgtggatg gcgtcgaggt gcataatgct aagaccaaac ccagagagga acagtacaac    540

agcacctatc gcgtcgtgtc tgtcctgaca gtgctgcacc aggattggct gaacggaaag    600

gagtacaagt gcaaagtgag caacaaggcc ctgcccgctc ctatcgagaa gaccatttct    660

aaggctaaag gccagcctag agaaccacag gtgtatacac tgcctccaag tcgcgacgag    720

ctgacaaaaa accaggtctc cctgctgtgt ctggtgaagg gattctaccc tagcgatatc    780

gcagtggagt gggaatctaa tgggcagcca gaaaacaatt ataagaccac accccctgtg    840

ctgcggtcag atggttcctt ctttctgtac agtaaactga ccgtggacaa gtccaggtgg    900

cagcagggga acgtcttttc ctgcagcgtg atgcatgagg ccctgcacaa tcattacaca    960

cagaaatctc tgagtctgtc accaggaaag                                     990


<210>  14
<211>  330
<212>  PRT
<213>  ˹УArtificial

<220>
<223>  㶨

<400>  14

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Arg Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  15
<211>  321
<212>  DNA
<213>  ˹УArtificial

<220>
<223>  ɱ

<400>  15
gatatcgttc tcacccagtc tccagccacc ctgtctgtga ctccaggaga tagcgtcagt     60

ctttcctgca gggccaacca aagtattagc aacaacctac actggtatca acaaagatca    120

catgagtctc cgaggcttct catcagattt gcttcccagt ccatctctgg gatcccctcc    180

aggttcagtg gcagtggatc agggacagat ttcactctca gtatcaacag tgtggagact    240

gaagattttg gaatgtattt ctgtcaacag agtgacaact ggcctctcac gttcggtgct    300

gggaccaagc tggagatcaa g                                              321


<210>  16
<211>  107
<212>  PRT
<213>  ˹УArtificial

<220>
<223>  ɱ

<400>  16

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Asn Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Arg Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Arg Phe Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asp Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  17
<211>  351
<212>  DNA
<213>  ˹УArtificial

<220>
<223>  ɱ

<400>  17
gaggttcagc tgcaggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc     60

tcctgtgcag cctctggatt cactttcagt agctatggca tgtcttgggt tcgccagact    120

ccggagaaga ggctggagtg ggtcgcaagc attagtggtg gtggtcgtta tacctactat    180

ccagacagta tgaaggggcg attcaccatc tccagagaca atgccaagaa caacctgcac    240

ctgcaaatga gcagtctgag gtctgaggac acggccttgt attactgtgt ctatgaatat    300

ttttatacta tggactactg gggtcaagga acctcagtca ccgtctcctc a             351


<210>  18
<211>  117
<212>  PRT
<213>  ˹УArtificial

<220>
<223>  ɱ

<400>  18

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Gly Gly Gly Arg Tyr Thr Tyr Tyr Pro Asp Ser Met 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu His 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Tyr Glu Tyr Phe Tyr Thr Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


