                         SEQUENCE LISTING

<110>  Translate Bio, Inc.
 
<120>  IMPROVED ICE-BASED LIPID NANOPARTICLE FORMULATION FOR DELIVERY OF 
       MRNA

<130>  MRT-1247WO

<150>  62/420,421
<151>  2016-11-10

<150>  62/420,428
<151>  2016-11-10

<150>  62/421,021
<151>  2016-11-11

<150>  62/421,007
<151>  2016-11-11

<150>  62/464,327
<151>  2017-02-27

<150>  62/464,330
<151>  2017-02-27

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  4443
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized oligonucleotide

<400>  1
augcaacgcu cuccucuuga aaaggccucg guggugucca agcucuucuu cucguggacu       60

agacccaucc ugagaaaggg guacagacag cgcuuggagc uguccgauau cuaucaaauc      120

ccuuccgugg acuccgcgga caaccugucc gagaagcucg agagagaaug ggacagagaa      180

cucgccucaa agaagaaccc gaagcugauu aaugcgcuua ggcggugcuu uuucuggcgg      240

uucauguucu acggcaucuu ccucuaccug ggagagguca ccaaggccgu gcagccccug      300

uugcugggac ggauuauugc cuccuacgac cccgacaaca aggaagaaag aagcaucgcu      360

aucuacuugg gcaucggucu gugccugcuu uucaucgucc ggacccucuu guugcauccu      420

gcuauuuucg gccugcauca cauuggcaug cagaugagaa uugccauguu uucccugauc      480

uacaagaaaa cucugaagcu cucgagccgc gugcuugaca agauuuccau cggccagcuc      540

gugucccugc ucuccaacaa ucugaacaag uucgacgagg gccucgcccu ggcccacuuc      600

guguggaucg ccccucugca aguggcgcuu cugaugggcc ugaucuggga gcugcugcaa      660

gccucggcau ucugugggcu uggauuccug aucgugcugg cacuguucca ggccggacug      720

gggcggauga ugaugaagua cagggaccag agagccggaa agauuuccga acggcuggug      780

aucacuucgg aaaugaucga aaacauccag ucagugaagg ccuacugcug ggaagaggcc      840

auggaaaaga ugauugaaaa ccuccggcaa accgagcuga agcugacccg caaggccgcu      900

uacgugcgcu auuucaacuc guccgcuuuc uucuucuccg gguucuucgu gguguuucuc      960

uccgugcucc ccuacgcccu gauuaaggga aucauccuca ggaagaucuu caccaccauu     1020

uccuucugua ucgugcuccg cauggccgug acccggcagu ucccaugggc cgugcagacu     1080

ugguacgacu cccugggagc cauuaacaag auccaggacu uccuucaaaa gcaggaguac     1140

aagacccucg aguacaaccu gacuacuacc gaggucguga uggaaaacgu caccgccuuu     1200

ugggaggagg gauuuggcga acuguucgag aaggccaagc agaacaacaa caaccgcaag     1260

accucgaacg gugacgacuc ccucuucuuu ucaaacuuca gccugcucgg gacgcccgug     1320

cugaaggaca uuaacuucaa gaucgaaaga ggacagcucc uggcgguggc cggaucgacc     1380

ggagccggaa agacuucccu gcugauggug aucaugggag agcuugaacc uagcgaggga     1440

aagaucaagc acuccggccg caucagcuuc uguagccagu uuuccuggau caugcccgga     1500

accauuaagg aaaacaucau cuucggcgug uccuacgaug aauaccgcua ccgguccgug     1560

aucaaagccu gccagcugga agaggauauu ucaaaguucg cggagaaaga uaacaucgug     1620

cugggcgaag gggguauuac cuugucgggg ggccagcggg cuagaaucuc gcuggccaga     1680

gccguguaua aggacgccga ccuguaucuc cuggacuccc ccuucggaua ccuggacguc     1740

cugaccgaaa aggagaucuu cgaaucgugc gugugcaagc ugauggcuaa caagacucgc     1800

auccucguga ccuccaaaau ggagcaccug aagaaggcag acaagauucu gauucugcau     1860

gagggguccu ccuacuuuua cggcaccuuc ucggaguugc agaacuugca gcccgacuuc     1920

ucaucgaagc ugauggguug cgacagcuuc gaccaguucu ccgccgaaag aaggaacucg     1980

auccugacgg aaaccuugca ccgcuucucu uuggaaggcg acgccccugu gucauggacc     2040

gagacuaaga agcagagcuu caagcagacc ggggaauucg gcgaaaagag gaagaacagc     2100

aucuugaacc ccauuaacuc cauccgcaag uucucaaucg ugcaaaagac gccacugcag     2160

augaacggca uugaggagga cuccgacgaa ccccuugaga ggcgccuguc ccuggugccg     2220

gacagcgagc agggagaagc cauccugccu cggauuuccg ugaucuccac ugguccgacg     2280

cuccaagccc ggcggcggca guccgugcug aaccugauga cccacagcgu gaaccagggc     2340

caaaacauuc accgcaagac uaccgcaucc acccggaaag ugucccuggc accucaagcg     2400

aaucuuaccg agcucgacau cuacucccgg agacugucgc aggaaaccgg gcucgaaauu     2460

uccgaagaaa ucaacgagga ggaucugaaa gagugcuucu ucgacgauau ggagucgaua     2520

cccgccguga cgacuuggaa cacuuaucug cgguacauca cugugcacaa gucauugauc     2580

uucgugcuga uuuggugccu ggugauuuuc cuggccgagg ucgcggccuc acugguggug     2640

cucuggcugu ugggaaacac gccucugcaa gacaagggaa acuccacgca cucgagaaac     2700

aacagcuaug ccgugauuau cacuuccacc uccucuuauu acguguucua caucuacguc     2760

ggaguggcgg auacccugcu cgcgaugggu uucuucagag gacugccgcu gguccacacc     2820

uugaucaccg ucagcaagau ucuucaccac aagauguugc auagcgugcu gcaggccccc     2880

auguccaccc ucaacacucu gaaggccgga ggcauucuga acagauucuc caaggacauc     2940

gcuauccugg acgaucuccu gccgcuuacc aucuuugacu ucauccagcu gcugcugauc     3000

gugauuggag caaucgcagu gguggcggug cugcagccuu acauuuucgu ggccacugug     3060

ccggucauug uggcguucau caugcugcgg gccuacuucc uccaaaccag ccagcagcug     3120

aagcaacugg aauccgaggg acgauccccc aucuucacuc accuugugac gucguugaag     3180

ggacugugga cccuccgggc uuucggacgg cagcccuacu ucgaaacccu cuuccacaag     3240

gcccugaacc uccacaccgc caauugguuc cuguaccugu ccacccugcg gugguuccag     3300

augcgcaucg agaugauuuu cgucaucuuc uucaucgcgg ucacauucau cagcauccug     3360

acuaccggag agggagaggg acgggucgga auaauccuga cccucgccau gaacauuaug     3420

agcacccugc agugggcagu gaacagcucg aucgacgugg acagccugau gcgaagcguc     3480

agccgcgugu ucaaguucau cgacaugccu acugagggaa aacccacuaa guccacuaag     3540

cccuacaaaa auggccagcu gagcaagguc augaucaucg aaaacuccca cgugaagaag     3600

gacgauauuu ggcccuccgg aggucaaaug accgugaagg accugaccgc aaaguacacc     3660

gagggaggaa acgccauucu cgaaaacauc agcuucucca uuucgccggg acagcggguc     3720

ggccuucucg ggcggaccgg uuccgggaag ucaacucugc ugucggcuuu ccuccggcug     3780

cugaauaccg agggggaaau ccaaauugac ggcgugucuu gggauuccau uacucugcag     3840

caguggcgga aggccuucgg cgugaucccc cagaaggugu ucaucuucuc ggguaccuuc     3900

cggaagaacc uggauccuua cgagcagugg agcgaccaag aaaucuggaa ggucgccgac     3960

gaggucggcc ugcgcuccgu gauugaacaa uuuccuggaa agcuggacuu cgugcucguc     4020

gacgggggau guguccuguc gcacggacau aagcagcuca ugugccucgc acgguccgug     4080

cucuccaagg ccaagauucu gcugcuggac gaaccuucgg cccaccugga uccggucacc     4140

uaccagauca ucaggaggac ccugaagcag gccuuugccg auugcaccgu gauucucugc     4200

gagcaccgca ucgaggccau gcuggagugc cagcaguucc uggucaucga ggagaacaag     4260

guccgccaau acgacuccau ucaaaagcuc cucaacgagc ggucgcuguu cagacaagcu     4320

auuucaccgu ccgauagagu gaagcucuuc ccgcaucgga acagcucaaa gugcaaaucg     4380

aagccgcaga ucgcagccuu gaaggaagag acugaggaag aggugcagga cacccggcuu     4440

uaa                                                                   4443


<210>  2
<211>  4443
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized oligonucleotide

<400>  2
augcagcggu ccccgcucga aaaggccagu gucgugucca aacucuucuu cucauggacu       60

cggccuaucc uuagaaaggg guaucggcag aggcuugagu ugucugacau cuaccagauc      120

cccucgguag auucggcgga uaaccucucg gagaagcucg aacgggaaug ggaccgcgaa      180

cucgcgucua agaaaaaccc gaagcucauc aacgcacuga gaaggugcuu cuucuggcgg      240

uucauguucu acgguaucuu cuuguaucuc ggggagguca caaaagcagu ccaaccccug      300

uuguuggguc gcauuaucgc cucguacgac cccgauaaca aagaagaacg gagcaucgcg      360

aucuaccucg ggaucggacu guguuugcuu uucaucguca gaacacuuuu guugcaucca      420

gcaaucuucg gccuccauca caucgguaug cagaugcgaa ucgcuauguu uagcuugauc      480

uacaaaaaga cacugaaacu cucgucgcgg guguuggaua agauuuccau cggucaguug      540

gugucccugc uuaguaauaa ccucaacaaa uucgaugagg gacuggcgcu ggcacauuuc      600

guguggauug ccccguugca agucgcccuu uugaugggcc uuauuuggga gcuguugcag      660

gcaucugccu uuuguggccu gggauuucug auuguguugg cauuguuuca ggcugggcuu      720

gggcggauga ugaugaagua ucgcgaccag agagcgggua aaaucucgga aagacucguc      780

aucacuucgg aaaugaucga aaacauccag ucggucaaag ccuauugcug ggaagaagcu      840

auggagaaga ugauugaaaa ccuccgccaa acugagcuga aacugacccg caaggcggcg      900

uauguccggu auuucaauuc gucagcguuc uucuuuuccg gguucuucgu ugucuuucuc      960

ucgguuuugc cuuaugccuu gauuaagggg auuauccucc gcaagauuuu caccacgauu     1020

ucguucugca uuguauugcg cauggcagug acacggcaau uuccgugggc cgugcagaca     1080

ugguaugacu cgcuuggagc gaucaacaaa auccaagacu ucuugcaaaa gcaagaguac     1140

aagacccugg aguacaaucu uacuacuacg gagguaguaa uggagaaugu gacggcuuuu     1200

ugggaagagg guuuuggaga acuguuugag aaagcaaagc agaauaacaa caaccgcaag     1260

accucaaaug gggacgauuc ccuguuuuuc ucgaacuucu cccugcucgg aacacccgug     1320

uugaaggaca ucaauuucaa gauugagagg ggacagcuuc ucgcgguagc gggaagcacu     1380

ggugcgggaa aaacuagccu cuugauggug auuauggggg agcuugagcc cagcgagggg     1440

aagauuaaac acuccgggcg uaucucauuc uguagccagu uuucauggau caugcccgga     1500

accauuaaag agaacaucau uuucggagua uccuaugaug aguaccgaua cagaucgguc     1560

auuaaggcgu gccaguugga agaggacauu ucuaaguucg ccgagaagga uaacaucguc     1620

uugggagaag gggguauuac auugucggga gggcagcgag cgcggaucag ccucgcgaga     1680

gcgguauaca aagaugcaga uuuguaucug cuugauucac cguuuggaua ccucgacgua     1740

uugacagaaa aagaaaucuu cgagucgugc guguguaaac uuauggcuaa uaagacgaga     1800

auccugguga caucaaaaau ggaacaccuu aagaaggcgg acaagauccu gauccuccac     1860

gaaggaucgu ccuacuuuua cggcacuuuc ucagaguugc aaaacuugca gccggacuuc     1920

ucaagcaaac ucauggggug ugacucauuc gaccaguuca gcgcggaacg gcggaacucg     1980

aucuugacgg aaacgcugca ccgauucucg cuugagggug augccccggu aucguggacc     2040

gagacaaaga agcagucguu uaagcagaca ggagaauuug gugagaaaag aaagaacagu     2100

aucuugaauc cuauuaacuc aauucgcaag uucucaaucg uccagaaaac uccacugcag     2160

augaauggaa uugaagagga uucggacgaa ccccuggagc gcaggcuuag ccucgugccg     2220

gauucagagc aaggggaggc cauucuuccc cggauuucgg ugauuucaac cggaccuaca     2280

cuucaggcga ggcgaaggca auccgugcuc aaccucauga cgcauucggu aaaccagggg     2340

caaaacauuc accgcaaaac gacggccuca acgagaaaag ugucacuugc accccaggcg     2400

aauuugacug aacucgacau cuacagccgu aggcuuucgc aagaaaccgg acuugagauc     2460

agcgaagaaa ucaaugaaga agauuugaaa gaguguuucu uugaugacau ggaaucaauc     2520

ccagcgguga caacguggaa cacauacuug cguuacauca cggugcacaa guccuugauu     2580

uucguccuca ucuggugucu cgugaucuuu cucgcugagg ucgcagcguc acuugugguc     2640

cucuggcugc uugguaauac gcccuugcaa gacaaaggca auucuacaca cucaagaaac     2700

aauuccuaug ccgugauuau cacuucuaca agcucguauu acguguuuua caucuacgua     2760

ggaguggccg acacucugcu cgcgaugggu uucuuccgag gacucccacu cguucacacg     2820

cuuaucacug ucuccaagau ucuccaccau aagaugcuuc auagcguacu gcaggcuccc     2880

auguccaccu ugaauacgcu caaggcggga gguauuuuga aucgcuucuc aaaagauauu     2940

gcaauuuugg augaccuucu gccccugacg aucuucgacu ucauccaguu guugcugauc     3000

gugauugggg cuauugcagu agucgcuguc cuccagccuu acauuuuugu cgcgaccguu     3060

ccggugaucg uggcguuuau caugcugcgg gccuauuucu ugcagacguc acagcagcuu     3120

aagcaacugg agucugaagg gaggucgccu aucuuuacgc aucuugugac caguuugaag     3180

ggauugugga cguugcgcgc cuuuggcagg cagcccuacu uugaaacacu guuccacaaa     3240

gcgcugaauc uccauacggc aaauugguuu uuguauuuga guacccuccg augguuucag     3300

augcgcauug agaugauuuu ugugaucuuc uuuaucgcgg ugacuuuuau cuccaucuug     3360

accacgggag agggcgaggg acgggucggu auuauccuga cacucgccau gaacauuaug     3420

agcacuuugc agugggcagu gaacagcucg auugaugugg auagccugau gagguccguu     3480

ucgagggucu uuaaguucau cgacaugccg acggagggaa agcccacaaa aaguacgaaa     3540

cccuauaaga augggcaauu gaguaaggua augaucaucg agaacaguca cgugaagaag     3600

gaugacaucu ggccuagcgg gggucagaug accgugaagg accugacggc aaaauacacc     3660

gagggaggga acgcaauccu ugaaaacauc ucguucagca uuagccccgg ucagcgugug     3720

ggguugcucg ggaggaccgg gucaggaaaa ucgacguugc ugucggccuu cuugagacuu     3780

cugaauacag agggugagau ccagaucgac ggcguuucgu gggauagcau caccuugcag     3840

caguggcgga aagcguuugg aguaaucccc caaaaggucu uuaucuuuag cggaaccuuc     3900

cgaaagaauc ucgauccuua ugaacagugg ucagaucaag agauuuggaa agucgcggac     3960

gagguuggcc uucggagugu aaucgagcag uuuccgggaa aacucgacuu uguccuugua     4020

gaugggggau gcguccuguc gcaugggcac aagcagcuca ugugccuggc gcgauccguc     4080

cucucuaaag cgaaaauucu ucucuuggau gaaccuucgg cccaucugga cccgguaacg     4140

uaucagauca ucagaaggac acuuaagcag gcguuugccg acugcacggu gauucucugu     4200

gagcaucgua ucgaggccau gcucgaaugc cagcaauuuc uugucaucga agagaauaag     4260

guccgccagu acgacuccau ccagaagcug cuuaaugaga gaucauuguu ccggcaggcg     4320

auuucaccau ccgauagggu gaaacuuuuu ccacacagaa auucgucgaa gugcaagucc     4380

aaaccgcaga ucgcggccuu gaaagaagag acugaagaag aaguucaaga cacgcgucuu     4440

uaa                                                                   4443


<210>  3
<211>  4443
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized oligonucleotide

<400>  3
augcagcggu ccuagcucga aaaggccagu gucgugucca aacucuucuu cucauggacu       60

cggccuaucc uuagaaaggg guaucggcag aggcuugagu ugucugacau cuaccaguga      120

cccucgguag auucggcgga uaaccucucg gagaagcucg aacgggaaug ggaccgcgaa      180

cucgcgucua agaaaaaccc gaagcucauc aacgcacuga gaaggugcuu cuucuggcgg      240

uucauguucu acgguaucuu cuuguaucuc ggggagguca caaaagcagu ccaaccccug      300

uuguuggguc gcauuaucgc cucguacgac cccgauaaca aagaagaacg gagcaucgcg      360

aucuaccucg ggaucggacu guguuugcuu uucaucguca gaacacuuuu guugcaucca      420

gcaaucuucg gccuccauca caucgguaug cagaugcgaa ucgcuauguu uagcuugauc      480

uacaaaaaga cacugaaacu cucgucgcgg guguuggaua agauuuccau cggucaguug      540

gugucccugc uuaguaauaa ccucaacaaa uucgaugagg gacuggcgcu ggcacauuuc      600

guguggauug ccccguugca agucgcccuu uugaugggcc uuauuuggga gcuguugcag      660

gcaucugccu uuuguggccu gggauuucug auuguguugg cauuguuuca ggcugggcuu      720

gggcggauga ugaugaagua ucgcgaccag agagcgggua aaaucucgga aagacucguc      780

aucacuucgg aaaugaucga aaacauccag ucggucaaag ccuauugcug ggaagaagcu      840

auggagaaga ugauugaaaa ccuccgccaa acugagcuga aacugacccg caaggcggcg      900

uauguccggu auuucaauuc gucagcguuc uucuuuuccg gguucuucgu ugucuuucuc      960

ucgguuuugc cuuaugccuu gauuaagggg auuauccucc gcaagauuuu caccacgauu     1020

ucguucugca uuguauugcg cauggcagug acacggcaau uuccgugggc cgugcagaca     1080

ugguaugacu cgcuuggagc gaucaacaaa auccaagacu ucuugcaaaa gcaagaguac     1140

aagacccugg aguacaaucu uacuacuacg gagguaguaa uggagaaugu gacggcuuuu     1200

ugggaagagg guuuuggaga acuguuugag aaagcaaagc agaauaacaa caaccgcaag     1260

accucaaaug gggacgauuc ccuguuuuuc ucgaacuucu cccugcucgg aacacccgug     1320

uugaaggaca ucaauuucaa gauugagagg ggacagcuuc ucgcgguagc gggaagcacu     1380

ggugcgggaa aaacuagccu cuugauggug auuauggggg agcuugagcc cagcgagggg     1440

aagauuaaac acuccgggcg uaucucauuc uguagccagu uuucauggau caugcccgga     1500

accauuaaag agaacaucau uuucggagua uccuaugaug aguaccgaua cagaucgguc     1560

auuaaggcgu gccaguugga agaggacauu ucuaaguucg ccgagaagga uaacaucguc     1620

uugggagaag gggguauuac auugucggga gggcagcgag cgcggaucag ccucgcgaga     1680

gcgguauaca aagaugcaga uuuguaucug cuugauucac cguuuggaua ccucgacgua     1740

uugacagaaa aagaaaucuu cgagucgugc guguguaaac uuauggcuaa uaagacgaga     1800

auccugguga caucaaaaau ggaacaccuu aagaaggcgg acaagauccu gauccuccac     1860

gaaggaucgu ccuacuuuua cggcacuuuc ucagaguugc aaaacuugca gccggacuuc     1920

ucaagcaaac ucauggggug ugacucauuc gaccaguuca gcgcggaacg gcggaacucg     1980

aucuugacgg aaacgcugca ccgauucucg cuugagggug augccccggu aucguggacc     2040

gagacaaaga agcagucguu uaagcagaca ggagaauuug gugagaaaag aaagaacagu     2100

aucuugaauc cuauuaacuc aauucgcaag uucucaaucg uccagaaaac uccacugcag     2160

augaauggaa uugaagagga uucggacgaa ccccuggagc gcaggcuuag ccucgugccg     2220

gauucagagc aaggggaggc cauucuuccc cggauuucgg ugauuucaac cggaccuaca     2280

cuucaggcga ggcgaaggca auccgugcuc aaccucauga cgcauucggu aaaccagggg     2340

caaaacauuc accgcaaaac gacggccuca acgagaaaag ugucacuugc accccaggcg     2400

aauuugacug aacucgacau cuacagccgu aggcuuucgc aagaaaccgg acuugagauc     2460

agcgaagaaa ucaaugaaga agauuugaaa gaguguuucu uugaugacau ggaaucaauc     2520

ccagcgguga caacguggaa cacauacuug cguuacauca cggugcacaa guccuugauu     2580

uucguccuca ucuggugucu cgugaucuuu cucgcugagg ucgcagcguc acuugugguc     2640

cucuggcugc uugguaauac gcccuugcaa gacaaaggca auucuacaca cucaagaaac     2700

aauuccuaug ccgugauuau cacuucuaca agcucguauu acguguuuua caucuacgua     2760

ggaguggccg acacucugcu cgcgaugggu uucuuccgag gacucccacu cguucacacg     2820

cuuaucacug ucuccaagau ucuccaccau aagaugcuuc auagcguacu gcaggcuccc     2880

auguccaccu ugaauacgcu caaggcggga gguauuuuga aucgcuucuc aaaagauauu     2940

gcaauuuugg augaccuucu gccccugacg aucuucgacu ucauccaguu guugcugauc     3000

gugauugggg cuauugcagu agucgcuguc cuccagccuu acauuuuugu cgcgaccguu     3060

ccggugaucg uggcguuuau caugcugcgg gccuauuucu ugcagacguc acagcagcuu     3120

aagcaacugg agucugaagg gaggucgccu aucuuuacgc aucuugugac caguuugaag     3180

ggauugugga cguugcgcgc cuuuggcagg cagcccuacu uugaaacacu guuccacaaa     3240

gcgcugaauc uccauacggc aaauugguuu uuguauuuga guacccuccg augguuucag     3300

augcgcauug agaugauuuu ugugaucuuc uuuaucgcgg ugacuuuuau cuccaucuug     3360

accacgggag agggcgaggg acgggucggu auuauccuga cacucgccau gaacauuaug     3420

agcacuuugc agugggcagu gaacagcucg auugaugugg auagccugau gagguccguu     3480

ucgagggucu uuaaguucau cgacaugccg acggagggaa agcccacaaa aaguacgaaa     3540

cccuauaaga augggcaauu gaguaaggua augaucaucg agaacaguca cgugaagaag     3600

gaugacaucu ggccuagcgg gggucagaug accgugaagg accugacggc aaaauacacc     3660

gagggaggga acgcaauccu ugaaaacauc ucguucagca uuagccccgg ucagcgugug     3720

ggguugcucg ggaggaccgg gucaggaaaa ucgacguugc ugucggccuu cuugagacuu     3780

cugaauacag agggugagau ccagaucgac ggcguuucgu gggauagcau caccuugcag     3840

caguggcgga aagcguuugg aguaaucccc caaaaggucu uuaucuuuag cggaaccuuc     3900

cgaaagaauc ucgauccuua ugaacagugg ucagaucaag agauuuggaa agucgcggac     3960

gagguuggcc uucggagugu aaucgagcag uuuccgggaa aacucgacuu uguccuugua     4020

gaugggggau gcguccuguc gcaugggcac aagcagcuca ugugccuggc gcgauccguc     4080

cucucuaaag cgaaaauucu ucucuuggau gaaccuucgg cccaucugga cccgguaacg     4140

uaucagauca ucagaaggac acuuaagcag gcguuugccg acugcacggu gauucucugu     4200

gagcaucgua ucgaggccau gcucgaaugc cagcaauuuc uugucaucga agagaauaag     4260

guccgccagu acgacuccau ccagaagcug cuuaaugaga gaucauuguu ccggcaggcg     4320

auuucaccau ccgauagggu gaaacuuuuu ccacacagaa auucgucgaa gugcaagucc     4380

aaaccgcaga ucgcggccuu gaaagaagag acugaagaag aaguucaaga cacgcgucuu     4440

uaa                                                                   4443


<210>  4
<211>  1480
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gln Arg Ser Pro Leu Glu Lys Ala Ser Val Val Ser Lys Leu Phe 
1               5                   10                  15      


Phe Ser Trp Thr Arg Pro Ile Leu Arg Lys Gly Tyr Arg Gln Arg Leu 
            20                  25                  30          


Glu Leu Ser Asp Ile Tyr Gln Ile Pro Ser Val Asp Ser Ala Asp Asn 
        35                  40                  45              


Leu Ser Glu Lys Leu Glu Arg Glu Trp Asp Arg Glu Leu Ala Ser Lys 
    50                  55                  60                  


Lys Asn Pro Lys Leu Ile Asn Ala Leu Arg Arg Cys Phe Phe Trp Arg 
65                  70                  75                  80  


Phe Met Phe Tyr Gly Ile Phe Leu Tyr Leu Gly Glu Val Thr Lys Ala 
                85                  90                  95      


Val Gln Pro Leu Leu Leu Gly Arg Ile Ile Ala Ser Tyr Asp Pro Asp 
            100                 105                 110         


Asn Lys Glu Glu Arg Ser Ile Ala Ile Tyr Leu Gly Ile Gly Leu Cys 
        115                 120                 125             


Leu Leu Phe Ile Val Arg Thr Leu Leu Leu His Pro Ala Ile Phe Gly 
    130                 135                 140                 


Leu His His Ile Gly Met Gln Met Arg Ile Ala Met Phe Ser Leu Ile 
145                 150                 155                 160 


Tyr Lys Lys Thr Leu Lys Leu Ser Ser Arg Val Leu Asp Lys Ile Ser 
                165                 170                 175     


Ile Gly Gln Leu Val Ser Leu Leu Ser Asn Asn Leu Asn Lys Phe Asp 
            180                 185                 190         


Glu Gly Leu Ala Leu Ala His Phe Val Trp Ile Ala Pro Leu Gln Val 
        195                 200                 205             


Ala Leu Leu Met Gly Leu Ile Trp Glu Leu Leu Gln Ala Ser Ala Phe 
    210                 215                 220                 


Cys Gly Leu Gly Phe Leu Ile Val Leu Ala Leu Phe Gln Ala Gly Leu 
225                 230                 235                 240 


Gly Arg Met Met Met Lys Tyr Arg Asp Gln Arg Ala Gly Lys Ile Ser 
                245                 250                 255     


Glu Arg Leu Val Ile Thr Ser Glu Met Ile Glu Asn Ile Gln Ser Val 
            260                 265                 270         


Lys Ala Tyr Cys Trp Glu Glu Ala Met Glu Lys Met Ile Glu Asn Leu 
        275                 280                 285             


Arg Gln Thr Glu Leu Lys Leu Thr Arg Lys Ala Ala Tyr Val Arg Tyr 
    290                 295                 300                 


Phe Asn Ser Ser Ala Phe Phe Phe Ser Gly Phe Phe Val Val Phe Leu 
305                 310                 315                 320 


Ser Val Leu Pro Tyr Ala Leu Ile Lys Gly Ile Ile Leu Arg Lys Ile 
                325                 330                 335     


Phe Thr Thr Ile Ser Phe Cys Ile Val Leu Arg Met Ala Val Thr Arg 
            340                 345                 350         


Gln Phe Pro Trp Ala Val Gln Thr Trp Tyr Asp Ser Leu Gly Ala Ile 
        355                 360                 365             


Asn Lys Ile Gln Asp Phe Leu Gln Lys Gln Glu Tyr Lys Thr Leu Glu 
    370                 375                 380                 


Tyr Asn Leu Thr Thr Thr Glu Val Val Met Glu Asn Val Thr Ala Phe 
385                 390                 395                 400 


Trp Glu Glu Gly Phe Gly Glu Leu Phe Glu Lys Ala Lys Gln Asn Asn 
                405                 410                 415     


Asn Asn Arg Lys Thr Ser Asn Gly Asp Asp Ser Leu Phe Phe Ser Asn 
            420                 425                 430         


Phe Ser Leu Leu Gly Thr Pro Val Leu Lys Asp Ile Asn Phe Lys Ile 
        435                 440                 445             


Glu Arg Gly Gln Leu Leu Ala Val Ala Gly Ser Thr Gly Ala Gly Lys 
    450                 455                 460                 


Thr Ser Leu Leu Met Val Ile Met Gly Glu Leu Glu Pro Ser Glu Gly 
465                 470                 475                 480 


Lys Ile Lys His Ser Gly Arg Ile Ser Phe Cys Ser Gln Phe Ser Trp 
                485                 490                 495     


Ile Met Pro Gly Thr Ile Lys Glu Asn Ile Ile Phe Gly Val Ser Tyr 
            500                 505                 510         


Asp Glu Tyr Arg Tyr Arg Ser Val Ile Lys Ala Cys Gln Leu Glu Glu 
        515                 520                 525             


Asp Ile Ser Lys Phe Ala Glu Lys Asp Asn Ile Val Leu Gly Glu Gly 
    530                 535                 540                 


Gly Ile Thr Leu Ser Gly Gly Gln Arg Ala Arg Ile Ser Leu Ala Arg 
545                 550                 555                 560 


Ala Val Tyr Lys Asp Ala Asp Leu Tyr Leu Leu Asp Ser Pro Phe Gly 
                565                 570                 575     


Tyr Leu Asp Val Leu Thr Glu Lys Glu Ile Phe Glu Ser Cys Val Cys 
            580                 585                 590         


Lys Leu Met Ala Asn Lys Thr Arg Ile Leu Val Thr Ser Lys Met Glu 
        595                 600                 605             


His Leu Lys Lys Ala Asp Lys Ile Leu Ile Leu His Glu Gly Ser Ser 
    610                 615                 620                 


Tyr Phe Tyr Gly Thr Phe Ser Glu Leu Gln Asn Leu Gln Pro Asp Phe 
625                 630                 635                 640 


Ser Ser Lys Leu Met Gly Cys Asp Ser Phe Asp Gln Phe Ser Ala Glu 
                645                 650                 655     


Arg Arg Asn Ser Ile Leu Thr Glu Thr Leu His Arg Phe Ser Leu Glu 
            660                 665                 670         


Gly Asp Ala Pro Val Ser Trp Thr Glu Thr Lys Lys Gln Ser Phe Lys 
        675                 680                 685             


Gln Thr Gly Glu Phe Gly Glu Lys Arg Lys Asn Ser Ile Leu Asn Pro 
    690                 695                 700                 


Ile Asn Ser Ile Arg Lys Phe Ser Ile Val Gln Lys Thr Pro Leu Gln 
705                 710                 715                 720 


Met Asn Gly Ile Glu Glu Asp Ser Asp Glu Pro Leu Glu Arg Arg Leu 
                725                 730                 735     


Ser Leu Val Pro Asp Ser Glu Gln Gly Glu Ala Ile Leu Pro Arg Ile 
            740                 745                 750         


Ser Val Ile Ser Thr Gly Pro Thr Leu Gln Ala Arg Arg Arg Gln Ser 
        755                 760                 765             


Val Leu Asn Leu Met Thr His Ser Val Asn Gln Gly Gln Asn Ile His 
    770                 775                 780                 


Arg Lys Thr Thr Ala Ser Thr Arg Lys Val Ser Leu Ala Pro Gln Ala 
785                 790                 795                 800 


Asn Leu Thr Glu Leu Asp Ile Tyr Ser Arg Arg Leu Ser Gln Glu Thr 
                805                 810                 815     


Gly Leu Glu Ile Ser Glu Glu Ile Asn Glu Glu Asp Leu Lys Glu Cys 
            820                 825                 830         


Phe Phe Asp Asp Met Glu Ser Ile Pro Ala Val Thr Thr Trp Asn Thr 
        835                 840                 845             


Tyr Leu Arg Tyr Ile Thr Val His Lys Ser Leu Ile Phe Val Leu Ile 
    850                 855                 860                 


Trp Cys Leu Val Ile Phe Leu Ala Glu Val Ala Ala Ser Leu Val Val 
865                 870                 875                 880 


Leu Trp Leu Leu Gly Asn Thr Pro Leu Gln Asp Lys Gly Asn Ser Thr 
                885                 890                 895     


His Ser Arg Asn Asn Ser Tyr Ala Val Ile Ile Thr Ser Thr Ser Ser 
            900                 905                 910         


Tyr Tyr Val Phe Tyr Ile Tyr Val Gly Val Ala Asp Thr Leu Leu Ala 
        915                 920                 925             


Met Gly Phe Phe Arg Gly Leu Pro Leu Val His Thr Leu Ile Thr Val 
    930                 935                 940                 


Ser Lys Ile Leu His His Lys Met Leu His Ser Val Leu Gln Ala Pro 
945                 950                 955                 960 


Met Ser Thr Leu Asn Thr Leu Lys Ala Gly Gly Ile Leu Asn Arg Phe 
                965                 970                 975     


Ser Lys Asp Ile Ala Ile Leu Asp Asp Leu Leu Pro Leu Thr Ile Phe 
            980                 985                 990         


Asp Phe Ile Gln Leu Leu Leu Ile  Val Ile Gly Ala Ile  Ala Val Val 
        995                 1000                 1005             


Ala Val  Leu Gln Pro Tyr Ile  Phe Val Ala Thr Val  Pro Val Ile 
    1010                 1015                 1020             


Val Ala  Phe Ile Met Leu Arg  Ala Tyr Phe Leu Gln  Thr Ser Gln 
    1025                 1030                 1035             


Gln Leu  Lys Gln Leu Glu Ser  Glu Gly Arg Ser Pro  Ile Phe Thr 
    1040                 1045                 1050             


His Leu  Val Thr Ser Leu Lys  Gly Leu Trp Thr Leu  Arg Ala Phe 
    1055                 1060                 1065             


Gly Arg  Gln Pro Tyr Phe Glu  Thr Leu Phe His Lys  Ala Leu Asn 
    1070                 1075                 1080             


Leu His  Thr Ala Asn Trp Phe  Leu Tyr Leu Ser Thr  Leu Arg Trp 
    1085                 1090                 1095             


Phe Gln  Met Arg Ile Glu Met  Ile Phe Val Ile Phe  Phe Ile Ala 
    1100                 1105                 1110             


Val Thr  Phe Ile Ser Ile Leu  Thr Thr Gly Glu Gly  Glu Gly Arg 
    1115                 1120                 1125             


Val Gly  Ile Ile Leu Thr Leu  Ala Met Asn Ile Met  Ser Thr Leu 
    1130                 1135                 1140             


Gln Trp  Ala Val Asn Ser Ser  Ile Asp Val Asp Ser  Leu Met Arg 
    1145                 1150                 1155             


Ser Val  Ser Arg Val Phe Lys  Phe Ile Asp Met Pro  Thr Glu Gly 
    1160                 1165                 1170             


Lys Pro  Thr Lys Ser Thr Lys  Pro Tyr Lys Asn Gly  Gln Leu Ser 
    1175                 1180                 1185             


Lys Val  Met Ile Ile Glu Asn  Ser His Val Lys Lys  Asp Asp Ile 
    1190                 1195                 1200             


Trp Pro  Ser Gly Gly Gln Met  Thr Val Lys Asp Leu  Thr Ala Lys 
    1205                 1210                 1215             


Tyr Thr  Glu Gly Gly Asn Ala  Ile Leu Glu Asn Ile  Ser Phe Ser 
    1220                 1225                 1230             


Ile Ser  Pro Gly Gln Arg Val  Gly Leu Leu Gly Arg  Thr Gly Ser 
    1235                 1240                 1245             


Gly Lys  Ser Thr Leu Leu Ser  Ala Phe Leu Arg Leu  Leu Asn Thr 
    1250                 1255                 1260             


Glu Gly  Glu Ile Gln Ile Asp  Gly Val Ser Trp Asp  Ser Ile Thr 
    1265                 1270                 1275             


Leu Gln  Gln Trp Arg Lys Ala  Phe Gly Val Ile Pro  Gln Lys Val 
    1280                 1285                 1290             


Phe Ile  Phe Ser Gly Thr Phe  Arg Lys Asn Leu Asp  Pro Tyr Glu 
    1295                 1300                 1305             


Gln Trp  Ser Asp Gln Glu Ile  Trp Lys Val Ala Asp  Glu Val Gly 
    1310                 1315                 1320             


Leu Arg  Ser Val Ile Glu Gln  Phe Pro Gly Lys Leu  Asp Phe Val 
    1325                 1330                 1335             


Leu Val  Asp Gly Gly Cys Val  Leu Ser His Gly His  Lys Gln Leu 
    1340                 1345                 1350             


Met Cys  Leu Ala Arg Ser Val  Leu Ser Lys Ala Lys  Ile Leu Leu 
    1355                 1360                 1365             


Leu Asp  Glu Pro Ser Ala His  Leu Asp Pro Val Thr  Tyr Gln Ile 
    1370                 1375                 1380             


Ile Arg  Arg Thr Leu Lys Gln  Ala Phe Ala Asp Cys  Thr Val Ile 
    1385                 1390                 1395             


Leu Cys  Glu His Arg Ile Glu  Ala Met Leu Glu Cys  Gln Gln Phe 
    1400                 1405                 1410             


Leu Val  Ile Glu Glu Asn Lys  Val Arg Gln Tyr Asp  Ser Ile Gln 
    1415                 1420                 1425             


Lys Leu  Leu Asn Glu Arg Ser  Leu Phe Arg Gln Ala  Ile Ser Pro 
    1430                 1435                 1440             


Ser Asp  Arg Val Lys Leu Phe  Pro His Arg Asn Ser  Ser Lys Cys 
    1445                 1450                 1455             


Lys Ser  Lys Pro Gln Ile Ala  Ala Leu Lys Glu Glu  Thr Glu Glu 
    1460                 1465                 1470             


Glu Val  Gln Asp Thr Arg Leu  
    1475                 1480 


<210>  5
<211>  140
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized oligonucleotide

<400>  5
ggacagaucg ccuggagacg ccauccacgc uguuuugacc uccauagaag acaccgggac       60

cgauccagcc uccgcggccg ggaacggugc auuggaacgc ggauuccccg ugccaagagu      120

gacucaccgu ccuugacacg                                                  140


<210>  6
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized oligonucleotide

<400>  6
cggguggcau cccugugacc ccuccccagu gccucuccug gcccuggaag uugccacucc       60

agugcccacc agccuugucc uaauaaaauu aaguugcauc aagcu                      105


<210>  7
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized oligonucleotide

<400>  7
ggguggcauc ccugugaccc cuccccagug ccucuccugg cccuggaagu ugccacucca       60

gugcccacca gccuuguccu aauaaaauua aguugcauca aagcu                      105


<210>  8
<211>  4688
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized oligonucleotide

<400>  8
ggacagaucg ccuggagacg ccauccacgc uguuuugacc uccauagaag acaccgggac       60

cgauccagcc uccgcggccg ggaacggugc auuggaacgc ggauuccccg ugccaagagu      120

gacucaccgu ccuugacacg augcaacgcu cuccucuuga aaaggccucg guggugucca      180

agcucuucuu cucguggacu agacccaucc ugagaaaggg guacagacag cgcuuggagc      240

uguccgauau cuaucaaauc ccuuccgugg acuccgcgga caaccugucc gagaagcucg      300

agagagaaug ggacagagaa cucgccucaa agaagaaccc gaagcugauu aaugcgcuua      360

ggcggugcuu uuucuggcgg uucauguucu acggcaucuu ccucuaccug ggagagguca      420

ccaaggccgu gcagccccug uugcugggac ggauuauugc cuccuacgac cccgacaaca      480

aggaagaaag aagcaucgcu aucuacuugg gcaucggucu gugccugcuu uucaucgucc      540

ggacccucuu guugcauccu gcuauuuucg gccugcauca cauuggcaug cagaugagaa      600

uugccauguu uucccugauc uacaagaaaa cucugaagcu cucgagccgc gugcuugaca      660

agauuuccau cggccagcuc gugucccugc ucuccaacaa ucugaacaag uucgacgagg      720

gccucgcccu ggcccacuuc guguggaucg ccccucugca aguggcgcuu cugaugggcc      780

ugaucuggga gcugcugcaa gccucggcau ucugugggcu uggauuccug aucgugcugg      840

cacuguucca ggccggacug gggcggauga ugaugaagua cagggaccag agagccggaa      900

agauuuccga acggcuggug aucacuucgg aaaugaucga aaacauccag ucagugaagg      960

ccuacugcug ggaagaggcc auggaaaaga ugauugaaaa ccuccggcaa accgagcuga     1020

agcugacccg caaggccgcu uacgugcgcu auuucaacuc guccgcuuuc uucuucuccg     1080

gguucuucgu gguguuucuc uccgugcucc ccuacgcccu gauuaaggga aucauccuca     1140

ggaagaucuu caccaccauu uccuucugua ucgugcuccg cauggccgug acccggcagu     1200

ucccaugggc cgugcagacu ugguacgacu cccugggagc cauuaacaag auccaggacu     1260

uccuucaaaa gcaggaguac aagacccucg aguacaaccu gacuacuacc gaggucguga     1320

uggaaaacgu caccgccuuu ugggaggagg gauuuggcga acuguucgag aaggccaagc     1380

agaacaacaa caaccgcaag accucgaacg gugacgacuc ccucuucuuu ucaaacuuca     1440

gccugcucgg gacgcccgug cugaaggaca uuaacuucaa gaucgaaaga ggacagcucc     1500

uggcgguggc cggaucgacc ggagccggaa agacuucccu gcugauggug aucaugggag     1560

agcuugaacc uagcgaggga aagaucaagc acuccggccg caucagcuuc uguagccagu     1620

uuuccuggau caugcccgga accauuaagg aaaacaucau cuucggcgug uccuacgaug     1680

aauaccgcua ccgguccgug aucaaagccu gccagcugga agaggauauu ucaaaguucg     1740

cggagaaaga uaacaucgug cugggcgaag gggguauuac cuugucgggg ggccagcggg     1800

cuagaaucuc gcuggccaga gccguguaua aggacgccga ccuguaucuc cuggacuccc     1860

ccuucggaua ccuggacguc cugaccgaaa aggagaucuu cgaaucgugc gugugcaagc     1920

ugauggcuaa caagacucgc auccucguga ccuccaaaau ggagcaccug aagaaggcag     1980

acaagauucu gauucugcau gagggguccu ccuacuuuua cggcaccuuc ucggaguugc     2040

agaacuugca gcccgacuuc ucaucgaagc ugauggguug cgacagcuuc gaccaguucu     2100

ccgccgaaag aaggaacucg auccugacgg aaaccuugca ccgcuucucu uuggaaggcg     2160

acgccccugu gucauggacc gagacuaaga agcagagcuu caagcagacc ggggaauucg     2220

gcgaaaagag gaagaacagc aucuugaacc ccauuaacuc cauccgcaag uucucaaucg     2280

ugcaaaagac gccacugcag augaacggca uugaggagga cuccgacgaa ccccuugaga     2340

ggcgccuguc ccuggugccg gacagcgagc agggagaagc cauccugccu cggauuuccg     2400

ugaucuccac ugguccgacg cuccaagccc ggcggcggca guccgugcug aaccugauga     2460

cccacagcgu gaaccagggc caaaacauuc accgcaagac uaccgcaucc acccggaaag     2520

ugucccuggc accucaagcg aaucuuaccg agcucgacau cuacucccgg agacugucgc     2580

aggaaaccgg gcucgaaauu uccgaagaaa ucaacgagga ggaucugaaa gagugcuucu     2640

ucgacgauau ggagucgaua cccgccguga cgacuuggaa cacuuaucug cgguacauca     2700

cugugcacaa gucauugauc uucgugcuga uuuggugccu ggugauuuuc cuggccgagg     2760

ucgcggccuc acugguggug cucuggcugu ugggaaacac gccucugcaa gacaagggaa     2820

acuccacgca cucgagaaac aacagcuaug ccgugauuau cacuuccacc uccucuuauu     2880

acguguucua caucuacguc ggaguggcgg auacccugcu cgcgaugggu uucuucagag     2940

gacugccgcu gguccacacc uugaucaccg ucagcaagau ucuucaccac aagauguugc     3000

auagcgugcu gcaggccccc auguccaccc ucaacacucu gaaggccgga ggcauucuga     3060

acagauucuc caaggacauc gcuauccugg acgaucuccu gccgcuuacc aucuuugacu     3120

ucauccagcu gcugcugauc gugauuggag caaucgcagu gguggcggug cugcagccuu     3180

acauuuucgu ggccacugug ccggucauug uggcguucau caugcugcgg gccuacuucc     3240

uccaaaccag ccagcagcug aagcaacugg aauccgaggg acgauccccc aucuucacuc     3300

accuugugac gucguugaag ggacugugga cccuccgggc uuucggacgg cagcccuacu     3360

ucgaaacccu cuuccacaag gcccugaacc uccacaccgc caauugguuc cuguaccugu     3420

ccacccugcg gugguuccag augcgcaucg agaugauuuu cgucaucuuc uucaucgcgg     3480

ucacauucau cagcauccug acuaccggag agggagaggg acgggucgga auaauccuga     3540

cccucgccau gaacauuaug agcacccugc agugggcagu gaacagcucg aucgacgugg     3600

acagccugau gcgaagcguc agccgcgugu ucaaguucau cgacaugccu acugagggaa     3660

aacccacuaa guccacuaag cccuacaaaa auggccagcu gagcaagguc augaucaucg     3720

aaaacuccca cgugaagaag gacgauauuu ggcccuccgg aggucaaaug accgugaagg     3780

accugaccgc aaaguacacc gagggaggaa acgccauucu cgaaaacauc agcuucucca     3840

uuucgccggg acagcggguc ggccuucucg ggcggaccgg uuccgggaag ucaacucugc     3900

ugucggcuuu ccuccggcug cugaauaccg agggggaaau ccaaauugac ggcgugucuu     3960

gggauuccau uacucugcag caguggcgga aggccuucgg cgugaucccc cagaaggugu     4020

ucaucuucuc ggguaccuuc cggaagaacc uggauccuua cgagcagugg agcgaccaag     4080

aaaucuggaa ggucgccgac gaggucggcc ugcgcuccgu gauugaacaa uuuccuggaa     4140

agcuggacuu cgugcucguc gacgggggau guguccuguc gcacggacau aagcagcuca     4200

ugugccucgc acgguccgug cucuccaagg ccaagauucu gcugcuggac gaaccuucgg     4260

cccaccugga uccggucacc uaccagauca ucaggaggac ccugaagcag gccuuugccg     4320

auugcaccgu gauucucugc gagcaccgca ucgaggccau gcuggagugc cagcaguucc     4380

uggucaucga ggagaacaag guccgccaau acgacuccau ucaaaagcuc cucaacgagc     4440

ggucgcuguu cagacaagcu auuucaccgu ccgauagagu gaagcucuuc ccgcaucgga     4500

acagcucaaa gugcaaaucg aagccgcaga ucgcagccuu gaaggaagag acugaggaag     4560

aggugcagga cacccggcuu uaacgggugg caucccugug accccucccc agugccucuc     4620

cuggcccugg aaguugccac uccagugccc accagccuug uccuaauaaa auuaaguugc     4680

aucaagcu                                                              4688


<210>  9
<211>  4688
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized oligonucleotide

<400>  9
ggacagaucg ccuggagacg ccauccacgc uguuuugacc uccauagaag acaccgggac       60

cgauccagcc uccgcggccg ggaacggugc auuggaacgc ggauuccccg ugccaagagu      120

gacucaccgu ccuugacacg augcaacgcu cuccucuuga aaaggccucg guggugucca      180

agcucuucuu cucguggacu agacccaucc ugagaaaggg guacagacag cgcuuggagc      240

uguccgauau cuaucaaauc ccuuccgugg acuccgcgga caaccugucc gagaagcucg      300

agagagaaug ggacagagaa cucgccucaa agaagaaccc gaagcugauu aaugcgcuua      360

ggcggugcuu uuucuggcgg uucauguucu acggcaucuu ccucuaccug ggagagguca      420

ccaaggccgu gcagccccug uugcugggac ggauuauugc cuccuacgac cccgacaaca      480

aggaagaaag aagcaucgcu aucuacuugg gcaucggucu gugccugcuu uucaucgucc      540

ggacccucuu guugcauccu gcuauuuucg gccugcauca cauuggcaug cagaugagaa      600

uugccauguu uucccugauc uacaagaaaa cucugaagcu cucgagccgc gugcuugaca      660

agauuuccau cggccagcuc gugucccugc ucuccaacaa ucugaacaag uucgacgagg      720

gccucgcccu ggcccacuuc guguggaucg ccccucugca aguggcgcuu cugaugggcc      780

ugaucuggga gcugcugcaa gccucggcau ucugugggcu uggauuccug aucgugcugg      840

cacuguucca ggccggacug gggcggauga ugaugaagua cagggaccag agagccggaa      900

agauuuccga acggcuggug aucacuucgg aaaugaucga aaacauccag ucagugaagg      960

ccuacugcug ggaagaggcc auggaaaaga ugauugaaaa ccuccggcaa accgagcuga     1020

agcugacccg caaggccgcu uacgugcgcu auuucaacuc guccgcuuuc uucuucuccg     1080

gguucuucgu gguguuucuc uccgugcucc ccuacgcccu gauuaaggga aucauccuca     1140

ggaagaucuu caccaccauu uccuucugua ucgugcuccg cauggccgug acccggcagu     1200

ucccaugggc cgugcagacu ugguacgacu cccugggagc cauuaacaag auccaggacu     1260

uccuucaaaa gcaggaguac aagacccucg aguacaaccu gacuacuacc gaggucguga     1320

uggaaaacgu caccgccuuu ugggaggagg gauuuggcga acuguucgag aaggccaagc     1380

agaacaacaa caaccgcaag accucgaacg gugacgacuc ccucuucuuu ucaaacuuca     1440

gccugcucgg gacgcccgug cugaaggaca uuaacuucaa gaucgaaaga ggacagcucc     1500

uggcgguggc cggaucgacc ggagccggaa agacuucccu gcugauggug aucaugggag     1560

agcuugaacc uagcgaggga aagaucaagc acuccggccg caucagcuuc uguagccagu     1620

uuuccuggau caugcccgga accauuaagg aaaacaucau cuucggcgug uccuacgaug     1680

aauaccgcua ccgguccgug aucaaagccu gccagcugga agaggauauu ucaaaguucg     1740

cggagaaaga uaacaucgug cugggcgaag gggguauuac cuugucgggg ggccagcggg     1800

cuagaaucuc gcuggccaga gccguguaua aggacgccga ccuguaucuc cuggacuccc     1860

ccuucggaua ccuggacguc cugaccgaaa aggagaucuu cgaaucgugc gugugcaagc     1920

ugauggcuaa caagacucgc auccucguga ccuccaaaau ggagcaccug aagaaggcag     1980

acaagauucu gauucugcau gagggguccu ccuacuuuua cggcaccuuc ucggaguugc     2040

agaacuugca gcccgacuuc ucaucgaagc ugauggguug cgacagcuuc gaccaguucu     2100

ccgccgaaag aaggaacucg auccugacgg aaaccuugca ccgcuucucu uuggaaggcg     2160

acgccccugu gucauggacc gagacuaaga agcagagcuu caagcagacc ggggaauucg     2220

gcgaaaagag gaagaacagc aucuugaacc ccauuaacuc cauccgcaag uucucaaucg     2280

ugcaaaagac gccacugcag augaacggca uugaggagga cuccgacgaa ccccuugaga     2340

ggcgccuguc ccuggugccg gacagcgagc agggagaagc cauccugccu cggauuuccg     2400

ugaucuccac ugguccgacg cuccaagccc ggcggcggca guccgugcug aaccugauga     2460

cccacagcgu gaaccagggc caaaacauuc accgcaagac uaccgcaucc acccggaaag     2520

ugucccuggc accucaagcg aaucuuaccg agcucgacau cuacucccgg agacugucgc     2580

aggaaaccgg gcucgaaauu uccgaagaaa ucaacgagga ggaucugaaa gagugcuucu     2640

ucgacgauau ggagucgaua cccgccguga cgacuuggaa cacuuaucug cgguacauca     2700

cugugcacaa gucauugauc uucgugcuga uuuggugccu ggugauuuuc cuggccgagg     2760

ucgcggccuc acugguggug cucuggcugu ugggaaacac gccucugcaa gacaagggaa     2820

acuccacgca cucgagaaac aacagcuaug ccgugauuau cacuuccacc uccucuuauu     2880

acguguucua caucuacguc ggaguggcgg auacccugcu cgcgaugggu uucuucagag     2940

gacugccgcu gguccacacc uugaucaccg ucagcaagau ucuucaccac aagauguugc     3000

auagcgugcu gcaggccccc auguccaccc ucaacacucu gaaggccgga ggcauucuga     3060

acagauucuc caaggacauc gcuauccugg acgaucuccu gccgcuuacc aucuuugacu     3120

ucauccagcu gcugcugauc gugauuggag caaucgcagu gguggcggug cugcagccuu     3180

acauuuucgu ggccacugug ccggucauug uggcguucau caugcugcgg gccuacuucc     3240

uccaaaccag ccagcagcug aagcaacugg aauccgaggg acgauccccc aucuucacuc     3300

accuugugac gucguugaag ggacugugga cccuccgggc uuucggacgg cagcccuacu     3360

ucgaaacccu cuuccacaag gcccugaacc uccacaccgc caauugguuc cuguaccugu     3420

ccacccugcg gugguuccag augcgcaucg agaugauuuu cgucaucuuc uucaucgcgg     3480

ucacauucau cagcauccug acuaccggag agggagaggg acgggucgga auaauccuga     3540

cccucgccau gaacauuaug agcacccugc agugggcagu gaacagcucg aucgacgugg     3600

acagccugau gcgaagcguc agccgcgugu ucaaguucau cgacaugccu acugagggaa     3660

aacccacuaa guccacuaag cccuacaaaa auggccagcu gagcaagguc augaucaucg     3720

aaaacuccca cgugaagaag gacgauauuu ggcccuccgg aggucaaaug accgugaagg     3780

accugaccgc aaaguacacc gagggaggaa acgccauucu cgaaaacauc agcuucucca     3840

uuucgccggg acagcggguc ggccuucucg ggcggaccgg uuccgggaag ucaacucugc     3900

ugucggcuuu ccuccggcug cugaauaccg agggggaaau ccaaauugac ggcgugucuu     3960

gggauuccau uacucugcag caguggcgga aggccuucgg cgugaucccc cagaaggugu     4020

ucaucuucuc ggguaccuuc cggaagaacc uggauccuua cgagcagugg agcgaccaag     4080

aaaucuggaa ggucgccgac gaggucggcc ugcgcuccgu gauugaacaa uuuccuggaa     4140

agcuggacuu cgugcucguc gacgggggau guguccuguc gcacggacau aagcagcuca     4200

ugugccucgc acgguccgug cucuccaagg ccaagauucu gcugcuggac gaaccuucgg     4260

cccaccugga uccggucacc uaccagauca ucaggaggac ccugaagcag gccuuugccg     4320

auugcaccgu gauucucugc gagcaccgca ucgaggccau gcuggagugc cagcaguucc     4380

uggucaucga ggagaacaag guccgccaau acgacuccau ucaaaagcuc cucaacgagc     4440

ggucgcuguu cagacaagcu auuucaccgu ccgauagagu gaagcucuuc ccgcaucgga     4500

acagcucaaa gugcaaaucg aagccgcaga ucgcagccuu gaaggaagag acugaggaag     4560

aggugcagga cacccggcuu uaaggguggc aucccuguga ccccucccca gugccucucc     4620

uggcccugga aguugccacu ccagugccca ccagccuugu ccuaauaaaa uuaaguugca     4680

ucaaagcu                                                              4688


<210>  10
<211>  4688
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized oligonucleotide

<400>  10
ggacagaucg ccuggagacg ccauccacgc uguuuugacc uccauagaag acaccgggac       60

cgauccagcc uccgcggccg ggaacggugc auuggaacgc ggauuccccg ugccaagagu      120

gacucaccgu ccuugacacg augcagcggu ccccgcucga aaaggccagu gucgugucca      180

aacucuucuu cucauggacu cggccuaucc uuagaaaggg guaucggcag aggcuugagu      240

ugucugacau cuaccagauc cccucgguag auucggcgga uaaccucucg gagaagcucg      300

aacgggaaug ggaccgcgaa cucgcgucua agaaaaaccc gaagcucauc aacgcacuga      360

gaaggugcuu cuucuggcgg uucauguucu acgguaucuu cuuguaucuc ggggagguca      420

caaaagcagu ccaaccccug uuguuggguc gcauuaucgc cucguacgac cccgauaaca      480

aagaagaacg gagcaucgcg aucuaccucg ggaucggacu guguuugcuu uucaucguca      540

gaacacuuuu guugcaucca gcaaucuucg gccuccauca caucgguaug cagaugcgaa      600

ucgcuauguu uagcuugauc uacaaaaaga cacugaaacu cucgucgcgg guguuggaua      660

agauuuccau cggucaguug gugucccugc uuaguaauaa ccucaacaaa uucgaugagg      720

gacuggcgcu ggcacauuuc guguggauug ccccguugca agucgcccuu uugaugggcc      780

uuauuuggga gcuguugcag gcaucugccu uuuguggccu gggauuucug auuguguugg      840

cauuguuuca ggcugggcuu gggcggauga ugaugaagua ucgcgaccag agagcgggua      900

aaaucucgga aagacucguc aucacuucgg aaaugaucga aaacauccag ucggucaaag      960

ccuauugcug ggaagaagcu auggagaaga ugauugaaaa ccuccgccaa acugagcuga     1020

aacugacccg caaggcggcg uauguccggu auuucaauuc gucagcguuc uucuuuuccg     1080

gguucuucgu ugucuuucuc ucgguuuugc cuuaugccuu gauuaagggg auuauccucc     1140

gcaagauuuu caccacgauu ucguucugca uuguauugcg cauggcagug acacggcaau     1200

uuccgugggc cgugcagaca ugguaugacu cgcuuggagc gaucaacaaa auccaagacu     1260

ucuugcaaaa gcaagaguac aagacccugg aguacaaucu uacuacuacg gagguaguaa     1320

uggagaaugu gacggcuuuu ugggaagagg guuuuggaga acuguuugag aaagcaaagc     1380

agaauaacaa caaccgcaag accucaaaug gggacgauuc ccuguuuuuc ucgaacuucu     1440

cccugcucgg aacacccgug uugaaggaca ucaauuucaa gauugagagg ggacagcuuc     1500

ucgcgguagc gggaagcacu ggugcgggaa aaacuagccu cuugauggug auuauggggg     1560

agcuugagcc cagcgagggg aagauuaaac acuccgggcg uaucucauuc uguagccagu     1620

uuucauggau caugcccgga accauuaaag agaacaucau uuucggagua uccuaugaug     1680

aguaccgaua cagaucgguc auuaaggcgu gccaguugga agaggacauu ucuaaguucg     1740

ccgagaagga uaacaucguc uugggagaag gggguauuac auugucggga gggcagcgag     1800

cgcggaucag ccucgcgaga gcgguauaca aagaugcaga uuuguaucug cuugauucac     1860

cguuuggaua ccucgacgua uugacagaaa aagaaaucuu cgagucgugc guguguaaac     1920

uuauggcuaa uaagacgaga auccugguga caucaaaaau ggaacaccuu aagaaggcgg     1980

acaagauccu gauccuccac gaaggaucgu ccuacuuuua cggcacuuuc ucagaguugc     2040

aaaacuugca gccggacuuc ucaagcaaac ucauggggug ugacucauuc gaccaguuca     2100

gcgcggaacg gcggaacucg aucuugacgg aaacgcugca ccgauucucg cuugagggug     2160

augccccggu aucguggacc gagacaaaga agcagucguu uaagcagaca ggagaauuug     2220

gugagaaaag aaagaacagu aucuugaauc cuauuaacuc aauucgcaag uucucaaucg     2280

uccagaaaac uccacugcag augaauggaa uugaagagga uucggacgaa ccccuggagc     2340

gcaggcuuag ccucgugccg gauucagagc aaggggaggc cauucuuccc cggauuucgg     2400

ugauuucaac cggaccuaca cuucaggcga ggcgaaggca auccgugcuc aaccucauga     2460

cgcauucggu aaaccagggg caaaacauuc accgcaaaac gacggccuca acgagaaaag     2520

ugucacuugc accccaggcg aauuugacug aacucgacau cuacagccgu aggcuuucgc     2580

aagaaaccgg acuugagauc agcgaagaaa ucaaugaaga agauuugaaa gaguguuucu     2640

uugaugacau ggaaucaauc ccagcgguga caacguggaa cacauacuug cguuacauca     2700

cggugcacaa guccuugauu uucguccuca ucuggugucu cgugaucuuu cucgcugagg     2760

ucgcagcguc acuugugguc cucuggcugc uugguaauac gcccuugcaa gacaaaggca     2820

auucuacaca cucaagaaac aauuccuaug ccgugauuau cacuucuaca agcucguauu     2880

acguguuuua caucuacgua ggaguggccg acacucugcu cgcgaugggu uucuuccgag     2940

gacucccacu cguucacacg cuuaucacug ucuccaagau ucuccaccau aagaugcuuc     3000

auagcguacu gcaggcuccc auguccaccu ugaauacgcu caaggcggga gguauuuuga     3060

aucgcuucuc aaaagauauu gcaauuuugg augaccuucu gccccugacg aucuucgacu     3120

ucauccaguu guugcugauc gugauugggg cuauugcagu agucgcuguc cuccagccuu     3180

acauuuuugu cgcgaccguu ccggugaucg uggcguuuau caugcugcgg gccuauuucu     3240

ugcagacguc acagcagcuu aagcaacugg agucugaagg gaggucgccu aucuuuacgc     3300

aucuugugac caguuugaag ggauugugga cguugcgcgc cuuuggcagg cagcccuacu     3360

uugaaacacu guuccacaaa gcgcugaauc uccauacggc aaauugguuu uuguauuuga     3420

guacccuccg augguuucag augcgcauug agaugauuuu ugugaucuuc uuuaucgcgg     3480

ugacuuuuau cuccaucuug accacgggag agggcgaggg acgggucggu auuauccuga     3540

cacucgccau gaacauuaug agcacuuugc agugggcagu gaacagcucg auugaugugg     3600

auagccugau gagguccguu ucgagggucu uuaaguucau cgacaugccg acggagggaa     3660

agcccacaaa aaguacgaaa cccuauaaga augggcaauu gaguaaggua augaucaucg     3720

agaacaguca cgugaagaag gaugacaucu ggccuagcgg gggucagaug accgugaagg     3780

accugacggc aaaauacacc gagggaggga acgcaauccu ugaaaacauc ucguucagca     3840

uuagccccgg ucagcgugug ggguugcucg ggaggaccgg gucaggaaaa ucgacguugc     3900

ugucggccuu cuugagacuu cugaauacag agggugagau ccagaucgac ggcguuucgu     3960

gggauagcau caccuugcag caguggcgga aagcguuugg aguaaucccc caaaaggucu     4020

uuaucuuuag cggaaccuuc cgaaagaauc ucgauccuua ugaacagugg ucagaucaag     4080

agauuuggaa agucgcggac gagguuggcc uucggagugu aaucgagcag uuuccgggaa     4140

aacucgacuu uguccuugua gaugggggau gcguccuguc gcaugggcac aagcagcuca     4200

ugugccuggc gcgauccguc cucucuaaag cgaaaauucu ucucuuggau gaaccuucgg     4260

cccaucugga cccgguaacg uaucagauca ucagaaggac acuuaagcag gcguuugccg     4320

acugcacggu gauucucugu gagcaucgua ucgaggccau gcucgaaugc cagcaauuuc     4380

uugucaucga agagaauaag guccgccagu acgacuccau ccagaagcug cuuaaugaga     4440

gaucauuguu ccggcaggcg auuucaccau ccgauagggu gaaacuuuuu ccacacagaa     4500

auucgucgaa gugcaagucc aaaccgcaga ucgcggccuu gaaagaagag acugaagaag     4560

aaguucaaga cacgcgucuu uaacgggugg caucccugug accccucccc agugccucuc     4620

cuggcccugg aaguugccac uccagugccc accagccuug uccuaauaaa auuaaguugc     4680

aucaagcu                                                              4688


<210>  11
<211>  4688
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized oligonucleotide

<400>  11
ggacagaucg ccuggagacg ccauccacgc uguuuugacc uccauagaag acaccgggac       60

cgauccagcc uccgcggccg ggaacggugc auuggaacgc ggauuccccg ugccaagagu      120

gacucaccgu ccuugacacg augcagcggu ccccgcucga aaaggccagu gucgugucca      180

aacucuucuu cucauggacu cggccuaucc uuagaaaggg guaucggcag aggcuugagu      240

ugucugacau cuaccagauc cccucgguag auucggcgga uaaccucucg gagaagcucg      300

aacgggaaug ggaccgcgaa cucgcgucua agaaaaaccc gaagcucauc aacgcacuga      360

gaaggugcuu cuucuggcgg uucauguucu acgguaucuu cuuguaucuc ggggagguca      420

caaaagcagu ccaaccccug uuguuggguc gcauuaucgc cucguacgac cccgauaaca      480

aagaagaacg gagcaucgcg aucuaccucg ggaucggacu guguuugcuu uucaucguca      540

gaacacuuuu guugcaucca gcaaucuucg gccuccauca caucgguaug cagaugcgaa      600

ucgcuauguu uagcuugauc uacaaaaaga cacugaaacu cucgucgcgg guguuggaua      660

agauuuccau cggucaguug gugucccugc uuaguaauaa ccucaacaaa uucgaugagg      720

gacuggcgcu ggcacauuuc guguggauug ccccguugca agucgcccuu uugaugggcc      780

uuauuuggga gcuguugcag gcaucugccu uuuguggccu gggauuucug auuguguugg      840

cauuguuuca ggcugggcuu gggcggauga ugaugaagua ucgcgaccag agagcgggua      900

aaaucucgga aagacucguc aucacuucgg aaaugaucga aaacauccag ucggucaaag      960

ccuauugcug ggaagaagcu auggagaaga ugauugaaaa ccuccgccaa acugagcuga     1020

aacugacccg caaggcggcg uauguccggu auuucaauuc gucagcguuc uucuuuuccg     1080

gguucuucgu ugucuuucuc ucgguuuugc cuuaugccuu gauuaagggg auuauccucc     1140

gcaagauuuu caccacgauu ucguucugca uuguauugcg cauggcagug acacggcaau     1200

uuccgugggc cgugcagaca ugguaugacu cgcuuggagc gaucaacaaa auccaagacu     1260

ucuugcaaaa gcaagaguac aagacccugg aguacaaucu uacuacuacg gagguaguaa     1320

uggagaaugu gacggcuuuu ugggaagagg guuuuggaga acuguuugag aaagcaaagc     1380

agaauaacaa caaccgcaag accucaaaug gggacgauuc ccuguuuuuc ucgaacuucu     1440

cccugcucgg aacacccgug uugaaggaca ucaauuucaa gauugagagg ggacagcuuc     1500

ucgcgguagc gggaagcacu ggugcgggaa aaacuagccu cuugauggug auuauggggg     1560

agcuugagcc cagcgagggg aagauuaaac acuccgggcg uaucucauuc uguagccagu     1620

uuucauggau caugcccgga accauuaaag agaacaucau uuucggagua uccuaugaug     1680

aguaccgaua cagaucgguc auuaaggcgu gccaguugga agaggacauu ucuaaguucg     1740

ccgagaagga uaacaucguc uugggagaag gggguauuac auugucggga gggcagcgag     1800

cgcggaucag ccucgcgaga gcgguauaca aagaugcaga uuuguaucug cuugauucac     1860

cguuuggaua ccucgacgua uugacagaaa aagaaaucuu cgagucgugc guguguaaac     1920

uuauggcuaa uaagacgaga auccugguga caucaaaaau ggaacaccuu aagaaggcgg     1980

acaagauccu gauccuccac gaaggaucgu ccuacuuuua cggcacuuuc ucagaguugc     2040

aaaacuugca gccggacuuc ucaagcaaac ucauggggug ugacucauuc gaccaguuca     2100

gcgcggaacg gcggaacucg aucuugacgg aaacgcugca ccgauucucg cuugagggug     2160

augccccggu aucguggacc gagacaaaga agcagucguu uaagcagaca ggagaauuug     2220

gugagaaaag aaagaacagu aucuugaauc cuauuaacuc aauucgcaag uucucaaucg     2280

uccagaaaac uccacugcag augaauggaa uugaagagga uucggacgaa ccccuggagc     2340

gcaggcuuag ccucgugccg gauucagagc aaggggaggc cauucuuccc cggauuucgg     2400

ugauuucaac cggaccuaca cuucaggcga ggcgaaggca auccgugcuc aaccucauga     2460

cgcauucggu aaaccagggg caaaacauuc accgcaaaac gacggccuca acgagaaaag     2520

ugucacuugc accccaggcg aauuugacug aacucgacau cuacagccgu aggcuuucgc     2580

aagaaaccgg acuugagauc agcgaagaaa ucaaugaaga agauuugaaa gaguguuucu     2640

uugaugacau ggaaucaauc ccagcgguga caacguggaa cacauacuug cguuacauca     2700

cggugcacaa guccuugauu uucguccuca ucuggugucu cgugaucuuu cucgcugagg     2760

ucgcagcguc acuugugguc cucuggcugc uugguaauac gcccuugcaa gacaaaggca     2820

auucuacaca cucaagaaac aauuccuaug ccgugauuau cacuucuaca agcucguauu     2880

acguguuuua caucuacgua ggaguggccg acacucugcu cgcgaugggu uucuuccgag     2940

gacucccacu cguucacacg cuuaucacug ucuccaagau ucuccaccau aagaugcuuc     3000

auagcguacu gcaggcuccc auguccaccu ugaauacgcu caaggcggga gguauuuuga     3060

aucgcuucuc aaaagauauu gcaauuuugg augaccuucu gccccugacg aucuucgacu     3120

ucauccaguu guugcugauc gugauugggg cuauugcagu agucgcuguc cuccagccuu     3180

acauuuuugu cgcgaccguu ccggugaucg uggcguuuau caugcugcgg gccuauuucu     3240

ugcagacguc acagcagcuu aagcaacugg agucugaagg gaggucgccu aucuuuacgc     3300

aucuugugac caguuugaag ggauugugga cguugcgcgc cuuuggcagg cagcccuacu     3360

uugaaacacu guuccacaaa gcgcugaauc uccauacggc aaauugguuu uuguauuuga     3420

guacccuccg augguuucag augcgcauug agaugauuuu ugugaucuuc uuuaucgcgg     3480

ugacuuuuau cuccaucuug accacgggag agggcgaggg acgggucggu auuauccuga     3540

cacucgccau gaacauuaug agcacuuugc agugggcagu gaacagcucg auugaugugg     3600

auagccugau gagguccguu ucgagggucu uuaaguucau cgacaugccg acggagggaa     3660

agcccacaaa aaguacgaaa cccuauaaga augggcaauu gaguaaggua augaucaucg     3720

agaacaguca cgugaagaag gaugacaucu ggccuagcgg gggucagaug accgugaagg     3780

accugacggc aaaauacacc gagggaggga acgcaauccu ugaaaacauc ucguucagca     3840

uuagccccgg ucagcgugug ggguugcucg ggaggaccgg gucaggaaaa ucgacguugc     3900

ugucggccuu cuugagacuu cugaauacag agggugagau ccagaucgac ggcguuucgu     3960

gggauagcau caccuugcag caguggcgga aagcguuugg aguaaucccc caaaaggucu     4020

uuaucuuuag cggaaccuuc cgaaagaauc ucgauccuua ugaacagugg ucagaucaag     4080

agauuuggaa agucgcggac gagguuggcc uucggagugu aaucgagcag uuuccgggaa     4140

aacucgacuu uguccuugua gaugggggau gcguccuguc gcaugggcac aagcagcuca     4200

ugugccuggc gcgauccguc cucucuaaag cgaaaauucu ucucuuggau gaaccuucgg     4260

cccaucugga cccgguaacg uaucagauca ucagaaggac acuuaagcag gcguuugccg     4320

acugcacggu gauucucugu gagcaucgua ucgaggccau gcucgaaugc cagcaauuuc     4380

uugucaucga agagaauaag guccgccagu acgacuccau ccagaagcug cuuaaugaga     4440

gaucauuguu ccggcaggcg auuucaccau ccgauagggu gaaacuuuuu ccacacagaa     4500

auucgucgaa gugcaagucc aaaccgcaga ucgcggccuu gaaagaagag acugaagaag     4560

aaguucaaga cacgcgucuu uaaggguggc aucccuguga ccccucccca gugccucucc     4620

uggcccugga aguugccacu ccagugccca ccagccuugu ccuaauaaaa uuaaguugca     4680

ucaaagcu                                                              4688


