                               SEQUENCE LISTING

<110> TUCKER, ERIK I.
      MARKWAY, BRANDON D.
      WALLISCH, MICHAEL N.
      VERBOUT, NORAH G.
 
<120> E-WE THROMBIN ANALOG AND FIBRINOLYTIC COMBINATION

<130> ARB001PCT

<140>
<141>

<150> 62/416,631
<151> 2016-11-02

<160> 24    

<170> PatentIn version 3.5

<210> 1
<211> 295
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Thr Phe Gly Ser Gly Glu Ala Asp Cys Gly Leu Arg Pro Leu Phe Glu 
1               5                   10                  15      


Lys Lys Ser Leu Glu Asp Lys Thr Glu Arg Glu Leu Leu Glu Ser Tyr 
            20                  25                  30          


Ile Asp Gly Arg Ile Val Glu Gly Ser Asp Ala Glu Ile Gly Met Ser 
        35                  40                  45              


Pro Trp Gln Val Met Leu Phe Arg Lys Ser Pro Gln Glu Leu Leu Cys 
    50                  55                  60                  


Gly Ala Ser Leu Ile Ser Asp Arg Trp Val Leu Thr Ala Ala His Cys 
65                  70                  75                  80  


Leu Leu Tyr Pro Pro Trp Asp Lys Asn Phe Thr Glu Asn Asp Leu Leu 
                85                  90                  95      


Val Arg Ile Gly Lys His Ser Arg Thr Arg Tyr Glu Arg Asn Ile Glu 
            100                 105                 110         


Lys Ile Ser Met Leu Glu Lys Ile Tyr Ile His Pro Arg Tyr Asn Trp 
        115                 120                 125             


Arg Glu Asn Leu Asp Arg Asp Ile Ala Leu Met Lys Leu Lys Lys Pro 
    130                 135                 140                 


Val Ala Phe Ser Asp Tyr Ile His Pro Val Cys Leu Pro Asp Arg Glu 
145                 150                 155                 160 


Thr Ala Ala Ser Leu Leu Gln Ala Gly Tyr Lys Gly Arg Val Thr Gly 
                165                 170                 175     


Trp Gly Asn Leu Lys Glu Thr Trp Thr Ala Asn Val Gly Lys Gly Gln 
            180                 185                 190         


Pro Ser Val Leu Gln Val Val Asn Leu Pro Ile Val Glu Arg Pro Val 
        195                 200                 205             


Cys Lys Asp Ser Thr Arg Ile Arg Ile Thr Asp Asn Met Phe Cys Ala 
    210                 215                 220                 


Gly Tyr Lys Pro Asp Glu Gly Lys Arg Gly Asp Ala Cys Glu Gly Asp 
225                 230                 235                 240 


Ser Gly Gly Pro Phe Val Met Lys Ser Pro Phe Asn Asn Arg Trp Tyr 
                245                 250                 255     


Gln Met Gly Ile Val Ser Ala Gly Ala Gly Cys Asp Arg Asp Gly Lys 
            260                 265                 270         


Tyr Gly Phe Tyr Thr His Val Phe Arg Leu Lys Lys Trp Ile Gln Lys 
        275                 280                 285             


Val Ile Asp Gln Phe Gly Glu 
    290                 295 


<210> 2
<211> 295
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Thr Phe Gly Ser Gly Glu Ala Asp Cys Gly Leu Arg Pro Leu Phe Glu 
1               5                   10                  15      


Lys Lys Ser Leu Glu Asp Lys Thr Glu Arg Glu Leu Leu Glu Ser Tyr 
            20                  25                  30          


Ile Asp Gly Arg Ile Val Glu Gly Ser Asp Ala Glu Ile Gly Met Ser 
        35                  40                  45              


Pro Trp Gln Val Met Leu Phe Arg Lys Ser Pro Gln Glu Leu Leu Cys 
    50                  55                  60                  


Gly Ala Ser Leu Ile Ser Asp Arg Trp Val Leu Thr Ala Ala His Cys 
65                  70                  75                  80  


Leu Leu Tyr Pro Pro Trp Asp Lys Asn Phe Thr Glu Asn Asp Leu Leu 
                85                  90                  95      


Val Arg Ile Gly Lys His Ser Arg Thr Arg Tyr Glu Arg Asn Ile Glu 
            100                 105                 110         


Lys Ile Ser Met Leu Glu Lys Ile Tyr Ile His Pro Arg Tyr Asn Trp 
        115                 120                 125             


Arg Glu Asn Leu Asp Arg Asp Ile Ala Leu Met Lys Leu Lys Lys Pro 
    130                 135                 140                 


Val Ala Phe Ser Asp Tyr Ile His Pro Val Cys Leu Pro Asp Arg Glu 
145                 150                 155                 160 


Thr Ala Ala Ser Leu Leu Gln Ala Gly Tyr Lys Gly Arg Val Thr Gly 
                165                 170                 175     


Trp Gly Asn Leu Lys Glu Thr Trp Thr Ala Asn Val Gly Lys Gly Gln 
            180                 185                 190         


Pro Ser Val Leu Gln Val Val Asn Leu Pro Ile Val Glu Arg Pro Val 
        195                 200                 205             


Cys Lys Asp Ser Thr Arg Ile Arg Ile Thr Asp Asn Met Phe Cys Ala 
    210                 215                 220                 


Gly Tyr Lys Pro Asp Glu Gly Lys Arg Gly Asp Ala Cys Glu Gly Asp 
225                 230                 235                 240 


Ser Gly Gly Pro Phe Val Met Lys Ser Pro Phe Asn Asn Arg Trp Tyr 
                245                 250                 255     


Gln Met Gly Ile Val Ser Ala Gly Ala Gly Cys Asp Arg Asp Gly Lys 
            260                 265                 270         


Tyr Gly Phe Tyr Thr His Val Phe Arg Leu Lys Lys Trp Ile Gln Lys 
        275                 280                 285             


Val Ile Asp Gln Phe Gly Glu 
    290                 295 


<210> 3
<211> 295
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Thr Phe Gly Ser Gly Glu Ala Asp Cys Gly Leu Arg Pro Leu Phe Glu 
1               5                   10                  15      


Lys Lys Ser Leu Glu Asp Lys Thr Glu Arg Glu Leu Leu Glu Ser Tyr 
            20                  25                  30          


Ile Asp Gly Arg Ile Val Glu Gly Ser Asp Ala Glu Ile Gly Met Ser 
        35                  40                  45              


Pro Trp Gln Val Met Leu Phe Arg Lys Ser Pro Gln Glu Leu Leu Cys 
    50                  55                  60                  


Gly Ala Ser Leu Ile Ser Asp Arg Trp Val Leu Thr Ala Ala His Cys 
65                  70                  75                  80  


Leu Leu Tyr Pro Pro Trp Asp Lys Asn Phe Thr Glu Asn Asp Leu Leu 
                85                  90                  95      


Val Arg Ile Gly Lys His Ser Arg Thr Arg Tyr Glu Arg Asn Ile Glu 
            100                 105                 110         


Lys Ile Ser Met Leu Glu Lys Ile Tyr Ile His Pro Arg Tyr Asn Trp 
        115                 120                 125             


Arg Glu Asn Leu Asp Arg Asp Ile Ala Leu Met Lys Leu Lys Lys Pro 
    130                 135                 140                 


Val Ala Phe Ser Asp Tyr Ile His Pro Val Cys Leu Pro Asp Arg Glu 
145                 150                 155                 160 


Thr Ala Ala Ser Leu Leu Gln Ala Gly Tyr Lys Gly Arg Val Thr Gly 
                165                 170                 175     


Trp Gly Asn Leu Lys Glu Thr Trp Thr Ala Asn Val Gly Lys Gly Gln 
            180                 185                 190         


Pro Ser Val Leu Gln Val Val Asn Leu Pro Ile Val Glu Arg Pro Val 
        195                 200                 205             


Cys Lys Asp Ser Thr Arg Ile Arg Ile Thr Asp Asn Met Phe Cys Ala 
    210                 215                 220                 


Gly Tyr Lys Pro Asp Glu Gly Lys Arg Gly Asp Ala Cys Glu Gly Asp 
225                 230                 235                 240 


Ser Gly Gly Pro Phe Val Met Lys Ser Pro Phe Asn Asn Arg Trp Tyr 
                245                 250                 255     


Gln Met Gly Ile Val Ser Trp Gly Glu Gly Cys Asp Arg Asp Gly Lys 
            260                 265                 270         


Tyr Gly Phe Tyr Thr His Val Phe Arg Leu Lys Lys Trp Ile Gln Lys 
        275                 280                 285             


Val Ile Asp Gln Phe Gly Glu 
    290                 295 


<210> 4
<211> 622
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Ala His Val Arg Gly Leu Gln Leu Pro Gly Cys Leu Ala Leu Ala 
1               5                   10                  15      


Ala Leu Cys Ser Leu Val His Ser Gln His Val Phe Leu Ala Pro Gln 
            20                  25                  30          


Gln Ala Arg Ser Leu Leu Gln Arg Val Arg Arg Ala Asn Thr Phe Leu 
        35                  40                  45              


Glu Glu Val Arg Lys Gly Asn Leu Glu Arg Glu Cys Val Glu Glu Thr 
    50                  55                  60                  


Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu Ser Ser Thr Ala Thr 
65                  70                  75                  80  


Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys Glu Thr Ala Arg Thr Pro 
                85                  90                  95      


Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly Asn Cys Ala Glu Gly Leu 
            100                 105                 110         


Gly Thr Asn Tyr Arg Gly His Val Asn Ile Thr Arg Ser Gly Ile Glu 
        115                 120                 125             


Cys Gln Leu Trp Arg Ser Arg Tyr Pro His Lys Pro Glu Ile Asn Ser 
    130                 135                 140                 


Thr Thr His Pro Gly Ala Asp Leu Gln Glu Asn Phe Cys Arg Asn Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr Thr Thr Asp Pro Thr Val 
                165                 170                 175     


Arg Arg Gln Glu Cys Ser Ile Pro Val Cys Gly Gln Asp Gln Val Thr 
            180                 185                 190         


Val Ala Met Thr Pro Arg Ser Glu Gly Ser Ser Val Asn Leu Ser Pro 
        195                 200                 205             


Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln Gln Tyr Gln Gly Arg 
    210                 215                 220                 


Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu Ala Trp Ala Ser Ala 
225                 230                 235                 240 


Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe Asn Ser Ala Val Gln 
                245                 250                 255     


Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly Asp Glu Glu Gly Val 
            260                 265                 270         


Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe Gly Tyr Cys Asp Leu 
        275                 280                 285             


Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr Gly Asp Gly Leu Asp 
    290                 295                 300                 


Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr Ala Thr Ser Glu Tyr 
305                 310                 315                 320 


Gln Thr Phe Phe Asn Pro Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys 
                325                 330                 335     


Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu 
            340                 345                 350         


Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser 
        355                 360                 365             


Asp Ala Glu Ile Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys 
    370                 375                 380                 


Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp 
385                 390                 395                 400 


Val Leu Thr Ala Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn 
                405                 410                 415     


Phe Thr Glu Asn Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr 
            420                 425                 430         


Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr 
        435                 440                 445             


Ile His Pro Arg Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala 
    450                 455                 460                 


Leu Met Lys Leu Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro 
465                 470                 475                 480 


Val Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly 
                485                 490                 495     


Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr 
            500                 505                 510         


Ala Asn Val Gly Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu 
        515                 520                 525             


Pro Ile Val Glu Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile 
    530                 535                 540                 


Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg 
545                 550                 555                 560 


Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser 
                565                 570                 575     


Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile Val Ser Trp Gly Glu 
            580                 585                 590         


Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg 
        595                 600                 605             


Leu Lys Lys Trp Ile Gln Lys Val Ile Asp Gln Phe Gly Glu 
    610                 615                 620         


<210> 5
<211> 622
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Ala His Val Arg Gly Leu Gln Leu Pro Gly Cys Leu Ala Leu Ala 
1               5                   10                  15      


Ala Leu Cys Ser Leu Val His Ser Gln His Val Phe Leu Ala Pro Gln 
            20                  25                  30          


Gln Ala Arg Ser Leu Leu Gln Arg Val Arg Arg Ala Asn Thr Phe Leu 
        35                  40                  45              


Glu Glu Val Arg Lys Gly Asn Leu Glu Arg Glu Cys Val Glu Glu Thr 
    50                  55                  60                  


Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu Ser Ser Thr Ala Thr 
65                  70                  75                  80  


Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys Glu Thr Ala Arg Thr Pro 
                85                  90                  95      


Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly Asn Cys Ala Glu Gly Leu 
            100                 105                 110         


Gly Thr Asn Tyr Arg Gly His Val Asn Ile Thr Arg Ser Gly Ile Glu 
        115                 120                 125             


Cys Gln Leu Trp Arg Ser Arg Tyr Pro His Lys Pro Glu Ile Asn Ser 
    130                 135                 140                 


Thr Thr His Pro Gly Ala Asp Leu Gln Glu Asn Phe Cys Arg Asn Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr Thr Thr Asp Pro Thr Val 
                165                 170                 175     


Arg Arg Gln Glu Cys Ser Ile Pro Val Cys Gly Gln Asp Gln Val Thr 
            180                 185                 190         


Val Ala Met Thr Pro Arg Ser Glu Gly Ser Ser Val Asn Leu Ser Pro 
        195                 200                 205             


Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln Gln Tyr Gln Gly Arg 
    210                 215                 220                 


Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu Ala Trp Ala Ser Ala 
225                 230                 235                 240 


Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe Asn Ser Ala Val Gln 
                245                 250                 255     


Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly Asp Glu Glu Gly Val 
            260                 265                 270         


Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe Gly Tyr Cys Asp Leu 
        275                 280                 285             


Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr Gly Asp Gly Leu Asp 
    290                 295                 300                 


Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr Ala Thr Ser Glu Tyr 
305                 310                 315                 320 


Gln Thr Phe Phe Asp Gly Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys 
                325                 330                 335     


Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu 
            340                 345                 350         


Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser 
        355                 360                 365             


Asp Ala Glu Ile Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys 
    370                 375                 380                 


Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp 
385                 390                 395                 400 


Val Leu Thr Ala Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn 
                405                 410                 415     


Phe Thr Glu Asn Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr 
            420                 425                 430         


Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr 
        435                 440                 445             


Ile His Pro Arg Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala 
    450                 455                 460                 


Leu Met Lys Leu Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro 
465                 470                 475                 480 


Val Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly 
                485                 490                 495     


Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr 
            500                 505                 510         


Ala Asn Val Gly Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu 
        515                 520                 525             


Pro Ile Val Glu Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile 
    530                 535                 540                 


Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg 
545                 550                 555                 560 


Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser 
                565                 570                 575     


Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile Val Ser Ala Gly Ala 
            580                 585                 590         


Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg 
        595                 600                 605             


Leu Lys Lys Trp Ile Gln Lys Val Ile Asp Gln Phe Gly Glu 
    610                 615                 620         


<210> 6
<211> 308
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Thr Ala Thr Ser Glu Tyr Gln Thr Phe Phe Asp Gly Arg Thr Phe Gly 
1               5                   10                  15      


Ser Gly Glu Ala Asp Cys Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser 
            20                  25                  30          


Leu Glu Asp Lys Thr Glu Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly 
        35                  40                  45              


Arg Ile Val Glu Gly Ser Asp Ala Glu Ile Gly Met Ser Pro Trp Gln 
    50                  55                  60                  


Val Met Leu Phe Arg Lys Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser 
65                  70                  75                  80  


Leu Ile Ser Asp Arg Trp Val Leu Thr Ala Ala His Cys Leu Leu Tyr 
                85                  90                  95      


Pro Pro Trp Asp Lys Asn Phe Thr Glu Asn Asp Leu Leu Val Arg Ile 
            100                 105                 110         


Gly Lys His Ser Arg Thr Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser 
        115                 120                 125             


Met Leu Glu Lys Ile Tyr Ile His Pro Arg Tyr Asn Trp Arg Glu Asn 
    130                 135                 140                 


Leu Asp Arg Asp Ile Ala Leu Met Lys Leu Lys Lys Pro Val Ala Phe 
145                 150                 155                 160 


Ser Asp Tyr Ile His Pro Val Cys Leu Pro Asp Arg Glu Thr Ala Ala 
                165                 170                 175     


Ser Leu Leu Gln Ala Gly Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn 
            180                 185                 190         


Leu Lys Glu Thr Trp Thr Ala Asn Val Gly Lys Gly Gln Pro Ser Val 
        195                 200                 205             


Leu Gln Val Val Asn Leu Pro Ile Val Glu Arg Pro Val Cys Lys Asp 
    210                 215                 220                 


Ser Thr Arg Ile Arg Ile Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys 
225                 230                 235                 240 


Pro Asp Glu Gly Lys Arg Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly 
                245                 250                 255     


Pro Phe Val Met Lys Ser Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly 
            260                 265                 270         


Ile Val Ser Ala Gly Ala Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe 
        275                 280                 285             


Tyr Thr His Val Phe Arg Leu Lys Lys Trp Ile Gln Lys Val Ile Asp 
    290                 295                 300                 


Gln Phe Gly Glu 
305             


<210> 7
<211> 622
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Met Ala His Val Arg Gly Leu Gln Leu Pro Gly Cys Leu Ala Leu Ala 
1               5                   10                  15      


Ala Leu Cys Ser Leu Val His Ser Gln His Val Phe Leu Ala Pro Gln 
            20                  25                  30          


Gln Ala Arg Ser Leu Leu Gln Arg Val Arg Arg Ala Asn Thr Phe Leu 
        35                  40                  45              


Glu Glu Val Arg Lys Gly Asn Leu Glu Arg Glu Cys Val Glu Glu Thr 
    50                  55                  60                  


Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu Ser Ser Thr Ala Thr 
65                  70                  75                  80  


Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys Glu Thr Ala Arg Thr Pro 
                85                  90                  95      


Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly Asn Cys Ala Glu Gly Leu 
            100                 105                 110         


Gly Thr Asn Tyr Arg Gly His Val Asn Ile Thr Arg Ser Gly Ile Glu 
        115                 120                 125             


Cys Gln Leu Trp Arg Ser Arg Tyr Pro His Lys Pro Glu Ile Asn Ser 
    130                 135                 140                 


Thr Thr His Pro Gly Ala Asp Leu Gln Glu Asn Phe Cys Arg Asn Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr Thr Thr Asp Pro Thr Val 
                165                 170                 175     


Arg Arg Gln Glu Cys Ser Ile Pro Val Cys Gly Gln Asp Gln Val Thr 
            180                 185                 190         


Val Ala Met Thr Pro Arg Ser Glu Gly Ser Ser Val Asn Leu Ser Pro 
        195                 200                 205             


Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln Gln Tyr Gln Gly Arg 
    210                 215                 220                 


Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu Ala Trp Ala Ser Ala 
225                 230                 235                 240 


Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe Asn Ser Ala Val Gln 
                245                 250                 255     


Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly Asp Glu Glu Gly Val 
            260                 265                 270         


Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe Gly Tyr Cys Asp Leu 
        275                 280                 285             


Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr Gly Asp Gly Leu Asp 
    290                 295                 300                 


Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr Ala Thr Ser Glu Tyr 
305                 310                 315                 320 


Gln Thr Phe Phe Asp Gly Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys 
                325                 330                 335     


Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu 
            340                 345                 350         


Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser 
        355                 360                 365             


Asp Ala Glu Ile Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys 
    370                 375                 380                 


Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp 
385                 390                 395                 400 


Val Leu Thr Ala Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn 
                405                 410                 415     


Phe Thr Glu Asn Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr 
            420                 425                 430         


Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr 
        435                 440                 445             


Ile His Pro Arg Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala 
    450                 455                 460                 


Leu Met Lys Leu Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro 
465                 470                 475                 480 


Val Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly 
                485                 490                 495     


Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr 
            500                 505                 510         


Ala Asn Val Gly Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu 
        515                 520                 525             


Pro Ile Val Glu Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile 
    530                 535                 540                 


Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg 
545                 550                 555                 560 


Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser 
                565                 570                 575     


Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile Val Ser Trp Gly Glu 
            580                 585                 590         


Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg 
        595                 600                 605             


Leu Lys Lys Trp Ile Gln Lys Val Ile Asp Gln Phe Gly Glu 
    610                 615                 620         


<210> 8
<211> 308
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Thr Ala Thr Ser Glu Tyr Gln Thr Phe Phe Asp Gly Arg Thr Phe Gly 
1               5                   10                  15      


Ser Gly Glu Ala Asp Cys Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser 
            20                  25                  30          


Leu Glu Asp Lys Thr Glu Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly 
        35                  40                  45              


Arg Ile Val Glu Gly Ser Asp Ala Glu Ile Gly Met Ser Pro Trp Gln 
    50                  55                  60                  


Val Met Leu Phe Arg Lys Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser 
65                  70                  75                  80  


Leu Ile Ser Asp Arg Trp Val Leu Thr Ala Ala His Cys Leu Leu Tyr 
                85                  90                  95      


Pro Pro Trp Asp Lys Asn Phe Thr Glu Asn Asp Leu Leu Val Arg Ile 
            100                 105                 110         


Gly Lys His Ser Arg Thr Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser 
        115                 120                 125             


Met Leu Glu Lys Ile Tyr Ile His Pro Arg Tyr Asn Trp Arg Glu Asn 
    130                 135                 140                 


Leu Asp Arg Asp Ile Ala Leu Met Lys Leu Lys Lys Pro Val Ala Phe 
145                 150                 155                 160 


Ser Asp Tyr Ile His Pro Val Cys Leu Pro Asp Arg Glu Thr Ala Ala 
                165                 170                 175     


Ser Leu Leu Gln Ala Gly Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn 
            180                 185                 190         


Leu Lys Glu Thr Trp Thr Ala Asn Val Gly Lys Gly Gln Pro Ser Val 
        195                 200                 205             


Leu Gln Val Val Asn Leu Pro Ile Val Glu Arg Pro Val Cys Lys Asp 
    210                 215                 220                 


Ser Thr Arg Ile Arg Ile Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys 
225                 230                 235                 240 


Pro Asp Glu Gly Lys Arg Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly 
                245                 250                 255     


Pro Phe Val Met Lys Ser Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly 
            260                 265                 270         


Ile Val Ser Trp Gly Glu Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe 
        275                 280                 285             


Tyr Thr His Val Phe Arg Leu Lys Lys Trp Ile Gln Lys Val Ile Asp 
    290                 295                 300                 


Gln Phe Gly Glu 
305             


<210> 9
<211> 301
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Thr Ala Thr Ser Glu Tyr Gln Thr Phe Phe Asp Gly Arg Thr Phe Gly 
1               5                   10                  15      


Ser Gly Glu Ala Asp Cys Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser 
            20                  25                  30          


Leu Glu Asp Lys Thr Glu Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly 
        35                  40                  45              


Arg Ile Val Glu Gly Ser Asp Ala Glu Ile Gly Met Ser Pro Trp Gln 
    50                  55                  60                  


Val Met Leu Phe Arg Lys Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser 
65                  70                  75                  80  


Leu Ile Ser Asp Arg Trp Val Leu Thr Ala Ala His Cys Leu Leu Tyr 
                85                  90                  95      


Pro Pro Trp Asp Lys Asn Phe Thr Glu Asn Asp Leu Leu Val Arg Ile 
            100                 105                 110         


Gly Lys His Ser Arg Thr Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser 
        115                 120                 125             


Met Leu Glu Lys Ile Tyr Ile His Pro Arg Tyr Asn Trp Arg Glu Asn 
    130                 135                 140                 


Leu Asp Arg Asp Ile Ala Leu Met Lys Leu Lys Lys Pro Val Ala Phe 
145                 150                 155                 160 


Ser Asp Tyr Ile His Pro Val Cys Leu Pro Asp Arg Glu Thr Ala Ala 
                165                 170                 175     


Ser Leu Leu Gln Ala Gly Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn 
            180                 185                 190         


Leu Lys Gly Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu Pro 
        195                 200                 205             


Ile Val Glu Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile Thr 
    210                 215                 220                 


Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg Gly 
225                 230                 235                 240 


Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser Pro 
                245                 250                 255     


Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile Val Ser Trp Gly Glu Gly 
            260                 265                 270         


Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg Leu 
        275                 280                 285             


Lys Lys Trp Ile Gln Lys Val Ile Asp Gln Phe Gly Glu 
    290                 295                 300     


<210> 10
<211> 622
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Ala His Val Arg Gly Leu Gln Leu Pro Gly Cys Leu Ala Leu Ala 
1               5                   10                  15      


Ala Leu Cys Ser Leu Val His Ser Gln His Val Phe Leu Ala Pro Gln 
            20                  25                  30          


Gln Ala Arg Ser Leu Leu Gln Arg Val Arg Arg Ala Asn Thr Phe Leu 
        35                  40                  45              


Glu Glu Val Arg Lys Gly Asn Leu Glu Arg Glu Cys Val Glu Glu Thr 
    50                  55                  60                  


Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu Ser Ser Thr Ala Thr 
65                  70                  75                  80  


Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys Glu Thr Ala Arg Thr Pro 
                85                  90                  95      


Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly Asn Cys Ala Glu Gly Leu 
            100                 105                 110         


Gly Thr Asn Tyr Arg Gly His Val Asn Ile Thr Arg Ser Gly Ile Glu 
        115                 120                 125             


Cys Gln Leu Trp Arg Ser Arg Tyr Pro His Lys Pro Glu Ile Asn Ser 
    130                 135                 140                 


Thr Thr His Pro Gly Ala Asp Leu Gln Glu Asn Phe Cys Arg Asn Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr Thr Thr Asp Pro Thr Val 
                165                 170                 175     


Arg Arg Gln Glu Cys Ser Ile Pro Val Cys Gly Gln Asp Gln Val Thr 
            180                 185                 190         


Val Ala Met Thr Pro Arg Ser Glu Gly Ser Ser Val Asn Leu Ser Pro 
        195                 200                 205             


Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln Gln Tyr Gln Gly Arg 
    210                 215                 220                 


Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu Ala Trp Ala Ser Ala 
225                 230                 235                 240 


Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe Asn Ser Ala Val Gln 
                245                 250                 255     


Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly Asp Glu Glu Gly Val 
            260                 265                 270         


Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe Gly Tyr Cys Asp Leu 
        275                 280                 285             


Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr Gly Asp Gly Leu Asp 
    290                 295                 300                 


Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr Ala Thr Ser Glu Tyr 
305                 310                 315                 320 


Gln Thr Phe Phe Asn Pro Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys 
                325                 330                 335     


Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu 
            340                 345                 350         


Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser 
        355                 360                 365             


Asp Ala Glu Ile Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys 
    370                 375                 380                 


Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp 
385                 390                 395                 400 


Val Leu Thr Ala Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn 
                405                 410                 415     


Phe Thr Glu Asn Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr 
            420                 425                 430         


Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr 
        435                 440                 445             


Ile His Pro Arg Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala 
    450                 455                 460                 


Leu Met Lys Leu Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro 
465                 470                 475                 480 


Val Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly 
                485                 490                 495     


Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr 
            500                 505                 510         


Ala Asn Val Gly Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu 
        515                 520                 525             


Pro Ile Val Glu Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile 
    530                 535                 540                 


Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg 
545                 550                 555                 560 


Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser 
                565                 570                 575     


Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile Val Ser Ala Gly Ala 
            580                 585                 590         


Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg 
        595                 600                 605             


Leu Lys Lys Trp Ile Gln Lys Val Ile Asp Gln Phe Gly Glu 
    610                 615                 620         


<210> 11
<211> 308
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Thr Ala Thr Ser Glu Tyr Gln Thr Phe Phe Asn Pro Arg Thr Phe Gly 
1               5                   10                  15      


Ser Gly Glu Ala Asp Cys Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser 
            20                  25                  30          


Leu Glu Asp Lys Thr Glu Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly 
        35                  40                  45              


Arg Ile Val Glu Gly Ser Asp Ala Glu Ile Gly Met Ser Pro Trp Gln 
    50                  55                  60                  


Val Met Leu Phe Arg Lys Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser 
65                  70                  75                  80  


Leu Ile Ser Asp Arg Trp Val Leu Thr Ala Ala His Cys Leu Leu Tyr 
                85                  90                  95      


Pro Pro Trp Asp Lys Asn Phe Thr Glu Asn Asp Leu Leu Val Arg Ile 
            100                 105                 110         


Gly Lys His Ser Arg Thr Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser 
        115                 120                 125             


Met Leu Glu Lys Ile Tyr Ile His Pro Arg Tyr Asn Trp Arg Glu Asn 
    130                 135                 140                 


Leu Asp Arg Asp Ile Ala Leu Met Lys Leu Lys Lys Pro Val Ala Phe 
145                 150                 155                 160 


Ser Asp Tyr Ile His Pro Val Cys Leu Pro Asp Arg Glu Thr Ala Ala 
                165                 170                 175     


Ser Leu Leu Gln Ala Gly Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn 
            180                 185                 190         


Leu Lys Glu Thr Trp Thr Ala Asn Val Gly Lys Gly Gln Pro Ser Val 
        195                 200                 205             


Leu Gln Val Val Asn Leu Pro Ile Val Glu Arg Pro Val Cys Lys Asp 
    210                 215                 220                 


Ser Thr Arg Ile Arg Ile Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys 
225                 230                 235                 240 


Pro Asp Glu Gly Lys Arg Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly 
                245                 250                 255     


Pro Phe Val Met Lys Ser Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly 
            260                 265                 270         


Ile Val Ser Ala Gly Ala Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe 
        275                 280                 285             


Tyr Thr His Val Phe Arg Leu Lys Lys Trp Ile Gln Lys Val Ile Asp 
    290                 295                 300                 


Gln Phe Gly Glu 
305             


<210> 12
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Phe Asn Pro Arg Thr Phe 
1               5       


<210> 13
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Phe Asp Gly Arg Thr Phe 
1               5       


<210> 14
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Tyr Ile Asp Gly Arg Ile Val 
1               5           


<210> 15
<211> 298
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Asp Gly Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys Gly Leu Arg Pro 
1               5                   10                  15      


Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu Arg Glu Leu Leu 
            20                  25                  30          


Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser Asp Ala Glu Ile 
        35                  40                  45              


Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys Ser Pro Gln Glu 
    50                  55                  60                  


Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp Val Leu Thr Ala 
65                  70                  75                  80  


Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn Phe Thr Glu Asn 
                85                  90                  95      


Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr Arg Tyr Glu Arg 
            100                 105                 110         


Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr Ile His Pro Arg 
        115                 120                 125             


Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala Leu Met Lys Leu 
    130                 135                 140                 


Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro Val Cys Leu Pro 
145                 150                 155                 160 


Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly Tyr Lys Gly Arg 
                165                 170                 175     


Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr Ala Asn Val Gly 
            180                 185                 190         


Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu Pro Ile Val Glu 
        195                 200                 205             


Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile Thr Asp Asn Met 
    210                 215                 220                 


Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg Gly Asp Ala Cys 
225                 230                 235                 240 


Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser Pro Phe Asn Asn 
                245                 250                 255     


Arg Trp Tyr Gln Met Gly Ile Val Ser Ala Gly Ala Gly Cys Asp Arg 
            260                 265                 270         


Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg Leu Lys Lys Trp 
        275                 280                 285             


Ile Gln Lys Val Ile Asp Gln Phe Gly Glu 
    290                 295             


<210> 16
<211> 298
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Glu Gly Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys Gly Leu Arg Pro 
1               5                   10                  15      


Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu Arg Glu Leu Leu 
            20                  25                  30          


Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser Asp Ala Glu Ile 
        35                  40                  45              


Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys Ser Pro Gln Glu 
    50                  55                  60                  


Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp Val Leu Thr Ala 
65                  70                  75                  80  


Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn Phe Thr Glu Asn 
                85                  90                  95      


Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr Arg Tyr Glu Arg 
            100                 105                 110         


Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr Ile His Pro Arg 
        115                 120                 125             


Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala Leu Met Lys Leu 
    130                 135                 140                 


Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro Val Cys Leu Pro 
145                 150                 155                 160 


Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly Tyr Lys Gly Arg 
                165                 170                 175     


Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr Ala Asn Val Gly 
            180                 185                 190         


Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu Pro Ile Val Glu 
        195                 200                 205             


Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile Thr Asp Asn Met 
    210                 215                 220                 


Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg Gly Asp Ala Cys 
225                 230                 235                 240 


Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser Pro Phe Asn Asn 
                245                 250                 255     


Arg Trp Tyr Gln Met Gly Ile Val Ser Ala Gly Ala Gly Cys Asp Arg 
            260                 265                 270         


Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg Leu Lys Lys Trp 
        275                 280                 285             


Ile Gln Lys Val Ile Asp Gln Phe Gly Glu 
    290                 295             


<210> 17
<211> 298
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Asp Gly Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys Gly Leu Arg Pro 
1               5                   10                  15      


Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu Arg Glu Leu Leu 
            20                  25                  30          


Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser Asp Ala Glu Ile 
        35                  40                  45              


Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys Ser Pro Gln Glu 
    50                  55                  60                  


Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp Val Leu Thr Ala 
65                  70                  75                  80  


Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn Phe Thr Glu Asn 
                85                  90                  95      


Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr Arg Tyr Glu Arg 
            100                 105                 110         


Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr Ile His Pro Arg 
        115                 120                 125             


Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala Leu Met Lys Leu 
    130                 135                 140                 


Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro Val Cys Leu Pro 
145                 150                 155                 160 


Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly Tyr Lys Gly Arg 
                165                 170                 175     


Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr Ala Asn Val Gly 
            180                 185                 190         


Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu Pro Ile Val Glu 
        195                 200                 205             


Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile Thr Asp Asn Met 
    210                 215                 220                 


Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg Gly Asp Ala Cys 
225                 230                 235                 240 


Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser Pro Phe Asn Asn 
                245                 250                 255     


Arg Trp Tyr Gln Met Gly Ile Val Ser Trp Gly Glu Gly Cys Asp Arg 
            260                 265                 270         


Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg Leu Lys Lys Trp 
        275                 280                 285             


Ile Gln Lys Val Ile Asp Gln Phe Gly Glu 
    290                 295             


<210> 18
<211> 298
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Glu Gly Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys Gly Leu Arg Pro 
1               5                   10                  15      


Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu Arg Glu Leu Leu 
            20                  25                  30          


Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser Asp Ala Glu Ile 
        35                  40                  45              


Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys Ser Pro Gln Glu 
    50                  55                  60                  


Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp Val Leu Thr Ala 
65                  70                  75                  80  


Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn Phe Thr Glu Asn 
                85                  90                  95      


Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr Arg Tyr Glu Arg 
            100                 105                 110         


Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr Ile His Pro Arg 
        115                 120                 125             


Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala Leu Met Lys Leu 
    130                 135                 140                 


Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro Val Cys Leu Pro 
145                 150                 155                 160 


Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly Tyr Lys Gly Arg 
                165                 170                 175     


Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr Ala Asn Val Gly 
            180                 185                 190         


Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu Pro Ile Val Glu 
        195                 200                 205             


Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile Thr Asp Asn Met 
    210                 215                 220                 


Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg Gly Asp Ala Cys 
225                 230                 235                 240 


Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser Pro Phe Asn Asn 
                245                 250                 255     


Arg Trp Tyr Gln Met Gly Ile Val Ser Trp Gly Glu Gly Cys Asp Arg 
            260                 265                 270         


Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg Leu Lys Lys Trp 
        275                 280                 285             


Ile Gln Lys Val Ile Asp Gln Phe Gly Glu 
    290                 295             


<210> 19
<211> 579
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Ala Asn Thr Phe Leu Glu Glu Val Arg Lys Gly Asn Leu Glu Arg Glu 
1               5                   10                  15      


Cys Val Glu Glu Thr Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu 
            20                  25                  30          


Ser Ser Thr Ala Thr Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys Glu 
        35                  40                  45              


Thr Ala Arg Thr Pro Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly Asn 
    50                  55                  60                  


Cys Ala Glu Gly Leu Gly Thr Asn Tyr Arg Gly His Val Asn Ile Thr 
65                  70                  75                  80  


Arg Ser Gly Ile Glu Cys Gln Leu Trp Arg Ser Arg Tyr Pro His Lys 
                85                  90                  95      


Pro Glu Ile Asn Ser Thr Thr His Pro Gly Ala Asp Leu Gln Glu Asn 
            100                 105                 110         


Phe Cys Arg Asn Pro Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr Thr 
        115                 120                 125             


Thr Asp Pro Thr Val Arg Arg Gln Glu Cys Ser Ile Pro Val Cys Gly 
    130                 135                 140                 


Gln Asp Gln Val Thr Val Ala Met Thr Pro Arg Ser Glu Gly Ser Ser 
145                 150                 155                 160 


Val Asn Leu Ser Pro Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln 
                165                 170                 175     


Gln Tyr Gln Gly Arg Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu 
            180                 185                 190         


Ala Trp Ala Ser Ala Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe 
        195                 200                 205             


Asn Ser Ala Val Gln Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly 
    210                 215                 220                 


Asp Glu Glu Gly Val Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe 
225                 230                 235                 240 


Gly Tyr Cys Asp Leu Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr 
                245                 250                 255     


Gly Asp Gly Leu Asp Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr 
            260                 265                 270         


Ala Thr Ser Glu Tyr Gln Thr Phe Phe Asn Pro Arg Thr Phe Gly Ser 
        275                 280                 285             


Gly Glu Ala Asp Cys Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu 
    290                 295                 300                 


Glu Asp Lys Thr Glu Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg 
305                 310                 315                 320 


Ile Val Glu Gly Ser Asp Ala Glu Ile Gly Met Ser Pro Trp Gln Val 
                325                 330                 335     


Met Leu Phe Arg Lys Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu 
            340                 345                 350         


Ile Ser Asp Arg Trp Val Leu Thr Ala Ala His Cys Leu Leu Tyr Pro 
        355                 360                 365             


Pro Trp Asp Lys Asn Phe Thr Glu Asn Asp Leu Leu Val Arg Ile Gly 
    370                 375                 380                 


Lys His Ser Arg Thr Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met 
385                 390                 395                 400 


Leu Glu Lys Ile Tyr Ile His Pro Arg Tyr Asn Trp Arg Glu Asn Leu 
                405                 410                 415     


Asp Arg Asp Ile Ala Leu Met Lys Leu Lys Lys Pro Val Ala Phe Ser 
            420                 425                 430         


Asp Tyr Ile His Pro Val Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser 
        435                 440                 445             


Leu Leu Gln Ala Gly Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn Leu 
    450                 455                 460                 


Lys Glu Thr Trp Thr Ala Asn Val Gly Lys Gly Gln Pro Ser Val Leu 
465                 470                 475                 480 


Gln Val Val Asn Leu Pro Ile Val Glu Arg Pro Val Cys Lys Asp Ser 
                485                 490                 495     


Thr Arg Ile Arg Ile Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro 
            500                 505                 510         


Asp Glu Gly Lys Arg Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro 
        515                 520                 525             


Phe Val Met Lys Ser Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile 
    530                 535                 540                 


Val Ser Ala Gly Ala Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr 
545                 550                 555                 560 


Thr His Val Phe Arg Leu Lys Lys Trp Ile Gln Lys Val Ile Asp Gln 
                565                 570                 575     


Phe Gly Glu 


<210> 20
<211> 579
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Ala Asn Thr Phe Leu Glu Glu Val Arg Lys Gly Asn Leu Glu Arg Glu 
1               5                   10                  15      


Cys Val Glu Glu Thr Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu 
            20                  25                  30          


Ser Ser Thr Ala Thr Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys Glu 
        35                  40                  45              


Thr Ala Arg Thr Pro Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly Asn 
    50                  55                  60                  


Cys Ala Glu Gly Leu Gly Thr Asn Tyr Arg Gly His Val Asn Ile Thr 
65                  70                  75                  80  


Arg Ser Gly Ile Glu Cys Gln Leu Trp Arg Ser Arg Tyr Pro His Lys 
                85                  90                  95      


Pro Glu Ile Asn Ser Thr Thr His Pro Gly Ala Asp Leu Gln Glu Asn 
            100                 105                 110         


Phe Cys Arg Asn Pro Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr Thr 
        115                 120                 125             


Thr Asp Pro Thr Val Arg Arg Gln Glu Cys Ser Ile Pro Val Cys Gly 
    130                 135                 140                 


Gln Asp Gln Val Thr Val Ala Met Thr Pro Arg Ser Glu Gly Ser Ser 
145                 150                 155                 160 


Val Asn Leu Ser Pro Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln 
                165                 170                 175     


Gln Tyr Gln Gly Arg Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu 
            180                 185                 190         


Ala Trp Ala Ser Ala Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe 
        195                 200                 205             


Asn Ser Ala Val Gln Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly 
    210                 215                 220                 


Asp Glu Glu Gly Val Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe 
225                 230                 235                 240 


Gly Tyr Cys Asp Leu Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr 
                245                 250                 255     


Gly Asp Gly Leu Asp Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr 
            260                 265                 270         


Ala Thr Ser Glu Tyr Gln Thr Phe Phe Asp Gly Arg Thr Phe Gly Ser 
        275                 280                 285             


Gly Glu Ala Asp Cys Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu 
    290                 295                 300                 


Glu Asp Lys Thr Glu Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg 
305                 310                 315                 320 


Ile Val Glu Gly Ser Asp Ala Glu Ile Gly Met Ser Pro Trp Gln Val 
                325                 330                 335     


Met Leu Phe Arg Lys Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu 
            340                 345                 350         


Ile Ser Asp Arg Trp Val Leu Thr Ala Ala His Cys Leu Leu Tyr Pro 
        355                 360                 365             


Pro Trp Asp Lys Asn Phe Thr Glu Asn Asp Leu Leu Val Arg Ile Gly 
    370                 375                 380                 


Lys His Ser Arg Thr Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met 
385                 390                 395                 400 


Leu Glu Lys Ile Tyr Ile His Pro Arg Tyr Asn Trp Arg Glu Asn Leu 
                405                 410                 415     


Asp Arg Asp Ile Ala Leu Met Lys Leu Lys Lys Pro Val Ala Phe Ser 
            420                 425                 430         


Asp Tyr Ile His Pro Val Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser 
        435                 440                 445             


Leu Leu Gln Ala Gly Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn Leu 
    450                 455                 460                 


Lys Glu Thr Trp Thr Ala Asn Val Gly Lys Gly Gln Pro Ser Val Leu 
465                 470                 475                 480 


Gln Val Val Asn Leu Pro Ile Val Glu Arg Pro Val Cys Lys Asp Ser 
                485                 490                 495     


Thr Arg Ile Arg Ile Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro 
            500                 505                 510         


Asp Glu Gly Lys Arg Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro 
        515                 520                 525             


Phe Val Met Lys Ser Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile 
    530                 535                 540                 


Val Ser Ala Gly Ala Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr 
545                 550                 555                 560 


Thr His Val Phe Arg Leu Lys Lys Trp Ile Gln Lys Val Ile Asp Gln 
                565                 570                 575     


Phe Gly Glu 
            


<210> 21
<211> 579
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Ala Asn Thr Phe Leu Glu Glu Val Arg Lys Gly Asn Leu Glu Arg Glu 
1               5                   10                  15      


Cys Val Glu Glu Thr Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu 
            20                  25                  30          


Ser Ser Thr Ala Thr Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys Glu 
        35                  40                  45              


Thr Ala Arg Thr Pro Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly Asn 
    50                  55                  60                  


Cys Ala Glu Gly Leu Gly Thr Asn Tyr Arg Gly His Val Asn Ile Thr 
65                  70                  75                  80  


Arg Ser Gly Ile Glu Cys Gln Leu Trp Arg Ser Arg Tyr Pro His Lys 
                85                  90                  95      


Pro Glu Ile Asn Ser Thr Thr His Pro Gly Ala Asp Leu Gln Glu Asn 
            100                 105                 110         


Phe Cys Arg Asn Pro Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr Thr 
        115                 120                 125             


Thr Asp Pro Thr Val Arg Arg Gln Glu Cys Ser Ile Pro Val Cys Gly 
    130                 135                 140                 


Gln Asp Gln Val Thr Val Ala Met Thr Pro Arg Ser Glu Gly Ser Ser 
145                 150                 155                 160 


Val Asn Leu Ser Pro Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln 
                165                 170                 175     


Gln Tyr Gln Gly Arg Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu 
            180                 185                 190         


Ala Trp Ala Ser Ala Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe 
        195                 200                 205             


Asn Ser Ala Val Gln Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly 
    210                 215                 220                 


Asp Glu Glu Gly Val Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe 
225                 230                 235                 240 


Gly Tyr Cys Asp Leu Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr 
                245                 250                 255     


Gly Asp Gly Leu Asp Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr 
            260                 265                 270         


Ala Thr Ser Glu Tyr Gln Thr Phe Phe Glu Gly Arg Thr Phe Gly Ser 
        275                 280                 285             


Gly Glu Ala Asp Cys Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu 
    290                 295                 300                 


Glu Asp Lys Thr Glu Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg 
305                 310                 315                 320 


Ile Val Glu Gly Ser Asp Ala Glu Ile Gly Met Ser Pro Trp Gln Val 
                325                 330                 335     


Met Leu Phe Arg Lys Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu 
            340                 345                 350         


Ile Ser Asp Arg Trp Val Leu Thr Ala Ala His Cys Leu Leu Tyr Pro 
        355                 360                 365             


Pro Trp Asp Lys Asn Phe Thr Glu Asn Asp Leu Leu Val Arg Ile Gly 
    370                 375                 380                 


Lys His Ser Arg Thr Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met 
385                 390                 395                 400 


Leu Glu Lys Ile Tyr Ile His Pro Arg Tyr Asn Trp Arg Glu Asn Leu 
                405                 410                 415     


Asp Arg Asp Ile Ala Leu Met Lys Leu Lys Lys Pro Val Ala Phe Ser 
            420                 425                 430         


Asp Tyr Ile His Pro Val Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser 
        435                 440                 445             


Leu Leu Gln Ala Gly Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn Leu 
    450                 455                 460                 


Lys Glu Thr Trp Thr Ala Asn Val Gly Lys Gly Gln Pro Ser Val Leu 
465                 470                 475                 480 


Gln Val Val Asn Leu Pro Ile Val Glu Arg Pro Val Cys Lys Asp Ser 
                485                 490                 495     


Thr Arg Ile Arg Ile Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro 
            500                 505                 510         


Asp Glu Gly Lys Arg Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro 
        515                 520                 525             


Phe Val Met Lys Ser Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile 
    530                 535                 540                 


Val Ser Ala Gly Ala Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr 
545                 550                 555                 560 


Thr His Val Phe Arg Leu Lys Lys Trp Ile Gln Lys Val Ile Asp Gln 
                565                 570                 575     


Phe Gly Glu 
            


<210> 22
<211> 298
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Asp Gly Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys Gly Leu Arg Pro 
1               5                   10                  15      


Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu Arg Glu Leu Leu 
            20                  25                  30          


Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser Asp Ala Glu Ile 
        35                  40                  45              


Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys Ser Pro Gln Glu 
    50                  55                  60                  


Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp Val Leu Thr Ala 
65                  70                  75                  80  


Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn Phe Thr Glu Asn 
                85                  90                  95      


Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr Arg Tyr Glu Arg 
            100                 105                 110         


Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr Ile His Pro Arg 
        115                 120                 125             


Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala Leu Met Lys Leu 
    130                 135                 140                 


Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro Val Cys Leu Pro 
145                 150                 155                 160 


Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly Tyr Lys Gly Arg 
                165                 170                 175     


Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr Ala Asn Val Gly 
            180                 185                 190         


Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu Pro Ile Val Glu 
        195                 200                 205             


Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile Thr Asp Asn Met 
    210                 215                 220                 


Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg Gly Asp Ala Cys 
225                 230                 235                 240 


Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser Pro Phe Asn Asn 
                245                 250                 255     


Arg Trp Tyr Gln Met Gly Ile Val Ser Ala Gly Ala Gly Cys Asp Arg 
            260                 265                 270         


Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg Leu Lys Lys Trp 
        275                 280                 285             


Ile Gln Lys Val Ile Asp Gln Phe Gly Glu 
    290                 295             


<210> 23
<211> 298
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Glu Gly Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys Gly Leu Arg Pro 
1               5                   10                  15      


Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu Arg Glu Leu Leu 
            20                  25                  30          


Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser Asp Ala Glu Ile 
        35                  40                  45              


Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys Ser Pro Gln Glu 
    50                  55                  60                  


Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp Val Leu Thr Ala 
65                  70                  75                  80  


Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn Phe Thr Glu Asn 
                85                  90                  95      


Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr Arg Tyr Glu Arg 
            100                 105                 110         


Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr Ile His Pro Arg 
        115                 120                 125             


Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala Leu Met Lys Leu 
    130                 135                 140                 


Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro Val Cys Leu Pro 
145                 150                 155                 160 


Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly Tyr Lys Gly Arg 
                165                 170                 175     


Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr Ala Asn Val Gly 
            180                 185                 190         


Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu Pro Ile Val Glu 
        195                 200                 205             


Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile Thr Asp Asn Met 
    210                 215                 220                 


Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg Gly Asp Ala Cys 
225                 230                 235                 240 


Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser Pro Phe Asn Asn 
                245                 250                 255     


Arg Trp Tyr Gln Met Gly Ile Val Ser Ala Gly Ala Gly Cys Asp Arg 
            260                 265                 270         


Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg Leu Lys Lys Trp 
        275                 280                 285             


Ile Gln Lys Val Ile Asp Gln Phe Gly Glu 
    290                 295             


<210> 24
<211> 298
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Glu Gly Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys Gly Leu Arg Pro 
1               5                   10                  15      


Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu Arg Glu Leu Leu 
            20                  25                  30          


Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser Asp Ala Glu Ile 
        35                  40                  45              


Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys Ser Pro Gln Glu 
    50                  55                  60                  


Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp Val Leu Thr Ala 
65                  70                  75                  80  


Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn Phe Thr Glu Asn 
                85                  90                  95      


Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr Arg Tyr Glu Arg 
            100                 105                 110         


Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr Ile His Pro Arg 
        115                 120                 125             


Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala Leu Met Lys Leu 
    130                 135                 140                 


Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro Val Cys Leu Pro 
145                 150                 155                 160 


Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly Tyr Lys Gly Arg 
                165                 170                 175     


Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr Ala Asn Val Gly 
            180                 185                 190         


Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu Pro Ile Val Glu 
        195                 200                 205             


Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile Thr Asp Asn Met 
    210                 215                 220                 


Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg Gly Asp Ala Cys 
225                 230                 235                 240 


Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser Pro Phe Asn Asn 
                245                 250                 255     


Arg Trp Tyr Gln Met Gly Ile Val Ser Trp Gly Glu Gly Cys Asp Arg 
            260                 265                 270         


Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg Leu Lys Lys Trp 
        275                 280                 285             


Ile Gln Lys Val Ile Asp Gln Phe Gly Glu 
    290                 295             


