                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
       TAWFIK, Dan S.
       GOLDSMITH, Moshe
       ASHANI, Yaacov
       AGGARWAL, Nidhi
 
<120>  PHOSPHOTRIESTERASES FOR TREATING OR PREVENTING ORGANOPHOSPHATE 
       EXPOSURE ASSOCIATED DAMAGE

<130>  71453

<150>  US 62/419,980
<151>  2016-11-10

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  727
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MBP-PTE  wild type like S5 amino acid sequence

<400>  1

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365             


Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly Ile 
    370                 375                 380                 


Glu Gly Arg Ile Ser Glu Phe Ile Thr Asn Ser Gly Asp Arg Ile Asn 
385                 390                 395                 400 


Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala Gly Phe Thr Leu Thr 
                405                 410                 415     


His Glu His Ile Cys Gly Ser Ser Ala Gly Phe Leu Arg Ala Trp Pro 
            420                 425                 430         


Glu Phe Phe Gly Ser Arg Lys Ala Leu Ala Glu Lys Ala Val Arg Gly 
        435                 440                 445             


Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr Ile Val Asp Val Ser 
    450                 455                 460                 


Thr Phe Asp Ile Gly Arg Asp Val Ser Leu Leu Ala Glu Val Ser Arg 
465                 470                 475                 480 


Ala Ala Asp Val His Ile Val Ala Ala Thr Gly Leu Trp Phe Asp Pro 
                485                 490                 495     


Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu Leu Thr Gln Phe Phe 
            500                 505                 510         


Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr Gly Ile Arg Ala Gly 
        515                 520                 525             


Ile Ile Lys Val Ala Thr Thr Gly Lys Ala Thr Pro Phe Gln Glu Leu 
    530                 535                 540                 


Val Leu Arg Ala Ala Ala Arg Ala Ser Leu Ala Thr Gly Val Pro Val 
545                 550                 555                 560 


Thr Thr His Thr Ala Ala Ser Gln Arg Gly Gly Glu Gln Gln Ala Ala 
                565                 570                 575     


Ile Phe Glu Ser Glu Gly Leu Ser Pro Ser Arg Val Cys Ile Gly His 
            580                 585                 590         


Ser Asp Asp Thr Asp Asp Leu Ser Tyr Leu Thr Ala Leu Ala Ala Arg 
        595                 600                 605             


Gly Tyr Leu Ile Gly Leu Asp His Ile Pro His Ser Ala Ile Gly Leu 
    610                 615                 620                 


Glu Asp Asn Ala Ser Ala Ser Ala Leu Leu Gly Ile Arg Ser Trp Gln 
625                 630                 635                 640 


Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp Gln Gly Tyr Met Lys 
                645                 650                 655     


Gln Ile Leu Val Ser Asn Asp Trp Leu Phe Gly Phe Ser Ser Tyr Val 
            660                 665                 670         


Thr Asn Ile Met Asp Val Met Asp Ser Val Asn Pro Asp Gly Met Ala 
        675                 680                 685             


Phe Ile Pro Leu Arg Val Ile Pro Phe Leu Arg Glu Lys Gly Val Pro 
    690                 695                 700                 


Gln Glu Thr Leu Ala Gly Ile Thr Val Thr Asn Pro Ala Arg Phe Leu 
705                 710                 715                 720 


Ser Pro Thr Leu Arg Ala Ser 
                725         


<210>  2
<211>  2187
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MBP-PTE  wild type like S5 nucleic acid sequence

<400>  2
atgaaaatcg aagaaggtaa actggtaatc tggattaacg gcgataaagg ctataacggt       60

ctcgctgaag tcggtaagaa attcgagaaa gataccggaa ttaaagtcac cgttgagcat      120

ccggataaac tggaagagaa attcccacag gttgcggcaa ctggcgatgg ccctgacatt      180

atcttctggg cacacgaccg ctttggtggc tacgctcaat ctggcctgtt ggctgaaatc      240

accccggaca aagcgttcca ggacaagctg tatccgttta cctgggatgc cgtacgttac      300

aacggcaagc tgattgctta cccgatcgct gttgaagcgt tatcgctgat ttataacaaa      360

gatctgctgc cgaacccgcc aaaaacctgg gaagagatcc cggcgctgga taaagaactg      420

aaagcgaaag gtaagagcgc gctgatgttc aacctgcaag aaccgtactt cacctggccg      480

ctgattgctg ctgacggggg ttatgcgttc aagtatgaaa acggcaagta cgacattaaa      540

gacgtgggcg tggataacgc tggcgcgaaa gcgggtctga ccttcctggt tgacctgatt      600

aaaaacaaac acatgaatgc agacaccgat tactccatcg cagaagctgc ctttaataaa      660

ggcgaaacag cgatgaccat caacggcccg tgggcatggt ccaacatcga caccagcaaa      720

gtgaattatg gtgtaacggt actgccgacc ttcaagggtc aaccatccaa accgttcgtt      780

ggcgtgctga gcgcaggtat taacgccgcc agtccgaaca aagagctggc aaaagagttc      840

ctcgaaaact atctgctgac tgatgaaggt ctggaagcgg ttaataaaga caaaccgctg      900

ggtgccgtag cgctgaagtc ttacgaggaa gagttggcga aagatccacg tattgccgcc      960

actatggaaa acgcccagaa aggtgaaatc atgccgaaca tcccgcagat gtccgctttc     1020

tggtatgccg tgcgtactgc ggtgatcaac gccgccagcg gtcgtcagac tgtcgatgaa     1080

gccctgaaag acgcgcagac taattcgagc tcgaacaaca acaacaataa caataacaac     1140

aacctcggga tcgagggaag gatttcagaa ttcatcacca acagcggcga tcggatcaat     1200

accgtgcgcg gtcctatcac aatctctgaa gcgggtttca cactgactca cgagcacatc     1260

tgcggcagct cggcaggatt cttgcgtgct tggccggagt tcttcggtag ccgcaaagcc     1320

ctagcggaaa aggctgtgag aggattgcgc cgcgccagag cggctggcgt gcgaacgatt     1380

gtcgatgtgt cgactttcga tatcggtcgc gatgtcagtt tattggccga ggtttcgcgg     1440

gctgccgacg ttcatatcgt ggcggcgacc ggcttgtggt tcgacccgcc actttcgatg     1500

cgattgagga gtgtagagga actcacacag ttcttcctgc gtgagattca atatggcatc     1560

gaagacaccg gaattagggc gggcattatc aaggtcgcga ccacaggcaa ggcgaccccc     1620

tttcaggagt tagtgttaag ggcggccgcc cgggccagct tggccaccgg tgttccggta     1680

accactcaca cggcagcaag tcagcgcggt ggtgagcagc aggccgccat ttttgagtcc     1740

gaaggcttga gcccctcacg ggtttgtatt ggtcacagcg atgatactga cgatttgagc     1800

tatctcaccg ccctcgctgc gcgcggatac ctcatcggtc tagaccacat cccgcacagt     1860

gcgattggtc tagaagataa tgcgagtgca tcagccctcc tgggcatccg ttcgtggcaa     1920

acacgggctc tcttgatcaa ggcgctcatc gaccaaggct acatgaaaca aatcctcgtt     1980

tcgaatgact ggctgttcgg gttttcgagc tatgtcacca acatcatgga cgtgatggat     2040

agcgtgaacc ccgacgggat ggccttcatt ccactgagag tgatcccatt cctacgagag     2100

aagggcgtcc cacaggaaac gctggcaggc atcactgtga ctaacccggc gcggttcttg     2160

tcaccgacct tgcgggcgtc atgataa                                         2187


<210>  3
<211>  336
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PTE  wild type like S5 amino acid sequence

<400>  3

Ile Thr Asn Ser Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr 
1               5                   10                  15      


Ile Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          


Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Lys 
        35                  40                  45              


Ala Leu Ala Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala 
    50                  55                  60                  


Gly Val Arg Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp 
65                  70                  75                  80  


Val Ser Leu Leu Ala Glu Val Ser Arg Ala Ala Asp Val His Ile Val 
                85                  90                  95      


Ala Ala Thr Gly Leu Trp Phe Asp Pro Pro Leu Ser Met Arg Leu Arg 
            100                 105                 110         


Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly 
        115                 120                 125             


Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Thr 
    130                 135                 140                 


Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg 
145                 150                 155                 160 


Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Ala Ala Ser 
                165                 170                 175     


Gln Arg Gly Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         


Ser Pro Ser Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu 
        195                 200                 205             


Ser Tyr Leu Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp 
    210                 215                 220                 


His Ile Pro His Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser 
225                 230                 235                 240 


Ala Leu Leu Gly Ile Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     


Ala Leu Ile Asp Gln Gly Tyr Met Lys Gln Ile Leu Val Ser Asn Asp 
            260                 265                 270         


Trp Leu Phe Gly Phe Ser Ser Tyr Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             


Asp Ser Val Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile 
    290                 295                 300                 


Pro Phe Leu Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Gly Ile 
305                 310                 315                 320 


Thr Val Thr Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330                 335     


<210>  4
<211>  1017
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PTE  wild type like S5 nucleic acid sequence

<400>  4
atgatcacca acagcggcga tcggatcaat accgtgcgcg gtcctatcac aatctctgaa       60

gcgggtttca cactgactca cgagcacatc tgcggcagct cggcaggatt cttgcgtgct      120

tggccggagt tcttcggtag ccgcaaagcc ctagcggaaa aggctgtgag aggattgcgc      180

cgcgccagag cggctggcgt gcgaacgatt gtcgatgtgt cgactttcga tatcggtcgc      240

gatgtcagtt tattggccga ggtttcgcgg gctgccgacg ttcatatcgt ggcggcgacc      300

ggcttgtggt tcgacccgcc actttcgatg cgattgagga gtgtagagga actcacacag      360

ttcttcctgc gtgagattca atatggcatc gaagacaccg gaattagggc gggcattatc      420

aaggtcgcga ccacaggcaa ggcgaccccc tttcaggagt tagtgttaag ggcggccgcc      480

cgggccagct tggccaccgg tgttccggta accactcaca cggcagcaag tcagcgcggt      540

ggtgagcagc aggccgccat ttttgagtcc gaaggcttga gcccctcacg ggtttgtatt      600

ggtcacagcg atgatactga cgatttgagc tatctcaccg ccctcgctgc gcgcggatac      660

ctcatcggtc tagaccacat cccgcacagt gcgattggtc tagaagataa tgcgagtgca      720

tcagccctcc tgggcatccg ttcgtggcaa acacgggctc tcttgatcaa ggcgctcatc      780

gaccaaggct acatgaaaca aatcctcgtt tcgaatgact ggctgttcgg gttttcgagc      840

tatgtcacca acatcatgga cgtgatggat agcgtgaacc ccgacgggat ggccttcatt      900

ccactgagag tgatcccatt cctacgagag aagggcgtcc cacaggaaac gctggcaggc      960

atcactgtga ctaacccggc gcggttcttg tcaccgacct tgcgggcgtc atgataa        1017


<210>  5
<211>  726
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MBP-IVA1-m2p0  amino acid sequence

<400>  5

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365             


Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly Ile 
    370                 375                 380                 


Glu Gly Arg Ile Ser Glu Phe Ile Thr Asn Ser Gly Asp Arg Ile Asn 
385                 390                 395                 400 


Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala Gly Phe Thr Leu Thr 
                405                 410                 415     


His Glu His Ile Met Gly Ser Ser Ala Gly Phe Leu Arg Ala Trp Pro 
            420                 425                 430         


Glu Phe Phe Gly Ser Arg Ala Ala Leu Val Glu Lys Ala Val Arg Gly 
        435                 440                 445             


Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr Ile Val Asp Val Ser 
    450                 455                 460                 


Thr Phe Asp Ala Gly Arg Asp Val Ser Leu Leu Ala Glu Val Ser Glu 
465                 470                 475                 480 


Ala Ala Asp Val His Ile Val Ala Ala Thr Gly Leu Trp Glu Asp Pro 
                485                 490                 495     


Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu Leu Thr Gln Phe Phe 
            500                 505                 510         


Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr Gly Ile Arg Ala Gly 
        515                 520                 525             


Ile Ile Lys Val Ala Thr Asn Gly Lys Ala Thr Pro Phe Gln Glu Leu 
    530                 535                 540                 


Val Leu Arg Ala Ala Ala Arg Ala Ser Leu Ala Thr Gly Val Pro Val 
545                 550                 555                 560 


Thr Thr His Thr Asp Ala Ser Gln Arg Asp Gly Glu Gln Gln Ala Ala 
                565                 570                 575     


Ile Phe Glu Ser Glu Gly Leu Asp Pro Ser Arg Val Cys Ile Gly His 
            580                 585                 590         


Ser Asp Gly Thr Asp Asp Leu Asp Tyr Leu Thr Ala Leu Ala Ala Arg 
        595                 600                 605             


Gly Tyr Leu Ile Gly Leu Asp Gly Ile Pro His Ser Ala Ile Gly Leu 
    610                 615                 620                 


Glu Asp Asn Ser Ala Ser Ala Leu Leu Gly Asn Arg Ser Trp Gln Thr 
625                 630                 635                 640 


Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp Gln Gly Tyr Val Lys Gln 
                645                 650                 655     


Ile Leu Val Ser Asn Asp Trp Leu Phe Gly Phe Ser Ser Trp Val Thr 
            660                 665                 670         


Asn Ile Met Asp Val Met Asp Ser Val Asn Pro Asp Gly Met Ala Phe 
        675                 680                 685             


Ile Pro Leu Arg Val Ile Pro Phe Leu Arg Glu Lys Gly Val Pro Gln 
    690                 695                 700                 


Glu Thr Leu Ala Thr Ile Thr Val Glu Asn Pro Ala Arg Phe Leu Ser 
705                 710                 715                 720 


Pro Thr Leu Arg Ala Ser 
                725     


<210>  6
<211>  2184
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MBP-IVA1-m2p0  nucleic acid sequence

<400>  6
atgaaaatcg aagaaggtaa actggtaatc tggattaacg gcgataaagg ctataacggt       60

ctcgctgaag tcggtaagaa attcgagaaa gataccggaa ttaaagtcac cgttgagcat      120

ccggataaac tggaagagaa attcccacag gttgcggcaa ctggcgatgg ccctgacatt      180

atcttctggg cacacgaccg ctttggtggc tacgctcaat ctggcctgtt ggctgaaatc      240

accccggaca aagcgttcca ggacaagctg tatccgttta cctgggatgc cgtacgttac      300

aacggcaagc tgattgctta cccgatcgct gttgaagcgt tatcgctgat ttataacaaa      360

gatctgctgc cgaacccgcc aaaaacctgg gaagagatcc cggcgctgga taaagaactg      420

aaagcgaaag gtaagagcgc gctgatgttc aacctgcaag aaccgtactt cacctggccg      480

ctgattgctg ctgacggggg ttatgcgttc aagtatgaaa acggcaagta cgacattaaa      540

gacgtgggcg tggataacgc tggcgcgaaa gcgggtctga ccttcctggt tgacctgatt      600

aaaaacaaac acatgaatgc agacaccgat tactccatcg cagaagctgc ctttaataaa      660

ggcgaaacag cgatgaccat caacggcccg tgggcatggt ccaacatcga caccagcaaa      720

gtgaattatg gtgtaacggt actgccgacc ttcaagggtc aaccatccaa accgttcgtt      780

ggcgtgctga gcgcaggtat taacgccgcc agtccgaaca aagagctggc aaaagagttc      840

ctcgaaaact atctgctgac tgatgaaggt ctggaagcgg ttaataaaga caaaccgctg      900

ggtgccgtag cgctgaagtc ttacgaggaa gagttggcga aagatccacg tattgccgcc      960

actatggaaa acgcccagaa aggtgaaatc atgccgaaca tcccgcagat gtccgctttc     1020

tggtatgccg tgcgtactgc ggtgatcaac gccgccagcg gtcgtcagac tgtcgatgaa     1080

gccctgaaag acgcgcagac taattcgagc tcgaacaaca acaacaataa caataacaac     1140

aacctcggga tcgagggaag gatttcagaa ttcatcacca acagcggcga ccgtatcaac     1200

accgtccgtg gtccgatcac catctctgag gcgggcttca ccctgactca cgaacacatt     1260

atgggttcta gcgcaggttt tctgcgcgct tggccggagt ttttcggttc tcgtgctgct     1320

ctggtggaaa aagcggttcg tggcctgcgt cgtgcgcgtg cggctggtgt gcgtaccatc     1380

gttgacgttt ctaccttcga cgccggtcgt gatgtttctc tgctggccga ggtttctgaa     1440

gcggccgatg ttcacattgt tgcagcgact ggtctgtggg aagatccgcc gctgtctatg     1500

cgtctgcgct ctgttgaaga actcacccag ttctttctcc gtgaaatcca gtacggcatc     1560

gaggacacgg gtatccgtgc cggtatcatt aaagttgcca ccaacggtaa agcgaccccg     1620

tttcaggaac tggttctgcg tgcagcagct cgtgcctccc tcgccaccgg cgttccggtc     1680

accacccaca ccgacgcttc tcagcgtgac ggtgaacagc aggcggcgat cttcgaaagc     1740

gaaggtctgg acccgtctcg tgtttgtatc ggtcactctg acggcaccga tgatctggac     1800

tacctgaccg cgctcgcggc tcgtggttac ctgattggcc tggatggtat tccgcactct     1860

gcgatcggcc tcgaagacaa ctctgcgtcc gctctgctcg gtaatcgctc ttggcagacc     1920

cgtgcgctgc tgatcaaagc gctgatcgac cagggctacg ttaaacagat cctggtttct     1980

aacgattggc tgttcggttt ttcttcttgg gttaccaaca tcatggacgt tatggactct     2040

gttaacccag acggtatggc gttcatcccg ctgcgtgtta tcccgttcct gcgcgagaaa     2100

ggtgttccac aagagacgct ggcgaccatc accgttgaaa accctgctcg tttcctgtct     2160

ccaaccctcc gtgcttcttg ataa                                            2184


<210>  7
<211>  727
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MBP-1-3-D5  amino acid sequence

<400>  7

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365             


Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly Ile 
    370                 375                 380                 


Glu Gly Arg Ile Ser Glu Phe Ile Thr Asn Ser Gly Asp Arg Ile Asn 
385                 390                 395                 400 


Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala Gly Phe Thr Leu Thr 
                405                 410                 415     


His Glu His Ile Cys Gly Ser Ser Ala Gly Phe Leu Arg Ala Trp Pro 
            420                 425                 430         


Glu Phe Phe Gly Ser Arg Ala Ala Leu Val Glu Lys Ala Val Arg Gly 
        435                 440                 445             


Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr Ile Val Asp Val Ser 
    450                 455                 460                 


Thr Phe Asp Ile Gly Arg Asp Val Ser Leu Leu Ala Glu Val Ser Glu 
465                 470                 475                 480 


Ala Ala Asp Val His Ile Val Ala Ala Thr Gly Leu Trp Glu Asp Pro 
                485                 490                 495     


Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu Leu Thr Gln Phe Phe 
            500                 505                 510         


Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr Gly Ile Arg Ala Gly 
        515                 520                 525             


Ile Ile Lys Val Ala Thr Asn Gly Lys Ala Thr Pro Phe Gln Glu Leu 
    530                 535                 540                 


Val Leu Arg Ala Ala Ala Arg Ala Ser Leu Ala Thr Gly Val Pro Val 
545                 550                 555                 560 


Thr Thr His Thr Asp Ala Ser Gln Arg Asp Gly Glu Gln Gln Ala Ala 
                565                 570                 575     


Ile Phe Glu Ser Glu Gly Leu Asp Pro Ser Arg Val Cys Ile Gly His 
            580                 585                 590         


Ser Asp Gly Thr Asp Asp Leu Asp Tyr Leu Thr Ala Leu Ala Ala Arg 
        595                 600                 605             


Gly Tyr Leu Ile Gly Leu Asp Gly Ile Pro His Ser Ala Ile Gly Leu 
    610                 615                 620                 


Glu Asp Asn Ala Ser Ala Ser Ala Leu Leu Gly Asn Arg Ser Trp Gln 
625                 630                 635                 640 


Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp Gln Gly Tyr Val Lys 
                645                 650                 655     


Gln Ile Leu Val Ser Asn Asp Trp Leu Phe Gly Phe Ser Ser Trp Val 
            660                 665                 670         


Thr Asn Ile Met Asp Val Met Asp Ser Val Asn Pro Asp Gly Met Ala 
        675                 680                 685             


Phe Ile Pro Leu Arg Val Ile Pro Phe Leu Arg Glu Lys Gly Val Pro 
    690                 695                 700                 


Gln Glu Thr Leu Ala Thr Ile Thr Val Glu Asn Pro Ala Arg Phe Leu 
705                 710                 715                 720 


Ser Pro Thr Leu Arg Ala Ser 
                725         


<210>  8
<211>  2187
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MBP-1-3-D5  nucleic acid sequence

<400>  8
atgaaaatcg aagaaggtaa actggtaatc tggattaacg gcgataaagg ctataacggt       60

ctcgctgaag tcggtaagaa attcgagaaa gataccggaa ttaaagtcac cgttgagcat      120

ccggataaac tggaagagaa attcccacag gttgcggcaa ctggcgatgg ccctgacatt      180

atcttctggg cacacgaccg ctttggtggc tacgctcaat ctggcctgtt ggctgaaatc      240

accccggaca aagcgttcca ggacaagctg tatccgttta cctgggatgc cgtacgttac      300

aacggcaagc tgattgctta cccgatcgct gttgaagcgt tatcgctgat ttataacaaa      360

gatctgctgc cgaacccgcc aaaaacctgg gaagagatcc cggcgctgga taaagaactg      420

aaagcgaaag gtaagagcgc gctgatgttc aacctgcaag aaccgtactt cacctggccg      480

ctgattgctg ctgacggggg ttatgcgttc aagtatgaaa acggcaagta cgacattaaa      540

gacgtgggcg tggataacgc tggcgcgaaa gcgggtctga ccttcctggt tgacctgatt      600

aaaaacaaac acatgaatgc agacaccgat tactccatcg cagaagctgc ctttaataaa      660

ggcgaaacag cgatgaccat caacggcccg tgggcatggt ccaacatcga caccagcaaa      720

gtgaattatg gtgtaacggt actgccgacc ttcaagggtc aaccatccaa accgttcgtt      780

ggcgtgctga gcgcaggtat taacgccgcc agtccgaaca aagagctggc aaaagagttc      840

ctcgaaaact atctgctgac tgatgaaggt ctggaagcgg ttaataaaga caaaccgctg      900

ggtgccgtag cgctgaagtc ttacgaggaa gagttggcga aagatccacg tattgccgcc      960

accatggaaa acgcccagaa aggtgaaatc atgccgaaca tcccgcagat gtccgctttc     1020

tggtatgccg tgcgtactgc ggtgatcaac gccgccagcg gtcgtcagac tgtcgatgaa     1080

gccctgaaag acgcgcagac taattcgagc tcgaacaaca acaacaataa caataacaac     1140

aacctcggga tcgagggaag gatttcagaa ttcatcacca acagcggcga ccgtatcaac     1200

accgtccgtg gtccgatcac catctctgag gcgggcttca ccctgactca cgaacacatt     1260

tgcggttcta gcgcaggttt tctgcgcgct tggccggagt ttttcggttc tcgtgctgct     1320

ctggtggaaa aagcggttcg tggcctgcgt cgtgcgcgtg cggctggtgt gcgtaccatc     1380

gttgacgttt ctaccttcga cattggtcgt gatgtttctc tgctggccga ggtttctgaa     1440

gcggccgatg ttcacattgt tgcagcgact ggtctgtggg aagatccgcc gctgtctatg     1500

cgtctgcgct ctgttgaaga actcacccag ttctttctcc gtgaaatcca gtacggcatc     1560

gaggacacgg gtatccgtgc cggtatcatt aaagttgcca ccaacggtaa agcgaccccg     1620

tttcaggaac tggttctgcg tgcagcagct cgtgcctccc tcgccaccgg cgttccggtc     1680

accacccaca ccgacgcttc tcagcgtgac ggtgaacagc aggcggcgat cttcgaaagc     1740

gaaggtctgg acccgtctcg tgtttgtatc ggtcactctg acggcaccga tgatctggac     1800

tacctgaccg cgctcgcggc tcgtggttac ctgattggcc tggatggtat tccgcactct     1860

gcgatcggcc tcgaagacaa cgcatctgcg tccgctctgc tcggtaatcg ctcttggcag     1920

acccgtgcgc tgctgatcaa agcgctgatc gaccagggct acgttaaaca gatcctggtt     1980

tctaacgatt ggctgttcgg tttttcttct tgggttacca acatcatgga cgttatggac     2040

tctgttaacc cagacggtat ggcgttcatc ccgctgcgtg ttatcccgtt cctgcgcgag     2100

aaaggtgttc cacaagagac gctggcgacc atcaccgttg aaaaccctgc tcgtttcctg     2160

tctccaaccc tccgtgcttc ttgataa                                         2187


<210>  9
<211>  727
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MBP-10-2-C3 amino acid sequence

<400>  9

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365             


Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly Ile 
    370                 375                 380                 


Glu Gly Arg Ile Ser Glu Phe Ile Thr Asn Ser Gly Asp Arg Ile Asn 
385                 390                 395                 400 


Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala Gly Phe Thr Leu Thr 
                405                 410                 415     


His Glu His Ile Cys Gly Ser Ser Ala Gly Phe Leu Arg Ala Trp Pro 
            420                 425                 430         


Glu Phe Phe Gly Ser Arg Ala Ala Leu Met Glu Lys Ala Val Arg Gly 
        435                 440                 445             


Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr Ile Val Asp Val Ser 
    450                 455                 460                 


Thr Phe Asp Ile Gly Arg Asp Val Ser Leu Leu Ala Glu Val Ser Glu 
465                 470                 475                 480 


Ala Ala Asp Val His Ile Val Ala Ala Thr Gly Leu Trp Glu Asp Pro 
                485                 490                 495     


Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu Leu Thr Gln Phe Phe 
            500                 505                 510         


Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr Gly Ile Arg Ala Gly 
        515                 520                 525             


Ile Ile Lys Val Ala Thr Asn Gly Lys Ala Thr Pro Phe Gln Glu Leu 
    530                 535                 540                 


Val Leu Arg Ala Ala Ala Arg Ala Ser Leu Ala Thr Gly Val Pro Val 
545                 550                 555                 560 


Thr Thr His Thr Asp Ala Ser Gln Arg Asp Gly Glu Gln Gln Ala Ala 
                565                 570                 575     


Ile Phe Glu Ser Glu Gly Leu Asp Pro Ser Arg Val Cys Ile Gly His 
            580                 585                 590         


Ser Asp Gly Thr Asp Asp Leu Asp Tyr Leu Thr Ala Leu Ala Ala Arg 
        595                 600                 605             


Gly Tyr Leu Ile Gly Leu Asp Gly Ile Pro His Ser Ala Ile Gly Leu 
    610                 615                 620                 


Glu Asp Asn Ala Ser Ala Ser Ser Trp Leu Gly Asn Arg Ser Trp Gln 
625                 630                 635                 640 


Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp Gln Gly Tyr Val Lys 
                645                 650                 655     


Gln Ile Leu Val Ser Asn Asp Trp Leu Phe Gly Phe Ser Ser Trp Val 
            660                 665                 670         


Thr Asn Ile Met Asp Val Met Asp Ser Val Asn Pro Asp Gly Met Ala 
        675                 680                 685             


Phe Ile Pro Leu Arg Val Ile Pro Phe Leu Arg Glu Lys Gly Val Pro 
    690                 695                 700                 


Gln Glu Thr Leu Ala Thr Ile Thr Val Glu Asn Pro Ala Arg Phe Leu 
705                 710                 715                 720 


Ser Pro Thr Leu Arg Ala Ser 
                725         


<210>  10
<211>  2187
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MBP-10-2-C3 nucleic acid sequence

<400>  10
atgaaaatcg aagaaggtaa actggtaatc tggattaacg gcgataaagg ctataacggt       60

ctcgctgaag tcggtaagaa attcgagaaa gataccggaa ttaaagtcac cgttgagcat      120

ccggataaac tggaagagaa attcccacag gttgcggcaa ctggcgatgg ccctgacatt      180

atcttctggg cacacgaccg ctttggtggc tacgctcaat ctggcctgtt ggctgaaatc      240

accccggaca aagcgttcca ggacaagctg tatccgttta cctgggatgc cgtacgttac      300

aacggcaagc tgattgctta cccgatcgct gttgaagcgt tatcgctgat ttataacaaa      360

gatctgctgc cgaacccgcc aaaaacctgg gaagagatcc cggcgctgga taaagaactg      420

aaagcgaaag gtaagagcgc gctgatgttc aacctgcaag aaccgtactt cacctggccg      480

ctgattgctg ctgacggggg ttatgcgttc aagtatgaaa acggcaagta cgacattaaa      540

gacgtgggcg tggataacgc tggcgcgaaa gcgggtctga ccttcctggt tgacctgatt      600

aaaaacaaac acatgaatgc agacaccgat tactccatcg cagaagctgc ctttaataaa      660

ggcgaaacag cgatgaccat caacggcccg tgggcatggt ccaacatcga caccagcaaa      720

gtgaattatg gtgtaacggt actgccgacc ttcaagggtc aaccatccaa accgttcgtt      780

ggcgtgctga gcgcaggtat taacgccgcc agtccgaaca aagagctggc aaaagagttc      840

ctcgaaaact atctgctgac tgatgaaggt ctggaagcgg ttaataaaga caaaccgctg      900

ggtgccgtag cgctgaagtc ttacgaggaa gagttggcga aagatccacg tattgccgcc      960

accatggaaa acgcccagaa aggtgaaatc atgccgaaca tcccgcagat gtccgctttc     1020

tggtatgccg tgcgtactgc ggtgatcaac gccgccagcg gtcgtcagac tgtcgatgaa     1080

gccctgaaag acgcgcagac taattcgagc tcgaacaaca acaacaataa caataacaac     1140

aacctcggga tcgagggaag gatttcagaa ttcatcacca acagcggcga ccgtatcaac     1200

accgtccgtg gtccgatcac catctctgag gcgggcttca ccctgactca cgaacacatt     1260

tgcggttcta gcgcaggttt tctgcgcgct tggccggagt ttttcggttc tcgtgctgct     1320

ctgatggaaa aagcggttcg tggcctgcgt cgtgcgcgtg cggctggtgt gcgtaccatc     1380

gttgacgttt ctaccttcga cattggtcgt gatgtttctc tgctggccga ggtttctgaa     1440

gcggccgatg ttcacattgt tgcagcgact ggtctgtggg aagatccgcc gctgtctatg     1500

cgtctgcgct ctgttgaaga actcacccag ttctttctcc gtgaaatcca gtacggcatc     1560

gaggacacgg gtatccgtgc cggtatcatt aaagttgcca ccaacggtaa agcgaccccg     1620

tttcaggaac tggttctgcg tgcagcagct cgtgcctccc tcgccaccgg cgttccggtc     1680

accacccaca ccgacgcttc tcagcgtgac ggtgaacagc aggcggcgat cttcgaaagc     1740

gaaggtctgg acccgtctcg tgtttgtatc ggtcactctg acggcaccga tgatctggac     1800

tacctgaccg cgctcgcggc tcgtggttac ctgattggcc tggatggtat tccgcactct     1860

gcgatcggcc tcgaagacaa cgcatctgcg tcctcctggc tcggtaatcg ctcttggcag     1920

acccgtgcgc tgctgatcaa agcgctgatc gaccagggct acgttaaaca gatcctggtt     1980

tctaacgatt ggctgttcgg tttttcttct tgggttacca acatcatgga cgttatggac     2040

tctgttaacc cagacggtat ggcgttcatc ccgctgcgtg ttatcccgtt cctgcgcgag     2100

aaaggtgttc cacaagagac gctggcgacc atcaccgttg aaaaccctgc tcgtttcctg     2160

tctccaaccc tccgtgcttc ttgataa                                         2187


<210>  11
<211>  727
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MBP-10-1-D11 amino acid sequence

<400>  11

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365             


Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly Ile 
    370                 375                 380                 


Glu Gly Arg Ile Ser Glu Phe Ile Thr Asn Ser Gly Asp Arg Ile Asn 
385                 390                 395                 400 


Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala Gly Phe Thr Leu Thr 
                405                 410                 415     


His Glu His Ile Cys Gly Ser Ser Ala Gly Phe Leu Arg Ala Trp Pro 
            420                 425                 430         


Glu Phe Phe Gly Ser Arg Ala Ala Leu Met Glu Lys Ala Val Arg Gly 
        435                 440                 445             


Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr Ile Val Asp Val Ser 
    450                 455                 460                 


Thr Phe Asp Ile Gly Arg Asp Val Ser Leu Leu Ala Glu Val Ser Glu 
465                 470                 475                 480 


Ala Ala Asp Val His Ile Val Ala Ala Thr Gly Leu Trp Glu Asp Pro 
                485                 490                 495     


Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu Leu Thr Gln Phe Phe 
            500                 505                 510         


Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr Gly Ile Arg Ala Gly 
        515                 520                 525             


Ile Ile Lys Val Ala Thr Asn Gly Lys Ala Thr Pro Phe Gln Glu Leu 
    530                 535                 540                 


Val Leu Arg Ala Ala Ala Arg Ala Ser Leu Ala Thr Gly Val Pro Val 
545                 550                 555                 560 


Thr Thr His Thr Asp Ala Ser Gln Arg Asp Gly Glu Gln Gln Ala Ala 
                565                 570                 575     


Ile Phe Glu Ser Glu Gly Leu Asp Pro Ser Arg Val Cys Ile Gly His 
            580                 585                 590         


Ser Asp Gly Thr Asp Asp Leu Asp Tyr Leu Thr Ala Leu Ala Ala Arg 
        595                 600                 605             


Gly Tyr Leu Ile Gly Leu Asp Gly Ile Pro His Ser Ala Ile Gly Leu 
    610                 615                 620                 


Glu Asp Asn Ala Met Ala Ser Ser Trp Leu Gly Asn Arg Ser Trp Gln 
625                 630                 635                 640 


Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp Gln Gly Tyr Val Lys 
                645                 650                 655     


Gln Ile Leu Val Ser Asn Asp Trp Leu Phe Gly Phe Ser Ser Trp Val 
            660                 665                 670         


Thr Asn Ile Met Asp Val Met Asp Ser Val Asn Pro Asp Gly Met Ala 
        675                 680                 685             


Phe Ile Pro Leu Arg Val Ile Pro Phe Leu Arg Glu Lys Gly Val Pro 
    690                 695                 700                 


Gln Glu Thr Leu Ala Thr Ile Thr Val Glu Asn Pro Ala Arg Phe Leu 
705                 710                 715                 720 


Ser Pro Thr Leu Arg Ala Ser 
                725         


<210>  12
<211>  2187
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MBP-10-1-D11 nucleic acid sequence

<400>  12
atgaaaatcg aagaaggtaa actggtaatc tggattaacg gcgataaagg ctataacggt       60

ctcgctgaag tcggtaagaa attcgagaaa gataccggaa ttaaagtcac cgttgagcat      120

ccggataaac tggaagagaa attcccacag gttgcggcaa ctggcgatgg ccctgacatt      180

atcttctggg cacacgaccg ctttggtggc tacgctcaat ctggcctgtt ggctgaaatc      240

accccggaca aagcgttcca ggacaagctg tatccgttta cctgggatgc cgtacgttac      300

aacggcaagc tgattgctta cccgatcgct gttgaagcgt tatcgctgat ttataacaaa      360

gatctgctgc cgaacccgcc aaaaacctgg gaagagatcc cggcgctgga taaagaactg      420

aaagcgaaag gtaagagcgc gctgatgttc aacctgcaag aaccgtactt cacctggccg      480

ctgattgctg ctgacggggg ttatgcgttc aagtatgaaa acggcaagta cgacattaaa      540

gacgtgggcg tggataacgc tggcgcgaaa gcgggtctga ccttcctggt tgacctgatt      600

aaaaacaaac acatgaatgc agacaccgat tactccatcg cagaagctgc ctttaataaa      660

ggcgaaacag cgatgaccat caacggcccg tgggcatggt ccaacatcga caccagcaaa      720

gtgaattatg gtgtaacggt actgccgacc ttcaagggtc aaccatccaa accgttcgtt      780

ggcgtgctga gcgcaggtat taacgccgcc agtccgaaca aagagctggc aaaagagttc      840

ctcgaaaact atctgctgac tgatgaaggt ctggaagcgg ttaataaaga caaaccgctg      900

ggtgccgtag cgctgaagtc ttacgaggaa gagttggcga aagatccacg tattgccgcc      960

accatggaaa acgcccagaa aggtgaaatc atgccgaaca tcccgcagat gtccgctttc     1020

tggtatgccg tgcgtactgc ggtgatcaac gccgccagcg gtcgtcagac tgtcgatgaa     1080

gccctgaaag acgcgcagac taattcgagc tcgaacaaca acaacaataa caataacaac     1140

aacctcggga tcgagggaag gatttcagaa ttcatcacca acagcggcga ccgtatcaac     1200

accgtccgtg gtccgatcac catctctgag gcgggcttca ccctgactca cgaacacatt     1260

tgcggttcta gcgcaggttt tctgcgcgct tggccggagt ttttcggttc tcgtgctgct     1320

ctgatggaaa aagcggttcg tggcctgcgt cgtgcgcgtg cggctggtgt gcgtaccatc     1380

gttgacgttt ctaccttcga cattggtcgt gatgtttctc tgctggccga ggtttctgaa     1440

gcggccgatg ttcacattgt tgcagcgact ggtctgtggg aagatccgcc gctgtctatg     1500

cgtctgcgct ctgttgaaga actcacccag ttctttctcc gtgaaatcca gtacggcatc     1560

gaggacacgg gtatccgtgc cggtatcatt aaagttgcca ccaacggtaa agcgaccccg     1620

tttcaggaac tggttctgcg tgcagcagct cgtgcctccc tcgccaccgg cgttccggtc     1680

accacccaca ccgacgcttc tcagcgtgac ggtgaacagc aggcggcgat cttcgaaagc     1740

gaaggtctgg acccgtctcg tgtttgtatc ggtcactctg acggcaccga tgatctggac     1800

tacctgaccg cgctcgcggc tcgtggttac ctgattggcc tggatggtat tccgcactct     1860

gcgatcggcc tcgaagacaa cgcaatggcg tcctcttggc tcggtaatcg ctcttggcag     1920

acccgtgcgc tgctgatcaa agcgctgatc gaccagggct acgttaaaca gatcctggtt     1980

tctaacgatt ggctgttcgg tttttcttct tgggttacca acatcatgga cgttatggac     2040

tctgttaacc cagacggtat ggcgttcatc ccgctgcgtg ttatcccgtt cctgcgcgag     2100

aaaggtgttc cacaagagac gctggcgacc atcaccgttg aaaaccctgc tcgtttcctg     2160

tctccaaccc tccgtgcttc ttgataa                                         2187


<210>  13
<211>  727
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MBP-10-1-D11-I106A amino acid sequence

<400>  13

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365             


Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly Ile 
    370                 375                 380                 


Glu Gly Arg Ile Ser Glu Phe Ile Thr Asn Ser Gly Asp Arg Ile Asn 
385                 390                 395                 400 


Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala Gly Phe Thr Leu Thr 
                405                 410                 415     


His Glu His Ile Cys Gly Ser Ser Ala Gly Phe Leu Arg Ala Trp Pro 
            420                 425                 430         


Glu Phe Phe Gly Ser Arg Ala Ala Leu Met Glu Lys Ala Val Arg Gly 
        435                 440                 445             


Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr Ile Val Asp Val Ser 
    450                 455                 460                 


Thr Phe Asp Ala Gly Arg Asp Val Ser Leu Leu Ala Glu Val Ser Glu 
465                 470                 475                 480 


Ala Ala Asp Val His Ile Val Ala Ala Thr Gly Leu Trp Glu Asp Pro 
                485                 490                 495     


Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu Leu Thr Gln Phe Phe 
            500                 505                 510         


Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr Gly Ile Arg Ala Gly 
        515                 520                 525             


Ile Ile Lys Val Ala Thr Asn Gly Lys Ala Thr Pro Phe Gln Glu Leu 
    530                 535                 540                 


Val Leu Arg Ala Ala Ala Arg Ala Ser Leu Ala Thr Gly Val Pro Val 
545                 550                 555                 560 


Thr Thr His Thr Asp Ala Ser Gln Arg Asp Gly Glu Gln Gln Ala Ala 
                565                 570                 575     


Ile Phe Glu Ser Glu Gly Leu Asp Pro Ser Arg Val Cys Ile Gly His 
            580                 585                 590         


Ser Asp Gly Thr Asp Asp Leu Asp Tyr Leu Thr Ala Leu Ala Ala Arg 
        595                 600                 605             


Gly Tyr Leu Ile Gly Leu Asp Gly Ile Pro His Ser Ala Ile Gly Leu 
    610                 615                 620                 


Glu Asp Asn Ala Met Ala Ser Ser Trp Leu Gly Asn Arg Ser Trp Gln 
625                 630                 635                 640 


Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp Gln Gly Tyr Val Lys 
                645                 650                 655     


Gln Ile Leu Val Ser Asn Asp Trp Leu Phe Gly Phe Ser Ser Trp Val 
            660                 665                 670         


Thr Asn Ile Met Asp Val Met Asp Ser Val Asn Pro Asp Gly Met Ala 
        675                 680                 685             


Phe Ile Pro Leu Arg Val Ile Pro Phe Leu Arg Glu Lys Gly Val Pro 
    690                 695                 700                 


Gln Glu Thr Leu Ala Thr Ile Thr Val Glu Asn Pro Ala Arg Phe Leu 
705                 710                 715                 720 


Ser Pro Thr Leu Arg Ala Ser 
                725         


<210>  14
<211>  2187
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MBP-10-1-D11I106A nucleic acid sequence

<400>  14
atgaaaatcg aagaaggtaa actggtaatc tggattaacg gcgataaagg ctataacggt       60

ctcgctgaag tcggtaagaa attcgagaaa gataccggaa ttaaagtcac cgttgagcat      120

ccggataaac tggaagagaa attcccacag gttgcggcaa ctggcgatgg ccctgacatt      180

atcttctggg cacacgaccg ctttggtggc tacgctcaat ctggcctgtt ggctgaaatc      240

accccggaca aagcgttcca ggacaagctg tatccgttta cctgggatgc cgtacgttac      300

aacggcaagc tgattgctta cccgatcgct gttgaagcgt tatcgctgat ttataacaaa      360

gatctgctgc cgaacccgcc aaaaacctgg gaagagatcc cggcgctgga taaagaactg      420

aaagcgaaag gtaagagcgc gctgatgttc aacctgcaag aaccgtactt cacctggccg      480

ctgattgctg ctgacggggg ttatgcgttc aagtatgaaa acggcaagta cgacattaaa      540

gacgtgggcg tggataacgc tggcgcgaaa gcgggtctga ccttcctggt tgacctgatt      600

aaaaacaaac acatgaatgc agacaccgat tactccatcg cagaagctgc ctttaataaa      660

ggcgaaacag cgatgaccat caacggcccg tgggcatggt ccaacatcga caccagcaaa      720

gtgaattatg gtgtaacggt actgccgacc ttcaagggtc aaccatccaa accgttcgtt      780

ggcgtgctga gcgcaggtat taacgccgcc agtccgaaca aagagctggc aaaagagttc      840

ctcgaaaact atctgctgac tgatgaaggt ctggaagcgg ttaataaaga caaaccgctg      900

ggtgccgtag cgctgaagtc ttacgaggaa gagttggcga aagatccacg tattgccgcc      960

accatggaaa acgcccagaa aggtgaaatc atgccgaaca tcccgcagat gtccgctttc     1020

tggtatgccg tgcgtactgc ggtgatcaac gccgccagcg gtcgtcagac tgtcgatgaa     1080

gccctgaaag acgcgcagac taattcgagc tcgaacaaca acaacaataa caataacaac     1140

aacctcggga tcgagggaag gatttcagaa ttcatcacca acagcggcga ccgtatcaac     1200

accgtccgtg gtccgatcac catctctgag gcgggcttca ccctgactca cgaacacatt     1260

tgcggttcta gcgcaggttt tctgcgcgct tggccggagt ttttcggttc tcgtgctgct     1320

ctgatggaaa aagcggttcg tggcctgcgt cgtgcgcgtg cggctggtgt gcgtaccatc     1380

gttgacgttt ctaccttcga cgccggtcgt gatgtttctc tgctggccga ggtttctgaa     1440

gcggccgatg ttcacattgt tgcagcgact ggtctgtggg aagatccgcc gctgtctatg     1500

cgtctgcgct ctgttgaaga actcacccag ttctttctcc gtgaaatcca gtacggcatc     1560

gaggacacgg gtatccgtgc cggtatcatt aaagttgcca ccaacggtaa agcgaccccg     1620

tttcaggaac tggttctgcg tgcagcagct cgtgcctccc tcgccaccgg cgttccggtc     1680

accacccaca ccgacgcttc tcagcgtgac ggtgaacagc aggcggcgat cttcgaaagc     1740

gaaggtctgg acccgtctcg tgtttgtatc ggtcactctg acggcaccga tgatctggac     1800

tacctgaccg cgctcgcggc tcgtggttac ctgattggcc tggatggtat tccgcactct     1860

gcgatcggcc tcgaagacaa cgcaatggcg tcctcctggc tcggtaatcg ctcttggcag     1920

acccgtgcgc tgctgatcaa agcgctgatc gaccagggct acgttaaaca gatcctggtt     1980

tctaacgatt ggctgttcgg tttttcttct tgggttacca acatcatgga cgttatggac     2040

tctgttaacc cagacggtat ggcgttcatc ccgctgcgtg ttatcccgtt cctgcgcgag     2100

aaaggtgttc cacaagagac gctggcgacc atcaccgttg aaaaccctgc tcgtttcctg     2160

tctccaaccc tccgtgcttc ttgataa                                         2187


<210>  15
<211>  335
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IVA1-m2p0  amino acid sequence

<400>  15

Ile Thr Asn Ser Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr 
1               5                   10                  15      


Ile Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Met Gly Ser 
            20                  25                  30          


Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala 
        35                  40                  45              


Ala Leu Val Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala 
    50                  55                  60                  


Gly Val Arg Thr Ile Val Asp Val Ser Thr Phe Asp Ala Gly Arg Asp 
65                  70                  75                  80  


Val Ser Leu Leu Ala Glu Val Ser Glu Ala Ala Asp Val His Ile Val 
                85                  90                  95      


Ala Ala Thr Gly Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg 
            100                 105                 110         


Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly 
        115                 120                 125             


Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn 
    130                 135                 140                 


Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg 
145                 150                 155                 160 


Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Asp Ala Ser 
                165                 170                 175     


Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         


Asp Pro Ser Arg Val Cys Ile Gly His Ser Asp Gly Thr Asp Asp Leu 
        195                 200                 205             


Asp Tyr Leu Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp 
    210                 215                 220                 


Gly Ile Pro His Ser Ala Ile Gly Leu Glu Asp Asn Ser Ala Ser Ala 
225                 230                 235                 240 


Leu Leu Gly Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys Ala 
                245                 250                 255     


Leu Ile Asp Gln Gly Tyr Val Lys Gln Ile Leu Val Ser Asn Asp Trp 
            260                 265                 270         


Leu Phe Gly Phe Ser Ser Trp Val Thr Asn Ile Met Asp Val Met Asp 
        275                 280                 285             


Ser Val Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile Pro 
    290                 295                 300                 


Phe Leu Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Thr Ile Thr 
305                 310                 315                 320 


Val Glu Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330                 335 


<210>  16
<211>  1014
<212>  DNA
<213>  Artificial sequence

<220>
<223>  IVA1-m2p0  nucleic acid sequence

<400>  16
atgatcacca acagcggcga ccgtatcaac accgtccgtg gtccgatcac catctctgag       60

gcgggcttca ccctgactca cgaacacatt atgggttcta gcgcaggttt tctgcgcgct      120

tggccggagt ttttcggttc tcgtgctgct ctggtggaaa aagcggttcg tggcctgcgt      180

cgtgcgcgtg cggctggtgt gcgtaccatc gttgacgttt ctaccttcga cgccggtcgt      240

gatgtttctc tgctggccga ggtttctgaa gcggccgatg ttcacattgt tgcagcgact      300

ggtctgtggg aagatccgcc gctgtctatg cgtctgcgct ctgttgaaga actcacccag      360

ttctttctcc gtgaaatcca gtacggcatc gaggacacgg gtatccgtgc cggtatcatt      420

aaagttgcca ccaacggtaa agcgaccccg tttcaggaac tggttctgcg tgcagcagct      480

cgtgcctccc tcgccaccgg cgttccggtc accacccaca ccgacgcttc tcagcgtgac      540

ggtgaacagc aggcggcgat cttcgaaagc gaaggtctgg acccgtctcg tgtttgtatc      600

ggtcactctg acggcaccga tgatctggac tacctgaccg cgctcgcggc tcgtggttac      660

ctgattggcc tggatggtat tccgcactct gcgatcggcc tcgaagacaa ctctgcgtcc      720

gctctgctcg gtaatcgctc ttggcagacc cgtgcgctgc tgatcaaagc gctgatcgac      780

cagggctacg ttaaacagat cctggtttct aacgattggc tgttcggttt ttcttcttgg      840

gttaccaaca tcatggacgt tatggactct gttaacccag acggtatggc gttcatcccg      900

ctgcgtgtta tcccgttcct gcgcgagaaa ggtgttccac aagagacgct ggcgaccatc      960

accgttgaaa accctgctcg tttcctgtct ccaaccctcc gtgcttcttg ataa           1014


<210>  17
<211>  336
<212>  PRT
<213>  Artificial sequence

<220>
<223>  1-3-D5  amino acid sequence

<400>  17

Ile Thr Asn Ser Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr 
1               5                   10                  15      


Ile Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          


Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala 
        35                  40                  45              


Ala Leu Val Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala 
    50                  55                  60                  


Gly Val Arg Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp 
65                  70                  75                  80  


Val Ser Leu Leu Ala Glu Val Ser Glu Ala Ala Asp Val His Ile Val 
                85                  90                  95      


Ala Ala Thr Gly Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg 
            100                 105                 110         


Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly 
        115                 120                 125             


Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn 
    130                 135                 140                 


Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg 
145                 150                 155                 160 


Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Asp Ala Ser 
                165                 170                 175     


Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         


Asp Pro Ser Arg Val Cys Ile Gly His Ser Asp Gly Thr Asp Asp Leu 
        195                 200                 205             


Asp Tyr Leu Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp 
    210                 215                 220                 


Gly Ile Pro His Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser 
225                 230                 235                 240 


Ala Leu Leu Gly Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     


Ala Leu Ile Asp Gln Gly Tyr Val Lys Gln Ile Leu Val Ser Asn Asp 
            260                 265                 270         


Trp Leu Phe Gly Phe Ser Ser Trp Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             


Asp Ser Val Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile 
    290                 295                 300                 


Pro Phe Leu Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Thr Ile 
305                 310                 315                 320 


Thr Val Glu Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330                 335     


<210>  18
<211>  1017
<212>  DNA
<213>  Artificial sequence

<220>
<223>  1-3-D5  nucleic acid sequence

<400>  18
atgatcacca acagcggcga ccgtatcaac accgtccgtg gtccgatcac catctctgag       60

gcgggcttca ccctgactca cgaacacatt tgcggttcta gcgcaggttt tctgcgcgct      120

tggccggagt ttttcggttc tcgtgctgct ctggtggaaa aagcggttcg tggcctgcgt      180

cgtgcgcgtg cggctggtgt gcgtaccatc gttgacgttt ctaccttcga cattggtcgt      240

gatgtttctc tgctggccga ggtttctgaa gcggccgatg ttcacattgt tgcagcgact      300

ggtctgtggg aagatccgcc gctgtctatg cgtctgcgct ctgttgaaga actcacccag      360

ttctttctcc gtgaaatcca gtacggcatc gaggacacgg gtatccgtgc cggtatcatt      420

aaagttgcca ccaacggtaa agcgaccccg tttcaggaac tggttctgcg tgcagcagct      480

cgtgcctccc tcgccaccgg cgttccggtc accacccaca ccgacgcttc tcagcgtgac      540

ggtgaacagc aggcggcgat cttcgaaagc gaaggtctgg acccgtctcg tgtttgtatc      600

ggtcactctg acggcaccga tgatctggac tacctgaccg cgctcgcggc tcgtggttac      660

ctgattggcc tggatggtat tccgcactct gcgatcggcc tcgaagacaa cgcatctgcg      720

tccgctctgc tcggtaatcg ctcttggcag acccgtgcgc tgctgatcaa agcgctgatc      780

gaccagggct acgttaaaca gatcctggtt tctaacgatt ggctgttcgg tttttcttct      840

tgggttacca acatcatgga cgttatggac tctgttaacc cagacggtat ggcgttcatc      900

ccgctgcgtg ttatcccgtt cctgcgcgag aaaggtgttc cacaagagac gctggcgacc      960

atcaccgttg aaaaccctgc tcgtttcctg tctccaaccc tccgtgcttc ttgataa        1017


<210>  19
<211>  336
<212>  PRT
<213>  Artificial sequence

<220>
<223>  10-2-C3 amino acid sequence

<400>  19

Ile Thr Asn Ser Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr 
1               5                   10                  15      


Ile Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          


Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala 
        35                  40                  45              


Ala Leu Met Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala 
    50                  55                  60                  


Gly Val Arg Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp 
65                  70                  75                  80  


Val Ser Leu Leu Ala Glu Val Ser Glu Ala Ala Asp Val His Ile Val 
                85                  90                  95      


Ala Ala Thr Gly Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg 
            100                 105                 110         


Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly 
        115                 120                 125             


Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn 
    130                 135                 140                 


Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg 
145                 150                 155                 160 


Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Asp Ala Ser 
                165                 170                 175     


Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         


Asp Pro Ser Arg Val Cys Ile Gly His Ser Asp Gly Thr Asp Asp Leu 
        195                 200                 205             


Asp Tyr Leu Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp 
    210                 215                 220                 


Gly Ile Pro His Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser 
225                 230                 235                 240 


Ser Trp Leu Gly Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     


Ala Leu Ile Asp Gln Gly Tyr Val Lys Gln Ile Leu Val Ser Asn Asp 
            260                 265                 270         


Trp Leu Phe Gly Phe Ser Ser Trp Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             


Asp Ser Val Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile 
    290                 295                 300                 


Pro Phe Leu Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Thr Ile 
305                 310                 315                 320 


Thr Val Glu Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330                 335     


<210>  20
<211>  1017
<212>  DNA
<213>  Artificial sequence

<220>
<223>  10-2-C3 nucleic acid sequence

<400>  20
atgatcacca acagcggcga ccgtatcaac accgtccgtg gtccgatcac catctctgag       60

gcgggcttca ccctgactca cgaacacatt tgcggttcta gcgcaggttt tctgcgcgct      120

tggccggagt ttttcggttc tcgtgctgct ctgatggaaa aagcggttcg tggcctgcgt      180

cgtgcgcgtg cggctggtgt gcgtaccatc gttgacgttt ctaccttcga cattggtcgt      240

gatgtttctc tgctggccga ggtttctgaa gcggccgatg ttcacattgt tgcagcgact      300

ggtctgtggg aagatccgcc gctgtctatg cgtctgcgct ctgttgaaga actcacccag      360

ttctttctcc gtgaaatcca gtacggcatc gaggacacgg gtatccgtgc cggtatcatt      420

aaagttgcca ccaacggtaa agcgaccccg tttcaggaac tggttctgcg tgcagcagct      480

cgtgcctccc tcgccaccgg cgttccggtc accacccaca ccgacgcttc tcagcgtgac      540

ggtgaacagc aggcggcgat cttcgaaagc gaaggtctgg acccgtctcg tgtttgtatc      600

ggtcactctg acggcaccga tgatctggac tacctgaccg cgctcgcggc tcgtggttac      660

ctgattggcc tggatggtat tccgcactct gcgatcggcc tcgaagacaa cgcatctgcg      720

tcctcctggc tcggtaatcg ctcttggcag acccgtgcgc tgctgatcaa agcgctgatc      780

gaccagggct acgttaaaca gatcctggtt tctaacgatt ggctgttcgg tttttcttct      840

tgggttacca acatcatgga cgttatggac tctgttaacc cagacggtat ggcgttcatc      900

ccgctgcgtg ttatcccgtt cctgcgcgag aaaggtgttc cacaagagac gctggcgacc      960

atcaccgttg aaaaccctgc tcgtttcctg tctccaaccc tccgtgcttc ttgataa        1017


<210>  21
<211>  336
<212>  PRT
<213>  Artificial sequence

<220>
<223>  10-1-D11 amino acid sequence

<400>  21

Ile Thr Asn Ser Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr 
1               5                   10                  15      


Ile Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          


Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala 
        35                  40                  45              


Ala Leu Met Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala 
    50                  55                  60                  


Gly Val Arg Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp 
65                  70                  75                  80  


Val Ser Leu Leu Ala Glu Val Ser Glu Ala Ala Asp Val His Ile Val 
                85                  90                  95      


Ala Ala Thr Gly Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg 
            100                 105                 110         


Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly 
        115                 120                 125             


Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn 
    130                 135                 140                 


Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg 
145                 150                 155                 160 


Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Asp Ala Ser 
                165                 170                 175     


Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         


Asp Pro Ser Arg Val Cys Ile Gly His Ser Asp Gly Thr Asp Asp Leu 
        195                 200                 205             


Asp Tyr Leu Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp 
    210                 215                 220                 


Gly Ile Pro His Ser Ala Ile Gly Leu Glu Asp Asn Ala Met Ala Ser 
225                 230                 235                 240 


Ser Trp Leu Gly Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     


Ala Leu Ile Asp Gln Gly Tyr Val Lys Gln Ile Leu Val Ser Asn Asp 
            260                 265                 270         


Trp Leu Phe Gly Phe Ser Ser Trp Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             


Asp Ser Val Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile 
    290                 295                 300                 


Pro Phe Leu Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Thr Ile 
305                 310                 315                 320 


Thr Val Glu Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330                 335     


<210>  22
<211>  1017
<212>  DNA
<213>  Artificial sequence

<220>
<223>  10-1-D11 nucleic acid sequence

<400>  22
atgatcacca acagcggcga ccgtatcaac accgtccgtg gtccgatcac catctctgag       60

gcgggcttca ccctgactca cgaacacatt tgcggttcta gcgcaggttt tctgcgcgct      120

tggccggagt ttttcggttc tcgtgctgct ctgatggaaa aagcggttcg tggcctgcgt      180

cgtgcgcgtg cggctggtgt gcgtaccatc gttgacgttt ctaccttcga cattggtcgt      240

gatgtttctc tgctggccga ggtttctgaa gcggccgatg ttcacattgt tgcagcgact      300

ggtctgtggg aagatccgcc gctgtctatg cgtctgcgct ctgttgaaga actcacccag      360

ttctttctcc gtgaaatcca gtacggcatc gaggacacgg gtatccgtgc cggtatcatt      420

aaagttgcca ccaacggtaa agcgaccccg tttcaggaac tggttctgcg tgcagcagct      480

cgtgcctccc tcgccaccgg cgttccggtc accacccaca ccgacgcttc tcagcgtgac      540

ggtgaacagc aggcggcgat cttcgaaagc gaaggtctgg acccgtctcg tgtttgtatc      600

ggtcactctg acggcaccga tgatctggac tacctgaccg cgctcgcggc tcgtggttac      660

ctgattggcc tggatggtat tccgcactct gcgatcggcc tcgaagacaa cgcaatggcg      720

tcctcttggc tcggtaatcg ctcttggcag acccgtgcgc tgctgatcaa agcgctgatc      780

gaccagggct acgttaaaca gatcctggtt tctaacgatt ggctgttcgg tttttcttct      840

tgggttacca acatcatgga cgttatggac tctgttaacc cagacggtat ggcgttcatc      900

ccgctgcgtg ttatcccgtt cctgcgcgag aaaggtgttc cacaagagac gctggcgacc      960

atcaccgttg aaaaccctgc tcgtttcctg tctccaaccc tccgtgcttc ttgataa        1017


<210>  23
<211>  336
<212>  PRT
<213>  Artificial sequence

<220>
<223>  10-1-D11-I106A amino acid sequence

<400>  23

Ile Thr Asn Ser Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr 
1               5                   10                  15      


Ile Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          


Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala 
        35                  40                  45              


Ala Leu Met Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala 
    50                  55                  60                  


Gly Val Arg Thr Ile Val Asp Val Ser Thr Phe Asp Ala Gly Arg Asp 
65                  70                  75                  80  


Val Ser Leu Leu Ala Glu Val Ser Glu Ala Ala Asp Val His Ile Val 
                85                  90                  95      


Ala Ala Thr Gly Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg 
            100                 105                 110         


Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly 
        115                 120                 125             


Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn 
    130                 135                 140                 


Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg 
145                 150                 155                 160 


Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Asp Ala Ser 
                165                 170                 175     


Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         


Asp Pro Ser Arg Val Cys Ile Gly His Ser Asp Gly Thr Asp Asp Leu 
        195                 200                 205             


Asp Tyr Leu Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp 
    210                 215                 220                 


Gly Ile Pro His Ser Ala Ile Gly Leu Glu Asp Asn Ala Met Ala Ser 
225                 230                 235                 240 


Ser Trp Leu Gly Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     


Ala Leu Ile Asp Gln Gly Tyr Val Lys Gln Ile Leu Val Ser Asn Asp 
            260                 265                 270         


Trp Leu Phe Gly Phe Ser Ser Trp Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             


Asp Ser Val Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile 
    290                 295                 300                 


Pro Phe Leu Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Thr Ile 
305                 310                 315                 320 


Thr Val Glu Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330                 335     


<210>  24
<211>  1017
<212>  DNA
<213>  Artificial sequence

<220>
<223>  10-1-D11I106A nucleic acid sequence

<400>  24
atgatcacca acagcggcga ccgtatcaac accgtccgtg gtccgatcac catctctgag       60

gcgggcttca ccctgactca cgaacacatt tgcggttcta gcgcaggttt tctgcgcgct      120

tggccggagt ttttcggttc tcgtgctgct ctgatggaaa aagcggttcg tggcctgcgt      180

cgtgcgcgtg cggctggtgt gcgtaccatc gttgacgttt ctaccttcga cgccggtcgt      240

gatgtttctc tgctggccga ggtttctgaa gcggccgatg ttcacattgt tgcagcgact      300

ggtctgtggg aagatccgcc gctgtctatg cgtctgcgct ctgttgaaga actcacccag      360

ttctttctcc gtgaaatcca gtacggcatc gaggacacgg gtatccgtgc cggtatcatt      420

aaagttgcca ccaacggtaa agcgaccccg tttcaggaac tggttctgcg tgcagcagct      480

cgtgcctccc tcgccaccgg cgttccggtc accacccaca ccgacgcttc tcagcgtgac      540

ggtgaacagc aggcggcgat cttcgaaagc gaaggtctgg acccgtctcg tgtttgtatc      600

ggtcactctg acggcaccga tgatctggac tacctgaccg cgctcgcggc tcgtggttac      660

ctgattggcc tggatggtat tccgcactct gcgatcggcc tcgaagacaa cgcaatggcg      720

tcctcctggc tcggtaatcg ctcttggcag acccgtgcgc tgctgatcaa agcgctgatc      780

gaccagggct acgttaaaca gatcctggtt tctaacgatt ggctgttcgg tttttcttct      840

tgggttacca acatcatgga cgttatggac tctgttaacc cagacggtat ggcgttcatc      900

ccgctgcgtg ttatcccgtt cctgcgcgag aaaggtgttc cacaagagac gctggcgacc      960

atcaccgttg aaaaccctgc tcgtttcctg tctccaaccc tccgtgcttc ttgataa        1017


<210>  25
<211>  727
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MBP-1-3-D5-I106A amino acid sequence

<400>  25

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365             


Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly Ile 
    370                 375                 380                 


Glu Gly Arg Ile Ser Glu Phe Ile Thr Asn Ser Gly Asp Arg Ile Asn 
385                 390                 395                 400 


Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala Gly Phe Thr Leu Thr 
                405                 410                 415     


His Glu His Ile Cys Gly Ser Ser Ala Gly Phe Leu Arg Ala Trp Pro 
            420                 425                 430         


Glu Phe Phe Gly Ser Arg Ala Ala Leu Val Glu Lys Ala Val Arg Gly 
        435                 440                 445             


Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr Ile Val Asp Val Ser 
    450                 455                 460                 


Thr Phe Asp Ala Gly Arg Asp Val Ser Leu Leu Ala Glu Val Ser Glu 
465                 470                 475                 480 


Ala Ala Asp Val His Ile Val Ala Ala Thr Gly Leu Trp Glu Asp Pro 
                485                 490                 495     


Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu Leu Thr Gln Phe Phe 
            500                 505                 510         


Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr Gly Ile Arg Ala Gly 
        515                 520                 525             


Ile Ile Lys Val Ala Thr Asn Gly Lys Ala Thr Pro Phe Gln Glu Leu 
    530                 535                 540                 


Val Leu Arg Ala Ala Ala Arg Ala Ser Leu Ala Thr Gly Val Pro Val 
545                 550                 555                 560 


Thr Thr His Thr Asp Ala Ser Gln Arg Asp Gly Glu Gln Gln Ala Ala 
                565                 570                 575     


Ile Phe Glu Ser Glu Gly Leu Asp Pro Ser Arg Val Cys Ile Gly His 
            580                 585                 590         


Ser Asp Gly Thr Asp Asp Leu Asp Tyr Leu Thr Ala Leu Ala Ala Arg 
        595                 600                 605             


Gly Tyr Leu Ile Gly Leu Asp Gly Ile Pro His Ser Ala Ile Gly Leu 
    610                 615                 620                 


Glu Asp Asn Ala Ser Ala Ser Ala Leu Leu Gly Asn Arg Ser Trp Gln 
625                 630                 635                 640 


Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp Gln Gly Tyr Val Lys 
                645                 650                 655     


Gln Ile Leu Val Ser Asn Asp Trp Leu Phe Gly Phe Ser Ser Trp Val 
            660                 665                 670         


Thr Asn Ile Met Asp Val Met Asp Ser Val Asn Pro Asp Gly Met Ala 
        675                 680                 685             


Phe Ile Pro Leu Arg Val Ile Pro Phe Leu Arg Glu Lys Gly Val Pro 
    690                 695                 700                 


Gln Glu Thr Leu Ala Thr Ile Thr Val Glu Asn Pro Ala Arg Phe Leu 
705                 710                 715                 720 


Ser Pro Thr Leu Arg Ala Ser 
                725         


<210>  26
<211>  336
<212>  PRT
<213>  Artificial sequence

<220>
<223>  1-3-D5-I106A amino acid sequence

<400>  26

Ile Thr Asn Ser Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr 
1               5                   10                  15      


Ile Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          


Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala 
        35                  40                  45              


Ala Leu Val Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala 
    50                  55                  60                  


Gly Val Arg Thr Ile Val Asp Val Ser Thr Phe Asp Ala Gly Arg Asp 
65                  70                  75                  80  


Val Ser Leu Leu Ala Glu Val Ser Glu Ala Ala Asp Val His Ile Val 
                85                  90                  95      


Ala Ala Thr Gly Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg 
            100                 105                 110         


Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly 
        115                 120                 125             


Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn 
    130                 135                 140                 


Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg 
145                 150                 155                 160 


Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Asp Ala Ser 
                165                 170                 175     


Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         


Asp Pro Ser Arg Val Cys Ile Gly His Ser Asp Gly Thr Asp Asp Leu 
        195                 200                 205             


Asp Tyr Leu Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp 
    210                 215                 220                 


Gly Ile Pro His Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser 
225                 230                 235                 240 


Ala Leu Leu Gly Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     


Ala Leu Ile Asp Gln Gly Tyr Val Lys Gln Ile Leu Val Ser Asn Asp 
            260                 265                 270         


Trp Leu Phe Gly Phe Ser Ser Trp Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             


Asp Ser Val Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile 
    290                 295                 300                 


Pro Phe Leu Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Thr Ile 
305                 310                 315                 320 


Thr Val Glu Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330                 335     


<210>  27
<211>  727
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MBP-10-2-C3-I106A + MBP amino acid sequence

<400>  27

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365             


Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly Ile 
    370                 375                 380                 


Glu Gly Arg Ile Ser Glu Phe Ile Thr Asn Ser Gly Asp Arg Ile Asn 
385                 390                 395                 400 


Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala Gly Phe Thr Leu Thr 
                405                 410                 415     


His Glu His Ile Cys Gly Ser Ser Ala Gly Phe Leu Arg Ala Trp Pro 
            420                 425                 430         


Glu Phe Phe Gly Ser Arg Ala Ala Leu Met Glu Lys Ala Val Arg Gly 
        435                 440                 445             


Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr Ile Val Asp Val Ser 
    450                 455                 460                 


Thr Phe Asp Ala Gly Arg Asp Val Ser Leu Leu Ala Glu Val Ser Glu 
465                 470                 475                 480 


Ala Ala Asp Val His Ile Val Ala Ala Thr Gly Leu Trp Glu Asp Pro 
                485                 490                 495     


Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu Leu Thr Gln Phe Phe 
            500                 505                 510         


Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr Gly Ile Arg Ala Gly 
        515                 520                 525             


Ile Ile Lys Val Ala Thr Asn Gly Lys Ala Thr Pro Phe Gln Glu Leu 
    530                 535                 540                 


Val Leu Arg Ala Ala Ala Arg Ala Ser Leu Ala Thr Gly Val Pro Val 
545                 550                 555                 560 


Thr Thr His Thr Asp Ala Ser Gln Arg Asp Gly Glu Gln Gln Ala Ala 
                565                 570                 575     


Ile Phe Glu Ser Glu Gly Leu Asp Pro Ser Arg Val Cys Ile Gly His 
            580                 585                 590         


Ser Asp Gly Thr Asp Asp Leu Asp Tyr Leu Thr Ala Leu Ala Ala Arg 
        595                 600                 605             


Gly Tyr Leu Ile Gly Leu Asp Gly Ile Pro His Ser Ala Ile Gly Leu 
    610                 615                 620                 


Glu Asp Asn Ala Ser Ala Ser Ser Trp Leu Gly Asn Arg Ser Trp Gln 
625                 630                 635                 640 


Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp Gln Gly Tyr Val Lys 
                645                 650                 655     


Gln Ile Leu Val Ser Asn Asp Trp Leu Phe Gly Phe Ser Ser Trp Val 
            660                 665                 670         


Thr Asn Ile Met Asp Val Met Asp Ser Val Asn Pro Asp Gly Met Ala 
        675                 680                 685             


Phe Ile Pro Leu Arg Val Ile Pro Phe Leu Arg Glu Lys Gly Val Pro 
    690                 695                 700                 


Gln Glu Thr Leu Ala Thr Ile Thr Val Glu Asn Pro Ala Arg Phe Leu 
705                 710                 715                 720 


Ser Pro Thr Leu Arg Ala Ser 
                725         


<210>  28
<211>  336
<212>  PRT
<213>  Artificial sequence

<220>
<223>  10-2-C3-I106A amino acid sequence

<400>  28

Ile Thr Asn Ser Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr 
1               5                   10                  15      


Ile Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          


Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala 
        35                  40                  45              


Ala Leu Met Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala 
    50                  55                  60                  


Gly Val Arg Thr Ile Val Asp Val Ser Thr Phe Asp Ala Gly Arg Asp 
65                  70                  75                  80  


Val Ser Leu Leu Ala Glu Val Ser Glu Ala Ala Asp Val His Ile Val 
                85                  90                  95      


Ala Ala Thr Gly Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg 
            100                 105                 110         


Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly 
        115                 120                 125             


Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn 
    130                 135                 140                 


Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg 
145                 150                 155                 160 


Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Asp Ala Ser 
                165                 170                 175     


Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         


Asp Pro Ser Arg Val Cys Ile Gly His Ser Asp Gly Thr Asp Asp Leu 
        195                 200                 205             


Asp Tyr Leu Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp 
    210                 215                 220                 


Gly Ile Pro His Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser 
225                 230                 235                 240 


Ser Trp Leu Gly Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     


Ala Leu Ile Asp Gln Gly Tyr Val Lys Gln Ile Leu Val Ser Asn Asp 
            260                 265                 270         


Trp Leu Phe Gly Phe Ser Ser Trp Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             


Asp Ser Val Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile 
    290                 295                 300                 


Pro Phe Leu Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Thr Ile 
305                 310                 315                 320 


Thr Val Glu Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330                 335     


<210>  29
<211>  366
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MBPalone amino acid sequence

<400>  29

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln 
        355                 360                 365     


<210>  30
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker amino acid sequence

<400>  30

Thr Asn Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu 
1               5                   10                  15      


Gly Ile Glu Gly Arg Ile Ser Glu Phe 
            20                  25  


<210>  31
<211>  727
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MBP-C23  amino acid sequence

<400>  31

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365             


Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly Ile 
    370                 375                 380                 


Glu Gly Arg Ile Ser Glu Phe Ile Thr Asn Ser Gly Asp Arg Ile Asn 
385                 390                 395                 400 


Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala Gly Phe Thr Leu Thr 
                405                 410                 415     


His Glu His Ile Cys Gly Ser Ser Ala Gly Phe Leu Arg Ala Trp Pro 
            420                 425                 430         


Glu Phe Phe Gly Ser Arg Ala Ala Leu Val Glu Lys Ala Val Arg Gly 
        435                 440                 445             


Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr Ile Val Asp Val Ser 
    450                 455                 460                 


Thr Phe Asp Ile Gly Arg Asp Val Ser Leu Leu Ala Glu Val Ser Arg 
465                 470                 475                 480 


Ala Ala Asp Val His Ile Val Ala Ala Thr Gly Leu Trp Glu Asp Pro 
                485                 490                 495     


Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu Leu Thr Gln Phe Phe 
            500                 505                 510         


Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr Gly Ile Arg Ala Gly 
        515                 520                 525             


Ile Ile Lys Val Ala Thr Asn Gly Lys Ala Thr Pro Phe Gln Glu Leu 
    530                 535                 540                 


Val Leu Arg Ala Ala Ala Arg Ala Ser Leu Ala Thr Gly Val Pro Val 
545                 550                 555                 560 


Thr Thr His Thr Ala Ala Ser Gln Arg Asp Gly Glu Gln Gln Ala Ala 
                565                 570                 575     


Ile Phe Glu Ser Glu Gly Leu Ser Pro Ser Arg Val Cys Ile Gly His 
            580                 585                 590         


Ser Asp Asp Thr Asp Asp Leu Ser Tyr Leu Thr Ala Leu Ala Ala Arg 
        595                 600                 605             


Gly Tyr Leu Ile Gly Leu Asp Gly Ile Pro His Ser Ala Ile Gly Leu 
    610                 615                 620                 


Glu Asp Asn Ala Ser Ala Ser Ala Leu Leu Gly Asn Arg Ser Trp Gln 
625                 630                 635                 640 


Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp Gln Gly Tyr Met Lys 
                645                 650                 655     


Gln Ile Leu Val Ser Asn Asp Trp Leu Phe Gly Phe Ser Ser Tyr Val 
            660                 665                 670         


Thr Asn Ile Met Asp Val Met Asp Ser Val Asn Pro Asp Gly Met Ala 
        675                 680                 685             


Phe Ile Pro Leu Arg Val Ile Pro Phe Leu Arg Glu Lys Gly Val Ser 
    690                 695                 700                 


Gln Glu Thr Leu Ala Gly Ile Thr Val Thr Asn Pro Ala Arg Phe Leu 
705                 710                 715                 720 


Ser Pro Thr Leu Arg Ala Ser 
                725         


<210>  32
<211>  2187
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MBP-C23  nucleic acid sequence

<400>  32
atgaaaatcg aagaaggtaa actggtaatc tggattaacg gcgataaagg ctataacggt       60

ctcgctgaag tcggtaagaa attcgagaaa gataccggaa ttaaagtcac cgttgagcat      120

ccggataaac tggaagagaa attcccacag gttgcggcaa ctggcgatgg ccctgacatt      180

atcttctggg cacacgaccg ctttggtggc tacgctcaat ctggcctgtt ggctgaaatc      240

accccggaca aagcgttcca ggacaagctg tatccgttta cctgggatgc cgtacgttac      300

aacggcaagc tgattgctta cccgatcgct gttgaagcgt tatcgctgat ttataacaaa      360

gatctgctgc cgaacccgcc aaaaacctgg gaagagatcc cggcgctgga taaagaactg      420

aaagcgaaag gtaagagcgc gctgatgttc aacctgcaag aaccgtactt cacctggccg      480

ctgattgctg ctgacggggg ttatgcgttc aagtatgaaa acggcaagta cgacattaaa      540

gacgtgggcg tggataacgc tggcgcgaaa gcgggtctga ccttcctggt tgacctgatt      600

aaaaacaaac acatgaatgc agacaccgat tactccatcg cagaagctgc ctttaataaa      660

ggcgaaacag cgatgaccat caacggcccg tgggcatggt ccaacatcga caccagcaaa      720

gtgaattatg gtgtaacggt actgccgacc ttcaagggtc aaccatccaa accgttcgtt      780

ggcgtgctga gcgcaggtat taacgccgcc agtccgaaca aagagctggc aaaagagttc      840

ctcgaaaact atctgctgac tgatgaaggt ctggaagcgg ttaataaaga caaaccgctg      900

ggtgccgtag cgctgaagtc ttacgaggaa gagttggcga aagatccacg tattgccgcc      960

actatggaaa acgcccagaa aggtgaaatc atgccgaaca tcccgcagat gtccgctttc     1020

tggtatgccg tgcgtactgc ggtgatcaac gccgccagcg gtcgtcagac tgtcgatgaa     1080

gccctgaaag acgcgcagac taattcgagc tcgaacaaca acaacaataa caataacaac     1140

aacctcggga tcgagggaag gatttcagaa ttcatcacca acagcggcga tcggatcaat     1200

accgtgcgcg gtcctatcac aatctctgaa gcgggtttca cactgactca cgagcacatc     1260

tgcggcagct cggcaggatt cttgcgtgct tggccggagt tcttcggtag ccgcgcagcc     1320

ctagtggaaa aggctgtgag aggattgcgc cgcgccagag cggctggcgt gcgaacgatt     1380

gtcgatgtgt cgactttcga tatcggtcgc gatgtcagtt tattggccga ggtttcgcgg     1440

gctgccgacg ttcatatcgt ggcggcgacc ggcttgtggg aggacccgcc actttcgatg     1500

cggttgagga gtgtagagga actcacacag ttcttcctgc gtgagattca atatggcatc     1560

gaagacaccg gaattagggc gggcattatc aaggtcgcga ccaatggcaa ggcgaccccc     1620

tttcaggagt tagtgttaag ggcggccgcc cgggccagct tggccaccgg tgttccggta     1680

accactcaca cggcagcaag tcagcgcgat ggtgagcagc aggccgccat ttttgagtcc     1740

gaaggcttga gcccctcacg agtttgtatt ggtcacagcg atgatactga cgatttgagc     1800

tatctcaccg ccctcgctgc gcgcggatac ctcatcggtc tagacggcat cccgcacagt     1860

gcgattggtc tagaagataa tgcgagtgca tcagccctcc tgggcaaccg ttcgtggcaa     1920

acacgggctc tcttgatcaa ggcgctcatc gaccaaggct acatgaaaca aatcctcgtt     1980

tcgaatgact ggctgttcgg gttttcgagc tatgtcacca acatcatgga cgtgatggat     2040

agcgtgaacc ccgacgggat ggccttcatt ccactgagag tgatcccatt cctacgagag     2100

aagggcgtct cacaggaaac gctggcaggc atcactgtga ccaacccggc gcggttcttg     2160

tcaccgacct tgcgggcgtc atgataa                                         2187


<210>  33
<211>  336
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C23  amino acid sequence

<400>  33

Ile Thr Asn Ser Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr 
1               5                   10                  15      


Ile Ser Glu Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser 
            20                  25                  30          


Ser Ala Gly Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala 
        35                  40                  45              


Ala Leu Val Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala 
    50                  55                  60                  


Gly Val Arg Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp 
65                  70                  75                  80  


Val Ser Leu Leu Ala Glu Val Ser Arg Ala Ala Asp Val His Ile Val 
                85                  90                  95      


Ala Ala Thr Gly Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg 
            100                 105                 110         


Ser Val Glu Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly 
        115                 120                 125             


Ile Glu Asp Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn 
    130                 135                 140                 


Gly Lys Ala Thr Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg 
145                 150                 155                 160 


Ala Ser Leu Ala Thr Gly Val Pro Val Thr Thr His Thr Ala Ala Ser 
                165                 170                 175     


Gln Arg Asp Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu 
            180                 185                 190         


Ser Pro Ser Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu 
        195                 200                 205             


Ser Tyr Leu Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp 
    210                 215                 220                 


Gly Ile Pro His Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser 
225                 230                 235                 240 


Ala Leu Leu Gly Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys 
                245                 250                 255     


Ala Leu Ile Asp Gln Gly Tyr Met Lys Gln Ile Leu Val Ser Asn Asp 
            260                 265                 270         


Trp Leu Phe Gly Phe Ser Ser Tyr Val Thr Asn Ile Met Asp Val Met 
        275                 280                 285             


Asp Ser Val Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile 
    290                 295                 300                 


Pro Phe Leu Arg Glu Lys Gly Val Ser Gln Glu Thr Leu Ala Gly Ile 
305                 310                 315                 320 


Thr Val Thr Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330                 335     


<210>  34
<211>  1017
<212>  DNA
<213>  Artificial sequence

<220>
<223>  C23  nucleic acid sequence

<400>  34
atgatcacca acagcggcga tcggatcaat accgtgcgcg gtcctatcac aatctctgaa       60

gcgggtttca cactgactca cgagcacatc tgcggcagct cggcaggatt cttgcgtgct      120

tggccggagt tcttcggtag ccgcgcagcc ctagtggaaa aggctgtgag aggattgcgc      180

cgcgccagag cggctggcgt gcgaacgatt gtcgatgtgt cgactttcga tatcggtcgc      240

gatgtcagtt tattggccga ggtttcgcgg gctgccgacg ttcatatcgt ggcggcgacc      300

ggcttgtggg aggacccgcc actttcgatg cggttgagga gtgtagagga actcacacag      360

ttcttcctgc gtgagattca atatggcatc gaagacaccg gaattagggc gggcattatc      420

aaggtcgcga ccaatggcaa ggcgaccccc tttcaggagt tagtgttaag ggcggccgcc      480

cgggccagct tggccaccgg tgttccggta accactcaca cggcagcaag tcagcgcgat      540

ggtgagcagc aggccgccat ttttgagtcc gaaggcttga gcccctcacg agtttgtatt      600

ggtcacagcg atgatactga cgatttgagc tatctcaccg ccctcgctgc gcgcggatac      660

ctcatcggtc tagacggcat cccgcacagt gcgattggtc tagaagataa tgcgagtgca      720

tcagccctcc tgggcaaccg ttcgtggcaa acacgggctc tcttgatcaa ggcgctcatc      780

gaccaaggct acatgaaaca aatcctcgtt tcgaatgact ggctgttcgg gttttcgagc      840

tatgtcacca acatcatgga cgtgatggat agcgtgaacc ccgacgggat ggccttcatt      900

ccactgagag tgatcccatt cctacgagag aagggcgtct cacaggaaac gctggcaggc      960

atcactgtga ccaacccggc gcggttcttg tcaccgacct tgcgggcgtc atgataa        1017


<210>  35
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  first 29 amino acids sequence of wild-type PTE

<400>  35

Met Gln Thr Arg Arg Val Val Leu Lys Ser Ala Ala Ala Ala Gly Thr 
1               5                   10                  15      


Leu Leu Gly Gly Leu Ala Gly Cys Ala Ser Val Ala Gly 
            20                  25                  


<210>  36
<211>  365
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PTE Full length for numbering

<400>  36

Met Gln Thr Arg Arg Val Val Leu Lys Ser Ala Ala Ala Ala Gly Thr 
1               5                   10                  15      


Leu Leu Gly Gly Leu Ala Gly Cys Ala Ser Val Ala Gly Ser Ile Gly 
            20                  25                  30          


Thr Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr Ile Ser Glu 
        35                  40                  45              


Ala Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser Ser Ala Gly 
    50                  55                  60                  


Phe Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Lys Ala Leu Ala 
65                  70                  75                  80  


Glu Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala Gly Val Arg 
                85                  90                  95      


Thr Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp Val Ser Leu 
            100                 105                 110         


Leu Ala Glu Val Ser Arg Ala Ala Asp Val His Ile Val Ala Ala Thr 
        115                 120                 125             


Gly Leu Trp Phe Asp Pro Pro Leu Ser Met Arg Leu Arg Ser Val Glu 
    130                 135                 140                 


Glu Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp 
145                 150                 155                 160 


Thr Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Thr Gly Lys Ala 
                165                 170                 175     


Thr Pro Phe Gln Glu Leu Val Leu Lys Ala Ala Ala Arg Ala Ser Leu 
            180                 185                 190         


Ala Thr Gly Val Pro Val Thr Thr His Thr Ala Ala Ser Gln Arg Asp 
        195                 200                 205             


Gly Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu Ser Pro Ser 
    210                 215                 220                 


Arg Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu Ser Tyr Leu 
225                 230                 235                 240 


Thr Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp His Ile Pro 
                245                 250                 255     


His Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser Ala Leu Leu 
            260                 265                 270         


Gly Ile Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile 
        275                 280                 285             


Asp Gln Gly Tyr Met Lys Gln Ile Leu Val Ser Asn Asp Trp Leu Phe 
    290                 295                 300                 


Gly Phe Ser Ser Tyr Val Thr Asn Ile Met Asp Val Met Asp Arg Val 
305                 310                 315                 320 


Asn Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile Pro Phe Leu 
                325                 330                 335     


Arg Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Gly Ile Thr Val Thr 
            340                 345                 350         


Asn Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
        355                 360                 365 


<210>  37
<211>  332
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PTE  wild type like S5 amino acid sequence

<400>  37

Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala 
1               5                   10                  15      


Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser Ser Ala Gly Phe 
            20                  25                  30          


Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Lys Ala Leu Ala Glu 
        35                  40                  45              


Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr 
    50                  55                  60                  


Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp Val Ser Leu Leu 
65                  70                  75                  80  


Ala Glu Val Ser Arg Ala Ala Asp Val His Ile Val Ala Ala Thr Gly 
                85                  90                  95      


Leu Trp Phe Asp Pro Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu 
            100                 105                 110         


Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr 
        115                 120                 125             


Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Thr Gly Lys Ala Thr 
    130                 135                 140                 


Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg Ala Ser Leu Ala 
145                 150                 155                 160 


Thr Gly Val Pro Val Thr Thr His Thr Ala Ala Ser Gln Arg Gly Gly 
                165                 170                 175     


Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu Ser Pro Ser Arg 
            180                 185                 190         


Val Cys Ile Gly His Ser Asp Asp Thr Asp Asp Leu Ser Tyr Leu Thr 
        195                 200                 205             


Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp His Ile Pro His 
    210                 215                 220                 


Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser Ala Leu Leu Gly 
225                 230                 235                 240 


Ile Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp 
                245                 250                 255     


Gln Gly Tyr Met Lys Gln Ile Leu Val Ser Asn Asp Trp Leu Phe Gly 
            260                 265                 270         


Phe Ser Ser Tyr Val Thr Asn Ile Met Asp Val Met Asp Ser Val Asn 
        275                 280                 285             


Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile Pro Phe Leu Arg 
    290                 295                 300                 


Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Gly Ile Thr Val Thr Asn 
305                 310                 315                 320 


Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330         


<210>  38
<211>  331
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IVA1-m2p0  amino acid sequence

<400>  38

Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala 
1               5                   10                  15      


Gly Phe Thr Leu Thr His Glu His Ile Met Gly Ser Ser Ala Gly Phe 
            20                  25                  30          


Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala Ala Leu Val Glu 
        35                  40                  45              


Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr 
    50                  55                  60                  


Ile Val Asp Val Ser Thr Phe Asp Ala Gly Arg Asp Val Ser Leu Leu 
65                  70                  75                  80  


Ala Glu Val Ser Glu Ala Ala Asp Val His Ile Val Ala Ala Thr Gly 
                85                  90                  95      


Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu 
            100                 105                 110         


Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr 
        115                 120                 125             


Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn Gly Lys Ala Thr 
    130                 135                 140                 


Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg Ala Ser Leu Ala 
145                 150                 155                 160 


Thr Gly Val Pro Val Thr Thr His Thr Asp Ala Ser Gln Arg Asp Gly 
                165                 170                 175     


Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu Asp Pro Ser Arg 
            180                 185                 190         


Val Cys Ile Gly His Ser Asp Gly Thr Asp Asp Leu Asp Tyr Leu Thr 
        195                 200                 205             


Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp Gly Ile Pro His 
    210                 215                 220                 


Ser Ala Ile Gly Leu Glu Asp Asn Ser Ala Ser Ala Leu Leu Gly Asn 
225                 230                 235                 240 


Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp Gln 
                245                 250                 255     


Gly Tyr Val Lys Gln Ile Leu Val Ser Asn Asp Trp Leu Phe Gly Phe 
            260                 265                 270         


Ser Ser Trp Val Thr Asn Ile Met Asp Val Met Asp Ser Val Asn Pro 
        275                 280                 285             


Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile Pro Phe Leu Arg Glu 
    290                 295                 300                 


Lys Gly Val Pro Gln Glu Thr Leu Ala Thr Ile Thr Val Glu Asn Pro 
305                 310                 315                 320 


Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330     


<210>  39
<211>  332
<212>  PRT
<213>  Artificial sequence

<220>
<223>  1-3-D5  amino acid sequence

<400>  39

Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala 
1               5                   10                  15      


Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser Ser Ala Gly Phe 
            20                  25                  30          


Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala Ala Leu Val Glu 
        35                  40                  45              


Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr 
    50                  55                  60                  


Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp Val Ser Leu Leu 
65                  70                  75                  80  


Ala Glu Val Ser Glu Ala Ala Asp Val His Ile Val Ala Ala Thr Gly 
                85                  90                  95      


Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu 
            100                 105                 110         


Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr 
        115                 120                 125             


Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn Gly Lys Ala Thr 
    130                 135                 140                 


Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg Ala Ser Leu Ala 
145                 150                 155                 160 


Thr Gly Val Pro Val Thr Thr His Thr Asp Ala Ser Gln Arg Asp Gly 
                165                 170                 175     


Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu Asp Pro Ser Arg 
            180                 185                 190         


Val Cys Ile Gly His Ser Asp Gly Thr Asp Asp Leu Asp Tyr Leu Thr 
        195                 200                 205             


Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp Gly Ile Pro His 
    210                 215                 220                 


Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser Ala Leu Leu Gly 
225                 230                 235                 240 


Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp 
                245                 250                 255     


Gln Gly Tyr Val Lys Gln Ile Leu Val Ser Asn Asp Trp Leu Phe Gly 
            260                 265                 270         


Phe Ser Ser Trp Val Thr Asn Ile Met Asp Val Met Asp Ser Val Asn 
        275                 280                 285             


Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile Pro Phe Leu Arg 
    290                 295                 300                 


Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Thr Ile Thr Val Glu Asn 
305                 310                 315                 320 


Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330         


<210>  40
<211>  332
<212>  PRT
<213>  Artificial sequence

<220>
<223>  10-2-C3 amino acid sequence

<400>  40

Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala 
1               5                   10                  15      


Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser Ser Ala Gly Phe 
            20                  25                  30          


Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala Ala Leu Met Glu 
        35                  40                  45              


Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr 
    50                  55                  60                  


Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp Val Ser Leu Leu 
65                  70                  75                  80  


Ala Glu Val Ser Glu Ala Ala Asp Val His Ile Val Ala Ala Thr Gly 
                85                  90                  95      


Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu 
            100                 105                 110         


Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr 
        115                 120                 125             


Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn Gly Lys Ala Thr 
    130                 135                 140                 


Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg Ala Ser Leu Ala 
145                 150                 155                 160 


Thr Gly Val Pro Val Thr Thr His Thr Asp Ala Ser Gln Arg Asp Gly 
                165                 170                 175     


Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu Asp Pro Ser Arg 
            180                 185                 190         


Val Cys Ile Gly His Ser Asp Gly Thr Asp Asp Leu Asp Tyr Leu Thr 
        195                 200                 205             


Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp Gly Ile Pro His 
    210                 215                 220                 


Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser Ser Trp Leu Gly 
225                 230                 235                 240 


Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp 
                245                 250                 255     


Gln Gly Tyr Val Lys Gln Ile Leu Val Ser Asn Asp Trp Leu Phe Gly 
            260                 265                 270         


Phe Ser Ser Trp Val Thr Asn Ile Met Asp Val Met Asp Ser Val Asn 
        275                 280                 285             


Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile Pro Phe Leu Arg 
    290                 295                 300                 


Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Thr Ile Thr Val Glu Asn 
305                 310                 315                 320 


Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330         


<210>  41
<211>  332
<212>  PRT
<213>  Artificial sequence

<220>
<223>  10-1-D11 amino acid sequence

<400>  41

Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala 
1               5                   10                  15      


Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser Ser Ala Gly Phe 
            20                  25                  30          


Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala Ala Leu Met Glu 
        35                  40                  45              


Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr 
    50                  55                  60                  


Ile Val Asp Val Ser Thr Phe Asp Ile Gly Arg Asp Val Ser Leu Leu 
65                  70                  75                  80  


Ala Glu Val Ser Glu Ala Ala Asp Val His Ile Val Ala Ala Thr Gly 
                85                  90                  95      


Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu 
            100                 105                 110         


Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr 
        115                 120                 125             


Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn Gly Lys Ala Thr 
    130                 135                 140                 


Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg Ala Ser Leu Ala 
145                 150                 155                 160 


Thr Gly Val Pro Val Thr Thr His Thr Asp Ala Ser Gln Arg Asp Gly 
                165                 170                 175     


Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu Asp Pro Ser Arg 
            180                 185                 190         


Val Cys Ile Gly His Ser Asp Gly Thr Asp Asp Leu Asp Tyr Leu Thr 
        195                 200                 205             


Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp Gly Ile Pro His 
    210                 215                 220                 


Ser Ala Ile Gly Leu Glu Asp Asn Ala Met Ala Ser Ser Trp Leu Gly 
225                 230                 235                 240 


Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp 
                245                 250                 255     


Gln Gly Tyr Val Lys Gln Ile Leu Val Ser Asn Asp Trp Leu Phe Gly 
            260                 265                 270         


Phe Ser Ser Trp Val Thr Asn Ile Met Asp Val Met Asp Ser Val Asn 
        275                 280                 285             


Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile Pro Phe Leu Arg 
    290                 295                 300                 


Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Thr Ile Thr Val Glu Asn 
305                 310                 315                 320 


Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330         


<210>  42
<211>  332
<212>  PRT
<213>  Artificial sequence

<220>
<223>  10-1-D11-I106A amino acid sequence

<400>  42

Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala 
1               5                   10                  15      


Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser Ser Ala Gly Phe 
            20                  25                  30          


Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala Ala Leu Met Glu 
        35                  40                  45              


Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr 
    50                  55                  60                  


Ile Val Asp Val Ser Thr Phe Asp Ala Gly Arg Asp Val Ser Leu Leu 
65                  70                  75                  80  


Ala Glu Val Ser Glu Ala Ala Asp Val His Ile Val Ala Ala Thr Gly 
                85                  90                  95      


Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu 
            100                 105                 110         


Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr 
        115                 120                 125             


Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn Gly Lys Ala Thr 
    130                 135                 140                 


Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg Ala Ser Leu Ala 
145                 150                 155                 160 


Thr Gly Val Pro Val Thr Thr His Thr Asp Ala Ser Gln Arg Asp Gly 
                165                 170                 175     


Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu Asp Pro Ser Arg 
            180                 185                 190         


Val Cys Ile Gly His Ser Asp Gly Thr Asp Asp Leu Asp Tyr Leu Thr 
        195                 200                 205             


Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp Gly Ile Pro His 
    210                 215                 220                 


Ser Ala Ile Gly Leu Glu Asp Asn Ala Met Ala Ser Ser Trp Leu Gly 
225                 230                 235                 240 


Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp 
                245                 250                 255     


Gln Gly Tyr Val Lys Gln Ile Leu Val Ser Asn Asp Trp Leu Phe Gly 
            260                 265                 270         


Phe Ser Ser Trp Val Thr Asn Ile Met Asp Val Met Asp Ser Val Asn 
        275                 280                 285             


Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile Pro Phe Leu Arg 
    290                 295                 300                 


Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Thr Ile Thr Val Glu Asn 
305                 310                 315                 320 


Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330         


<210>  43
<211>  332
<212>  PRT
<213>  Artificial sequence

<220>
<223>  1-3-D5-I106A amino acid sequence

<400>  43

Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala 
1               5                   10                  15      


Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser Ser Ala Gly Phe 
            20                  25                  30          


Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala Ala Leu Val Glu 
        35                  40                  45              


Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr 
    50                  55                  60                  


Ile Val Asp Val Ser Thr Phe Asp Ala Gly Arg Asp Val Ser Leu Leu 
65                  70                  75                  80  


Ala Glu Val Ser Glu Ala Ala Asp Val His Ile Val Ala Ala Thr Gly 
                85                  90                  95      


Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu 
            100                 105                 110         


Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr 
        115                 120                 125             


Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn Gly Lys Ala Thr 
    130                 135                 140                 


Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg Ala Ser Leu Ala 
145                 150                 155                 160 


Thr Gly Val Pro Val Thr Thr His Thr Asp Ala Ser Gln Arg Asp Gly 
                165                 170                 175     


Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu Asp Pro Ser Arg 
            180                 185                 190         


Val Cys Ile Gly His Ser Asp Gly Thr Asp Asp Leu Asp Tyr Leu Thr 
        195                 200                 205             


Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp Gly Ile Pro His 
    210                 215                 220                 


Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser Ala Leu Leu Gly 
225                 230                 235                 240 


Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp 
                245                 250                 255     


Gln Gly Tyr Val Lys Gln Ile Leu Val Ser Asn Asp Trp Leu Phe Gly 
            260                 265                 270         


Phe Ser Ser Trp Val Thr Asn Ile Met Asp Val Met Asp Ser Val Asn 
        275                 280                 285             


Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile Pro Phe Leu Arg 
    290                 295                 300                 


Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Thr Ile Thr Val Glu Asn 
305                 310                 315                 320 


Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330         


<210>  44
<211>  332
<212>  PRT
<213>  Artificial sequence

<220>
<223>  10-2-C3-I106A amino acid sequence

<400>  44

Gly Asp Arg Ile Asn Thr Val Arg Gly Pro Ile Thr Ile Ser Glu Ala 
1               5                   10                  15      


Gly Phe Thr Leu Thr His Glu His Ile Cys Gly Ser Ser Ala Gly Phe 
            20                  25                  30          


Leu Arg Ala Trp Pro Glu Phe Phe Gly Ser Arg Ala Ala Leu Met Glu 
        35                  40                  45              


Lys Ala Val Arg Gly Leu Arg Arg Ala Arg Ala Ala Gly Val Arg Thr 
    50                  55                  60                  


Ile Val Asp Val Ser Thr Phe Asp Ala Gly Arg Asp Val Ser Leu Leu 
65                  70                  75                  80  


Ala Glu Val Ser Glu Ala Ala Asp Val His Ile Val Ala Ala Thr Gly 
                85                  90                  95      


Leu Trp Glu Asp Pro Pro Leu Ser Met Arg Leu Arg Ser Val Glu Glu 
            100                 105                 110         


Leu Thr Gln Phe Phe Leu Arg Glu Ile Gln Tyr Gly Ile Glu Asp Thr 
        115                 120                 125             


Gly Ile Arg Ala Gly Ile Ile Lys Val Ala Thr Asn Gly Lys Ala Thr 
    130                 135                 140                 


Pro Phe Gln Glu Leu Val Leu Arg Ala Ala Ala Arg Ala Ser Leu Ala 
145                 150                 155                 160 


Thr Gly Val Pro Val Thr Thr His Thr Asp Ala Ser Gln Arg Asp Gly 
                165                 170                 175     


Glu Gln Gln Ala Ala Ile Phe Glu Ser Glu Gly Leu Asp Pro Ser Arg 
            180                 185                 190         


Val Cys Ile Gly His Ser Asp Gly Thr Asp Asp Leu Asp Tyr Leu Thr 
        195                 200                 205             


Ala Leu Ala Ala Arg Gly Tyr Leu Ile Gly Leu Asp Gly Ile Pro His 
    210                 215                 220                 


Ser Ala Ile Gly Leu Glu Asp Asn Ala Ser Ala Ser Ser Trp Leu Gly 
225                 230                 235                 240 


Asn Arg Ser Trp Gln Thr Arg Ala Leu Leu Ile Lys Ala Leu Ile Asp 
                245                 250                 255     


Gln Gly Tyr Val Lys Gln Ile Leu Val Ser Asn Asp Trp Leu Phe Gly 
            260                 265                 270         


Phe Ser Ser Trp Val Thr Asn Ile Met Asp Val Met Asp Ser Val Asn 
        275                 280                 285             


Pro Asp Gly Met Ala Phe Ile Pro Leu Arg Val Ile Pro Phe Leu Arg 
    290                 295                 300                 


Glu Lys Gly Val Pro Gln Glu Thr Leu Ala Thr Ile Thr Val Glu Asn 
305                 310                 315                 320 


Pro Ala Arg Phe Leu Ser Pro Thr Leu Arg Ala Ser 
                325                 330         


