                         SEQUENCE LISTING

<110>  The National Institute for Biotechnology in the Negev Ltd.
       Yissum Research Development Company of the Hebrew 
       University
 
<120>  MATRIX METALLOPROTEINASE INHIBITORS AND METHODS OF USE THEREOF

<130>  3145/1.2

<150>  US 62419497
<151>  2016-11-09

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is R, A, M, E, P, or S

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is V, R, or G

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  X is L, M, I, V, or P

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  X is N, D, Q, or P

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  X is D, G, S, or N

<220>
<221>  MISC_FEATURE
<222>  (71)..(71)
<223>  X is V, I, A, G, or N

<220>
<221>  MISC_FEATURE
<222>  (97)..(97)
<223>  X is H, R or L

<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  X is I or T

<220>
<221>  MISC_FEATURE
<222>  (99)..(99)
<223>  X is S, N, or T

<220>
<221>  MISC_FEATURE
<222>  (116)..(116)
<223>  X is K or E

<400>  1

Cys Ser Cys Xaa Pro Xaa His Pro Gln Gln Ala Phe Cys Asn Ala Asp 
1               5                   10                  15      


Val Val Ile Arg Ala Lys Ala Val Ser Glu Lys Glu Val Asp Ser Gly 
            20                  25                  30          


Asn Asp Xaa Tyr Gly Xaa Pro Ile Lys Arg Ile Gln Tyr Glu Ile Lys 
        35                  40                  45              


Gln Ile Lys Met Phe Lys Gly Pro Glu Lys Asp Ile Glu Phe Ile Tyr 
    50                  55                  60                  


Thr Ala Pro Xaa Ser Ala Xaa Cys Gly Val Ser Leu Asp Val Gly Gly 
65                  70                  75                  80  


Lys Lys Glu Tyr Leu Ile Ala Gly Lys Ala Glu Gly Asp Gly Lys Met 
                85                  90                  95      


Xaa Xaa Xaa Leu Cys Asp Phe Ile Val Pro Trp Asp Thr Leu Ser Thr 
            100                 105                 110         


Thr Gln Lys Xaa Ser Leu Asn His Arg Tyr Gln Met Gly Cys Glu 
        115                 120                 125         


<210>  2
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Cys Ser Cys Ala Pro Val His Pro Gln Gln Ala Phe Cys Asn Ala Asp 
1               5                   10                  15      


Val Val Ile Arg Ala Lys Ala Val Ser Glu Lys Glu Val Asp Ser Gly 
            20                  25                  30          


Asn Asp Pro Tyr Gly Asp Pro Ile Lys Arg Ile Gln Tyr Glu Ile Lys 
        35                  40                  45              


Gln Ile Lys Met Phe Lys Gly Pro Glu Lys Asp Ile Glu Phe Ile Tyr 
    50                  55                  60                  


Thr Ala Pro Asp Ser Ala Ile Cys Gly Val Ser Leu Asp Val Gly Gly 
65                  70                  75                  80  


Lys Lys Glu Tyr Leu Ile Ala Gly Lys Ala Glu Gly Asp Gly Lys Met 
                85                  90                  95      


Arg Ile Ser Leu Cys Asp Phe Ile Val Pro Trp Asp Thr Leu Ser Thr 
            100                 105                 110         


Thr Gln Lys Lys Ser Leu Asn His Arg Tyr Gln Met Gly Cys Glu 
        115                 120                 125         


<210>  3
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  3
tgcagctgcg cgccggtgca cccgcaacag gcgttttgca atgcagatgt agtgatcagg       60

gccaaagcgg tcagtgagaa ggaagtggac tctggaaacg acccgtatgg cgaccctatc      120

aagaggatcc agtatgagat caagcagata aagatgttca aagggcctga gaaggatata      180

gagtttatct acacggcccc cgattcggca atttgtgggg tctcgctgga cgttggagga      240

aagaaggaat atctcattgc aggaaaggcc gagggggacg gcaagatgcg catcagcctc      300

tgtgacttca tcgtgccctg ggacaccctg agcaccaccc agaagaagag cctgaaccac      360

aggtaccaga tgggctgcga g                                                381


<210>  4
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  4

Cys Ser Cys Arg Pro Val His Pro Gln Gln Ala Phe Cys Asn Ala Asp 
1               5                   10                  15      


Val Val Ile Arg Ala Lys Ala Val Ser Glu Lys Glu Val Asp Ser Gly 
            20                  25                  30          


Asn Asp Leu Tyr Gly Asp Pro Ile Lys Arg Ile Gln Tyr Glu Ile Lys 
        35                  40                  45              


Gln Ile Lys Met Phe Lys Gly Pro Glu Lys Asp Ile Glu Phe Ile Tyr 
    50                  55                  60                  


Thr Ala Pro Asp Ser Ala Ile Cys Gly Val Ser Leu Asp Val Gly Gly 
65                  70                  75                  80  


Lys Lys Glu Tyr Leu Ile Ala Gly Lys Ala Glu Gly Asp Gly Lys Met 
                85                  90                  95      


Arg Ile Ser Leu Cys Asp Phe Ile Val Pro Trp Asp Thr Leu Ser Thr 
            100                 105                 110         


Thr Gln Lys Lys Ser Leu Asn His Arg Tyr Gln Met Gly Cys Glu 
        115                 120                 125         


<210>  5
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  5
tgcagctgca ggccggtgca cccgcaacag gcgttttgca atgcagatgt agtgatcagg       60

gccaaagcgg tcagtgagaa ggaagtggac tctggaaacg acctctatgg cgaccctatc      120

aagaggatcc agtatgagat caagcagata aagatgttca aagggcctga gaaggatata      180

gagtttatct acacggcccc cgattcggca atttgtgggg tctcgctgga cgttggagga      240

aagaaggaat atctcattgc aggaaaggcc gagggggacg gcaagatgcg catcagcctc      300

tgtgacttca tcgtgccctg ggacaccctg agcaccaccc agaagaagag cctgaaccac      360

aggtaccaga tgggctgcga g                                                381


<210>  6
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  6

Cys Ser Cys Met Pro Val His Pro Gln Gln Ala Phe Cys Asn Ala Asp 
1               5                   10                  15      


Val Val Ile Arg Ala Lys Ala Val Ser Glu Lys Glu Val Asp Ser Gly 
            20                  25                  30          


Asn Asp Met Tyr Gly Asp Pro Ile Lys Arg Ile Gln Tyr Glu Ile Lys 
        35                  40                  45              


Gln Ile Lys Met Phe Lys Gly Pro Glu Lys Asp Ile Glu Phe Ile Tyr 
    50                  55                  60                  


Thr Ala Pro Asn Ser Ala Gly Cys Gly Val Ser Leu Asp Val Gly Gly 
65                  70                  75                  80  


Lys Lys Glu Tyr Leu Ile Ala Gly Lys Ala Glu Gly Asp Gly Lys Met 
                85                  90                  95      


Leu Ile Thr Leu Cys Asp Phe Ile Val Pro Trp Asp Thr Leu Ser Thr 
            100                 105                 110         


Thr Gln Lys Lys Ser Leu Asn His Arg Tyr Gln Met Gly Cys Glu 
        115                 120                 125         


<210>  7
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  7
tgcagctgca tgccggtgca cccgcaacag gcgttttgca atgcagatgt agtgatcagg       60

gccaaagcgg tcagtgagaa ggaagtggac tctggaaacg acatgtatgg cgaccctatc      120

aagaggatcc agtatgagat caagcagata aagatgttca aagggcctga gaaggatata      180

gagtttatct acacggcccc caattcggca ggttgtgggg tctcgctgga cgttggagga      240

aagaaggaat atctcattgc aggaaaggcc gagggggacg gcaagatgtt gatcacgctc      300

tgtgacttca tcgtgccctg ggacaccctg agcaccaccc agaaggagag cctgaaccac      360

aggtaccaga tgggctgcga g                                                381


<210>  8
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  8

Cys Ser Cys Ser Pro Val His Pro Gln Gln Ala Phe Cys Asn Ala Asp 
1               5                   10                  15      


Val Val Ile Arg Ala Lys Ala Val Ser Glu Lys Glu Val Asp Ser Gly 
            20                  25                  30          


Asn Asp Met Tyr Gly Asp Pro Ile Lys Arg Ile Gln Tyr Glu Ile Lys 
        35                  40                  45              


Gln Ile Lys Met Phe Lys Gly Pro Glu Lys Asp Ile Glu Phe Ile Tyr 
    50                  55                  60                  


Thr Ala Pro Asn Ser Ala Gly Cys Gly Val Ser Leu Asp Val Gly Gly 
65                  70                  75                  80  


Lys Lys Glu Tyr Leu Ile Ala Gly Lys Ala Glu Gly Asp Gly Lys Met 
                85                  90                  95      


Arg Ile Thr Leu Cys Asp Phe Ile Val Pro Trp Asp Thr Leu Ser Thr 
            100                 105                 110         


Thr Gln Lys Lys Ser Leu Asn His Arg Tyr Gln Met Gly Cys Glu 
        115                 120                 125         


<210>  9
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  9
tgcagctgct cgccggtgca cccgcaacag gcgttttgca atgcagatgt agtgatcagg       60

gccaaagcgg tcagtgagaa ggaagtggac tctggaaacg acatgtatgg cgaccctatc      120

aagaggatcc agtatgagat caagcagata aagatgttca aagggcctga gaaggatata      180

gagtttatct acacggcccc aaattcggca ggttgtgggg tctcgctgga cgttggagga      240

aagaaggaat atctcattgc aggaaaggcc gagggggacg gcaagatgag gatcacgctc      300

tgtgacttca tcgtgccctg ggacaccctg agcaccaccc agaagaagag cctgaaccac      360

aggtaccaga tgggctgcga g                                                381


<210>  10
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  10
ggtggttctg gtggtggtgg ttctggtggt ggtggttctg ctagctgcag ctgctccccg       60

gtg                                                                     63


<210>  11
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  11

Cys Ser Cys Ser Pro Val His Pro Gln Gln Ala Phe Cys Asn Ala Asp 
1               5                   10                  15      


Val Val Ile Arg Ala Lys Ala Val Ser Glu Lys Glu Val Asp Ser Gly 
            20                  25                  30          


Asn Asp Ile Tyr Gly Asn Pro Ile Lys Arg Ile Gln Tyr Glu Ile Lys 
        35                  40                  45              


Gln Ile Lys Met Phe Lys Gly Pro Glu Lys Asp Ile Glu Phe Ile Tyr 
    50                  55                  60                  


Thr Ala Pro Ser Ser Ala Val Cys Gly Val Ser Leu Asp Val Gly Gly 
65                  70                  75                  80  


Lys Lys Glu Tyr Leu Ile Ala Gly Lys Ala Glu Gly Asp Gly Lys Met 
                85                  90                  95      


His Ile Thr Leu Cys Asp Phe Ile Val Pro Trp Asp Thr Leu Ser Thr 
            100                 105                 110         


Thr Gln Lys Lys Ser Leu Asn His Arg Tyr Gln Met Gly Cys Glu 
        115                 120                 125         


<210>  12
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  12
gctattacaa gtcctcttca gaaataagct tttgttcaga tggatcttgg aaagccaatg       60

gtttatctgg caaggatccc tcgcagccca tctggtac                               98


<210>  13
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  13
cttgttggct atcttcgctg ctttgccatt ggccttagct tgcagctgct ccccggtg         58


<210>  14
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  14
gtcttcttcg gagataagct tttgttctgc acgcgtggat ccctcgcagc ccatctggta       60

cc                                                                      62


<210>  15
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  15
ccggttattt ctactaccgt cggttc                                            26


<210>  16
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  16
gtcagttcct gcaagtcttc ttcg                                              24


<210>  17
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  17
ggtatctctc gagaaaagat gcagctgctc cccg                                   34


<210>  18
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  18
ggtatctctc gagaaaagat gcagctgcgc gccg                                   34


<210>  19
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  19
ggtatctctc gagaaaagat gcagctgcag gccg                                   34


<210>  20
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  20
ggtatctctc gagaaaagat gcagctgcat gccg                                   34


<210>  21
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  21
ggtatctctc gagaaaagat gcagctgctc gccg                                   34


<210>  22
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  22
gctggcggcc gcctcgcagc ccatctggta                                        30


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X= 7-methoxycoumarin-4-yl acetic acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= 9,10-diphenylanthracene

<400>  23

Xaa Lys Pro Leu Gly Leu Xaa Ala Arg 
1               5                   


<210>  24
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  24

Cys Ser Cys Glu Pro Val His Pro Gln Gln Ala Phe Cys Asn Ala Asp 
1               5                   10                  15      


Val Val Ile Arg Ala Lys Ala Val Ser Glu Lys Glu Val Asp Ser Gly 
            20                  25                  30          


Asn Asp Ile Tyr Gly Gln Pro Ile Lys Arg Ile Gln Tyr Glu Ile Lys 
        35                  40                  45              


Gln Ile Lys Met Phe Lys Gly Pro Glu Lys Asp Ile Glu Phe Ile Tyr 
    50                  55                  60                  


Thr Ala Pro Ser Ser Ala Asn Cys Gly Val Ser Leu Asp Val Gly Gly 
65                  70                  75                  80  


Lys Lys Glu Tyr Leu Ile Ala Gly Lys Ala Glu Gly Asp Gly Lys Met 
                85                  90                  95      


Arg Ile Ser Leu Cys Asp Phe Ile Val Pro Trp Asp Thr Leu Ser Thr 
            100                 105                 110         


Thr Gln Lys Lys Ser Leu Asn His Arg Tyr Gln Met Gly Cys Glu 
        115                 120                 125         


<210>  25
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  25

Cys Ser Cys Glu Pro Arg His Pro Gln Gln Ala Phe Cys Asn Ala Asp 
1               5                   10                  15      


Val Met Ile Arg Ala Lys Ala Val Ser Glu Lys Glu Val Asp Ser Gly 
            20                  25                  30          


Asn Asp Val Tyr Gly Gln Pro Ile Lys Arg Ile Gln Tyr Glu Ile Lys 
        35                  40                  45              


Gln Ile Lys Met Phe Lys Gly Pro Glu Lys Asp Ile Glu Phe Ile Tyr 
    50                  55                  60                  


Thr Ala Pro Asn Ser Ala Asn Cys Gly Val Ser Leu Asp Val Gly Gly 
65                  70                  75                  80  


Lys Lys Glu Tyr Leu Ile Ala Gly Lys Ala Glu Gly Asp Gly Lys Met 
                85                  90                  95      


Arg Ile Ser Leu Cys Asp Phe Ile Val Pro Trp Asp Thr Leu Ser Thr 
            100                 105                 110         


Thr Gln Lys Lys Ser Leu Asn His Arg Tyr Gln Met Gly Cys Glu 
        115                 120                 125         


<210>  26
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  26

Cys Ser Cys Pro Pro Val His Pro Gln Gln Ala Phe Cys Asn Ala Asp 
1               5                   10                  15      


Val Val Ile Arg Ala Lys Ala Val Ser Glu Lys Glu Val Asp Ser Gly 
            20                  25                  30          


Asn Asp Val Tyr Gly Asn Pro Ile Lys Arg Ile Gln Tyr Glu Ile Lys 
        35                  40                  45              


Gln Ile Lys Met Phe Lys Gly Pro Glu Lys Asp Ile Glu Phe Ile Tyr 
    50                  55                  60                  


Thr Ala Pro Asn Ser Ala Ile Cys Gly Val Ser Leu Asp Val Gly Gly 
65                  70                  75                  80  


Lys Lys Glu Tyr Leu Ile Ala Gly Lys Ala Glu Gly Asp Gly Lys Met 
                85                  90                  95      


Arg Ile Thr Leu Cys Asp Phe Ile Val Pro Trp Asp Thr Leu Ser Thr 
            100                 105                 110         


Thr Gln Lys Lys Ser Leu Asn His Arg Tyr Gln Met Gly Cys Glu 
        115                 120                 125         


<210>  27
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  27

Cys Ser Cys Pro Pro Gly His Pro Gln Gln Ala Phe Cys Asn Ala Asp 
1               5                   10                  15      


Val Val Ile Arg Ala Lys Ala Val Ser Glu Lys Glu Val Asp Ser Gly 
            20                  25                  30          


Asn Asp Val Tyr Gly Asn Pro Ile Lys Arg Ile Gln Tyr Glu Ile Lys 
        35                  40                  45              


Gln Ile Lys Met Phe Lys Gly Pro Glu Lys Asp Ile Glu Phe Ile Tyr 
    50                  55                  60                  


Thr Ala Pro Asn Ser Ala Ile Cys Gly Val Ser Leu Asp Val Gly Gly 
65                  70                  75                  80  


Lys Lys Glu Tyr Leu Ile Ala Gly Lys Ala Glu Gly Asp Gly Lys Met 
                85                  90                  95      


His Ile Asn Leu Cys Asp Phe Ile Val Pro Trp Asp Thr Leu Ser Thr 
            100                 105                 110         


Thr Gln Lys Lys Ser Leu Asn His Arg Tyr Gln Met Gly Cys Glu 
        115                 120                 125         


<210>  28
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  b =  g or c or t

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  m =  a or c

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  r =  g or a

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  s =  g or c

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  k =  g or t

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  n is a, c, g, or t

<400>  28
taccgtcggt tccgctgcag aaggctcttt ggacaagaga tgcagctgcb mrccgsknca       60

cccgcaacag gcgttttgca atgcagatgt agtgatcagg gccaaagcgg tcagtgagaa      120

ggaagtggac tctgg                                                       135


<210>  29
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  r =  g or a

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  w =  a or t

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  m =  a or c

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  n is a, c, g, or t

<400>  29
gagaaggaag tggactctgg aaacgacrwa tatggcmanc ctatcaagag gatccagtat       60

gagatcaagc agataaagat gttcaaaggg cctgagaagg atatagag                   108


<210>  30
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  r = g or a

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  w =  a or t

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  y =  t or c

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  s =  g or c

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  y =  t or c

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  w =  a or t

<400>  30
ctttcctgca atgagatatt ccttctttcc tccaacgtcc agcgagaccc cacarwytgc       60

cgasywgggg gccgtgtaga taaactctat atccttctca ggccct                     106


<210>  31
<211>  139
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  r= g or a

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  k= g or t

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  w= a or t

<220>
<221>  misc_feature
<222>  (91)..(91)
<223>  r = g or a

<220>
<221>  misc_feature
<222>  (92)..(92)
<223>  y = t or c

<400>  31
ctcgcagccc atctggtacc tgtggttcag gctcttcttc tgggtggtgc tcagggtgtc       60

ccagggcacg atgaagtcac agagrkwgat rygcatcttg ccgtccccct cggcctttcc      120

tgcaatgaga tattccttc                                                   139


<210>  32
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  32
taccgtcggt tccgctgc                                                     18


<210>  33
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  33
ggtaattaat cagcgaagcg atg                                               23


<210>  34
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  34
gctgcctttg ctagttgttg ag                                                22


<210>  35
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  35
gctgctaaag aagaaggggt atctctcgag aaaagatgca gctgcgagcc gg               52


<210>  36
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  36
gctgctaaag aagaaggggt atctctcgag aaaagatgca gctgcgagcc gc               52


<210>  37
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  37
gctgctaaag aagaaggggt atctctcgag aaaagatgca gctgcccgcc g                51


<210>  38
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  38
gctgctaaag aagaaggggt atctctcgag aaaagatgca gctgctcccc gg               52


<210>  39
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  39
gagtttttgt tctagaaagc tggcggccgc ctcgcagccc atctggtacc                  50


<210>  40
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  40
gactggttcc aattgaca                                                     18


<210>  41
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  41
cccctctaga aataattttg tttaacttta agaaggagat atacattatg tgcagctgcg       60

agccg                                                                   65


<210>  42
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  42
cccctctaga aataattttg tttaacttta agaaggagat atacattatg tgcagctgcg       60

agccgc                                                                  66


<210>  43
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  43
cccctctaga aataattttg tttaacttta agaaggagat atacattatg tgcagctgcc       60

cgccg                                                                   65


<210>  44
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  44
cccctctaga aataattttg tttaacttta agaaggagat atacattatg tgcagctgcc       60

cgccg                                                                   65


<210>  45
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  45
cccctctaga aataattttg tttaacttta agaaggagat atacattatg tgcagctgct       60

ccccgg                                                                  66


<210>  46
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  46
gatcaagctt cgaattctta ttaatgatga tgatgatgat gatgctcgca gcccatctgg       60


<210>  47
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  47

Cys Ser Cys Ser Pro Val His Pro Gln Gln Ala Phe Cys Asn Ala Asp 
1               5                   10                  15      


Val Val Ile Arg Ala Lys Ala Val Ser Glu Lys Glu Val Asp Ser Gly 
            20                  25                  30          


Asn Asp Ile Tyr Gly Asn Pro Ile Lys Arg Ile Gln Tyr Glu Ile Lys 
        35                  40                  45              


Gln Ile Lys Met Phe Lys Gly Pro Glu Lys Asp Ile Glu Phe Ile Tyr 
    50                  55                  60                  


Thr Ala Pro Ser Ser Ala Ala Cys Gly Val Ser Leu Asp Val Gly Gly 
65                  70                  75                  80  


Lys Lys Glu Tyr Leu Ile Ala Gly Lys Ala Glu Gly Asp Gly Lys Met 
                85                  90                  95      


His Thr Thr Leu Cys Asp Phe Ile Val Pro Trp Asp Thr Leu Ser Thr 
            100                 105                 110         


Thr Gln Lys Glu Ser Leu Asn His Arg Tyr Gln Met Gly Cys Glu 
        115                 120                 125         


