                         SEQUENCE LISTING

<110>  Beijing Biocytogen Co., Ltd
 
<120>  Genetically modified non-human animal with human or chimeric LAG-3

<130>  1

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  23
<212>  DNA
<213>  Artificial Sequence

<400>  1
gttccactag ttgtgtcttc agg                                               23


<210>  2
<211>  23
<212>  DNA
<213>  Artificial Sequence

<400>  2
ggccctgaag acacaactag tgg                                               23


<210>  3
<211>  23
<212>  DNA
<213>  Artificial Sequence

<400>  3
accacgggga gctctttccc agg                                               23


<210>  4
<211>  23
<212>  DNA
<213>  Artificial Sequence

<400>  4
ctagttgtgt cttcagggcc tgg                                               23


<210>  5
<211>  23
<212>  DNA
<213>  Artificial Sequence

<400>  5
gcctgggaaa gagctccccg tgg                                               23


<210>  6
<211>  23
<212>  DNA
<213>  Artificial Sequence

<400>  6
cctcctgggc ccacaccacg ggg                                               23


<210>  7
<211>  23
<212>  DNA
<213> Artificial Sequence

<400>  7
ggaaagagct ccccgtggtg tgg                                               23


<210>  8
<211>  23
<212>  DNA
<213>  Artificial Sequence

<400>  8
tcgaggcctg gccgacgcgc agg                                               23


<210>  9
<211>  23
<212>  DNA
<213>  Artificial Sequence

<400>  9
tctccgcctg cgcgtcggcc agg                                               23


<210>  10
<211>  23
<212>  DNA
<213>  Artificial Sequence

<400>  10
aggcctggcc gacgcgcagg cgg                                               23


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<400>  11
tgcagtctcc gcctgcgcgt cgg                                               23


<210>  12
<211>  23
<212>  DNA
<213>  Artificial Sequence

<400>  12
aggagagggc gcggttcggg agg                                               23


<210>  13
<211>  23
<212>  DNA
<213>  Artificial Sequence

<400>  13
gcggttcggg aggcgcacgg tgg                                               23


<210>  14
<211>  23
<212>  DNA
<213>  Artificial Sequence

<400>  14
tgcaggagag ggcgcggttc ggg                                               23


<210>  15
<211>  19
<212>  DNA
<213>  Artificial Sequence

<400>  15
cctgggaaag agctccccg                                                    19


<210>  16
<211>  23
<212>  DNA
<213>  Artificial Sequence

<400>  16
taggcctggg aaagagctcc ccg                                               23


<210>  17
<211>  19
<212>  DNA
<213>  Artificial Sequence

<400>  17
cggggagctc tttcccagg                                                    19


<210>  18
<211>  23
<212>  DNA
<213>  Artificial Sequence

<400>  18
aaaccgggga gctctttccc agg                                               23


<210>  19
<211>  17
<212>  DNA
<213>  Artificial Sequence

<400>  19
agagggcgcg gttcggg                                                      17


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<400>  20
taggagaggg cgcggttcgg g                                                 21


<210>  21
<211>  17
<212>  DNA
<213>  Artificial Sequence

<400>  21
cccgaaccgc gccctct                                                      17


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<400>  22
aaaccccgaa ccgcgccctc t                                                 21


<210>  23
<211>  132
<212>  DNA
<213>  Artificial Sequence

<400>  23
gaattctaat acgactcact atagggggtc ttcgagaaga cctgttttag agctagaaat       60

agcaagttaa aataaggcta gtccgttatc aacttgaaaa agtggcaccg agtcggtgct      120

tttaaaggat cc                                                          132


<210>  24
<211>  2020
<212>  DNA/RNA
<213>  Mouse

<400>  24
gggcagtggg gaggagaagc agaaggactg ggtctggagg agcagctcaa gttctagcta       60

gctgcagtgg gtttgcctgc actctgctct gggtcccagc ccgggcctct gatcattatc      120

catcctgctg tctccagtcc ccactcctgg ggcgtcctct tcaccctaca ttctttccct      180

ccgcctcacc tcctccttgt agaacttctc tctctctctc tctctctctc tctctctctc      240

tctctctctc tctgtgtgtg tgtgtgtgtc tgtctgtctg tctgtctctc tctcctccca      300

ggaccttttt ctaacctccc ttggagggct ggggaggccc gggccataga ggagatgagg      360

gaggacctgc tccttggctt tttgcttctg ggactgcttt gggaagctcc agttgtgtct      420

tcagggcctg ggaaagagct ccccgtggtg tgggcccagg agggagctcc cgtccatctt      480

ccctgcagcc tcaaatcccc caacctggat cctaactttc tacgaagagg aggggttatc      540

tggcaacatc aaccagacag tggccaaccc actcccatcc cggcccttga ccttcaccag      600

gggatgccct cgcctagaca acccgcaccc ggtcgctaca cggtgctgag cgtggctcca      660

ggaggcctgc gcagcgggag gcagcccctg catccccacg tgcagctgga ggagcgcggc      720

ctccagcgcg gggacttctc tctgtggttg cgcccagctc tgcgcaccga tgcgggcgag      780

taccacgcca ccgtgcgcct cccgaaccgc gccctctcct gcagtctccg cctgcgcgtc      840

ggccaggcct cgatgattgc tagtccctca ggagtcctca agctgtctga ttgggtcctt      900

ttgaactgct ccttcagccg tcctgaccgc ccagtctctg tgcactggtt ccagggccag      960

aaccgagtgc ctgtctacaa ctcaccgcgt cattttttag ctgaaacttt cctgttactg     1020

ccccaagtca gccccctgga ctctgggacc tggggctgtg tcctcaccta cagagatggc     1080

ttcaatgtct ccatcacgta caacctcaag gttctgggtc tggagcccgt agcccctctg     1140

acagtgtacg ctgctgaagg ttctagggtg gagctgccct gtcatttgcc cccaggagtg     1200

gggacccctt ctttgctcat tgccaagtgg actcctcctg gaggaggtcc tgagctcccc     1260

gtggctggaa agagtggcaa ttttaccctt caccttgagg ctgtgggtct ggcacaggct     1320

gggacctaca cctgtagcat ccatctgcag ggacagcagc tcaatgccac tgtcacgttg     1380

gcggtcatca cagtgactcc caaatccttc gggttacctg gctcccgggg gaagctgttg     1440

tgtgaggtaa ccccggcatc tggaaaggaa agatttgtgt ggcgtcccct gaacaatctg     1500

tccaggagtt gcccgggccc tgtgctggag attcaggagg ccaggctcct tgctgagcga     1560

tggcagtgtc agctgtacga gggccagagg cttcttggag cgacagtgta cgccgcagag     1620

tctagctcag gcgcccacag tgctaggaga atctcaggtg accttaaagg aggccatctc     1680

gttctcgttc tcatccttgg tgccctctcc ctgttccttt tggtggccgg ggcctttggc     1740

tttcactggt ggagaaaaca gttgctactg agaagatttt ctgccttaga acatgggatt     1800

cagccatttc cggctcagag gaagatagag gagctggagc gagaactgga gacggagatg     1860

ggacaggagc cggagcccga gccggagcca cagctggagc cagagcccag gcagctctga     1920

cctggagccg aggcagccag caggtctcag cagctccgcc cgcccgcccg cccgcccgaa     1980

taaactccct gtcagcagca tcaaaaaaaa aaaaaaaaaa                           2020


<210>  25
<211>  521
<212>  PRT
<213>  Mouse

<400>  25

Met Arg Glu Asp Leu Leu Leu Gly Phe Leu Leu Leu Gly Leu Leu Trp 
1               5                   10                  15      


Glu Ala Pro Val Val Ser Ser Gly Pro Gly Lys Glu Leu Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Val His Leu Pro Cys Ser Leu Lys Ser 
        35                  40                  45              


Pro Asn Leu Asp Pro Asn Phe Leu Arg Arg Gly Gly Val Ile Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Gln Pro Thr Pro Ile Pro Ala Leu Asp Leu 
65                  70                  75                  80  


His Gln Gly Met Pro Ser Pro Arg Gln Pro Ala Pro Gly Arg Tyr Thr 
                85                  90                  95      


Val Leu Ser Val Ala Pro Gly Gly Leu Arg Ser Gly Arg Gln Pro Leu 
            100                 105                 110         


His Pro His Val Gln Leu Glu Glu Arg Gly Leu Gln Arg Gly Asp Phe 
        115                 120                 125             


Ser Leu Trp Leu Arg Pro Ala Leu Arg Thr Asp Ala Gly Glu Tyr His 
    130                 135                 140                 


Ala Thr Val Arg Leu Pro Asn Arg Ala Leu Ser Cys Ser Leu Arg Leu 
145                 150                 155                 160 


Arg Val Gly Gln Ala Ser Met Ile Ala Ser Pro Ser Gly Val Leu Lys 
                165                 170                 175     


Leu Ser Asp Trp Val Leu Leu Asn Cys Ser Phe Ser Arg Pro Asp Arg 
            180                 185                 190         


Pro Val Ser Val His Trp Phe Gln Gly Gln Asn Arg Val Pro Val Tyr 
        195                 200                 205             


Asn Ser Pro Arg His Phe Leu Ala Glu Thr Phe Leu Leu Leu Pro Gln 
    210                 215                 220                 


Val Ser Pro Leu Asp Ser Gly Thr Trp Gly Cys Val Leu Thr Tyr Arg 
225                 230                 235                 240 


Asp Gly Phe Asn Val Ser Ile Thr Tyr Asn Leu Lys Val Leu Gly Leu 
                245                 250                 255     


Glu Pro Val Ala Pro Leu Thr Val Tyr Ala Ala Glu Gly Ser Arg Val 
            260                 265                 270         


Glu Leu Pro Cys His Leu Pro Pro Gly Val Gly Thr Pro Ser Leu Leu 
        275                 280                 285             


Ile Ala Lys Trp Thr Pro Pro Gly Gly Gly Pro Glu Leu Pro Val Ala 
    290                 295                 300                 


Gly Lys Ser Gly Asn Phe Thr Leu His Leu Glu Ala Val Gly Leu Ala 
305                 310                 315                 320 


Gln Ala Gly Thr Tyr Thr Cys Ser Ile His Leu Gln Gly Gln Gln Leu 
                325                 330                 335     


Asn Ala Thr Val Thr Leu Ala Val Ile Thr Val Thr Pro Lys Ser Phe 
            340                 345                 350         


Gly Leu Pro Gly Ser Arg Gly Lys Leu Leu Cys Glu Val Thr Pro Ala 
        355                 360                 365             


Ser Gly Lys Glu Arg Phe Val Trp Arg Pro Leu Asn Asn Leu Ser Arg 
    370                 375                 380                 


Ser Cys Pro Gly Pro Val Leu Glu Ile Gln Glu Ala Arg Leu Leu Ala 
385                 390                 395                 400 


Glu Arg Trp Gln Cys Gln Leu Tyr Glu Gly Gln Arg Leu Leu Gly Ala 
                405                 410                 415     


Thr Val Tyr Ala Ala Glu Ser Ser Ser Gly Ala His Ser Ala Arg Arg 
            420                 425                 430         


Ile Ser Gly Asp Leu Lys Gly Gly His Leu Val Leu Val Leu Ile Leu 
        435                 440                 445             


Gly Ala Leu Ser Leu Phe Leu Leu Val Ala Gly Ala Phe Gly Phe His 
    450                 455                 460                 


Trp Trp Arg Lys Gln Leu Leu Leu Arg Arg Phe Ser Ala Leu Glu His 
465                 470                 475                 480 


Gly Ile Gln Pro Phe Pro Ala Gln Arg Lys Ile Glu Glu Leu Glu Arg 
                485                 490                 495     


Glu Leu Glu Thr Glu Met Gly Gln Glu Pro Glu Pro Glu Pro Glu Pro 
            500                 505                 510         


Gln Leu Glu Pro Glu Pro Arg Gln Leu 
        515                 520     


<210>  26
<211>  1995
<212>  DNA/RNA
<213>  human

<400>  26
acaggggtga aggcccagag accagcagaa cggcatccca gccacgacgg ccactttgct       60

ctgtctgctc tccgccacgg ccctgctctg ttccctggga cacccccgcc cccacctcct      120

caggctgcct gatctgccca gctttccagc tttcctctgg attccggcct ctggtcatcc      180

ctccccaccc tctctccaag gccctctcct ggtctccctt cttctagaac cccttcctcc      240

acctccctct ctgcagaact tctcctttac cccccacccc ccaccactgc cccctttcct      300

tttctgacct ccttttggag ggctcagcgc tgcccagacc ataggagaga tgtgggaggc      360

tcagttcctg ggcttgctgt ttctgcagcc gctttgggtg gctccagtga agcctctcca      420

gccaggggct gaggtcccgg tggtgtgggc ccaggagggg gctcctgccc agctcccctg      480

cagccccaca atccccctcc aggatctcag ccttctgcga agagcagggg tcacttggca      540

gcatcagcca gacagtggcc cgcccgctgc cgcccccggc catcccctgg cccccggccc      600

tcacccggcg gcgccctcct cctgggggcc caggccccgc cgctacacgg tgctgagcgt      660

gggtcccgga ggcctgcgca gcgggaggct gcccctgcag ccccgcgtcc agctggatga      720

gcgcggccgg cagcgcgggg acttctcgct atggctgcgc ccagcccggc gcgcggacgc      780

cggcgagtac cgcgccgcgg tgcacctcag ggaccgcgcc ctctcctgcc gcctccgtct      840

gcgcctgggc caggcctcga tgactgccag ccccccagga tctctcagag cctccgactg      900

ggtcattttg aactgctcct tcagccgccc tgaccgccca gcctctgtgc attggttccg      960

gaaccggggc cagggccgag tccctgtccg ggagtccccc catcaccact tagcggaaag     1020

cttcctcttc ctgccccaag tcagccccat ggactctggg ccctggggct gcatcctcac     1080

ctacagagat ggcttcaacg tctccatcat gtataacctc actgttctgg gtctggagcc     1140

cccaactccc ttgacagtgt acgctggagc aggttccagg gtggggctgc cctgccgcct     1200

gcctgctggt gtggggaccc ggtctttcct cactgccaag tggactcctc ctgggggagg     1260

ccctgacctc ctggtgactg gagacaatgg cgactttacc cttcgactag aggatgtgag     1320

ccaggcccag gctgggacct acacctgcca tatccatctg caggaacagc agctcaatgc     1380

cactgtcaca ttggcaatca tcacagtgac tcccaaatcc tttgggtcac ctggatccct     1440

ggggaagctg ctttgtgagg tgactccagt atctggacaa gaacgctttg tgtggagctc     1500

tctggacacc ccatcccaga ggagtttctc aggaccttgg ctggaggcac aggaggccca     1560

gctcctttcc cagccttggc aatgccagct gtaccagggg gagaggcttc ttggagcagc     1620

agtgtacttc acagagctgt ctagcccagg tgcccaacgc tctgggagag ccccaggtgc     1680

cctcccagca ggccacctcc tgctgtttct catccttggt gtcctttctc tgctcctttt     1740

ggtgactgga gcctttggct ttcacctttg gagaagacag tggcgaccaa gacgattttc     1800

tgccttagag caagggattc accctccgca ggctcagagc aagatagagg agctggagca     1860

agaaccggag ccggagccgg agccggaacc ggagcccgag cccgagcccg agccggagca     1920

gctctgacct ggagctgagg cagccagcag atctcagcag cccagtccaa ataaactccc     1980

tgtcagcagc aaaaa                                                      1995


<210>  27
<211>  525
<212>  PRT
<213>  human

<400>  27

Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp 
1               5                   10                  15      


Val Ala Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile 
        35                  40                  45              


Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu 
65                  70                  75                  80  


Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro 
                85                  90                  95      


Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly 
            100                 105                 110         


Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln 
        115                 120                 125             


Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala 
    130                 135                 140                 


Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys 
145                 150                 155                 160 


Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro 
                165                 170                 175     


Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser 
            180                 185                 190         


Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln 
        195                 200                 205             


Gly Arg Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser 
    210                 215                 220                 


Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly 
225                 230                 235                 240 


Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn 
                245                 250                 255     


Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala 
            260                 265                 270         


Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val 
        275                 280                 285             


Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly 
    290                 295                 300                 


Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu 
305                 310                 315                 320 


Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His 
                325                 330                 335     


Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr 
            340                 345                 350         


Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu 
        355                 360                 365             


Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe Val Trp Ser Ser 
    370                 375                 380                 


Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala 
385                 390                 395                 400 


Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln 
                405                 410                 415     


Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser 
            420                 425                 430         


Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly 
        435                 440                 445             


His Leu Leu Leu Phe Leu Ile Leu Gly Val Leu Ser Leu Leu Leu Leu 
    450                 455                 460                 


Val Thr Gly Ala Phe Gly Phe His Leu Trp Arg Arg Gln Trp Arg Pro 
465                 470                 475                 480 


Arg Arg Phe Ser Ala Leu Glu Gln Gly Ile His Pro Pro Gln Ala Gln 
                485                 490                 495     


Ser Lys Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro Glu Pro Glu Pro 
            500                 505                 510         


Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln Leu 
        515                 520                 525 


<210>  28
<211>  810
<212>  DNA
<213>  Artificial Sequence

<400>  28
ttgtgtcttc agggccaggg gctgaggtcc cggtggtgtg ggcccaggag ggggctcctg       60

cccagctccc ctgcagcccc acaatccccc tccaggatct cagccttctg cgaagagcag      120

gggtcacttg gcagcatcag ccagacaggt atgcacccca aacttgggca acaggacctc      180

cgaatccagc actcaacccc acacccgtgc cggtcctctg tcccctgccc tgaggtgtca      240

ctccctctga agccagtgac ccagtctccc tgccctcgct tgcaccgttc ctgcccttgc      300

tctgcaatca gcgaccctca cgccagcatc ccttctctcc agaagtggat gcggccagtc      360

caacagaggg gtcgggcgtg aggggacggt tggtggtcaa gagaactctt ggggcgggct      420

ttctcatcct caacgggtgg ctgcctgcat cctcccgggc ttcctacccc tggagcttct      480

caactccatt ctctttcccg cccagtggcc cgcccgctgc cgcccccggc catcccctgg      540

cccccggccc tcacccggcg gcgccctcct cctgggggcc caggccccgc cgctacacgg      600

tgctgagcgt gggtcccgga ggcctgcgca gcgggaggct gcccctgcag ccccgcgtcc      660

agctggatga gcgcggccgg cagcgcgggg acttctcgct atggctgcgc ccagcccggc      720

gcgcggacgc cggcgagtac cgcgccgcgg tgcacctcag ggaccgcgcc ctctcctgcc      780

gcctccgtct gcgcctgggc caggcctcga                                       810


<210>  29
<211>  1578
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  29
atgagggagg acctgctcct tggctttttg cttctgggac tgctttggga agctccagtt       60

gtgtcttcag ggccaggggc tgaggtcccg gtggtgtggg cccaggaggg ggctcctgcc      120

cagctcccct gcagccccac aatccccctc caggatctca gccttctgcg aagagcaggg      180

gtcacttggc agcatcagcc agacagtggc ccgcccgctg ccgcccccgg ccatcccctg      240

gcccccggcc ctcacccggc ggcgccctcc tcctgggggc ccaggccccg ccgctacacg      300

gtgctgagcg tgggtcccgg aggcctgcgc agcgggaggc tgcccctgca gccccgcgtc      360

cagctggatg agcgcggccg gcagcgcggg gacttctcgc tatggctgcg cccagcccgg      420

cgcgcggacg ccggcgagta ccgcgccgcg gtgcacctca gggaccgcgc cctctcctgc      480

cgcctccgtc tgcgcctggg ccaggcctcg atgattgcta gtccctcagg agtcctcaag      540

ctgtctgatt gggtcctttt gaactgctcc ttcagccgtc ctgaccgccc agtctctgtg      600

cactggttcc agggccagaa ccgagtgcct gtctacaact caccgcgtca ttttttagct      660

gaaactttcc tgttactgcc ccaagtcagc cccctggact ctgggacctg gggctgtgtc      720

ctcacctaca gagatggctt caatgtctcc atcacgtaca acctcaaggt tctgggtctg      780

gagcccgtag cccctctgac agtgtacgct gctgaaggtt ctagggtgga gctgccctgt      840

catttgcccc caggagtggg gaccccttct ttgctcattg ccaagtggac tcctcctgga      900

ggaggtcctg agctccccgt ggctggaaag agtggcaatt ttacccttca ccttgaggct      960

gtgggtctgg cacaggctgg gacctacacc tgtagcatcc atctgcaggg acagcagctc     1020

aatgccactg tcacgttggc ggtcatcaca gtgactccca aatccttcgg gttacctggc     1080

tcccggggga agctgttgtg tgaggtaacc ccggcatctg gaaaggaaag atttgtgtgg     1140

cgtcccctga acaatctgtc caggagttgc ccgggccctg tgctggagat tcaggaggcc     1200

aggctccttg ctgagcgatg gcagtgtcag ctgtacgagg gccagaggct tcttggagcg     1260

acagtgtacg ccgcagagtc tagctcaggc gcccacagtg ctaggagaat ctcaggtgac     1320

cttaaaggag gccatctcgt tctcgttctc atccttggtg ccctctccct gttccttttg     1380

gtggccgggg cctttggctt tcactggtgg agaaaacagt tgctactgag aagattttct     1440

gccttagaac atgggattca gccatttccg gctcagagga agatagagga gctggagcga     1500

gaactggaga cggagatggg acaggagccg gagcccgagc cggagccaca gctggagcca     1560

gagcccaggc agctctga                                                   1578


<210>  30
<211>  2032
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  30
gggcagtggg gaggagaagc agaaggactg ggtctggagg agcagctcaa gttctagcta       60

gctgcagtgg gtttgcctgc actctgctct gggtcccagc ccgggcctct gatcattatc      120

catcctgctg tctccagtcc ccactcctgg ggcgtcctct tcaccctaca ttctttccct      180

ccgcctcacc tcctccttgt agaacttctc tctctctctc tctctctctc tctctctctc      240

tctctctctc tctgtgtgtg tgtgtgtgtc tgtctgtctg tctgtctctc tctcctccca      300

ggaccttttt ctaacctccc ttggagggct ggggaggccc gggccataga ggagatgagg      360

gaggacctgc tccttggctt tttgcttctg ggactgcttt gggaagctcc agttgtgtct      420

tcagggccag gggctgaggt cccggtggtg tgggcccagg agggggctcc tgcccagctc      480

ccctgcagcc ccacaatccc cctccaggat ctcagccttc tgcgaagagc aggggtcact      540

tggcagcatc agccagacag tggcccgccc gctgccgccc ccggccatcc cctggccccc      600

ggccctcacc cggcggcgcc ctcctcctgg gggcccaggc cccgccgcta cacggtgctg      660

agcgtgggtc ccggaggcct gcgcagcggg aggctgcccc tgcagccccg cgtccagctg      720

gatgagcgcg gccggcagcg cggggacttc tcgctatggc tgcgcccagc ccggcgcgcg      780

gacgccggcg agtaccgcgc cgcggtgcac ctcagggacc gcgccctctc ctgccgcctc      840

cgtctgcgcc tgggccaggc ctcgatgatt gctagtccct caggagtcct caagctgtct      900

gattgggtcc ttttgaactg ctccttcagc cgtcctgacc gcccagtctc tgtgcactgg      960

ttccagggcc agaaccgagt gcctgtctac aactcaccgc gtcatttttt agctgaaact     1020

ttcctgttac tgccccaagt cagccccctg gactctggga cctggggctg tgtcctcacc     1080

tacagagatg gcttcaatgt ctccatcacg tacaacctca aggttctggg tctggagccc     1140

gtagcccctc tgacagtgta cgctgctgaa ggttctaggg tggagctgcc ctgtcatttg     1200

cccccaggag tggggacccc ttctttgctc attgccaagt ggactcctcc tggaggaggt     1260

cctgagctcc ccgtggctgg aaagagtggc aattttaccc ttcaccttga ggctgtgggt     1320

ctggcacagg ctgggaccta cacctgtagc atccatctgc agggacagca gctcaatgcc     1380

actgtcacgt tggcggtcat cacagtgact cccaaatcct tcgggttacc tggctcccgg     1440

gggaagctgt tgtgtgaggt aaccccggca tctggaaagg aaagatttgt gtggcgtccc     1500

ctgaacaatc tgtccaggag ttgcccgggc cctgtgctgg agattcagga ggccaggctc     1560

cttgctgagc gatggcagtg tcagctgtac gagggccaga ggcttcttgg agcgacagtg     1620

tacgccgcag agtctagctc aggcgcccac agtgctagga gaatctcagg tgaccttaaa     1680

ggaggccatc tcgttctcgt tctcatcctt ggtgccctct ccctgttcct tttggtggcc     1740

ggggcctttg gctttcactg gtggagaaaa cagttgctac tgagaagatt ttctgcctta     1800

gaacatggga ttcagccatt tccggctcag aggaagatag aggagctgga gcgagaactg     1860

gagacggaga tgggacagga gccggagccc gagccggagc cacagctgga gccagagccc     1920

aggcagctct gacctggagc cgaggcagcc agcaggtctc agcagctccg cccgcccgcc     1980

cgcccgcccg aataaactcc ctgtcagcag catcaaaaaa aaaaaaaaaa aa             2032


<210>  31
<211>  525
<212>  PRT
<213>  Artificial Sequence

<400>  31

Met Arg Glu Asp Leu Leu Leu Gly Phe Leu Leu Leu Gly Leu Leu Trp 
1               5                   10                  15      


Glu Ala Pro Val Val Ser Ser Gly Pro Gly Ala Glu Val Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile 
        35                  40                  45              


Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu 
65                  70                  75                  80  


Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro 
                85                  90                  95      


Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly 
            100                 105                 110         


Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln 
        115                 120                 125             


Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala 
    130                 135                 140                 


Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys 
145                 150                 155                 160 


Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Ile Ala Ser Pro Ser 
                165                 170                 175     


Gly Val Leu Lys Leu Ser Asp Trp Val Leu Leu Asn Cys Ser Phe Ser 
            180                 185                 190         


Arg Pro Asp Arg Pro Val Ser Val His Trp Phe Gln Gly Gln Asn Arg 
        195                 200                 205             


Val Pro Val Tyr Asn Ser Pro Arg His Phe Leu Ala Glu Thr Phe Leu 
    210                 215                 220                 


Leu Leu Pro Gln Val Ser Pro Leu Asp Ser Gly Thr Trp Gly Cys Val 
225                 230                 235                 240 


Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Thr Tyr Asn Leu Lys 
                245                 250                 255     


Val Leu Gly Leu Glu Pro Val Ala Pro Leu Thr Val Tyr Ala Ala Glu 
            260                 265                 270         


Gly Ser Arg Val Glu Leu Pro Cys His Leu Pro Pro Gly Val Gly Thr 
        275                 280                 285             


Pro Ser Leu Leu Ile Ala Lys Trp Thr Pro Pro Gly Gly Gly Pro Glu 
    290                 295                 300                 


Leu Pro Val Ala Gly Lys Ser Gly Asn Phe Thr Leu His Leu Glu Ala 
305                 310                 315                 320 


Val Gly Leu Ala Gln Ala Gly Thr Tyr Thr Cys Ser Ile His Leu Gln 
                325                 330                 335     


Gly Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Val Ile Thr Val Thr 
            340                 345                 350         


Pro Lys Ser Phe Gly Leu Pro Gly Ser Arg Gly Lys Leu Leu Cys Glu 
        355                 360                 365             


Val Thr Pro Ala Ser Gly Lys Glu Arg Phe Val Trp Arg Pro Leu Asn 
    370                 375                 380                 


Asn Leu Ser Arg Ser Cys Pro Gly Pro Val Leu Glu Ile Gln Glu Ala 
385                 390                 395                 400 


Arg Leu Leu Ala Glu Arg Trp Gln Cys Gln Leu Tyr Glu Gly Gln Arg 
                405                 410                 415     


Leu Leu Gly Ala Thr Val Tyr Ala Ala Glu Ser Ser Ser Gly Ala His 
            420                 425                 430         


Ser Ala Arg Arg Ile Ser Gly Asp Leu Lys Gly Gly His Leu Val Leu 
        435                 440                 445             


Val Leu Ile Leu Gly Ala Leu Ser Leu Phe Leu Leu Val Ala Gly Ala 
    450                 455                 460                 


Phe Gly Phe His Trp Trp Arg Lys Gln Leu Leu Leu Arg Arg Phe Ser 
465                 470                 475                 480 


Ala Leu Glu His Gly Ile Gln Pro Phe Pro Ala Gln Arg Lys Ile Glu 
                485                 490                 495     


Glu Leu Glu Arg Glu Leu Glu Thr Glu Met Gly Gln Glu Pro Glu Pro 
            500                 505                 510         


Glu Pro Glu Pro Gln Leu Glu Pro Glu Pro Arg Gln Leu 
        515                 520                 525 


<210>  32
<211>  869
<212>  DNA
<213>  Artificial Sequence

<400>  32
gaatcagccc cctcacactt tccactgcga agcgaaaccc cgcgccttgg tctggggggg       60

cgggcagtgg ggaggagaag cagaaggact gggtctggag gagcagctca agttctagct      120

agctgcagtg ggtttgcctg cactctgctc tgggtcccag cccgggcctc tgatcattat      180

ccatcctgct gtctccagtc cccactcctg gggcgtcctc ttcaccctac attctttccc      240

tccgcctcac ctcctccttg tagaacttct ctctctctct ctctctctct ctctctctct      300

ctctctctct ctctgtgtgt gtgtgtgtgt ctgtctgtct gtctgtctct ctctcctccc      360

aggacctttt tctaacctcc cttggagggc tggggaggcc cgggccatag aggagatgag      420

ggaggacctg ctccttggct ttttgcttct gggactgctt tgggaagctc caggtaaggt      480

ggagagtcca gcagggacct ctatggctgt ctctttagct gtggtgatat tccaatgctt      540

ttgttgaggg gaggggtgtg tgtgtgtgtg tgtgtgtgtg ttttgagaca gggtttcttt      600

gtgttgccct ggctgtcctg ggactggctc tgatgaccag gctggccttg aatttatagt      660

gatccacttg cctctgcctc cccagtgctg ggattagagg cgtgcaccat cactttgtat      720

aagggcagat cccaaagctg cctcagcctc ccttcaacag ggaggcatga tgtttctttc      780

ttaggaaagc cagggcattt ctctattctc caatctcttg gctcaatgcc cttggcctct      840

cttttgttcc actagttgtg tcttcaggg                                        869


<210>  33
<211>  52
<212>  DNA
<213>  Artificial Sequence

<400>  33
tttaagaagg agatatacat ggaattcgaa tcagccccct cacactttcc ac               52


<210>  34
<211>  38
<212>  DNA
<213>  Artificial Sequence

<400>  34
cctcagcccc tggccctgaa gacacaacta gtggaaca                               38


<210>  35
<211>  783
<212>  DNA
<213>  human

<400>  35
ccaggggctg aggtcccggt ggtgtgggcc caggaggggg ctcctgccca gctcccctgc       60

agccccacaa tccccctcca ggatctcagc cttctgcgaa gagcaggggt cacttggcag      120

catcagccag acaggtatgc accccaaact tgggcaacag gacctccgaa tccagcactc      180

aaccccacac ccgtgccggt cctctgtccc ctgccctgag gtgtcactcc ctctgaagcc      240

agtgacccag tctccctgcc ctcgcttgca ccgttcctgc ccttgctctg caatcagcga      300

ccctcacgcc agcatccctt ctctccagaa gtggatgcgg ccagtccaac agaggggtcg      360

ggcgtgaggg gacggttggt ggtcaagaga actcttgggg cgggctttct catcctcaac      420

gggtggctgc ctgcatcctc ccgggcttcc tacccctgga gcttctcaac tccattctct      480

ttcccgccca gtggcccgcc cgctgccgcc cccggccatc ccctggcccc cggccctcac      540

ccggcggcgc cctcctcctg ggggcccagg ccccgccgct acacggtgct gagcgtgggt      600

cccggaggcc tgcgcagcgg gaggctgccc ctgcagcccc gcgtccagct ggatgagcgc      660

ggccggcagc gcggggactt ctcgctatgg ctgcgcccag cccggcgcgc ggacgccggc      720

gagtaccgcg ccgcggtgca cctcagggac cgcgccctct cctgccgcct ccgtctgcgc      780

ctg                                                                    783


<210>  36
<211>  36
<212>  DNA
<213>  Artificial Sequence

<400>  36
gtgtcttcag ggccaggggc tgaggtcccg gtggtg                                 36


<210>  37
<211>  35
<212>  DNA
<213>  Artificial Sequence

<400>  37
tcgaggcctg gcccaggcgc agacggaggc ggcag                                  35


<210>  38
<211>  1415
<212>  DNA
<213>  Artificial Sequence

<400>  38
ggccaggcct cgagtaggtg gggccggaca aagggagaga gagggcctgg gaagcagatc       60

cctgcttccc ccggggcagg gagagcaatg gctaggggtt gtgatttaga ccctgtctga      120

ggacctccag aagtgtagaa gaagggatgg ccccctgatg gcaggatgga aaggcaggtt      180

ggaaagtgcc ccctgaaacg ctcgccttta ggcggggatg agggggctat ggagaaattg      240

tatcacccca cccccttcca actccctttc ccccacctac tgcgggagtg ccatcccttg      300

tagaggtaga gatggggaag cacctcttct ttggggggct agagtgattc atctaagata      360

tctgtagctc gtccttaggc caggtctgcc caaagccaag taaagtagag gcaggaggcc      420

gtggaaaaga gtcccgggtc tcttggagat ccacccataa acatccccag gtttcaagaa      480

ctgacttgga atgagcgggt gtgtggagaa tctgaaagca atgccccatt tctatgagtt      540

tttcagcttg gtttggccgg ctgcgttgag aaagcatttc catctattgg actgattttt      600

tttttttttt ttttaacttt tgcacagtga ttgctagtcc ctcaggagtc ctcaagctgt      660

ctgattgggt ccttttgaac tgctccttca gccgtcctga ccgcccagtc tctgtgcact      720

ggttccaggg ccagaaccga gtgcctgtct acaactcacc gcgtcatttt ttagctgaaa      780

ctttcctgtt actgccccaa gtcagccccc tggactctgg gacctggggc tgtgtcctca      840

cctacagaga tggcttcaat gtctccatca cgtacaacct caaggttctg ggtaactctt      900

ctaagcagcc ttgaccacaa ccttcctgct caccacctct cctgactcat gcatggaccc      960

ccaaaacttt ctcagctgcg tgtggtctca ctccacatca ctttgtttca gtgtccaaac     1020

cattttctct ctgggcatct tttagctgct gtctctctta cttttattta tttatttgtg     1080

tgtttattta tttattttca ttttagcgtg cgttggtgtt ttgcctgcat agatgtctgt     1140

gtcagggtat tggattccct ggaacttgac ctacagacag tcatgagata ccatatgggt     1200

gctgggaatt gaacccagct cctctggaag gacagccagt gttctaatct gccatctctc     1260

actgtttatc ccttggctgt tcagcctcct gagcctttgg tctcttgctg cctcagtttc     1320

cctagtttct ctgctttgct ctgtttcttt ctgtgttaca gccaaatgcc tccttccccc     1380

ttctgcctta cttccttgat gtctccaccc tctgg                                1415


<210>  39
<211>  34
<212>  DNA
<213>  Artificial Sequence

<400>  39
cgtctgcgcc tgggccaggc ctcgagtagg tggg                                   34


<210>  40
<211>  52
<212>  DNA
<213>  Artificial Sequence

<400>  40
ttgttagcag ccggatctca gggatcccca gagggtggag acatcaagga ag               52


<210>  41
<211>  25
<212>  DNA
<213>  Artificial Sequence

<400>  41
agcattcaca cagggtgggg aattt                                             25


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<400>  42
ggcgtgaggg tcgctgattg                                                   20


<210>  43
<211>  24
<212>  DNA
<213>  Artificial Sequence

<400>  43
gacctccgaa tccagcactc aacc                                              24


<210>  44
<211>  25
<212>  DNA
<213>  Artificial Sequence

<400>  44
aggagtccac ttggcaatga gcaaa                                             25


<210>  45
<211>  22
<212>  DNA
<213>  Artificial Sequence

<400>  45
ggccacttat catcacttgc cc                                                22


<210>  46
<211>  21
<212>  DNA
<213>  Artificial Sequence

<400>  46
ggtggtaaag gggcctagga g                                                 21


<210>  47
<211>  21
<212>  DNA
<213>  Artificial Sequence

<400>  47
cagggagagc aatggctagg g                                                 21


<210>  48
<211>  25
<212>  DNA
<213>  Artificial Sequence

<400>  48
gctgaaaaac tcatagaaat ggggc                                             25


<210>  49
<211>  22
<212>  DNA
<213>  Artificial Sequence

<400>  49
gctttgggaa gctccaggta ag                                                22


<210>  50
<211>  24
<212>  DNA
<213>  Artificial Sequence

<400>  50
caagggatgg cactcccgca gtag                                              24


<210>  51
<211>  25
<212>  DNA
<213>  Artificial Sequence

<400>  51
gcttggacag ggttttatcc attag                                             25


<210>  52
<211>  25
<212>  DNA
<213>  Artificial Sequence

<400>  52
cttccacatg agcgtggtca gggcc                                             25


<210>  53
<211>  25
<212>  DNA
<213>  Artificial Sequence

<400>  53
ccaagggact attttagatg ggcag                                             25


<210>  54
<211>  26
<212>  DNA
<213>  Artificial Sequence

<400>  54
gaagctacaa gctcctaggt aggggg                                            26


<210>  55
<211>  23
<212>  DNA
<213>  Artificial Sequence

<400>  55
acgggttggc tcaaaccatt aca                                               23


<210>  56
<211>  25
<212>  DNA
<213>  Artificial Sequence

<400>  56
acagctgaaa gatgggaagt ggagt                                             25


<210>  57
<211>  28
<212>  DNA
<213>  Artificial Sequence

<400>  57
tcaactcatt ccccatcatg taggttgc                                          28


<210>  58
<211>  25
<212>  DNA
<213>  Artificial Sequence

<400>  58
ccatcacaca acactgatga ggtcc                                             25


<210>  59
<211>  25
<212>  DNA
<213>  Artificial Sequence

<400>  59
cacatcccca aatgcgtttc attgc                                             25


