                               SEQUENCE LISTING

<110> ENGENE, INC.
 
<120> INTESTINAL EXPRESSION OF PROGRAMMED DEATH LIGAND 1

<130> PAT 104260W-90

<140> PCT/CA2017/051340
<141> 2017-11-09

<150> US 62/419,899
<151> 2016-11-09

<160> 8     

<170> PatentIn version 3.5

<210> 1
<211> 290
<212> PRT
<213> Homo sapiens

<400> 1
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210> 2
<211> 873
<212> DNA
<213> Homo sapiens

<400> 2
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tggtcatccc agaactacct ctggcacatc ctccaaatga aaggactcac      720

ttggtaattc tgggagccat cttattatgc cttggtgtag cactgacatt catcttccgt      780

ttaagaaaag ggagaatgat ggatgtgaaa aaatgtggca tccaagatac aaactcaaag      840

aagcaaagtg atacacattt ggaggagacg taa                                   873


<210> 3
<211> 873
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
atgagaatct tcgcggtgtt catcttcatg acctactggc acctcctgaa cgctttcact       60

gtgaccgtgc ctaaggacct ctacgtcgtg gaatacggct ccaacatgac catcgagtgc      120

aaattcccag tggagaagca gctggacctg gctgccctga tcgtgtactg ggaaatggag      180

gacaagaaca tcatccaatt cgtgcatggg gaggaggacc tgaaggtcca gcattcgtca      240

tatcggcaaa gagccaggct gctgaaggat cagctgtccc tcggcaatgc ggcactgcag      300

attaccgatg tgaagctgca ggacgccgga gtctaccggt gcatgatttc ctacggcgga      360

gcagactaca agcgcattac cgtgaaggtc aacgctccct acaacaagat caaccagcgg      420

attctggtgg tcgaccctgt gacctccgag catgagctga cctgtcaagc cgaaggttac      480

ccgaaagcgg aagtgatctg gacgtcgagc gaccaccagg tcttgagcgg aaagacgacc      540

actactaaca gcaagcggga agagaaactg tttaacgtga ccagcactct tcggatcaac      600

accaccacta acgagatttt ctactgtacc tttcgccggc ttgacccgga agaaaatcac      660

accgccgagc tcgtgatccc cgagctgccc ctcgcccacc ctcctaacga aagaacccac      720

ctggtcatct tgggggccat cctgctgtgc ctgggagtgg ccctgacctt catttttagg      780

ctccgaaagg gccgcatgat ggacgtgaag aaatgcggaa tccaggacac taactccaag      840

aagcagtccg atactcacct ggaagaaacc tag                                   873


<210> 4
<211> 1410
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
atgagaatct tcgcggtgtt catcttcatg acctactggc acctcctgaa cgctttcact       60

gtgaccgtgc ctaaggacct ctacgtcgtg gaatacggct ccaacatgac catcgagtgc      120

aaattcccag tggagaagca gctggacctg gctgccctga tcgtgtactg ggaaatggag      180

gacaagaaca tcatccaatt cgtgcatggg gaggaggacc tgaaggtcca gcattcgtca      240

tatcggcaaa gagccaggct gctgaaggat cagctgtccc tcggcaatgc ggcactgcag      300

attaccgatg tgaagctgca ggacgccgga gtctaccggt gcatgatttc ctacggcgga      360

gcagactaca agcgcattac cgtgaaggtc aacgctccct acaacaagat caaccagcgg      420

attctggtgg tcgaccctgt gacctccgag catgagctga cctgtcaagc cgaaggttac      480

ccgaaagcgg aagtgatctg gacgtcgagc gaccaccagg tcttgagcgg aaagacgacc      540

actactaaca gcaagcggga agagaaactg tttaacgtga ccagcactct tcggatcaac      600

accaccacta acgagatttt ctactgtacc tttcgccggc ttgacccgga agaaaatcac      660

accgccgagc tcgtgatccc cgagctgccc ctcgcccacc ctcctaacga aagaactccc      720

aagtcttgcg ataagaccca cacatgcccg ccatgcccag ccccgcccgt ggcgggcccc      780

tccgtgtttc ttttcccgcc gaagcctaag gataccctga tgatctcccg cacccccgaa      840

gtcacttgtg tggtggtgga cgtcagccac gaagatccgg aagtcaagtt caattggtac      900

gtggacgggg tcgaagtgca caacgccaag accaagcccc gcgaggaaca gtacaactca      960

acgtaccggg tggtgtccgt gctgaccgtg ctgcatcagg actggctgaa cggaaaggag     1020

tacaagtgca aagtgtccaa caagggactg ccgagctcga tcgaaaagac catttcgaag     1080

gccaaggggc agcctaggga gccacaggtc tataccctcc cgccctcacg agatgaactg     1140

accaagaacc aagtgtcatt gacttgcctc gtgaagggct tctacccttc cgacatcgcc     1200

gtggaatggg aatccaacgg acagccggag aacaactaca agactactcc gcccgtgctt     1260

gactccgacg gttcgttctt cctgtactcc aagctgaccg tggataagtc ccgctggcaa     1320

cagggcaacg tgttctcctg ctccgtgatg cacgaagccc tgcacaacca ctacacccag     1380

aagtccctct cgttgagccc tggaaaatag                                      1410


<210> 5
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Gly Gly Gly Gly Ser 
1               5   


<210> 6
<211> 3832
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt       60

cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt      120

ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt      180

tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga      240

taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag      300

caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata      360

agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg      420

gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga      480

gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca      540

ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa      600

acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt      660

tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac      720

ggttcctggg cttttgctgg ccttttgctc acatgttctt gactcttcgc gatgtacggg      780

ccagatatac gcgttgacat tgattattga ctagttatta atagtaatca attacggggt      840

cattagttca tagcccatat atggagttcc gcgttacata acttacggta aatggcccgc      900

ctggctgacc gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag      960

taacgccaat agggactttc cattgacgtc aatgggtgga ctatttacgg taaactgccc     1020

acttggcagt acatcaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg     1080

gtaaatggcc cgcctggcat tatgcccagt acatgacctt atgggacttt cctacttggc     1140

agtacatcta cgtattagtc atcgctatta ccatggtgat gcggttttgg cagtacatca     1200

atgggcgtgg atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca     1260

atgggagttt gttttggcac caaaatcaac gggactttcc aaaatgtcgt aacaactccg     1320

ccccattgac gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctc     1380

tctggctaac tagagaaccc actgcttact ggcttatcga aattaatacg actcactata     1440

gggagaccca agctggctag cgtttaaact taagcttcca ccatgagaat cttcgcggtg     1500

ttcatcttca tgacctactg gcacctcctg aacgctttca ctgtgaccgt gcctaaggac     1560

ctctacgtcg tggaatacgg ctccaacatg accatcgagt gcaaattccc agtggagaag     1620

cagctggacc tggctgccct gatcgtgtac tgggaaatgg aggacaagaa catcatccaa     1680

ttcgtgcatg gggaggagga cctgaaggtc cagcattcgt catatcggca aagagccagg     1740

ctgctgaagg atcagctgtc cctcggcaat gcggcactgc agattaccga tgtgaagctg     1800

caggacgccg gagtctaccg gtgcatgatt tcctacggcg gagcagacta caagcgcatt     1860

accgtgaagg tcaacgctcc ctacaacaag atcaaccagc ggattctggt ggtcgaccct     1920

gtgacctccg agcatgagct gacctgtcaa gccgaaggtt acccgaaagc ggaagtgatc     1980

tggacgtcga gcgaccacca ggtcttgagc ggaaagacga ccactactaa cagcaagcgg     2040

gaagagaaac tgtttaacgt gaccagcact cttcggatca acaccaccac taacgagatt     2100

ttctactgta cctttcgccg gcttgacccg gaagaaaatc acaccgccga gctcgtgatc     2160

cccgagctgc ccctcgccca ccctcctaac gaaagaaccc acctggtcat cttgggggcc     2220

atcctgctgt gcctgggagt ggccctgacc ttcattttta ggctccgaaa gggccgcatg     2280

atggacgtga agaaatgcgg aatccaggac actaactcca agaagcagtc cgatactcac     2340

ctggaagaaa cctaggaatt ccagcacagt ggcggccgct cgagtctaga gggcccgttt     2400

aaacccgctg atcagcctcg actgtgcctt ctagttgcca gccatctgtt gtttgcccct     2460

cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc taataaaatg     2520

aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt ggggtggggc     2580

aggacagcaa gggggaggat tgggaagaca atagcaggca tgctggggat gcggtgggct     2640

ctatggcttc tactgggcgg ttttatggac agcaagcgaa ccggaattgc cagctggggc     2700

gccctctggt aaggttggga agccctgcaa agtaaactgg atggctttct cgccgccaag     2760

gatctgatgg cgcaggggat caagctctga tcaagagaca ggatgaggat cgtttcgcat     2820

gattgaacaa gatggattgc acgcaggttc tccggccgct tgggtggaga ggctattcgg     2880

ctatgactgg gcacaacaga caatcggctg ctctgatgcc gccgtgttcc ggctgtcagc     2940

gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc ggtgccctga atgaactgca     3000

agacgaggca gcgcggctat cgtggctggc cacgacgggc gttccttgcg cagctgtgct     3060

cgacgttgtc actgaagcgg gaagggactg gctgctattg ggcgaagtgc cggggcagga     3120

tctcctgtca tctcaccttg ctcctgccga gaaagtatcc atcatggctg atgcaatgcg     3180

gcggctgcat acgcttgatc cggctacctg cccattcgac caccaagcga aacatcgcat     3240

cgagcgagca cgtactcgga tggaagccgg tcttgtcgat caggatgatc tggacgaaga     3300

gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc aaggcgagca tgcccgacgg     3360

cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg aatatcatgg tggaaaatgg     3420

ccgcttttct ggattcatcg actgtggccg gctgggtgtg gcggaccgct atcaggacat     3480

agcgttggct acccgtgata ttgctgaaga gcttggcggc gaatgggctg accgcttcct     3540

cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc gccttctatc gccttcttga     3600

cgagttcttc tgaattatta acgcttacaa tttcctgatg cggtattttc tccttacgca     3660

tctgtgcggt atttcacacc gcatacaggt ggcacttttc ggggaaatgt gcgcggaacc     3720

cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc     3780

tgataaatgc ttcaataata gcacgtgcta aaacttcatt tttaatttaa aa             3832


<210> 7
<211> 4369
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt       60

cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt      120

ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt      180

tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga      240

taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag      300

caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata      360

agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg      420

gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga      480

gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca      540

ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa      600

acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt      660

tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac      720

ggttcctggg cttttgctgg ccttttgctc acatgttctt gactcttcgc gatgtacggg      780

ccagatatac gcgttgacat tgattattga ctagttatta atagtaatca attacggggt      840

cattagttca tagcccatat atggagttcc gcgttacata acttacggta aatggcccgc      900

ctggctgacc gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag      960

taacgccaat agggactttc cattgacgtc aatgggtgga ctatttacgg taaactgccc     1020

acttggcagt acatcaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg     1080

gtaaatggcc cgcctggcat tatgcccagt acatgacctt atgggacttt cctacttggc     1140

agtacatcta cgtattagtc atcgctatta ccatggtgat gcggttttgg cagtacatca     1200

atgggcgtgg atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca     1260

atgggagttt gttttggcac caaaatcaac gggactttcc aaaatgtcgt aacaactccg     1320

ccccattgac gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctc     1380

tctggctaac tagagaaccc actgcttact ggcttatcga aattaatacg actcactata     1440

gggagaccca agctggctag cgtttaaact taagcttcca ccatgagaat cttcgcggtg     1500

ttcatcttca tgacctactg gcacctcctg aacgctttca ctgtgaccgt gcctaaggac     1560

ctctacgtcg tggaatacgg ctccaacatg accatcgagt gcaaattccc agtggagaag     1620

cagctggacc tggctgccct gatcgtgtac tgggaaatgg aggacaagaa catcatccaa     1680

ttcgtgcatg gggaggagga cctgaaggtc cagcattcgt catatcggca aagagccagg     1740

ctgctgaagg atcagctgtc cctcggcaat gcggcactgc agattaccga tgtgaagctg     1800

caggacgccg gagtctaccg gtgcatgatt tcctacggcg gagcagacta caagcgcatt     1860

accgtgaagg tcaacgctcc ctacaacaag atcaaccagc ggattctggt ggtcgaccct     1920

gtgacctccg agcatgagct gacctgtcaa gccgaaggtt acccgaaagc ggaagtgatc     1980

tggacgtcga gcgaccacca ggtcttgagc ggaaagacga ccactactaa cagcaagcgg     2040

gaagagaaac tgtttaacgt gaccagcact cttcggatca acaccaccac taacgagatt     2100

ttctactgta cctttcgccg gcttgacccg gaagaaaatc acaccgccga gctcgtgatc     2160

cccgagctgc ccctcgccca ccctcctaac gaaagaactc ccaagtcttg cgataagacc     2220

cacacatgcc cgccatgccc agccccgccc gtggcgggcc cctccgtgtt tcttttcccg     2280

ccgaagccta aggataccct gatgatctcc cgcacccccg aagtcacttg tgtggtggtg     2340

gacgtcagcc acgaagatcc ggaagtcaag ttcaattggt acgtggacgg ggtcgaagtg     2400

cacaacgcca agaccaagcc ccgcgaggaa cagtacaact caacgtaccg ggtggtgtcc     2460

gtgctgaccg tgctgcatca ggactggctg aacggaaagg agtacaagtg caaagtgtcc     2520

aacaagggac tgccgagctc gatcgaaaag accatttcga aggccaaggg gcagcctagg     2580

gagccacagg tctataccct cccgccctca cgagatgaac tgaccaagaa ccaagtgtca     2640

ttgacttgcc tcgtgaaggg cttctaccct tccgacatcg ccgtggaatg ggaatccaac     2700

ggacagccgg agaacaacta caagactact ccgcccgtgc ttgactccga cggttcgttc     2760

ttcctgtact ccaagctgac cgtggataag tcccgctggc aacagggcaa cgtgttctcc     2820

tgctccgtga tgcacgaagc cctgcacaac cactacaccc agaagtccct ctcgttgagc     2880

cctggaaaat aggaattcca gcacagtggc ggccgctcga gtctagaggg cccgtttaaa     2940

cccgctgatc agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc     3000

ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg     3060

aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg     3120

acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta     3180

tggcttctac tgggcggttt tatggacagc aagcgaaccg gaattgccag ctggggcgcc     3240

ctctggtaag gttgggaagc cctgcaaagt aaactggatg gctttctcgc cgccaaggat     3300

ctgatggcgc aggggatcaa gctctgatca agagacagga tgaggatcgt ttcgcatgat     3360

tgaacaagat ggattgcacg caggttctcc ggccgcttgg gtggagaggc tattcggcta     3420

tgactgggca caacagacaa tcggctgctc tgatgccgcc gtgttccggc tgtcagcgca     3480

ggggcgcccg gttctttttg tcaagaccga cctgtccggt gccctgaatg aactgcaaga     3540

cgaggcagcg cggctatcgt ggctggccac gacgggcgtt ccttgcgcag ctgtgctcga     3600

cgttgtcact gaagcgggaa gggactggct gctattgggc gaagtgccgg ggcaggatct     3660

cctgtcatct caccttgctc ctgccgagaa agtatccatc atggctgatg caatgcggcg     3720

gctgcatacg cttgatccgg ctacctgccc attcgaccac caagcgaaac atcgcatcga     3780

gcgagcacgt actcggatgg aagccggtct tgtcgatcag gatgatctgg acgaagagca     3840

tcaggggctc gcgccagccg aactgttcgc caggctcaag gcgagcatgc ccgacggcga     3900

ggatctcgtc gtgacccatg gcgatgcctg cttgccgaat atcatggtgg aaaatggccg     3960

cttttctgga ttcatcgact gtggccggct gggtgtggcg gaccgctatc aggacatagc     4020

gttggctacc cgtgatattg ctgaagagct tggcggcgaa tgggctgacc gcttcctcgt     4080

gctttacggt atcgccgctc ccgattcgca gcgcatcgcc ttctatcgcc ttcttgacga     4140

gttcttctga attattaacg cttacaattt cctgatgcgg tattttctcc ttacgcatct     4200

gtgcggtatt tcacaccgca tacaggtggc acttttcggg gaaatgtgcg cggaacccct     4260

atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga     4320

taaatgcttc aataatagca cgtgctaaaa cttcattttt aatttaaaa                 4369


<210> 8
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


