                         SEQUENCE LISTING

<110>  Commonwealth Scientific and Industrial Research 
       Organisation
 
<120>  PROTEASE SENSOR MOLECULES

<130>  526697

<150>  2016904639
<151>  2016-11-14

<150>  2017900161
<151>  2017-01-19

<160>  123   

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease sensor molecule

<400>  1

Lys Gln Lys Gln 
1               


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  2

Lys Gln Ser Phe 
1               


<210>  3
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  3

Lys Gln Phe Met 
1               


<210>  4
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  4

Lys Gln Lys Lys 
1               


<210>  5
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  5

Lys Gln Lys Asn 
1               


<210>  6
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  6

Lys Gln Asn Gln 
1               


<210>  7
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  7

Lys Gln Asn Thr 
1               


<210>  8
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  8

Lys Gln Glu Ile 
1               


<210>  9
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  9

Ser Phe Ser Phe 
1               


<210>  10
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  10

Ser Phe Phe Met 
1               


<210>  11
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  11

Ser Phe Lys Lys 
1               


<210>  12
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  12

Ser Phe Lys Asn 
1               


<210>  13
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  13

Ser Phe Asn Gln 
1               


<210>  14
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  14

Ser Phe Asn Thr 
1               


<210>  15
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  15

Ser Phe Glu Ile 
1               


<210>  16
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  16

Phe Met Phe Met 
1               


<210>  17
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  17

Phe Met Lys Lys 
1               


<210>  18
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  18

Phe Met Lys Asn 
1               


<210>  19
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  19

Phe Met Asn Gln 
1               


<210>  20
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  20

Phe Met Asn Thr 
1               


<210>  21
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  21

Phe Met Glu Ile 
1               


<210>  22
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  22

Lys Lys Lys Lys 
1               


<210>  23
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  23

Lys Lys Lys Asn 
1               


<210>  24
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  24

Lys Lys Asn Gln 
1               


<210>  25
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  25

Lys Lys Asn Thr 
1               


<210>  26
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  26

Lys Lys Glu Ile 
1               


<210>  27
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  27

Lys Asn Lys Asn 
1               


<210>  28
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  28

Lys Asn Asn Gln 
1               


<210>  29
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  29

Lys Asn Asn Thr 
1               


<210>  30
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  30

Lys Asn Glu Ile 
1               


<210>  31
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  31

Lys Asn Phe Met 
1               


<210>  32
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  32

Lys Asn Lys Lys 
1               


<210>  33
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  33

Asn Gln Asn Gln 
1               


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  34

Asn Thr Asn Thr 
1               


<210>  35
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  35

Asn Thr Glu Ile 
1               


<210>  36
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  36

Glu Ile Glu Ile 
1               


<210>  37
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  37

Ser Phe Met 
1           


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  38

Ser Phe Met Lys Lys Asn Gln 
1               5           


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  39

Lys Lys Asn Gln Ser Phe Met 
1               5           


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule


<220>
<221>  X
<222>  (4)..(5)
<223>  X can be any amino acid

<400>  40

Ser Lys Met Xaa Xaa Pro Pro 
1               5           


<210>  41
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule


<220>
<221>  X
<222>  (3)..(5)
<223>  X can be any amino acid

<220>
<221>  X
<222>  (9)..(10)
<223>  X can be any amino acid

<400>  41

Pro Pro Xaa Xaa Xaa Ser Lys Met Xaa Xaa Pro Pro 
1               5                   10          


<210>  42
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule


<220>
<221>  X
<222>  (3)..(4)
<223>  X can be any amino acid

<220>
<221>  X
<222>  (8)..(9)
<223>  X can be any amino acid

<400>  42

Pro Pro Xaa Xaa Ser Lys Met Xaa Xaa Pro Pro 
1               5                   10      


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule


<220>
<221>  X
<222>  (3)..(3)
<223>  X can be any amino acid

<220>
<221>  X
<222>  (7)..(8)
<223>  X can be any amino acid

<400>  43

Pro Pro Xaa Ser Lys Met Xaa Xaa Pro Pro 
1               5                   10  


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  44

Pro Pro Val Lys Gln Pro Pro Pro 
1               5               


<210>  45
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  45

Ser Phe Met Lys Lys Asn Gln Asn Thr Glu Ile 
1               5                   10      


<210>  46
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  46

Ser Phe Met Asn Thr Lys Lys Asn Gln Glu Ile 
1               5                   10      


<210>  47
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  47

Ser Phe Met Gln Asn Thr Glu Ile Lys Lys Asn 
1               5                   10      


<210>  48
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  48

Ser Phe Met Asn Gln Lys Lys Asn Thr Glu Ile 
1               5                   10      


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  49

Ser Phe Met Asn Gln Asn Thr Lys Lys Glu Ile 
1               5                   10      


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  50

Ser Phe Met Asn Gln Asn Thr Glu Ile Lys Lys 
1               5                   10      


<210>  51
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  51

Lys Lys Asn Gln Ser Phe Met Asn Thr Glu Ile 
1               5                   10      


<210>  52
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  52

Lys Lys Asn Gln Asn Thr Ser Phe Met Glu Ile 
1               5                   10      


<210>  53
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  53

Lys Lys Asn Gln Asn Thr Glu Ile Ser Phe Met 
1               5                   10      


<210>  54
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  54

Lys Lys Ser Phe Met Asn Gln Asn Thr Glu Ile 
1               5                   10      


<210>  55
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  55

Lys Lys Asn Gln Ser Phe Met Glu Ile Asn Thr 
1               5                   10      


<210>  56
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  56

Lys Lys Asn Gln Glu Ile Ser Phe Met Asn Thr 
1               5                   10      


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  57

Ser Phe Met Asn Gln Asn Thr Glu Ile 
1               5                   


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  58

Asn Gln Ser Phe Met Asn Thr Glu Ile 
1               5                   


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  59

Asn Gln Asn Thr Ser Phe Met Glu Ile 
1               5                   


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  60

Asn Gln Asn Thr Glu Ile Ser Phe Met 
1               5                   


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  61

Ser Phe Met Asn Thr Asn Gln Glu Ile 
1               5                   


<210>  62
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  62

Ser Phe Met Asn Thr Glu Ile Asn Gln 
1               5                   


<210>  63
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  63

Ser Phe Met Asn Gln Glu Ile Asn Thr 
1               5                   


<210>  64
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  64

Asn Gln Ser Phe Met Glu Ile Asn Thr 
1               5                   


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  65

Asn Gln Glu Ile Ser Phe Met Asn Thr 
1               5                   


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  66

Ser Phe Met Glu Ile Asn Gln Asn Thr 
1               5                   


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  67

Glu Ile Ser Phe Met Asn Thr Asn Gln 
1               5                   


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  68

Glu Ile Asn Thr Ser Phe Met Asn Gln 
1               5                   


<210>  69
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  69

Glu Ile Asn Thr Asn Gln Ser Phe Met 
1               5                   


<210>  70
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  70

Leu Ser Phe Met Ala Ile Pro 
1               5           


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  71

Leu Phe Met Ser Phe Ala Ile Pro 
1               5               


<210>  72
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  72

Leu Gln Gly Ser Phe Met Lys Lys Asn Gln Asn Thr Glu Ile Gly Ser 
1               5                   10                  15      


Phe Glu 
        


<210>  73
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  73

Leu Gln Gly Ser Phe Met Asn Gln Asn Thr Glu Ile Gly Ser Phe Glu 
1               5                   10                  15      


<210>  74
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  74

Leu Gln Gly Ser Leu Ser Phe Met Ala Ile Pro Gly Ser Phe Glu 
1               5                   10                  15  


<210>  75
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  75

Lys Gln Gln Gln 
1               


<210>  76
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  76

Ser Phe Gln Gln 
1               


<210>  77
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  77

Phe Met Gln Gln 
1               


<210>  78
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  78

Lys Lys Gln Gln 
1               


<210>  79
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  79

Lys Asn Gln Gln 
1               


<210>  80
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  80

Asn Gln Gln Gln 
1               


<210>  81
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  81

Asn Thr Gln Gln 
1               


<210>  82
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  82

Glu Ile Gln Gln 
1               


<210>  83
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  83

Gln Gln Gln Gln 
1               


<210>  84
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  84

Gln Gln Lys Gln 
1               


<210>  85
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  85

Gln Gln Ser Phe 
1               


<210>  86
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  86

Gln Gln Phe Met 
1               


<210>  87
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  87

Gln Gln Lys Lys 
1               


<210>  88
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  88

Gln Gln Lys Asn 
1               


<210>  89
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  89

Gln Gln Asn Gln 
1               


<210>  90
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  90

Gln Gln Asn Thr 
1               


<210>  91
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  91

Gln Gln Glu Ile 
1               


<210>  92
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  92

Lys Gln Gln 
1           


<210>  93
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  93

Gly Ser Pro Pro Leu Gln Gln Pro Pro Pro Gly Ser 
1               5                   10          


<210>  94
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  94

Gly Gly Ser Gly Gly Ser Leu Lys Gln Gln Gly Gly Ser Gly Gly Ser 
1               5                   10                  15      


<210>  95
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  95

Leu Gln Gly 
1           


<210>  96
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  96

Gly Ser Phe Glu 
1               


<210>  97
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  97

Gly Ser Ser Gly Gly Ser 
1               5       


<210>  98
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  98

Gly Ser Pro Pro Leu 
1               5   


<210>  99
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  99

Pro Pro Pro Gly Ser 
1               5   


<210>  100
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease Sensor Molecule

<400>  100

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  101
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease Sensor Molecule

<400>  101

Gly Gly Ser Gly Gly Ser Leu 
1               5           


<210>  102
<211>  1713
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protease Sensor Molecule

<400>  102
gaattcatgg tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag       60

ctggacggcg acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc      120

acctacggca agctgaccct gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg      180

cccaccctcg tgaccaccct gagctacggc gtgcagtgct tcagccgcta ccccgaccac      240

atgaagcagc acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc      300

atcttcttca aggacgacgg caactacaag acccgcgccg aggtgaagtt cgagggcgac      360

accctggtga accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg      420

gggcacaagc tggagtacaa ctacaacagc cacaacgtct atatcatggc cgacaagcag      480

aagaacggca tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag      540

ctcgccgacc actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac      600

aaccactacc tgagcaccca gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac      660

atggtcctgc tggagttcgt gaccgccgcc gggatcactc tcggcatgga cgagctgtac      720

aagctgcagg gttcctttat gaaccagaac actgaaatcg gaagcttcga aatggcttcc      780

aaggtgtacg accccgagca acgcaaacgc atgatcactg ggcctcagtg gtgggctcgc      840

tgcaagcaaa tgaacgtgct ggactccttc atcaactact atgattccga gaagcacgcc      900

gagaacgccg tgatttttct gcatggtaac gctgcctcca gctacctgtg gaggcacgtc      960

gtgcctcaca tcgagcccgt ggctagatgc atcatccctg atctgatcgg aatgggtaag     1020

tccggcaaga gcgggaatgg ctcatatcgc ctcctggatc actacaagta cctcaccgct     1080

tggttcgagc tgctgaacct tccaaagaaa atcatctttg tgggccacga ctggggggct     1140

gctctggcct ttcactactc ctacgagcac caagacaaga tcaaggccat cgtccatgct     1200

gagagtgtcg tggacgtgat cgagtcctgg gacgagtggc ctgacatcga ggaggatatc     1260

gccctgatca agagcgaaga gggcgagaaa atggtgcttg agaataactt cttcgtcgag     1320

accgtgctcc caagcaagat catgcggaaa ctggagcctg aggagttcgc tgcctacctg     1380

gagccattca aggagaaggg cgaggttaga cggcctaccc tctcctggcc tcgcgagatc     1440

cctctcgtta agggaggcaa gcccgacgtc gtccagattg tccgcaacta caacgcctac     1500

cttcgggcca gcgacgatct gcctaagatg ttcatcgagt ccgaccctgg gttcttttcc     1560

aacgctattg tcgagggagc taagaagttc cctaacaccg agttcgtgaa ggtgaagggc     1620

ctccacttca gccaggagga cgctccagat gaaatgggta agtacatcaa gagcttcgtg     1680

gagcgcgtgc tgaagaacga gcagtaactc gag                                  1713


<210>  103
<211>  1713
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protease Sensor Molecule

<400>  103
gaattcatgg tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag       60

ctggacggcg acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc      120

acctacggca agctgaccct gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg      180

cccaccctcg tgaccaccct gagctacggc gtgcagtgct tcagccgcta ccccgaccac      240

atgaagcagc acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc      300

atcttcttca aggacgacgg caactacaag acccgcgccg aggtgaagtt cgagggcgac      360

accctggtga accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg      420

gggcacaagc tggagtacaa ctacaacagc cacaacgtct atatcatggc cgacaagcag      480

aagaacggca tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag      540

ctcgccgacc actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac      600

aaccactacc tgagcaccca gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac      660

atggtcctgc tggagttcgt gaccgccgcc gggatcactc tcggcatgga cgagctgtac      720

aagctgcagg gttcctttat gaaccagaac actgaaatcg gaagcttcga aatggcttcc      780

aaggtgtacg accccgagca acgcaaacgc atgatcactg ggcctcagtg gtgggctcgc      840

tgcaagcaaa tgaacgtgct ggactccttc atcaactact atgattccga gaagcacgcc      900

gagaacgccg tgatttttct gcatggtaac gctgcctcca gctacctgtg gaggcacgtc      960

gtgcctcaca tcgagcccgt ggctagatgc atcatccctg atctgatcgg aatgggtaag     1020

tccggcaaga gcgggaatgg ctcatatcgc ctcctggatc actacaagta cctcaccgct     1080

tggttcgagc tgctgaacct tccaaagaaa atcatctttg tgggccacga ctggggggct     1140

gctctggcct ttcactactc ctacgagcac caagacaaga tcaaggccat cgtccatgct     1200

gagagtgtcg tggacgtgat cgagtcctgg gacgagtggc ctgacatcga ggaggatatc     1260

gccctgatca agagcgaaga gggcgagaaa atggtgcttg agaataactt cttcgtcgag     1320

accgtgctcc caagcaagat catgcggaaa ctggagcctg aggagttcgc tgcctacctg     1380

gagccattca aggagaaggg cgaggttaga cggcctaccc tctcctggcc tcgcgagatc     1440

cctctcgtta agggaggcaa gcccgacgtc gtccagattg tccgcaacta caacgcctac     1500

cttcgggcca gcgacgatct gcctaagatg ttcatcgagt ccgaccctgg gttcttttcc     1560

aacgctattg tcgagggagc taagaagttc cctaacaccg agttcgtgaa ggtgaagggc     1620

ctccacttca gccaggagga cgctccagat gaaatgggta agtacatcaa gagcttcgtg     1680

gagcgcgtgc tgaagaacga gcagtaactc gag                                  1713


<210>  104
<211>  1710
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protease Sensor Molecule

<400>  104
gaattcatgg tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag       60

ctggacggcg acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc      120

acctacggca agctgaccct gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg      180

cccaccctcg tgaccaccct gagctacggc gtgcagtgct tcagccgcta ccccgaccac      240

atgaagcagc acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc      300

atcttcttca aggacgacgg caactacaag acccgcgccg aggtgaagtt cgagggcgac      360

accctggtga accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg      420

gggcacaagc tggagtacaa ctacaacagc cacaacgtct atatcatggc cgacaagcag      480

aagaacggca tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag      540

ctcgccgacc actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac      600

aaccactacc tgagcaccca gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac      660

atggtcctgc tggagttcgt gaccgccgcc gggatcactc tcggcatgga cgagctgtac      720

aagctgcagg gctctttaag ctttatggcc atccctggtt ccttcgaaat ggcttccaag      780

gtgtacgacc ccgagcaacg caaacgcatg atcactgggc ctcagtggtg ggctcgctgc      840

aagcaaatga acgtgctgga ctccttcatc aactactatg attccgagaa gcacgccgag      900

aacgccgtga tttttctgca tggtaacgct gcctccagct acctgtggag gcacgtcgtg      960

cctcacatcg agcccgtggc tagatgcatc atccctgatc tgatcggaat gggtaagtcc     1020

ggcaagagcg ggaatggctc atatcgcctc ctggatcact acaagtacct caccgcttgg     1080

ttcgagctgc tgaaccttcc aaagaaaatc atctttgtgg gccacgactg gggggctgct     1140

ctggcctttc actactccta cgagcaccaa gacaagatca aggccatcgt ccatgctgag     1200

agtgtcgtgg acgtgatcga gtcctgggac gagtggcctg acatcgagga ggatatcgcc     1260

ctgatcaaga gcgaagaggg cgagaaaatg gtgcttgaga ataacttctt cgtcgagacc     1320

gtgctcccaa gcaagatcat gcggaaactg gagcctgagg agttcgctgc ctacctggag     1380

ccattcaagg agaagggcga ggttagacgg cctaccctct cctggcctcg cgagatccct     1440

ctcgttaagg gaggcaagcc cgacgtcgtc cagattgtcc gcaactacaa cgcctacctt     1500

cgggccagcg acgatctgcc taagatgttc atcgagtccg accctgggtt cttttccaac     1560

gctattgtcg agggagctaa gaagttccct aacaccgagt tcgtgaaggt gaagggcctc     1620

cacttcagcc aggaggacgc tccagatgaa atgggtaagt acatcaagag cttcgtggag     1680

cgcgtgctga agaacgagca gtaactcgag                                      1710


<210>  105
<211>  568
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease Sensor Molecule

<400>  105

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Leu 
225                 230                 235                 240 


Gln Gly Ser Phe Met Lys Lys Asn Gln Asn Thr Glu Ile Gly Ser Phe 
                245                 250                 255     


Glu Met Ala Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile 
            260                 265                 270         


Thr Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp 
        275                 280                 285             


Ser Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val 
    290                 295                 300                 


Ile Phe Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg His Val 
305                 310                 315                 320 


Val Pro His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile 
                325                 330                 335     


Gly Met Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu 
            340                 345                 350         


Asp His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro 
        355                 360                 365             


Lys Lys Ile Ile Phe Val Gly His Asp Trp Gly Ala Ala Leu Ala Phe 
    370                 375                 380                 


His Tyr Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val His Ala 
385                 390                 395                 400 


Glu Ser Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile 
                405                 410                 415     


Glu Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val 
            420                 425                 430         


Leu Glu Asn Asn Phe Phe Val Glu Thr Val Leu Pro Ser Lys Ile Met 
        435                 440                 445             


Arg Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys 
    450                 455                 460                 


Glu Lys Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile 
465                 470                 475                 480 


Pro Leu Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn 
                485                 490                 495     


Tyr Asn Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met Phe Ile 
            500                 505                 510         


Glu Ser Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys 
        515                 520                 525             


Lys Phe Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Ser 
    530                 535                 540                 


Gln Glu Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val 
545                 550                 555                 560 


Glu Arg Val Leu Lys Asn Glu Gln 
                565             


<210>  106
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease Sensor Molecule

<400>  106

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Leu 
225                 230                 235                 240 


Gln Gly Ser Phe Met Asn Gln Asn Thr Glu Ile Gly Ser Phe Glu Met 
                245                 250                 255     


Ala Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr Gly 
            260                 265                 270         


Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser Phe 
        275                 280                 285             


Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile Phe 
    290                 295                 300                 


Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg His Val Val Pro 
305                 310                 315                 320 


His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly Met 
                325                 330                 335     


Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp His 
            340                 345                 350         


Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys Lys 
        355                 360                 365             


Ile Ile Phe Val Gly His Asp Trp Gly Ala Ala Leu Ala Phe His Tyr 
    370                 375                 380                 


Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val His Ala Glu Ser 
385                 390                 395                 400 


Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu Glu 
                405                 410                 415     


Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu Glu 
            420                 425                 430         


Asn Asn Phe Phe Val Glu Thr Val Leu Pro Ser Lys Ile Met Arg Lys 
        435                 440                 445             


Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu Lys 
    450                 455                 460                 


Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro Leu 
465                 470                 475                 480 


Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr Asn 
                485                 490                 495     


Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met Phe Ile Glu Ser 
            500                 505                 510         


Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys Phe 
        515                 520                 525             


Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Ser Gln Glu 
    530                 535                 540                 


Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu Arg 
545                 550                 555                 560 


Val Leu Lys Asn Glu Gln 
                565     


<210>  107
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease Sensor Molecule

<400>  107

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Leu 
225                 230                 235                 240 


Gln Gly Ser Leu Ser Phe Met Ala Ile Pro Gly Ser Phe Glu Met Ala 
                245                 250                 255     


Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr Gly Pro 
            260                 265                 270         


Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser Phe Ile 
        275                 280                 285             


Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile Phe Leu 
    290                 295                 300                 


His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg His Val Val Pro His 
305                 310                 315                 320 


Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly Met Gly 
                325                 330                 335     


Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp His Tyr 
            340                 345                 350         


Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys Lys Ile 
        355                 360                 365             


Ile Phe Val Gly His Asp Trp Gly Ala Ala Leu Ala Phe His Tyr Ser 
    370                 375                 380                 


Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val His Ala Glu Ser Val 
385                 390                 395                 400 


Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu Glu Asp 
                405                 410                 415     


Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu Glu Asn 
            420                 425                 430         


Asn Phe Phe Val Glu Thr Val Leu Pro Ser Lys Ile Met Arg Lys Leu 
        435                 440                 445             


Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu Lys Gly 
    450                 455                 460                 


Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro Leu Val 
465                 470                 475                 480 


Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr Asn Ala 
                485                 490                 495     


Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met Phe Ile Glu Ser Asp 
            500                 505                 510         


Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys Phe Pro 
        515                 520                 525             


Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Ser Gln Glu Asp 
    530                 535                 540                 


Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu Arg Val 
545                 550                 555                 560 


Leu Lys Asn Glu Gln 
                565 


<210>  108
<211>  1710
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protease Sensor Molecule

<400>  108
gaattcatgg tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag       60

ctggacggcg acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc      120

acctacggca agctgaccct gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg      180

cccaccctcg tgaccaccct gagctacggc gtgcagtgct tcagccgcta ccccgaccac      240

atgaagcagc acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc      300

atcttcttca aggacgacgg caactacaag acccgcgccg aggtgaagtt cgagggcgac      360

accctggtga accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg      420

gggcacaagc tggagtacaa ctacaacagc cacaacgtct atatcatggc cgacaagcag      480

aagaacggca tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag      540

ctcgccgacc actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac      600

aaccactacc tgagcaccca gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac      660

atggtcctgc tggagttcgt gaccgccgcc gggatcactc tcggcatgga cgagctgtac      720

aagctgcagg gttccaaaaa gtataaagtt aaggaaggat cacttcagat ggcttccaag      780

gtgtacgacc ccgagcaacg caaacgcatg atcactgggc ctcagtggtg ggctcgctgc      840

aagcaaatga acgtgctgga ctccttcatc aactactatg attccgagaa gcacgccgag      900

aacgccgtga tttttctgca tggtaacgct gcctccagct acctgtggag gcacgtcgtg      960

cctcacatcg agcccgtggc tagatgcatc atccctgatc tgatcggaat gggtaagtcc     1020

ggcaagagcg ggaatggctc atatcgcctc ctggatcact acaagtacct caccgcttgg     1080

ttcgagctgc tgaaccttcc aaagaaaatc atctttgtgg gccacgactg gggggctgct     1140

ctggcctttc actactccta cgagcaccaa gacaagatca aggccatcgt ccatgctgag     1200

agtgtcgtgg acgtgatcga gtcctgggac gagtggcctg acatcgagga ggatatcgcc     1260

ctgatcaaga gcgaagaggg cgagaaaatg gtgcttgaga ataacttctt cgtcgagacc     1320

gtgctcccaa gcaagatcat gcggaaactg gagcctgagg agttcgctgc ctacctggag     1380

ccattcaagg agaagggcga ggttagacgg cctaccctct cctggcctcg cgagatccct     1440

ctcgttaagg gaggcaagcc cgacgtcgtc cagattgtcc gcaactacaa cgcctacctt     1500

cgggccagcg acgatctgcc taagatgttc atcgagtccg accctgggtt cttttccaac     1560

gctattgtcg agggagctaa gaagttccct aacaccgagt tcgtgaaggt gaagggcctc     1620

cacttcagcc aggaggacgc tccagatgaa atgggtaagt acatcaagag cttcgtggag     1680

cgcgtgctga agaacgagca gtaactcgag                                      1710


<210>  109
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease Sensor Molecule

<400>  109

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Leu 
225                 230                 235                 240 


Gln Gly Ser Lys Lys Tyr Lys Val Lys Glu Gly Ser Leu Gln Met Ala 
                245                 250                 255     


Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr Gly Pro 
            260                 265                 270         


Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser Phe Ile 
        275                 280                 285             


Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile Phe Leu 
    290                 295                 300                 


His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg His Val Val Pro His 
305                 310                 315                 320 


Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly Met Gly 
                325                 330                 335     


Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp His Tyr 
            340                 345                 350         


Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys Lys Ile 
        355                 360                 365             


Ile Phe Val Gly His Asp Trp Gly Ala Ala Leu Ala Phe His Tyr Ser 
    370                 375                 380                 


Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val His Ala Glu Ser Val 
385                 390                 395                 400 


Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu Glu Asp 
                405                 410                 415     


Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu Glu Asn 
            420                 425                 430         


Asn Phe Phe Val Glu Thr Val Leu Pro Ser Lys Ile Met Arg Lys Leu 
        435                 440                 445             


Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu Lys Gly 
    450                 455                 460                 


Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro Leu Val 
465                 470                 475                 480 


Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr Asn Ala 
                485                 490                 495     


Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met Phe Ile Glu Ser Asp 
            500                 505                 510         


Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys Phe Pro 
        515                 520                 525             


Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Ser Gln Glu Asp 
    530                 535                 540                 


Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu Arg Val 
545                 550                 555                 560 


Leu Lys Asn Glu Gln 
                565 


<210>  110
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule


<220>
<221>  X
<222>  (3)..(6)
<223>  X can be any amino acid

<220>
<221>  Z
<222>  (8)..(8)
<223>  Z is is lysine, tyrosine, valine or glutamic acid

<400>  110

Leu Gln Xaa Xaa Xaa Xaa Lys Glx Lys Leu Gln 
1               5                   10      


<210>  111
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  111

Leu Gln Gly Ser Lys Lys Tyr Lys Val Lys Glu Gly Ser Leu Gln 
1               5                   10                  15  


<210>  112
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  112

Leu Gln Gly Ser Lys Gln Lys Gln Lys Gln Lys Gln Gly Ser Phe Glu 
1               5                   10                  15      


<210>  113
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  113

Leu Gln Gly Ser Pro Pro Leu Lys Gln Pro Pro Pro Gly Ser Phe Glu 
1               5                   10                  15      


<210>  114
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  114

Leu Gln Gly Ser Pro Pro Leu Gln Gln Pro Gln Pro Gly Ser Phe Glu 
1               5                   10                  15      


<210>  115
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease sensor molecule

<400>  115

Leu Gln Gly Gly Ser Gly Gly Ser Leu Lys Gln Gln Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Phe Glu 
            20  


<210>  116
<211>  1701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding GFP2-Pflu-H1-RLuc2

<400>  116
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgagcta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagctg      720

cagggaagtc caccgttgaa acaaccccct cctggctcct tcgaaatggc ttccaaggtg      780

tacgaccccg agcaacgcaa acgcatgatc actgggcctc agtggtgggc tcgctgcaag      840

caaatgaacg tgctggactc cttcatcaac tactatgatt ccgagaagca cgccgagaac      900

gccgtgattt ttctgcatgg taacgctgcc tccagctacc tgtggaggca cgtcgtgcct      960

cacatcgagc ccgtggctag atgcatcatc cctgatctga tcggaatggg taagtccggc     1020

aagagcggga atggctcata tcgcctcctg gatcactaca agtacctcac cgcttggttc     1080

gagctgctga accttccaaa gaaaatcatc tttgtgggcc acgactgggg ggctgctctg     1140

gcctttcact actcctacga gcaccaagac aagatcaagg ccatcgtcca tgctgagagt     1200

gtcgtggacg tgatcgagtc ctgggacgag tggcctgaca tcgaggagga tatcgccctg     1260

atcaagagcg aagagggcga gaaaatggtg cttgagaata acttcttcgt cgagaccgtg     1320

ctcccaagca agatcatgcg gaaactggag cctgaggagt tcgctgccta cctggagcca     1380

ttcaaggaga agggcgaggt tagacggcct accctctcct ggcctcgcga gatccctctc     1440

gttaagggag gcaagcccga cgtcgtccag attgtccgca actacaacgc ctaccttcgg     1500

gccagcgacg atctgcctaa gatgttcatc gagtccgacc ctgggttctt ttccaacgct     1560

attgtcgagg gagctaagaa gttccctaac accgagttcg tgaaggtgaa gggcctccac     1620

ttcagccagg aggacgctcc agatgaaatg ggtaagtaca tcaagagctt cgtggagcgc     1680

gtgctgaaga acgagcagta a                                               1701


<210>  117
<211>  1707
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding GFP2-Pflu-H2-RLuc2

<400>  117
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgagcta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagctg      720

cagggatctc cacccttaca acaaccgcaa ccgggtagct tcgaaatggc ttccaaggtg      780

tacgaccccg agcaacgcaa acgcatgatc actgggcctc agtggtgggc tcgctgcaag      840

caaatgaacg tgctggactc cttcatcaac tactatgatt ccgagaagca cgccgagaac      900

gccgtgattt ttctgcatgg taacgctgcc tccagctacc tgtggaggca cgtcgtgcct      960

cacatcgagc ccgtggctag atgcatcatc cctgatctga tcggaatggg taagtccggc     1020

aagagcggga atggctcata tcgcctcctg gatcactaca agtacctcac cgcttggttc     1080

gagctgctga accttccaaa gaaaatcatc tttgtgggcc acgactgggg ggctgctctg     1140

gcctttcact actcctacga gcaccaagac aagatcaagg ccatcgtcca tgctgagagt     1200

gtcgtggacg tgatcgagtc ctgggacgag tggcctgaca tcgaggagga tatcgccctg     1260

atcaagagcg aagagggcga gaaaatggtg cttgagaata acttcttcgt cgagaccgtg     1320

ctcccaagca agatcatgcg gaaactggag cctgaggagt tcgctgccta cctggagcca     1380

ttcaaggaga agggcgaggt tagacggcct accctctcct ggcctcgcga gatccctctc     1440

gttaagggag gcaagcccga cgtcgtccag attgtccgca actacaacgc ctaccttcgg     1500

gccagcgacg atctgcctaa gatgttcatc gagtccgacc ctgggttctt ttccaacgct     1560

attgtcgagg gagctaagaa gttccctaac accgagttcg tgaaggtgaa gggcctccac     1620

ttcagccagg aggacgctcc agatgaaatg ggtaagtaca tcaagagctt cgtggagcgc     1680

gtgctgaaga acgagcagta actcgag                                         1707


<210>  118
<211>  1707
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding GFP2-Pflu-H3-RLuc2

<400>  118
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgagcta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagctg      720

caggggtcta aacaaaaaca gaagcaaaag caaggatcat tcgaaatggc ttccaaggtg      780

tacgaccccg agcaacgcaa acgcatgatc actgggcctc agtggtgggc tcgctgcaag      840

caaatgaacg tgctggactc cttcatcaac tactatgatt ccgagaagca cgccgagaac      900

gccgtgattt ttctgcatgg taacgctgcc tccagctacc tgtggaggca cgtcgtgcct      960

cacatcgagc ccgtggctag atgcatcatc cctgatctga tcggaatggg taagtccggc     1020

aagagcggga atggctcata tcgcctcctg gatcactaca agtacctcac cgcttggttc     1080

gagctgctga accttccaaa gaaaatcatc tttgtgggcc acgactgggg ggctgctctg     1140

gcctttcact actcctacga gcaccaagac aagatcaagg ccatcgtcca tgctgagagt     1200

gtcgtggacg tgatcgagtc ctgggacgag tggcctgaca tcgaggagga tatcgccctg     1260

atcaagagcg aagagggcga gaaaatggtg cttgagaata acttcttcgt cgagaccgtg     1320

ctcccaagca agatcatgcg gaaactggag cctgaggagt tcgctgccta cctggagcca     1380

ttcaaggaga agggcgaggt tagacggcct accctctcct ggcctcgcga gatccctctc     1440

gttaagggag gcaagcccga cgtcgtccag attgtccgca actacaacgc ctaccttcgg     1500

gccagcgacg atctgcctaa gatgttcatc gagtccgacc ctgggttctt ttccaacgct     1560

attgtcgagg gagctaagaa gttccctaac accgagttcg tgaaggtgaa gggcctccac     1620

ttcagccagg aggacgctcc agatgaaatg ggtaagtaca tcaagagctt cgtggagcgc     1680

gtgctgaaga acgagcagta actcgag                                         1707


<210>  119
<211>  1713
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding GFP2-Pflu-H4-RLuc2

<400>  119
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgagcta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaagctg      720

caggggggaa gcggtggtag tttgaaacag cagggcggat caggagggtc tttcgaaatg      780

gcttccaagg tgtacgaccc cgagcaacgc aaacgcatga tcactgggcc tcagtggtgg      840

gctcgctgca agcaaatgaa cgtgctggac tccttcatca actactatga ttccgagaag      900

cacgccgaga acgccgtgat ttttctgcat ggtaacgctg cctccagcta cctgtggagg      960

cacgtcgtgc ctcacatcga gcccgtggct agatgcatca tccctgatct gatcggaatg     1020

ggtaagtccg gcaagagcgg gaatggctca tatcgcctcc tggatcacta caagtacctc     1080

accgcttggt tcgagctgct gaaccttcca aagaaaatca tctttgtggg ccacgactgg     1140

ggggctgctc tggcctttca ctactcctac gagcaccaag acaagatcaa ggccatcgtc     1200

catgctgaga gtgtcgtgga cgtgatcgag tcctgggacg agtggcctga catcgaggag     1260

gatatcgccc tgatcaagag cgaagagggc gagaaaatgg tgcttgagaa taacttcttc     1320

gtcgagaccg tgctcccaag caagatcatg cggaaactgg agcctgagga gttcgctgcc     1380

tacctggagc cattcaagga gaagggcgag gttagacggc ctaccctctc ctggcctcgc     1440

gagatccctc tcgttaaggg aggcaagccc gacgtcgtcc agattgtccg caactacaac     1500

gcctaccttc gggccagcga cgatctgcct aagatgttca tcgagtccga ccctgggttc     1560

ttttccaacg ctattgtcga gggagctaag aagttcccta acaccgagtt cgtgaaggtg     1620

aagggcctcc acttcagcca ggaggacgct ccagatgaaa tgggtaagta catcaagagc     1680

ttcgtggagc gcgtgctgaa gaacgagcag taa                                  1713


<210>  120
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP2-Pflu-H1-RLuc2 fusion protein

<400>  120

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Leu 
225                 230                 235                 240 


Gln Gly Ser Pro Pro Leu Lys Gln Pro Pro Pro Gly Ser Phe Glu Met 
                245                 250                 255     


Ala Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr Gly 
            260                 265                 270         


Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser Phe 
        275                 280                 285             


Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile Phe 
    290                 295                 300                 


Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg His Val Val Pro 
305                 310                 315                 320 


His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly Met 
                325                 330                 335     


Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp His 
            340                 345                 350         


Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys Lys 
        355                 360                 365             


Ile Ile Phe Val Gly His Asp Trp Gly Ala Ala Leu Ala Phe His Tyr 
    370                 375                 380                 


Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val His Ala Glu Ser 
385                 390                 395                 400 


Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu Glu 
                405                 410                 415     


Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu Glu 
            420                 425                 430         


Asn Asn Phe Phe Val Glu Thr Val Leu Pro Ser Lys Ile Met Arg Lys 
        435                 440                 445             


Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu Lys 
    450                 455                 460                 


Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro Leu 
465                 470                 475                 480 


Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr Asn 
                485                 490                 495     


Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met Phe Ile Glu Ser 
            500                 505                 510         


Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys Phe 
        515                 520                 525             


Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Ser Gln Glu 
    530                 535                 540                 


Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu Arg 
545                 550                 555                 560 


Val Leu Lys Asn Glu Gln 
                565     


<210>  121
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP2-Pflu-H2-RLuc2 fusion protein

<400>  121

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Leu 
225                 230                 235                 240 


Gln Gly Ser Pro Pro Leu Gln Gln Pro Gln Pro Gly Ser Phe Glu Met 
                245                 250                 255     


Ala Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr Gly 
            260                 265                 270         


Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser Phe 
        275                 280                 285             


Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile Phe 
    290                 295                 300                 


Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg His Val Val Pro 
305                 310                 315                 320 


His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly Met 
                325                 330                 335     


Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp His 
            340                 345                 350         


Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys Lys 
        355                 360                 365             


Ile Ile Phe Val Gly His Asp Trp Gly Ala Ala Leu Ala Phe His Tyr 
    370                 375                 380                 


Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val His Ala Glu Ser 
385                 390                 395                 400 


Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu Glu 
                405                 410                 415     


Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu Glu 
            420                 425                 430         


Asn Asn Phe Phe Val Glu Thr Val Leu Pro Ser Lys Ile Met Arg Lys 
        435                 440                 445             


Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu Lys 
    450                 455                 460                 


Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro Leu 
465                 470                 475                 480 


Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr Asn 
                485                 490                 495     


Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met Phe Ile Glu Ser 
            500                 505                 510         


Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys Phe 
        515                 520                 525             


Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Ser Gln Glu 
    530                 535                 540                 


Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu Arg 
545                 550                 555                 560 


Val Leu Lys Asn Glu Gln Glu 
                565         


<210>  122
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP2-Pflu-H3-RLuc2 fusion protein

<400>  122

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Leu 
225                 230                 235                 240 


Gln Gly Ser Lys Gln Lys Gln Lys Gln Lys Gln Gly Ser Phe Glu Met 
                245                 250                 255     


Ala Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr Gly 
            260                 265                 270         


Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser Phe 
        275                 280                 285             


Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile Phe 
    290                 295                 300                 


Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg His Val Val Pro 
305                 310                 315                 320 


His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly Met 
                325                 330                 335     


Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp His 
            340                 345                 350         


Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys Lys 
        355                 360                 365             


Ile Ile Phe Val Gly His Asp Trp Gly Ala Ala Leu Ala Phe His Tyr 
    370                 375                 380                 


Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val His Ala Glu Ser 
385                 390                 395                 400 


Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu Glu 
                405                 410                 415     


Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu Glu 
            420                 425                 430         


Asn Asn Phe Phe Val Glu Thr Val Leu Pro Ser Lys Ile Met Arg Lys 
        435                 440                 445             


Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu Lys 
    450                 455                 460                 


Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro Leu 
465                 470                 475                 480 


Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr Asn 
                485                 490                 495     


Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met Phe Ile Glu Ser 
            500                 505                 510         


Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys Phe 
        515                 520                 525             


Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Ser Gln Glu 
    530                 535                 540                 


Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu Arg 
545                 550                 555                 560 


Val Leu Lys Asn Glu Gln 
                565     


<210>  123
<211>  570
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GFP2-Pflu-H4-RLuc2 fusion protein

<400>  123

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Leu 
225                 230                 235                 240 


Gln Gly Gly Ser Gly Gly Ser Leu Lys Gln Gln Gly Gly Ser Gly Gly 
                245                 250                 255     


Ser Phe Glu Met Ala Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg 
            260                 265                 270         


Met Ile Thr Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val 
        275                 280                 285             


Leu Asp Ser Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn 
    290                 295                 300                 


Ala Val Ile Phe Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg 
305                 310                 315                 320 


His Val Val Pro His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp 
                325                 330                 335     


Leu Ile Gly Met Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg 
            340                 345                 350         


Leu Leu Asp His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn 
        355                 360                 365             


Leu Pro Lys Lys Ile Ile Phe Val Gly His Asp Trp Gly Ala Ala Leu 
    370                 375                 380                 


Ala Phe His Tyr Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val 
385                 390                 395                 400 


His Ala Glu Ser Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro 
                405                 410                 415     


Asp Ile Glu Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys 
            420                 425                 430         


Met Val Leu Glu Asn Asn Phe Phe Val Glu Thr Val Leu Pro Ser Lys 
        435                 440                 445             


Ile Met Arg Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro 
    450                 455                 460                 


Phe Lys Glu Lys Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg 
465                 470                 475                 480 


Glu Ile Pro Leu Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val 
                485                 490                 495     


Arg Asn Tyr Asn Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met 
            500                 505                 510         


Phe Ile Glu Ser Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly 
        515                 520                 525             


Ala Lys Lys Phe Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His 
    530                 535                 540                 


Phe Ser Gln Glu Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser 
545                 550                 555                 560 


Phe Val Glu Arg Val Leu Lys Asn Glu Gln 
                565                 570 


