                         SEQUENCE LISTING

<110>  Advaxis, Inc.
       Hayes, Sandra M
       Kosoff, Rachelle
       Zou, June
 
<120>  Combination Of Listeria-Based Vaccine With Anti-CTLA-4 Or 
       Anti-CD137 Antibodies

<130>  062384/505725

<150>  62/418,690
<151>  2016-11-07

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  32
<212>  PRT
<213>  Listeria monocytogenes

<400>  1

Lys Glu Asn Ser Ile Ser Ser Met Ala Pro Pro Ala Ser Pro Pro Ala 
1               5                   10                  15      


Ser Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys 
            20                  25                  30          


<210>  2
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal fragment of an LLO protein

<400>  2

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Val Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Ser Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn 
            420                 425                 430         


Ile Ser Trp Asp Glu Val Asn Tyr Asp 
        435                 440     


<210>  3
<211>  529
<212>  PRT
<213>  Listeria monocytogenes

<400>  3

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Met Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Pro Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn 
            420                 425                 430         


Ile Ser Trp Asp Glu Val Asn Tyr Asp Pro Glu Gly Asn Glu Ile Val 
        435                 440                 445             


Gln His Lys Asn Trp Ser Glu Asn Asn Lys Ser Lys Leu Ala His Phe 
    450                 455                 460                 


Thr Ser Ser Ile Tyr Leu Pro Gly Asn Ala Arg Asn Ile Asn Val Tyr 
465                 470                 475                 480 


Ala Lys Glu Cys Thr Gly Leu Ala Trp Glu Trp Trp Arg Thr Val Ile 
                485                 490                 495     


Asp Asp Arg Asn Leu Pro Leu Val Lys Asn Arg Asn Ile Ser Ile Trp 
            500                 505                 510         


Gly Thr Thr Leu Tyr Pro Lys Tyr Ser Asn Lys Val Asp Asn Pro Ile 
        515                 520                 525             


Glu 
    


<210>  4
<211>  416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LLO fragment

<400>  4

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Val Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Ser Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


<210>  5
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal fragment of an ActA protein

<400>  5

Met Arg Ala Met Met Val Val Phe Ile Thr Ala Asn Cys Ile Thr Ile 
1               5                   10                  15      


Asn Pro Asp Ile Ile Phe Ala Ala Thr Asp Ser Glu Asp Ser Ser Leu 
            20                  25                  30          


Asn Thr Asp Glu Trp Glu Glu Glu Lys Thr Glu Glu Gln Pro Ser Glu 
        35                  40                  45              


Val Asn Thr Gly Pro Arg Tyr Glu Thr Ala Arg Glu Val Ser Ser Arg 
    50                  55                  60                  


Asp Ile Lys Glu Leu Glu Lys Ser Asn Lys Val Arg Asn Thr Asn Lys 
65                  70                  75                  80  


Ala Asp Leu Ile Ala Met Leu Lys Glu Lys Ala Glu Lys Gly Pro Asn 
                85                  90                  95      


Ile Asn Asn Asn Asn Ser Glu Gln Thr Glu Asn Ala Ala Ile Asn Glu 
            100                 105                 110         


Glu Ala Ser Gly Ala Asp Arg Pro Ala Ile Gln Val Glu Arg Arg His 
        115                 120                 125             


Pro Gly Leu Pro Ser Asp Ser Ala Ala Glu Ile Lys Lys Arg Arg Lys 
    130                 135                 140                 


Ala Ile Ala Ser Ser Asp Ser Glu Leu Glu Ser Leu Thr Tyr Pro Asp 
145                 150                 155                 160 


Lys Pro Thr Lys Val Asn Lys Lys Lys Val Ala Lys Glu Ser Val Ala 
                165                 170                 175     


Asp Ala Ser Glu Ser Asp Leu Asp Ser Ser Met Gln Ser Ala Asp Glu 
            180                 185                 190         


Ser Ser Pro Gln Pro Leu Lys Ala Asn Gln Gln Pro Phe Phe Pro Lys 
        195                 200                 205             


Val Phe Lys Lys Ile Lys Asp Ala Gly Lys Trp Val Arg Asp Lys Ile 
    210                 215                 220                 


Asp Glu Asn Pro Glu Val Lys Lys Ala Ile Val Asp Lys Ser Ala Gly 
225                 230                 235                 240 


Leu Ile Asp Gln Leu Leu Thr Lys Lys Lys Ser Glu Glu Val Asn Ala 
                245                 250                 255     


Ser Asp Phe Pro Pro Pro Pro Thr Asp Glu Glu Leu Arg Leu Ala Leu 
            260                 265                 270         


Pro Glu Thr Pro Met Leu Leu Gly Phe Asn Ala Pro Ala Thr Ser Glu 
        275                 280                 285             


Pro Ser Ser Phe Glu Phe Pro Pro Pro Pro Thr Asp Glu Glu Leu Arg 
    290                 295                 300                 


Leu Ala Leu Pro Glu Thr Pro Met Leu Leu Gly Phe Asn Ala Pro Ala 
305                 310                 315                 320 


Thr Ser Glu Pro Ser Ser Phe Glu Phe Pro Pro Pro Pro Thr Glu Asp 
                325                 330                 335     


Glu Leu Glu Ile Ile Arg Glu Thr Ala Ser Ser Leu Asp Ser Ser Phe 
            340                 345                 350         


Thr Arg Gly Asp Leu Ala Ser Leu Arg Asn Ala Ile Asn Arg His Ser 
        355                 360                 365             


Gln Asn Phe Ser Asp Phe Pro Pro Ile Pro Thr Glu Glu Glu Leu Asn 
    370                 375                 380                 


Gly Arg Gly Gly Arg Pro 
385                 390 


<210>  6
<211>  1170
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant nucleotide encoding a fragment of an ActA protein

<400>  6
atgcgtgcga tgatggtggt tttcattact gccaattgca ttacgattaa ccccgacata       60

atatttgcag cgacagatag cgaagattct agtctaaaca cagatgaatg ggaagaagaa      120

aaaacagaag agcaaccaag cgaggtaaat acgggaccaa gatacgaaac tgcacgtgaa      180

gtaagttcac gtgatattaa agaactagaa aaatcgaata aagtgagaaa tacgaacaaa      240

gcagacctaa tagcaatgtt gaaagaaaaa gcagaaaaag gtccaaatat caataataac      300

aacagtgaac aaactgagaa tgcggctata aatgaagagg cttcaggagc cgaccgacca      360

gctatacaag tggagcgtcg tcatccagga ttgccatcgg atagcgcagc ggaaattaaa      420

aaaagaagga aagccatagc atcatcggat agtgagcttg aaagccttac ttatccggat      480

aaaccaacaa aagtaaataa gaaaaaagtg gcgaaagagt cagttgcgga tgcttctgaa      540

agtgacttag attctagcat gcagtcagca gatgagtctt caccacaacc tttaaaagca      600

aaccaacaac catttttccc taaagtattt aaaaaaataa aagatgcggg gaaatgggta      660

cgtgataaaa tcgacgaaaa tcctgaagta aagaaagcga ttgttgataa aagtgcaggg      720

ttaattgacc aattattaac caaaaagaaa agtgaagagg taaatgcttc ggacttcccg      780

ccaccaccta cggatgaaga gttaagactt gctttgccag agacaccaat gcttcttggt      840

tttaatgctc ctgctacatc agaaccgagc tcattcgaat ttccaccacc acctacggat      900

gaagagttaa gacttgcttt gccagagacg ccaatgcttc ttggttttaa tgctcctgct      960

acatcggaac cgagctcgtt cgaatttcca ccgcctccaa cagaagatga actagaaatc     1020

atccgggaaa cagcatcctc gctagattct agttttacaa gaggggattt agctagtttg     1080

agaaatgcta ttaatcgcca tagtcaaaat ttctctgatt tcccaccaat cccaacagaa     1140

gaagagttga acgggagagg cggtagacca                                      1170


<210>  7
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEST amino acid sequence

<400>  7

Lys Thr Glu Glu Gln Pro Ser Glu Val Asn Thr Gly Pro Arg 
1               5                   10                  


<210>  8
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEST amino acid sequence

<400>  8

Lys Ala Ser Val Thr Asp Thr Ser Glu Gly Asp Leu Asp Ser Ser Met 
1               5                   10                  15      


Gln Ser Ala Asp Glu Ser Thr Pro Gln Pro Leu Lys 
            20                  25              


<210>  9
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEST amino acid sequence

<400>  9

Lys Asn Glu Glu Val Asn Ala Ser Asp Phe Pro Pro Pro Pro Thr Asp 
1               5                   10                  15      


Glu Glu Leu Arg 
            20  


<210>  10
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEST amino acid sequence

<400>  10

Arg Gly Gly Ile Pro Thr Ser Glu Glu Phe Ser Ser Leu Asn Ser Gly 
1               5                   10                  15      


Asp Phe Thr Asp Asp Glu Asn Ser Glu Thr Thr Glu Glu Glu Ile Asp 
            20                  25                  30          


Arg 
    


<210>  11
<211>  17
<212>  PRT
<213>  Streptococcus pyogenes

<400>  11

Lys Gln Asn Thr Ala Ser Thr Glu Thr Thr Thr Thr Asn Glu Gln Pro 
1               5                   10                  15      


Lys 
    


<210>  12
<211>  17
<212>  PRT
<213>  Streptococcus equisimilis

<400>  12

Lys Gln Asn Thr Ala Asn Thr Glu Thr Thr Thr Thr Asn Glu Gln Pro 
1               5                   10                  15      


Lys 
    


<210>  13
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E7 protein

<400>  13

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210>  14
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E7 protein

<400>  14

Met His Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu 
1               5                   10                  15      


Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser 
            20                  25                  30          


Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His 
        35                  40                  45              


Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met 
    50                  55                  60                  


Cys Cys Lys Cys Glu Ala Arg Ile Glu Leu Val Val Glu Ser Ser Ala 
65                  70                  75                  80  


Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe 
                85                  90                  95      


Val Cys Pro Trp Cys Ala Ser Gln Gln 
            100                 105 


<210>  15
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E6 protein

<400>  15

Met His Gln Lys Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro 
1               5                   10                  15      


Arg Lys Leu Pro Gln Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp 
            20                  25                  30          


Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu 
        35                  40                  45              


Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly 
    50                  55                  60                  


Asn Pro Tyr Ala Val Cys Asp Lys Cys Leu Lys Phe Tyr Ser Lys Ile 
65                  70                  75                  80  


Ser Glu Tyr Arg His Tyr Cys Tyr Ser Leu Tyr Gly Thr Thr Leu Glu 
                85                  90                  95      


Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu Ile Arg Cys Ile Asn 
            100                 105                 110         


Cys Gln Lys Pro Leu Cys Pro Glu Glu Lys Gln Arg His Leu Asp Lys 
        115                 120                 125             


Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr Gly Arg Cys Met 
    130                 135                 140                 


Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu 
145                 150                 155             


<210>  16
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E6 protein

<400>  16

Met Ala Arg Phe Glu Asp Pro Thr Arg Arg Pro Tyr Lys Leu Pro Asp 
1               5                   10                  15      


Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys 
            20                  25                  30          


Val Tyr Cys Lys Thr Val Leu Glu Leu Thr Glu Val Phe Glu Phe Ala 
        35                  40                  45              


Phe Lys Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro His Ala Ala 
    50                  55                  60                  


Cys His Lys Cys Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg His 
65                  70                  75                  80  


Tyr Ser Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr 
                85                  90                  95      


Gly Leu Tyr Asn Leu Leu Ile Arg Cys Leu Arg Cys Gln Lys Pro Leu 
            100                 105                 110         


Asn Pro Ala Glu Lys Leu Arg His Leu Asn Glu Lys Arg Arg Phe His 
        115                 120                 125             


Asn Ile Ala Gly His Tyr Arg Gly Gln Cys His Ser Cys Cys Asn Arg 
    130                 135                 140                 


Ala Arg Gln Glu Arg Leu Gln Arg Arg Arg Glu Thr Gln Val 
145                 150                 155             


<210>  17
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  17
ggctcgagca tggagataca cc                                                22


<210>  18
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  18
ggggactagt ttatggtttc tgagaaca                                          28


<210>  19
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  19
gggggctagc cctcctttga ttagtatatt c                                      31


<210>  20
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  20
ctccctcgag atcataattt acttcatc                                          28


<210>  21
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  21
cccgtcgacc agctcttctt ggtgaag                                           27


<210>  22
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  22
gcggatccca tggagataca cctac                                             25


<210>  23
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  23
gctctagatt atggtttctg ag                                                22


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-2Db-restricted epitope from HPV E7

<400>  24

Arg Ala His Tyr Asn Ile Val Thr Phe 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope for HIV-GAG

<400>  25

Ala Met Gln Met Leu Lys Glu Thr Ile 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope for Listeria LLO

<400>  26

Gly Tyr Lys Asp Gly Asn Glu Tyr Ile 
1               5                   


<210>  27
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  27
gactacaagg acgatgaccg acaagtgata acccgggatc taaataaatc cgttt            55


<210>  28
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  28
cctagctaaa tttaatgt                                                     18


<210>  29
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  29
cctagctaaa tttaatga                                                     18


<210>  30
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  30
taattttccc caagtagcag g                                                 21


<210>  31

<400>  31
000

<210>  32

<400>  32
000

<210>  33

<400>  33
000

<210>  34
<211>  6523
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid pAdv142

<400>  34
cggagtgtat actggcttac tatgttggca ctgatgaggg tgtcagtgaa gtgcttcatg       60

tggcaggaga aaaaaggctg caccggtgcg tcagcagaat atgtgataca ggatatattc      120

cgcttcctcg ctcactgact cgctacgctc ggtcgttcga ctgcggcgag cggaaatggc      180

ttacgaacgg ggcggagatt tcctggaaga tgccaggaag atacttaaca gggaagtgag      240

agggccgcgg caaagccgtt tttccatagg ctccgccccc ctgacaagca tcacgaaatc      300

tgacgctcaa atcagtggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc      360

cctggcggct ccctcgtgcg ctctcctgtt cctgcctttc ggtttaccgg tgtcattccg      420

ctgttatggc cgcgtttgtc tcattccacg cctgacactc agttccgggt aggcagttcg      480

ctccaagctg gactgtatgc acgaaccccc cgttcagtcc gaccgctgcg ccttatccgg      540

taactatcgt cttgagtcca acccggaaag acatgcaaaa gcaccactgg cagcagccac      600

tggtaattga tttagaggag ttagtcttga agtcatgcgc cggttaaggc taaactgaaa      660

ggacaagttt tggtgactgc gctcctccaa gccagttacc tcggttcaaa gagttggtag      720

ctcagagaac cttcgaaaaa ccgccctgca aggcggtttt ttcgttttca gagcaagaga      780

ttacgcgcag accaaaacga tctcaagaag atcatcttat taatcagata aaatatttct      840

agccctcctt tgattagtat attcctatct taaagttact tttatgtgga ggcattaaca      900

tttgttaatg acgtcaaaag gatagcaaga ctagaataaa gctataaagc aagcatataa      960

tattgcgttt catctttaga agcgaatttc gccaatatta taattatcaa aagagagggg     1020

tggcaaacgg tatttggcat tattaggtta aaaaatgtag aaggagagtg aaacccatga     1080

aaaaaataat gctagttttt attacactta tattagttag tctaccaatt gcgcaacaaa     1140

ctgaagcaaa ggatgcatct gcattcaata aagaaaattc aatttcatcc atggcaccac     1200

cagcatctcc gcctgcaagt cctaagacgc caatcgaaaa gaaacacgcg gatgaaatcg     1260

ataagtatat acaaggattg gattacaata aaaacaatgt attagtatac cacggagatg     1320

cagtgacaaa tgtgccgcca agaaaaggtt acaaagatgg aaatgaatat attgttgtgg     1380

agaaaaagaa gaaatccatc aatcaaaata atgcagacat tcaagttgtg aatgcaattt     1440

cgagcctaac ctatccaggt gctctcgtaa aagcgaattc ggaattagta gaaaatcaac     1500

cagatgttct ccctgtaaaa cgtgattcat taacactcag cattgatttg ccaggtatga     1560

ctaatcaaga caataaaata gttgtaaaaa atgccactaa atcaaacgtt aacaacgcag     1620

taaatacatt agtggaaaga tggaatgaaa aatatgctca agcttatcca aatgtaagtg     1680

caaaaattga ttatgatgac gaaatggctt acagtgaatc acaattaatt gcgaaatttg     1740

gtacagcatt taaagctgta aataatagct tgaatgtaaa cttcggcgca atcagtgaag     1800

ggaaaatgca agaagaagtc attagtttta aacaaattta ctataacgtg aatgttaatg     1860

aacctacaag accttccaga tttttcggca aagctgttac taaagagcag ttgcaagcgc     1920

ttggagtgaa tgcagaaaat cctcctgcat atatctcaag tgtggcgtat ggccgtcaag     1980

tttatttgaa attatcaact aattcccata gtactaaagt aaaagctgct tttgatgctg     2040

ccgtaagcgg aaaatctgtc tcaggtgatg tagaactaac aaatatcatc aaaaattctt     2100

ccttcaaagc cgtaatttac ggaggttccg caaaagatga agttcaaatc atcgacggca     2160

acctcggaga cttacgcgat attttgaaaa aaggcgctac ttttaatcga gaaacaccag     2220

gagttcccat tgcttataca acaaacttcc taaaagacaa tgaattagct gttattaaaa     2280

acaactcaga atatattgaa acaacttcaa aagcttatac agatggaaaa attaacatcg     2340

atcactctgg aggatacgtt gctcaattca acatttcttg ggatgaagta aattatgatc     2400

tcgagattgt gggaggctgg gagtgcgaga agcattccca accctggcag gtgcttgtgg     2460

cctctcgtgg cagggcagtc tgcggcggtg ttctggtgca cccccagtgg gtcctcacag     2520

ctgcccactg catcaggaac aaaagcgtga tcttgctggg tcggcacagc ctgtttcatc     2580

ctgaagacac aggccaggta tttcaggtca gccacagctt cccacacccg ctctacgata     2640

tgagcctcct gaagaatcga ttcctcaggc caggtgatga ctccagccac gacctcatgc     2700

tgctccgcct gtcagagcct gccgagctca cggatgctgt gaaggtcatg gacctgccca     2760

cccaggagcc agcactgggg accacctgct acgcctcagg ctggggcagc attgaaccag     2820

aggagttctt gaccccaaag aaacttcagt gtgtggacct ccatgttatt tccaatgacg     2880

tgtgtgcgca agttcaccct cagaaggtga ccaagttcat gctgtgtgct ggacgctgga     2940

cagggggcaa aagcacctgc tcgggtgatt ctgggggccc acttgtctgt tatggtgtgc     3000

ttcaaggtat cacgtcatgg ggcagtgaac catgtgccct gcccgaaagg ccttccctgt     3060

acaccaaggt ggtgcattac cggaagtgga tcaaggacac catcgtggcc aacccctaac     3120

ccgggccact aactcaacgc tagtagtgga tttaatccca aatgagccaa cagaaccaga     3180

accagaaaca gaacaagtaa cattggagtt agaaatggaa gaagaaaaaa gcaatgattt     3240

cgtgtgaata atgcacgaaa tcattgctta tttttttaaa aagcgatata ctagatataa     3300

cgaaacaacg aactgaataa agaatacaaa aaaagagcca cgaccagtta aagcctgaga     3360

aactttaact gcgagcctta attgattacc accaatcaat taaagaagtc gagacccaaa     3420

atttggtaaa gtatttaatt actttattaa tcagatactt aaatatctgt aaacccatta     3480

tatcgggttt ttgaggggat ttcaagtctt taagaagata ccaggcaatc aattaagaaa     3540

aacttagttg attgcctttt ttgttgtgat tcaactttga tcgtagcttc taactaatta     3600

attttcgtaa gaaaggagaa cagctgaatg aatatccctt ttgttgtaga aactgtgctt     3660

catgacggct tgttaaagta caaatttaaa aatagtaaaa ttcgctcaat cactaccaag     3720

ccaggtaaaa gtaaaggggc tatttttgcg tatcgctcaa aaaaaagcat gattggcgga     3780

cgtggcgttg ttctgacttc cgaagaagcg attcacgaaa atcaagatac atttacgcat     3840

tggacaccaa acgtttatcg ttatggtacg tatgcagacg aaaaccgttc atacactaaa     3900

ggacattctg aaaacaattt aagacaaatc aataccttct ttattgattt tgatattcac     3960

acggaaaaag aaactatttc agcaagcgat attttaacaa cagctattga tttaggtttt     4020

atgcctacgt taattatcaa atctgataaa ggttatcaag catattttgt tttagaaacg     4080

ccagtctatg tgacttcaaa atcagaattt aaatctgtca aagcagccaa aataatctcg     4140

caaaatatcc gagaatattt tggaaagtct ttgccagttg atctaacgtg caatcatttt     4200

gggattgctc gtataccaag aacggacaat gtagaatttt ttgatcccaa ttaccgttat     4260

tctttcaaag aatggcaaga ttggtctttc aaacaaacag ataataaggg ctttactcgt     4320

tcaagtctaa cggttttaag cggtacagaa ggcaaaaaac aagtagatga accctggttt     4380

aatctcttat tgcacgaaac gaaattttca ggagaaaagg gtttagtagg gcgcaatagc     4440

gttatgttta ccctctcttt agcctacttt agttcaggct attcaatcga aacgtgcgaa     4500

tataatatgt ttgagtttaa taatcgatta gatcaaccct tagaagaaaa agaagtaatc     4560

aaaattgtta gaagtgccta ttcagaaaac tatcaagggg ctaataggga atacattacc     4620

attctttgca aagcttgggt atcaagtgat ttaaccagta aagatttatt tgtccgtcaa     4680

gggtggttta aattcaagaa aaaaagaagc gaacgtcaac gtgttcattt gtcagaatgg     4740

aaagaagatt taatggctta tattagcgaa aaaagcgatg tatacaagcc ttatttagcg     4800

acgaccaaaa aagagattag agaagtgcta ggcattcctg aacggacatt agataaattg     4860

ctgaaggtac tgaaggcgaa tcaggaaatt ttctttaaga ttaaaccagg aagaaatggt     4920

ggcattcaac ttgctagtgt taaatcattg ttgctatcga tcattaaatt aaaaaaagaa     4980

gaacgagaaa gctatataaa ggcgctgaca gcttcgttta atttagaacg tacatttatt     5040

caagaaactc taaacaaatt ggcagaacgc cccaaaacgg acccacaact cgatttgttt     5100

agctacgata caggctgaaa ataaaacccg cactatgcca ttacatttat atctatgata     5160

cgtgtttgtt tttctttgct ggctagctta attgcttata tttacctgca ataaaggatt     5220

tcttacttcc attatactcc cattttccaa aaacatacgg ggaacacggg aacttattgt     5280

acaggccacc tcatagttaa tggtttcgag ccttcctgca atctcatcca tggaaatata     5340

ttcatccccc tgccggccta ttaatgtgac ttttgtgccc ggcggatatt cctgatccag     5400

ctccaccata aattggtcca tgcaaattcg gccggcaatt ttcaggcgtt ttcccttcac     5460

aaggatgtcg gtccctttca attttcggag ccagccgtcc gcatagccta caggcaccgt     5520

cccgatccat gtgtcttttt ccgctgtgta ctcggctccg tagctgacgc tctcgccttt     5580

tctgatcagt ttgacatgtg acagtgtcga atgcagggta aatgccggac gcagctgaaa     5640

cggtatctcg tccgacatgt cagcagacgg gcgaaggcca tacatgccga tgccgaatct     5700

gactgcatta aaaaagcctt ttttcagccg gagtccagcg gcgctgttcg cgcagtggac     5760

cattagattc tttaacggca gcggagcaat cagctcttta aagcgctcaa actgcattaa     5820

gaaatagcct ctttcttttt catccgctgt cgcaaaatgg gtaaataccc ctttgcactt     5880

taaacgaggg ttgcggtcaa gaattgccat cacgttctga acttcttcct ctgtttttac     5940

accaagtctg ttcatccccg tatcgacctt cagatgaaaa tgaagagaac cttttttcgt     6000

gtggcgggct gcctcctgaa gccattcaac agaataacct gttaaggtca cgtcatactc     6060

agcagcgatt gccacatact ccgggggaac cgcgccaagc accaatatag gcgccttcaa     6120

tccctttttg cgcagtgaaa tcgcttcatc caaaatggcc acggccaagc atgaagcacc     6180

tgcgtcaaga gcagcctttg ctgtttctgc atcaccatgc ccgtaggcgt ttgctttcac     6240

aactgccatc aagtggacat gttcaccgat atgttttttc atattgctga cattttcctt     6300

tatcgcggac aagtcaattt ccgcccacgt atctctgtaa aaaggttttg tgctcatgga     6360

aaactcctct cttttttcag aaaatcccag tacgtaatta agtatttgag aattaatttt     6420

atattgatta atactaagtt tacccagttt tcacctaaaa aacaaatgat gagataatag     6480

ctccaaaggc taaagaggac tataccaact atttgttaat taa                       6523


<210>  35
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  35
cggaattcgg atccgcgcca aatcattggt tgattg                                 36


<210>  36
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  36
gcgagtcgac gtcggggtta atcgtaatgc aattggc                                37


<210>  37
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  37
gcgagtcgac ccatacgacg ttaattcttg caatg                                  35


<210>  38
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  38
gatactgcag ggatccttcc cttctcggta atcagtcac                              39


<210>  39
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  39
tgggatggcc aagaaattc                                                    19


<210>  40
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  40
ctaccatgtc ttccgttgct tg                                                22


<210>  41
<211>  364
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lovaxin_C_pGG55

<400>  41
ccaaacccta caaaaacaag tttcatacag cctagctaaa tttaatgttt tttcgattaa       60

cgggaagctt ggctctattt gcggtcaact tttaatcctg acctatgtgt atggtaaaga      120

aactcctgat ggcatcaaga ttacactgga taatttaaca atgcaggagt taggatattc      180

aagtggcatc gcacatagct cagctgttag cagaattatt tccaaattaa agcaagagaa      240

agttatcgtg tataaaaatt catgctttta tgtacaaaat cgtgattatc tcaaaagata      300

tgcccctaaa ttagatgaat ggttttattt agcatgtcct gctacttggg gaaaattaaa      360

ttaa                                                                   364


<210>  42
<211>  364
<212>  DNA
<213>  Listeria monocytogenes

<400>  42
ccaaacccta caaaaacaag tttcatacag cctagctaaa tttaatgatt tttcgattaa       60

cgggaagctt ggctctattt gcggtcaact tttaatcctg acctatgtgt atggtaaaga      120

aactcctgat ggcatcaaga ttacactgga taatttaaca atgcaggagt taggatattc      180

aagtggcatc gcacatagct cagctgttag cagaattatt tccaaattaa agcaagagaa      240

agttatcgtg tataaaaatt catgctttta tgtacaaaat cttgattatc tcaaaagata      300

tgcccctaaa ttagatgaat ggttttattt agcatgtcct gctacttggg gaaaattaaa      360

ttaa                                                                   364


