                         SEQUENCE LISTING

<110>  Arbutus Biopharma, Inc.
       Protiva Biotherapeutics, Inc.
 
<120>  Substituted Pyridinone-Containing Tricyclic Compounds, and 
       Methods Using Same

<130>  367569-7004WO1(00021)

<150>  US 62/512,990
<151>  2017-05-31

<150>  US 62/506,325
<151>  2017-05-15

<150>  US 62/418,478
<151>  2016-11-07

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  unlocked nucleobase analogue (UNA) moiety

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  unlocked nucleobase analogue (UNA) moiety

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  unlocked nucleobase analogue (UNA) moiety

<400>  1
ccgugugcac uucgcuucau u                                                 21


<210>  2
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized


<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  unlocked nucleobase analogue (UNA) moiety

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  unlocked nucleobase analogue (UNA) moiety

<400>  2
ugaagcgaag ugcacacggu u                                                 21


<210>  3
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  unlocked nucleobase analogue (UNA) moeity

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  unlocked nucleobase analogue (UNA) moeity

<400>  3
cuggcucagu uuacuagugu u                                                 21


<210>  4
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized


<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modification

<400>  4
cacuaguaaa cugagccagu u                                                 21


<210>  5
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  unlocked nucleobase analogue (UNA) moiety

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  unlocked nucleobase analogue (UNA) moiety

<400>  5
gccgauccau acugcggaau u                                                 21


<210>  6
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized


<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modification

<400>  6
uuccgcagua uggaucggcu u                                                 21


<210>  7
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized


<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modification

<400>  7
ccgugugcac uucgcuucau u                                                 21


<210>  8
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized


<220>
<221>  modified_base
<222>  (5)..(5)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modification

<400>  8
ugaagcgaag ugcacacggu u                                                 21


<210>  9
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized


<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  2'-O-methyl modification

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  2'-O-methyl modification

<400>  9
cuggcucagu uuacuagugu u                                                 21


<210>  10
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized


<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methoxy modification

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methoxy modification

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  2'-O-methoxy modification

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methoxy modification

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methoxy modification

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methoxy modification

<400>  10
cacuaguaaa cugagccagu u                                                 21


<210>  11
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized


<220>
<221>  modified_base
<222>  (2)..(2)
<223>  2'-O-methoxy modification

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  2'-O-methoxy modification

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  2'-O-methoxy modification

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  2'-O-methoxy modification

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  2'-O-methoxy modification

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  2'-O-methoxy modification

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  2'-O-methoxy modification

<400>  11
accucugccu aaucaucucu u                                                 21


<210>  12
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized


<220>
<221>  modified_base
<222>  (7)..(7)
<223>  2'-O-methoxy modification

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  2'-O-methoxy modification

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  2'-O-methoxy modification

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  2'-O-methoxy modification

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  2'-O-methoxy modification

<400>  12
gagaugauua ggcagagguu u                                                 21


