
                                SEQUENCE LISTING

<110> Helix Biomedix, Inc.
      Zhang, Lijuan
      Carmichael, Robin

<120> SHORT BIOACTIVE PEPTIDES BLOCKING
  ACTIVITY OF ADVANCED GLYCATION END PRODUCTS, COMPOSITIONS,
  AND METHODS OF USE

<130> 150145.404WO

<140> PCT                 
<141> 2017-10-24  

<150> US 62/417,137  
<151> 2016-11-03

<160> 61

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2210

<220>
<221> AMIDATION      
<222> 5

<400> 1
Lys Gly Ala Pro Lys
 1               5

<210> 2
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2211

<220>
<221> AMIDATION      
<222> 6

<400> 2
Pro Lys Lys Pro Pro Gln
 1               5

<210> 3
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2212

<220>
<221> AMIDATION      
<222> 7

<400> 3
Pro Gln Arg Leu Glu Trp Lys
 1               5

<210> 4
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2213

<220>
<221> AMIDATION      
<222> 9

<400> 4
Leu Glu Trp Lys Leu Asn Thr Gly Arg
 1               5

<210> 5
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2214

<220>
<221> AMIDATION      
<222> 6

<400> 5
Thr Gly Arg Thr Glu Ala
 1               5

<210> 6
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2215

<220>
<221> AMIDATION      
<222> 7

<400> 6
Thr Glu Ala Trp Lys Val Lys
 1               5

<210> 7
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2216

<220>
<221> AMIDATION      
<222> 8

<400> 7
Ala Trp Lys Val Lys Ser Pro Gln
 1               5

<210> 8
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2217

<220>
<221> AMIDATION      
<222> 7

<400> 8
Ser Pro Gln Gly Gly Gly Pro
 1               5

<210> 9
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2218

<220>
<221> AMIDATION      
<222> 7

<400> 9
Gly Pro Trp Asp Ser Val Arg
 1               5

<210> 10
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2219

<220>
<221> AMIDATION      
<222> 5

<400> 10
Pro Trp Asp Ser Val
 1               5

<210> 11
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2220

<220>
<221> AMIDATION      
<222> 6

<400> 11
Arg Val Leu Pro Asn Gly
 1               5

<210> 12
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2221

<220>
<221> AMIDATION      
<222> 5

<400> 12
Ser Leu Phe Leu Pro
 1               5

<210> 13
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2289

<220>
<221> MOD_RES        
<222> 5
<223> Free acid (OH)

<400> 13
Ser Leu Phe Leu Pro
 1               5

<210> 14
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2222

<220>
<221> AMIDATION      
<222> 5

<400> 14
Asn Ser Leu Phe Leu
 1               5

<210> 15
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2223

<220>
<221> AMIDATION      
<222> 6

<400> 15
Phe Leu Pro Ala Val Gly
 1               5

<210> 16
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2224

<220>
<221> AMIDATION      
<222> 7

<400> 16
Val Gly Ile Gln Asn Glu Gly
 1               5

<210> 17
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2225

<220>
<221> AMIDATION      
<222> 7

<400> 17
Gln Asn Glu Gly Ile Phe Arg
 1               5

<210> 18
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2275

<220>
<221> MOD_RES        
<222> 4
<223> Free acid (OH)

<400> 18
Ser Leu Phe Leu
 1

<210> 19
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2303

<220>
<221> AMIDATION      
<222> 4

<400> 19
Ser Leu Phe Leu
 1

<210> 20
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2277

<220>
<221> MOD_RES        
<222> 4
<223> Free acid (OH)

<400> 20
Leu Phe Leu Pro
 1

<210> 21
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2278

<220>
<221> MOD_RES        
<222> 4
<223> Free acid (OH)

<400> 21
Val Gly Ile Gln
 1

<210> 22
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2302

<220>
<221> AMIDATION      
<222> 4

<400> 22
Val Gly Ile Gln
 1

<210> 23
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2281

<220>
<221> MOD_RES        
<222> 4
<223> Free acid (OH)

<400> 23
Gly Ala Pro Lys
 1

<210> 24
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2305

<220>
<221> AMIDATION      
<222> 4

<400> 24
Gly Ala Pro Lys
 1

<210> 25
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2282

<220>
<221> MOD_RES        
<222> 4
<223> Free acid (OH)

<400> 25
Ser Pro Gln Gly
 1

<210> 26
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2298

<220>
<221> AMIDATION      
<222> 4

<400> 26
Ser Pro Gln Gly
 1

<210> 27
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2283

<220>
<221> MOD_RES        
<222> 4
<223> Free acid (OH)

<400> 27
Leu Glu Trp Lys
 1

<210> 28
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2306

<220>
<221> AMIDATION      
<222> 4

<400> 28
Leu Glu Trp Lys
 1

<210> 29
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2288

<220>
<221> MOD_RES        
<222> 4
<223> Free acid (OH)

<400> 29
Lys Gly Ala Pro
 1

<210> 30
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2309

<220>
<221> AMIDATION      
<222> 4

<400> 30
Lys Gly Ala Pro
 1

<210> 31
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2291

<220>
<221> MOD_RES        
<222> 4
<223> Free acid (OH)

<400> 31
Gly Gly Gly Pro
 1

<210> 32
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2295

<220>
<221> MOD_RES        
<222> 4
<223> Free acid (OH)

<400> 32
Thr Gly Arg Thr
 1

<210> 33
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2311

<220>
<221> AMIDATION      
<222> 4

<400> 33
Thr Gly Arg Thr
 1

<210> 34
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2313

<220>
<221> MOD_RES        
<222> 4
<223> Free acid (OH)

<400> 34
Glu Trp Lys Leu
 1

<210> 35
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2321

<220>
<221> MOD_RES        
<222> 4
<223> Free acid (OH)

<400> 35
Gly Pro Trp Asp
 1

<210> 36
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2322

<220>
<221> AMIDATION      
<222> 4

<400> 36
Gly Pro Trp Asp
 1

<210> 37
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2276

<220>
<221> MOD_RES        
<222> 3
<223> Free acid (OH)

<400> 37
Phe Leu Pro
 1

<210> 38
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2304

<220>
<221> AMIDATION      
<222> 3

<400> 38
Phe Leu Pro
 1

<210> 39
<211> 2
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2285

<220>
<221> MOD_RES        
<222> 2
<223> Free acid (OH)

<400> 39
Leu Pro
 1

<210> 40
<211> 2
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2307

<220>
<221> AMIDATION      
<222> 2

<400> 40
Leu Pro
 1

<210> 41
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2290

<220>
<221> MOD_RES        
<222> 3
<223> Free acid (OH)

<400> 41
Gly Gly Pro
 1

<210> 42
<211> 2
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2286

<220>
<221> MOD_RES        
<222> 2
<223> Free acid (OH)

<400> 42
Phe Leu
 1

<210> 43
<211> 2
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2308

<220>
<221> AMIDATION      
<222> 2

<400> 43
Phe Leu
 1

<210> 44
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2293

<220>
<221> MOD_RES        
<222> 3
<223> Free acid (OH)

<400> 44
Gly Arg Thr
 1

<210> 45
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2310


<220>
<221> AMIDATION      
<222> 3

<400> 45
Gly Arg Thr
 1

<210> 46
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2296

<220>
<221> MOD_RES        
<222> 3
<223> Free acid (OH)

<400> 46
Ser Pro Gln
 1

<210> 47
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2297

<220>
<221> AMIDATION      
<222> 3

<400> 47
Ser Pro Gln
 1

<210> 48
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2292

<220>
<221> MOD_RES        
<222> 3
<223> Free acid (OH)

<400> 48
Ser Pro Gly
 1

<210> 49
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2294

<220>
<221> MOD_RES        
<222> 3
<223> Free acid (OH)

<400> 49
Thr Gly Arg
 1

<210> 50
<211> 2
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic peptide HB2287

<220>
<221> MOD_RES        
<222> 2
<223> Free acid (OH)

<400> 50
Gly Pro
 1

<210> 51

<220> 
<223> Synthetic peptide HB2314

<220>
<221> AMIDATION      
<222> 2

<400> 51
 000

<210> 52
<211> 2
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2299

<220>
<221> MOD_RES        
<222> 2
<223> Free acid (OH)

<400> 52
Ser Pro
 1

<210> 53
<211> 2
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2300

<220>
<221> AMIDATION      
<222> 2

<400> 53
Ser Pro
 1

<210> 54
<211> 2
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2315

<220>
<221> AMIDATION      
<222> 2

<400> 54
Thr Gly
 1

<210> 55
<211> 2
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2316

<220>
<221> MOD_RES        
<222> 2
<223> Free acid (OH)

<400> 55
Thr Gly
 1

<210> 56
<211> 2
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2317

<220>
<221> AMIDATION      
<222> 2

<400> 56
Pro Gln
 1

<210> 57
<211> 2
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2319

<220>
<221> MOD_RES        
<222> 2
<223> Free acid (OH)

<400> 57
Pro Gln
 1

<210> 58
<211> 2
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2320

<220>
<221> AMIDATION      
<222> 2

<400> 58
Arg Thr
 1

<210> 59
<211> 2
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic peptide HB2318

<220>
<221> MOD_RES        
<222> 2
<223> Free acid (OH)

<400> 59
Arg Thr
 1

<210> 60
<211> 404
<212> PRT
<213> Homo sapiens

<400> 60
Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu
 1               5                  10                  15
Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu
            20                  25                  30
Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg
        35                  40                  45
Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu
    50                  55                  60
Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro
65                  70                  75                  80
Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile
                85                  90                  95
Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn
            100                 105                 110
Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp
        115                 120                 125
Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys
    130                 135                 140
Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp
145                 150                 155                 160
Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln
                165                 170                 175
Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu
            180                 185                 190
Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys
        195                 200                 205
Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro
    210                 215                 220
Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu
225                 230                 235                 240
Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr
                245                 250                 255
Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met
            260                 265                 270
Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu
        275                 280                 285
Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr
    290                 295                 300
His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile
305                 310                 315                 320
Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val Gly Gly Ser
                325                 330                 335
Gly Leu Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly
            340                 345                 350
Thr Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg Gln Arg
        355                 360                 365
Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu Glu
    370                 375                 380
Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu Ala Gly Glu Ser Ser
385                 390                 395                 400
Thr Gly Gly Pro


<210> 61
<211> 77
<212> PRT
<213> Homo sapiens

<400> 61
Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu Trp Lys Leu Asn
 1               5                  10                  15
Thr Gly Arg Thr Glu Ala Trp Lys Val Leu Ser Pro Gln Gly Gly Gly
            20                  25                  30
Pro Trp Asp Ser Val Ala Arg Val Leu Pro Asn Gly Ser Leu Phe Leu
        35                  40                  45
Pro Ala Val Gly Ile Gln Asp Glu Gly Ile Phe Arg Cys Gln Ala Met
    50                  55                  60
Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg Val
65                  70                  75