                         SEQUENCE LISTING

<110>  DEBIOPHARM INTERNATIONAL, S.A.
 
<120>  Methods for Improving Anti-CD37 Immunoconjugate Therapy

<130>  4018.005PC01

<150>  62/416,376
<151>  2016-11-02

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  281
<212>  PRT
<213>  Homo Sapiens

<400>  1

Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Ser Leu Ile Phe Cys Phe 
            20                  25                  30          


Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly 
        35                  40                  45              


Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile Ser 
    50                  55                  60                  


Gly Ile Phe Thr Met Gly Ile Ala Leu Leu Gly Cys Val Gly Ala Leu 
65                  70                  75                  80  


Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu 
                85                  90                  95      


Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg 
            100                 105                 110         


Ala Gln Leu Glu Arg Ser Leu Arg Asp Val Val Glu Lys Thr Ile Gln 
        115                 120                 125             


Lys Tyr Gly Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp Asp 
    130                 135                 140                 


Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Tyr Pro Gln Asp 
145                 150                 155                 160 


Trp Phe Gln Val Leu Ile Leu Arg Gly Asn Gly Ser Glu Ala His Arg 
                165                 170                 175     


Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr Ile 
            180                 185                 190         


Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly His Leu Ala 
        195                 200                 205             


Arg Ser Arg His Ser Ala Asp Ile Cys Ala Val Pro Ala Glu Ser His 
    210                 215                 220                 


Ile Tyr Arg Glu Gly Cys Ala Gln Gly Leu Gln Lys Trp Leu His Asn 
225                 230                 235                 240 


Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu 
                245                 250                 255     


Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His 
            260                 265                 270         


Val Tyr Asn Arg Leu Ala Arg Tyr Arg 
        275                 280     


<210>  2
<211>  281
<212>  PRT
<213>  Macaca mulatta

<400>  2

Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Ile Leu Gly Ser Leu Ile Phe Cys 
            20                  25                  30          


Phe Gly Ile Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val 
        35                  40                  45              


Gly Leu Ala Phe Val Pro Leu Gln Ile Trp Ser Lys Val Leu Ala Ile 
    50                  55                  60                  


Ser Gly Val Phe Thr Met Gly Leu Ala Leu Leu Gly Cys Val Gly Ala 
65                  70                  75                  80  


Leu Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu 
                85                  90                  95      


Leu Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln 
            100                 105                 110         


Arg Ala Gln Leu Glu Arg Ser Leu Gln Asp Ile Val Glu Lys Thr Ile 
        115                 120                 125             


Gln Arg Tyr His Thr Asn Pro Glu Glu Thr Ala Ala Glu Glu Ser Trp 
    130                 135                 140                 


Asp Tyr Val Gln Phe Gln Leu Arg Cys Cys Gly Trp His Ser Pro Gln 
145                 150                 155                 160 


Asp Trp Phe Gln Val Leu Thr Leu Arg Gly Asn Gly Ser Glu Ala His 
                165                 170                 175     


Arg Val Pro Cys Ser Cys Tyr Asn Leu Ser Ala Thr Asn Asp Ser Thr 
            180                 185                 190         


Ile Leu Asp Lys Val Ile Leu Pro Gln Leu Ser Arg Leu Gly Gln Leu 
        195                 200                 205             


Ala Arg Ser Arg His Ser Thr Asp Ile Cys Ala Val Pro Ala Asn Ser 
    210                 215                 220                 


His Ile Tyr Arg Glu Gly Cys Ala Arg Ser Leu Gln Lys Trp Leu His 
225                 230                 235                 240 


Asn Asn Leu Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu 
                245                 250                 255     


Glu Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp 
            260                 265                 270         


His Val Tyr Asn Arg Leu Arg Tyr Arg 
        275                 280     


<210>  3
<211>  281
<212>  PRT
<213>  Mus musculus

<400>  3

Met Ser Ala Gln Glu Ser Cys Leu Ser Leu Ile Lys Tyr Phe Leu Phe 
1               5                   10                  15      


Val Phe Asn Leu Phe Phe Phe Val Leu Gly Gly Leu Ile Phe Cys Phe 
            20                  25                  30          


Gly Thr Trp Ile Leu Ile Asp Lys Thr Ser Phe Val Ser Phe Val Gly 
        35                  40                  45              


Leu Ser Phe Val Pro Leu Gln Thr Trp Ser Lys Val Leu Ala Val Ser 
    50                  55                  60                  


Gly Val Leu Thr Met Ala Leu Ala Leu Leu Gly Cys Val Gly Ala Leu 
65                  70                  75                  80  


Lys Glu Leu Arg Cys Leu Leu Gly Leu Tyr Phe Gly Met Leu Leu Leu 
                85                  90                  95      


Leu Phe Ala Thr Gln Ile Thr Leu Gly Ile Leu Ile Ser Thr Gln Arg 
            100                 105                 110         


Val Arg Leu Glu Arg Arg Val Gln Glu Leu Val Leu Arg Thr Ile Gln 
        115                 120                 125             


Ser Tyr Arg Thr Asn Pro Asp Glu Thr Ala Ala Glu Glu Ser Trp Asp 
    130                 135                 140                 


Tyr Ala Gln Phe Gln Leu Arg Cys Cys Gly Trp Gln Ser Pro Arg Asp 
145                 150                 155                 160 


Trp Asn Lys Ala Gln Met Leu Lys Ala Asn Glu Ser Glu Glu Pro Phe 
                165                 170                 175     


Val Pro Cys Ser Cys Tyr Asn Ser Thr Ala Thr Asn Asp Ser Thr Val 
            180                 185                 190         


Phe Asp Lys Leu Phe Phe Ser Gln Leu Ser Arg Leu Gly Pro Arg Ala 
        195                 200                 205             


Lys Leu Arg Gln Thr Ala Asp Ile Cys Ala Leu Pro Ala Lys Ala His 
    210                 215                 220                 


Ile Tyr Arg Glu Gly Cys Ala Gln Ser Leu Gln Lys Trp Leu His Asn 
225                 230                 235                 240 


Asn Ile Ile Ser Ile Val Gly Ile Cys Leu Gly Val Gly Leu Leu Glu 
                245                 250                 255     


Leu Gly Phe Met Thr Leu Ser Ile Phe Leu Cys Arg Asn Leu Asp His 
            260                 265                 270         


Val Tyr Asp Arg Leu Ala Arg Tyr Arg 
        275                 280     


<210>  4
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH-CDR1

<400>  4

Thr Ser Gly Val Ser 
1               5   


<210>  5
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH-CDR2

<400>  5

Val Ile Trp Gly Asp Gly Ser Thr Asn 
1               5                   


<210>  6
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH-CDR3

<400>  6

Gly Gly Tyr Ser Leu Ala His 
1               5           


<210>  7
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL-CDR1

<400>  7

Arg Ala Ser Glu Asn Ile Arg Ser Asn Leu Ala 
1               5                   10      


<210>  8
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL-CDR2

<400>  8

Val Ala Thr Asn Leu Ala Asp 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL-CDR3

<400>  9

Gln His Tyr Trp Gly Thr Thr Trp Thr 
1               5                   


<210>  10
<211>  115
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH muCD37-3

<400>  10

Gln Val Gln Val Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Ser 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Lys Lys Asp His Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Gln Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Gly Tyr Ser Leu Ala His Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  11
<211>  115
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH chCD37-3

<400>  11

Gln Val Gln Val Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Ser 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Lys Lys Asp His Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Gln Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Gly Tyr Ser Leu Ala His Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  12
<211>  115
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH huCD37-3 (version 1.0)

<400>  12

Gln Val Gln Val Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Ser 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Lys Lys Asp His Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Gly Tyr Ser Leu Ala His Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  13
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL muCD37-3

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Arg Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Asn Val Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Tyr Trp Gly Thr Thr Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  14
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL chCD37-3

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Arg Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Asn Val Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Tyr Trp Gly Thr Thr Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  15
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL huCD37-3

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Arg Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Val 
        35                  40                  45              


Asn Val Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Tyr Trp Gly Thr Thr Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  16
<211>  445
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain muCD37-3

<400>  16

Gln Val Gln Val Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Ser 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Lys Lys Asp His Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Gln Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Gly Tyr Ser Leu Ala His Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
                165                 170                 175     


Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser 
            180                 185                 190         


Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro 
    210                 215                 220                 


Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile 
225                 230                 235                 240 


Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln 
            260                 265                 270         


Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln 
        275                 280                 285             


Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu 
    290                 295                 300                 


Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys 
305                 310                 315                 320 


Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys 
                325                 330                 335     


Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro 
            340                 345                 350         


Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr 
        355                 360                 365             


Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys 
    370                 375                 380                 


Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val 
                405                 410                 415     


Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn 
            420                 425                 430         


His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
        435                 440                 445 


<210>  17
<211>  445
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain chCD37-3

<400>  17

Gln Val Gln Val Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Ser 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Lys Lys Asp His Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Gln Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Gly Tyr Ser Leu Ala His Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  18
<211>  444
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy chain huCD37-3

<400>  18

Gln Val Gln Val Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Ser 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Lys Lys Asp His Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Gly Tyr Ser Leu Ala His Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 


<210>  19
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain muCD37-3

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Arg Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Asn Val Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Tyr Trp Gly Thr Thr Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  20
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain chCD37-3

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Arg Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Asn Val Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Tyr Trp Gly Thr Thr Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  21
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain huCD37-3

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Arg Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Val 
        35                  40                  45              


Asn Val Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Tyr Trp Gly Thr Thr Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  22
<211>  115
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH huCD37-3 (version 1.1)

<400>  22

Gln Val Gln Val Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Thr Ser 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Ser Thr Asn Tyr His Ser Ser Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Lys Lys Asp His Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Gly Tyr Ser Leu Ala His Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  23
<211>  742
<212>  PRT
<213>  Homo Sapiens

<400>  23

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     


Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             


Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 
    690                 695                 700                 


Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr 
705                 710                 715                 720 


Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val 
                725                 730                 735     


Asp Met Lys Ile Gly Val 
            740         


<210>  24
<211>  466
<212>  PRT
<213>  Homo Sapiens

<400>  24

Met Ser Thr Arg Ser Val Ser Ser Ser Ser Tyr Arg Arg Met Phe Gly 
1               5                   10                  15      


Gly Pro Gly Thr Ala Ser Arg Pro Ser Ser Ser Arg Ser Tyr Val Thr 
            20                  25                  30          


Thr Ser Thr Arg Thr Tyr Ser Leu Gly Ser Ala Leu Arg Pro Ser Thr 
        35                  40                  45              


Ser Arg Ser Leu Tyr Ala Ser Ser Pro Gly Gly Val Tyr Ala Thr Arg 
    50                  55                  60                  


Ser Ser Ala Val Arg Leu Arg Ser Ser Val Pro Gly Val Arg Leu Leu 
65                  70                  75                  80  


Gln Asp Ser Val Asp Phe Ser Leu Ala Asp Ala Ile Asn Thr Glu Phe 
                85                  90                  95      


Lys Asn Thr Arg Thr Asn Glu Lys Val Glu Leu Gln Glu Leu Asn Asp 
            100                 105                 110         


Arg Phe Ala Asn Tyr Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn 
        115                 120                 125             


Lys Ile Leu Leu Ala Glu Leu Glu Gln Leu Lys Gly Gln Gly Lys Ser 
    130                 135                 140                 


Arg Leu Gly Asp Leu Tyr Glu Glu Glu Met Arg Glu Leu Arg Arg Gln 
145                 150                 155                 160 


Val Asp Gln Leu Thr Asn Asp Lys Ala Arg Val Glu Val Glu Arg Asp 
                165                 170                 175     


Asn Leu Ala Glu Asp Ile Met Arg Leu Arg Glu Lys Leu Gln Glu Glu 
            180                 185                 190         


Met Leu Gln Arg Glu Glu Ala Glu Asn Thr Leu Gln Ser Phe Arg Gln 
        195                 200                 205             


Asp Val Asp Asn Ala Ser Leu Ala Arg Leu Asp Leu Glu Arg Lys Val 
    210                 215                 220                 


Glu Ser Leu Gln Glu Glu Ile Ala Phe Leu Lys Lys Leu His Glu Glu 
225                 230                 235                 240 


Glu Ile Gln Glu Leu Gln Ala Gln Ile Gln Glu Gln His Val Gln Ile 
                245                 250                 255     


Asp Val Asp Val Ser Lys Pro Asp Leu Thr Ala Ala Leu Arg Asp Val 
            260                 265                 270         


Arg Gln Gln Tyr Glu Ser Val Ala Ala Lys Asn Leu Gln Glu Ala Glu 
        275                 280                 285             


Glu Trp Tyr Lys Ser Lys Phe Ala Asp Leu Ser Glu Ala Ala Asn Arg 
    290                 295                 300                 


Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu Ser Thr Glu Tyr Arg 
305                 310                 315                 320 


Arg Gln Val Gln Ser Leu Thr Cys Glu Val Asp Ala Leu Lys Gly Thr 
                325                 330                 335     


Asn Glu Ser Leu Glu Arg Gln Met Arg Glu Met Glu Glu Asn Phe Ala 
            340                 345                 350         


Val Glu Ala Ala Asn Tyr Gln Asp Thr Ile Gly Arg Leu Gln Asp Glu 
        355                 360                 365             


Ile Gln Asn Met Lys Glu Glu Met Ala Arg His Leu Arg Glu Tyr Gln 
    370                 375                 380                 


Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala Thr Tyr 
385                 390                 395                 400 


Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile Ser Leu Pro Leu Pro 
                405                 410                 415     


Asn Phe Ser Ser Leu Asn Leu Arg Glu Thr Asn Leu Asp Ser Leu Pro 
            420                 425                 430         


Leu Val Asp Thr His Ser Lys Arg Thr Leu Leu Ile Lys Thr Val Glu 
        435                 440                 445             


Thr Arg Asp Gly Gln Val Ile Asn Glu Thr Ser Gln His His Asp Asp 
    450                 455                 460                 


Leu Glu 
465     


<210>  25
<211>  339
<212>  PRT
<213>  Homo Sapiens

<400>  25

Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp 
1               5                   10                  15      


His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn 
            20                  25                  30          


Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr 
        35                  40                  45              


Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser 
    50                  55                  60                  


Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys 
65                  70                  75                  80  


Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu 
                85                  90                  95      


Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser 
            100                 105                 110         


Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu 
        115                 120                 125             


Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn 
    130                 135                 140                 


Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile 
145                 150                 155                 160 


Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys 
                165                 170                 175     


Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp 
            180                 185                 190         


Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr 
        195                 200                 205             


Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His 
    210                 215                 220                 


Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met 
225                 230                 235                 240 


Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe 
                245                 250                 255     


Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp 
            260                 265                 270         


Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu 
        275                 280                 285             


Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg 
    290                 295                 300                 


Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln 
305                 310                 315                 320 


Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly 
                325                 330                 335     


Gly Asp Asp 
            


<210>  26
<211>  239
<212>  PRT
<213>  Homo Sapiens

<400>  26

Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Pro 
        195                 200                 205             


Leu Phe Asp Phe Ser Trp Leu Ser Leu Lys Thr Leu Leu Ser Leu Ala 
    210                 215                 220                 


Leu Val Gly Ala Cys Ile Thr Leu Gly Ala Tyr Leu Gly His Lys 
225                 230                 235                 


<210>  27
<211>  339
<212>  PRT
<213>  Homo Sapiens

<400>  27

Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp 
1               5                   10                  15      


His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn 
            20                  25                  30          


Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr 
        35                  40                  45              


Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Val Thr Asn Arg Asp 
    50                  55                  60                  


Asn Ala Gln Arg Gln Asp Ile Val Phe Ser Tyr Gln Arg Arg Thr Lys 
65                  70                  75                  80  


Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu 
                85                  90                  95      


Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser 
            100                 105                 110         


Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu 
        115                 120                 125             


Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn 
    130                 135                 140                 


Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile 
145                 150                 155                 160 


Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys 
                165                 170                 175     


Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp 
            180                 185                 190         


Gln Asp Ala Gln Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr 
        195                 200                 205             


Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His 
    210                 215                 220                 


Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met 
225                 230                 235                 240 


Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe 
                245                 250                 255     


Leu Asn Leu Val Gln Arg Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp 
            260                 265                 270         


Gln Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu 
        275                 280                 285             


Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg 
    290                 295                 300                 


Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln 
305                 310                 315                 320 


Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly 
                325                 330                 335     


Gly Asp Asp 
            


<210>  28
<211>  724
<212>  PRT
<213>  Homo Sapiens

<400>  28

Met Pro Glu Glu Val His His Gly Glu Glu Glu Val Glu Thr Phe Ala 
1               5                   10                  15      


Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu Ile Ile Asn Thr Phe 
            20                  25                  30          


Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser 
        35                  40                  45              


Asp Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu Thr Asp Pro Ser Lys 
    50                  55                  60                  


Leu Asp Ser Gly Lys Glu Leu Lys Ile Asp Ile Ile Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Arg Thr Leu Thr Leu Val Asp Thr Gly Ile Gly Met Thr Lys Ala 
                85                  90                  95      


Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Lys Ala 
            100                 105                 110         


Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile Ser Met Ile Gly Gln 
        115                 120                 125             


Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val Ala Glu Lys Val Val 
    130                 135                 140                 


Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr Ala Trp Glu Ser Ser 
145                 150                 155                 160 


Ala Gly Gly Ser Phe Thr Val Arg Ala Asp His Gly Glu Pro Ile Gly 
                165                 170                 175     


Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu Asp Gln Thr Glu Tyr 
            180                 185                 190         


Leu Glu Glu Arg Arg Val Lys Glu Val Val Lys Lys His Ser Gln Phe 
        195                 200                 205             


Ile Gly Tyr Pro Ile Thr Leu Tyr Leu Glu Lys Glu Arg Glu Lys Glu 
    210                 215                 220                 


Ile Ser Asp Asp Glu Ala Glu Glu Glu Lys Gly Glu Lys Glu Glu Glu 
225                 230                 235                 240 


Asp Lys Asp Asp Glu Glu Lys Pro Lys Ile Glu Asp Val Gly Ser Asp 
                245                 250                 255     


Glu Glu Asp Asp Ser Gly Lys Asp Lys Lys Lys Lys Thr Lys Lys Ile 
            260                 265                 270         


Lys Glu Lys Tyr Ile Asp Gln Glu Glu Leu Asn Lys Thr Lys Pro Ile 
        275                 280                 285             


Trp Thr Arg Asn Pro Asp Asp Ile Thr Gln Glu Glu Tyr Gly Glu Phe 
    290                 295                 300                 


Tyr Lys Ser Leu Thr Asn Asp Trp Glu Asp His Leu Ala Val Lys His 
305                 310                 315                 320 


Phe Ser Val Glu Gly Gln Leu Glu Phe Arg Ala Leu Leu Phe Ile Pro 
                325                 330                 335     


Arg Arg Ala Pro Phe Asp Leu Phe Glu Asn Lys Lys Lys Lys Asn Asn 
            340                 345                 350         


Ile Lys Leu Tyr Val Arg Arg Val Phe Ile Met Asp Ser Cys Asp Glu 
        355                 360                 365             


Leu Ile Pro Glu Tyr Leu Asn Phe Ile Arg Gly Val Val Asp Ser Glu 
    370                 375                 380                 


Asp Leu Pro Leu Asn Ile Ser Arg Glu Met Leu Gln Gln Ser Lys Ile 
385                 390                 395                 400 


Leu Lys Val Ile Arg Lys Asn Ile Val Lys Lys Cys Leu Glu Leu Phe 
                405                 410                 415     


Ser Glu Leu Ala Glu Asp Lys Glu Asn Tyr Lys Lys Phe Tyr Glu Ala 
            420                 425                 430         


Phe Ser Lys Asn Leu Lys Leu Gly Ile His Glu Asp Ser Thr Asn Arg 
        435                 440                 445             


Arg Arg Leu Ser Glu Leu Leu Arg Tyr His Thr Ser Gln Ser Gly Asp 
    450                 455                 460                 


Glu Met Thr Ser Leu Ser Glu Tyr Val Ser Arg Met Lys Glu Thr Gln 
465                 470                 475                 480 


Lys Ser Ile Tyr Tyr Ile Thr Gly Glu Ser Lys Glu Gln Val Ala Asn 
                485                 490                 495     


Ser Ala Phe Val Glu Arg Val Arg Lys Arg Gly Phe Glu Val Val Tyr 
            500                 505                 510         


Met Thr Glu Pro Ile Asp Glu Tyr Cys Val Gln Gln Leu Lys Glu Phe 
        515                 520                 525             


Asp Gly Lys Ser Leu Val Ser Val Thr Lys Glu Gly Leu Glu Leu Pro 
    530                 535                 540                 


Glu Asp Glu Glu Glu Lys Lys Lys Met Glu Glu Ser Lys Ala Lys Phe 
545                 550                 555                 560 


Glu Asn Leu Cys Lys Leu Met Lys Glu Ile Leu Asp Lys Lys Val Glu 
                565                 570                 575     


Lys Val Thr Ile Ser Asn Arg Leu Val Ser Ser Pro Cys Cys Ile Val 
            580                 585                 590         


Thr Ser Thr Tyr Gly Trp Thr Ala Asn Met Glu Arg Ile Met Lys Ala 
        595                 600                 605             


Gln Ala Leu Arg Asp Asn Ser Thr Met Gly Tyr Met Met Ala Lys Lys 
    610                 615                 620                 


His Leu Glu Ile Asn Pro Asp His Pro Ile Val Glu Thr Leu Arg Gln 
625                 630                 635                 640 


Lys Ala Glu Ala Asp Lys Asn Asp Lys Ala Val Lys Asp Leu Val Val 
                645                 650                 655     


Leu Leu Phe Glu Thr Ala Leu Leu Ser Ser Gly Phe Ser Leu Glu Asp 
            660                 665                 670         


Pro Gln Thr His Ser Asn Arg Ile Tyr Arg Met Ile Lys Leu Gly Leu 
        675                 680                 685             


Gly Ile Asp Glu Asp Glu Val Ala Ala Glu Glu Pro Asn Ala Ala Val 
    690                 695                 700                 


Pro Asp Glu Ile Pro Pro Leu Glu Gly Asp Glu Asp Ala Ser Arg Met 
705                 710                 715                 720 


Glu Glu Val Asp 
                


<210>  29
<211>  718
<212>  PRT
<213>  Homo Sapiens

<400>  29

Met Ile Val Asp Lys Leu Leu Asp Asp Ser Arg Gly Gly Glu Gly Leu 
1               5                   10                  15      


Arg Asp Ala Ala Gly Gly Cys Gly Leu Met Thr Ser Pro Leu Asn Leu 
            20                  25                  30          


Ser Tyr Phe Tyr Gly Ala Ser Pro Pro Ala Ala Ala Pro Gly Ala Cys 
        35                  40                  45              


Asp Ala Ser Cys Ser Val Leu Gly Pro Ser Ala Pro Gly Ser Pro Gly 
    50                  55                  60                  


Ser Asp Ser Ser Asp Phe Ser Ser Ala Ser Ser Val Ser Ser Cys Gly 
65                  70                  75                  80  


Ala Val Glu Ser Arg Ser Arg Gly Gly Ala Arg Ala Glu Arg Gln Pro 
                85                  90                  95      


Val Glu Pro His Met Gly Val Gly Arg Gln Gln Arg Gly Pro Phe Gln 
            100                 105                 110         


Gly Val Arg Val Lys Asn Ser Val Lys Glu Leu Leu Leu His Ile Arg 
        115                 120                 125             


Ser His Lys Gln Lys Ala Ser Gly Gln Ala Val Asp Asp Phe Lys Thr 
    130                 135                 140                 


Gln Gly Val Asn Ile Glu Gln Phe Arg Glu Leu Lys Asn Thr Val Ser 
145                 150                 155                 160 


Tyr Ser Gly Lys Arg Lys Gly Pro Asp Ser Leu Ser Asp Gly Pro Ala 
                165                 170                 175     


Cys Lys Arg Pro Ala Leu Leu His Ser Gln Phe Leu Thr Pro Pro Gln 
            180                 185                 190         


Thr Pro Thr Pro Gly Glu Ser Met Glu Asp Val His Leu Asn Glu Pro 
        195                 200                 205             


Lys Gln Glu Ser Ser Ala Asp Leu Leu Gln Asn Ile Ile Asn Ile Lys 
    210                 215                 220                 


Asn Glu Cys Ser Pro Val Ser Leu Asn Thr Val Gln Val Ser Trp Leu 
225                 230                 235                 240 


Asn Pro Val Val Val Pro Gln Ser Ser Pro Ala Glu Gln Cys Gln Asp 
                245                 250                 255     


Phe His Gly Gly Gln Val Phe Ser Pro Pro Gln Lys Cys Gln Pro Phe 
            260                 265                 270         


Gln Val Arg Gly Ser Gln Gln Met Ile Asp Gln Ala Ser Leu Tyr Gln 
        275                 280                 285             


Tyr Ser Pro Gln Asn Gln His Val Glu Gln Gln Pro His Tyr Thr His 
    290                 295                 300                 


Lys Pro Thr Leu Glu Tyr Ser Pro Phe Pro Ile Pro Pro Gln Ser Pro 
305                 310                 315                 320 


Ala Tyr Glu Pro Asn Leu Phe Asp Gly Pro Glu Ser Gln Phe Cys Pro 
                325                 330                 335     


Asn Gln Ser Leu Val Ser Leu Leu Gly Asp Gln Arg Glu Ser Glu Asn 
            340                 345                 350         


Ile Ala Asn Pro Met Gln Thr Ser Ser Ser Val Gln Gln Gln Asn Asp 
        355                 360                 365             


Ala His Leu His Ser Phe Ser Met Met Pro Ser Ser Ala Cys Glu Ala 
    370                 375                 380                 


Met Val Gly His Glu Met Ala Ser Asp Ser Ser Asn Thr Ser Leu Pro 
385                 390                 395                 400 


Phe Ser Asn Met Gly Asn Pro Met Asn Thr Thr Gln Leu Gly Lys Ser 
                405                 410                 415     


Leu Phe Gln Trp Gln Val Glu Gln Glu Glu Ser Lys Leu Ala Asn Ile 
            420                 425                 430         


Ser Gln Asp Gln Phe Leu Ser Lys Asp Ala Asp Gly Asp Thr Phe Leu 
        435                 440                 445             


His Ile Ala Val Ala Gln Gly Arg Arg Ala Leu Ser Tyr Val Leu Ala 
    450                 455                 460                 


Arg Lys Met Asn Ala Leu His Met Leu Asp Ile Lys Glu His Asn Gly 
465                 470                 475                 480 


Gln Ser Ala Phe Gln Val Ala Val Ala Ala Asn Gln His Leu Ile Val 
                485                 490                 495     


Gln Asp Leu Val Asn Ile Gly Ala Gln Val Asn Thr Thr Asp Cys Trp 
            500                 505                 510         


Gly Arg Thr Pro Leu His Val Cys Ala Glu Lys Gly His Ser Gln Val 
        515                 520                 525             


Leu Gln Ala Ile Gln Lys Gly Ala Val Gly Ser Asn Gln Phe Val Asp 
    530                 535                 540                 


Leu Glu Ala Thr Asn Tyr Asp Gly Leu Thr Pro Leu His Cys Ala Val 
545                 550                 555                 560 


Ile Ala His Asn Ala Val Val His Glu Leu Gln Arg Asn Gln Gln Pro 
                565                 570                 575     


His Ser Pro Glu Val Gln Glu Leu Leu Leu Lys Asn Lys Ser Leu Val 
            580                 585                 590         


Asp Thr Ile Lys Cys Leu Ile Gln Met Gly Ala Ala Val Glu Ala Lys 
        595                 600                 605             


Asp Arg Lys Ser Gly Arg Thr Ala Leu His Leu Ala Ala Glu Glu Ala 
    610                 615                 620                 


Asn Leu Glu Leu Ile Arg Leu Phe Leu Glu Leu Pro Ser Cys Leu Ser 
625                 630                 635                 640 


Phe Val Asn Ala Lys Ala Tyr Asn Gly Asn Thr Ala Leu His Val Ala 
                645                 650                 655     


Ala Ser Leu Gln Tyr Arg Leu Thr Gln Leu Asp Ala Val Arg Leu Leu 
            660                 665                 670         


Met Arg Lys Gly Ala Asp Pro Ser Thr Arg Asn Leu Glu Asn Glu Gln 
        675                 680                 685             


Pro Val His Leu Val Pro Asp Gly Pro Val Gly Glu Gln Ile Arg Arg 
    690                 695                 700                 


Ile Leu Lys Gly Lys Ser Ile Gln Gln Arg Ala Pro Pro Tyr 
705                 710                 715             


<210>  30
<211>  326
<212>  PRT
<213>  Homo Sapiens

<400>  30

Met Glu Lys Asp Gly Leu Cys Arg Ala Asp Gln Gln Tyr Glu Cys Val 
1               5                   10                  15      


Ala Glu Ile Gly Glu Gly Ala Tyr Gly Lys Val Phe Lys Ala Arg Asp 
            20                  25                  30          


Leu Lys Asn Gly Gly Arg Phe Val Ala Leu Lys Arg Val Arg Val Gln 
        35                  40                  45              


Thr Gly Glu Glu Gly Met Pro Leu Ser Thr Ile Arg Glu Val Ala Val 
    50                  55                  60                  


Leu Arg His Leu Glu Thr Phe Glu His Pro Asn Val Val Arg Leu Phe 
65                  70                  75                  80  


Asp Val Cys Thr Val Ser Arg Thr Asp Arg Glu Thr Lys Leu Thr Leu 
                85                  90                  95      


Val Phe Glu His Val Asp Gln Asp Leu Thr Thr Tyr Leu Asp Lys Val 
            100                 105                 110         


Pro Glu Pro Gly Val Pro Thr Glu Thr Ile Lys Asp Met Met Phe Gln 
        115                 120                 125             


Leu Leu Arg Gly Leu Asp Phe Leu His Ser His Arg Val Val His Arg 
    130                 135                 140                 


Asp Leu Lys Pro Gln Asn Ile Leu Val Thr Ser Ser Gly Gln Ile Lys 
145                 150                 155                 160 


Leu Ala Asp Phe Gly Leu Ala Arg Ile Tyr Ser Phe Gln Met Ala Leu 
                165                 170                 175     


Thr Ser Val Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu 
            180                 185                 190         


Gln Ser Ser Tyr Ala Thr Pro Val Asp Leu Trp Ser Val Gly Cys Ile 
        195                 200                 205             


Phe Ala Glu Met Phe Arg Arg Lys Pro Leu Phe Arg Gly Ser Ser Asp 
    210                 215                 220                 


Val Asp Gln Leu Gly Lys Ile Leu Asp Val Ile Gly Leu Pro Gly Glu 
225                 230                 235                 240 


Glu Asp Trp Pro Arg Asp Val Ala Leu Pro Arg Gln Ala Phe His Ser 
                245                 250                 255     


Lys Ser Ala Gln Pro Ile Glu Lys Phe Val Thr Asp Ile Asp Glu Leu 
            260                 265                 270         


Gly Lys Asp Leu Leu Leu Lys Cys Leu Thr Phe Asn Pro Ala Lys Arg 
        275                 280                 285             


Ile Ser Ala Tyr Ser Ala Leu Ser His Pro Tyr Phe Gln Asp Leu Glu 
    290                 295                 300                 


Arg Cys Lys Glu Asn Leu Asp Ser His Leu Pro Pro Ser Gln Asn Thr 
305                 310                 315                 320 


Ser Glu Leu Asn Thr Ala 
                325     


<210>  31
<211>  142
<212>  PRT
<213>  Homo Sapiens

<400>  31

Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Glu Glu His Lys Lys His 
65                  70                  75                  80  


Ser Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu 
                85                  90                  95      


Thr Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn Lys 
            100                 105                 110         


Ile Ala Lys Glu Thr Asn Asn Lys Lys Lys Glu Phe Glu Glu Thr Ala 
        115                 120                 125             


Lys Lys Val Arg Arg Ala Ile Glu Gln Leu Ala Ala Met Asp 
    130                 135                 140         


<210>  32
<211>  641
<212>  PRT
<213>  Homo Sapiens

<400>  32

Met Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp 
65                  70                  75                  80  


Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn 
                85                  90                  95      


Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His 
225                 230                 235                 240 


Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg 
                405                 410                 415     


Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly 
545                 550                 555                 560 


Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu 
                565                 570                 575     


Val Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe 
            580                 585                 590         


Glu His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser 
        595                 600                 605             


Gly Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala 
    610                 615                 620                 


Gln Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val 
625                 630                 635                 640 


Asp 
    


<210>  33
<211>  732
<212>  PRT
<213>  Homo Sapiens

<400>  33

Met Pro Glu Glu Thr Gln Thr Gln Asp Gln Pro Met Glu Glu Glu Glu 
1               5                   10                  15      


Val Glu Thr Phe Ala Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu 
            20                  25                  30          


Ile Ile Asn Thr Phe Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu 
        35                  40                  45              


Ile Ser Asn Ser Ser Asp Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu 
    50                  55                  60                  


Thr Asp Pro Ser Lys Leu Asp Ser Gly Lys Glu Leu His Ile Asn Leu 
65                  70                  75                  80  


Ile Pro Asn Lys Gln Asp Arg Thr Leu Thr Ile Val Asp Thr Gly Ile 
                85                  90                  95      


Gly Met Thr Lys Ala Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys 
            100                 105                 110         


Ser Gly Thr Lys Ala Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile 
        115                 120                 125             


Ser Met Ile Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val 
    130                 135                 140                 


Ala Glu Lys Val Thr Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr 
145                 150                 155                 160 


Ala Trp Glu Ser Ser Ala Gly Gly Ser Phe Thr Val Arg Thr Asp Thr 
                165                 170                 175     


Gly Glu Pro Met Gly Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu 
            180                 185                 190         


Asp Gln Thr Glu Tyr Leu Glu Glu Arg Arg Ile Lys Glu Ile Val Lys 
        195                 200                 205             


Lys His Ser Gln Phe Ile Gly Tyr Pro Ile Thr Leu Phe Val Glu Lys 
    210                 215                 220                 


Glu Arg Asp Lys Glu Val Ser Asp Asp Glu Ala Glu Glu Lys Glu Asp 
225                 230                 235                 240 


Lys Glu Glu Glu Lys Glu Lys Glu Glu Lys Glu Ser Glu Asp Lys Pro 
                245                 250                 255     


Glu Ile Glu Asp Val Gly Ser Asp Glu Glu Glu Glu Lys Lys Asp Gly 
            260                 265                 270         


Asp Lys Lys Lys Lys Lys Lys Ile Lys Glu Lys Tyr Ile Asp Gln Glu 
        275                 280                 285             


Glu Leu Asn Lys Thr Lys Pro Ile Trp Thr Arg Asn Pro Asp Asp Ile 
    290                 295                 300                 


Thr Asn Glu Glu Tyr Gly Glu Phe Tyr Lys Ser Leu Thr Asn Asp Trp 
305                 310                 315                 320 


Glu Asp His Leu Ala Val Lys His Phe Ser Val Glu Gly Gln Leu Glu 
                325                 330                 335     


Phe Arg Ala Leu Leu Phe Val Pro Arg Arg Ala Pro Phe Asp Leu Phe 
            340                 345                 350         


Glu Asn Arg Lys Lys Lys Asn Asn Ile Lys Leu Tyr Val Arg Arg Val 
        355                 360                 365             


Phe Ile Met Asp Asn Cys Glu Glu Leu Ile Pro Glu Tyr Leu Asn Phe 
    370                 375                 380                 


Ile Arg Gly Val Val Asp Ser Glu Asp Leu Pro Leu Asn Ile Ser Arg 
385                 390                 395                 400 


Glu Met Leu Gln Gln Ser Lys Ile Leu Lys Val Ile Arg Lys Asn Leu 
                405                 410                 415     


Val Lys Lys Cys Leu Glu Leu Phe Thr Glu Leu Ala Glu Asp Lys Glu 
            420                 425                 430         


Asn Tyr Lys Lys Phe Tyr Glu Gln Phe Ser Lys Asn Ile Lys Leu Gly 
        435                 440                 445             


Ile His Glu Asp Ser Gln Asn Arg Lys Lys Leu Ser Glu Leu Leu Arg 
    450                 455                 460                 


Tyr Tyr Thr Ser Ala Ser Gly Asp Glu Met Val Ser Leu Lys Asp Tyr 
465                 470                 475                 480 


Cys Thr Arg Met Lys Glu Asn Gln Lys His Ile Tyr Tyr Ile Thr Gly 
                485                 490                 495     


Glu Thr Lys Asp Gln Val Ala Asn Ser Ala Phe Val Glu Arg Leu Arg 
            500                 505                 510         


Lys His Gly Leu Glu Val Ile Tyr Met Ile Glu Pro Ile Asp Glu Tyr 
        515                 520                 525             


Cys Val Gln Gln Leu Lys Glu Phe Glu Gly Lys Thr Leu Val Ser Val 
    530                 535                 540                 


Thr Lys Glu Gly Leu Glu Leu Pro Glu Asp Glu Glu Glu Lys Lys Lys 
545                 550                 555                 560 


Gln Glu Glu Lys Lys Thr Lys Phe Glu Asn Leu Cys Lys Ile Met Lys 
                565                 570                 575     


Asp Ile Leu Glu Lys Lys Val Glu Lys Val Val Val Ser Asn Arg Leu 
            580                 585                 590         


Val Thr Ser Pro Cys Cys Ile Val Thr Ser Thr Tyr Gly Trp Thr Ala 
        595                 600                 605             


Asn Met Glu Arg Ile Met Lys Ala Gln Ala Leu Arg Asp Asn Ser Thr 
    610                 615                 620                 


Met Gly Tyr Met Ala Ala Lys Lys His Leu Glu Ile Asn Pro Asp His 
625                 630                 635                 640 


Ser Ile Ile Glu Thr Leu Arg Gln Lys Ala Glu Ala Asp Lys Asn Asp 
                645                 650                 655     


Lys Ser Val Lys Asp Leu Val Ile Leu Leu Tyr Glu Thr Ala Leu Leu 
            660                 665                 670         


Ser Ser Gly Phe Ser Leu Glu Asp Pro Gln Thr His Ala Asn Arg Ile 
        675                 680                 685             


Tyr Arg Met Ile Lys Leu Gly Leu Gly Ile Asp Glu Asp Asp Pro Thr 
    690                 695                 700                 


Ala Asp Asp Thr Ser Ala Ala Val Thr Glu Glu Met Pro Pro Leu Glu 
705                 710                 715                 720 


Gly Asp Asp Asp Thr Ser Arg Met Glu Glu Val Asp 
                725                 730         


<210>  34
<211>  442
<212>  PRT
<213>  Homo Sapiens

<400>  34

Met Ala Ser Val Val Leu Pro Ser Gly Ser Gln Cys Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala Pro Pro Gly Leu Arg Leu Arg Leu Leu Leu Leu Leu 
            20                  25                  30          


Phe Ser Ala Ala Ala Leu Ile Pro Thr Gly Asp Gly Gln Asn Leu Phe 
        35                  40                  45              


Thr Lys Asp Val Thr Val Ile Glu Gly Glu Val Ala Thr Ile Ser Cys 
    50                  55                  60                  


Gln Val Asn Lys Ser Asp Asp Ser Val Ile Gln Leu Leu Asn Pro Asn 
65                  70                  75                  80  


Arg Gln Thr Ile Tyr Phe Arg Asp Phe Arg Pro Leu Lys Asp Ser Arg 
                85                  90                  95      


Phe Gln Leu Leu Asn Phe Ser Ser Ser Glu Leu Lys Val Ser Leu Thr 
            100                 105                 110         


Asn Val Ser Ile Ser Asp Glu Gly Arg Tyr Phe Cys Gln Leu Tyr Thr 
        115                 120                 125             


Asp Pro Pro Gln Glu Ser Tyr Thr Thr Ile Thr Val Leu Val Pro Pro 
    130                 135                 140                 


Arg Asn Leu Met Ile Asp Ile Gln Lys Asp Thr Ala Val Glu Gly Glu 
145                 150                 155                 160 


Glu Ile Glu Val Asn Cys Thr Ala Met Ala Ser Lys Pro Ala Thr Thr 
                165                 170                 175     


Ile Arg Trp Phe Lys Gly Asn Thr Glu Leu Lys Gly Lys Ser Glu Val 
            180                 185                 190         


Glu Glu Trp Ser Asp Met Tyr Thr Val Thr Ser Gln Leu Met Leu Lys 
        195                 200                 205             


Val His Lys Glu Asp Asp Gly Val Pro Val Ile Cys Gln Val Glu His 
    210                 215                 220                 


Pro Ala Val Thr Gly Asn Leu Gln Thr Gln Arg Tyr Leu Glu Val Gln 
225                 230                 235                 240 


Tyr Lys Pro Gln Val His Ile Gln Met Thr Tyr Pro Leu Gln Gly Leu 
                245                 250                 255     


Thr Arg Glu Gly Asp Ala Leu Glu Leu Thr Cys Glu Ala Ile Gly Lys 
            260                 265                 270         


Pro Gln Pro Val Met Val Thr Trp Val Arg Val Asp Asp Glu Met Pro 
        275                 280                 285             


Gln His Ala Val Leu Ser Gly Pro Asn Leu Phe Ile Asn Asn Leu Asn 
    290                 295                 300                 


Lys Thr Asp Asn Gly Thr Tyr Arg Cys Glu Ala Ser Asn Ile Val Gly 
305                 310                 315                 320 


Lys Ala His Ser Asp Tyr Met Leu Tyr Val Tyr Asp Pro Pro Thr Thr 
                325                 330                 335     


Ile Pro Pro Pro Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr 
            340                 345                 350         


Thr Ile Leu Thr Ile Ile Thr Asp Ser Arg Ala Gly Glu Glu Gly Ser 
        355                 360                 365             


Ile Arg Ala Val Asp His Ala Val Ile Gly Gly Val Val Ala Val Val 
    370                 375                 380                 


Val Phe Ala Met Leu Cys Leu Leu Ile Ile Leu Gly Arg Tyr Phe Ala 
385                 390                 395                 400 


Arg His Lys Gly Thr Tyr Phe Thr His Glu Ala Lys Gly Ala Asp Asp 
                405                 410                 415     


Ala Ala Asp Ala Asp Thr Ala Ile Ile Asn Ala Glu Gly Gly Gln Asn 
            420                 425                 430         


Asn Ser Glu Glu Lys Lys Glu Tyr Phe Ile 
        435                 440         


<210>  35
<211>  329
<212>  PRT
<213>  Homo Sapiens

<400>  35

Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val Met 
1               5                   10                  15      


Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe 
            20                  25                  30          


Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln 
        35                  40                  45              


Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val 
    50                  55                  60                  


Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser 
65                  70                  75                  80  


Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg 
                85                  90                  95      


Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile 
            100                 105                 110         


His His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser 
        115                 120                 125             


Glu Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile 
    130                 135                 140                 


Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile 
145                 150                 155                 160 


His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys 
                165                 170                 175     


Asn Ser Thr Ile Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn 
            180                 185                 190         


Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro 
        195                 200                 205             


Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys 
    210                 215                 220                 


Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln 
225                 230                 235                 240 


Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val 
                245                 250                 255     


Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys 
            260                 265                 270         


Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu 
        275                 280                 285             


Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro 
    290                 295                 300                 


Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser 
305                 310                 315                 320 


Ser Cys Asp Lys Ser Asp Thr Cys Phe 
                325                 


<210>  36
<211>  445
<212>  PRT
<213>  Homo Sapiens

<400>  36

Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Thr Gly Ser Tyr His Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Asn 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Ala Gly Asn Lys Tyr Val Pro Arg Ala Ile 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Ser Glu Ser Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Met Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Ser Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Met Phe Asp Ser Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Ile Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Asn Val Gln Asn Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ala Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Asp Glu 
            420                 425                 430         


Gln Gly Glu Phe Glu Glu Glu Glu Gly Glu Asp Glu Ala 
        435                 440                 445 


<210>  37
<211>  451
<212>  PRT
<213>  Homo Sapiens

<400>  37

Met Pro Arg Glu Ile Ile Thr Leu Gln Leu Gly Gln Cys Gly Asn Gln 
1               5                   10                  15      


Ile Gly Phe Glu Phe Trp Lys Gln Leu Cys Ala Glu His Gly Ile Ser 
            20                  25                  30          


Pro Glu Gly Ile Val Glu Glu Phe Ala Thr Glu Gly Thr Asp Arg Lys 
        35                  40                  45              


Asp Val Phe Phe Tyr Gln Ala Asp Asp Glu His Tyr Ile Pro Arg Ala 
    50                  55                  60                  


Val Leu Leu Asp Leu Glu Pro Arg Val Ile His Ser Ile Leu Asn Ser 
65                  70                  75                  80  


Pro Tyr Ala Lys Leu Tyr Asn Pro Glu Asn Ile Tyr Leu Ser Glu His 
                85                  90                  95      


Gly Gly Gly Ala Gly Asn Asn Trp Ala Ser Gly Phe Ser Gln Gly Glu 
            100                 105                 110         


Lys Ile His Glu Asp Ile Phe Asp Ile Ile Asp Arg Glu Ala Asp Gly 
        115                 120                 125             


Ser Asp Ser Leu Glu Gly Phe Val Leu Cys His Ser Ile Ala Gly Gly 
    130                 135                 140                 


Thr Gly Ser Gly Leu Gly Ser Tyr Leu Leu Glu Arg Leu Asn Asp Arg 
145                 150                 155                 160 


Tyr Pro Lys Lys Leu Val Gln Thr Tyr Ser Val Phe Pro Asn Gln Asp 
                165                 170                 175     


Glu Met Ser Asp Val Val Val Gln Pro Tyr Asn Ser Leu Leu Thr Leu 
            180                 185                 190         


Lys Arg Leu Thr Gln Asn Ala Asp Cys Val Val Val Leu Asp Asn Thr 
        195                 200                 205             


Ala Leu Asn Arg Ile Ala Thr Asp Arg Leu His Ile Gln Asn Pro Ser 
    210                 215                 220                 


Phe Ser Gln Ile Asn Gln Leu Val Ser Thr Ile Met Ser Ala Ser Thr 
225                 230                 235                 240 


Thr Thr Leu Arg Tyr Pro Gly Tyr Met Asn Asn Asp Leu Ile Gly Leu 
                245                 250                 255     


Ile Ala Ser Leu Ile Pro Thr Pro Arg Leu His Phe Leu Met Thr Gly 
            260                 265                 270         


Tyr Thr Pro Leu Thr Thr Asp Gln Ser Val Ala Ser Val Arg Lys Thr 
        275                 280                 285             


Thr Val Leu Asp Val Met Arg Arg Leu Leu Gln Pro Lys Asn Val Met 
    290                 295                 300                 


Val Ser Thr Gly Arg Asp Arg Gln Thr Asn His Cys Tyr Ile Ala Ile 
305                 310                 315                 320 


Leu Asn Ile Ile Gln Gly Glu Val Asp Pro Thr Gln Val His Lys Ser 
                325                 330                 335     


Leu Gln Arg Ile Arg Glu Arg Lys Leu Ala Asn Phe Ile Pro Trp Gly 
            340                 345                 350         


Pro Ala Ser Ile Gln Val Ala Leu Ser Arg Lys Ser Pro Tyr Leu Pro 
        355                 360                 365             


Ser Ala His Arg Val Ser Gly Leu Met Met Ala Asn His Thr Ser Ile 
    370                 375                 380                 


Ser Ser Leu Phe Glu Arg Thr Cys Arg Gln Tyr Asp Lys Leu Arg Lys 
385                 390                 395                 400 


Arg Glu Ala Phe Leu Glu Gln Phe Arg Lys Glu Asp Met Phe Lys Asp 
                405                 410                 415     


Asn Phe Asp Glu Met Asp Thr Ser Arg Glu Ile Val Gln Gln Leu Ile 
            420                 425                 430         


Asp Glu Tyr His Ala Ala Thr Arg Pro Asp Tyr Ile Ser Trp Gly Thr 
        435                 440                 445             


Gln Glu Gln 
    450     


<210>  38
<211>  2555
<212>  PRT
<213>  Homo Sapiens

<400>  38

Met Pro Pro Leu Leu Ala Pro Leu Leu Cys Leu Ala Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Ala Arg Gly Pro Arg Cys Ser Gln Pro Gly Glu Thr Cys Leu 
            20                  25                  30          


Asn Gly Gly Lys Cys Glu Ala Ala Asn Gly Thr Glu Ala Cys Val Cys 
        35                  40                  45              


Gly Gly Ala Phe Val Gly Pro Arg Cys Gln Asp Pro Asn Pro Cys Leu 
    50                  55                  60                  


Ser Thr Pro Cys Lys Asn Ala Gly Thr Cys His Val Val Asp Arg Arg 
65                  70                  75                  80  


Gly Val Ala Asp Tyr Ala Cys Ser Cys Ala Leu Gly Phe Ser Gly Pro 
                85                  90                  95      


Leu Cys Leu Thr Pro Leu Asp Asn Ala Cys Leu Thr Asn Pro Cys Arg 
            100                 105                 110         


Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr Lys Cys Arg 
        115                 120                 125             


Cys Pro Pro Gly Trp Ser Gly Lys Ser Cys Gln Gln Ala Asp Pro Cys 
    130                 135                 140                 


Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro Phe Glu Ala 
145                 150                 155                 160 


Ser Tyr Ile Cys His Cys Pro Pro Ser Phe His Gly Pro Thr Cys Arg 
                165                 170                 175     


Gln Asp Val Asn Glu Cys Gly Gln Lys Pro Gly Leu Cys Arg His Gly 
            180                 185                 190         


Gly Thr Cys His Asn Glu Val Gly Ser Tyr Arg Cys Val Cys Arg Ala 
        195                 200                 205             


Thr His Thr Gly Pro Asn Cys Glu Arg Pro Tyr Val Pro Cys Ser Pro 
    210                 215                 220                 


Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Val Thr 
225                 230                 235                 240 


His Glu Cys Ala Cys Leu Pro Gly Phe Thr Gly Gln Asn Cys Glu Glu 
                245                 250                 255     


Asn Ile Asp Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys 
            260                 265                 270         


Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Glu Trp Thr 
        275                 280                 285             


Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn 
    290                 295                 300                 


Ala Cys Gln Asn Gly Gly Thr Cys His Asn Thr His Gly Gly Tyr Asn 
305                 310                 315                 320 


Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser Glu Asn Ile 
                325                 330                 335     


Asp Asp Cys Ala Ser Ala Ala Cys Phe His Gly Ala Thr Cys His Asp 
            340                 345                 350         


Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly Arg Thr Gly Leu 
        355                 360                 365             


Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly 
    370                 375                 380                 


Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys 
385                 390                 395                 400 


Pro Ser Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys 
                405                 410                 415     


Ser Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys Ile Asn Thr 
            420                 425                 430         


Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg 
        435                 440                 445             


Cys Glu Ile Asp Val Asn Glu Cys Val Ser Asn Pro Cys Gln Asn Asp 
    450                 455                 460                 


Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile Cys Met Pro 
465                 470                 475                 480 


Gly Tyr Glu Gly Val His Cys Glu Val Asn Thr Asp Glu Cys Ala Ser 
                485                 490                 495     


Ser Pro Cys Leu His Asn Gly Arg Cys Leu Asp Lys Ile Asn Glu Phe 
            500                 505                 510         


Gln Cys Glu Cys Pro Thr Gly Phe Thr Gly His Leu Cys Gln Tyr Asp 
        515                 520                 525             


Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu 
    530                 535                 540                 


Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly 
545                 550                 555                 560 


Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His 
                565                 570                 575     


Tyr Gly Ser Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Arg 
            580                 585                 590         


Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys Ser 
        595                 600                 605             


Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp Arg Asp Asn Ala 
    610                 615                 620                 


Tyr Leu Cys Phe Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile 
625                 630                 635                 640 


Asn Leu Asp Asp Cys Ala Ser Ser Pro Cys Asp Ser Gly Thr Cys Leu 
                645                 650                 655     


Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly 
            660                 665                 670         


Ser Met Cys Asn Ile Asn Ile Asp Glu Cys Ala Gly Asn Pro Cys His 
        675                 680                 685             


Asn Gly Gly Thr Cys Glu Asp Gly Ile Asn Gly Phe Thr Cys Arg Cys 
    690                 695                 700                 


Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys 
705                 710                 715                 720 


Asn Ser Asn Pro Cys Val His Gly Ala Cys Arg Asp Ser Leu Asn Gly 
                725                 730                 735     


Tyr Lys Cys Asp Cys Asp Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile 
            740                 745                 750         


Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys 
        755                 760                 765             


Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg Glu Gly Phe Ser 
    770                 775                 780                 


Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys 
785                 790                 795                 800 


Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn 
                805                 810                 815     


Cys Leu Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro 
            820                 825                 830         


Cys Ala Pro Ser Pro Cys Arg Asn Gly Gly Glu Cys Arg Gln Ser Glu 
        835                 840                 845             


Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly Trp Gln Gly Gln 
    850                 855                 860                 


Thr Cys Glu Val Asp Ile Asn Glu Cys Val Leu Ser Pro Cys Arg His 
865                 870                 875                 880 


Gly Ala Ser Cys Gln Asn Thr His Gly Gly Tyr Arg Cys His Cys Gln 
                885                 890                 895     


Ala Gly Tyr Ser Gly Arg Asn Cys Glu Thr Asp Ile Asp Asp Cys Arg 
            900                 905                 910         


Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Ile Asn Thr 
        915                 920                 925             


Ala Phe Cys Asp Cys Leu Pro Gly Phe Arg Gly Thr Phe Cys Glu Glu 
    930                 935                 940                 


Asp Ile Asn Glu Cys Ala Ser Asp Pro Cys Arg Asn Gly Ala Asn Cys 
945                 950                 955                 960 


Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Ala Gly Phe Ser 
                965                 970                 975     


Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu Ser Ser Cys 
            980                 985                 990         


Phe Asn Gly Gly Thr Cys Val Asp  Gly Ile Asn Ser Phe  Thr Cys Leu 
        995                 1000                 1005             


Cys Pro  Pro Gly Phe Thr Gly  Ser Tyr Cys Gln His  Asp Val Asn 
    1010                 1015                 1020             


Glu Cys  Asp Ser Gln Pro Cys  Leu His Gly Gly Thr  Cys Gln Asp 
    1025                 1030                 1035             


Gly Cys  Gly Ser Tyr Arg Cys  Thr Cys Pro Gln Gly  Tyr Thr Gly 
    1040                 1045                 1050             


Pro Asn  Cys Gln Asn Leu Val  His Trp Cys Asp Ser  Ser Pro Cys 
    1055                 1060                 1065             


Lys Asn  Gly Gly Lys Cys Trp  Gln Thr His Thr Gln  Tyr Arg Cys 
    1070                 1075                 1080             


Glu Cys  Pro Ser Gly Trp Thr  Gly Leu Tyr Cys Asp  Val Pro Ser 
    1085                 1090                 1095             


Val Ser  Cys Glu Val Ala Ala  Gln Arg Gln Gly Val  Asp Val Ala 
    1100                 1105                 1110             


Arg Leu  Cys Gln His Gly Gly  Leu Cys Val Asp Ala  Gly Asn Thr 
    1115                 1120                 1125             


His His  Cys Arg Cys Gln Ala  Gly Tyr Thr Gly Ser  Tyr Cys Glu 
    1130                 1135                 1140             


Asp Leu  Val Asp Glu Cys Ser  Pro Ser Pro Cys Gln  Asn Gly Ala 
    1145                 1150                 1155             


Thr Cys  Thr Asp Tyr Leu Gly  Gly Tyr Ser Cys Lys  Cys Val Ala 
    1160                 1165                 1170             


Gly Tyr  His Gly Val Asn Cys  Ser Glu Glu Ile Asp  Glu Cys Leu 
    1175                 1180                 1185             


Ser His  Pro Cys Gln Asn Gly  Gly Thr Cys Leu Asp  Leu Pro Asn 
    1190                 1195                 1200             


Thr Tyr  Lys Cys Ser Cys Pro  Arg Gly Thr Gln Gly  Val His Cys 
    1205                 1210                 1215             


Glu Ile  Asn Val Asp Asp Cys  Asn Pro Pro Val Asp  Pro Val Ser 
    1220                 1225                 1230             


Arg Ser  Pro Lys Cys Phe Asn  Asn Gly Thr Cys Val  Asp Gln Val 
    1235                 1240                 1245             


Gly Gly  Tyr Ser Cys Thr Cys  Pro Pro Gly Phe Val  Gly Glu Arg 
    1250                 1255                 1260             


Cys Glu  Gly Asp Val Asn Glu  Cys Leu Ser Asn Pro  Cys Asp Ala 
    1265                 1270                 1275             


Arg Gly  Thr Gln Asn Cys Val  Gln Arg Val Asn Asp  Phe His Cys 
    1280                 1285                 1290             


Glu Cys  Arg Ala Gly His Thr  Gly Arg Arg Cys Glu  Ser Val Ile 
    1295                 1300                 1305             


Asn Gly  Cys Lys Gly Lys Pro  Cys Lys Asn Gly Gly  Thr Cys Ala 
    1310                 1315                 1320             


Val Ala  Ser Asn Thr Ala Arg  Gly Phe Ile Cys Lys  Cys Pro Ala 
    1325                 1330                 1335             


Gly Phe  Glu Gly Ala Thr Cys  Glu Asn Asp Ala Arg  Thr Cys Gly 
    1340                 1345                 1350             


Ser Leu  Arg Cys Leu Asn Gly  Gly Thr Cys Ile Ser  Gly Pro Arg 
    1355                 1360                 1365             


Ser Pro  Thr Cys Leu Cys Leu  Gly Pro Phe Thr Gly  Pro Glu Cys 
    1370                 1375                 1380             


Gln Phe  Pro Ala Ser Ser Pro  Cys Leu Gly Gly Asn  Pro Cys Tyr 
    1385                 1390                 1395             


Asn Gln  Gly Thr Cys Glu Pro  Thr Ser Glu Ser Pro  Phe Tyr Arg 
    1400                 1405                 1410             


Cys Leu  Cys Pro Ala Lys Phe  Asn Gly Leu Leu Cys  His Ile Leu 
    1415                 1420                 1425             


Asp Tyr  Ser Phe Gly Gly Gly  Ala Gly Arg Asp Ile  Pro Pro Pro 
    1430                 1435                 1440             


Leu Ile  Glu Glu Ala Cys Glu  Leu Pro Glu Cys Gln  Glu Asp Ala 
    1445                 1450                 1455             


Gly Asn  Lys Val Cys Ser Leu  Gln Cys Asn Asn His  Ala Cys Gly 
    1460                 1465                 1470             


Trp Asp  Gly Gly Asp Cys Ser  Leu Asn Phe Asn Asp  Pro Trp Lys 
    1475                 1480                 1485             


Asn Cys  Thr Gln Ser Leu Gln  Cys Trp Lys Tyr Phe  Ser Asp Gly 
    1490                 1495                 1500             


His Cys  Asp Ser Gln Cys Asn  Ser Ala Gly Cys Leu  Phe Asp Gly 
    1505                 1510                 1515             


Phe Asp  Cys Gln Arg Ala Glu  Gly Gln Cys Asn Pro  Leu Tyr Asp 
    1520                 1525                 1530             


Gln Tyr  Cys Lys Asp His Phe  Ser Asp Gly His Cys  Asp Gln Gly 
    1535                 1540                 1545             


Cys Asn  Ser Ala Glu Cys Glu  Trp Asp Gly Leu Asp  Cys Ala Glu 
    1550                 1555                 1560             


His Val  Pro Glu Arg Leu Ala  Ala Gly Thr Leu Val  Val Val Val 
    1565                 1570                 1575             


Leu Met  Pro Pro Glu Gln Leu  Arg Asn Ser Ser Phe  His Phe Leu 
    1580                 1585                 1590             


Arg Glu  Leu Ser Arg Val Leu  His Thr Asn Val Val  Phe Lys Arg 
    1595                 1600                 1605             


Asp Ala  His Gly Gln Gln Met  Ile Phe Pro Tyr Tyr  Gly Arg Glu 
    1610                 1615                 1620             


Glu Glu  Leu Arg Lys His Pro  Ile Lys Arg Ala Ala  Glu Gly Trp 
    1625                 1630                 1635             


Ala Ala  Pro Asp Ala Leu Leu  Gly Gln Val Lys Ala  Ser Leu Leu 
    1640                 1645                 1650             


Pro Gly  Gly Ser Glu Gly Gly  Arg Arg Arg Arg Glu  Leu Asp Pro 
    1655                 1660                 1665             


Met Asp  Val Arg Gly Ser Ile  Val Tyr Leu Glu Ile  Asp Asn Arg 
    1670                 1675                 1680             


Gln Cys  Val Gln Ala Ser Ser  Gln Cys Phe Gln Ser  Ala Thr Asp 
    1685                 1690                 1695             


Val Ala  Ala Phe Leu Gly Ala  Leu Ala Ser Leu Gly  Ser Leu Asn 
    1700                 1705                 1710             


Ile Pro  Tyr Lys Ile Glu Ala  Val Gln Ser Glu Thr  Val Glu Pro 
    1715                 1720                 1725             


Pro Pro  Pro Ala Gln Leu His  Phe Met Tyr Val Ala  Ala Ala Ala 
    1730                 1735                 1740             


Phe Val  Leu Leu Phe Phe Val  Gly Cys Gly Val Leu  Leu Ser Arg 
    1745                 1750                 1755             


Lys Arg  Arg Arg Gln His Gly  Gln Leu Trp Phe Pro  Glu Gly Phe 
    1760                 1765                 1770             


Lys Val  Ser Glu Ala Ser Lys  Lys Lys Arg Arg Glu  Pro Leu Gly 
    1775                 1780                 1785             


Glu Asp  Ser Val Gly Leu Lys  Pro Leu Lys Asn Ala  Ser Asp Gly 
    1790                 1795                 1800             


Ala Leu  Met Asp Asp Asn Gln  Asn Glu Trp Gly Asp  Glu Asp Leu 
    1805                 1810                 1815             


Glu Thr  Lys Lys Phe Arg Phe  Glu Glu Pro Val Val  Leu Pro Asp 
    1820                 1825                 1830             


Leu Asp  Asp Gln Thr Asp His  Arg Gln Trp Thr Gln  Gln His Leu 
    1835                 1840                 1845             


Asp Ala  Ala Asp Leu Arg Met  Ser Ala Met Ala Pro  Thr Pro Pro 
    1850                 1855                 1860             


Gln Gly  Glu Val Asp Ala Asp  Cys Met Asp Val Asn  Val Arg Gly 
    1865                 1870                 1875             


Pro Asp  Gly Phe Thr Pro Leu  Met Ile Ala Ser Cys  Ser Gly Gly 
    1880                 1885                 1890             


Gly Leu  Glu Thr Gly Asn Ser  Glu Glu Glu Glu Asp  Ala Pro Ala 
    1895                 1900                 1905             


Val Ile  Ser Asp Phe Ile Tyr  Gln Gly Ala Ser Leu  His Asn Gln 
    1910                 1915                 1920             


Thr Asp  Arg Thr Gly Glu Thr  Ala Leu His Leu Ala  Ala Arg Tyr 
    1925                 1930                 1935             


Ser Arg  Ser Asp Ala Ala Lys  Arg Leu Leu Glu Ala  Ser Ala Asp 
    1940                 1945                 1950             


Ala Asn  Ile Gln Asp Asn Met  Gly Arg Thr Pro Leu  His Ala Ala 
    1955                 1960                 1965             


Val Ser  Ala Asp Ala Gln Gly  Val Phe Gln Ile Leu  Ile Arg Asn 
    1970                 1975                 1980             


Arg Ala  Thr Asp Leu Asp Ala  Arg Met His Asp Gly  Thr Thr Pro 
    1985                 1990                 1995             


Leu Ile  Leu Ala Ala Arg Leu  Ala Val Glu Gly Met  Leu Glu Asp 
    2000                 2005                 2010             


Leu Ile  Asn Ser His Ala Asp  Val Asn Ala Val Asp  Asp Leu Gly 
    2015                 2020                 2025             


Lys Ser  Ala Leu His Trp Ala  Ala Ala Val Asn Asn  Val Asp Ala 
    2030                 2035                 2040             


Ala Val  Val Leu Leu Lys Asn  Gly Ala Asn Lys Asp  Met Gln Asn 
    2045                 2050                 2055             


Asn Arg  Glu Glu Thr Pro Leu  Phe Leu Ala Ala Arg  Glu Gly Ser 
    2060                 2065                 2070             


Tyr Glu  Thr Ala Lys Val Leu  Leu Asp His Phe Ala  Asn Arg Asp 
    2075                 2080                 2085             


Ile Thr  Asp His Met Asp Arg  Leu Pro Arg Asp Ile  Ala Gln Glu 
    2090                 2095                 2100             


Arg Met  His His Asp Ile Val  Arg Leu Leu Asp Glu  Tyr Asn Leu 
    2105                 2110                 2115             


Val Arg  Ser Pro Gln Leu His  Gly Ala Pro Leu Gly  Gly Thr Pro 
    2120                 2125                 2130             


Thr Leu  Ser Pro Pro Leu Cys  Ser Pro Asn Gly Tyr  Leu Gly Ser 
    2135                 2140                 2145             


Leu Lys  Pro Gly Val Gln Gly  Lys Lys Val Arg Lys  Pro Ser Ser 
    2150                 2155                 2160             


Lys Gly  Leu Ala Cys Gly Ser  Lys Glu Ala Lys Asp  Leu Lys Ala 
    2165                 2170                 2175             


Arg Arg  Lys Lys Ser Gln Asp  Gly Lys Gly Cys Leu  Leu Asp Ser 
    2180                 2185                 2190             


Ser Gly  Met Leu Ser Pro Val  Asp Ser Leu Glu Ser  Pro His Gly 
    2195                 2200                 2205             


Tyr Leu  Ser Asp Val Ala Ser  Pro Pro Leu Leu Pro  Ser Pro Phe 
    2210                 2215                 2220             


Gln Gln  Ser Pro Ser Val Pro  Leu Asn His Leu Pro  Gly Met Pro 
    2225                 2230                 2235             


Asp Thr  His Leu Gly Ile Gly  His Leu Asn Val Ala  Ala Lys Pro 
    2240                 2245                 2250             


Glu Met  Ala Ala Leu Gly Gly  Gly Gly Arg Leu Ala  Phe Glu Thr 
    2255                 2260                 2265             


Gly Pro  Pro Arg Leu Ser His  Leu Pro Val Ala Ser  Gly Thr Ser 
    2270                 2275                 2280             


Thr Val  Leu Gly Ser Ser Ser  Gly Gly Ala Leu Asn  Phe Thr Val 
    2285                 2290                 2295             


Gly Gly  Ser Thr Ser Leu Asn  Gly Gln Cys Glu Trp  Leu Ser Arg 
    2300                 2305                 2310             


Leu Gln  Ser Gly Met Val Pro  Asn Gln Tyr Asn Pro  Leu Arg Gly 
    2315                 2320                 2325             


Ser Val  Ala Pro Gly Pro Leu  Ser Thr Gln Ala Pro  Ser Leu Gln 
    2330                 2335                 2340             


His Gly  Met Val Gly Pro Leu  His Ser Ser Leu Ala  Ala Ser Ala 
    2345                 2350                 2355             


Leu Ser  Gln Met Met Ser Tyr  Gln Gly Leu Pro Ser  Thr Arg Leu 
    2360                 2365                 2370             


Ala Thr  Gln Pro His Leu Val  Gln Thr Gln Gln Val  Gln Pro Gln 
    2375                 2380                 2385             


Asn Leu  Gln Met Gln Gln Gln  Asn Leu Gln Pro Ala  Asn Ile Gln 
    2390                 2395                 2400             


Gln Gln  Gln Ser Leu Gln Pro  Pro Pro Pro Pro Pro  Gln Pro His 
    2405                 2410                 2415             


Leu Gly  Val Ser Ser Ala Ala  Ser Gly His Leu Gly  Arg Ser Phe 
    2420                 2425                 2430             


Leu Ser  Gly Glu Pro Ser Gln  Ala Asp Val Gln Pro  Leu Gly Pro 
    2435                 2440                 2445             


Ser Ser  Leu Ala Val His Thr  Ile Leu Pro Gln Glu  Ser Pro Ala 
    2450                 2455                 2460             


Leu Pro  Thr Ser Leu Pro Ser  Ser Leu Val Pro Pro  Val Thr Ala 
    2465                 2470                 2475             


Ala Gln  Phe Leu Thr Pro Pro  Ser Gln His Ser Tyr  Ser Ser Pro 
    2480                 2485                 2490             


Val Asp  Asn Thr Pro Ser His  Gln Leu Gln Val Pro  Glu His Pro 
    2495                 2500                 2505             


Phe Leu  Thr Pro Ser Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser 
    2510                 2515                 2520             


Ser Pro  His Ser Asn Val Ser  Asp Trp Ser Glu Gly  Val Ser Ser 
    2525                 2530                 2535             


Pro Pro  Thr Ser Met Gln Ser  Gln Ile Ala Arg Ile  Pro Glu Ala 
    2540                 2545                 2550             


Phe Lys  
    2555 


<210>  39
<211>  189
<212>  PRT
<213>  Homo Sapiens

<400>  39

Met Leu Gly Met Ile Lys Asn Ser Leu Phe Gly Ser Val Glu Thr Trp 
1               5                   10                  15      


Pro Trp Gln Val Leu Ser Lys Gly Asp Lys Glu Glu Val Ala Tyr Glu 
            20                  25                  30          


Glu Arg Ala Cys Glu Gly Gly Lys Phe Ala Thr Val Glu Val Thr Asp 
        35                  40                  45              


Lys Pro Val Asp Glu Ala Leu Arg Glu Ala Met Pro Lys Val Ala Lys 
    50                  55                  60                  


Tyr Ala Gly Gly Thr Asn Asp Lys Gly Ile Gly Met Gly Met Thr Val 
65                  70                  75                  80  


Pro Ile Ser Phe Ala Val Phe Pro Asn Glu Asp Gly Ser Leu Gln Lys 
                85                  90                  95      


Lys Leu Lys Val Trp Phe Arg Ile Pro Asn Gln Phe Gln Ser Asp Pro 
            100                 105                 110         


Pro Ala Pro Ser Asp Lys Ser Val Lys Ile Glu Glu Arg Glu Gly Ile 
        115                 120                 125             


Thr Val Tyr Ser Met Gln Phe Gly Gly Tyr Ala Lys Glu Ala Asp Tyr 
    130                 135                 140                 


Val Ala Gln Ala Thr Arg Leu Arg Ala Ala Leu Glu Gly Thr Ala Thr 
145                 150                 155                 160 


Tyr Arg Gly Asp Ile Tyr Phe Cys Thr Gly Tyr Asp Pro Pro Met Lys 
                165                 170                 175     


Pro Tyr Gly Arg Arg Asn Glu Ile Trp Leu Leu Lys Thr 
            180                 185                 


<210>  40
<211>  272
<212>  PRT
<213>  Homo Sapiens

<400>  40

Met Ala Ala Lys Val Phe Glu Ser Ile Gly Lys Phe Gly Leu Ala Leu 
1               5                   10                  15      


Ala Val Ala Gly Gly Val Val Asn Ser Ala Leu Tyr Asn Val Asp Ala 
            20                  25                  30          


Gly His Arg Ala Val Ile Phe Asp Arg Phe Arg Gly Val Gln Asp Ile 
        35                  40                  45              


Val Val Gly Glu Gly Thr His Phe Leu Ile Pro Trp Val Gln Lys Pro 
    50                  55                  60                  


Ile Ile Phe Asp Cys Arg Ser Arg Pro Arg Asn Val Pro Val Ile Thr 
65                  70                  75                  80  


Gly Ser Lys Asp Leu Gln Asn Val Asn Ile Thr Leu Arg Ile Leu Phe 
                85                  90                  95      


Arg Pro Val Ala Ser Gln Leu Pro Arg Ile Phe Thr Ser Ile Gly Glu 
            100                 105                 110         


Asp Tyr Asp Glu Arg Val Leu Pro Ser Ile Thr Thr Glu Ile Leu Lys 
        115                 120                 125             


Ser Val Val Ala Arg Phe Asp Ala Gly Glu Leu Ile Thr Gln Arg Glu 
    130                 135                 140                 


Leu Val Ser Arg Gln Val Ser Asp Asp Leu Thr Glu Arg Ala Ala Thr 
145                 150                 155                 160 


Phe Gly Leu Ile Leu Asp Asp Val Ser Leu Thr His Leu Thr Phe Gly 
                165                 170                 175     


Lys Glu Phe Thr Glu Ala Val Glu Ala Lys Gln Val Ala Gln Gln Glu 
            180                 185                 190         


Ala Glu Arg Ala Arg Phe Val Val Glu Lys Ala Glu Gln Gln Lys Lys 
        195                 200                 205             


Ala Ala Ile Ile Ser Ala Glu Gly Asp Ser Lys Ala Ala Glu Leu Ile 
    210                 215                 220                 


Ala Asn Ser Leu Ala Thr Ala Gly Asp Gly Leu Ile Glu Leu Arg Lys 
225                 230                 235                 240 


Leu Glu Ala Ala Glu Asp Ile Ala Tyr Gln Leu Ser Arg Ser Arg Asn 
                245                 250                 255     


Ile Thr Tyr Leu Pro Ala Gly Gln Ser Val Leu Leu Gln Leu Pro Gln 
            260                 265                 270         


<210>  41
<211>  254
<212>  PRT
<213>  Homo Sapiens

<400>  41

Met Ala Ser Leu Leu Lys Val Asp Gln Glu Val Lys Leu Lys Val Asp 
1               5                   10                  15      


Ser Phe Arg Glu Arg Ile Thr Ser Glu Ala Glu Asp Leu Val Ala Asn 
            20                  25                  30          


Phe Phe Pro Lys Lys Leu Leu Glu Leu Asp Ser Phe Leu Lys Glu Pro 
        35                  40                  45              


Ile Leu Asn Ile His Asp Leu Thr Gln Ile His Ser Asp Met Asn Leu 
    50                  55                  60                  


Pro Val Pro Asp Pro Ile Leu Leu Thr Asn Ser His Asp Gly Leu Asp 
65                  70                  75                  80  


Gly Pro Thr Tyr Lys Lys Arg Arg Leu Asp Glu Cys Glu Glu Ala Phe 
                85                  90                  95      


Gln Gly Thr Lys Val Phe Val Met Pro Asn Gly Met Leu Lys Ser Asn 
            100                 105                 110         


Gln Gln Leu Val Asp Ile Ile Glu Lys Val Lys Pro Glu Ile Arg Leu 
        115                 120                 125             


Leu Ile Glu Lys Cys Asn Thr Val Lys Met Trp Val Gln Leu Leu Ile 
    130                 135                 140                 


Pro Arg Ile Glu Asp Gly Asn Asn Phe Gly Val Ser Ile Gln Glu Glu 
145                 150                 155                 160 


Thr Val Ala Glu Leu Arg Thr Val Glu Ser Glu Ala Ala Ser Tyr Leu 
                165                 170                 175     


Asp Gln Ile Ser Arg Tyr Tyr Ile Thr Arg Ala Lys Leu Val Ser Lys 
            180                 185                 190         


Ile Ala Lys Tyr Pro His Val Glu Asp Tyr Arg Arg Thr Val Thr Glu 
        195                 200                 205             


Ile Asp Glu Lys Glu Tyr Ile Ser Leu Arg Leu Ile Ile Ser Glu Leu 
    210                 215                 220                 


Arg Asn Gln Tyr Val Thr Leu His Asp Met Ile Leu Lys Asn Ile Glu 
225                 230                 235                 240 


Lys Ile Lys Arg Pro Arg Ser Ser Asn Ala Glu Thr Leu Tyr 
                245                 250                 


<210>  42
<211>  107
<212>  DNA
<213>  Homo Sapiens

<400>  42
gtgctcactt cggcagcaca tatactaaaa ttggaacgat acagagaaga ttagcatggc       60

ccctgcgcaa ggatgacacg caaattcgtg aagcattcca tattttt                    107


<210>  43
<211>  211
<212>  PRT
<213>  Homo Sapiens

<400>  43

Met Ala Pro Ser Arg Asn Gly Met Val Leu Lys Pro His Phe His Lys 
1               5                   10                  15      


Asp Trp Gln Arg Arg Val Ala Thr Trp Phe Asn Gln Pro Ala Arg Lys 
            20                  25                  30          


Ile Arg Arg Arg Lys Ala Arg Gln Ala Lys Ala Arg Arg Ile Ala Pro 
        35                  40                  45              


Arg Pro Ala Ser Gly Pro Ile Arg Pro Ile Val Arg Cys Pro Thr Val 
    50                  55                  60                  


Arg Tyr His Thr Lys Val Arg Ala Gly Arg Gly Phe Ser Leu Glu Glu 
65                  70                  75                  80  


Leu Arg Val Ala Gly Ile His Lys Lys Val Ala Arg Thr Ile Gly Ile 
                85                  90                  95      


Ser Val Asp Pro Arg Arg Arg Asn Lys Ser Thr Glu Ser Leu Gln Ala 
            100                 105                 110         


Asn Val Gln Arg Leu Lys Glu Tyr Arg Ser Lys Leu Ile Leu Phe Pro 
        115                 120                 125             


Arg Lys Pro Ser Ala Pro Lys Lys Gly Asp Ser Ser Ala Glu Glu Leu 
    130                 135                 140                 


Lys Leu Ala Thr Gln Leu Thr Gly Pro Val Met Pro Val Arg Asn Val 
145                 150                 155                 160 


Tyr Lys Lys Glu Lys Ala Arg Val Ile Thr Glu Glu Glu Lys Asn Phe 
                165                 170                 175     


Lys Ala Phe Ala Ser Leu Arg Met Ala Arg Ala Asn Ala Arg Leu Phe 
            180                 185                 190         


Gly Ile Arg Ala Lys Arg Ala Lys Glu Ala Ala Glu Gln Asp Val Glu 
        195                 200                 205             


Lys Lys Lys 
    210     


<210>  44
<211>  227
<212>  PRT
<213>  Homo Sapiens

<400>  44

Met Gly Gly Lys Leu Ser Lys Lys Lys Lys Gly Tyr Asn Val Asn Asp 
1               5                   10                  15      


Glu Lys Ala Lys Glu Lys Asp Lys Lys Ala Glu Gly Ala Ala Thr Glu 
            20                  25                  30          


Glu Glu Gly Thr Pro Lys Glu Ser Glu Pro Gln Ala Ala Ala Glu Pro 
        35                  40                  45              


Ala Glu Ala Lys Glu Gly Lys Glu Lys Pro Asp Gln Asp Ala Glu Gly 
    50                  55                  60                  


Lys Ala Glu Glu Lys Glu Gly Glu Lys Asp Ala Ala Ala Ala Lys Glu 
65                  70                  75                  80  


Glu Ala Pro Lys Ala Glu Pro Glu Lys Thr Glu Gly Ala Ala Glu Ala 
                85                  90                  95      


Lys Ala Glu Pro Pro Lys Ala Pro Glu Gln Glu Gln Ala Ala Pro Gly 
            100                 105                 110         


Pro Ala Ala Gly Gly Glu Ala Pro Lys Ala Ala Glu Ala Ala Ala Ala 
        115                 120                 125             


Pro Ala Glu Ser Ala Ala Pro Ala Ala Gly Glu Glu Pro Ser Lys Glu 
    130                 135                 140                 


Glu Gly Glu Pro Lys Lys Thr Glu Ala Pro Ala Ala Pro Ala Ala Gln 
145                 150                 155                 160 


Glu Thr Lys Ser Asp Gly Ala Pro Ala Ser Asp Ser Lys Pro Gly Ser 
                165                 170                 175     


Ser Glu Ala Ala Pro Ser Ser Lys Glu Thr Pro Ala Ala Thr Glu Ala 
            180                 185                 190         


Pro Ser Ser Thr Pro Lys Ala Gln Gly Pro Ala Ala Ser Ala Glu Glu 
        195                 200                 205             


Pro Lys Pro Val Glu Ala Pro Ala Ala Asn Ser Asp Gln Thr Val Thr 
    210                 215                 220                 


Val Lys Glu 
225         


<210>  45
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  45

Met Asn Tyr Pro Leu Thr Leu Glu Met Asp Leu Glu Asn Leu Glu Asp 
1               5                   10                  15      


Leu Phe Trp Glu Leu Asp Arg Leu Asp Asn Tyr Asn Asp Thr Ser Leu 
            20                  25                  30          


Val Glu Asn His Leu Cys Pro Ala Thr Glu Gly Pro Leu Met Ala Ser 
        35                  40                  45              


Phe Lys Ala Val Phe Val Pro Val Ala Tyr Ser Leu Ile Phe Leu Leu 
    50                  55                  60                  


Gly Val Ile Gly Asn Val Leu Val Leu Val Ile Leu Glu Arg His Arg 
65                  70                  75                  80  


Gln Thr Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu Ala Val Ala 
                85                  90                  95      


Asp Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala Glu Gly Ser 
            100                 105                 110         


Val Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val Ile Ala Leu 
        115                 120                 125             


His Lys Val Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala Cys Ile Ala 
    130                 135                 140                 


Val Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala Tyr Arg His 
145                 150                 155                 160 


Arg Arg Leu Leu Ser Ile His Ile Thr Cys Gly Thr Ile Trp Leu Val 
                165                 170                 175     


Gly Phe Leu Leu Ala Leu Pro Glu Ile Leu Phe Ala Lys Val Ser Gln 
            180                 185                 190         


Gly His His Asn Asn Ser Leu Pro Arg Cys Thr Phe Ser Gln Glu Asn 
        195                 200                 205             


Gln Ala Glu Thr His Ala Trp Phe Thr Ser Arg Phe Leu Tyr His Val 
    210                 215                 220                 


Ala Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys Tyr Val Gly 
225                 230                 235                 240 


Val Val His Arg Leu Arg Gln Ala Gln Arg Arg Pro Gln Arg Gln Lys 
                245                 250                 255     


Ala Val Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe Leu Cys Trp 
            260                 265                 270         


Ser Pro Tyr His Ile Val Ile Phe Leu Asp Thr Leu Ala Arg Leu Lys 
        275                 280                 285             


Ala Val Asp Asn Thr Cys Lys Leu Asn Gly Ser Leu Pro Val Ala Ile 
    290                 295                 300                 


Thr Met Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu Asn Pro Met 
305                 310                 315                 320 


Leu Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu Ser Arg Leu 
                325                 330                 335     


Leu Thr Lys Leu Gly Cys Thr Gly Pro Ala Ser Leu Cys Gln Leu Phe 
            340                 345                 350         


Pro Ser Trp Arg Arg Ser Ser Leu Ser Glu Ser Glu Asn Ala Thr Ser 
        355                 360                 365             


Leu Thr Thr Phe 
    370         


<210>  46
<211>  160
<212>  PRT
<213>  Homo Sapiens

<400>  46

Met Ser Glu Val Arg Pro Leu Ser Arg Asp Ile Leu Met Glu Thr Leu 
1               5                   10                  15      


Leu Tyr Glu Gln Leu Leu Glu Pro Pro Thr Met Glu Val Leu Gly Met 
            20                  25                  30          


Thr Asp Ser Glu Glu Asp Leu Asp Pro Met Glu Asp Phe Asp Ser Leu 
        35                  40                  45              


Glu Cys Met Glu Gly Ser Asp Ala Leu Ala Leu Arg Leu Ala Cys Ile 
    50                  55                  60                  


Gly Asp Glu Met Asp Val Ser Leu Arg Ala Pro Arg Leu Ala Gln Leu 
65                  70                  75                  80  


Ser Glu Val Ala Met His Ser Leu Gly Leu Ala Phe Ile Tyr Asp Gln 
                85                  90                  95      


Thr Glu Asp Ile Arg Asp Val Leu Arg Ser Phe Met Asp Gly Phe Thr 
            100                 105                 110         


Thr Leu Lys Glu Asn Ile Met Arg Phe Trp Arg Ser Pro Asn Pro Gly 
        115                 120                 125             


Ser Trp Val Ser Cys Glu Gln Val Leu Leu Ala Leu Leu Leu Leu Leu 
    130                 135                 140                 


Ala Leu Leu Leu Pro Leu Leu Ser Gly Gly Leu His Leu Leu Leu Lys 
145                 150                 155                 160 


<210>  47
<211>  162
<212>  PRT
<213>  Homo Sapiens

<400>  47

Met Lys Gly Phe Thr Ala Thr Leu Phe Leu Trp Thr Leu Ile Phe Pro 
1               5                   10                  15      


Ser Cys Ser Gly Gly Gly Gly Gly Lys Ala Trp Pro Thr His Val Val 
            20                  25                  30          


Cys Ser Asp Ser Gly Leu Glu Val Leu Tyr Gln Ser Cys Asp Pro Leu 
        35                  40                  45              


Gln Asp Phe Gly Phe Ser Val Glu Lys Cys Ser Lys Gln Leu Lys Ser 
    50                  55                  60                  


Asn Ile Asn Ile Arg Phe Gly Ile Ile Leu Arg Glu Asp Ile Lys Glu 
65                  70                  75                  80  


Leu Phe Leu Asp Leu Ala Leu Met Ser Gln Gly Ser Ser Val Leu Asn 
                85                  90                  95      


Phe Ser Tyr Pro Ile Cys Glu Ala Ala Leu Pro Lys Phe Ser Phe Cys 
            100                 105                 110         


Gly Arg Arg Lys Gly Glu Gln Ile Tyr Tyr Ala Gly Pro Val Asn Asn 
        115                 120                 125             


Pro Glu Phe Thr Ile Pro Gln Gly Glu Tyr Gln Val Leu Leu Glu Leu 
    130                 135                 140                 


Tyr Thr Glu Lys Arg Ser Thr Val Ala Cys Ala Asn Ala Thr Ile Met 
145                 150                 155                 160 


Cys Ser 
        


<210>  48
<211>  811
<212>  PRT
<213>  Homo Sapiens

<400>  48

Met Arg Leu Ile Arg Asn Ile Tyr Ile Phe Cys Ser Ile Val Met Thr 
1               5                   10                  15      


Ala Glu Gly Asp Ala Pro Glu Leu Pro Glu Glu Arg Glu Leu Met Thr 
            20                  25                  30          


Asn Cys Ser Asn Met Ser Leu Arg Lys Val Pro Ala Asp Leu Thr Pro 
        35                  40                  45              


Ala Thr Thr Thr Leu Asp Leu Ser Tyr Asn Leu Leu Phe Gln Leu Gln 
    50                  55                  60                  


Ser Ser Asp Phe His Ser Val Ser Lys Leu Arg Val Leu Ile Leu Cys 
65                  70                  75                  80  


His Asn Arg Ile Gln Gln Leu Asp Leu Lys Thr Phe Glu Phe Asn Lys 
                85                  90                  95      


Glu Leu Arg Tyr Leu Asp Leu Ser Asn Asn Arg Leu Lys Ser Val Thr 
            100                 105                 110         


Trp Tyr Leu Leu Ala Gly Leu Arg Tyr Leu Asp Leu Ser Phe Asn Asp 
        115                 120                 125             


Phe Asp Thr Met Pro Ile Cys Glu Glu Ala Gly Asn Met Ser His Leu 
    130                 135                 140                 


Glu Ile Leu Gly Leu Ser Gly Ala Lys Ile Gln Lys Ser Asp Phe Gln 
145                 150                 155                 160 


Lys Ile Ala His Leu His Leu Asn Thr Val Phe Leu Gly Phe Arg Thr 
                165                 170                 175     


Leu Pro His Tyr Glu Glu Gly Ser Leu Pro Ile Leu Asn Thr Thr Lys 
            180                 185                 190         


Leu His Ile Val Leu Pro Met Asp Thr Asn Phe Trp Val Leu Leu Arg 
        195                 200                 205             


Asp Gly Ile Lys Thr Ser Lys Ile Leu Glu Met Thr Asn Ile Asp Gly 
    210                 215                 220                 


Lys Ser Gln Phe Val Ser Tyr Glu Met Gln Arg Asn Leu Ser Leu Glu 
225                 230                 235                 240 


Asn Ala Lys Thr Ser Val Leu Leu Leu Asn Lys Val Asp Leu Leu Trp 
                245                 250                 255     


Asp Asp Leu Phe Leu Ile Leu Gln Phe Val Trp His Thr Ser Val Glu 
            260                 265                 270         


His Phe Gln Ile Arg Asn Val Thr Phe Gly Gly Lys Ala Tyr Leu Asp 
        275                 280                 285             


His Asn Ser Phe Asp Tyr Ser Asn Thr Val Met Arg Thr Ile Lys Leu 
    290                 295                 300                 


Glu His Val His Phe Arg Val Phe Tyr Ile Gln Gln Asp Lys Ile Tyr 
305                 310                 315                 320 


Leu Leu Leu Thr Lys Met Asp Ile Glu Asn Leu Thr Ile Ser Asn Ala 
                325                 330                 335     


Gln Met Pro His Met Leu Phe Pro Asn Tyr Pro Thr Lys Phe Gln Tyr 
            340                 345                 350         


Leu Asn Phe Ala Asn Asn Ile Leu Thr Asp Glu Leu Phe Lys Arg Thr 
        355                 360                 365             


Ile Gln Leu Pro His Leu Lys Thr Leu Ile Leu Asn Gly Asn Lys Leu 
    370                 375                 380                 


Glu Thr Leu Ser Leu Val Ser Cys Phe Ala Asn Asn Thr Pro Leu Glu 
385                 390                 395                 400 


His Leu Asp Leu Ser Gln Asn Leu Leu Gln His Lys Asn Asp Glu Asn 
                405                 410                 415     


Cys Ser Trp Pro Glu Thr Val Val Asn Met Asn Leu Ser Tyr Asn Lys 
            420                 425                 430         


Leu Ser Asp Ser Val Phe Arg Cys Leu Pro Lys Ser Ile Gln Ile Leu 
        435                 440                 445             


Asp Leu Asn Asn Asn Gln Ile Gln Thr Val Pro Lys Glu Thr Ile His 
    450                 455                 460                 


Leu Met Ala Leu Arg Glu Leu Asn Ile Ala Phe Asn Phe Leu Thr Asp 
465                 470                 475                 480 


Leu Pro Gly Cys Ser His Phe Ser Arg Leu Ser Val Leu Asn Ile Glu 
                485                 490                 495     


Met Asn Phe Ile Leu Ser Pro Ser Leu Asp Phe Val Gln Ser Cys Gln 
            500                 505                 510         


Glu Val Lys Thr Leu Asn Ala Gly Arg Asn Pro Phe Arg Cys Thr Cys 
        515                 520                 525             


Glu Leu Lys Asn Phe Ile Gln Leu Glu Thr Tyr Ser Glu Val Met Met 
    530                 535                 540                 


Val Gly Trp Ser Asp Ser Tyr Thr Cys Glu Tyr Pro Leu Asn Leu Arg 
545                 550                 555                 560 


Gly Thr Arg Leu Lys Asp Val His Leu His Glu Leu Ser Cys Asn Thr 
                565                 570                 575     


Ala Leu Leu Ile Val Thr Ile Val Val Ile Met Leu Val Leu Gly Leu 
            580                 585                 590         


Ala Val Ala Phe Cys Cys Leu His Phe Asp Leu Pro Trp Tyr Leu Arg 
        595                 600                 605             


Met Leu Gly Gln Cys Thr Gln Thr Trp His Arg Val Arg Lys Thr Thr 
    610                 615                 620                 


Gln Glu Gln Leu Lys Arg Asn Val Arg Phe His Ala Phe Ile Ser Tyr 
625                 630                 635                 640 


Ser Glu His Asp Ser Leu Trp Val Lys Asn Glu Leu Ile Pro Asn Leu 
                645                 650                 655     


Glu Lys Glu Asp Gly Ser Ile Leu Ile Cys Leu Tyr Glu Ser Tyr Phe 
            660                 665                 670         


Asp Pro Gly Lys Ser Ile Ser Glu Asn Ile Val Ser Phe Ile Glu Lys 
        675                 680                 685             


Ser Tyr Lys Ser Ile Phe Val Leu Ser Pro Asn Phe Val Gln Asn Glu 
    690                 695                 700                 


Trp Cys His Tyr Glu Phe Tyr Phe Ala His His Asn Leu Phe His Glu 
705                 710                 715                 720 


Asn Ser Asp His Ile Ile Leu Ile Leu Leu Glu Pro Ile Pro Phe Tyr 
                725                 730                 735     


Cys Ile Pro Thr Arg Tyr His Lys Leu Lys Ala Leu Leu Glu Lys Lys 
            740                 745                 750         


Ala Tyr Leu Glu Trp Pro Lys Asp Arg Arg Lys Cys Gly Leu Phe Trp 
        755                 760                 765             


Ala Asn Leu Arg Ala Ala Ile Asn Val Asn Val Leu Ala Thr Arg Glu 
    770                 775                 780                 


Met Tyr Glu Leu Gln Thr Phe Thr Glu Leu Asn Glu Glu Ser Arg Gly 
785                 790                 795                 800 


Ser Thr Ile Ser Leu Met Arg Thr Asp Cys Leu 
                805                 810     


<210>  49
<211>  509
<212>  PRT
<213>  Homo Sapiens

<400>  49

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210>  50
<211>  847
<212>  PRT
<213>  Homo Sapiens

<400>  50

Met His Leu Leu Gly Pro Trp Leu Leu Leu Leu Val Leu Glu Tyr Leu 
1               5                   10                  15      


Ala Phe Ser Asp Ser Ser Lys Trp Val Phe Glu His Pro Glu Thr Leu 
            20                  25                  30          


Tyr Ala Trp Glu Gly Ala Cys Val Trp Ile Pro Cys Thr Tyr Arg Ala 
        35                  40                  45              


Leu Asp Gly Asp Leu Glu Ser Phe Ile Leu Phe His Asn Pro Glu Tyr 
    50                  55                  60                  


Asn Lys Asn Thr Ser Lys Phe Asp Gly Thr Arg Leu Tyr Glu Ser Thr 
65                  70                  75                  80  


Lys Asp Gly Lys Val Pro Ser Glu Gln Lys Arg Val Gln Phe Leu Gly 
                85                  90                  95      


Asp Lys Asn Lys Asn Cys Thr Leu Ser Ile His Pro Val His Leu Asn 
            100                 105                 110         


Asp Ser Gly Gln Leu Gly Leu Arg Met Glu Ser Lys Thr Glu Lys Trp 
        115                 120                 125             


Met Glu Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro His 
    130                 135                 140                 


Ile Gln Leu Pro Pro Glu Ile Gln Glu Ser Gln Glu Val Thr Leu Thr 
145                 150                 155                 160 


Cys Leu Leu Asn Phe Ser Cys Tyr Gly Tyr Pro Ile Gln Leu Gln Trp 
                165                 170                 175     


Leu Leu Glu Gly Val Pro Met Arg Gln Ala Ala Val Thr Ser Thr Ser 
            180                 185                 190         


Leu Thr Ile Lys Ser Val Phe Thr Arg Ser Glu Leu Lys Phe Ser Pro 
        195                 200                 205             


Gln Trp Ser His His Gly Lys Ile Val Thr Cys Gln Leu Gln Asp Ala 
    210                 215                 220                 


Asp Gly Lys Phe Leu Ser Asn Asp Thr Val Gln Leu Asn Val Lys His 
225                 230                 235                 240 


Thr Pro Lys Leu Glu Ile Lys Val Thr Pro Ser Asp Ala Ile Val Arg 
                245                 250                 255     


Glu Gly Asp Ser Val Thr Met Thr Cys Glu Val Ser Ser Ser Asn Pro 
            260                 265                 270         


Glu Tyr Thr Thr Val Ser Trp Leu Lys Asp Gly Thr Ser Leu Lys Lys 
        275                 280                 285             


Gln Asn Thr Phe Thr Leu Asn Leu Arg Glu Val Thr Lys Asp Gln Ser 
    290                 295                 300                 


Gly Lys Tyr Cys Cys Gln Val Ser Asn Asp Val Gly Pro Gly Arg Ser 
305                 310                 315                 320 


Glu Glu Val Phe Leu Gln Val Gln Tyr Ala Pro Glu Pro Ser Thr Val 
                325                 330                 335     


Gln Ile Leu His Ser Pro Ala Val Glu Gly Ser Gln Val Glu Phe Leu 
            340                 345                 350         


Cys Met Ser Leu Ala Asn Pro Leu Pro Thr Asn Tyr Thr Trp Tyr His 
        355                 360                 365             


Asn Gly Lys Glu Met Gln Gly Arg Thr Glu Glu Lys Val His Ile Pro 
    370                 375                 380                 


Lys Ile Leu Pro Trp His Ala Gly Thr Tyr Ser Cys Val Ala Glu Asn 
385                 390                 395                 400 


Ile Leu Gly Thr Gly Gln Arg Gly Pro Gly Ala Glu Leu Asp Val Gln 
                405                 410                 415     


Tyr Pro Pro Lys Lys Val Thr Thr Val Ile Gln Asn Pro Met Pro Ile 
            420                 425                 430         


Arg Glu Gly Asp Thr Val Thr Leu Ser Cys Asn Tyr Asn Ser Ser Asn 
        435                 440                 445             


Pro Ser Val Thr Arg Tyr Glu Trp Lys Pro His Gly Ala Trp Glu Glu 
    450                 455                 460                 


Pro Ser Leu Gly Val Leu Lys Ile Gln Asn Val Gly Trp Asp Asn Thr 
465                 470                 475                 480 


Thr Ile Ala Cys Ala Ala Cys Asn Ser Trp Cys Ser Trp Ala Ser Pro 
                485                 490                 495     


Val Ala Leu Asn Val Gln Tyr Ala Pro Arg Asp Val Arg Val Arg Lys 
            500                 505                 510         


Ile Lys Pro Leu Ser Glu Ile His Ser Gly Asn Ser Val Ser Leu Gln 
        515                 520                 525             


Cys Asp Phe Ser Ser Ser His Pro Lys Glu Val Gln Phe Phe Trp Glu 
    530                 535                 540                 


Lys Asn Gly Arg Leu Leu Gly Lys Glu Ser Gln Leu Asn Phe Asp Ser 
545                 550                 555                 560 


Ile Ser Pro Glu Asp Ala Gly Ser Tyr Ser Cys Trp Val Asn Asn Ser 
                565                 570                 575     


Ile Gly Gln Thr Ala Ser Lys Ala Trp Thr Leu Glu Val Leu Tyr Ala 
            580                 585                 590         


Pro Arg Arg Leu Arg Val Ser Met Ser Pro Gly Asp Gln Val Met Glu 
        595                 600                 605             


Gly Lys Ser Ala Thr Leu Thr Cys Glu Ser Asp Ala Asn Pro Pro Val 
    610                 615                 620                 


Ser His Tyr Thr Trp Phe Asp Trp Asn Asn Gln Ser Leu Pro Tyr His 
625                 630                 635                 640 


Ser Gln Lys Leu Arg Leu Glu Pro Val Lys Val Gln His Ser Gly Ala 
                645                 650                 655     


Tyr Trp Cys Gln Gly Thr Asn Ser Val Gly Lys Gly Arg Ser Pro Leu 
            660                 665                 670         


Ser Thr Leu Thr Val Tyr Tyr Ser Pro Glu Thr Ile Gly Arg Arg Val 
        675                 680                 685             


Ala Val Gly Leu Gly Ser Cys Leu Ala Ile Leu Ile Leu Ala Ile Cys 
    690                 695                 700                 


Gly Leu Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly 
705                 710                 715                 720 


Leu Gln Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys 
                725                 730                 735     


Val Arg Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr 
            740                 745                 750         


Asn Pro Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro 
        755                 760                 765             


Glu Met Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln 
    770                 775                 780                 


Arg Pro Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His 
785                 790                 795                 800 


Lys Arg Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu 
                805                 810                 815     


Asp Glu Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu 
            820                 825                 830         


Arg Pro Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His 
        835                 840                 845         


<210>  51
<211>  807
<212>  PRT
<213>  Homo Sapiens

<400>  51

Met Asp Gln Arg Glu Ile Leu Gln Lys Phe Leu Asp Glu Ala Gln Ser 
1               5                   10                  15      


Lys Lys Ile Thr Lys Glu Glu Phe Ala Asn Glu Phe Leu Lys Leu Lys 
            20                  25                  30          


Arg Gln Ser Thr Lys Tyr Lys Ala Asp Lys Thr Tyr Pro Thr Thr Val 
        35                  40                  45              


Ala Glu Lys Pro Lys Asn Ile Lys Lys Asn Arg Tyr Lys Asp Ile Leu 
    50                  55                  60                  


Pro Tyr Asp Tyr Ser Arg Val Glu Leu Ser Leu Ile Thr Ser Asp Glu 
65                  70                  75                  80  


Asp Ser Ser Tyr Ile Asn Ala Asn Phe Ile Lys Gly Val Tyr Gly Pro 
                85                  90                  95      


Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu Ser Thr Thr Leu Leu Asp 
            100                 105                 110         


Phe Trp Arg Met Ile Trp Glu Tyr Ser Val Leu Ile Ile Val Met Ala 
        115                 120                 125             


Cys Met Glu Tyr Glu Met Gly Lys Lys Lys Cys Glu Arg Tyr Trp Ala 
    130                 135                 140                 


Glu Pro Gly Glu Met Gln Leu Glu Phe Gly Pro Phe Ser Val Ser Cys 
145                 150                 155                 160 


Glu Ala Glu Lys Arg Lys Ser Asp Tyr Ile Ile Arg Thr Leu Lys Val 
                165                 170                 175     


Lys Phe Asn Ser Glu Thr Arg Thr Ile Tyr Gln Phe His Tyr Lys Asn 
            180                 185                 190         


Trp Pro Asp His Asp Val Pro Ser Ser Ile Asp Pro Ile Leu Glu Leu 
        195                 200                 205             


Ile Trp Asp Val Arg Cys Tyr Gln Glu Asp Asp Ser Val Pro Ile Cys 
    210                 215                 220                 


Ile His Cys Ser Ala Gly Cys Gly Arg Thr Gly Val Ile Cys Ala Ile 
225                 230                 235                 240 


Asp Tyr Thr Trp Met Leu Leu Lys Asp Gly Ile Ile Pro Glu Asn Phe 
                245                 250                 255     


Ser Val Phe Ser Leu Ile Arg Glu Met Arg Thr Gln Arg Pro Ser Leu 
            260                 265                 270         


Val Gln Thr Gln Glu Gln Tyr Glu Leu Val Tyr Asn Ala Val Leu Glu 
        275                 280                 285             


Leu Phe Lys Arg Gln Met Asp Val Ile Arg Asp Lys His Ser Gly Thr 
    290                 295                 300                 


Glu Ser Gln Ala Lys His Cys Ile Pro Glu Lys Asn His Thr Leu Gln 
305                 310                 315                 320 


Ala Asp Ser Tyr Ser Pro Asn Leu Pro Lys Ser Thr Thr Lys Ala Ala 
                325                 330                 335     


Lys Met Met Asn Gln Gln Arg Thr Lys Met Glu Ile Lys Glu Ser Ser 
            340                 345                 350         


Ser Phe Asp Phe Arg Thr Ser Glu Ile Ser Ala Lys Glu Glu Leu Val 
        355                 360                 365             


Leu His Pro Ala Lys Ser Ser Thr Ser Phe Asp Phe Leu Glu Leu Asn 
    370                 375                 380                 


Tyr Ser Phe Asp Lys Asn Ala Asp Thr Thr Met Lys Trp Gln Thr Lys 
385                 390                 395                 400 


Ala Phe Pro Ile Val Gly Glu Pro Leu Gln Lys His Gln Ser Leu Asp 
                405                 410                 415     


Leu Gly Ser Leu Leu Phe Glu Gly Cys Ser Asn Ser Lys Pro Val Asn 
            420                 425                 430         


Ala Ala Gly Arg Tyr Phe Asn Ser Lys Val Pro Ile Thr Arg Thr Lys 
        435                 440                 445             


Ser Thr Pro Phe Glu Leu Ile Gln Gln Arg Glu Thr Lys Glu Val Asp 
    450                 455                 460                 


Ser Lys Glu Asn Phe Ser Tyr Leu Glu Ser Gln Pro His Asp Ser Cys 
465                 470                 475                 480 


Phe Val Glu Met Gln Ala Gln Lys Val Met His Val Ser Ser Ala Glu 
                485                 490                 495     


Leu Asn Tyr Ser Leu Pro Tyr Asp Ser Lys His Gln Ile Arg Asn Ala 
            500                 505                 510         


Ser Asn Val Lys His His Asp Ser Ser Ala Leu Gly Val Tyr Ser Tyr 
        515                 520                 525             


Ile Pro Leu Val Glu Asn Pro Tyr Phe Ser Ser Trp Pro Pro Ser Gly 
    530                 535                 540                 


Thr Ser Ser Lys Met Ser Leu Asp Leu Pro Glu Lys Gln Asp Gly Thr 
545                 550                 555                 560 


Val Phe Pro Ser Ser Leu Leu Pro Thr Ser Ser Thr Ser Leu Phe Ser 
                565                 570                 575     


Tyr Tyr Asn Ser His Asp Ser Leu Ser Leu Asn Ser Pro Thr Asn Ile 
            580                 585                 590         


Ser Ser Leu Leu Asn Gln Glu Ser Ala Val Leu Ala Thr Ala Pro Arg 
        595                 600                 605             


Ile Asp Asp Glu Ile Pro Pro Pro Leu Pro Val Arg Thr Pro Glu Ser 
    610                 615                 620                 


Phe Ile Val Val Glu Glu Ala Gly Glu Phe Ser Pro Asn Val Pro Lys 
625                 630                 635                 640 


Ser Leu Ser Ser Ala Val Lys Val Lys Ile Gly Thr Ser Leu Glu Trp 
                645                 650                 655     


Gly Gly Thr Ser Glu Pro Lys Lys Phe Asp Asp Ser Val Ile Leu Arg 
            660                 665                 670         


Pro Ser Lys Ser Val Lys Leu Arg Ser Pro Lys Ser Glu Leu His Gln 
        675                 680                 685             


Asp Arg Ser Ser Pro Pro Pro Pro Leu Pro Glu Arg Thr Leu Glu Ser 
    690                 695                 700                 


Phe Phe Leu Ala Asp Glu Asp Cys Met Gln Ala Gln Ser Ile Glu Thr 
705                 710                 715                 720 


Tyr Ser Thr Ser Tyr Pro Asp Thr Met Glu Asn Ser Thr Ser Ser Lys 
                725                 730                 735     


Gln Thr Leu Lys Thr Pro Gly Lys Ser Phe Thr Arg Ser Lys Ser Leu 
            740                 745                 750         


Lys Ile Leu Arg Asn Met Lys Lys Ser Ile Cys Asn Ser Cys Pro Pro 
        755                 760                 765             


Asn Lys Pro Ala Glu Ser Val Gln Ser Asn Asn Ser Ser Ser Phe Leu 
    770                 775                 780                 


Asn Phe Gly Phe Ala Asn Arg Phe Ser Lys Pro Lys Gly Pro Arg Asn 
785                 790                 795                 800 


Pro Pro Pro Thr Trp Asn Ile 
                805         


<210>  52
<211>  706
<212>  PRT
<213>  Homo Sapiens

<400>  52

Met Ala Ser Pro Ala Asp Ser Cys Ile Gln Phe Thr Arg His Ala Ser 
1               5                   10                  15      


Asp Val Leu Leu Asn Leu Asn Arg Leu Arg Ser Arg Asp Ile Leu Thr 
            20                  25                  30          


Asp Val Val Ile Val Val Ser Arg Glu Gln Phe Arg Ala His Lys Thr 
        35                  40                  45              


Val Leu Met Ala Cys Ser Gly Leu Phe Tyr Ser Ile Phe Thr Asp Gln 
    50                  55                  60                  


Leu Lys Cys Asn Leu Ser Val Ile Asn Leu Asp Pro Glu Ile Asn Pro 
65                  70                  75                  80  


Glu Gly Phe Cys Ile Leu Leu Asp Phe Met Tyr Thr Ser Arg Leu Asn 
                85                  90                  95      


Leu Arg Glu Gly Asn Ile Met Ala Val Met Ala Thr Ala Met Tyr Leu 
            100                 105                 110         


Gln Met Glu His Val Val Asp Thr Cys Arg Lys Phe Ile Lys Ala Ser 
        115                 120                 125             


Glu Ala Glu Met Val Ser Ala Ile Lys Pro Pro Arg Glu Glu Phe Leu 
    130                 135                 140                 


Asn Ser Arg Met Leu Met Pro Gln Asp Ile Met Ala Tyr Arg Gly Arg 
145                 150                 155                 160 


Glu Val Val Glu Asn Asn Leu Pro Leu Arg Ser Ala Pro Gly Cys Glu 
                165                 170                 175     


Ser Arg Ala Phe Ala Pro Ser Leu Tyr Ser Gly Leu Ser Thr Pro Pro 
            180                 185                 190         


Ala Ser Tyr Ser Met Tyr Ser His Leu Pro Val Ser Ser Leu Leu Phe 
        195                 200                 205             


Ser Asp Glu Glu Phe Arg Asp Val Arg Met Pro Val Ala Asn Pro Phe 
    210                 215                 220                 


Pro Lys Glu Arg Ala Leu Pro Cys Asp Ser Ala Arg Pro Val Pro Gly 
225                 230                 235                 240 


Glu Tyr Ser Arg Pro Thr Leu Glu Val Ser Pro Asn Val Cys His Ser 
                245                 250                 255     


Asn Ile Tyr Ser Pro Lys Glu Thr Ile Pro Glu Glu Ala Arg Ser Asp 
            260                 265                 270         


Met His Tyr Ser Val Ala Glu Gly Leu Lys Pro Ala Ala Pro Ser Ala 
        275                 280                 285             


Arg Asn Ala Pro Tyr Phe Pro Cys Asp Lys Ala Ser Lys Glu Glu Glu 
    290                 295                 300                 


Arg Pro Ser Ser Glu Asp Glu Ile Ala Leu His Phe Glu Pro Pro Asn 
305                 310                 315                 320 


Ala Pro Leu Asn Arg Lys Gly Leu Val Ser Pro Gln Ser Pro Gln Lys 
                325                 330                 335     


Ser Asp Cys Gln Pro Asn Ser Pro Thr Glu Ser Cys Ser Ser Lys Asn 
            340                 345                 350         


Ala Cys Ile Leu Gln Ala Ser Gly Ser Pro Pro Ala Lys Ser Pro Thr 
        355                 360                 365             


Asp Pro Lys Ala Cys Asn Trp Lys Lys Tyr Lys Phe Ile Val Leu Asn 
    370                 375                 380                 


Ser Leu Asn Gln Asn Ala Lys Pro Glu Gly Pro Glu Gln Ala Glu Leu 
385                 390                 395                 400 


Gly Arg Leu Ser Pro Arg Ala Tyr Thr Ala Pro Pro Ala Cys Gln Pro 
                405                 410                 415     


Pro Met Glu Pro Glu Asn Leu Asp Leu Gln Ser Pro Thr Lys Leu Ser 
            420                 425                 430         


Ala Ser Gly Glu Asp Ser Thr Ile Pro Gln Ala Ser Arg Leu Asn Asn 
        435                 440                 445             


Ile Val Asn Arg Ser Met Thr Gly Ser Pro Arg Ser Ser Ser Glu Ser 
    450                 455                 460                 


His Ser Pro Leu Tyr Met His Pro Pro Lys Cys Thr Ser Cys Gly Ser 
465                 470                 475                 480 


Gln Ser Pro Gln His Ala Glu Met Cys Leu His Thr Ala Gly Pro Thr 
                485                 490                 495     


Phe Pro Glu Glu Met Gly Glu Thr Gln Ser Glu Tyr Ser Asp Ser Ser 
            500                 505                 510         


Cys Glu Asn Gly Ala Phe Phe Cys Asn Glu Cys Asp Cys Arg Phe Ser 
        515                 520                 525             


Glu Glu Ala Ser Leu Lys Arg His Thr Leu Gln Thr His Ser Asp Lys 
    530                 535                 540                 


Pro Tyr Lys Cys Asp Arg Cys Gln Ala Ser Phe Arg Tyr Lys Gly Asn 
545                 550                 555                 560 


Leu Ala Ser His Lys Thr Val His Thr Gly Glu Lys Pro Tyr Arg Cys 
                565                 570                 575     


Asn Ile Cys Gly Ala Gln Phe Asn Arg Pro Ala Asn Leu Lys Thr His 
            580                 585                 590         


Thr Arg Ile His Ser Gly Glu Lys Pro Tyr Lys Cys Glu Thr Cys Gly 
        595                 600                 605             


Ala Arg Phe Val Gln Val Ala His Leu Arg Ala His Val Leu Ile His 
    610                 615                 620                 


Thr Gly Glu Lys Pro Tyr Pro Cys Glu Ile Cys Gly Thr Arg Phe Arg 
625                 630                 635                 640 


His Leu Gln Thr Leu Lys Ser His Leu Arg Ile His Thr Gly Glu Lys 
                645                 650                 655     


Pro Tyr His Cys Glu Lys Cys Asn Leu His Phe Arg His Lys Ser Gln 
            660                 665                 670         


Leu Arg Leu His Leu Arg Gln Lys His Gly Ala Ile Thr Asn Thr Lys 
        675                 680                 685             


Val Gln Tyr Arg Val Ser Ala Thr Asp Leu Pro Pro Glu Leu Pro Lys 
    690                 695                 700                 


Ala Cys 
705     


<210>  53
<211>  263
<212>  PRT
<213>  Homo Sapiens

<400>  53

Met Leu Leu Ala Trp Val Gln Ala Phe Leu Val Ser Asn Met Leu Leu 
1               5                   10                  15      


Ala Glu Ala Tyr Gly Ser Gly Gly Cys Phe Trp Asp Asn Gly His Leu 
            20                  25                  30          


Tyr Arg Glu Asp Gln Thr Ser Pro Ala Pro Gly Leu Arg Cys Leu Asn 
        35                  40                  45              


Trp Leu Asp Ala Gln Ser Gly Leu Ala Ser Ala Pro Val Ser Gly Ala 
    50                  55                  60                  


Gly Asn His Ser Tyr Cys Arg Asn Pro Asp Glu Asp Pro Arg Gly Pro 
65                  70                  75                  80  


Trp Cys Tyr Val Ser Gly Glu Ala Gly Val Pro Glu Lys Arg Pro Cys 
                85                  90                  95      


Glu Asp Leu Arg Cys Pro Glu Thr Thr Ser Gln Ala Leu Pro Ala Phe 
            100                 105                 110         


Thr Thr Glu Ile Gln Glu Ala Ser Glu Gly Pro Gly Ala Asp Glu Val 
        115                 120                 125             


Gln Val Phe Ala Pro Ala Asn Ala Leu Pro Ala Arg Ser Glu Ala Ala 
    130                 135                 140                 


Ala Val Gln Pro Val Ile Gly Ile Ser Gln Arg Val Arg Met Asn Ser 
145                 150                 155                 160 


Lys Glu Lys Lys Asp Leu Gly Thr Leu Gly Tyr Val Leu Gly Ile Thr 
                165                 170                 175     


Met Met Val Ile Ile Ile Ala Ile Gly Ala Gly Ile Ile Leu Gly Tyr 
            180                 185                 190         


Ser Tyr Lys Arg Gly Lys Asp Leu Lys Glu Gln His Asp Gln Lys Val 
        195                 200                 205             


Cys Glu Arg Glu Met Gln Arg Ile Thr Leu Pro Leu Ser Ala Phe Thr 
    210                 215                 220                 


Asn Pro Thr Cys Glu Ile Val Asp Glu Lys Thr Val Val Val His Thr 
225                 230                 235                 240 


Ser Gln Thr Pro Val Asp Pro Gln Glu Gly Thr Thr Pro Leu Met Gly 
                245                 250                 255     


Gln Ala Gly Thr Pro Gly Ala 
            260             


<210>  54
<211>  156
<212>  PRT
<213>  Homo Sapiens

<400>  54

Met Glu Pro Ala Ala Gly Ser Ser Met Glu Pro Ser Ala Asp Trp Leu 
1               5                   10                  15      


Ala Thr Ala Ala Ala Arg Gly Arg Val Glu Glu Val Arg Ala Leu Leu 
            20                  25                  30          


Glu Ala Gly Ala Leu Pro Asn Ala Pro Asn Ser Tyr Gly Arg Arg Pro 
        35                  40                  45              


Ile Gln Val Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu 
    50                  55                  60                  


Leu His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg 
65                  70                  75                  80  


Pro Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val 
                85                  90                  95      


Leu His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg 
            100                 105                 110         


Leu Pro Val Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg 
        115                 120                 125             


Tyr Leu Arg Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg 
    130                 135                 140                 


Ile Asp Ala Ala Glu Gly Pro Ser Asp Ile Pro Asp 
145                 150                 155     


<210>  55
<211>  1226
<212>  PRT
<213>  Homo Sapiens

<400>  55

Met Asp Ser Phe Asp Leu Ala Leu Leu Gln Glu Trp Asp Leu Glu Ser 
1               5                   10                  15      


Leu Cys Val Tyr Glu Pro Asp Arg Asn Ala Leu Arg Arg Lys Glu Arg 
            20                  25                  30          


Glu Arg Arg Asn Gln Glu Thr Gln Gln Asp Asp Gly Thr Phe Asn Ser 
        35                  40                  45              


Ser Tyr Ser Leu Phe Ser Glu Pro Tyr Lys Thr Asn Lys Gly Asp Glu 
    50                  55                  60                  


Leu Ser Asn Arg Ile Gln Asn Thr Leu Gly Asn Tyr Asp Glu Met Lys 
65                  70                  75                  80  


Asp Phe Leu Thr Asp Arg Ser Asn Gln Ser His Leu Val Gly Val Pro 
                85                  90                  95      


Lys Pro Gly Val Pro Gln Thr Pro Val Asn Lys Ile Asp Glu His Phe 
            100                 105                 110         


Val Ala Asp Ser Arg Ala Gln Asn Gln Pro Ser Ser Ile Cys Ser Thr 
        115                 120                 125             


Thr Thr Ser Thr Pro Ala Ala Val Pro Val Gln Gln Ser Lys Arg Gly 
    130                 135                 140                 


Thr Met Gly Trp Gln Lys Ala Gly His Pro Pro Ser Asp Gly Gln Gln 
145                 150                 155                 160 


Arg Ala Thr Gln Gln Gly Ser Leu Arg Thr Leu Leu Gly Asp Gly Val 
                165                 170                 175     


Gly Arg Gln Gln Pro Arg Ala Lys Gln Val Cys Asn Val Glu Val Gly 
            180                 185                 190         


Leu Gln Thr Gln Glu Arg Pro Pro Ala Met Ala Ala Lys His Ser Ser 
        195                 200                 205             


Ser Gly His Cys Val Gln Asn Phe Pro Pro Ser Leu Ala Ser Lys Pro 
    210                 215                 220                 


Ser Leu Val Gln Gln Lys Pro Thr Ala Tyr Val Arg Pro Met Asp Gly 
225                 230                 235                 240 


Gln Asp Gln Ala Pro Asp Glu Ser Pro Lys Leu Lys Ser Ser Ser Glu 
                245                 250                 255     


Thr Ser Val His Cys Thr Ser Tyr Arg Gly Val Pro Ala Ser Lys Pro 
            260                 265                 270         


Glu Pro Ala Arg Ala Lys Ala Lys Leu Ser Lys Phe Ser Ile Pro Lys 
        275                 280                 285             


Gln Gly Glu Glu Ser Arg Ser Gly Glu Thr Asn Ser Cys Val Glu Glu 
    290                 295                 300                 


Ile Ile Arg Glu Met Thr Trp Leu Pro Pro Leu Ser Ala Ile Gln Ala 
305                 310                 315                 320 


Pro Gly Lys Val Glu Pro Thr Lys Phe Pro Phe Pro Asn Lys Asp Ser 
                325                 330                 335     


Gln Leu Val Ser Ser Gly His Asn Asn Pro Lys Lys Gly Asp Ala Glu 
            340                 345                 350         


Pro Glu Ser Pro Asp Ser Gly Thr Ser Asn Thr Ser Met Leu Glu Asp 
        355                 360                 365             


Asp Leu Lys Leu Ser Ser Asp Glu Glu Glu Asn Glu Gln Gln Ala Ala 
    370                 375                 380                 


Gln Arg Thr Ala Leu Arg Ala Leu Ser Asp Ser Ala Val Val Gln Gln 
385                 390                 395                 400 


Pro Asn Cys Arg Thr Ser Val Pro Ser Ser Lys Gly Ser Ser Ser Ser 
                405                 410                 415     


Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Asp Ser Glu Ser Ser Ser 
            420                 425                 430         


Gly Ser Asp Ser Glu Thr Glu Ser Ser Ser Ser Glu Ser Glu Gly Ser 
        435                 440                 445             


Lys Pro Pro His Phe Ser Ser Pro Glu Ala Glu Pro Ala Ser Ser Asn 
    450                 455                 460                 


Lys Trp Gln Leu Asp Lys Trp Leu Asn Lys Val Asn Pro His Lys Pro 
465                 470                 475                 480 


Pro Ile Leu Ile Gln Asn Glu Ser His Gly Ser Glu Ser Asn Gln Tyr 
                485                 490                 495     


Tyr Asn Pro Val Lys Glu Asp Val Gln Asp Cys Gly Lys Val Pro Asp 
            500                 505                 510         


Val Cys Gln Pro Ser Leu Arg Glu Lys Glu Ile Lys Ser Thr Cys Lys 
        515                 520                 525             


Glu Glu Gln Arg Pro Arg Thr Ala Asn Lys Ala Pro Gly Ser Lys Gly 
    530                 535                 540                 


Val Lys Gln Lys Ser Pro Pro Ala Ala Val Ala Val Ala Val Ser Ala 
545                 550                 555                 560 


Ala Ala Pro Pro Pro Ala Val Pro Cys Ala Pro Ala Glu Asn Ala Pro 
                565                 570                 575     


Ala Pro Ala Arg Arg Ser Ala Gly Lys Lys Pro Thr Arg Arg Thr Glu 
            580                 585                 590         


Arg Thr Ser Ala Gly Asp Gly Ala Asn Cys His Arg Pro Glu Glu Pro 
        595                 600                 605             


Ala Ala Ala Asp Ala Leu Gly Thr Ser Val Val Val Pro Pro Glu Pro 
    610                 615                 620                 


Thr Lys Thr Arg Pro Cys Gly Asn Asn Arg Ala Ser His Arg Lys Glu 
625                 630                 635                 640 


Leu Arg Ser Ser Val Thr Cys Glu Lys Arg Arg Thr Arg Gly Leu Ser 
                645                 650                 655     


Arg Ile Val Pro Lys Ser Lys Glu Phe Ile Glu Thr Glu Ser Ser Ser 
            660                 665                 670         


Ser Ser Ser Ser Ser Asp Ser Asp Leu Glu Ser Glu Gln Glu Glu Tyr 
        675                 680                 685             


Pro Leu Ser Lys Ala Gln Thr Val Ala Ala Ser Ala Ser Ser Gly Asn 
    690                 695                 700                 


Asp Gln Arg Leu Lys Glu Ala Ala Ala Asn Gly Gly Ser Gly Pro Arg 
705                 710                 715                 720 


Ala Pro Val Gly Ser Ile Asn Ala Arg Thr Thr Ser Asp Ile Ala Lys 
                725                 730                 735     


Glu Leu Glu Glu Gln Phe Tyr Thr Leu Val Pro Phe Gly Arg Asn Glu 
            740                 745                 750         


Leu Leu Ser Pro Leu Lys Asp Ser Asp Glu Ile Arg Ser Leu Trp Val 
        755                 760                 765             


Lys Ile Asp Leu Thr Leu Leu Ser Arg Ile Pro Glu His Leu Pro Gln 
    770                 775                 780                 


Glu Pro Gly Val Leu Ser Ala Pro Ala Thr Lys Asp Ser Glu Ser Ala 
785                 790                 795                 800 


Pro Pro Ser His Thr Ser Asp Thr Pro Ala Glu Lys Ala Leu Pro Lys 
                805                 810                 815     


Ser Lys Arg Lys Arg Lys Cys Asp Asn Glu Asp Asp Tyr Arg Glu Ile 
            820                 825                 830         


Lys Lys Ser Gln Gly Glu Lys Asp Ser Ser Ser Arg Leu Ala Thr Ser 
        835                 840                 845             


Thr Ser Asn Thr Leu Ser Ala Asn His Cys Asn Met Asn Ile Asn Ser 
    850                 855                 860                 


Val Ala Ile Pro Ile Asn Lys Asn Glu Lys Met Leu Arg Ser Pro Ile 
865                 870                 875                 880 


Ser Pro Leu Ser Asp Ala Ser Lys His Lys Tyr Thr Ser Glu Asp Leu 
                885                 890                 895     


Thr Ser Ser Ser Arg Pro Asn Gly Asn Ser Leu Phe Thr Ser Ala Ser 
            900                 905                 910         


Ser Ser Lys Lys Pro Lys Ala Asp Ser Gln Leu Gln Pro His Gly Gly 
        915                 920                 925             


Asp Leu Thr Lys Ala Ala His Asn Asn Ser Glu Asn Ile Pro Leu His 
    930                 935                 940                 


Lys Ser Arg Pro Gln Thr Lys Pro Trp Ser Pro Gly Ser Asn Gly His 
945                 950                 955                 960 


Arg Asp Cys Lys Arg Gln Lys Leu Val Phe Asp Asp Met Pro Arg Ser 
                965                 970                 975     


Ala Asp Tyr Phe Met Gln Glu Ala Lys Arg Met Lys His Lys Ala Asp 
            980                 985                 990         


Ala Met Val Glu Lys Phe Gly Lys  Ala Leu Asn Tyr Ala  Glu Ala Ala 
        995                 1000                 1005             


Leu Ser  Phe Ile Glu Cys Gly  Asn Ala Met Glu Gln  Gly Pro Met 
    1010                 1015                 1020             


Glu Ser  Lys Ser Pro Tyr Thr  Met Tyr Ser Glu Thr  Val Glu Leu 
    1025                 1030                 1035             


Ile Arg  Tyr Ala Met Arg Leu  Lys Thr His Ser Gly  Pro Asn Ala 
    1040                 1045                 1050             


Thr Pro  Glu Asp Lys Gln Leu  Ala Ala Leu Cys Tyr  Arg Cys Leu 
    1055                 1060                 1065             


Ala Leu  Leu Tyr Trp Arg Met  Phe Arg Leu Lys Arg  Asp His Ala 
    1070                 1075                 1080             


Val Lys  Tyr Ser Lys Ala Leu  Ile Asp Tyr Phe Lys  Asn Ser Ser 
    1085                 1090                 1095             


Lys Ala  Ala Gln Ala Pro Ser  Pro Trp Gly Ala Ser  Gly Lys Ser 
    1100                 1105                 1110             


Thr Gly  Thr Pro Ser Pro Met  Ser Pro Asn Pro Ser  Pro Ala Ser 
    1115                 1120                 1125             


Ser Val  Gly Ser Gln Gly Ser  Leu Ser Asn Ala Ser  Ala Leu Ser 
    1130                 1135                 1140             


Pro Ser  Thr Ile Val Ser Ile  Pro Gln Arg Ile His  Gln Met Ala 
    1145                 1150                 1155             


Ala Asn  His Val Ser Ile Thr  Asn Ser Ile Leu His  Ser Tyr Asp 
    1160                 1165                 1170             


Tyr Trp  Glu Met Ala Asp Asn  Leu Ala Lys Glu Asn  Arg Glu Phe 
    1175                 1180                 1185             


Phe Asn  Asp Leu Asp Leu Leu  Met Gly Pro Val Thr  Leu His Ser 
    1190                 1195                 1200             


Ser Met  Glu His Leu Val Gln  Tyr Ser Gln Gln Gly  Leu His Trp 
    1205                 1210                 1215             


Leu Arg  Asn Ser Ala His Leu  Ser 
    1220                 1225     


<210>  56
<211>  404
<212>  PRT
<213>  Homo Sapiens

<400>  56

Met Pro His Glu Pro His Glu Pro Leu Thr Pro Pro Phe Ser Ala Leu 
1               5                   10                  15      


Pro Asp Pro Ala Gly Ala Pro Ser Arg Arg Gln Ser Arg Gln Arg Pro 
            20                  25                  30          


Gln Leu Ser Ser Asp Ser Pro Ser Ala Phe Arg Ala Ser Arg Ser His 
        35                  40                  45              


Ser Arg Asn Ala Thr Arg Ser His Ser His Ser His Ser Pro Arg His 
    50                  55                  60                  


Ser Leu Arg His Ser Pro Gly Ser Gly Ser Cys Gly Ser Ser Ser Gly 
65                  70                  75                  80  


His Arg Pro Cys Ala Asp Ile Leu Glu Val Gly Met Leu Leu Ser Lys 
                85                  90                  95      


Ile Asn Ser Leu Ala His Leu Arg Ala Ala Pro Cys Asn Asp Leu His 
            100                 105                 110         


Ala Thr Lys Leu Ala Pro Gly Lys Glu Lys Glu Pro Leu Glu Ser Gln 
        115                 120                 125             


Tyr Gln Val Gly Pro Leu Leu Gly Ser Gly Gly Phe Gly Ser Val Tyr 
    130                 135                 140                 


Ser Gly Ile Arg Val Ser Asp Asn Leu Pro Val Ala Ile Lys His Val 
145                 150                 155                 160 


Glu Lys Asp Arg Ile Ser Asp Trp Gly Glu Leu Pro Asn Gly Thr Arg 
                165                 170                 175     


Val Pro Met Glu Val Val Leu Leu Lys Lys Val Ser Ser Gly Phe Ser 
            180                 185                 190         


Gly Val Ile Arg Leu Leu Asp Trp Phe Glu Arg Pro Asp Ser Phe Val 
        195                 200                 205             


Leu Ile Leu Glu Arg Pro Glu Pro Val Gln Asp Leu Phe Asp Phe Ile 
    210                 215                 220                 


Thr Glu Arg Gly Ala Leu Gln Glu Glu Leu Ala Arg Ser Phe Phe Trp 
225                 230                 235                 240 


Gln Val Leu Glu Ala Val Arg His Cys His Asn Cys Gly Val Leu His 
                245                 250                 255     


Arg Asp Ile Lys Asp Glu Asn Ile Leu Ile Asp Leu Asn Arg Gly Glu 
            260                 265                 270         


Leu Lys Leu Ile Asp Phe Gly Ser Gly Ala Leu Leu Lys Asp Thr Val 
        275                 280                 285             


Tyr Thr Asp Phe Asp Gly Thr Arg Val Tyr Ser Pro Pro Glu Trp Ile 
    290                 295                 300                 


Arg Tyr His Arg Tyr His Gly Arg Ser Ala Ala Val Trp Ser Leu Gly 
305                 310                 315                 320 


Ile Leu Leu Tyr Asp Met Val Cys Gly Asp Ile Pro Phe Glu His Asp 
                325                 330                 335     


Glu Glu Ile Ile Arg Gly Gln Val Phe Phe Arg Gln Arg Val Ser Ser 
            340                 345                 350         


Glu Cys Gln His Leu Ile Arg Trp Cys Leu Ala Leu Arg Pro Ser Asp 
        355                 360                 365             


Arg Pro Thr Phe Glu Glu Ile Gln Asn His Pro Trp Met Gln Asp Val 
    370                 375                 380                 


Leu Leu Pro Gln Glu Thr Ala Glu Ile His Leu His Ser Leu Ser Pro 
385                 390                 395                 400 


Gly Pro Ser Lys 
                


<210>  57
<211>  207
<212>  PRT
<213>  Homo Sapiens

<400>  57

Met Asp Lys Asp Cys Glu Met Lys Arg Thr Thr Leu Asp Ser Pro Leu 
1               5                   10                  15      


Gly Lys Leu Glu Leu Ser Gly Cys Glu Gln Gly Leu His Glu Ile Lys 
            20                  25                  30          


Leu Leu Gly Lys Gly Thr Ser Ala Ala Asp Ala Val Glu Val Pro Ala 
        35                  40                  45              


Pro Ala Ala Val Leu Gly Gly Pro Glu Pro Leu Met Gln Cys Thr Ala 
    50                  55                  60                  


Trp Leu Asn Ala Tyr Phe His Gln Pro Glu Ala Ile Glu Glu Phe Pro 
65                  70                  75                  80  


Val Pro Ala Leu His His Pro Val Phe Gln Gln Glu Ser Phe Thr Arg 
                85                  90                  95      


Gln Val Leu Trp Lys Leu Leu Lys Val Val Lys Phe Gly Glu Val Ile 
            100                 105                 110         


Ser Tyr Gln Gln Leu Ala Ala Leu Ala Gly Asn Pro Lys Ala Ala Arg 
        115                 120                 125             


Ala Val Gly Gly Ala Met Arg Gly Asn Pro Val Pro Ile Leu Ile Pro 
    130                 135                 140                 


Cys His Arg Val Val Cys Ser Ser Gly Ala Val Gly Asn Tyr Ser Gly 
145                 150                 155                 160 


Gly Leu Ala Val Lys Glu Trp Leu Leu Ala His Glu Gly His Arg Leu 
                165                 170                 175     


Gly Lys Pro Gly Leu Gly Gly Ser Ser Gly Leu Ala Gly Ala Trp Leu 
            180                 185                 190         


Lys Gly Ala Gly Ala Thr Ser Gly Ser Pro Pro Ala Gly Arg Asn 
        195                 200                 205         


<210>  58
<211>  736
<212>  PRT
<213>  Homo Sapiens

<400>  58

Met Lys Lys Ser Arg Ser Val Met Thr Val Met Ala Asp Asp Asn Val 
1               5                   10                  15      


Lys Asp Tyr Phe Glu Cys Ser Leu Ser Lys Ser Tyr Ser Ser Ser Ser 
            20                  25                  30          


Asn Thr Leu Gly Ile Asp Leu Trp Arg Gly Arg Arg Cys Cys Ser Gly 
        35                  40                  45              


Asn Leu Gln Leu Pro Pro Leu Ser Gln Arg Gln Ser Glu Arg Ala Arg 
    50                  55                  60                  


Thr Pro Glu Gly Asp Gly Ile Ser Arg Pro Thr Thr Leu Pro Leu Thr 
65                  70                  75                  80  


Thr Leu Pro Ser Ile Ala Ile Thr Thr Val Ser Gln Glu Cys Phe Asp 
                85                  90                  95      


Val Glu Asn Gly Pro Ser Pro Gly Arg Ser Pro Leu Asp Pro Gln Ala 
            100                 105                 110         


Ser Ser Ser Ala Gly Leu Val Leu His Ala Thr Phe Pro Gly His Ser 
        115                 120                 125             


Gln Arg Arg Glu Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp Leu 
    130                 135                 140                 


Ser Pro Lys Ala Met Ser Arg Asn Ser Ser Leu Pro Ser Glu Gln His 
145                 150                 155                 160 


Gly Asp Asp Leu Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser Leu 
                165                 170                 175     


Arg Ser Val Arg Asn Asn Phe Thr Ile Leu Thr Asn Leu His Gly Thr 
            180                 185                 190         


Ser Asn Lys Arg Ser Pro Ala Ala Ser Gln Pro Pro Val Ser Arg Val 
        195                 200                 205             


Asn Pro Gln Glu Glu Ser Tyr Gln Lys Leu Ala Met Glu Thr Leu Glu 
    210                 215                 220                 


Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu Thr Ile Gln Thr Tyr Arg 
225                 230                 235                 240 


Ser Val Ser Glu Met Ala Ser Asn Lys Phe Lys Arg Met Leu Asn Arg 
                245                 250                 255     


Glu Leu Thr His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser 
            260                 265                 270         


Glu Tyr Ile Ser Asn Thr Phe Leu Asp Lys Gln Asn Asp Val Glu Ile 
        275                 280                 285             


Pro Ser Pro Thr Gln Lys Asp Arg Glu Lys Lys Lys Lys Gln Gln Leu 
    290                 295                 300                 


Met Thr Gln Ile Ser Gly Val Lys Lys Leu Met His Ser Ser Ser Leu 
305                 310                 315                 320 


Asn Asn Thr Ser Ile Ser Arg Phe Gly Val Asn Thr Glu Asn Glu Asp 
                325                 330                 335     


His Leu Ala Lys Glu Leu Glu Asp Leu Asn Lys Trp Gly Leu Asn Ile 
            340                 345                 350         


Phe Asn Val Ala Gly Tyr Ser His Asn Arg Pro Leu Thr Cys Ile Met 
        355                 360                 365             


Tyr Ala Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr Phe Arg Ile Ser 
    370                 375                 380                 


Ser Asp Thr Phe Ile Thr Tyr Met Met Thr Leu Glu Asp His Tyr His 
385                 390                 395                 400 


Ser Asp Val Ala Tyr His Asn Ser Leu His Ala Ala Asp Val Ala Gln 
                405                 410                 415     


Ser Thr His Val Leu Leu Ser Thr Pro Ala Leu Asp Ala Val Phe Thr 
            420                 425                 430         


Asp Leu Glu Ile Leu Ala Ala Ile Phe Ala Ala Ala Ile His Asp Val 
        435                 440                 445             


Asp His Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu 
    450                 455                 460                 


Leu Ala Leu Met Tyr Asn Asp Glu Ser Val Leu Glu Asn His His Leu 
465                 470                 475                 480 


Ala Val Gly Phe Lys Leu Leu Gln Glu Glu His Cys Asp Ile Phe Met 
                485                 490                 495     


Asn Leu Thr Lys Lys Gln Arg Gln Thr Leu Arg Lys Met Val Ile Asp 
            500                 505                 510         


Met Val Leu Ala Thr Asp Met Ser Lys His Met Ser Leu Leu Ala Asp 
        515                 520                 525             


Leu Lys Thr Met Val Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu 
    530                 535                 540                 


Leu Leu Asp Asn Tyr Thr Asp Arg Ile Gln Val Leu Arg Asn Met Val 
545                 550                 555                 560 


His Cys Ala Asp Leu Ser Asn Pro Thr Lys Ser Leu Glu Leu Tyr Arg 
                565                 570                 575     


Gln Trp Thr Asp Arg Ile Met Glu Glu Phe Phe Gln Gln Gly Asp Lys 
            580                 585                 590         


Glu Arg Glu Arg Gly Met Glu Ile Ser Pro Met Cys Asp Lys His Thr 
        595                 600                 605             


Ala Ser Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His 
    610                 615                 620                 


Pro Leu Trp Glu Thr Trp Ala Asp Leu Val Gln Pro Asp Ala Gln Asp 
625                 630                 635                 640 


Ile Leu Asp Thr Leu Glu Asp Asn Arg Asn Trp Tyr Gln Ser Met Ile 
                645                 650                 655     


Pro Gln Ser Pro Ser Pro Pro Leu Asp Glu Gln Asn Arg Asp Cys Gln 
            660                 665                 670         


Gly Leu Met Glu Lys Phe Gln Phe Glu Leu Thr Leu Asp Glu Glu Asp 
        675                 680                 685             


Ser Glu Gly Pro Glu Lys Glu Gly Glu Gly His Ser Tyr Phe Ser Ser 
    690                 695                 700                 


Thr Lys Thr Leu Cys Val Ile Asp Pro Glu Asn Arg Asp Ser Leu Gly 
705                 710                 715                 720 


Glu Thr Asp Ile Asp Ile Ala Thr Glu Asp Lys Ser Pro Val Asp Thr 
                725                 730                 735     


<210>  59
<211>  500
<212>  PRT
<213>  Homo Sapiens

<400>  59

Met Asn Gln Arg Arg Ser Glu Ser Arg Pro Gly Asn His Arg Leu Gln 
1               5                   10                  15      


Ala Tyr Ala Glu Pro Gly Lys Gly Asp Ser Gly Gly Ala Gly Pro Leu 
            20                  25                  30          


Ser Gly Ser Ala Arg Arg Gly Arg Gly Gly Gly Gly Ala Ile Arg Val 
        35                  40                  45              


Arg Arg Pro Cys Trp Ser Gly Gly Ala Gly Arg Gly Gly Gly Pro Ala 
    50                  55                  60                  


Trp Ala Val Arg Leu Pro Thr Val Thr Ala Gly Trp Thr Trp Pro Ala 
65                  70                  75                  80  


Leu Arg Thr Leu Ser Ser Leu Arg Ala Gly Pro Ser Glu Pro His Ser 
                85                  90                  95      


Pro Gly Arg Arg Pro Pro Arg Ala Gly Arg Pro Leu Cys Gln Ala Asp 
            100                 105                 110         


Pro Gln Pro Gly Lys Ala Ala Arg Arg Ser Leu Glu Pro Asp Pro Ala 
        115                 120                 125             


Gln Thr Gly Pro Arg Pro Ala Arg Ala Ala Gly Met Ser Glu Ala Arg 
    130                 135                 140                 


Lys Gly Pro Asp Glu Ala Glu Glu Ser Gln Tyr Asp Ser Gly Ile Glu 
145                 150                 155                 160 


Ser Leu Arg Ser Leu Arg Ser Leu Pro Glu Ser Thr Ser Ala Pro Ala 
                165                 170                 175     


Ser Gly Pro Ser Asp Gly Ser Pro Gln Pro Cys Thr His Pro Pro Gly 
            180                 185                 190         


Pro Val Lys Glu Pro Gln Glu Lys Glu Asp Ala Asp Gly Glu Arg Ala 
        195                 200                 205             


Asp Ser Thr Tyr Gly Ser Ser Ser Leu Thr Tyr Thr Leu Ser Leu Leu 
    210                 215                 220                 


Gly Gly Pro Glu Ala Glu Asp Pro Ala Pro Arg Leu Pro Leu Pro His 
225                 230                 235                 240 


Val Gly Ala Leu Ser Pro Gln Gln Leu Glu Ala Leu Thr Tyr Ile Ser 
                245                 250                 255     


Glu Asp Gly Asp Thr Leu Val His Leu Ala Val Ile His Glu Ala Pro 
            260                 265                 270         


Ala Val Leu Leu Cys Cys Leu Ala Leu Leu Pro Gln Glu Val Leu Asp 
        275                 280                 285             


Ile Gln Asn Asn Leu Tyr Gln Thr Ala Leu His Leu Ala Val His Leu 
    290                 295                 300                 


Asp Gln Pro Gly Ala Val Arg Ala Leu Val Leu Lys Gly Ala Ser Arg 
305                 310                 315                 320 


Ala Leu Gln Asp Arg His Gly Asp Thr Ala Leu His Val Ala Cys Gln 
                325                 330                 335     


Arg Gln His Leu Ala Cys Ala Arg Cys Leu Leu Glu Gly Arg Pro Glu 
            340                 345                 350         


Pro Gly Arg Gly Thr Ser His Ser Leu Asp Leu Gln Leu Gln Asn Trp 
        355                 360                 365             


Gln Gly Leu Ala Cys Leu His Ile Ala Thr Leu Gln Lys Asn Gln Pro 
    370                 375                 380                 


Leu Met Glu Leu Leu Leu Arg Asn Gly Ala Asp Ile Asp Val Gln Glu 
385                 390                 395                 400 


Gly Thr Ser Gly Lys Thr Ala Leu His Leu Ala Val Glu Thr Gln Glu 
                405                 410                 415     


Arg Gly Leu Val Gln Phe Leu Leu Gln Ala Gly Ala Gln Val Asp Ala 
            420                 425                 430         


Arg Met Leu Asn Gly Cys Thr Pro Leu His Leu Ala Ala Gly Arg Gly 
        435                 440                 445             


Leu Met Gly Ile Ser Ser Thr Leu Cys Lys Ala Gly Ala Asp Ser Leu 
    450                 455                 460                 


Leu Arg Asn Val Glu Asp Glu Thr Pro Gln Asp Leu Thr Glu Glu Ser 
465                 470                 475                 480 


Leu Val Leu Leu Pro Phe Asp Asp Leu Lys Ile Ser Gly Lys Leu Leu 
                485                 490                 495     


Leu Cys Thr Asp 
            500 


<210>  60
<211>  635
<212>  PRT
<213>  Homo Sapiens

<400>  60

Met Ala Ser Ser Gly Met Ala Asp Ser Ala Asn His Leu Pro Phe Phe 
1               5                   10                  15      


Phe Gly Asn Ile Thr Arg Glu Glu Ala Glu Asp Tyr Leu Val Gln Gly 
            20                  25                  30          


Gly Met Ser Asp Gly Leu Tyr Leu Leu Arg Gln Ser Arg Asn Tyr Leu 
        35                  40                  45              


Gly Gly Phe Ala Leu Ser Val Ala His Gly Arg Lys Ala His His Tyr 
    50                  55                  60                  


Thr Ile Glu Arg Glu Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Arg 
65                  70                  75                  80  


Thr His Ala Ser Pro Ala Asp Leu Cys His Tyr His Ser Gln Glu Ser 
                85                  90                  95      


Asp Gly Leu Val Cys Leu Leu Lys Lys Pro Phe Asn Arg Pro Gln Gly 
            100                 105                 110         


Val Gln Pro Lys Thr Gly Pro Phe Glu Asp Leu Lys Glu Asn Leu Ile 
        115                 120                 125             


Arg Glu Tyr Val Lys Gln Thr Trp Asn Leu Gln Gly Gln Ala Leu Glu 
    130                 135                 140                 


Gln Ala Ile Ile Ser Gln Lys Pro Gln Leu Glu Lys Leu Ile Ala Thr 
145                 150                 155                 160 


Thr Ala His Glu Lys Met Pro Trp Phe His Gly Lys Ile Ser Arg Glu 
                165                 170                 175     


Glu Ser Glu Gln Ile Val Leu Ile Gly Ser Lys Thr Asn Gly Lys Phe 
            180                 185                 190         


Leu Ile Arg Ala Arg Asp Asn Asn Gly Ser Tyr Ala Leu Cys Leu Leu 
        195                 200                 205             


His Glu Gly Lys Val Leu His Tyr Arg Ile Asp Lys Asp Lys Thr Gly 
    210                 215                 220                 


Lys Leu Ser Ile Pro Glu Gly Lys Lys Phe Asp Thr Leu Trp Gln Leu 
225                 230                 235                 240 


Val Glu His Tyr Ser Tyr Lys Ala Asp Gly Leu Leu Arg Val Leu Thr 
                245                 250                 255     


Val Pro Cys Gln Lys Ile Gly Thr Gln Gly Asn Val Asn Phe Gly Gly 
            260                 265                 270         


Arg Pro Gln Leu Pro Gly Ser His Pro Ala Thr Trp Ser Ala Gly Gly 
        275                 280                 285             


Ile Ile Ser Arg Ile Lys Ser Tyr Ser Phe Pro Lys Pro Gly His Arg 
    290                 295                 300                 


Lys Ser Ser Pro Ala Gln Gly Asn Arg Gln Glu Ser Thr Val Ser Phe 
305                 310                 315                 320 


Asn Pro Tyr Glu Pro Glu Leu Ala Pro Trp Ala Ala Asp Lys Gly Pro 
                325                 330                 335     


Gln Arg Glu Ala Leu Pro Met Asp Thr Glu Val Tyr Glu Ser Pro Tyr 
            340                 345                 350         


Ala Asp Pro Glu Glu Ile Arg Pro Lys Glu Val Tyr Leu Asp Arg Lys 
        355                 360                 365             


Leu Leu Thr Leu Glu Asp Lys Glu Leu Gly Ser Gly Asn Phe Gly Thr 
    370                 375                 380                 


Val Lys Lys Gly Tyr Tyr Gln Met Lys Lys Val Val Lys Thr Val Ala 
385                 390                 395                 400 


Val Lys Ile Leu Lys Asn Glu Ala Asn Asp Pro Ala Leu Lys Asp Glu 
                405                 410                 415     


Leu Leu Ala Glu Ala Asn Val Met Gln Gln Leu Asp Asn Pro Tyr Ile 
            420                 425                 430         


Val Arg Met Ile Gly Ile Cys Glu Ala Glu Ser Trp Met Leu Val Met 
        435                 440                 445             


Glu Met Ala Glu Leu Gly Pro Leu Asn Lys Tyr Leu Gln Gln Asn Arg 
    450                 455                 460                 


His Val Lys Asp Lys Asn Ile Ile Glu Leu Val His Gln Val Ser Met 
465                 470                 475                 480 


Gly Met Lys Tyr Leu Glu Glu Ser Asn Phe Val His Arg Asp Leu Ala 
                485                 490                 495     


Ala Arg Asn Val Leu Leu Val Thr Gln His Tyr Ala Lys Ile Ser Asp 
            500                 505                 510         


Phe Gly Leu Ser Lys Ala Leu Arg Ala Asp Glu Asn Tyr Tyr Lys Ala 
        515                 520                 525             


Gln Thr His Gly Lys Trp Pro Val Lys Trp Tyr Ala Pro Glu Cys Ile 
    530                 535                 540                 


Asn Tyr Tyr Lys Phe Ser Ser Lys Ser Asp Val Trp Ser Phe Gly Val 
545                 550                 555                 560 


Leu Met Trp Glu Ala Phe Ser Tyr Gly Gln Lys Pro Tyr Arg Gly Met 
                565                 570                 575     


Lys Gly Ser Glu Val Thr Ala Met Leu Glu Lys Gly Glu Arg Met Gly 
            580                 585                 590         


Cys Pro Ala Gly Cys Pro Arg Glu Met Tyr Asp Leu Met Asn Leu Cys 
        595                 600                 605             


Trp Thr Tyr Asp Val Glu Asn Arg Pro Gly Phe Ala Ala Val Glu Leu 
    610                 615                 620                 


Arg Leu Arg Asn Tyr Tyr Tyr Asp Val Val Asn 
625                 630                 635 


<210>  61
<211>  652
<212>  PRT
<213>  Homo Sapiens

<400>  61

Met Ala Glu Ala Pro Gln Val Val Glu Thr Asp Pro Asp Phe Glu Pro 
1               5                   10                  15      


Leu Pro Arg Gln Arg Ser Cys Thr Trp Pro Leu Pro Arg Pro Glu Phe 
            20                  25                  30          


Asn Gln Ser Asn Ser Thr Thr Ser Ser Pro Ala Pro Ser Gly Gly Ala 
        35                  40                  45              


Ala Ala Asn Pro Asp Ala Ala Ala Ser Leu Ala Ser Ala Ser Ala Val 
    50                  55                  60                  


Ser Thr Asp Phe Met Ser Asn Leu Ser Leu Leu Glu Glu Ser Glu Asp 
65                  70                  75                  80  


Phe Ala Arg Ala Pro Gly Cys Val Ala Val Ala Ala Ala Ala Ala Ala 
                85                  90                  95      


Ser Arg Gly Leu Cys Gly Asp Phe Gln Gly Pro Glu Ala Gly Cys Val 
            100                 105                 110         


His Pro Ala Pro Pro Gln Pro Pro Pro Thr Gly Pro Leu Ser Gln Pro 
        115                 120                 125             


Pro Pro Val Pro Pro Ser Ala Ala Ala Ala Ala Gly Pro Leu Ala Gly 
    130                 135                 140                 


Gln Pro Arg Lys Thr Ser Ser Ser Arg Arg Asn Ala Trp Gly Asn Leu 
145                 150                 155                 160 


Ser Tyr Ala Asp Leu Ile Thr Lys Ala Ile Glu Ser Ser Ala Glu Lys 
                165                 170                 175     


Arg Leu Thr Leu Ser Gln Ile Tyr Glu Trp Met Val Lys Ser Val Pro 
            180                 185                 190         


Tyr Phe Lys Asp Lys Gly Asp Ser Asn Ser Ser Ala Gly Trp Lys Asn 
        195                 200                 205             


Ser Ile Arg His Asn Leu Ser Leu His Ser Lys Phe Ile Arg Val Gln 
    210                 215                 220                 


Asn Glu Gly Thr Gly Lys Ser Ser Trp Trp Met Leu Asn Pro Glu Gly 
225                 230                 235                 240 


Gly Lys Ser Gly Lys Ser Pro Arg Arg Arg Ala Ala Ser Met Asp Asn 
                245                 250                 255     


Asn Ser Lys Phe Ala Lys Ser Arg Gly Arg Ala Ala Lys Lys Lys Ala 
            260                 265                 270         


Ser Leu Gln Ser Gly Gln Glu Gly Pro Gly Asp Ser Pro Gly Ser Gln 
        275                 280                 285             


Phe Ser Lys Trp Pro Ala Ser Pro Gly Ser His Ser Asn Asp Asp Phe 
    290                 295                 300                 


Asp Asn Trp Ser Thr Phe Arg Pro Arg Thr Ser Ser Asn Ala Ser Thr 
305                 310                 315                 320 


Ile Ser Gly Arg Leu Ser Pro Ile Met Thr Glu Gln Asp Asp Leu Gly 
                325                 330                 335     


Asp Gly Asp Val His Ser Leu Val Tyr Pro Pro Ser Ala Ala Lys Met 
            340                 345                 350         


Ala Ser Thr Leu Pro Ser Leu Ser Glu Ile Ser Asn Pro Glu Asn Met 
        355                 360                 365             


Glu Asn Leu Leu Asp Asn Leu Asn Leu Leu Ser Ser Pro Thr Ser Leu 
    370                 375                 380                 


Thr Val Ser Thr Gln Ser Ser Pro Gly Ser Met Met Gln Gln Thr Pro 
385                 390                 395                 400 


Cys Tyr Ser Phe Ala Pro Pro Asn Thr Ser Leu Asn Ser Pro Ser Pro 
                405                 410                 415     


Asn Tyr Ser Lys Tyr Thr Tyr Gly Gln Ser Ser Met Ser Pro Leu Pro 
            420                 425                 430         


Gln Met Pro Met Gln Thr Leu Gln Asp Ser Lys Ser Ser Tyr Gly Gly 
        435                 440                 445             


Leu Asn Gln Tyr Asn Cys Ala Pro Gly Leu Leu Lys Glu Leu Leu Thr 
    450                 455                 460                 


Ser Asp Ser Pro Pro His Asn Asp Ile Met Ser Pro Val Asp Pro Gly 
465                 470                 475                 480 


Val Ala Gln Pro Asn Ser Arg Val Leu Gly Gln Asn Val Met Met Gly 
                485                 490                 495     


Pro Asn Ser Val Met Pro Ala Tyr Gly Ser Gln Ala Ser His Asn Lys 
            500                 505                 510         


Met Met Asn Pro Ser Ser His Thr His Pro Gly His Ala Gln Gln Thr 
        515                 520                 525             


Ala Ser Val Asn Gly Arg Thr Leu Pro His Val Val Asn Thr Met Pro 
    530                 535                 540                 


His Thr Ser Ala Met Asn Arg Leu Thr Pro Val Lys Thr Pro Leu Gln 
545                 550                 555                 560 


Val Pro Leu Ser His Pro Met Gln Met Ser Ala Leu Gly Ser Tyr Ser 
                565                 570                 575     


Ser Val Ser Ser Cys Asn Gly Tyr Gly Arg Met Gly Val Leu His Gln 
            580                 585                 590         


Glu Lys Leu Pro Ser Asp Leu Asp Gly Met Phe Ile Glu Arg Leu Asp 
        595                 600                 605             


Cys Asp Met Glu Ser Ile Ile Arg Asn Asp Leu Met Asp Gly Asp Thr 
    610                 615                 620                 


Leu Asp Phe Asn Phe Asp Asn Val Leu Pro Asn Gln Ser Phe Pro His 
625                 630                 635                 640 


Ser Val Lys Thr Thr Thr His Ser Trp Val Ser Gly 
                645                 650         


<210>  62
<211>  226
<212>  PRT
<213>  Homo Sapiens

<400>  62

Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Gly Thr Leu Ile Ile Gln Asn Val 
                85                  90                  95      


Asn Lys Ser His Gly Gly Ile Tyr Val Cys Arg Val Gln Glu Gly Asn 
            100                 105                 110         


Glu Ser Tyr Gln Gln Ser Cys Gly Thr Tyr Leu Arg Val Arg Gln Pro 
        115                 120                 125             


Pro Pro Arg Pro Phe Leu Asp Met Gly Glu Gly Thr Lys Asn Arg Ile 
    130                 135                 140                 


Ile Thr Ala Glu Gly Ile Ile Leu Leu Phe Cys Ala Val Val Pro Gly 
145                 150                 155                 160 


Thr Leu Leu Leu Phe Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu 
                165                 170                 175     


Asp Ala Gly Asp Glu Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn 
            180                 185                 190         


Leu Asp Asp Cys Ser Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly 
        195                 200                 205             


Thr Tyr Gln Asp Val Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu 
    210                 215                 220                 


Lys Pro 
225     


<210>  63
<211>  390
<212>  PRT
<213>  Homo Sapiens

<400>  63

Met Gly Ala Thr Thr Met Asp Gln Lys Ser Leu Trp Ala Gly Val Val 
1               5                   10                  15      


Val Leu Leu Leu Leu Gln Gly Gly Ser Ala Tyr Lys Leu Val Cys Tyr 
            20                  25                  30          


Phe Thr Asn Trp Ser Gln Asp Arg Gln Glu Pro Gly Lys Phe Thr Pro 
        35                  40                  45              


Glu Asn Ile Asp Pro Phe Leu Cys Ser His Leu Ile Tyr Ser Phe Ala 
    50                  55                  60                  


Ser Ile Glu Asn Asn Lys Val Ile Ile Lys Asp Lys Ser Glu Val Met 
65                  70                  75                  80  


Leu Tyr Gln Thr Ile Asn Ser Leu Lys Thr Lys Asn Pro Lys Leu Lys 
                85                  90                  95      


Ile Leu Leu Ser Ile Gly Gly Tyr Leu Phe Gly Ser Lys Gly Phe His 
            100                 105                 110         


Pro Met Val Asp Ser Ser Thr Ser Arg Leu Glu Phe Ile Asn Ser Ile 
        115                 120                 125             


Ile Leu Phe Leu Arg Asn His Asn Phe Asp Gly Leu Asp Val Ser Trp 
    130                 135                 140                 


Ile Tyr Pro Asp Gln Lys Glu Asn Thr His Phe Thr Val Leu Ile His 
145                 150                 155                 160 


Glu Leu Ala Glu Ala Phe Gln Lys Asp Phe Thr Lys Ser Thr Lys Glu 
                165                 170                 175     


Arg Leu Leu Leu Thr Ala Gly Val Ser Ala Gly Arg Gln Met Ile Asp 
            180                 185                 190         


Asn Ser Tyr Gln Val Glu Lys Leu Ala Lys Asp Leu Asp Phe Ile Asn 
        195                 200                 205             


Leu Leu Ser Phe Asp Phe His Gly Ser Trp Glu Lys Pro Leu Ile Thr 
    210                 215                 220                 


Gly His Asn Ser Pro Leu Ser Lys Gly Trp Gln Asp Arg Gly Pro Ser 
225                 230                 235                 240 


Ser Tyr Tyr Asn Val Glu Tyr Ala Val Gly Tyr Trp Ile His Lys Gly 
                245                 250                 255     


Met Pro Ser Glu Lys Val Val Met Gly Ile Pro Thr Tyr Gly His Ser 
            260                 265                 270         


Phe Thr Leu Ala Ser Ala Glu Thr Thr Val Gly Ala Pro Ala Ser Gly 
        275                 280                 285             


Pro Gly Ala Ala Gly Pro Ile Thr Glu Ser Ser Gly Phe Leu Ala Tyr 
    290                 295                 300                 


Tyr Glu Ile Cys Gln Phe Leu Lys Gly Ala Lys Ile Thr Arg Leu Gln 
305                 310                 315                 320 


Asp Gln Gln Val Pro Tyr Ala Val Lys Gly Asn Gln Trp Val Gly Tyr 
                325                 330                 335     


Asp Asp Val Lys Ser Met Glu Thr Lys Val Gln Phe Leu Lys Asn Leu 
            340                 345                 350         


Asn Leu Gly Gly Ala Met Ile Trp Ser Ile Asp Met Asp Asp Phe Thr 
        355                 360                 365             


Gly Lys Ser Cys Asn Gln Gly Pro Tyr Pro Leu Val Gln Ala Val Lys 
    370                 375                 380                 


Arg Ser Leu Gly Ser Leu 
385                 390 


<210>  64
<211>  589
<212>  PRT
<213>  Homo Sapiens

<400>  64

Met Ser Gln Arg Val Arg Arg Asn Gly Ser Pro Thr Pro Ala Gly Ser 
1               5                   10                  15      


Leu Gly Gly Gly Ala Val Ala Thr Ala Gly Gly Pro Gly Ser Arg Leu 
            20                  25                  30          


Gln Pro Met Arg Ala Thr Val Pro Phe Gln Leu Lys Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln His Gly Ser Pro Thr Arg Ser Gly Gly Gly Gly Gly Gly Asn 
    50                  55                  60                  


Asn Asn Gly Gly Cys Cys Gly Gly Ala Ser Gly Pro Ala Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Gly Pro Arg Thr Ala Ser Arg Ser Thr Ser Pro Thr Arg 
                85                  90                  95      


Gly Gly Gly Asn Ala Ala Ala Arg Thr Ser Pro Thr Val Ala Thr Gln 
            100                 105                 110         


Thr Gly Ala Ser Ala Thr Ser Thr Arg Gly Thr Ser Pro Thr Arg Ser 
        115                 120                 125             


Ala Ala Pro Gly Ala Arg Gly Ser Pro Pro Arg Pro Pro Pro Pro Pro 
    130                 135                 140                 


Pro Leu Leu Gly Thr Val Ser Ser Pro Ser Ser Ser Pro Thr His Leu 
145                 150                 155                 160 


Trp Thr Gly Glu Val Ser Ala Ala Pro Pro Pro Ala Arg Val Arg His 
                165                 170                 175     


Arg Arg Arg Ser Pro Glu Gln Ser Arg Ser Ser Pro Glu Lys Arg Ser 
            180                 185                 190         


Pro Ser Ala Pro Val Cys Lys Ala Gly Asp Lys Thr Arg Gln Pro Ser 
        195                 200                 205             


Ser Ser Pro Ser Ser Ile Ile Arg Arg Thr Ser Ser Leu Asp Thr Leu 
    210                 215                 220                 


Ala Ala Pro Tyr Leu Ala Gly His Trp Pro Arg Asp Ser His Gly Gln 
225                 230                 235                 240 


Ala Ala Pro Cys Met Arg Asp Lys Ala Thr Gln Thr Glu Ser Ala Trp 
                245                 250                 255     


Ala Glu Glu Tyr Ser Glu Lys Lys Lys Gly Ser His Lys Arg Ser Ala 
            260                 265                 270         


Ser Trp Gly Ser Thr Asp Gln Leu Lys Glu Ile Ala Lys Leu Arg Gln 
        275                 280                 285             


Gln Leu Gln Arg Ser Lys His Ser Ser Arg His His Arg Asp Lys Glu 
    290                 295                 300                 


Arg Gln Ser Pro Phe His Gly Asn His Ala Ala Ile Asn Gln Cys Gln 
305                 310                 315                 320 


Ala Pro Val Pro Lys Ser Ala Leu Ile Pro Val Ile Pro Ile Thr Lys 
                325                 330                 335     


Ser Thr Gly Ser Arg Phe Arg Asn Ser Val Glu Gly Leu Asn Gln Glu 
            340                 345                 350         


Ile Glu Ile Ile Ile Lys Glu Thr Gly Glu Lys Glu Glu Gln Leu Ile 
        355                 360                 365             


Pro Gln Asp Ile Pro Asp Gly His Arg Ala Pro Pro Pro Leu Val Gln 
    370                 375                 380                 


Arg Ser Ser Ser Thr Arg Ser Ile Asp Thr Gln Thr Pro Gly Gly Ala 
385                 390                 395                 400 


Asp Arg Gly Ser Asn Asn Ser Ser Arg Ser Gln Ser Val Ser Pro Thr 
                405                 410                 415     


Ser Phe Leu Thr Ile Ser Asn Glu Gly Ser Glu Glu Ser Pro Cys Ser 
            420                 425                 430         


Ala Asp Asp Leu Leu Val Asp Pro Arg Asp Lys Glu Asn Gly Asn Asn 
        435                 440                 445             


Ser Pro Leu Pro Lys Tyr Ala Thr Ser Pro Lys Pro Asn Asn Ser Tyr 
    450                 455                 460                 


Met Phe Lys Arg Glu Pro Pro Glu Gly Cys Glu Arg Val Lys Val Phe 
465                 470                 475                 480 


Glu Glu Cys Ser Pro Lys Gln Leu His Glu Ile Pro Ala Phe Tyr Cys 
                485                 490                 495     


Pro Asp Lys Asn Lys Val Asn Phe Ile Pro Lys Ser Gly Ser Ala Phe 
            500                 505                 510         


Cys Leu Val Ser Ile Leu Lys Pro Leu Leu Pro Thr Pro Asp Leu Thr 
        515                 520                 525             


Leu Lys Gly Ser Gly His Ser Leu Thr Val Thr Thr Gly Met Thr Thr 
    530                 535                 540                 


Thr Leu Leu Gln Pro Ile Ala Val Ala Ser Leu Ser Thr Asn Thr Glu 
545                 550                 555                 560 


Gln Asp Arg Val Ser Arg Gly Thr Ser Thr Val Met Pro Ser Ala Ser 
                565                 570                 575     


Leu Leu Pro Pro Pro Glu Pro Ile Glu Glu Ala Glu Gly 
            580                 585                 


<210>  65
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  65

Met Leu Ala Asn Ser Ser Ser Thr Asn Ser Ser Val Leu Pro Cys Pro 
1               5                   10                  15      


Asp Tyr Arg Pro Thr His Arg Leu His Leu Val Val Tyr Ser Leu Val 
            20                  25                  30          


Leu Ala Ala Gly Leu Pro Leu Asn Ala Leu Ala Leu Trp Val Phe Leu 
        35                  40                  45              


Arg Ala Leu Arg Val His Ser Val Val Ser Val Tyr Met Cys Asn Leu 
    50                  55                  60                  


Ala Ala Ser Asp Leu Leu Phe Thr Leu Ser Leu Pro Val Arg Leu Ser 
65                  70                  75                  80  


Tyr Tyr Ala Leu His His Trp Pro Phe Pro Asp Leu Leu Cys Gln Thr 
                85                  90                  95      


Thr Gly Ala Ile Phe Gln Met Asn Met Tyr Gly Ser Cys Ile Phe Leu 
            100                 105                 110         


Met Leu Ile Asn Val Asp Arg Tyr Ala Ala Ile Val His Pro Leu Arg 
        115                 120                 125             


Leu Arg His Leu Arg Arg Pro Arg Val Ala Arg Leu Leu Cys Leu Gly 
    130                 135                 140                 


Val Trp Ala Leu Ile Leu Val Phe Ala Val Pro Ala Ala Arg Val His 
145                 150                 155                 160 


Arg Pro Ser Arg Cys Arg Tyr Arg Asp Leu Glu Val Arg Leu Cys Phe 
                165                 170                 175     


Glu Ser Phe Ser Asp Glu Leu Trp Lys Gly Arg Leu Leu Pro Leu Val 
            180                 185                 190         


Leu Leu Ala Glu Ala Leu Gly Phe Leu Leu Pro Leu Ala Ala Val Val 
        195                 200                 205             


Tyr Ser Ser Gly Arg Val Phe Trp Thr Leu Ala Arg Pro Asp Ala Thr 
    210                 215                 220                 


Gln Ser Gln Arg Arg Arg Lys Thr Val Arg Leu Leu Leu Ala Asn Leu 
225                 230                 235                 240 


Val Ile Phe Leu Leu Cys Phe Val Pro Tyr Asn Ser Thr Leu Ala Val 
                245                 250                 255     


Tyr Gly Leu Leu Arg Ser Lys Leu Val Ala Ala Ser Val Pro Ala Arg 
            260                 265                 270         


Asp Arg Val Arg Gly Val Leu Met Val Met Val Leu Leu Ala Gly Ala 
        275                 280                 285             


Asn Cys Val Leu Asp Pro Leu Val Tyr Tyr Phe Ser Ala Glu Gly Phe 
    290                 295                 300                 


Arg Asn Thr Leu Arg Gly Leu Gly Thr Pro His Arg Ala Arg Thr Ser 
305                 310                 315                 320 


Ala Thr Asn Gly Thr Arg Ala Ala Leu Ala Gln Ser Glu Arg Ser Ala 
                325                 330                 335     


Val Thr Thr Asp Ala Thr Arg Pro Asp Ala Ala Ser Gln Gly Leu Leu 
            340                 345                 350         


Arg Pro Ser Asp Ser His Ser Leu Ser Ser Phe Thr Gln Cys Pro Gln 
        355                 360                 365             


Asp Ser Ala Leu 
    370         


<210>  66
<211>  943
<212>  PRT
<213>  Homo Sapiens

<400>  66

Met Pro Ser Thr Ser Phe Pro Val Pro Ser Lys Phe Pro Leu Gly Pro 
1               5                   10                  15      


Ala Ala Ala Val Phe Gly Arg Gly Glu Thr Leu Gly Pro Ala Pro Arg 
            20                  25                  30          


Ala Gly Gly Thr Met Lys Ser Ala Glu Glu Glu His Tyr Gly Tyr Ala 
        35                  40                  45              


Ser Ser Asn Val Ser Pro Ala Leu Pro Leu Pro Thr Ala His Ser Thr 
    50                  55                  60                  


Leu Pro Ala Pro Cys His Asn Leu Gln Thr Ser Thr Pro Gly Ile Ile 
65                  70                  75                  80  


Pro Pro Ala Asp His Pro Ser Gly Tyr Gly Ala Ala Leu Asp Gly Gly 
                85                  90                  95      


Pro Ala Gly Tyr Phe Leu Ser Ser Gly His Thr Arg Pro Asp Gly Ala 
            100                 105                 110         


Pro Ala Leu Glu Ser Pro Arg Ile Glu Ile Thr Ser Cys Leu Gly Leu 
        115                 120                 125             


Tyr His Asn Asn Asn Gln Phe Phe His Asp Val Glu Val Glu Asp Val 
    130                 135                 140                 


Leu Pro Ser Ser Lys Arg Ser Pro Ser Thr Ala Thr Leu Ser Leu Pro 
145                 150                 155                 160 


Ser Leu Glu Ala Tyr Arg Asp Pro Ser Cys Leu Ser Pro Ala Ser Ser 
                165                 170                 175     


Leu Ser Ser Arg Ser Cys Asn Ser Glu Ala Ser Ser Tyr Glu Ser Asn 
            180                 185                 190         


Tyr Ser Tyr Pro Tyr Ala Ser Pro Gln Thr Ser Pro Trp Gln Ser Pro 
        195                 200                 205             


Cys Val Ser Pro Lys Thr Thr Asp Pro Glu Glu Gly Phe Pro Arg Gly 
    210                 215                 220                 


Leu Gly Ala Cys Thr Leu Leu Gly Ser Pro Arg His Ser Pro Ser Thr 
225                 230                 235                 240 


Ser Pro Arg Ala Ser Val Thr Glu Glu Ser Trp Leu Gly Ala Arg Ser 
                245                 250                 255     


Ser Arg Pro Ala Ser Pro Cys Asn Lys Arg Lys Tyr Ser Leu Asn Gly 
            260                 265                 270         


Arg Gln Pro Pro Tyr Ser Pro His His Ser Pro Thr Pro Ser Pro His 
        275                 280                 285             


Gly Ser Pro Arg Val Ser Val Thr Asp Asp Ser Trp Leu Gly Asn Thr 
    290                 295                 300                 


Thr Gln Tyr Thr Ser Ser Ala Ile Val Ala Ala Ile Asn Ala Leu Thr 
305                 310                 315                 320 


Thr Asp Ser Ser Leu Asp Leu Gly Asp Gly Val Pro Val Lys Ser Arg 
                325                 330                 335     


Lys Thr Thr Leu Glu Gln Pro Pro Ser Val Ala Leu Lys Val Glu Pro 
            340                 345                 350         


Val Gly Glu Asp Leu Gly Ser Pro Pro Pro Pro Ala Asp Phe Ala Pro 
        355                 360                 365             


Glu Asp Tyr Ser Ser Phe Gln His Ile Arg Lys Gly Gly Phe Cys Asp 
    370                 375                 380                 


Gln Tyr Leu Ala Val Pro Gln His Pro Tyr Gln Trp Ala Lys Pro Lys 
385                 390                 395                 400 


Pro Leu Ser Pro Thr Ser Tyr Met Ser Pro Thr Leu Pro Ala Leu Asp 
                405                 410                 415     


Trp Gln Leu Pro Ser His Ser Gly Pro Tyr Glu Leu Arg Ile Glu Val 
            420                 425                 430         


Gln Pro Lys Ser His His Arg Ala His Tyr Glu Thr Glu Gly Ser Arg 
        435                 440                 445             


Gly Ala Val Lys Ala Ser Ala Gly Gly His Pro Ile Val Gln Leu His 
    450                 455                 460                 


Gly Tyr Leu Glu Asn Glu Pro Leu Met Leu Gln Leu Phe Ile Gly Thr 
465                 470                 475                 480 


Ala Asp Asp Arg Leu Leu Arg Pro His Ala Phe Tyr Gln Val His Arg 
                485                 490                 495     


Ile Thr Gly Lys Thr Val Ser Thr Thr Ser His Glu Ala Ile Leu Ser 
            500                 505                 510         


Asn Thr Lys Val Leu Glu Ile Pro Leu Leu Pro Glu Asn Ser Met Arg 
        515                 520                 525             


Ala Val Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg Asn Ser Asp Ile 
    530                 535                 540                 


Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys Asn Thr Arg Val 
545                 550                 555                 560 


Arg Leu Val Phe Arg Val His Val Pro Gln Pro Ser Gly Arg Thr Leu 
                565                 570                 575     


Ser Leu Gln Val Ala Ser Asn Pro Ile Glu Cys Ser Gln Arg Ser Ala 
            580                 585                 590         


Gln Glu Leu Pro Leu Val Glu Lys Gln Ser Thr Asp Ser Tyr Pro Val 
        595                 600                 605             


Val Gly Gly Lys Lys Met Val Leu Ser Gly His Asn Phe Leu Gln Asp 
    610                 615                 620                 


Ser Lys Val Ile Phe Val Glu Lys Ala Pro Asp Gly His His Val Trp 
625                 630                 635                 640 


Glu Met Glu Ala Lys Thr Asp Arg Asp Leu Cys Lys Pro Asn Ser Leu 
                645                 650                 655     


Val Val Glu Ile Pro Pro Phe Arg Asn Gln Arg Ile Thr Ser Pro Val 
            660                 665                 670         


His Val Ser Phe Tyr Val Cys Asn Gly Lys Arg Lys Arg Ser Gln Tyr 
        675                 680                 685             


Gln Arg Phe Thr Tyr Leu Pro Ala Asn Val Pro Ile Ile Lys Thr Glu 
    690                 695                 700                 


Pro Thr Asp Asp Tyr Glu Pro Ala Pro Thr Cys Gly Pro Val Ser Gln 
705                 710                 715                 720 


Gly Leu Ser Pro Leu Pro Arg Pro Tyr Tyr Ser Gln Gln Leu Ala Met 
                725                 730                 735     


Pro Pro Asp Pro Ser Ser Cys Leu Val Ala Gly Phe Pro Pro Cys Pro 
            740                 745                 750         


Gln Arg Ser Thr Leu Met Pro Ala Ala Pro Gly Val Ser Pro Lys Leu 
        755                 760                 765             


His Asp Leu Ser Pro Ala Ala Tyr Thr Lys Gly Val Ala Ser Pro Gly 
    770                 775                 780                 


His Cys His Leu Gly Leu Pro Gln Pro Ala Gly Glu Ala Pro Ala Val 
785                 790                 795                 800 


Gln Asp Val Pro Arg Pro Val Ala Thr His Pro Gly Ser Pro Gly Gln 
                805                 810                 815     


Pro Pro Pro Ala Leu Leu Pro Gln Gln Val Ser Ala Pro Pro Ser Ser 
            820                 825                 830         


Ser Cys Pro Pro Gly Leu Glu His Ser Leu Cys Pro Ser Ser Pro Ser 
        835                 840                 845             


Pro Pro Leu Pro Pro Ala Thr Gln Glu Pro Thr Cys Leu Gln Pro Cys 
    850                 855                 860                 


Ser Pro Ala Cys Pro Pro Ala Thr Gly Arg Pro Gln His Leu Pro Ser 
865                 870                 875                 880 


Thr Val Arg Arg Asp Glu Ser Pro Thr Ala Gly Pro Arg Leu Leu Pro 
                885                 890                 895     


Glu Val His Glu Asp Gly Ser Pro Asn Leu Ala Pro Ile Pro Val Thr 
            900                 905                 910         


Val Lys Arg Glu Pro Glu Glu Leu Asp Gln Leu Tyr Leu Asp Asp Val 
        915                 920                 925             


Asn Glu Ile Ile Arg Asn Asp Leu Ser Ser Thr Ser Thr His Ser 
    930                 935                 940             


<210>  67

<400>  67
000

<210>  68
<211>  239
<212>  PRT
<213>  Homo Sapiens

<400>  68

Met Leu Leu Gln Pro Ala Pro Cys Ala Pro Ser Ala Gly Phe Pro Arg 
1               5                   10                  15      


Pro Leu Ala Ala Pro Gly Ala Met His Gly Ser Gln Lys Asp Thr Thr 
            20                  25                  30          


Phe Thr Lys Ile Phe Val Gly Gly Leu Pro Tyr His Thr Thr Asp Ala 
        35                  40                  45              


Ser Leu Arg Lys Tyr Phe Glu Gly Phe Gly Asp Ile Glu Glu Ala Val 
    50                  55                  60                  


Val Ile Thr Asp Arg Gln Thr Gly Lys Ser Arg Gly Tyr Gly Phe Val 
65                  70                  75                  80  


Thr Met Ala Asp Arg Ala Ala Ala Glu Arg Ala Cys Lys Asp Pro Asn 
                85                  90                  95      


Pro Ile Ile Asp Gly Arg Lys Ala Asn Val Asn Leu Ala Tyr Leu Gly 
            100                 105                 110         


Ala Lys Pro Arg Ser Leu Gln Thr Gly Phe Ala Ile Gly Val Gln Gln 
        115                 120                 125             


Leu His Pro Thr Leu Ile Gln Arg Thr Tyr Gly Leu Thr Pro His Tyr 
    130                 135                 140                 


Ile Tyr Pro Pro Ala Ile Val Gln Pro Ser Val Val Ile Pro Ala Ala 
145                 150                 155                 160 


Pro Val Pro Ser Leu Ser Ser Pro Tyr Ile Glu Tyr Thr Pro Ala Ser 
                165                 170                 175     


Pro Ala Tyr Ala Gln Tyr Pro Pro Ala Thr Tyr Asp Gln Tyr Pro Tyr 
            180                 185                 190         


Ala Ala Ser Pro Ala Thr Ala Ala Ser Phe Val Gly Tyr Ser Tyr Pro 
        195                 200                 205             


Ala Ala Val Pro Gln Ala Leu Ser Ala Ala Ala Pro Ala Gly Thr Thr 
    210                 215                 220                 


Phe Val Gln Tyr Gln Ala Pro Gln Leu Gln Pro Asp Arg Met Gln 
225                 230                 235                 


<210>  69
<211>  441
<212>  PRT
<213>  Homo Sapiens

<400>  69

Met Ser Leu Arg Gln Arg Leu Ala Gln Leu Val Gly Arg Leu Gln Asp 
1               5                   10                  15      


Pro Gln Lys Val Ala Arg Phe Gln Arg Leu Cys Gly Val Glu Ala Pro 
            20                  25                  30          


Pro Arg Arg Ser Ala Asp Arg Arg Glu Asp Glu Lys Ala Glu Ala Pro 
        35                  40                  45              


Leu Ala Gly Asp Pro Arg Leu Arg Gly Arg Gln Pro Gly Ala Pro Gly 
    50                  55                  60                  


Gly Pro Gln Pro Pro Gly Ser Asp Arg Asn Gln Cys Pro Ala Lys Pro 
65                  70                  75                  80  


Asp Gly Gly Gly Ala Pro Asn Gly Val Arg Asn Gly Leu Ala Ala Glu 
                85                  90                  95      


Leu Gly Pro Ala Ser Pro Arg Arg Ala Gly Ala Leu Arg Arg Asn Ser 
            100                 105                 110         


Leu Thr Gly Glu Glu Gly Gln Leu Ala Arg Val Ser Asn Trp Pro Leu 
        115                 120                 125             


Tyr Cys Leu Phe Cys Phe Gly Thr Glu Leu Gly Asn Glu Leu Phe Tyr 
    130                 135                 140                 


Ile Leu Phe Phe Pro Phe Trp Ile Trp Asn Leu Asp Pro Leu Val Gly 
145                 150                 155                 160 


Arg Arg Leu Val Val Ile Trp Val Leu Val Met Tyr Leu Gly Gln Cys 
                165                 170                 175     


Thr Lys Asp Ile Ile Arg Trp Pro Arg Pro Ala Ser Pro Pro Val Val 
            180                 185                 190         


Lys Leu Glu Val Phe Tyr Asn Ser Glu Tyr Ser Met Pro Ser Thr His 
        195                 200                 205             


Ala Met Ser Gly Thr Ala Ile Pro Ile Ser Met Val Leu Leu Thr Tyr 
    210                 215                 220                 


Gly Arg Trp Gln Tyr Pro Leu Ile Tyr Gly Leu Ile Leu Ile Pro Cys 
225                 230                 235                 240 


Trp Cys Ser Leu Val Cys Leu Ser Arg Ile Tyr Met Gly Met His Ser 
                245                 250                 255     


Ile Leu Asp Ile Ile Ala Gly Phe Leu Tyr Thr Ile Leu Ile Leu Ala 
            260                 265                 270         


Val Phe Tyr Pro Phe Val Asp Leu Ile Asp Asn Phe Asn Gln Thr His 
        275                 280                 285             


Lys Tyr Ala Pro Phe Ile Ile Ile Gly Leu His Leu Ala Leu Gly Ile 
    290                 295                 300                 


Phe Ser Phe Thr Leu Asp Thr Trp Ser Thr Ser Arg Gly Asp Thr Ala 
305                 310                 315                 320 


Glu Ile Leu Gly Ser Gly Ala Gly Ile Ala Cys Gly Ser His Val Thr 
                325                 330                 335     


Tyr Asn Met Gly Leu Val Leu Asp Pro Ser Leu Asp Thr Leu Pro Leu 
            340                 345                 350         


Ala Gly Pro Pro Ile Thr Val Thr Leu Phe Gly Lys Ala Ile Leu Arg 
        355                 360                 365             


Ile Leu Ile Gly Met Val Phe Val Leu Ile Ile Arg Asp Val Met Lys 
    370                 375                 380                 


Lys Ile Thr Ile Pro Leu Ala Cys Lys Ile Phe Asn Ile Pro Cys Asp 
385                 390                 395                 400 


Asp Ile Arg Lys Ala Arg Gln His Met Glu Val Glu Leu Pro Tyr Arg 
                405                 410                 415     


Tyr Ile Thr Tyr Gly Met Val Gly Phe Ser Ile Thr Phe Phe Val Pro 
            420                 425                 430         


Tyr Ile Phe Phe Phe Ile Gly Ile Ser 
        435                 440     


<210>  70
<211>  736
<212>  PRT
<213>  Homo Sapiens

<400>  70

Met Lys Thr Glu Ala Gln Pro Ser Thr Ser Leu Leu Ala Asn Thr Ser 
1               5                   10                  15      


Trp Thr Gly Thr Val Ile Ser Asp Ser Val Pro Gly Ser Gln Thr Trp 
            20                  25                  30          


Glu Asp Lys Gly Ser Leu Thr Arg Ser Ala Thr Ser Trp Thr Ser Glu 
        35                  40                  45              


Ala Gln Val Ser Ala Ala Arg Val Ala Glu Ala Gln Ala Arg Thr Ser 
    50                  55                  60                  


Gln Pro Lys Gln Ile Ser Val Leu Glu Ala Leu Thr Ala Ser Ala Leu 
65                  70                  75                  80  


Asn Gln Lys Pro Thr His Glu Lys Val Gln Met Thr Glu Lys Lys Glu 
                85                  90                  95      


Ser Glu Val Leu Leu Ala Arg Pro Phe Trp Ser Ser Lys Thr Glu Tyr 
            100                 105                 110         


Ile Leu Ala Gln Val Gly Phe Ser Met Lys Pro Ser Cys Leu Trp Arg 
        115                 120                 125             


Phe Ala Tyr Leu Trp Leu Asn Ser Gly Gly Cys Ser Phe Ala Ala Ile 
    130                 135                 140                 


Tyr Ile Phe Met Leu Phe Leu Val Gly Val Pro Leu Leu Phe Leu Glu 
145                 150                 155                 160 


Met Ala Ala Gly Gln Ser Met Arg Gln Gly Gly Met Gly Val Trp Lys 
                165                 170                 175     


Ile Ile Ala Pro Trp Ile Gly Gly Val Gly Tyr Ser Ser Phe Met Val 
            180                 185                 190         


Cys Phe Ile Leu Gly Leu Tyr Phe Asn Val Val Asn Ser Trp Ile Ile 
        195                 200                 205             


Phe Tyr Met Ser Gln Ser Phe Gln Phe Pro Val Pro Trp Glu Lys Cys 
    210                 215                 220                 


Pro Leu Thr Met Asn Ser Ser Gly Phe Asp Pro Glu Cys Glu Arg Thr 
225                 230                 235                 240 


Thr Pro Ser Ile Tyr Phe Trp Tyr Gln Gln Ala Leu Lys Ala Ser Asp 
                245                 250                 255     


Arg Ile Glu Asp Gly Gly Ser Pro Val Tyr Ser Leu Val Leu Pro Phe 
            260                 265                 270         


Phe Leu Cys Trp Cys Leu Val Gly Ala Phe Met Ile Asn Gly Leu Lys 
        275                 280                 285             


Ser Thr Gly Lys Val Ile Tyr Val Leu Val Leu Leu Pro Cys Phe Ile 
    290                 295                 300                 


Ile Val Gly Phe Phe Ile Arg Thr Leu Leu Leu Glu Gly Ala Lys Phe 
305                 310                 315                 320 


Gly Leu Gln Gln Leu Val Val Ala Lys Ile Ser Asp Val Tyr Asn Met 
                325                 330                 335     


Ser Val Trp Ser Leu Ala Gly Gly Gln Val Leu Ser Asn Thr Gly Ile 
            340                 345                 350         


Gly Leu Gly Ser Val Ala Ser Leu Ala Ser Tyr Met Pro Gln Ser Asn 
        355                 360                 365             


Asn Cys Leu Ser Asp Ala Phe Leu Val Ser Val Ile Asn Leu Leu Thr 
    370                 375                 380                 


Leu Leu Val Phe Thr Ser Phe Asn Phe Cys Val Leu Gly Phe Trp Ala 
385                 390                 395                 400 


Thr Val Ile Thr His Arg Cys Cys Glu Arg Asn Ala Glu Ile Leu Leu 
                405                 410                 415     


Lys Leu Ile Asn Leu Gly Lys Leu Pro Pro Asp Ala Lys Pro Pro Val 
            420                 425                 430         


Asn Leu Leu Tyr Asn Pro Thr Ser Ile Tyr Asn Ala Trp Leu Ser Gly 
        435                 440                 445             


Leu Pro Gln His Ile Lys Ser Met Val Leu Arg Glu Val Thr Glu Cys 
    450                 455                 460                 


Asn Ile Glu Thr Gln Phe Leu Lys Ala Ser Glu Gly Pro Lys Phe Ala 
465                 470                 475                 480 


Phe Leu Ser Phe Val Glu Ala Met Ser Phe Leu Pro Pro Ser Val Phe 
                485                 490                 495     


Trp Ser Phe Ile Phe Phe Leu Met Leu Leu Ala Met Gly Leu Ser Ser 
            500                 505                 510         


Ala Ile Gly Ile Met Gln Gly Ile Ile Thr Pro Leu Gln Asp Thr Phe 
        515                 520                 525             


Ser Phe Phe Arg Lys His Thr Lys Leu Leu Ile Val Gly Val Phe Leu 
    530                 535                 540                 


Leu Met Phe Val Cys Gly Leu Phe Phe Thr Arg Pro Ser Gly Ser Tyr 
545                 550                 555                 560 


Phe Ile Arg Leu Leu Ser Asp Tyr Trp Ile Val Phe Pro Ile Ile Val 
                565                 570                 575     


Val Val Val Phe Glu Thr Met Ala Val Ser Trp Ala Tyr Gly Ala Arg 
            580                 585                 590         


Arg Phe Leu Ala Asp Leu Thr Ile Leu Leu Gly His Pro Ile Ser Pro 
        595                 600                 605             


Ile Phe Gly Trp Leu Trp Pro His Leu Cys Pro Val Val Leu Leu Ile 
    610                 615                 620                 


Ile Phe Val Thr Met Met Val His Leu Cys Met Lys Pro Ile Thr Tyr 
625                 630                 635                 640 


Met Ser Trp Asp Ser Ser Thr Ser Lys Glu Val Leu Arg Pro Tyr Pro 
                645                 650                 655     


Pro Trp Ala Leu Leu Leu Met Ile Thr Leu Phe Ala Ile Val Ile Leu 
            660                 665                 670         


Pro Ile Pro Ala Tyr Phe Val Tyr Cys Arg Ile His Arg Ile Pro Phe 
        675                 680                 685             


Arg Pro Lys Ser Gly Asp Gly Pro Met Thr Ala Ser Thr Ser Leu Pro 
    690                 695                 700                 


Leu Ser His Gln Leu Thr Pro Ser Lys Glu Val Gln Lys Glu Glu Ile 
705                 710                 715                 720 


Leu Gln Val Asp Glu Thr Lys Tyr Pro Ser Thr Cys Asn Val Thr Ser 
                725                 730                 735     


