                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  Novel acylating agents

<130>  160032WO01

<150>  EP16197464.7
<151>  2016-11-07

<150>  EP17181621.8
<151>  2017-07-17

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  31
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  human GLP-1(7-37)

<400>  1

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  2
<211>  36
<212>  PRT
<213>  Artificial

<220>
<223>  GLP-1 analogue


<220>
<221>  PEPTIDE
<222>  (1)..(36)
<223>  GLP-1 analogue

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  2

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Lys 
            20                  25                  30          


Gly Gly Ser Lys 
        35      


<210>  3
<211>  34
<212>  PRT
<213>  Artificial

<220>
<223>  GLP-1 analogue


<220>
<221>  PEPTIDE
<222>  (1)..(34)

<400>  3

Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu Gln Ala 
1               5                   10                  15      


Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Lys Gly Gly 
            20                  25                  30          


Ser Lys 
        


<210>  4
<211>  36
<212>  PRT
<213>  Artificial

<220>
<223>  GLP-1 analogue


<220>
<221>  PEPTIDE
<222>  (1)..(36)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  4

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Lys 
            20                  25                  30          


Ser Pro Glu Lys 
        35      


<210>  5
<211>  34
<212>  PRT
<213>  Artificial

<220>
<223>  GLP-1 analogue


<220>
<221>  PEPTIDE
<222>  (1)..(34)

<400>  5

Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu Gln Ala 
1               5                   10                  15      


Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Lys Ser Pro 
            20                  25                  30          


Glu Lys 
        


<210>  6
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  GLP-1 analogue


<220>
<221>  PEPTIDE
<222>  (1)..(31)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  6

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  7
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  GLP-1 analogue


<220>
<221>  PEPTIDE
<222>  (1)..(29)

<400>  7

Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala 
1               5                   10                  15      


Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  


<210>  8
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  A-chain of insulin analogue


<220>
<221>  PEPTIDE
<222>  (1)..(21)
<223>  A-chain of A14E, B25H, desB27, desB30 human insulin

<400>  8

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  9
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  B-chain of insulin analogue


<220>
<221>  PEPTIDE
<222>  (1)..(28)
<223>  B-chain of A14E, B25H, desB27, desB30 human insulin

<400>  9

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Lys Tyr Pro Lys 
            20                  25              


<210>  10
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Insulin analogue A chain


<220>
<221>  PEPTIDE
<222>  (1)..(21)
<223>  A-chain of A14E, B25H, desB30 human insulin

<400>  10

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  11
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  Insulin analogue B chain


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  B-chain of A14E, B25H, B29K, desB30 human insulin

<400>  11

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe His Tyr Thr Pro Lys 
            20                  25                  


<210>  12
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  GLP-1 analogue


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  12

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Lys Gly Glu 
            20                  25                  30          


Gly 
    


<210>  13
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  GLP-1 analogue


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  13

Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu Gln Ala 
1               5                   10                  15      


Ala Arg Lys Phe Ile Glu Trp Leu Val Arg Gly Arg Lys Glu Gly 
            20                  25                  30      


<210>  14
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  GLP-1 analogue


<220>
<221>  PEPTIDE
<222>  (1)..(28)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  14

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Lys Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Lys Phe Ile Glu Trp Leu Val Gly 
            20                  25              


<210>  15
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  GLP-1 analogue


<220>
<221>  PEPTIDE
<222>  (1)..(26)

<400>  15

Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Lys Glu Glu Gln Ala 
1               5                   10                  15      


Ala Arg Lys Phe Ile Glu Trp Leu Val Gly 
            20                  25      


<210>  16
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  GLP-1 analogue


<220>
<221>  PEPTIDE
<222>  (1)..(31)

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aib

<400>  16

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys 
            20                  25                  30      


<210>  17
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  GLP-1 analogue


<220>
<221>  PEPTIDE
<222>  (1)..(29)

<400>  17

Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly Gln Ala 
1               5                   10                  15      


Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  


<210>  18
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  GLP-1 analogue


<220>
<221>  PEPTIDE
<222>  (1)..(31)

<220>
<221>  MOD_RES
<222>  (1)..(31)
<223>  Aib

<400>  18

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys 
            20                  25                  30      


<210>  19
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  GLP-1 analogue


<220>
<221>  PEPTIDE
<222>  (1)..(29)

<400>  19

Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu Gln Ala 
1               5                   10                  15      


Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Lys 
            20                  25                  


<210>  20
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  A-chain of insulin analogue


<220>
<221>  PEPTIDE
<222>  (1)..(21)
<223>  A-chain of A14E, B16H, B25H, desB30 human insulin

<400>  20

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Glu Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  21
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  B-chain of insulin analogue


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  B-chain of A14E, B16E, B25H, desB30 human insulin

<400>  21

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu His 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe His Tyr Thr Pro Lys 
            20                  25                  


