                         SEQUENCE LISTING

<110>  PsiOxus Therapeutics Limited
 
<120>  Oncolytic Adenovirus Encoding Transgenes

<130>  P000201_WO

<150>  GB1618572.0
<151>  2016-11-03

<160>  104   

<170>  PatentIn version 3.5

<210>  1
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD80 Amino acid sequence

<400>  1

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly 
                245                 250                 255     


Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg 
            260                 265                 270         


Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
        275                 280                 285             


<210>  2
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Membrane anchored form of the anti-human CD3 single chain Fv

<400>  2

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser 
145                 150                 155                 160 


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
                165                 170                 175     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser 
            180                 185                 190         


Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser 
        195                 200                 205             


Gly Val Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
    210                 215                 220                 


Leu Thr Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
225                 230                 235                 240 


Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu 
                245                 250                 255     


Glu Ile Asn Arg Gly Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            260                 265                 270         


Asn Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser 
        275                 280                 285             


Leu Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val 
    290                 295                 300                 


Leu Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys 
305                 310                 315                 320 


Pro Arg 
        


<210>  3
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Macrophage Inflammatory protein 1alpha amino acid sequence 
       (LD78 beta isoform)

<400>  3

Met Gln Val Ser Thr Ala Ala Leu Ala Val Leu Leu Cys Thr Met Ala 
1               5                   10                  15      


Leu Cys Asn Gln Val Leu Ser Ala Pro Leu Ala Ala Asp Thr Pro Thr 
            20                  25                  30          


Ala Cys Cys Phe Ser Tyr Thr Ser Arg Gln Ile Pro Gln Asn Phe Ile 
        35                  40                  45              


Ala Asp Tyr Phe Glu Thr Ser Ser Gln Cys Ser Lys Pro Ser Val Ile 
    50                  55                  60                  


Phe Leu Thr Lys Arg Gly Arg Gln Val Cys Ala Asp Pro Ser Glu Glu 
65                  70                  75                  80  


Trp Val Gln Lys Tyr Val Ser Asp Leu Glu Leu Ser Ala 
                85                  90              


<210>  4
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  High efficiency self-cleavable P2A peptide sequence

<400>  4

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  5
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  High efficiency self-cleavable T2A peptide sequence

<400>  5

Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210>  6
<211>  192
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Poly-adenylation sequence (SV40 late polyA sequence)

<400>  6
cagacatgat aagatacatt gatgagtttg gacaaaccac aactagaatg cagtgaaaaa       60

aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ataagctgca      120

ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag ggggaggtgt      180

gggaggtttt tt                                                          192


<210>  7
<211>  34861
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NG-500 genome sequence

<400>  7
tctatctata taatatacct tatagatgga atggtgccaa tatgtaaatg aggtgatttt       60

aaaaagtgtg gatcgtgtgg tgattggctg tggggttaac ggctaaaagg ggcggtgcga      120

ccgtgggaaa atgacgtttt gtgggggtgg agtttttttg caagttgtcg cgggaaatgt      180

gacgcataaa aaggcttttt tctcacggaa ctacttagtt ttcccacggt atttaacagg      240

aaatgaggta gttttgaccg gatgcaagtg aaaattgttg attttcgcgc gaaaactgaa      300

tgaggaagtg tttttctgaa taatgtggta tttatggcag ggtggagtat ttgttcaggg      360

ccaggtagac tttgacccat tacgtggagg tttcgattac cgtgtttttt acctgaattt      420

ccgcgtaccg tgtcaaagtc ttctgttttt acgtaggtgt cagctgatcg ctagggtatt      480

tatacctcag ggtttgtgtc aagaggccac tcttgagtgc cagcgagaag agttttctcc      540

tctgcgccgg cagtttaata ataaaaaaat gagagatttg cgatttctgc ctcaggaaat      600

aatctctgct gagactggaa atgaaatatt ggagcttgtg gtgcacgccc tgatgggaga      660

cgatccggag ccacctgtgc agctttttga gcctcctacg cttcaggaac tgtatgattt      720

agaggtagag ggatcggagg attctaatga ggaagctgta aatggctttt ttaccgattc      780

tatgctttta gctgctaatg aagggttaga attagatccg cctttggaca cttttgatac      840

tccaggggta attgtggaaa gcggtacagg tgtaagaaaa ttacctgatt tgagttccgt      900

ggactgtgat ttgcactgct atgaagacgg gtttcctccg agtgatgagg aggaccatga      960

aaaggagcag tccatgcaga ctgcagcggg tgagggagtg aaggctgcca atgttggttt     1020

tcagttggat tgcccggagc ttcctggaca tggctgtaag tcttgtgaat ttcacaggaa     1080

aaatactgga gtaaaggaac tgttatgttc gctttgttat atgagaacgc actgccactt     1140

tatttacagt aagtgtgttt aagttaaaat ttaaaggaat atgctgtttt tcacatgtat     1200

attgagtgtg agttttgtgc ttcttattat aggtcctgtg tctgatgctg atgaatcacc     1260

atctcctgat tctactacct cacctcctga gattcaagca cctgttcctg tggacgtgcg     1320

caagcccatt cctgtgaagc ttaagcctgg gaaacgtcca gcagtggaaa aacttgagga     1380

cttgttacag ggtggggacg gacctttgga cttgagtaca cggaaacgtc caagacaata     1440

agtgttccat atccgtgttt acttaaggtg acgtcaatat ttgtgtgaca gtgcaatgta     1500

ataaaaatat gttaactgtt cactggtttt tattgctttt tgggcgggga ctcaggtata     1560

taagtagaag cagacctgtg tggttagctc ataggagctg gctttcatcc atggaggttt     1620

gggccatttt ggaagacctt aggaagacta ggcaactgtt agagaacgct tcggacggag     1680

tctccggttt ttggagattc tggttcgcta gtgaattagc tagggtagtt tttaggataa     1740

aacaggacta taaacaagaa tttgaaaagt tgttggtaga ttgcccagga ctttttgaag     1800

ctcttaattt gggccatcag gttcacttta aagaaaaagt tttatcagtt ttagactttt     1860

caaccccagg tagaactgct gctgctgtgg cttttcttac ttttatatta gataaatgga     1920

tcccgcagac tcatttcagc aggggatacg ttttggattt catagccaca gcattgtgga     1980

gaacatggaa ggttcgcaag atgaggacaa tcttaggtta ctggccagtg cagcctttgg     2040

gtgtagcggg aatcctgagg catccaccgg tcatgccagc ggttctggag gaggaacagc     2100

aagaggacaa cccgagagcc ggcctggacc ctccagtgga ggaggcggag tagctgactt     2160

gtctcctgaa ctgcaacggg tgcttactgg atctacgtcc actggacggg ataggggcgt     2220

taagagggag agggcatcta gtggtactga tgctagatct gagttggctt taagtttaat     2280

gagtcgcaga cgtcctgaaa ccatttggtg gcatgaggtt cagaaagagg gaagggatga     2340

agtttctgta ttgcaggaga aatattcact ggaacaggtg aaaacatgtt ggttggagcc     2400

tgaggatgat tgggaggtgg ccattaaaaa ttatgccaag atagctttga ggcctgataa     2460

acagtataag attactagac ggattaatat ccggaatgct tgttacatat ctggaaatgg     2520

ggctgaggtg gtaatagata ctcaagacaa ggcagttatt agatgctgca tgatggatat     2580

gtggcctggg gtagtcggta tggaagcagt aacttttgta aatgttaagt ttaggggaga     2640

tggttataat ggaatagtgt ttatggccaa taccaaactt atattgcatg gttgtagctt     2700

ttttggtttc aacaatacct gtgtagatgc ctggggacag gttagtgtac ggggatgtag     2760

tttctatgcg tgttggattg ccacagctgg cagaaccaag agtcaattgt ctctgaagaa     2820

atgcatattt caaagatgta acctgggcat tctgaatgaa ggcgaagcaa gggtccgcca     2880

ctgcgcttct acagatactg gatgttttat tttgattaag ggaaatgcca gcgtaaagca     2940

taacatgatt tgcggtgctt ccgatgagag gccttatcaa atgctcactt gtgctggtgg     3000

gcattgtaat atgctggcta ctgtgcatat tgtttcccat caacgcaaaa aatggcctgt     3060

ttttgatcac aatgtgatga cgaagtgtac catgcatgca ggtgggcgta gaggaatgtt     3120

tatgccttac cagtgtaaca tgaatcatgt gaaagtgttg ttggaaccag atgccttttc     3180

cagaatgagc ctaacaggaa tttttgacat gaacatgcaa atctggaaga tcctgaggta     3240

tgatgatacg agatcgaggg tacgcgcatg cgaatgcgga ggcaagcatg ccaggttcca     3300

gccggtgtgt gtagatgtga ctgaagatct cagaccggat catttggtta ttgcccgcac     3360

tggagcagag ttcggatcca gtggagaaga aactgactaa ggtgagtatt gggaaaactt     3420

tggggtggga ttttcagatg gacagattga gtaaaaattt gttttttctg tcttgcagct     3480

gtcatgagtg gaaacgcttc ttttaagggg ggagtcttca gcccttatct gacagggcgt     3540

ctcccatcct gggcaggagt tcgtcagaat gttatgggat ctactgtgga tggaagaccc     3600

gtccaacccg ccaattcttc aacgctgacc tatgctactt taagttcttc acctttggac     3660

gcagctgcag ctgccgccgc cgcttctgtt gccgctaaca ctgtgcttgg aatgggttac     3720

tatggaagca tcatggctaa ttccacttcc tctaataacc cttctaccct gactcaggac     3780

aagttacttg tccttttggc ccagctggag gctttgaccc aacgtctggg tgaactttct     3840

cagcaggtgg tcgagttgcg agtacaaact gagtctgctg tcggcacggc aaagtctaaa     3900

taaaaaaatc ccagaatcaa tgaataaata aacaagcttg ttgttgattt aaaatcaagt     3960

gtttttattt catttttcgc gcacggtatg ccctagacca ccgatctcta tcattgagaa     4020

ctcggtggat tttttccagg atcctataga ggtgggattg aatgtttaga tacatgggca     4080

ttaggccgtc tttggggtgg agatagctcc attgaaggga ttcatgctcc ggggtagtgt     4140

tgtaaatcac ccagtcataa caaggtcgca gtgcatggtg ttgcacaata tcttttagaa     4200

gtaggctgat tgccacagat aagcccttgg tgtaggtgtt tacaaaccgg ttgagctggg     4260

atgggtgcat tcggggtgaa attatgtgca ttttggattg gatttttaag ttggcaatat     4320

tgccgccaag atcccgtctt gggttcatgt tatgaaggac caccaagacg gtgtatccgg     4380

tacatttagg aaatttatcg tgcagcttgg atggaaaagc gtggaaaaat ttggagacac     4440

ccttgtgtcc tccaagattt tccatgcact catccatgat aatagcaatg gggccgtggg     4500

cagcggcgcg ggcaaacacg ttccgtgggt ctgacacatc atagttatgt tcctgagtta     4560

aatcatcata agccatttta atgaatttgg ggcggagagt accagattgg ggtatgaatg     4620

ttccttcggg ccccggagca tagttcccct cacagatttg catttcccaa gctttcagtt     4680

ccgagggtgg aatcatgtcc acctgggggg ctatgaaaaa caccgtttct ggggcggggg     4740

tgattaattg tgatgatagc aaatttctga gcaattgaga tttgccacat ccggtggggc     4800

cataaatgat tccgattacg ggttgcaggt ggtagtttag ggaacggcaa ctgccgtctt     4860

ctcgaagcaa gggggccacc tcgttcatca tttcccttac atgcatattt tcccgcacca     4920

aatccattag gaggcgctct cctcctagtg atagaagttc ttgtagtgag gaaaagtttt     4980

tcagcggttt cagaccgtca gccatgggca ttttggagag agtttgctgc aaaagttcta     5040

gtctgttcca cagttcagtg atgtgttcta tggcatctcg atccagcaga cctcctcgtt     5100

tcgcgggttt ggacggctcc tggaataggg tatgagacga tgggcgtcca gcgctgccag     5160

ggttcggtcc ttccagggtc tcagtgttcg agtcagggtt gtttccgtca cagtgaaggg     5220

gtgtgcgcct gcttgggcgc ttgccagggt gcgcttcaga ctcatcctgc tggtcgaaaa     5280

cttctgtcgc ttggcgccct gtatgtcggc caagtagcag tttaccatga gttcgtagtt     5340

gagcgcctcg gctgcgtggc ctttggcgcg gagcttacct ttggaagttt tcttgcatac     5400

cgggcagtat aggcatttca gcgcatacaa cttgggcgca aggaaaacgg attctgggga     5460

gtatgcatct gcgccgcagg aggcgcaaac agtttcacat tccaccagcc aggttaaatc     5520

cggttcattg gggtcaaaaa caagttttcc gccatatttt ttgatgcgtt tcttaccttt     5580

ggtctccatg agttcgtgtc ctcgttgagt gacaaacagg ctgtccgtgt ccccgtagac     5640

tgattttaca ggcctcttct ccagtggagt gcctcggtct tcttcgtaca ggaactctga     5700

ccactctgat acaaaggcgc gcgtccaggc cagcacaaag gaggctatgt gggaggggta     5760

gcgatcgttg tcaaccaggg ggtccacctt ttccaaagta tgcaaacaca tgtcaccctc     5820

ttcaacatcc aggaatgtga ttggcttgta ggtgtatttc acgtgacctg gggtccccgc     5880

tgggggggta taaaaggggg cggttctttg ctcttcctca ctgtcttccg gatcgctgtc     5940

caggaacgtc agctgttggg gtaggtattc cctctcgaag gcgggcatga cctctgcact     6000

caggttgtca gtttctaaga acgaggagga tttgatattg acagtgccgg ttgagatgcc     6060

tttcatgagg ttttcgtcca tctggtcaga aaacacaatt tttttattgt caagtttggt     6120

ggcaaatgat ccatacaggg cgttggataa aagtttggca atggatcgca tggtttggtt     6180

cttttccttg tccgcgcgct ctttggcggc gatgttgagt tggacatact cgcgtgccag     6240

gcacttccat tcggggaaga tagttgttaa ttcatctggc acgattctca cttgccaccc     6300

tcgattatgc aaggtaatta aatccacact ggtggccacc tcgcctcgaa ggggttcatt     6360

ggtccaacag agcctacctc ctttcctaga acagaaaggg ggaagtgggt ctagcataag     6420

ttcatcggga gggtctgcat ccatggtaaa gattcccgga agtaaatcct tatcaaaata     6480

gctgatggga gtggggtcat ctaaggccat ttgccattct cgagctgcca gtgcgcgctc     6540

atatgggtta aggggactgc cccatggcat gggatgggtg agtgcagagg catacatgcc     6600

acagatgtca tagacgtaga tgggatcctc aaagatgcct atgtaggttg gatagcatcg     6660

cccccctctg atacttgctc gcacatagtc atatagttca tgtgatggcg ctagcagccc     6720

cggacccaag ttggtgcgat tgggtttttc tgttctgtag acgatctggc gaaagatggc     6780

gtgagaattg gaagagatgg tgggtctttg aaaaatgttg aaatgggcat gaggtagacc     6840

tacagagtct ctgacaaagt gggcataaga ttcttgaagc ttggttacca gttcggcggt     6900

gacaagtacg tctagggcgc agtagtcaag tgtttcttga atgatgtcat aacctggttg     6960

gtttttcttt tcccacagtt cgcggttgag aaggtattct tcgcgatcct tccagtactc     7020

ttctagcgga aacccgtctt tgtctgcacg gtaagatcct agcatgtaga actgattaac     7080

tgccttgtaa gggcagcagc ccttctctac gggtagagag tatgcttgag cagcttttcg     7140

tagcgaagcg tgagtaaggg caaaggtgtc tctgaccatg actttgagga attggtattt     7200

gaagtcgatg tcgtcacagg ctccctgttc ccagagttgg aagtctaccc gtttcttgta     7260

ggcggggttg ggcaaagcga aagtaacatc attgaagaga atcttgccgg ccctgggcat     7320

gaaattgcga gtgatgcgaa aaggctgtgg tacttccgct cggttattga taacctgggc     7380

agctaggacg atctcgtcga aaccgttgat gttgtgtcct acgatgtata attctatgaa     7440

acgcggcgtg cctctgacgt gaggtagctt actgagctca tcaaaggtta ggtctgtggg     7500

gtcagataag gcgtagtgtt cgagagccca ttcgtgcagg tgaggattcg ctttaaggaa     7560

ggaggaccag aggtccactg ccagtgctgt ttgtaactgg tcccggtact gacgaaaatg     7620

ccgtccgact gccatttttt ctggggtgac gcaatagaag gtttgggggt cctgccgcca     7680

gcgatcccac ttgagtttta tggcgaggtc ataggcgatg ttgacgagcc gctggtctcc     7740

agagagtttc atgaccagca tgaaggggat tagctgcttg ccaaaggacc ccatccaggt     7800

gtaggtttcc acatcgtagg tgagaaagag cctttctgtg cgaggatgag agccaatcgg     7860

gaagaactgg atctcctgcc accagttgga ggaatggctg ttgatgtgat ggaagtagaa     7920

ctccctgcga cgcgccgagc attcatgctt gtgcttgtac agacggccgc agtagtcgca     7980

gcgttgcacg ggttgtatct cgtgaatgag ttgtacctgg cttcccttga cgagaaattt     8040

cagtgggaag ccgaggcctg gcgattgtat ctcgtgcttt actatgttgt ctgcatcggc     8100

ctgttcatct tctgtctcga tggtggtcat gctgacgagc cctcgcggga ggcaagtcca     8160

gacctcggcg cggcaggggc ggagctcgag gacgagagcg cgcaggctgg agctgtccag     8220

ggtcctgaga cgctgcggac tcaggttagt aggcagtgtc aggagattaa cttgcatgat     8280

cttttggagg gcgtgcggga ggttcagata gtacttgatc tcaacgggtc cgttggtgga     8340

gatgtcgatg gcttgcaggg ttccgtgtcc cttgggcgct accaccgtgc ccttgttttt     8400

cattttggac ggcggtggct ctgttgcttc ttgcatgttt agaagcggtg tcgagggcgc     8460

gcaccgggcg gcaggggcgg ctcgggaccc ggcggcatgg ctggcagtgg tacgtcggcg     8520

ccgcgcgcgg gtaggttctg gtactgcgcc ctgagaagac tcgcatgcgc gacgacgcgg     8580

cggttgacat cctggatctg acgcctctgg gtgaaagcta ccggccccgt gagcttgaac     8640

ctgaaagaga gttcaacaga atcaatctcg gtatcgttga cggcggcttg cctaaggatt     8700

tcttgcacgt caccagagtt gtcctggtag gcgatctccg ccatgaactg ctcgatctct     8760

tcctcttgaa gatctccgcg gcccgctctc tcgacggtgg ccgcgaggtc gttggagatg     8820

cgcccaatga gttgagagaa tgcattcatg cccgcctcgt tccagacgcg gctgtagacc     8880

acggccccca cgggatctct cgcgcgcatg accacctggg cgaggttgag ctccacgtgg     8940

cgggtgaaga ccgcatagtt gcataggcgc tggaaaaggt agttgagtgt ggtggcgatg     9000

tgctcggtga cgaagaaata catgatccat cgtctcagcg gcatctcgct gacatcgccc     9060

agagcttcca agcgctccat ggcctcgtag aagtccacgg caaaattaaa aaactgggag     9120

tttcgcgcgg acacggtcaa ctcctcttcc agaagacgga taagttcggc gatggtggtg     9180

cgcacctcgc gctcgaaagc ccctgggatt tcttcctcaa tctcttcttc ttccactaac     9240

atctcttcct cttcaggtgg ggctgcagga ggagggggaa cgcggcgacg ccggcggcgc     9300

acgggcagac ggtcgatgaa tctttcaatg acctctccgc ggcggcggcg catggtttca     9360

gtgacggcgc ggccgttctc gcgcggtcgc agagtaaaaa caccgccgcg catctcctta     9420

aagtggtgac tgggaggttc tccgtttggg agggagaggg cgctgattat acattttatt     9480

aattggcccg tagggactgc acgcagagat ctgatcgtgt caagatccac gggatctgaa     9540

aacctttcga cgaaagcgtc taaccagtca cagtcacaag gtaggctgag tacggcttct     9600

tgtgggcggg ggtggttatg tgttcggtct gggtcttctg tttcttcttc atctcgggaa     9660

ggtgagacga tgctgctggt gatgaaatta aagtaggcag ttctaagacg gcggatggtg     9720

gcgaggagca ccaggtcttt gggtccggct tgctggatac gcaggcgatt ggccattccc     9780

caagcattat cctgacatct agcaagatct ttgtagtagt cttgcatgag ccgttctacg     9840

ggcacttctt cctcacccgt tctgccatgc atacgtgtga gtccaaatcc gcgcattggt     9900

tgtaccagtg ccaagtcagc tacgactctt tcggcgagga tggcttgctg tacttgggta     9960

agggtggctt gaaagtcatc aaaatccaca aagcggtggt aagctcctgt attaatggtg    10020

taagcacagt tggccatgac tgaccagtta actgtctggt gaccagggcg cacgagctcg    10080

gtgtatttaa ggcgcgaata ggcgcgggtg tcaaagatgt aatcgttgca ggtgcgcacc    10140

agatactggt accctataag aaaatgcggc ggtggttggc ggtagagagg ccatcgttct    10200

gtagctggag cgccaggggc gaggtcttcc aacataaggc ggtgatagcc gtagatgtac    10260

ctggacatcc aggtgattcc tgcggcggta gtagaagccc gaggaaactc gcgtacgcgg    10320

ttccaaatgt tgcgtagcgg catgaagtag ttcattgtag gcacggtttg accagtgagg    10380

cgcgcgcagt cattgatgct ctatagacac ggagaaaatg aaagcgttca gcgactcgac    10440

tccgtagcct ggaggaacgt gaacgggttg ggtcgcggtg taccccggtt cgagacttgt    10500

actcgagccg gccggagccg cggctaacgt ggtattggca ctcccgtctc gacccagcct    10560

acaaaaatcc aggatacgga atcgagtcgt tttgctggtt tccgaatggc agggaagtga    10620

gtcctatttt ttttttttgc cgctcagatg catcccgtgc tgcgacagat gcgcccccaa    10680

caacagcccc cctcgcagca gcagcagcag caatcacaaa aggctgtccc tgcaactact    10740

gcaactgccg ccgtgagcgg tgcgggacag cccgcctatg atctggactt ggaagagggc    10800

gaaggactgg cacgtctagg tgcgccttca cccgagcggc atccgcgagt tcaactgaaa    10860

aaagattctc gcgaggcgta tgtgccccaa cagaacctat ttagagacag aagcggcgag    10920

gagccggagg agatgcgagc ttcccgcttt aacgcgggtc gtgagctgcg tcacggtttg    10980

gaccgaagac gagtgttgcg ggacgaggat ttcgaagttg atgaaatgac agggatcagt    11040

cctgccaggg cacacgtggc tgcagccaac cttgtatcgg cttacgagca gacagtaaag    11100

gaagagcgta acttccaaaa gtcttttaat aatcatgtgc gaaccctgat tgcccgcgaa    11160

gaagttaccc ttggtttgat gcatttgtgg gatttgatgg aagctatcat tcagaaccct    11220

actagcaaac ctctgaccgc ccagctgttt ctggtggtgc aacacagcag agacaatgag    11280

gctttcagag aggcgctgct gaacatcacc gaacccgagg ggagatggtt gtatgatctt    11340

atcaacattc tacagagtat catagtgcag gagcggagcc tgggcctggc cgagaaggtg    11400

gctgccatca attactcggt tttgagcttg ggaaaatatt acgctcgcaa aatctacaag    11460

actccatacg ttcccataga caaggaggtg aagatagatg ggttctacat gcgcatgacg    11520

ctcaaggtct tgaccctgag cgatgatctt ggggtgtatc gcaatgacag aatgcatcgc    11580

gcggttagcg ccagcaggag gcgcgagtta agcgacaggg aactgatgca cagtttgcaa    11640

agagctctga ctggagctgg aaccgagggt gagaattact tcgacatggg agctgacttg    11700

cagtggcagc ctagtcgcag ggctctgagc gccgcgacgg caggatgtga gcttccttac    11760

atagaagagg cggatgaagg cgaggaggaa gagggcgagt acttggaaga ctgatggcac    11820

aacccgtgtt ttttgctaga tggaacagca agcaccggat cccgcaatgc gggcggcgct    11880

gcagagccag ccgtccggca ttaactcctc ggacgattgg acccaggcca tgcaacgtat    11940

catggcgttg acgactcgca accccgaagc ctttagacag caaccccagg ccaaccgtct    12000

atcggccatc atggaagctg tagtgccttc ccgctctaat cccactcatg agaaggtcct    12060

ggccatcgtg aacgcgttgg tggagaacaa agctattcgt ccagatgagg ccggactggt    12120

atacaacgct ctcttagaac gcgtggctcg ctacaacagt agcaatgtgc aaaccaattt    12180

ggaccgtatg ataacagatg tacgcgaagc cgtgtctcag cgcgaaaggt tccagcgtga    12240

tgccaacctg ggttcgctgg tggcgttaaa tgctttcttg agtactcagc ctgctaatgt    12300

gccgcgtggt caacaggatt atactaactt tttaagtgct ttgagactga tggtatcaga    12360

agtacctcag agcgaagtgt atcagtccgg tcctgattac ttctttcaga ctagcagaca    12420

gggcttgcag acggtaaatc tgagccaagc ttttaaaaac cttaaaggtt tgtggggagt    12480

gcatgccccg gtaggagaaa gagcaaccgt gtctagcttg ttaactccga actcccgcct    12540

attattactg ttggtagctc ctttcaccga cagcggtagc atcgaccgta attcctattt    12600

gggttaccta ctaaacctgt atcgcgaagc catagggcaa agtcaggtgg acgagcagac    12660

ctatcaagaa attacccaag tcagtcgcgc tttgggacag gaagacactg gcagtttgga    12720

agccactctg aacttcttgc ttaccaatcg gtctcaaaag atccctcctc aatatgctct    12780

tactgcggag gaggagagga tccttagata tgtgcagcag agcgtgggat tgtttctgat    12840

gcaagagggg gcaactccga ctgcagcact ggacatgaca gcgcgaaata tggagcccag    12900

catgtatgcc agtaaccgac ctttcattaa caaactgctg gactacttgc acagagctgc    12960

cgctatgaac tctgattatt tcaccaatgc catcttaaac ccgcactggc tgcccccacc    13020

tggtttctac acgggcgaat atgacatgcc cgaccctaat gacggatttc tgtgggacga    13080

cgtggacagc gatgtttttt cacctctttc tgatcatcgc acgtggaaaa aggaaggcgg    13140

cgatagaatg cattcttctg catcgctgtc cggggtcatg ggtgctaccg cggctgagcc    13200

cgagtctgca agtccttttc ctagtctacc cttttctcta cacagtgtac gtagcagcga    13260

agtgggtaga ataagtcgcc cgagtttaat gggcgaagag gagtatctaa acgattcctt    13320

gctcagaccg gcaagagaaa aaaatttccc aaacaatgga atagaaagtt tggtggataa    13380

aatgagtaga tggaagactt atgctcagga tcacagagac gagcctggga tcatggggat    13440

tacaagtaga gcgagccgta gacgccagcg ccatgacaga cagaggggtc ttgtgtggga    13500

cgatgaggat tcggccgatg atagcagcgt gctggacttg ggtgggagag gaaggggcaa    13560

cccgtttgct catttgcgcc ctcgcttggg tggtatgttg taaaaaaaaa taaaaaaaaa    13620

actcaccaag gccatggcga cgagcgtacg ttcgttcttc tttattatct gtgtctagta    13680

taatgaggcg agtcgtgcta ggcggagcgg tggtgtatcc ggagggtcct cctccttcgt    13740

acgagagcgt gatgcagcag cagcaggcga cggcggtgat gcaatcccca ctggaggctc    13800

cctttgtgcc tccgcgatac ctggcaccta cggagggcag aaacagcatt cgttattcgg    13860

aactggcacc tcagtacgat accaccaggt tgtatctggt ggacaacaag tcggcggaca    13920

ttgcttctct gaactatcag aatgaccaca gcaacttctt gaccacggtg gtgcaaaaca    13980

atgactttac ccctacggaa gccagcaccc agaccattaa ctttgatgaa cgatcgcggt    14040

ggggcggtca gctaaagacc atcatgcata ctaacatgcc aaacgtgaac gagtatatgt    14100

ttagtaacaa gttcaaagcg cgtgtgatgg tgtccagaaa acctcccgac ggtgctgcag    14160

ttggggatac ttatgatcac aagcaggata ttttgaaata tgagtggttc gagtttactt    14220

tgccagaagg caacttttca gttactatga ctattgattt gatgaacaat gccatcatag    14280

ataattactt gaaagtgggt agacagaatg gagtgcttga aagtgacatt ggtgttaagt    14340

tcgacaccag gaacttcaag ctgggatggg atcccgaaac caagttgatc atgcctggag    14400

tgtatacgta tgaagccttc catcctgaca ttgtcttact gcctggctgc ggagtggatt    14460

ttaccgagag tcgtttgagc aaccttcttg gtatcagaaa aaaacagcca tttcaagagg    14520

gttttaagat tttgtatgaa gatttagaag gtggtaatat tccggccctc ttggatgtag    14580

atgcctatga gaacagtaag aaagaacaaa aagccaaaat agaagctgct acagctgctg    14640

cagaagctaa ggcaaacata gttgccagcg actctacaag ggttgctaac gctggagagg    14700

tcagaggaga caattttgcg ccaacacctg ttccgactgc agaatcatta ttggccgatg    14760

tgtctgaagg aacggacgtg aaactcacta ttcaacctgt agaaaaagat agtaagaata    14820

gaagctataa tgtgttggaa gacaaaatca acacagccta tcgcagttgg tatctttcgt    14880

acaattatgg cgatcccgaa aaaggagtgc gttcctggac attgctcacc acctcagatg    14940

tcacctgcgg agcagagcag gtctactggt cgcttccaga catgatgaag gatcctgtca    15000

ctttccgctc cactagacaa gtcagtaact accctgtggt gggtgcagag cttatgcccg    15060

tcttctcaaa gagcttctac aacgaacaag ctgtgtactc ccagcagctc cgccagtcca    15120

cctcgcttac gcacgtcttc aaccgctttc ctgagaacca gattttaatc cgtccgccgg    15180

cgcccaccat taccaccgtc agtgaaaacg ttcctgctct cacagatcac gggaccctgc    15240

cgttgcgcag cagtatccgg ggagtccaac gtgtgaccgt tactgacgcc agacgccgca    15300

cctgtcccta cgtgtacaag gcactgggca tagtcgcacc gcgcgtcctt tcaagccgca    15360

ctttctaaaa aaaaaaaaaa tgtccattct tatctcgccc agtaataaca ccggttgggg    15420

tctgcgcgct ccaagcaaga tgtacggagg cgcacgcaaa cgttctaccc aacatcctgt    15480

ccgtgttcgc ggacattttc gcgctccatg gggcgccctc aagggccgca ctcgcgttcg    15540

aaccaccgtc gatgatgtaa tcgatcaggt ggttgccgac gcccgtaatt atactcctac    15600

tgcgcctaca tctactgtgg atgcagttat tgacagtgta gtggctgacg ctcgcaacta    15660

tgctcgacgt aagagccggc gaaggcgcat tgccagacgc caccgagcta ccactgccat    15720

gcgagccgca agagctctgc tacgaagagc tagacgcgtg gggcgaagag ccatgcttag    15780

ggcggccaga cgtgcagctt cgggcgccag cgccggcagg tcccgcaggc aagcagccgc    15840

tgtcgcagcg gcgactattg ccgacatggc ccaatcgcga agaggcaatg tatactgggt    15900

gcgtgacgct gccaccggtc aacgtgtacc cgtgcgcacc cgtccccctc gcacttagaa    15960

gatactgagc agtctccgat gttgtgtccc agcggcgagg atgtccaagc gcaaatacaa    16020

ggaagaaatg ctgcaggtta tcgcacctga agtctacggc caaccgttga aggatgaaaa    16080

aaaaccccgc aaaatcaagc gggttaaaaa ggacaaaaaa gaagaggaag atggcgatga    16140

tgggctggcg gagtttgtgc gcgagtttgc cccacggcga cgcgtgcaat ggcgtgggcg    16200

caaagttcga catgtgttga gacctggaac ttcggtggtc tttacacccg gcgagcgttc    16260

aagcgctact tttaagcgtt cctatgatga ggtgtacggg gatgatgata ttcttgagca    16320

ggcggctgac cgattaggcg agtttgctta tggcaagcgt agtagaataa cttccaagga    16380

tgagacagtg tcgataccct tggatcatgg aaatcccacc cctagtctta aaccggtcac    16440

tttgcagcaa gtgttacccg taactccgcg aacaggtgtt aaacgcgaag gtgaagattt    16500

gtatcccact atgcaactga tggtacccaa acgccagaag ttggaggacg ttttggagaa    16560

agtaaaagtg gatccagata ttcaacctga ggttaaagtg agacccatta agcaggtagc    16620

gcctggtctg ggggtacaaa ctgtagacat taagattccc actgaaagta tggaagtgca    16680

aactgaaccc gcaaagccta ctgccacctc cactgaagtg caaacggatc catggatgcc    16740

catgcctatt acaactgacg ccgccggtcc cactcgaaga tcccgacgaa agtacggtcc    16800

agcaagtctg ttgatgccca attatgttgt acacccatct attattccta ctcctggtta    16860

ccgaggcact cgctactatc gcagccgaaa cagtacctcc cgccgtcgcc gcaagacacc    16920

tgcaaatcgc agtcgtcgcc gtagacgcac aagcaaaccg actcccggcg ccctggtgcg    16980

gcaagtgtac cgcaatggta gtgcggaacc tttgacactg ccgcgtgcgc gttaccatcc    17040

gagtatcatc acttaatcaa tgttgccgct gcctccttgc agatatggcc ctcacttgtc    17100

gccttcgcgt tcccatcact ggttaccgag gaagaaactc gcgccgtaga agagggatgt    17160

tgggacgcgg aatgcgacgc tacaggcgac ggcgtgctat ccgcaagcaa ttgcggggtg    17220

gttttttacc agccttaatt ccaattatcg ctgctgcaat tggcgcgata ccaggcatag    17280

cttccgtggc ggttcaggcc tcgcaacgac attgacattg gaaaaaaacg tataaataaa    17340

aaaaaaaaaa tacaatggac tctgacactc ctggtcctgt gactatgttt tcttagagat    17400

ggaagacatc aatttttcat ccttggctcc gcgacacggc acgaagccgt acatgggcac    17460

ctggagcgac atcggcacga gccaactgaa cgggggcgcc ttcaattgga gcagtatctg    17520

gagcgggctt aaaaattttg gctcaaccat aaaaacatac gggaacaaag cttggaacag    17580

cagtacagga caggcgctta gaaataaact taaagaccag aacttccaac aaaaagtagt    17640

cgatgggata gcttccggca tcaatggagt ggtagatttg gctaaccagg ctgtgcagaa    17700

aaagataaac agtcgtttgg acccgccgcc agcaacccca ggtgaaatgc aagtggagga    17760

agaaattcct ccgccagaaa aacgaggcga caagcgtccg cgtcccgatt tggaagagac    17820

gctggtgacg cgcgtagatg aaccgccttc ttatgaggaa gcaacgaagc ttggaatgcc    17880

caccactaga ccgatagccc caatggccac cggggtgatg aaaccttctc agttgcatcg    17940

acccgtcacc ttggatttgc cccctccccc tgctgctact gctgtacccg cttctaagcc    18000

tgtcgctgcc ccgaaaccag tcgccgtagc caggtcacgt cccgggggcg ctcctcgtcc    18060

aaatgcgcac tggcaaaata ctctgaacag catcgtgggt ctaggcgtgc aaagtgtaaa    18120

acgccgtcgc tgcttttaat taaatatgga gtagcgctta acttgcctat ctgtgtatat    18180

gtgtcattac acgccgtcac agcagcagag gaaaaaagga agaggtcgtg cgtcgacgct    18240

gagttacttt caagatggcc accccatcga tgctgcccca atgggcatac atgcacatcg    18300

ccggacagga tgcttcggag tacctgagtc cgggtctggt gcagttcgcc cgcgccacag    18360

acacctactt caatctggga aataagttta gaaatcccac cgtagcgccg acccacgatg    18420

tgaccaccga ccgtagccag cggctcatgt tgcgcttcgt gcccgttgac cgggaggaca    18480

atacatactc ttacaaagtg cggtacaccc tggccgtggg cgacaacaga gtgctggata    18540

tggccagcac gttctttgac attaggggtg tgttggacag aggtcccagt ttcaaaccct    18600

attctggtac ggcttacaac tccctggctc ctaaaggcgc tccaaataca tctcagtgga    18660

ttgcagaagg tgtaaaaaat acaactggtg aggaacacgt aacagaagag gaaaccaata    18720

ctactactta cacttttggc aatgctcctg taaaagctga agctgaaatt acaaaagaag    18780

gactcccagt aggtttggaa gtttcagatg aagaaagtaa accgatttat gctgataaaa    18840

catatcagcc agaacctcag ctgggagatg aaacttggac tgaccttgat ggaaaaaccg    18900

aaaagtatgg aggcagggct ctcaaacccg atactaagat gaaaccatgc tacgggtcct    18960

ttgccaaacc tactaatgtg aaaggcggtc aggcaaaaca aaaaacaacg gagcagccaa    19020

atcagaaagt cgaatatgat atcgacatgg agttttttga tgcggcatcg cagaaaacaa    19080

acttaagtcc taaaattgtc atgtatgcag aaaatgtaaa tttggaaact ccagacactc    19140

atgtagtgta caaacctgga acagaagaca caagttccga agctaatttg ggacaacaat    19200

ctatgcccaa cagacccaac tacattggct tcagagataa ctttattgga cttatgtact    19260

ataacagtac tggtaacatg ggggtgctgg ctggtcaagc gtctcagtta aatgcagtgg    19320

ttgacttgca ggacagaaac acagaacttt cttaccaact cttgcttgac tctctgggcg    19380

acagaaccag atactttagc atgtggaatc aggctgtgga cagttatgat cctgatgtac    19440

gtgttattga aaatcatggt gtggaagatg aacttcccaa ctactgtttt ccactggacg    19500

gcataggtgt tccaacaacc agttacaaat caatagttcc aaatggagac aatgcgccta    19560

attggaagga acctgaagta aatggaacaa gtgagatcgg acagggtaat ttgtttgcca    19620

tggaaattaa ccttcaagcc aatctatggc gaagtttcct ttattccaat gtggctctat    19680

atctcccaga ctcgtacaaa tacaccccgt ccaatgtcac tcttccagaa aacaaaaaca    19740

cctacgacta catgaacggg cgggtggtgc cgccatctct agtagacacc tatgtgaaca    19800

ttggtgccag gtggtctctg gatgccatgg acaatgtcaa cccattcaac caccaccgta    19860

acgctggctt gcgttaccga tccatgcttc tgggtaacgg acgttatgtg cctttccaca    19920

tacaagtgcc tcaaaaattc ttcgctgtta aaaacctgct gcttctccca ggctcctaca    19980

cttatgagtg gaactttagg aaggatgtga acatggttct acagagttcc ctcggtaacg    20040

acctgcgggt agatggcgcc agcatcagtt tcacgagcat caacctctat gctacttttt    20100

tccccatggc tcacaacacc gcttccaccc ttgaagccat gctgcggaat gacaccaatg    20160

atcagtcatt caacgactac ctatctgcag ctaacatgct ctaccccatt cctgccaatg    20220

caaccaatat tcccatttcc attccttctc gcaactgggc ggctttcaga ggctggtcat    20280

ttaccagact gaaaaccaaa gaaactccct ctttggggtc tggatttgac ccctactttg    20340

tctattctgg ttctattccc tacctggatg gtaccttcta cctgaaccac acttttaaga    20400

aggtttccat catgtttgac tcttcagtga gctggcctgg aaatgacagg ttactatctc    20460

ctaacgaatt tgaaataaag cgcactgtgg atggcgaagg ctacaacgta gcccaatgca    20520

acatgaccaa agactggttc ttggtacaga tgctcgccaa ctacaacatc ggctatcagg    20580

gcttctacat tccagaagga tacaaagatc gcatgtattc atttttcaga aacttccagc    20640

ccatgagcag gcaggtggtt gatgaggtca attacaaaga cttcaaggcc gtcgccatac    20700

cctaccaaca caacaactct ggctttgtgg gttacatggc tccgaccatg cgccaaggtc    20760

aaccctatcc cgctaactat ccctatccac tcattggaac aactgccgta aatagtgtta    20820

cgcagaaaaa gttcttgtgt gacagaacca tgtggcgcat accgttctcg agcaacttca    20880

tgtctatggg ggcccttaca gacttgggac agaatatgct ctatgccaac tcagctcatg    20940

ctctggacat gacctttgag gtggatccca tggatgagcc caccctgctt tatcttctct    21000

tcgaagtttt cgacgtggtc agagtgcatc agccacaccg cggcatcatc gaggcagtct    21060

acctgcgtac accgttctcg gccggtaacg ctaccacgta agaagcttct tgcttcttgc    21120

aaatagcagc tgcaaccatg gcctgcggat cccaaaacgg ctccagcgag caagagctca    21180

gagccattgt ccaagacctg ggttgcggac cctatttttt gggaacctac gataagcgct    21240

tcccggggtt catggccccc gataagctcg cctgtgccat tgtaaatacg gccggacgtg    21300

agacgggggg agagcactgg ttggctttcg gttggaaccc acgttctaac acctgctacc    21360

tttttgatcc ttttggattc tcggatgatc gtctcaaaca gatttaccag tttgaatatg    21420

agggtctcct gcgccgcagc gctcttgcta ccaaggaccg ctgtattacg ctggaaaaat    21480

ctacccagac cgtgcagggt ccccgttctg ccgcctgcgg acttttctgc tgcatgttcc    21540

ttcacgcctt tgtgcactgg cctgaccgtc ccatggacgg aaaccccacc atgaaattgc    21600

taactggagt gccaaacaac atgcttcatt ctcctaaagt ccagcccacc ctgtgtgaca    21660

atcaaaaagc actctaccat tttcttaata cccattcgcc ttattttcgc tcccatcgta    21720

cacacatcga aagggccact gcgttcgacc gtatggatgt tcaataatga ctcatgtaaa    21780

caacgtgttc aataaacatc actttatttt tttacatgta tcaaggctct gcattactta    21840

tttatttaca agtcgaatgg gttctgacga gaatcagaat gacccgcagg cagtgatacg    21900

ttgcggaact gatacttggg ttgccacttg aattcgggaa tcaccaactt gggaaccggt    21960

atatcgggca ggatgtcact ccacagcttt ctggtcagct gcaaagctcc aagcaggtca    22020

ggagccgaaa tcttgaaatc acaattagga ccagtgcttt gagcgcgaga gttgcggtac    22080

accggattgc agcactgaaa caccatcagc gacggatgtc tcacgcttgc cagcacggtg    22140

ggatctgcaa tcatgcccac atccagatct tcagcattgg caatgctgaa cggggtcatc    22200

ttgcaggtct gcctacccat ggcgggcacc caattaggct tgtggttgca atcgcagtgc    22260

agggggatca gtatcatctt ggcctgatcc tgtctgattc ctggatacac ggctctcatg    22320

aaagcatcat attgcttgaa agcctgctgg gctttactac cctcggtata aaacatcccg    22380

caggacctgc tcgaaaactg gttagctgca cagccggcat cattcacaca gcagcgggcg    22440

tcattgttag ctatttgcac cacacttctg ccccagcggt tttgggtgat tttggttcgc    22500

tcgggattct cctttaaggc tcgttgtccg ttctcgctgg ccacatccat ctcgataatc    22560

tgctccttct gaatcataat attgccatgc aggcacttca gcttgccctc ataatcattg    22620

cagccatgag gccacaacgc acagcctgta cattcccaat tatggtgggc gatctgagaa    22680

aaagaatgta tcattccctg cagaaatctt cccatcatcg tgctcagtgt cttgtgacta    22740

gtgaaagtta actggatgcc tcggtgctcc tcgtttacgt actggtgaca gatgcgcttg    22800

tattgttcgt gttgctcagg cattagttta aaagaggttc taagttcgtt atccagcctg    22860

tacttctcca tcagcagaca catcacttcc atgcctttct cccaagcaga caccaggggc    22920

aagctaatcg gattcttaac agtgcaggca gcagctcctt tagccagagg gtcatcttta    22980

gcgatcttct caatgcttct tttgccatcc ttctcaacga tgcgcacggg cgggtagctg    23040

aaacccactg ctacaagttg cgcctcttct ctttcttctt cgctgtcttg actgatgtct    23100

tgcatgggga tatgtttggt cttccttggc ttctttttgg ggggtatcgg aggaggagga    23160

ctgtcgctcc gttccggaga cagggaggat tgtgacgttt cgctcaccat taccaactga    23220

ctgtcggtag aagaacctga ccccacacgg cgacaggtgt ttctcttcgg gggcagaggt    23280

ggaggcgatt gcgaagggct gcggtccgac ctggaaggcg gatgactggc agaacccctt    23340

ccgcgttcgg gggtgtgctc cctgtggcgg tcgcttaact gatttccttc gcggctggcc    23400

attgtgttct cctaggcaga gaaacaacag acatggaaac tcagccattg ctgtcaacat    23460

cgccacgagt gccatcacat ctcgtcctca gcgacgagga aaaggagcag agcttaagca    23520

ttccaccgcc cagtcctgcc accacctcta ccctagaaga taaggaggtc gacgcatctc    23580

atgacatgca gaataaaaaa gcgaaagagt ctgagacaga catcgagcaa gacccgggct    23640

atgtgacacc ggtggaacac gaggaagagt tgaaacgctt tctagagaga gaggatgaaa    23700

actgcccaaa acaacgagca gataactatc accaagatgc tggaaatagg gatcagaaca    23760

ccgactacct catagggctt gacggggaag acgcgctcct taaacatcta gcaagacagt    23820

cgctcatagt caaggatgca ttattggaca gaactgaagt gcccatcagt gtggaagagc    23880

tcagccgcgc ctacgagctt aacctctttt cacctcgtac tccccccaaa cgtcagccaa    23940

acggcacctg cgagccaaat cctcgcttaa acttttatcc agcttttgct gtgccagaag    24000

tactggctac ctatcacatc ttttttaaaa atcaaaaaat tccagtctcc tgccgcgcta    24060

atcgcacccg cgccgatgcc ctactcaatc tgggacctgg ttcacgctta cctgatatag    24120

cttccttgga agaggttcca aagatcttcg agggtctggg caataatgag actcgggccg    24180

caaatgctct gcaaaaggga gaaaatggca tggatgagca tcacagcgtt ctggtggaat    24240

tggaaggcga taatgccaga ctcgcagtac tcaagcgaag catcgaggtc acacacttcg    24300

catatcccgc tgtcaacctg ccccctaaag tcatgacggc ggtcatggac cagttactca    24360

ttaagcgcgc aagtcccctt tcagaagaca tgcatgaccc agatgcctgt gatgagggta    24420

aaccagtggt cagtgatgag cagctaaccc gatggctggg caccgactct cccagggatt    24480

tggaagagcg tcgcaagctt atgatggccg tggtgctggt taccgtagaa ctagagtgtc    24540

tccgacgttt ctttaccgat tcagaaacct tgcgcaaact cgaagagaat ctgcactaca    24600

cttttagaca cggctttgtg cggcaggcat gcaagatatc taacgtggaa ctcaccaacc    24660

tggtttccta catgggtatt ctgcatgaga atcgcctagg acaaagcgtg ctgcacagca    24720

ccctgaaggg ggaagcccgc cgtgattaca tccgcgattg tgtctatctg tacctgtgcc    24780

acacgtggca aaccggcatg ggtgtatggc agcaatgttt agaagaacag aacttgaaag    24840

agcttgacaa gctcttacag aaatctctta aggttctgtg gacagggttc gacgagcgca    24900

ccgtcgcttc cgacctggca gacctcatct tcccagagcg tctcagggtt actttgcgaa    24960

acggattgcc tgactttatg agccagagca tgcttaacaa ttttcgctct ttcatcctgg    25020

aacgctccgg tatcctgccc gccacctgct gcgcactgcc ctccgacttt gtgcctctca    25080

cctaccgcga gtgccccccg ccgctatgga gtcactgcta cctgttccgt ctggccaact    25140

atctctccta ccactcggat gtgatcgagg atgtgagcgg agacggcttg ctggagtgtc    25200

actgccgctg caatctgtgc acgccccacc ggtccctagc ttgcaacccc cagttgatga    25260

gcgaaaccca gataataggc acctttgaat tgcaaggccc cagcagccaa ggcgatgggt    25320

cttctcctgg gcaaagttta aaactgaccc cgggactgtg gacctccgcc tacttgcgca    25380

agtttgctcc ggaagattac cacccctatg aaatcaagtt ctatgaggac caatcacagc    25440

ctccaaaggc cgaactttcg gcctgcgtca tcacccaggg ggcaattctg gcccaattgc    25500

aagccatcca aaaatcccgc caagaatttc tactgaaaaa gggtaagggg gtctaccttg    25560

acccccagac cggcgaggaa ctcaacacaa ggttccctca ggatgtccca acgacgagaa    25620

aacaagaagt tgaaggtgca gccgccgccc ccagaagata tggaggaaga ttgggacagt    25680

caggcagagg aggcggagga ggacagtctg gaggacagtc tggaggaaga cagtttggag    25740

gaggaaaacg aggaggcaga ggaggtggaa gaagtaaccg ccgacaaaca gttatcctcg    25800

gctgcggaga caagcaacag cgctaccatc tccgctccga gtcgaggaac ccggcggcgt    25860

cccagcagta gatgggacga gaccggacgc ttcccgaacc caaccagcgc ttccaagacc    25920

ggtaagaagg atcggcaggg atacaagtcc tggcgggggc ataagaatgc catcatctcc    25980

tgcttgcatg agtgcggggg caacatatcc ttcacgcggc gctacttgct attccaccat    26040

ggggtgaact ttccgcgcaa tgttttgcat tactaccgtc acctccacag cccctactat    26100

agccagcaaa tcccggcagt ctcgacagat aaagacagcg gcggcgacct ccaacagaaa    26160

accagcagcg gcagttagaa aatacacaac aagtgcagca acaggaggat taaagattac    26220

agccaacgag ccagcgcaaa cccgagagtt aagaaatcgg atctttccaa ccctgtatgc    26280

catcttccag cagagtcggg gtcaagagca ggaactgaaa ataaaaaacc gatctctgcg    26340

ttcgctcacc agaagttgtt tgtatcacaa gagcgaagat caacttcagc gcactctcga    26400

ggacgccgag gctctcttca acaagtactg cgcgctgact cttaaagagt aggcagcgac    26460

cgcgcttatt caaaaaaggc gggaattaca tcatcctcga catgagtaaa gaaattccca    26520

cgccttacat gtggagttat caaccccaaa tgggattggc ggcaggcgcc tcccaggact    26580

actccacccg catgaattgg ctcagcgccg ggccttctat gatttctcga gttaatgata    26640

tacgcgccta ccgaaaccaa atacttttgg aacagtcagc tcttaccacc acgccccgcc    26700

aacaccttaa tcccagaaat tggcccgccg ccctagtgta ccaggaaagt cccgctccca    26760

ccactgtatt acttcctcga gacgcccagg ccgaagtcca aatgactaat gcaggtgcgc    26820

agttagctgg cggctccacc ctatgtcgtc acaggcctcg gcataatata aaacgcctga    26880

tgatcagagg ccgaggtatc cagctcaacg acgagtcggt gagctctccg cttggtctac    26940

gaccagacgg aatctttcag attgccggct gcgggagatc ttccttcacc cctcgtcagg    27000

ctgttctgac tttggaaagt tcgtcttcgc aaccccgctc gggcggaatc gggaccgttc    27060

aatttgtgga ggagtttact ccctctgtct acttcaaccc cttctccgga tctcctgggc    27120

attacccgga cgagttcata ccgaacttcg acgcgattag cgagtcagtg gacggctacg    27180

attgatgtct ggtgacgcgg ctgagctatc tcggctgcga catctagacc actgccgccg    27240

ctttcgctgc tttgcccggg aactcattga gttcatctac ttcgaactcc ccaaggatca    27300

ccctcaaggt ccggcccacg gagtgcggat ttctatcgaa ggcaaaatag actctcgcct    27360

gcaacgaatt ttctcccagc ggcccgtgct gatcgagcga gaccagggaa acaccacggt    27420

ttccatctac tgcatttgta atcaccccgg attgcatgaa agcctttgct gtcttatgtg    27480

tactgagttt aataaaaact gaattaagac tctcctacgg actgccgctt cttcaacccg    27540

gattttacaa ccagaagaac gaaacttttc ctgtcgtcca ggactctgtt aacttcacct    27600

ttcctactca caaactagaa gctcaacgac tacaccgctt ttccagaagc attttcccta    27660

ctaatactac tttcaaaacc ggaggtgagc tccaaggtct tcctacagaa aacccttggg    27720

tggaagcggg ccttgtagtg ctaggaattc ttgcgggtgg gcttgtgatt attctttgct    27780

acctatacac accttgcttc actttcttag tggtgttgtg gtattggttt aaaaaatggg    27840

gcccatacta gtcttgcttg ttttactttc gcttttggaa ccgggttctg ccaattacga    27900

tccatgtcta gacttcgacc cagaaaactg cacacttact tttgcacccg acacaagccg    27960

catctgtgga gttcatcgcc tctcttacga acttggcccc caacgacaaa aatttacctg    28020

catggtggga atcaacccca tagttatcac ccagcaaagt ggagatacta agggttgcat    28080

tcactgctcc tgcgattcca tcgagtgcac ctacaccctg ctgaagaccc tatgcggcct    28140

aagagacctg ctaccaatga attaaaaaat gattaataaa aaatcactta cttgaaatca    28200

gcaataaggt ctctgttgaa attttctccc agcagcacct cacttccctc ttcccaactc    28260

tggtattcta aaccccgttc agcggcatac tttctccata ctttaaaggg gatgtcaaat    28320

tttagctcct ctcctgtacc cacaatcttc atgtctttct tcccagatga ccaagagagt    28380

ccggctcagt gactccttca accctgtcta cccctatgaa gatgaaagca cctcccaaca    28440

cccctttata aacccagggt ttatttcccc aaatggcttc acacaaagcc caaacggagt    28500

tcttacttta aaatgtttaa ccccactaac aaccacaggc ggatctctac agctaaaagt    28560

gggaggggga cttacagtgg atgacaccaa cggttttttg aaagaaaaca taagtgccac    28620

cacaccactc gttaagactg gtcactctat aggtttacca ctaggagccg gattgggaac    28680

gaatgaaaat aaactttgta tcaaattagg acaaggactt acattcaatt caaacaacat    28740

ttgcattgat gacaatatta acaccttatg gacaggagtc aaccccaccg aagccaactg    28800

tcaaatcatg aactccagtg aatctaatga ttgcaaatta attctaacac tagttaaaac    28860

tggagcacta gtcactgcat ttgtttatgt tataggagta tctaacaatt ttaatatgct    28920

aactacacac agaaatataa attttactgc agagctgttt ttcgattcta ctggtaattt    28980

actaactaga ctctcatccc tcaaaactcc acttaatcat aaatcaggac aaaacatggc    29040

tactggtgcc attactaatg ctaaaggttt catgcccagc acgactgcct atcctttcaa    29100

tgataattct agagaaaaag aaaactacat ttacggaact tgttactaca cagctagtga    29160

tcgcactgct tttcccattg acatatctgt catgcttaac cgaagagcaa taaatgacga    29220

gacatcatat tgtattcgta taacttggtc ctggaacaca ggagatgccc cagaggtgca    29280

aacctctgct acaaccctag tcacctcccc atttaccttt tactacatca gagaagacga    29340

ctgacaaata aagtttgcga tcgccaggcc caccatggga tggagctgta tcatcctctt    29400

cttggtagca acagctacag gtgtccactc ccaggtgcag ctgcagcagt ctggggctga    29460

actggcaaga cctggggcct cagtgaagat gtcctgcaag gcttctggct acacctttac    29520

taggtacacg atgcactggg taaaacagag gcctggacag ggtctggaat ggattggata    29580

cattaatcct agccgtggtt atactaatta caatcagaag ttcaaggaca aggccacatt    29640

gactacagac aaatcctcca gcacagccta catgcaactg agcagcctga catctgagga    29700

ctctgcagtc tattactgtg caagatatta tgatgatcat tactgccttg actactgggg    29760

ccaaggcacc actctcacag tctcctcagg tggcggtggc tcgggcggtg gtggatctgg    29820

tggcggcgga tctgatatcg tgctcactca gtctccagca atcatgtctg catctccagg    29880

ggagaaggtc accatgacct gcagtgccag ctcaagtgta agttacatga actggtacca    29940

gcagaagtca ggcacctccc ccaaaagatg gatttatgac acatccaaac tggcttctgg    30000

agtccctgct cacttcaggg gcagtgggtc tgggacctct tactctctca caatcagcgg    30060

catggaggct gaagatgctg ccacttatta ctgccagcag tggagtagta acccattcac    30120

gttcggctcg gggacaaagt tggaaataaa ccggggatcc gaacaaaaac tcatctcaga    30180

agaggatctg aatgctgtgg gccaggacac gcaggaggtc atcgtggtgc cacactcctt    30240

gccctttaag gtggtggtga tctcagccat cctggccctg gtggtgctca ccatcatctc    30300

ccttatcatc ctcatcatgc tttggcagaa gaagccacgt ggaagcggag ctactaactt    30360

cagcctgctg aagcaggctg gagacgtgga ggagaaccct ggacctggcc acacacggag    30420

gcagggaaca tcaccatcca agtgtccata cctcaatttc tttcagctct tggtgctggc    30480

tggtctttct cacttctgtt caggtgttat ccacgtgacc aaggaagtga aagaagtggc    30540

aacgctgtcc tgtggtcaca atgtttctgt tgaagagctg gcacaaactc gcatctactg    30600

gcaaaaggag aagaaaatgg tgctgactat gatgtctggg gacatgaata tatggcccga    30660

gtacaagaac cggaccatct ttgatatcac taataacctc tccattgtga tcctggctct    30720

gcgcccatct gacgagggca catacgagtg tgttgttctg aagtatgaaa aagacgcttt    30780

caagcgggaa cacctggctg aagtgacgtt atcagtcaaa gctgacttcc ctacacctag    30840

tatatctgac tttgaaattc caacttctaa tattagaagg ataatttgct caacctctgg    30900

aggttttcca gagcctcacc tctcctggtt ggaaaatgga gaagaattaa atgccatcaa    30960

cacaacagtt tcccaagatc ctgaaactga gctctatgct gttagcagca aactggattt    31020

caatatgaca accaaccaca gcttcatgtg tctcatcaag tatggacatt taagagtgaa    31080

tcagaccttc aactggaata caaccaagca agagcatttt cctgataacc tgctcccatc    31140

ctgggccatt accttaatct cagtaaatgg aatttttgtg atatgctgcc tgacctactg    31200

ctttgcccca agatgcagag agagaaggag gaatgagaga ttgagaaggg aaagtgtacg    31260

ccctgtagga agcggagagg gcagaggaag tctgctaaca tgcggtgacg tcgaggagaa    31320

tcctggacct caggtctcca ctgctgccct tgccgtcctc ctctgcacca tggctctctg    31380

caaccaggtc ctctctgcac cacttgctgc tgacacgccg accgcctgct gcttcagcta    31440

cacctcccga cagattccac agaatttcat agctgactac tttgagacga gcagccagtg    31500

ctccaagccc agtgtcatct tcctaaccaa gagaggccgg caggtctgtg ctgaccccag    31560

tgaggagtgg gtccagaaat acgtcagtga cctggagctg agtgcctaag ctagcttgac    31620

tgactgagat acagcgtacc ttcagctcac agacatgata agatacattg atgagtttgg    31680

acaaaccaca actagaatgc agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat    31740

tgctttattt gtaaccatta taagctgcaa taaacaagtt aacaacaaca attgcattca    31800

ttttatgttt caggttcagg gggaggtgtg ggaggttttt taaagcaagt aaaacctcta    31860

caaatgtggt agtcgtcagc tatcctgcag gaacttgttt atttgaaaat caattcacaa    31920

aatccgagta gttattttgc ctcccccttc ccatttaaca gaatacacca atctctcccc    31980

acgcacagct ttaaacattt ggataccatt agatatagac atggttttag attccacatt    32040

ccaaacagtt tcagagcgag ccaatctggg gtcagtgata gataaaaatc catcgggata    32100

gtcttttaaa gcgctttcac agtccaactg ctgcggatgc gactccggag tctggatcac    32160

ggtcatctgg aagaagaacg atgggaatca taatccgaaa acggtatcgg acgattgtgt    32220

ctcatcaaac ccacaagcag ccgctgtctg cgtcgctccg tgcgactgct gtttatggga    32280

tcagggtcca cagtgtcctg aagcatgatt ttaatagccc ttaacatcaa ctttctggtg    32340

cgatgcgcgc agcaacgcat tctgatttca ctcaaatctt tgcagtaggt acaacacatt    32400

attacaatat tgtttaataa accataatta aaagcgctcc agccaaaact catatctgat    32460

ataatcgccc ctgcatgacc atcataccaa agtttaatat aaattaaatg acgttccctc    32520

aaaaacacac tacccacata catgatctct tttggcatgt gcatattaac aatctgtctg    32580

taccatggac aacgttggtt aatcatgcaa cccaatataa ccttccggaa ccacactgcc    32640

aacaccgctc ccccagccat gcattgaagt gaaccctgct gattacaatg acaatgaaga    32700

acccaattct ctcgaccgtg aatcacttga gaatgaaaaa tatctatagt ggcacaacat    32760

agacataaat gcatgcatct tctcataatt tttaactcct caggatttag aaacatatcc    32820

cagggaatag gaagctcttg cagaacagta aagctggcag aacaaggaag accacgaaca    32880

caacttacac tatgcatagt catagtatca caatctggca acagcgggtg gtcttcagtc    32940

atagaagctc gggtttcatt ttcctcacaa cgtggtaact gggctctggt gtaagggtga    33000

tgtctggcgc atgatgtcga gcgtgcgcgc aaccttgtca taatggagtt gcttcctgac    33060

attctcgtat tttgtatagc aaaacgcggc cctggcagaa cacactcttc ttcgccttct    33120

atcctgccgc ttagcgtgtt ccgtgtgata gttcaagtac aaccacactc ttaagttggt    33180

caaaagaatg ctggcttcag ttgtaatcaa aactccatcg catctaatcg ttctgaggaa    33240

atcatccaag caatgcaact ggattgtgtt tcaagcagga gaggagaggg aagagacgga    33300

agaaccatgt taatttttat tccaaacgat ctcgcagtac ttcaaattgt agatcgcgca    33360

gatggcatct ctcgccccca ctgtgttggt gaaaaagcac agctagatca aaagaaatgc    33420

gattttcaag gtgctcaacg gtggcttcca gcaaagcctc cacgcgcaca tccaagaaca    33480

aaagaatacc aaaagaagga gcattttcta actcctcaat catcatatta cattcctgca    33540

ccattcccag ataattttca gctttccagc cttgaattat tcgtgtcagt tcttgtggta    33600

aatccaatcc acacattaca aacaggtccc ggagggcgcc ctccaccacc attcttaaac    33660

acaccctcat aatgacaaaa tatcttgctc ctgtgtcacc tgtagcgaat tgagaatggc    33720

aacatcaatt gacatgccct tggctctaag ttcttcttta agttctagtt gtaaaaactc    33780

tctcatatta tcaccaaact gcttagccag aagccccccg ggaacaagag caggggacgc    33840

tacagtgcag tacaagcgca gacctcccca attggctcca gcaaaaacaa gattggaata    33900

agcatattgg gaaccgccag taatatcatc gaagttgctg gaaatataat caggcagagt    33960

ttcttgtaaa aattgaataa aagaaaaatt tgccaaaaaa acattcaaaa cctctgggat    34020

gcaaatgcaa taggttaccg cgctgcgctc caacattgtt agttttgaat tagtctgcaa    34080

aaataaaaaa aaaaacaagc gtcatatcat agtagcctga cgaacagatg gataaatcag    34140

tctttccatc acaagacaag ccacagggtc tccagctcga ccctcgtaaa acctgtcatc    34200

atgattaaac aacagcaccg aaagttcctc gcggtgacca gcatgaataa ttcttgatga    34260

agcatacaat ccagacatgt tagcatcagt taacgagaaa aaacagccaa catagccttt    34320

gggtataatt atgcttaatc gtaagtatag caaagccacc cctcgcggat acaaagtaaa    34380

aggcacagga gaataaaaaa tataattatt tctctgctgc tgttcaggca acgtcgcccc    34440

cggtccctct aaatacacat acaaagcctc atcagccatg gcttaccaga caaagtacag    34500

cgggcacaca aagcacaagc tctaaagtga ctctccaacc tctccacaat atatatatac    34560

acaagcccta aactgacgta atgggagtaa agtgtaaaaa atcccgccaa acccaacaca    34620

caccccgaaa ctgcgtcacc agggaaaagt acagtttcac ttccgcaatc ccaacaggcg    34680

taacttcctc tttctcacgg tacgtgatat cccactaact tgcaacgtca ttttcccacg    34740

gtcgcaccgc cccttttagc cgttaacccc acagccaatc accacacgat ccacactttt    34800

taaaatcacc tcatttacat attggcacca ttccatctat aaggtatatt atatagatag    34860

a                                                                    34861


<210>  8
<211>  2535
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NG-500 transgene cassette

<400>  8
gcgatcgcca ggcccaccat gggatggagc tgtatcatcc tcttcttggt agcaacagct       60

acaggtgtcc actcccaggt gcagctgcag cagtctgggg ctgaactggc aagacctggg      120

gcctcagtga agatgtcctg caaggcttct ggctacacct ttactaggta cacgatgcac      180

tgggtaaaac agaggcctgg acagggtctg gaatggattg gatacattaa tcctagccgt      240

ggttatacta attacaatca gaagttcaag gacaaggcca cattgactac agacaaatcc      300

tccagcacag cctacatgca actgagcagc ctgacatctg aggactctgc agtctattac      360

tgtgcaagat attatgatga tcattactgc cttgactact ggggccaagg caccactctc      420

acagtctcct caggtggcgg tggctcgggc ggtggtggat ctggtggcgg cggatctgat      480

atcgtgctca ctcagtctcc agcaatcatg tctgcatctc caggggagaa ggtcaccatg      540

acctgcagtg ccagctcaag tgtaagttac atgaactggt accagcagaa gtcaggcacc      600

tcccccaaaa gatggattta tgacacatcc aaactggctt ctggagtccc tgctcacttc      660

aggggcagtg ggtctgggac ctcttactct ctcacaatca gcggcatgga ggctgaagat      720

gctgccactt attactgcca gcagtggagt agtaacccat tcacgttcgg ctcggggaca      780

aagttggaaa taaaccgggg atccgaacaa aaactcatct cagaagagga tctgaatgct      840

gtgggccagg acacgcagga ggtcatcgtg gtgccacact ccttgccctt taaggtggtg      900

gtgatctcag ccatcctggc cctggtggtg ctcaccatca tctcccttat catcctcatc      960

atgctttggc agaagaagcc acgtggaagc ggagctacta acttcagcct gctgaagcag     1020

gctggagacg tggaggagaa ccctggacct ggccacacac ggaggcaggg aacatcacca     1080

tccaagtgtc catacctcaa tttctttcag ctcttggtgc tggctggtct ttctcacttc     1140

tgttcaggtg ttatccacgt gaccaaggaa gtgaaagaag tggcaacgct gtcctgtggt     1200

cacaatgttt ctgttgaaga gctggcacaa actcgcatct actggcaaaa ggagaagaaa     1260

atggtgctga ctatgatgtc tggggacatg aatatatggc ccgagtacaa gaaccggacc     1320

atctttgata tcactaataa cctctccatt gtgatcctgg ctctgcgccc atctgacgag     1380

ggcacatacg agtgtgttgt tctgaagtat gaaaaagacg ctttcaagcg ggaacacctg     1440

gctgaagtga cgttatcagt caaagctgac ttccctacac ctagtatatc tgactttgaa     1500

attccaactt ctaatattag aaggataatt tgctcaacct ctggaggttt tccagagcct     1560

cacctctcct ggttggaaaa tggagaagaa ttaaatgcca tcaacacaac agtttcccaa     1620

gatcctgaaa ctgagctcta tgctgttagc agcaaactgg atttcaatat gacaaccaac     1680

cacagcttca tgtgtctcat caagtatgga catttaagag tgaatcagac cttcaactgg     1740

aatacaacca agcaagagca ttttcctgat aacctgctcc catcctgggc cattacctta     1800

atctcagtaa atggaatttt tgtgatatgc tgcctgacct actgctttgc cccaagatgc     1860

agagagagaa ggaggaatga gagattgaga agggaaagtg tacgccctgt aggaagcgga     1920

gagggcagag gaagtctgct aacatgcggt gacgtcgagg agaatcctgg acctcaggtc     1980

tccactgctg cccttgccgt cctcctctgc accatggctc tctgcaacca ggtcctctct     2040

gcaccacttg ctgctgacac gccgaccgcc tgctgcttca gctacacctc ccgacagatt     2100

ccacagaatt tcatagctga ctactttgag acgagcagcc agtgctccaa gcccagtgtc     2160

atcttcctaa ccaagagagg ccggcaggtc tgtgctgacc ccagtgagga gtgggtccag     2220

aaatacgtca gtgacctgga gctgagtgcc taagctagct tgactgactg agatacagcg     2280

taccttcagc tcacagacat gataagatac attgatgagt ttggacaaac cacaactaga     2340

atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt atttgtaacc     2400

attataagct gcaataaaca agttaacaac aacaattgca ttcattttat gtttcaggtt     2460

cagggggagg tgtgggaggt tttttaaagc aagtaaaacc tctacaaatg tggtagtcgt     2520

cagctatcct gcagg                                                      2535


<210>  9
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDGF TM Domain

<400>  9

Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu 
1               5                   10                  15      


Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu 
            20                  25                  30          


Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Pro Arg 
        35                  40                  45              


<210>  10
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Splice Acceptor Sequence

<400>  10
tttctctctt cagg                                                         14


<210>  11
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Splice Acceptor Sequence

<400>  11
tgctaatctt cctttctctc ttcagg                                            26


<210>  12
<211>  34522
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NG-348 Genome sequence

<400>  12
tctatctata taatatacct tatagatgga atggtgccaa tatgtaaatg aggtgatttt       60

aaaaagtgtg gatcgtgtgg tgattggctg tggggttaac ggctaaaagg ggcggtgcga      120

ccgtgggaaa atgacgtttt gtgggggtgg agtttttttg caagttgtcg cgggaaatgt      180

gacgcataaa aaggcttttt tctcacggaa ctacttagtt ttcccacggt atttaacagg      240

aaatgaggta gttttgaccg gatgcaagtg aaaattgttg attttcgcgc gaaaactgaa      300

tgaggaagtg tttttctgaa taatgtggta tttatggcag ggtggagtat ttgttcaggg      360

ccaggtagac tttgacccat tacgtggagg tttcgattac cgtgtttttt acctgaattt      420

ccgcgtaccg tgtcaaagtc ttctgttttt acgtaggtgt cagctgatcg ctagggtatt      480

tatacctcag ggtttgtgtc aagaggccac tcttgagtgc cagcgagaag agttttctcc      540

tctgcgccgg cagtttaata ataaaaaaat gagagatttg cgatttctgc ctcaggaaat      600

aatctctgct gagactggaa atgaaatatt ggagcttgtg gtgcacgccc tgatgggaga      660

cgatccggag ccacctgtgc agctttttga gcctcctacg cttcaggaac tgtatgattt      720

agaggtagag ggatcggagg attctaatga ggaagctgta aatggctttt ttaccgattc      780

tatgctttta gctgctaatg aagggttaga attagatccg cctttggaca cttttgatac      840

tccaggggta attgtggaaa gcggtacagg tgtaagaaaa ttacctgatt tgagttccgt      900

ggactgtgat ttgcactgct atgaagacgg gtttcctccg agtgatgagg aggaccatga      960

aaaggagcag tccatgcaga ctgcagcggg tgagggagtg aaggctgcca atgttggttt     1020

tcagttggat tgcccggagc ttcctggaca tggctgtaag tcttgtgaat ttcacaggaa     1080

aaatactgga gtaaaggaac tgttatgttc gctttgttat atgagaacgc actgccactt     1140

tatttacagt aagtgtgttt aagttaaaat ttaaaggaat atgctgtttt tcacatgtat     1200

attgagtgtg agttttgtgc ttcttattat aggtcctgtg tctgatgctg atgaatcacc     1260

atctcctgat tctactacct cacctcctga gattcaagca cctgttcctg tggacgtgcg     1320

caagcccatt cctgtgaagc ttaagcctgg gaaacgtcca gcagtggaaa aacttgagga     1380

cttgttacag ggtggggacg gacctttgga cttgagtaca cggaaacgtc caagacaata     1440

agtgttccat atccgtgttt acttaaggtg acgtcaatat ttgtgtgaca gtgcaatgta     1500

ataaaaatat gttaactgtt cactggtttt tattgctttt tgggcgggga ctcaggtata     1560

taagtagaag cagacctgtg tggttagctc ataggagctg gctttcatcc atggaggttt     1620

gggccatttt ggaagacctt aggaagacta ggcaactgtt agagaacgct tcggacggag     1680

tctccggttt ttggagattc tggttcgcta gtgaattagc tagggtagtt tttaggataa     1740

aacaggacta taaacaagaa tttgaaaagt tgttggtaga ttgcccagga ctttttgaag     1800

ctcttaattt gggccatcag gttcacttta aagaaaaagt tttatcagtt ttagactttt     1860

caaccccagg tagaactgct gctgctgtgg cttttcttac ttttatatta gataaatgga     1920

tcccgcagac tcatttcagc aggggatacg ttttggattt catagccaca gcattgtgga     1980

gaacatggaa ggttcgcaag atgaggacaa tcttaggtta ctggccagtg cagcctttgg     2040

gtgtagcggg aatcctgagg catccaccgg tcatgccagc ggttctggag gaggaacagc     2100

aagaggacaa cccgagagcc ggcctggacc ctccagtgga ggaggcggag tagctgactt     2160

gtctcctgaa ctgcaacggg tgcttactgg atctacgtcc actggacggg ataggggcgt     2220

taagagggag agggcatcta gtggtactga tgctagatct gagttggctt taagtttaat     2280

gagtcgcaga cgtcctgaaa ccatttggtg gcatgaggtt cagaaagagg gaagggatga     2340

agtttctgta ttgcaggaga aatattcact ggaacaggtg aaaacatgtt ggttggagcc     2400

tgaggatgat tgggaggtgg ccattaaaaa ttatgccaag atagctttga ggcctgataa     2460

acagtataag attactagac ggattaatat ccggaatgct tgttacatat ctggaaatgg     2520

ggctgaggtg gtaatagata ctcaagacaa ggcagttatt agatgctgca tgatggatat     2580

gtggcctggg gtagtcggta tggaagcagt aacttttgta aatgttaagt ttaggggaga     2640

tggttataat ggaatagtgt ttatggccaa taccaaactt atattgcatg gttgtagctt     2700

ttttggtttc aacaatacct gtgtagatgc ctggggacag gttagtgtac ggggatgtag     2760

tttctatgcg tgttggattg ccacagctgg cagaaccaag agtcaattgt ctctgaagaa     2820

atgcatattt caaagatgta acctgggcat tctgaatgaa ggcgaagcaa gggtccgcca     2880

ctgcgcttct acagatactg gatgttttat tttgattaag ggaaatgcca gcgtaaagca     2940

taacatgatt tgcggtgctt ccgatgagag gccttatcaa atgctcactt gtgctggtgg     3000

gcattgtaat atgctggcta ctgtgcatat tgtttcccat caacgcaaaa aatggcctgt     3060

ttttgatcac aatgtgatga cgaagtgtac catgcatgca ggtgggcgta gaggaatgtt     3120

tatgccttac cagtgtaaca tgaatcatgt gaaagtgttg ttggaaccag atgccttttc     3180

cagaatgagc ctaacaggaa tttttgacat gaacatgcaa atctggaaga tcctgaggta     3240

tgatgatacg agatcgaggg tacgcgcatg cgaatgcgga ggcaagcatg ccaggttcca     3300

gccggtgtgt gtagatgtga ctgaagatct cagaccggat catttggtta ttgcccgcac     3360

tggagcagag ttcggatcca gtggagaaga aactgactaa ggtgagtatt gggaaaactt     3420

tggggtggga ttttcagatg gacagattga gtaaaaattt gttttttctg tcttgcagct     3480

gtcatgagtg gaaacgcttc ttttaagggg ggagtcttca gcccttatct gacagggcgt     3540

ctcccatcct gggcaggagt tcgtcagaat gttatgggat ctactgtgga tggaagaccc     3600

gtccaacccg ccaattcttc aacgctgacc tatgctactt taagttcttc acctttggac     3660

gcagctgcag ctgccgccgc cgcttctgtt gccgctaaca ctgtgcttgg aatgggttac     3720

tatggaagca tcatggctaa ttccacttcc tctaataacc cttctaccct gactcaggac     3780

aagttacttg tccttttggc ccagctggag gctttgaccc aacgtctggg tgaactttct     3840

cagcaggtgg tcgagttgcg agtacaaact gagtctgctg tcggcacggc aaagtctaaa     3900

taaaaaaatc ccagaatcaa tgaataaata aacaagcttg ttgttgattt aaaatcaagt     3960

gtttttattt catttttcgc gcacggtatg ccctagacca ccgatctcta tcattgagaa     4020

ctcggtggat tttttccagg atcctataga ggtgggattg aatgtttaga tacatgggca     4080

ttaggccgtc tttggggtgg agatagctcc attgaaggga ttcatgctcc ggggtagtgt     4140

tgtaaatcac ccagtcataa caaggtcgca gtgcatggtg ttgcacaata tcttttagaa     4200

gtaggctgat tgccacagat aagcccttgg tgtaggtgtt tacaaaccgg ttgagctggg     4260

atgggtgcat tcggggtgaa attatgtgca ttttggattg gatttttaag ttggcaatat     4320

tgccgccaag atcccgtctt gggttcatgt tatgaaggac caccaagacg gtgtatccgg     4380

tacatttagg aaatttatcg tgcagcttgg atggaaaagc gtggaaaaat ttggagacac     4440

ccttgtgtcc tccaagattt tccatgcact catccatgat aatagcaatg gggccgtggg     4500

cagcggcgcg ggcaaacacg ttccgtgggt ctgacacatc atagttatgt tcctgagtta     4560

aatcatcata agccatttta atgaatttgg ggcggagagt accagattgg ggtatgaatg     4620

ttccttcggg ccccggagca tagttcccct cacagatttg catttcccaa gctttcagtt     4680

ccgagggtgg aatcatgtcc acctgggggg ctatgaaaaa caccgtttct ggggcggggg     4740

tgattaattg tgatgatagc aaatttctga gcaattgaga tttgccacat ccggtggggc     4800

cataaatgat tccgattacg ggttgcaggt ggtagtttag ggaacggcaa ctgccgtctt     4860

ctcgaagcaa gggggccacc tcgttcatca tttcccttac atgcatattt tcccgcacca     4920

aatccattag gaggcgctct cctcctagtg atagaagttc ttgtagtgag gaaaagtttt     4980

tcagcggttt cagaccgtca gccatgggca ttttggagag agtttgctgc aaaagttcta     5040

gtctgttcca cagttcagtg atgtgttcta tggcatctcg atccagcaga cctcctcgtt     5100

tcgcgggttt ggacggctcc tggaataggg tatgagacga tgggcgtcca gcgctgccag     5160

ggttcggtcc ttccagggtc tcagtgttcg agtcagggtt gtttccgtca cagtgaaggg     5220

gtgtgcgcct gcttgggcgc ttgccagggt gcgcttcaga ctcatcctgc tggtcgaaaa     5280

cttctgtcgc ttggcgccct gtatgtcggc caagtagcag tttaccatga gttcgtagtt     5340

gagcgcctcg gctgcgtggc ctttggcgcg gagcttacct ttggaagttt tcttgcatac     5400

cgggcagtat aggcatttca gcgcatacaa cttgggcgca aggaaaacgg attctgggga     5460

gtatgcatct gcgccgcagg aggcgcaaac agtttcacat tccaccagcc aggttaaatc     5520

cggttcattg gggtcaaaaa caagttttcc gccatatttt ttgatgcgtt tcttaccttt     5580

ggtctccatg agttcgtgtc ctcgttgagt gacaaacagg ctgtccgtgt ccccgtagac     5640

tgattttaca ggcctcttct ccagtggagt gcctcggtct tcttcgtaca ggaactctga     5700

ccactctgat acaaaggcgc gcgtccaggc cagcacaaag gaggctatgt gggaggggta     5760

gcgatcgttg tcaaccaggg ggtccacctt ttccaaagta tgcaaacaca tgtcaccctc     5820

ttcaacatcc aggaatgtga ttggcttgta ggtgtatttc acgtgacctg gggtccccgc     5880

tgggggggta taaaaggggg cggttctttg ctcttcctca ctgtcttccg gatcgctgtc     5940

caggaacgtc agctgttggg gtaggtattc cctctcgaag gcgggcatga cctctgcact     6000

caggttgtca gtttctaaga acgaggagga tttgatattg acagtgccgg ttgagatgcc     6060

tttcatgagg ttttcgtcca tctggtcaga aaacacaatt tttttattgt caagtttggt     6120

ggcaaatgat ccatacaggg cgttggataa aagtttggca atggatcgca tggtttggtt     6180

cttttccttg tccgcgcgct ctttggcggc gatgttgagt tggacatact cgcgtgccag     6240

gcacttccat tcggggaaga tagttgttaa ttcatctggc acgattctca cttgccaccc     6300

tcgattatgc aaggtaatta aatccacact ggtggccacc tcgcctcgaa ggggttcatt     6360

ggtccaacag agcctacctc ctttcctaga acagaaaggg ggaagtgggt ctagcataag     6420

ttcatcggga gggtctgcat ccatggtaaa gattcccgga agtaaatcct tatcaaaata     6480

gctgatggga gtggggtcat ctaaggccat ttgccattct cgagctgcca gtgcgcgctc     6540

atatgggtta aggggactgc cccatggcat gggatgggtg agtgcagagg catacatgcc     6600

acagatgtca tagacgtaga tgggatcctc aaagatgcct atgtaggttg gatagcatcg     6660

cccccctctg atacttgctc gcacatagtc atatagttca tgtgatggcg ctagcagccc     6720

cggacccaag ttggtgcgat tgggtttttc tgttctgtag acgatctggc gaaagatggc     6780

gtgagaattg gaagagatgg tgggtctttg aaaaatgttg aaatgggcat gaggtagacc     6840

tacagagtct ctgacaaagt gggcataaga ttcttgaagc ttggttacca gttcggcggt     6900

gacaagtacg tctagggcgc agtagtcaag tgtttcttga atgatgtcat aacctggttg     6960

gtttttcttt tcccacagtt cgcggttgag aaggtattct tcgcgatcct tccagtactc     7020

ttctagcgga aacccgtctt tgtctgcacg gtaagatcct agcatgtaga actgattaac     7080

tgccttgtaa gggcagcagc ccttctctac gggtagagag tatgcttgag cagcttttcg     7140

tagcgaagcg tgagtaaggg caaaggtgtc tctgaccatg actttgagga attggtattt     7200

gaagtcgatg tcgtcacagg ctccctgttc ccagagttgg aagtctaccc gtttcttgta     7260

ggcggggttg ggcaaagcga aagtaacatc attgaagaga atcttgccgg ccctgggcat     7320

gaaattgcga gtgatgcgaa aaggctgtgg tacttccgct cggttattga taacctgggc     7380

agctaggacg atctcgtcga aaccgttgat gttgtgtcct acgatgtata attctatgaa     7440

acgcggcgtg cctctgacgt gaggtagctt actgagctca tcaaaggtta ggtctgtggg     7500

gtcagataag gcgtagtgtt cgagagccca ttcgtgcagg tgaggattcg ctttaaggaa     7560

ggaggaccag aggtccactg ccagtgctgt ttgtaactgg tcccggtact gacgaaaatg     7620

ccgtccgact gccatttttt ctggggtgac gcaatagaag gtttgggggt cctgccgcca     7680

gcgatcccac ttgagtttta tggcgaggtc ataggcgatg ttgacgagcc gctggtctcc     7740

agagagtttc atgaccagca tgaaggggat tagctgcttg ccaaaggacc ccatccaggt     7800

gtaggtttcc acatcgtagg tgagaaagag cctttctgtg cgaggatgag agccaatcgg     7860

gaagaactgg atctcctgcc accagttgga ggaatggctg ttgatgtgat ggaagtagaa     7920

ctccctgcga cgcgccgagc attcatgctt gtgcttgtac agacggccgc agtagtcgca     7980

gcgttgcacg ggttgtatct cgtgaatgag ttgtacctgg cttcccttga cgagaaattt     8040

cagtgggaag ccgaggcctg gcgattgtat ctcgtgcttt actatgttgt ctgcatcggc     8100

ctgttcatct tctgtctcga tggtggtcat gctgacgagc cctcgcggga ggcaagtcca     8160

gacctcggcg cggcaggggc ggagctcgag gacgagagcg cgcaggctgg agctgtccag     8220

ggtcctgaga cgctgcggac tcaggttagt aggcagtgtc aggagattaa cttgcatgat     8280

cttttggagg gcgtgcggga ggttcagata gtacttgatc tcaacgggtc cgttggtgga     8340

gatgtcgatg gcttgcaggg ttccgtgtcc cttgggcgct accaccgtgc ccttgttttt     8400

cattttggac ggcggtggct ctgttgcttc ttgcatgttt agaagcggtg tcgagggcgc     8460

gcaccgggcg gcaggggcgg ctcgggaccc ggcggcatgg ctggcagtgg tacgtcggcg     8520

ccgcgcgcgg gtaggttctg gtactgcgcc ctgagaagac tcgcatgcgc gacgacgcgg     8580

cggttgacat cctggatctg acgcctctgg gtgaaagcta ccggccccgt gagcttgaac     8640

ctgaaagaga gttcaacaga atcaatctcg gtatcgttga cggcggcttg cctaaggatt     8700

tcttgcacgt caccagagtt gtcctggtag gcgatctccg ccatgaactg ctcgatctct     8760

tcctcttgaa gatctccgcg gcccgctctc tcgacggtgg ccgcgaggtc gttggagatg     8820

cgcccaatga gttgagagaa tgcattcatg cccgcctcgt tccagacgcg gctgtagacc     8880

acggccccca cgggatctct cgcgcgcatg accacctggg cgaggttgag ctccacgtgg     8940

cgggtgaaga ccgcatagtt gcataggcgc tggaaaaggt agttgagtgt ggtggcgatg     9000

tgctcggtga cgaagaaata catgatccat cgtctcagcg gcatctcgct gacatcgccc     9060

agagcttcca agcgctccat ggcctcgtag aagtccacgg caaaattaaa aaactgggag     9120

tttcgcgcgg acacggtcaa ctcctcttcc agaagacgga taagttcggc gatggtggtg     9180

cgcacctcgc gctcgaaagc ccctgggatt tcttcctcaa tctcttcttc ttccactaac     9240

atctcttcct cttcaggtgg ggctgcagga ggagggggaa cgcggcgacg ccggcggcgc     9300

acgggcagac ggtcgatgaa tctttcaatg acctctccgc ggcggcggcg catggtttca     9360

gtgacggcgc ggccgttctc gcgcggtcgc agagtaaaaa caccgccgcg catctcctta     9420

aagtggtgac tgggaggttc tccgtttggg agggagaggg cgctgattat acattttatt     9480

aattggcccg tagggactgc acgcagagat ctgatcgtgt caagatccac gggatctgaa     9540

aacctttcga cgaaagcgtc taaccagtca cagtcacaag gtaggctgag tacggcttct     9600

tgtgggcggg ggtggttatg tgttcggtct gggtcttctg tttcttcttc atctcgggaa     9660

ggtgagacga tgctgctggt gatgaaatta aagtaggcag ttctaagacg gcggatggtg     9720

gcgaggagca ccaggtcttt gggtccggct tgctggatac gcaggcgatt ggccattccc     9780

caagcattat cctgacatct agcaagatct ttgtagtagt cttgcatgag ccgttctacg     9840

ggcacttctt cctcacccgt tctgccatgc atacgtgtga gtccaaatcc gcgcattggt     9900

tgtaccagtg ccaagtcagc tacgactctt tcggcgagga tggcttgctg tacttgggta     9960

agggtggctt gaaagtcatc aaaatccaca aagcggtggt aagctcctgt attaatggtg    10020

taagcacagt tggccatgac tgaccagtta actgtctggt gaccagggcg cacgagctcg    10080

gtgtatttaa ggcgcgaata ggcgcgggtg tcaaagatgt aatcgttgca ggtgcgcacc    10140

agatactggt accctataag aaaatgcggc ggtggttggc ggtagagagg ccatcgttct    10200

gtagctggag cgccaggggc gaggtcttcc aacataaggc ggtgatagcc gtagatgtac    10260

ctggacatcc aggtgattcc tgcggcggta gtagaagccc gaggaaactc gcgtacgcgg    10320

ttccaaatgt tgcgtagcgg catgaagtag ttcattgtag gcacggtttg accagtgagg    10380

cgcgcgcagt cattgatgct ctatagacac ggagaaaatg aaagcgttca gcgactcgac    10440

tccgtagcct ggaggaacgt gaacgggttg ggtcgcggtg taccccggtt cgagacttgt    10500

actcgagccg gccggagccg cggctaacgt ggtattggca ctcccgtctc gacccagcct    10560

acaaaaatcc aggatacgga atcgagtcgt tttgctggtt tccgaatggc agggaagtga    10620

gtcctatttt ttttttttgc cgctcagatg catcccgtgc tgcgacagat gcgcccccaa    10680

caacagcccc cctcgcagca gcagcagcag caatcacaaa aggctgtccc tgcaactact    10740

gcaactgccg ccgtgagcgg tgcgggacag cccgcctatg atctggactt ggaagagggc    10800

gaaggactgg cacgtctagg tgcgccttca cccgagcggc atccgcgagt tcaactgaaa    10860

aaagattctc gcgaggcgta tgtgccccaa cagaacctat ttagagacag aagcggcgag    10920

gagccggagg agatgcgagc ttcccgcttt aacgcgggtc gtgagctgcg tcacggtttg    10980

gaccgaagac gagtgttgcg ggacgaggat ttcgaagttg atgaaatgac agggatcagt    11040

cctgccaggg cacacgtggc tgcagccaac cttgtatcgg cttacgagca gacagtaaag    11100

gaagagcgta acttccaaaa gtcttttaat aatcatgtgc gaaccctgat tgcccgcgaa    11160

gaagttaccc ttggtttgat gcatttgtgg gatttgatgg aagctatcat tcagaaccct    11220

actagcaaac ctctgaccgc ccagctgttt ctggtggtgc aacacagcag agacaatgag    11280

gctttcagag aggcgctgct gaacatcacc gaacccgagg ggagatggtt gtatgatctt    11340

atcaacattc tacagagtat catagtgcag gagcggagcc tgggcctggc cgagaaggtg    11400

gctgccatca attactcggt tttgagcttg ggaaaatatt acgctcgcaa aatctacaag    11460

actccatacg ttcccataga caaggaggtg aagatagatg ggttctacat gcgcatgacg    11520

ctcaaggtct tgaccctgag cgatgatctt ggggtgtatc gcaatgacag aatgcatcgc    11580

gcggttagcg ccagcaggag gcgcgagtta agcgacaggg aactgatgca cagtttgcaa    11640

agagctctga ctggagctgg aaccgagggt gagaattact tcgacatggg agctgacttg    11700

cagtggcagc ctagtcgcag ggctctgagc gccgcgacgg caggatgtga gcttccttac    11760

atagaagagg cggatgaagg cgaggaggaa gagggcgagt acttggaaga ctgatggcac    11820

aacccgtgtt ttttgctaga tggaacagca agcaccggat cccgcaatgc gggcggcgct    11880

gcagagccag ccgtccggca ttaactcctc ggacgattgg acccaggcca tgcaacgtat    11940

catggcgttg acgactcgca accccgaagc ctttagacag caaccccagg ccaaccgtct    12000

atcggccatc atggaagctg tagtgccttc ccgctctaat cccactcatg agaaggtcct    12060

ggccatcgtg aacgcgttgg tggagaacaa agctattcgt ccagatgagg ccggactggt    12120

atacaacgct ctcttagaac gcgtggctcg ctacaacagt agcaatgtgc aaaccaattt    12180

ggaccgtatg ataacagatg tacgcgaagc cgtgtctcag cgcgaaaggt tccagcgtga    12240

tgccaacctg ggttcgctgg tggcgttaaa tgctttcttg agtactcagc ctgctaatgt    12300

gccgcgtggt caacaggatt atactaactt tttaagtgct ttgagactga tggtatcaga    12360

agtacctcag agcgaagtgt atcagtccgg tcctgattac ttctttcaga ctagcagaca    12420

gggcttgcag acggtaaatc tgagccaagc ttttaaaaac cttaaaggtt tgtggggagt    12480

gcatgccccg gtaggagaaa gagcaaccgt gtctagcttg ttaactccga actcccgcct    12540

attattactg ttggtagctc ctttcaccga cagcggtagc atcgaccgta attcctattt    12600

gggttaccta ctaaacctgt atcgcgaagc catagggcaa agtcaggtgg acgagcagac    12660

ctatcaagaa attacccaag tcagtcgcgc tttgggacag gaagacactg gcagtttgga    12720

agccactctg aacttcttgc ttaccaatcg gtctcaaaag atccctcctc aatatgctct    12780

tactgcggag gaggagagga tccttagata tgtgcagcag agcgtgggat tgtttctgat    12840

gcaagagggg gcaactccga ctgcagcact ggacatgaca gcgcgaaata tggagcccag    12900

catgtatgcc agtaaccgac ctttcattaa caaactgctg gactacttgc acagagctgc    12960

cgctatgaac tctgattatt tcaccaatgc catcttaaac ccgcactggc tgcccccacc    13020

tggtttctac acgggcgaat atgacatgcc cgaccctaat gacggatttc tgtgggacga    13080

cgtggacagc gatgtttttt cacctctttc tgatcatcgc acgtggaaaa aggaaggcgg    13140

cgatagaatg cattcttctg catcgctgtc cggggtcatg ggtgctaccg cggctgagcc    13200

cgagtctgca agtccttttc ctagtctacc cttttctcta cacagtgtac gtagcagcga    13260

agtgggtaga ataagtcgcc cgagtttaat gggcgaagag gagtatctaa acgattcctt    13320

gctcagaccg gcaagagaaa aaaatttccc aaacaatgga atagaaagtt tggtggataa    13380

aatgagtaga tggaagactt atgctcagga tcacagagac gagcctggga tcatggggat    13440

tacaagtaga gcgagccgta gacgccagcg ccatgacaga cagaggggtc ttgtgtggga    13500

cgatgaggat tcggccgatg atagcagcgt gctggacttg ggtgggagag gaaggggcaa    13560

cccgtttgct catttgcgcc ctcgcttggg tggtatgttg taaaaaaaaa taaaaaaaaa    13620

actcaccaag gccatggcga cgagcgtacg ttcgttcttc tttattatct gtgtctagta    13680

taatgaggcg agtcgtgcta ggcggagcgg tggtgtatcc ggagggtcct cctccttcgt    13740

acgagagcgt gatgcagcag cagcaggcga cggcggtgat gcaatcccca ctggaggctc    13800

cctttgtgcc tccgcgatac ctggcaccta cggagggcag aaacagcatt cgttattcgg    13860

aactggcacc tcagtacgat accaccaggt tgtatctggt ggacaacaag tcggcggaca    13920

ttgcttctct gaactatcag aatgaccaca gcaacttctt gaccacggtg gtgcaaaaca    13980

atgactttac ccctacggaa gccagcaccc agaccattaa ctttgatgaa cgatcgcggt    14040

ggggcggtca gctaaagacc atcatgcata ctaacatgcc aaacgtgaac gagtatatgt    14100

ttagtaacaa gttcaaagcg cgtgtgatgg tgtccagaaa acctcccgac ggtgctgcag    14160

ttggggatac ttatgatcac aagcaggata ttttgaaata tgagtggttc gagtttactt    14220

tgccagaagg caacttttca gttactatga ctattgattt gatgaacaat gccatcatag    14280

ataattactt gaaagtgggt agacagaatg gagtgcttga aagtgacatt ggtgttaagt    14340

tcgacaccag gaacttcaag ctgggatggg atcccgaaac caagttgatc atgcctggag    14400

tgtatacgta tgaagccttc catcctgaca ttgtcttact gcctggctgc ggagtggatt    14460

ttaccgagag tcgtttgagc aaccttcttg gtatcagaaa aaaacagcca tttcaagagg    14520

gttttaagat tttgtatgaa gatttagaag gtggtaatat tccggccctc ttggatgtag    14580

atgcctatga gaacagtaag aaagaacaaa aagccaaaat agaagctgct acagctgctg    14640

cagaagctaa ggcaaacata gttgccagcg actctacaag ggttgctaac gctggagagg    14700

tcagaggaga caattttgcg ccaacacctg ttccgactgc agaatcatta ttggccgatg    14760

tgtctgaagg aacggacgtg aaactcacta ttcaacctgt agaaaaagat agtaagaata    14820

gaagctataa tgtgttggaa gacaaaatca acacagccta tcgcagttgg tatctttcgt    14880

acaattatgg cgatcccgaa aaaggagtgc gttcctggac attgctcacc acctcagatg    14940

tcacctgcgg agcagagcag gtctactggt cgcttccaga catgatgaag gatcctgtca    15000

ctttccgctc cactagacaa gtcagtaact accctgtggt gggtgcagag cttatgcccg    15060

tcttctcaaa gagcttctac aacgaacaag ctgtgtactc ccagcagctc cgccagtcca    15120

cctcgcttac gcacgtcttc aaccgctttc ctgagaacca gattttaatc cgtccgccgg    15180

cgcccaccat taccaccgtc agtgaaaacg ttcctgctct cacagatcac gggaccctgc    15240

cgttgcgcag cagtatccgg ggagtccaac gtgtgaccgt tactgacgcc agacgccgca    15300

cctgtcccta cgtgtacaag gcactgggca tagtcgcacc gcgcgtcctt tcaagccgca    15360

ctttctaaaa aaaaaaaaaa tgtccattct tatctcgccc agtaataaca ccggttgggg    15420

tctgcgcgct ccaagcaaga tgtacggagg cgcacgcaaa cgttctaccc aacatcctgt    15480

ccgtgttcgc ggacattttc gcgctccatg gggcgccctc aagggccgca ctcgcgttcg    15540

aaccaccgtc gatgatgtaa tcgatcaggt ggttgccgac gcccgtaatt atactcctac    15600

tgcgcctaca tctactgtgg atgcagttat tgacagtgta gtggctgacg ctcgcaacta    15660

tgctcgacgt aagagccggc gaaggcgcat tgccagacgc caccgagcta ccactgccat    15720

gcgagccgca agagctctgc tacgaagagc tagacgcgtg gggcgaagag ccatgcttag    15780

ggcggccaga cgtgcagctt cgggcgccag cgccggcagg tcccgcaggc aagcagccgc    15840

tgtcgcagcg gcgactattg ccgacatggc ccaatcgcga agaggcaatg tatactgggt    15900

gcgtgacgct gccaccggtc aacgtgtacc cgtgcgcacc cgtccccctc gcacttagaa    15960

gatactgagc agtctccgat gttgtgtccc agcggcgagg atgtccaagc gcaaatacaa    16020

ggaagaaatg ctgcaggtta tcgcacctga agtctacggc caaccgttga aggatgaaaa    16080

aaaaccccgc aaaatcaagc gggttaaaaa ggacaaaaaa gaagaggaag atggcgatga    16140

tgggctggcg gagtttgtgc gcgagtttgc cccacggcga cgcgtgcaat ggcgtgggcg    16200

caaagttcga catgtgttga gacctggaac ttcggtggtc tttacacccg gcgagcgttc    16260

aagcgctact tttaagcgtt cctatgatga ggtgtacggg gatgatgata ttcttgagca    16320

ggcggctgac cgattaggcg agtttgctta tggcaagcgt agtagaataa cttccaagga    16380

tgagacagtg tcgataccct tggatcatgg aaatcccacc cctagtctta aaccggtcac    16440

tttgcagcaa gtgttacccg taactccgcg aacaggtgtt aaacgcgaag gtgaagattt    16500

gtatcccact atgcaactga tggtacccaa acgccagaag ttggaggacg ttttggagaa    16560

agtaaaagtg gatccagata ttcaacctga ggttaaagtg agacccatta agcaggtagc    16620

gcctggtctg ggggtacaaa ctgtagacat taagattccc actgaaagta tggaagtgca    16680

aactgaaccc gcaaagccta ctgccacctc cactgaagtg caaacggatc catggatgcc    16740

catgcctatt acaactgacg ccgccggtcc cactcgaaga tcccgacgaa agtacggtcc    16800

agcaagtctg ttgatgccca attatgttgt acacccatct attattccta ctcctggtta    16860

ccgaggcact cgctactatc gcagccgaaa cagtacctcc cgccgtcgcc gcaagacacc    16920

tgcaaatcgc agtcgtcgcc gtagacgcac aagcaaaccg actcccggcg ccctggtgcg    16980

gcaagtgtac cgcaatggta gtgcggaacc tttgacactg ccgcgtgcgc gttaccatcc    17040

gagtatcatc acttaatcaa tgttgccgct gcctccttgc agatatggcc ctcacttgtc    17100

gccttcgcgt tcccatcact ggttaccgag gaagaaactc gcgccgtaga agagggatgt    17160

tgggacgcgg aatgcgacgc tacaggcgac ggcgtgctat ccgcaagcaa ttgcggggtg    17220

gttttttacc agccttaatt ccaattatcg ctgctgcaat tggcgcgata ccaggcatag    17280

cttccgtggc ggttcaggcc tcgcaacgac attgacattg gaaaaaaacg tataaataaa    17340

aaaaaaaaaa tacaatggac tctgacactc ctggtcctgt gactatgttt tcttagagat    17400

ggaagacatc aatttttcat ccttggctcc gcgacacggc acgaagccgt acatgggcac    17460

ctggagcgac atcggcacga gccaactgaa cgggggcgcc ttcaattgga gcagtatctg    17520

gagcgggctt aaaaattttg gctcaaccat aaaaacatac gggaacaaag cttggaacag    17580

cagtacagga caggcgctta gaaataaact taaagaccag aacttccaac aaaaagtagt    17640

cgatgggata gcttccggca tcaatggagt ggtagatttg gctaaccagg ctgtgcagaa    17700

aaagataaac agtcgtttgg acccgccgcc agcaacccca ggtgaaatgc aagtggagga    17760

agaaattcct ccgccagaaa aacgaggcga caagcgtccg cgtcccgatt tggaagagac    17820

gctggtgacg cgcgtagatg aaccgccttc ttatgaggaa gcaacgaagc ttggaatgcc    17880

caccactaga ccgatagccc caatggccac cggggtgatg aaaccttctc agttgcatcg    17940

acccgtcacc ttggatttgc cccctccccc tgctgctact gctgtacccg cttctaagcc    18000

tgtcgctgcc ccgaaaccag tcgccgtagc caggtcacgt cccgggggcg ctcctcgtcc    18060

aaatgcgcac tggcaaaata ctctgaacag catcgtgggt ctaggcgtgc aaagtgtaaa    18120

acgccgtcgc tgcttttaat taaatatgga gtagcgctta acttgcctat ctgtgtatat    18180

gtgtcattac acgccgtcac agcagcagag gaaaaaagga agaggtcgtg cgtcgacgct    18240

gagttacttt caagatggcc accccatcga tgctgcccca atgggcatac atgcacatcg    18300

ccggacagga tgcttcggag tacctgagtc cgggtctggt gcagttcgcc cgcgccacag    18360

acacctactt caatctggga aataagttta gaaatcccac cgtagcgccg acccacgatg    18420

tgaccaccga ccgtagccag cggctcatgt tgcgcttcgt gcccgttgac cgggaggaca    18480

atacatactc ttacaaagtg cggtacaccc tggccgtggg cgacaacaga gtgctggata    18540

tggccagcac gttctttgac attaggggtg tgttggacag aggtcccagt ttcaaaccct    18600

attctggtac ggcttacaac tccctggctc ctaaaggcgc tccaaataca tctcagtgga    18660

ttgcagaagg tgtaaaaaat acaactggtg aggaacacgt aacagaagag gaaaccaata    18720

ctactactta cacttttggc aatgctcctg taaaagctga agctgaaatt acaaaagaag    18780

gactcccagt aggtttggaa gtttcagatg aagaaagtaa accgatttat gctgataaaa    18840

catatcagcc agaacctcag ctgggagatg aaacttggac tgaccttgat ggaaaaaccg    18900

aaaagtatgg aggcagggct ctcaaacccg atactaagat gaaaccatgc tacgggtcct    18960

ttgccaaacc tactaatgtg aaaggcggtc aggcaaaaca aaaaacaacg gagcagccaa    19020

atcagaaagt cgaatatgat atcgacatgg agttttttga tgcggcatcg cagaaaacaa    19080

acttaagtcc taaaattgtc atgtatgcag aaaatgtaaa tttggaaact ccagacactc    19140

atgtagtgta caaacctgga acagaagaca caagttccga agctaatttg ggacaacaat    19200

ctatgcccaa cagacccaac tacattggct tcagagataa ctttattgga cttatgtact    19260

ataacagtac tggtaacatg ggggtgctgg ctggtcaagc gtctcagtta aatgcagtgg    19320

ttgacttgca ggacagaaac acagaacttt cttaccaact cttgcttgac tctctgggcg    19380

acagaaccag atactttagc atgtggaatc aggctgtgga cagttatgat cctgatgtac    19440

gtgttattga aaatcatggt gtggaagatg aacttcccaa ctactgtttt ccactggacg    19500

gcataggtgt tccaacaacc agttacaaat caatagttcc aaatggagac aatgcgccta    19560

attggaagga acctgaagta aatggaacaa gtgagatcgg acagggtaat ttgtttgcca    19620

tggaaattaa ccttcaagcc aatctatggc gaagtttcct ttattccaat gtggctctat    19680

atctcccaga ctcgtacaaa tacaccccgt ccaatgtcac tcttccagaa aacaaaaaca    19740

cctacgacta catgaacggg cgggtggtgc cgccatctct agtagacacc tatgtgaaca    19800

ttggtgccag gtggtctctg gatgccatgg acaatgtcaa cccattcaac caccaccgta    19860

acgctggctt gcgttaccga tccatgcttc tgggtaacgg acgttatgtg cctttccaca    19920

tacaagtgcc tcaaaaattc ttcgctgtta aaaacctgct gcttctccca ggctcctaca    19980

cttatgagtg gaactttagg aaggatgtga acatggttct acagagttcc ctcggtaacg    20040

acctgcgggt agatggcgcc agcatcagtt tcacgagcat caacctctat gctacttttt    20100

tccccatggc tcacaacacc gcttccaccc ttgaagccat gctgcggaat gacaccaatg    20160

atcagtcatt caacgactac ctatctgcag ctaacatgct ctaccccatt cctgccaatg    20220

caaccaatat tcccatttcc attccttctc gcaactgggc ggctttcaga ggctggtcat    20280

ttaccagact gaaaaccaaa gaaactccct ctttggggtc tggatttgac ccctactttg    20340

tctattctgg ttctattccc tacctggatg gtaccttcta cctgaaccac acttttaaga    20400

aggtttccat catgtttgac tcttcagtga gctggcctgg aaatgacagg ttactatctc    20460

ctaacgaatt tgaaataaag cgcactgtgg atggcgaagg ctacaacgta gcccaatgca    20520

acatgaccaa agactggttc ttggtacaga tgctcgccaa ctacaacatc ggctatcagg    20580

gcttctacat tccagaagga tacaaagatc gcatgtattc atttttcaga aacttccagc    20640

ccatgagcag gcaggtggtt gatgaggtca attacaaaga cttcaaggcc gtcgccatac    20700

cctaccaaca caacaactct ggctttgtgg gttacatggc tccgaccatg cgccaaggtc    20760

aaccctatcc cgctaactat ccctatccac tcattggaac aactgccgta aatagtgtta    20820

cgcagaaaaa gttcttgtgt gacagaacca tgtggcgcat accgttctcg agcaacttca    20880

tgtctatggg ggcccttaca gacttgggac agaatatgct ctatgccaac tcagctcatg    20940

ctctggacat gacctttgag gtggatccca tggatgagcc caccctgctt tatcttctct    21000

tcgaagtttt cgacgtggtc agagtgcatc agccacaccg cggcatcatc gaggcagtct    21060

acctgcgtac accgttctcg gccggtaacg ctaccacgta agaagcttct tgcttcttgc    21120

aaatagcagc tgcaaccatg gcctgcggat cccaaaacgg ctccagcgag caagagctca    21180

gagccattgt ccaagacctg ggttgcggac cctatttttt gggaacctac gataagcgct    21240

tcccggggtt catggccccc gataagctcg cctgtgccat tgtaaatacg gccggacgtg    21300

agacgggggg agagcactgg ttggctttcg gttggaaccc acgttctaac acctgctacc    21360

tttttgatcc ttttggattc tcggatgatc gtctcaaaca gatttaccag tttgaatatg    21420

agggtctcct gcgccgcagc gctcttgcta ccaaggaccg ctgtattacg ctggaaaaat    21480

ctacccagac cgtgcagggt ccccgttctg ccgcctgcgg acttttctgc tgcatgttcc    21540

ttcacgcctt tgtgcactgg cctgaccgtc ccatggacgg aaaccccacc atgaaattgc    21600

taactggagt gccaaacaac atgcttcatt ctcctaaagt ccagcccacc ctgtgtgaca    21660

atcaaaaagc actctaccat tttcttaata cccattcgcc ttattttcgc tcccatcgta    21720

cacacatcga aagggccact gcgttcgacc gtatggatgt tcaataatga ctcatgtaaa    21780

caacgtgttc aataaacatc actttatttt tttacatgta tcaaggctct gcattactta    21840

tttatttaca agtcgaatgg gttctgacga gaatcagaat gacccgcagg cagtgatacg    21900

ttgcggaact gatacttggg ttgccacttg aattcgggaa tcaccaactt gggaaccggt    21960

atatcgggca ggatgtcact ccacagcttt ctggtcagct gcaaagctcc aagcaggtca    22020

ggagccgaaa tcttgaaatc acaattagga ccagtgcttt gagcgcgaga gttgcggtac    22080

accggattgc agcactgaaa caccatcagc gacggatgtc tcacgcttgc cagcacggtg    22140

ggatctgcaa tcatgcccac atccagatct tcagcattgg caatgctgaa cggggtcatc    22200

ttgcaggtct gcctacccat ggcgggcacc caattaggct tgtggttgca atcgcagtgc    22260

agggggatca gtatcatctt ggcctgatcc tgtctgattc ctggatacac ggctctcatg    22320

aaagcatcat attgcttgaa agcctgctgg gctttactac cctcggtata aaacatcccg    22380

caggacctgc tcgaaaactg gttagctgca cagccggcat cattcacaca gcagcgggcg    22440

tcattgttag ctatttgcac cacacttctg ccccagcggt tttgggtgat tttggttcgc    22500

tcgggattct cctttaaggc tcgttgtccg ttctcgctgg ccacatccat ctcgataatc    22560

tgctccttct gaatcataat attgccatgc aggcacttca gcttgccctc ataatcattg    22620

cagccatgag gccacaacgc acagcctgta cattcccaat tatggtgggc gatctgagaa    22680

aaagaatgta tcattccctg cagaaatctt cccatcatcg tgctcagtgt cttgtgacta    22740

gtgaaagtta actggatgcc tcggtgctcc tcgtttacgt actggtgaca gatgcgcttg    22800

tattgttcgt gttgctcagg cattagttta aaagaggttc taagttcgtt atccagcctg    22860

tacttctcca tcagcagaca catcacttcc atgcctttct cccaagcaga caccaggggc    22920

aagctaatcg gattcttaac agtgcaggca gcagctcctt tagccagagg gtcatcttta    22980

gcgatcttct caatgcttct tttgccatcc ttctcaacga tgcgcacggg cgggtagctg    23040

aaacccactg ctacaagttg cgcctcttct ctttcttctt cgctgtcttg actgatgtct    23100

tgcatgggga tatgtttggt cttccttggc ttctttttgg ggggtatcgg aggaggagga    23160

ctgtcgctcc gttccggaga cagggaggat tgtgacgttt cgctcaccat taccaactga    23220

ctgtcggtag aagaacctga ccccacacgg cgacaggtgt ttctcttcgg gggcagaggt    23280

ggaggcgatt gcgaagggct gcggtccgac ctggaaggcg gatgactggc agaacccctt    23340

ccgcgttcgg gggtgtgctc cctgtggcgg tcgcttaact gatttccttc gcggctggcc    23400

attgtgttct cctaggcaga gaaacaacag acatggaaac tcagccattg ctgtcaacat    23460

cgccacgagt gccatcacat ctcgtcctca gcgacgagga aaaggagcag agcttaagca    23520

ttccaccgcc cagtcctgcc accacctcta ccctagaaga taaggaggtc gacgcatctc    23580

atgacatgca gaataaaaaa gcgaaagagt ctgagacaga catcgagcaa gacccgggct    23640

atgtgacacc ggtggaacac gaggaagagt tgaaacgctt tctagagaga gaggatgaaa    23700

actgcccaaa acaacgagca gataactatc accaagatgc tggaaatagg gatcagaaca    23760

ccgactacct catagggctt gacggggaag acgcgctcct taaacatcta gcaagacagt    23820

cgctcatagt caaggatgca ttattggaca gaactgaagt gcccatcagt gtggaagagc    23880

tcagccgcgc ctacgagctt aacctctttt cacctcgtac tccccccaaa cgtcagccaa    23940

acggcacctg cgagccaaat cctcgcttaa acttttatcc agcttttgct gtgccagaag    24000

tactggctac ctatcacatc ttttttaaaa atcaaaaaat tccagtctcc tgccgcgcta    24060

atcgcacccg cgccgatgcc ctactcaatc tgggacctgg ttcacgctta cctgatatag    24120

cttccttgga agaggttcca aagatcttcg agggtctggg caataatgag actcgggccg    24180

caaatgctct gcaaaaggga gaaaatggca tggatgagca tcacagcgtt ctggtggaat    24240

tggaaggcga taatgccaga ctcgcagtac tcaagcgaag catcgaggtc acacacttcg    24300

catatcccgc tgtcaacctg ccccctaaag tcatgacggc ggtcatggac cagttactca    24360

ttaagcgcgc aagtcccctt tcagaagaca tgcatgaccc agatgcctgt gatgagggta    24420

aaccagtggt cagtgatgag cagctaaccc gatggctggg caccgactct cccagggatt    24480

tggaagagcg tcgcaagctt atgatggccg tggtgctggt taccgtagaa ctagagtgtc    24540

tccgacgttt ctttaccgat tcagaaacct tgcgcaaact cgaagagaat ctgcactaca    24600

cttttagaca cggctttgtg cggcaggcat gcaagatatc taacgtggaa ctcaccaacc    24660

tggtttccta catgggtatt ctgcatgaga atcgcctagg acaaagcgtg ctgcacagca    24720

ccctgaaggg ggaagcccgc cgtgattaca tccgcgattg tgtctatctg tacctgtgcc    24780

acacgtggca aaccggcatg ggtgtatggc agcaatgttt agaagaacag aacttgaaag    24840

agcttgacaa gctcttacag aaatctctta aggttctgtg gacagggttc gacgagcgca    24900

ccgtcgcttc cgacctggca gacctcatct tcccagagcg tctcagggtt actttgcgaa    24960

acggattgcc tgactttatg agccagagca tgcttaacaa ttttcgctct ttcatcctgg    25020

aacgctccgg tatcctgccc gccacctgct gcgcactgcc ctccgacttt gtgcctctca    25080

cctaccgcga gtgccccccg ccgctatgga gtcactgcta cctgttccgt ctggccaact    25140

atctctccta ccactcggat gtgatcgagg atgtgagcgg agacggcttg ctggagtgtc    25200

actgccgctg caatctgtgc acgccccacc ggtccctagc ttgcaacccc cagttgatga    25260

gcgaaaccca gataataggc acctttgaat tgcaaggccc cagcagccaa ggcgatgggt    25320

cttctcctgg gcaaagttta aaactgaccc cgggactgtg gacctccgcc tacttgcgca    25380

agtttgctcc ggaagattac cacccctatg aaatcaagtt ctatgaggac caatcacagc    25440

ctccaaaggc cgaactttcg gcctgcgtca tcacccaggg ggcaattctg gcccaattgc    25500

aagccatcca aaaatcccgc caagaatttc tactgaaaaa gggtaagggg gtctaccttg    25560

acccccagac cggcgaggaa ctcaacacaa ggttccctca ggatgtccca acgacgagaa    25620

aacaagaagt tgaaggtgca gccgccgccc ccagaagata tggaggaaga ttgggacagt    25680

caggcagagg aggcggagga ggacagtctg gaggacagtc tggaggaaga cagtttggag    25740

gaggaaaacg aggaggcaga ggaggtggaa gaagtaaccg ccgacaaaca gttatcctcg    25800

gctgcggaga caagcaacag cgctaccatc tccgctccga gtcgaggaac ccggcggcgt    25860

cccagcagta gatgggacga gaccggacgc ttcccgaacc caaccagcgc ttccaagacc    25920

ggtaagaagg atcggcaggg atacaagtcc tggcgggggc ataagaatgc catcatctcc    25980

tgcttgcatg agtgcggggg caacatatcc ttcacgcggc gctacttgct attccaccat    26040

ggggtgaact ttccgcgcaa tgttttgcat tactaccgtc acctccacag cccctactat    26100

agccagcaaa tcccggcagt ctcgacagat aaagacagcg gcggcgacct ccaacagaaa    26160

accagcagcg gcagttagaa aatacacaac aagtgcagca acaggaggat taaagattac    26220

agccaacgag ccagcgcaaa cccgagagtt aagaaatcgg atctttccaa ccctgtatgc    26280

catcttccag cagagtcggg gtcaagagca ggaactgaaa ataaaaaacc gatctctgcg    26340

ttcgctcacc agaagttgtt tgtatcacaa gagcgaagat caacttcagc gcactctcga    26400

ggacgccgag gctctcttca acaagtactg cgcgctgact cttaaagagt aggcagcgac    26460

cgcgcttatt caaaaaaggc gggaattaca tcatcctcga catgagtaaa gaaattccca    26520

cgccttacat gtggagttat caaccccaaa tgggattggc ggcaggcgcc tcccaggact    26580

actccacccg catgaattgg ctcagcgccg ggccttctat gatttctcga gttaatgata    26640

tacgcgccta ccgaaaccaa atacttttgg aacagtcagc tcttaccacc acgccccgcc    26700

aacaccttaa tcccagaaat tggcccgccg ccctagtgta ccaggaaagt cccgctccca    26760

ccactgtatt acttcctcga gacgcccagg ccgaagtcca aatgactaat gcaggtgcgc    26820

agttagctgg cggctccacc ctatgtcgtc acaggcctcg gcataatata aaacgcctga    26880

tgatcagagg ccgaggtatc cagctcaacg acgagtcggt gagctctccg cttggtctac    26940

gaccagacgg aatctttcag attgccggct gcgggagatc ttccttcacc cctcgtcagg    27000

ctgttctgac tttggaaagt tcgtcttcgc aaccccgctc gggcggaatc gggaccgttc    27060

aatttgtgga ggagtttact ccctctgtct acttcaaccc cttctccgga tctcctgggc    27120

attacccgga cgagttcata ccgaacttcg acgcgattag cgagtcagtg gacggctacg    27180

attgatgtct ggtgacgcgg ctgagctatc tcggctgcga catctagacc actgccgccg    27240

ctttcgctgc tttgcccggg aactcattga gttcatctac ttcgaactcc ccaaggatca    27300

ccctcaaggt ccggcccacg gagtgcggat ttctatcgaa ggcaaaatag actctcgcct    27360

gcaacgaatt ttctcccagc ggcccgtgct gatcgagcga gaccagggaa acaccacggt    27420

ttccatctac tgcatttgta atcaccccgg attgcatgaa agcctttgct gtcttatgtg    27480

tactgagttt aataaaaact gaattaagac tctcctacgg actgccgctt cttcaacccg    27540

gattttacaa ccagaagaac gaaacttttc ctgtcgtcca ggactctgtt aacttcacct    27600

ttcctactca caaactagaa gctcaacgac tacaccgctt ttccagaagc attttcccta    27660

ctaatactac tttcaaaacc ggaggtgagc tccaaggtct tcctacagaa aacccttggg    27720

tggaagcggg ccttgtagtg ctaggaattc ttgcgggtgg gcttgtgatt attctttgct    27780

acctatacac accttgcttc actttcttag tggtgttgtg gtattggttt aaaaaatggg    27840

gcccatacta gtcttgcttg ttttactttc gcttttggaa ccgggttctg ccaattacga    27900

tccatgtcta gacttcgacc cagaaaactg cacacttact tttgcacccg acacaagccg    27960

catctgtgga gttcatcgcc tctcttacga acttggcccc caacgacaaa aatttacctg    28020

catggtggga atcaacccca tagttatcac ccagcaaagt ggagatacta agggttgcat    28080

tcactgctcc tgcgattcca tcgagtgcac ctacaccctg ctgaagaccc tatgcggcct    28140

aagagacctg ctaccaatga attaaaaaat gattaataaa aaatcactta cttgaaatca    28200

gcaataaggt ctctgttgaa attttctccc agcagcacct cacttccctc ttcccaactc    28260

tggtattcta aaccccgttc agcggcatac tttctccata ctttaaaggg gatgtcaaat    28320

tttagctcct ctcctgtacc cacaatcttc atgtctttct tcccagatga ccaagagagt    28380

ccggctcagt gactccttca accctgtcta cccctatgaa gatgaaagca cctcccaaca    28440

cccctttata aacccagggt ttatttcccc aaatggcttc acacaaagcc caaacggagt    28500

tcttacttta aaatgtttaa ccccactaac aaccacaggc ggatctctac agctaaaagt    28560

gggaggggga cttacagtgg atgacaccaa cggttttttg aaagaaaaca taagtgccac    28620

cacaccactc gttaagactg gtcactctat aggtttacca ctaggagccg gattgggaac    28680

gaatgaaaat aaactttgta tcaaattagg acaaggactt acattcaatt caaacaacat    28740

ttgcattgat gacaatatta acaccttatg gacaggagtc aaccccaccg aagccaactg    28800

tcaaatcatg aactccagtg aatctaatga ttgcaaatta attctaacac tagttaaaac    28860

tggagcacta gtcactgcat ttgtttatgt tataggagta tctaacaatt ttaatatgct    28920

aactacacac agaaatataa attttactgc agagctgttt ttcgattcta ctggtaattt    28980

actaactaga ctctcatccc tcaaaactcc acttaatcat aaatcaggac aaaacatggc    29040

tactggtgcc attactaatg ctaaaggttt catgcccagc acgactgcct atcctttcaa    29100

tgataattct agagaaaaag aaaactacat ttacggaact tgttactaca cagctagtga    29160

tcgcactgct tttcccattg acatatctgt catgcttaac cgaagagcaa taaatgacga    29220

gacatcatat tgtattcgta taacttggtc ctggaacaca ggagatgccc cagaggtgca    29280

aacctctgct acaaccctag tcacctcccc atttaccttt tactacatca gagaagacga    29340

ctgacaaata aagtttgcga tcgccaggcc caccatggga tggagctgta tcatcctctt    29400

cttggtagca acagctacag gtgtccactc ccaggtgcag ctgcagcagt ctggggctga    29460

actggcaaga cctggggcct cagtgaagat gtcctgcaag gcttctggct acacctttac    29520

taggtacacg atgcactggg taaaacagag gcctggacag ggtctggaat ggattggata    29580

cattaatcct agccgtggtt atactaatta caatcagaag ttcaaggaca aggccacatt    29640

gactacagac aaatcctcca gcacagccta catgcaactg agcagcctga catctgagga    29700

ctctgcagtc tattactgtg caagatatta tgatgatcat tactgccttg actactgggg    29760

ccaaggcacc actctcacag tctcctcagg tggcggtggc tcgggcggtg gtggatctgg    29820

tggcggcgga tctgatatcg tgctcactca gtctccagca atcatgtctg catctccagg    29880

ggagaaggtc accatgacct gcagtgccag ctcaagtgta agttacatga actggtacca    29940

gcagaagtca ggcacctccc ccaaaagatg gatttatgac acatccaaac tggcttctgg    30000

agtccctgct cacttcaggg gcagtgggtc tgggacctct tactctctca caatcagcgg    30060

catggaggct gaagatgctg ccacttatta ctgccagcag tggagtagta acccattcac    30120

gttcggctcg gggacaaagt tggaaataaa ccggggatcc gaacaaaaac tcatctcaga    30180

agaggatctg aatgctgtgg gccaggacac gcaggaggtc atcgtggtgc cacactcctt    30240

gccctttaag gtggtggtga tctcagccat cctggccctg gtggtgctca ccatcatctc    30300

ccttatcatc ctcatcatgc tttggcagaa gaagccacgt ggaagcggag ctactaactt    30360

cagcctgctg aagcaggctg gagacgtgga ggagaaccct ggacctggcc acacacggag    30420

gcagggaaca tcaccatcca agtgtccata cctcaatttc tttcagctct tggtgctggc    30480

tggtctttct cacttctgtt caggtgttat ccacgtgacc aaggaagtga aagaagtggc    30540

aacgctgtcc tgtggtcaca atgtttctgt tgaagagctg gcacaaactc gcatctactg    30600

gcaaaaggag aagaaaatgg tgctgactat gatgtctggg gacatgaata tatggcccga    30660

gtacaagaac cggaccatct ttgatatcac taataacctc tccattgtga tcctggctct    30720

gcgcccatct gacgagggca catacgagtg tgttgttctg aagtatgaaa aagacgcttt    30780

caagcgggaa cacctggctg aagtgacgtt atcagtcaaa gctgacttcc ctacacctag    30840

tatatctgac tttgaaattc caacttctaa tattagaagg ataatttgct caacctctgg    30900

aggttttcca gagcctcacc tctcctggtt ggaaaatgga gaagaattaa atgccatcaa    30960

cacaacagtt tcccaagatc ctgaaactga gctctatgct gttagcagca aactggattt    31020

caatatgaca accaaccaca gcttcatgtg tctcatcaag tatggacatt taagagtgaa    31080

tcagaccttc aactggaata caaccaagca agagcatttt cctgataacc tgctcccatc    31140

ctgggccatt accttaatct cagtaaatgg aatttttgtg atatgctgcc tgacctactg    31200

ctttgcccca agatgcagag agagaaggag gaatgagaga ttgagaaggg aaagtgtacg    31260

ccctgtataa gctagcttga ctgactgaga tacagcgtac cttcagctca cagacatgat    31320

aagatacatt gatgagtttg gacaaaccac aactagaatg cagtgaaaaa aatgctttat    31380

ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ataagctgca ataaacaagt    31440

taacaacaac aattgcattc attttatgtt tcaggttcag ggggaggtgt gggaggtttt    31500

ttaaagcaag taaaacctct acaaatgtgg tagtcgtcag ctatcctgca ggaacttgtt    31560

tatttgaaaa tcaattcaca aaatccgagt agttattttg cctccccctt cccatttaac    31620

agaatacacc aatctctccc cacgcacagc tttaaacatt tggataccat tagatataga    31680

catggtttta gattccacat tccaaacagt ttcagagcga gccaatctgg ggtcagtgat    31740

agataaaaat ccatcgggat agtcttttaa agcgctttca cagtccaact gctgcggatg    31800

cgactccgga gtctggatca cggtcatctg gaagaagaac gatgggaatc ataatccgaa    31860

aacggtatcg gacgattgtg tctcatcaaa cccacaagca gccgctgtct gcgtcgctcc    31920

gtgcgactgc tgtttatggg atcagggtcc acagtgtcct gaagcatgat tttaatagcc    31980

cttaacatca actttctggt gcgatgcgcg cagcaacgca ttctgatttc actcaaatct    32040

ttgcagtagg tacaacacat tattacaata ttgtttaata aaccataatt aaaagcgctc    32100

cagccaaaac tcatatctga tataatcgcc cctgcatgac catcatacca aagtttaata    32160

taaattaaat gacgttccct caaaaacaca ctacccacat acatgatctc ttttggcatg    32220

tgcatattaa caatctgtct gtaccatgga caacgttggt taatcatgca acccaatata    32280

accttccgga accacactgc caacaccgct cccccagcca tgcattgaag tgaaccctgc    32340

tgattacaat gacaatgaag aacccaattc tctcgaccgt gaatcacttg agaatgaaaa    32400

atatctatag tggcacaaca tagacataaa tgcatgcatc ttctcataat ttttaactcc    32460

tcaggattta gaaacatatc ccagggaata ggaagctctt gcagaacagt aaagctggca    32520

gaacaaggaa gaccacgaac acaacttaca ctatgcatag tcatagtatc acaatctggc    32580

aacagcgggt ggtcttcagt catagaagct cgggtttcat tttcctcaca acgtggtaac    32640

tgggctctgg tgtaagggtg atgtctggcg catgatgtcg agcgtgcgcg caaccttgtc    32700

ataatggagt tgcttcctga cattctcgta ttttgtatag caaaacgcgg ccctggcaga    32760

acacactctt cttcgccttc tatcctgccg cttagcgtgt tccgtgtgat agttcaagta    32820

caaccacact cttaagttgg tcaaaagaat gctggcttca gttgtaatca aaactccatc    32880

gcatctaatc gttctgagga aatcatccaa gcaatgcaac tggattgtgt ttcaagcagg    32940

agaggagagg gaagagacgg aagaaccatg ttaattttta ttccaaacga tctcgcagta    33000

cttcaaattg tagatcgcgc agatggcatc tctcgccccc actgtgttgg tgaaaaagca    33060

cagctagatc aaaagaaatg cgattttcaa ggtgctcaac ggtggcttcc agcaaagcct    33120

ccacgcgcac atccaagaac aaaagaatac caaaagaagg agcattttct aactcctcaa    33180

tcatcatatt acattcctgc accattccca gataattttc agctttccag ccttgaatta    33240

ttcgtgtcag ttcttgtggt aaatccaatc cacacattac aaacaggtcc cggagggcgc    33300

cctccaccac cattcttaaa cacaccctca taatgacaaa atatcttgct cctgtgtcac    33360

ctgtagcgaa ttgagaatgg caacatcaat tgacatgccc ttggctctaa gttcttcttt    33420

aagttctagt tgtaaaaact ctctcatatt atcaccaaac tgcttagcca gaagcccccc    33480

gggaacaaga gcaggggacg ctacagtgca gtacaagcgc agacctcccc aattggctcc    33540

agcaaaaaca agattggaat aagcatattg ggaaccgcca gtaatatcat cgaagttgct    33600

ggaaatataa tcaggcagag tttcttgtaa aaattgaata aaagaaaaat ttgccaaaaa    33660

aacattcaaa acctctggga tgcaaatgca ataggttacc gcgctgcgct ccaacattgt    33720

tagttttgaa ttagtctgca aaaataaaaa aaaaaacaag cgtcatatca tagtagcctg    33780

acgaacagat ggataaatca gtctttccat cacaagacaa gccacagggt ctccagctcg    33840

accctcgtaa aacctgtcat catgattaaa caacagcacc gaaagttcct cgcggtgacc    33900

agcatgaata attcttgatg aagcatacaa tccagacatg ttagcatcag ttaacgagaa    33960

aaaacagcca acatagcctt tgggtataat tatgcttaat cgtaagtata gcaaagccac    34020

ccctcgcgga tacaaagtaa aaggcacagg agaataaaaa atataattat ttctctgctg    34080

ctgttcaggc aacgtcgccc ccggtccctc taaatacaca tacaaagcct catcagccat    34140

ggcttaccag acaaagtaca gcgggcacac aaagcacaag ctctaaagtg actctccaac    34200

ctctccacaa tatatatata cacaagccct aaactgacgt aatgggagta aagtgtaaaa    34260

aatcccgcca aacccaacac acaccccgaa actgcgtcac cagggaaaag tacagtttca    34320

cttccgcaat cccaacaggc gtaacttcct ctttctcacg gtacgtgata tcccactaac    34380

ttgcaacgtc attttcccac ggtcgcaccg ccccttttag ccgttaaccc cacagccaat    34440

caccacacga tccacacttt ttaaaatcac ctcatttaca tattggcacc attccatcta    34500

taaggtatat tatatagata ga                                             34522


<210>  13
<211>  2196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Transgene cassette sequence for NG-348

<400>  13
gcgatcgcca ggcccaccat gggatggagc tgtatcatcc tcttcttggt agcaacagct       60

acaggtgtcc actcccaggt gcagctgcag cagtctgggg ctgaactggc aagacctggg      120

gcctcagtga agatgtcctg caaggcttct ggctacacct ttactaggta cacgatgcac      180

tgggtaaaac agaggcctgg acagggtctg gaatggattg gatacattaa tcctagccgt      240

ggttatacta attacaatca gaagttcaag gacaaggcca cattgactac agacaaatcc      300

tccagcacag cctacatgca actgagcagc ctgacatctg aggactctgc agtctattac      360

tgtgcaagat attatgatga tcattactgc cttgactact ggggccaagg caccactctc      420

acagtctcct caggtggcgg tggctcgggc ggtggtggat ctggtggcgg cggatctgat      480

atcgtgctca ctcagtctcc agcaatcatg tctgcatctc caggggagaa ggtcaccatg      540

acctgcagtg ccagctcaag tgtaagttac atgaactggt accagcagaa gtcaggcacc      600

tcccccaaaa gatggattta tgacacatcc aaactggctt ctggagtccc tgctcacttc      660

aggggcagtg ggtctgggac ctcttactct ctcacaatca gcggcatgga ggctgaagat      720

gctgccactt attactgcca gcagtggagt agtaacccat tcacgttcgg ctcggggaca      780

aagttggaaa taaaccgggg atccgaacaa aaactcatct cagaagagga tctgaatgct      840

gtgggccagg acacgcagga ggtcatcgtg gtgccacact ccttgccctt taaggtggtg      900

gtgatctcag ccatcctggc cctggtggtg ctcaccatca tctcccttat catcctcatc      960

atgctttggc agaagaagcc acgtggaagc ggagctacta acttcagcct gctgaagcag     1020

gctggagacg tggaggagaa ccctggacct ggccacacac ggaggcaggg aacatcacca     1080

tccaagtgtc catacctcaa tttctttcag ctcttggtgc tggctggtct ttctcacttc     1140

tgttcaggtg ttatccacgt gaccaaggaa gtgaaagaag tggcaacgct gtcctgtggt     1200

cacaatgttt ctgttgaaga gctggcacaa actcgcatct actggcaaaa ggagaagaaa     1260

atggtgctga ctatgatgtc tggggacatg aatatatggc ccgagtacaa gaaccggacc     1320

atctttgata tcactaataa cctctccatt gtgatcctgg ctctgcgccc atctgacgag     1380

ggcacatacg agtgtgttgt tctgaagtat gaaaaagacg ctttcaagcg ggaacacctg     1440

gctgaagtga cgttatcagt caaagctgac ttccctacac ctagtatatc tgactttgaa     1500

attccaactt ctaatattag aaggataatt tgctcaacct ctggaggttt tccagagcct     1560

cacctctcct ggttggaaaa tggagaagaa ttaaatgcca tcaacacaac agtttcccaa     1620

gatcctgaaa ctgagctcta tgctgttagc agcaaactgg atttcaatat gacaaccaac     1680

cacagcttca tgtgtctcat caagtatgga catttaagag tgaatcagac cttcaactgg     1740

aatacaacca agcaagagca ttttcctgat aacctgctcc catcctgggc cattacctta     1800

atctcagtaa atggaatttt tgtgatatgc tgcctgacct actgctttgc cccaagatgc     1860

agagagagaa ggaggaatga gagattgaga agggaaagtg tacgccctgt ataagctagc     1920

ttgactgact gagatacagc gtaccttcag ctcacagaca tgataagata cattgatgag     1980

tttggacaaa ccacaactag aatgcagtga aaaaaatgct ttatttgtga aatttgtgat     2040

gctattgctt tatttgtaac cattataagc tgcaataaac aagttaacaa caacaattgc     2100

attcatttta tgtttcaggt tcagggggag gtgtgggagg ttttttaaag caagtaaaac     2160

ctctacaaat gtggtagtcg tcagctatcc tgcagg                               2196


<210>  14
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Membrane anchored form of the anti-human CD3 scFv with C-terminal
       V5 tag

<400>  14

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser 
145                 150                 155                 160 


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
                165                 170                 175     


Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser 
            180                 185                 190         


Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser 
        195                 200                 205             


Gly Val Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
    210                 215                 220                 


Leu Thr Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
225                 230                 235                 240 


Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu 
                245                 250                 255     


Glu Ile Asn Arg Gly Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            260                 265                 270         


Asn Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser 
        275                 280                 285             


Leu Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val 
    290                 295                 300                 


Leu Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys 
305                 310                 315                 320 


Pro Arg Gly Ser Ile Pro Asn Pro Leu Leu Gly Leu Asp 
                325                 330             


<210>  15
<211>  966
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Membrane tethered OKT3-ScFv nucleic acid sequence

<400>  15
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtgt ccactcccag       60

gtgcagctgc agcagtctgg ggctgaactg gcaagacctg gggcctcagt gaagatgtcc      120

tgcaaggctt ctggctacac ctttactagg tacacgatgc actgggtaaa acagaggcct      180

ggacagggtc tggaatggat tggatacatt aatcctagcc gtggttatac taattacaat      240

cagaagttca aggacaaggc cacattgact acagacaaat cctccagcac agcctacatg      300

caactgagca gcctgacatc tgaggactct gcagtctatt actgtgcaag atattatgat      360

gatcattact gccttgacta ctggggccaa ggcaccactc tcacagtctc ctcaggtggc      420

ggtggctcgg gcggtggtgg atctggtggc ggcggatctg atatcgtgct cactcagtct      480

ccagcaatca tgtctgcatc tccaggggag aaggtcacca tgacctgcag tgccagctca      540

agtgtaagtt acatgaactg gtaccagcag aagtcaggca cctcccccaa aagatggatt      600

tatgacacat ccaaactggc ttctggagtc cctgctcact tcaggggcag tgggtctggg      660

acctcttact ctctcacaat cagcggcatg gaggctgaag atgctgccac ttattactgc      720

cagcagtgga gtagtaaccc attcacgttc ggctcgggga caaagttgga aataaaccgg      780

ggatccgaac aaaaactcat ctcagaagag gatctgaatg ctgtgggcca ggacacgcag      840

gaggtcatcg tggtgccaca ctccttgccc tttaaggtgg tggtgatctc agccatcctg      900

gccctggtgg tgctcaccat catctccctt atcatcctca tcatgctttg gcagaagaag      960

ccacgt                                                                 966


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V5 tag (9 amino acid variant)

<400>  16

Ile Pro Asn Pro Leu Leu Gly Leu Asp 
1               5                   


<210>  17
<211>  32326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  EnAd Genome

<400>  17
tctatctata taatatacct tatagatgga atggtgccaa tatgtaaatg aggtgatttt       60

aaaaagtgtg gatcgtgtgg tgattggctg tggggttaac ggctaaaagg ggcggtgcga      120

ccgtgggaaa atgacgtttt gtgggggtgg agtttttttg caagttgtcg cgggaaatgt      180

gacgcataaa aaggcttttt tctcacggaa ctacttagtt ttcccacggt atttaacagg      240

aaatgaggta gttttgaccg gatgcaagtg aaaattgttg attttcgcgc gaaaactgaa      300

tgaggaagtg tttttctgaa taatgtggta tttatggcag ggtggagtat ttgttcaggg      360

ccaggtagac tttgacccat tacgtggagg tttcgattac cgtgtttttt acctgaattt      420

ccgcgtaccg tgtcaaagtc ttctgttttt acgtaggtgt cagctgatcg ctagggtatt      480

tatacctcag ggtttgtgtc aagaggccac tcttgagtgc cagcgagaag agttttctcc      540

tctgcgccgg cagtttaata ataaaaaaat gagagatttg cgatttctgc ctcaggaaat      600

aatctctgct gagactggaa atgaaatatt ggagcttgtg gtgcacgccc tgatgggaga      660

cgatccggag ccacctgtgc agctttttga gcctcctacg cttcaggaac tgtatgattt      720

agaggtagag ggatcggagg attctaatga ggaagctgta aatggctttt ttaccgattc      780

tatgctttta gctgctaatg aagggttaga attagatccg cctttggaca cttttgatac      840

tccaggggta attgtggaaa gcggtacagg tgtaagaaaa ttacctgatt tgagttccgt      900

ggactgtgat ttgcactgct atgaagacgg gtttcctccg agtgatgagg aggaccatga      960

aaaggagcag tccatgcaga ctgcagcggg tgagggagtg aaggctgcca atgttggttt     1020

tcagttggat tgcccggagc ttcctggaca tggctgtaag tcttgtgaat ttcacaggaa     1080

aaatactgga gtaaaggaac tgttatgttc gctttgttat atgagaacgc actgccactt     1140

tatttacagt aagtgtgttt aagttaaaat ttaaaggaat atgctgtttt tcacatgtat     1200

attgagtgtg agttttgtgc ttcttattat aggtcctgtg tctgatgctg atgaatcacc     1260

atctcctgat tctactacct cacctcctga gattcaagca cctgttcctg tggacgtgcg     1320

caagcccatt cctgtgaagc ttaagcctgg gaaacgtcca gcagtggaaa aacttgagga     1380

cttgttacag ggtggggacg gacctttgga cttgagtaca cggaaacgtc caagacaata     1440

agtgttccat atccgtgttt acttaaggtg acgtcaatat ttgtgtgaca gtgcaatgta     1500

ataaaaatat gttaactgtt cactggtttt tattgctttt tgggcgggga ctcaggtata     1560

taagtagaag cagacctgtg tggttagctc ataggagctg gctttcatcc atggaggttt     1620

gggccatttt ggaagacctt aggaagacta ggcaactgtt agagaacgct tcggacggag     1680

tctccggttt ttggagattc tggttcgcta gtgaattagc tagggtagtt tttaggataa     1740

aacaggacta taaacaagaa tttgaaaagt tgttggtaga ttgcccagga ctttttgaag     1800

ctcttaattt gggccatcag gttcacttta aagaaaaagt tttatcagtt ttagactttt     1860

caaccccagg tagaactgct gctgctgtgg cttttcttac ttttatatta gataaatgga     1920

tcccgcagac tcatttcagc aggggatacg ttttggattt catagccaca gcattgtgga     1980

gaacatggaa ggttcgcaag atgaggacaa tcttaggtta ctggccagtg cagcctttgg     2040

gtgtagcggg aatcctgagg catccaccgg tcatgccagc ggttctggag gaggaacagc     2100

aagaggacaa cccgagagcc ggcctggacc ctccagtgga ggaggcggag tagctgactt     2160

gtctcctgaa ctgcaacggg tgcttactgg atctacgtcc actggacggg ataggggcgt     2220

taagagggag agggcatcta gtggtactga tgctagatct gagttggctt taagtttaat     2280

gagtcgcaga cgtcctgaaa ccatttggtg gcatgaggtt cagaaagagg gaagggatga     2340

agtttctgta ttgcaggaga aatattcact ggaacaggtg aaaacatgtt ggttggagcc     2400

tgaggatgat tgggaggtgg ccattaaaaa ttatgccaag atagctttga ggcctgataa     2460

acagtataag attactagac ggattaatat ccggaatgct tgttacatat ctggaaatgg     2520

ggctgaggtg gtaatagata ctcaagacaa ggcagttatt agatgctgca tgatggatat     2580

gtggcctggg gtagtcggta tggaagcagt aacttttgta aatgttaagt ttaggggaga     2640

tggttataat ggaatagtgt ttatggccaa taccaaactt atattgcatg gttgtagctt     2700

ttttggtttc aacaatacct gtgtagatgc ctggggacag gttagtgtac ggggatgtag     2760

tttctatgcg tgttggattg ccacagctgg cagaaccaag agtcaattgt ctctgaagaa     2820

atgcatattt caaagatgta acctgggcat tctgaatgaa ggcgaagcaa gggtccgcca     2880

ctgcgcttct acagatactg gatgttttat tttgattaag ggaaatgcca gcgtaaagca     2940

taacatgatt tgcggtgctt ccgatgagag gccttatcaa atgctcactt gtgctggtgg     3000

gcattgtaat atgctggcta ctgtgcatat tgtttcccat caacgcaaaa aatggcctgt     3060

ttttgatcac aatgtgatga cgaagtgtac catgcatgca ggtgggcgta gaggaatgtt     3120

tatgccttac cagtgtaaca tgaatcatgt gaaagtgttg ttggaaccag atgccttttc     3180

cagaatgagc ctaacaggaa tttttgacat gaacatgcaa atctggaaga tcctgaggta     3240

tgatgatacg agatcgaggg tacgcgcatg cgaatgcgga ggcaagcatg ccaggttcca     3300

gccggtgtgt gtagatgtga ctgaagatct cagaccggat catttggtta ttgcccgcac     3360

tggagcagag ttcggatcca gtggagaaga aactgactaa ggtgagtatt gggaaaactt     3420

tggggtggga ttttcagatg gacagattga gtaaaaattt gttttttctg tcttgcagct     3480

gtcatgagtg gaaacgcttc ttttaagggg ggagtcttca gcccttatct gacagggcgt     3540

ctcccatcct gggcaggagt tcgtcagaat gttatgggat ctactgtgga tggaagaccc     3600

gtccaacccg ccaattcttc aacgctgacc tatgctactt taagttcttc acctttggac     3660

gcagctgcag ctgccgccgc cgcttctgtt gccgctaaca ctgtgcttgg aatgggttac     3720

tatggaagca tcatggctaa ttccacttcc tctaataacc cttctaccct gactcaggac     3780

aagttacttg tccttttggc ccagctggag gctttgaccc aacgtctggg tgaactttct     3840

cagcaggtgg tcgagttgcg agtacaaact gagtctgctg tcggcacggc aaagtctaaa     3900

taaaaaaatc ccagaatcaa tgaataaata aacaagcttg ttgttgattt aaaatcaagt     3960

gtttttattt catttttcgc gcacggtatg ccctagacca ccgatctcta tcattgagaa     4020

ctcggtggat tttttccagg atcctataga ggtgggattg aatgtttaga tacatgggca     4080

ttaggccgtc tttggggtgg agatagctcc attgaaggga ttcatgctcc ggggtagtgt     4140

tgtaaatcac ccagtcataa caaggtcgca gtgcatggtg ttgcacaata tcttttagaa     4200

gtaggctgat tgccacagat aagcccttgg tgtaggtgtt tacaaaccgg ttgagctggg     4260

atgggtgcat tcggggtgaa attatgtgca ttttggattg gatttttaag ttggcaatat     4320

tgccgccaag atcccgtctt gggttcatgt tatgaaggac caccaagacg gtgtatccgg     4380

tacatttagg aaatttatcg tgcagcttgg atggaaaagc gtggaaaaat ttggagacac     4440

ccttgtgtcc tccaagattt tccatgcact catccatgat aatagcaatg gggccgtggg     4500

cagcggcgcg ggcaaacacg ttccgtgggt ctgacacatc atagttatgt tcctgagtta     4560

aatcatcata agccatttta atgaatttgg ggcggagagt accagattgg ggtatgaatg     4620

ttccttcggg ccccggagca tagttcccct cacagatttg catttcccaa gctttcagtt     4680

ccgagggtgg aatcatgtcc acctgggggg ctatgaaaaa caccgtttct ggggcggggg     4740

tgattaattg tgatgatagc aaatttctga gcaattgaga tttgccacat ccggtggggc     4800

cataaatgat tccgattacg ggttgcaggt ggtagtttag ggaacggcaa ctgccgtctt     4860

ctcgaagcaa gggggccacc tcgttcatca tttcccttac atgcatattt tcccgcacca     4920

aatccattag gaggcgctct cctcctagtg atagaagttc ttgtagtgag gaaaagtttt     4980

tcagcggttt cagaccgtca gccatgggca ttttggagag agtttgctgc aaaagttcta     5040

gtctgttcca cagttcagtg atgtgttcta tggcatctcg atccagcaga cctcctcgtt     5100

tcgcgggttt ggacggctcc tggaataggg tatgagacga tgggcgtcca gcgctgccag     5160

ggttcggtcc ttccagggtc tcagtgttcg agtcagggtt gtttccgtca cagtgaaggg     5220

gtgtgcgcct gcttgggcgc ttgccagggt gcgcttcaga ctcatcctgc tggtcgaaaa     5280

cttctgtcgc ttggcgccct gtatgtcggc caagtagcag tttaccatga gttcgtagtt     5340

gagcgcctcg gctgcgtggc ctttggcgcg gagcttacct ttggaagttt tcttgcatac     5400

cgggcagtat aggcatttca gcgcatacaa cttgggcgca aggaaaacgg attctgggga     5460

gtatgcatct gcgccgcagg aggcgcaaac agtttcacat tccaccagcc aggttaaatc     5520

cggttcattg gggtcaaaaa caagttttcc gccatatttt ttgatgcgtt tcttaccttt     5580

ggtctccatg agttcgtgtc ctcgttgagt gacaaacagg ctgtccgtgt ccccgtagac     5640

tgattttaca ggcctcttct ccagtggagt gcctcggtct tcttcgtaca ggaactctga     5700

ccactctgat acaaaggcgc gcgtccaggc cagcacaaag gaggctatgt gggaggggta     5760

gcgatcgttg tcaaccaggg ggtccacctt ttccaaagta tgcaaacaca tgtcaccctc     5820

ttcaacatcc aggaatgtga ttggcttgta ggtgtatttc acgtgacctg gggtccccgc     5880

tgggggggta taaaaggggg cggttctttg ctcttcctca ctgtcttccg gatcgctgtc     5940

caggaacgtc agctgttggg gtaggtattc cctctcgaag gcgggcatga cctctgcact     6000

caggttgtca gtttctaaga acgaggagga tttgatattg acagtgccgg ttgagatgcc     6060

tttcatgagg ttttcgtcca tctggtcaga aaacacaatt tttttattgt caagtttggt     6120

ggcaaatgat ccatacaggg cgttggataa aagtttggca atggatcgca tggtttggtt     6180

cttttccttg tccgcgcgct ctttggcggc gatgttgagt tggacatact cgcgtgccag     6240

gcacttccat tcggggaaga tagttgttaa ttcatctggc acgattctca cttgccaccc     6300

tcgattatgc aaggtaatta aatccacact ggtggccacc tcgcctcgaa ggggttcatt     6360

ggtccaacag agcctacctc ctttcctaga acagaaaggg ggaagtgggt ctagcataag     6420

ttcatcggga gggtctgcat ccatggtaaa gattcccgga agtaaatcct tatcaaaata     6480

gctgatggga gtggggtcat ctaaggccat ttgccattct cgagctgcca gtgcgcgctc     6540

atatgggtta aggggactgc cccatggcat gggatgggtg agtgcagagg catacatgcc     6600

acagatgtca tagacgtaga tgggatcctc aaagatgcct atgtaggttg gatagcatcg     6660

cccccctctg atacttgctc gcacatagtc atatagttca tgtgatggcg ctagcagccc     6720

cggacccaag ttggtgcgat tgggtttttc tgttctgtag acgatctggc gaaagatggc     6780

gtgagaattg gaagagatgg tgggtctttg aaaaatgttg aaatgggcat gaggtagacc     6840

tacagagtct ctgacaaagt gggcataaga ttcttgaagc ttggttacca gttcggcggt     6900

gacaagtacg tctagggcgc agtagtcaag tgtttcttga atgatgtcat aacctggttg     6960

gtttttcttt tcccacagtt cgcggttgag aaggtattct tcgcgatcct tccagtactc     7020

ttctagcgga aacccgtctt tgtctgcacg gtaagatcct agcatgtaga actgattaac     7080

tgccttgtaa gggcagcagc ccttctctac gggtagagag tatgcttgag cagcttttcg     7140

tagcgaagcg tgagtaaggg caaaggtgtc tctgaccatg actttgagga attggtattt     7200

gaagtcgatg tcgtcacagg ctccctgttc ccagagttgg aagtctaccc gtttcttgta     7260

ggcggggttg ggcaaagcga aagtaacatc attgaagaga atcttgccgg ccctgggcat     7320

gaaattgcga gtgatgcgaa aaggctgtgg tacttccgct cggttattga taacctgggc     7380

agctaggacg atctcgtcga aaccgttgat gttgtgtcct acgatgtata attctatgaa     7440

acgcggcgtg cctctgacgt gaggtagctt actgagctca tcaaaggtta ggtctgtggg     7500

gtcagataag gcgtagtgtt cgagagccca ttcgtgcagg tgaggattcg ctttaaggaa     7560

ggaggaccag aggtccactg ccagtgctgt ttgtaactgg tcccggtact gacgaaaatg     7620

ccgtccgact gccatttttt ctggggtgac gcaatagaag gtttgggggt cctgccgcca     7680

gcgatcccac ttgagtttta tggcgaggtc ataggcgatg ttgacgagcc gctggtctcc     7740

agagagtttc atgaccagca tgaaggggat tagctgcttg ccaaaggacc ccatccaggt     7800

gtaggtttcc acatcgtagg tgagaaagag cctttctgtg cgaggatgag agccaatcgg     7860

gaagaactgg atctcctgcc accagttgga ggaatggctg ttgatgtgat ggaagtagaa     7920

ctccctgcga cgcgccgagc attcatgctt gtgcttgtac agacggccgc agtagtcgca     7980

gcgttgcacg ggttgtatct cgtgaatgag ttgtacctgg cttcccttga cgagaaattt     8040

cagtgggaag ccgaggcctg gcgattgtat ctcgtgcttt actatgttgt ctgcatcggc     8100

ctgttcatct tctgtctcga tggtggtcat gctgacgagc cctcgcggga ggcaagtcca     8160

gacctcggcg cggcaggggc ggagctcgag gacgagagcg cgcaggctgg agctgtccag     8220

ggtcctgaga cgctgcggac tcaggttagt aggcagtgtc aggagattaa cttgcatgat     8280

cttttggagg gcgtgcggga ggttcagata gtacttgatc tcaacgggtc cgttggtgga     8340

gatgtcgatg gcttgcaggg ttccgtgtcc cttgggcgct accaccgtgc ccttgttttt     8400

cattttggac ggcggtggct ctgttgcttc ttgcatgttt agaagcggtg tcgagggcgc     8460

gcaccgggcg gcaggggcgg ctcgggaccc ggcggcatgg ctggcagtgg tacgtcggcg     8520

ccgcgcgcgg gtaggttctg gtactgcgcc ctgagaagac tcgcatgcgc gacgacgcgg     8580

cggttgacat cctggatctg acgcctctgg gtgaaagcta ccggccccgt gagcttgaac     8640

ctgaaagaga gttcaacaga atcaatctcg gtatcgttga cggcggcttg cctaaggatt     8700

tcttgcacgt caccagagtt gtcctggtag gcgatctccg ccatgaactg ctcgatctct     8760

tcctcttgaa gatctccgcg gcccgctctc tcgacggtgg ccgcgaggtc gttggagatg     8820

cgcccaatga gttgagagaa tgcattcatg cccgcctcgt tccagacgcg gctgtagacc     8880

acggccccca cgggatctct cgcgcgcatg accacctggg cgaggttgag ctccacgtgg     8940

cgggtgaaga ccgcatagtt gcataggcgc tggaaaaggt agttgagtgt ggtggcgatg     9000

tgctcggtga cgaagaaata catgatccat cgtctcagcg gcatctcgct gacatcgccc     9060

agagcttcca agcgctccat ggcctcgtag aagtccacgg caaaattaaa aaactgggag     9120

tttcgcgcgg acacggtcaa ctcctcttcc agaagacgga taagttcggc gatggtggtg     9180

cgcacctcgc gctcgaaagc ccctgggatt tcttcctcaa tctcttcttc ttccactaac     9240

atctcttcct cttcaggtgg ggctgcagga ggagggggaa cgcggcgacg ccggcggcgc     9300

acgggcagac ggtcgatgaa tctttcaatg acctctccgc ggcggcggcg catggtttca     9360

gtgacggcgc ggccgttctc gcgcggtcgc agagtaaaaa caccgccgcg catctcctta     9420

aagtggtgac tgggaggttc tccgtttggg agggagaggg cgctgattat acattttatt     9480

aattggcccg tagggactgc acgcagagat ctgatcgtgt caagatccac gggatctgaa     9540

aacctttcga cgaaagcgtc taaccagtca cagtcacaag gtaggctgag tacggcttct     9600

tgtgggcggg ggtggttatg tgttcggtct gggtcttctg tttcttcttc atctcgggaa     9660

ggtgagacga tgctgctggt gatgaaatta aagtaggcag ttctaagacg gcggatggtg     9720

gcgaggagca ccaggtcttt gggtccggct tgctggatac gcaggcgatt ggccattccc     9780

caagcattat cctgacatct agcaagatct ttgtagtagt cttgcatgag ccgttctacg     9840

ggcacttctt cctcacccgt tctgccatgc atacgtgtga gtccaaatcc gcgcattggt     9900

tgtaccagtg ccaagtcagc tacgactctt tcggcgagga tggcttgctg tacttgggta     9960

agggtggctt gaaagtcatc aaaatccaca aagcggtggt aagctcctgt attaatggtg    10020

taagcacagt tggccatgac tgaccagtta actgtctggt gaccagggcg cacgagctcg    10080

gtgtatttaa ggcgcgaata ggcgcgggtg tcaaagatgt aatcgttgca ggtgcgcacc    10140

agatactggt accctataag aaaatgcggc ggtggttggc ggtagagagg ccatcgttct    10200

gtagctggag cgccaggggc gaggtcttcc aacataaggc ggtgatagcc gtagatgtac    10260

ctggacatcc aggtgattcc tgcggcggta gtagaagccc gaggaaactc gcgtacgcgg    10320

ttccaaatgt tgcgtagcgg catgaagtag ttcattgtag gcacggtttg accagtgagg    10380

cgcgcgcagt cattgatgct ctatagacac ggagaaaatg aaagcgttca gcgactcgac    10440

tccgtagcct ggaggaacgt gaacgggttg ggtcgcggtg taccccggtt cgagacttgt    10500

actcgagccg gccggagccg cggctaacgt ggtattggca ctcccgtctc gacccagcct    10560

acaaaaatcc aggatacgga atcgagtcgt tttgctggtt tccgaatggc agggaagtga    10620

gtcctatttt ttttttttgc cgctcagatg catcccgtgc tgcgacagat gcgcccccaa    10680

caacagcccc cctcgcagca gcagcagcag caatcacaaa aggctgtccc tgcaactact    10740

gcaactgccg ccgtgagcgg tgcgggacag cccgcctatg atctggactt ggaagagggc    10800

gaaggactgg cacgtctagg tgcgccttca cccgagcggc atccgcgagt tcaactgaaa    10860

aaagattctc gcgaggcgta tgtgccccaa cagaacctat ttagagacag aagcggcgag    10920

gagccggagg agatgcgagc ttcccgcttt aacgcgggtc gtgagctgcg tcacggtttg    10980

gaccgaagac gagtgttgcg ggacgaggat ttcgaagttg atgaaatgac agggatcagt    11040

cctgccaggg cacacgtggc tgcagccaac cttgtatcgg cttacgagca gacagtaaag    11100

gaagagcgta acttccaaaa gtcttttaat aatcatgtgc gaaccctgat tgcccgcgaa    11160

gaagttaccc ttggtttgat gcatttgtgg gatttgatgg aagctatcat tcagaaccct    11220

actagcaaac ctctgaccgc ccagctgttt ctggtggtgc aacacagcag agacaatgag    11280

gctttcagag aggcgctgct gaacatcacc gaacccgagg ggagatggtt gtatgatctt    11340

atcaacattc tacagagtat catagtgcag gagcggagcc tgggcctggc cgagaaggtg    11400

gctgccatca attactcggt tttgagcttg ggaaaatatt acgctcgcaa aatctacaag    11460

actccatacg ttcccataga caaggaggtg aagatagatg ggttctacat gcgcatgacg    11520

ctcaaggtct tgaccctgag cgatgatctt ggggtgtatc gcaatgacag aatgcatcgc    11580

gcggttagcg ccagcaggag gcgcgagtta agcgacaggg aactgatgca cagtttgcaa    11640

agagctctga ctggagctgg aaccgagggt gagaattact tcgacatggg agctgacttg    11700

cagtggcagc ctagtcgcag ggctctgagc gccgcgacgg caggatgtga gcttccttac    11760

atagaagagg cggatgaagg cgaggaggaa gagggcgagt acttggaaga ctgatggcac    11820

aacccgtgtt ttttgctaga tggaacagca agcaccggat cccgcaatgc gggcggcgct    11880

gcagagccag ccgtccggca ttaactcctc ggacgattgg acccaggcca tgcaacgtat    11940

catggcgttg acgactcgca accccgaagc ctttagacag caaccccagg ccaaccgtct    12000

atcggccatc atggaagctg tagtgccttc ccgctctaat cccactcatg agaaggtcct    12060

ggccatcgtg aacgcgttgg tggagaacaa agctattcgt ccagatgagg ccggactggt    12120

atacaacgct ctcttagaac gcgtggctcg ctacaacagt agcaatgtgc aaaccaattt    12180

ggaccgtatg ataacagatg tacgcgaagc cgtgtctcag cgcgaaaggt tccagcgtga    12240

tgccaacctg ggttcgctgg tggcgttaaa tgctttcttg agtactcagc ctgctaatgt    12300

gccgcgtggt caacaggatt atactaactt tttaagtgct ttgagactga tggtatcaga    12360

agtacctcag agcgaagtgt atcagtccgg tcctgattac ttctttcaga ctagcagaca    12420

gggcttgcag acggtaaatc tgagccaagc ttttaaaaac cttaaaggtt tgtggggagt    12480

gcatgccccg gtaggagaaa gagcaaccgt gtctagcttg ttaactccga actcccgcct    12540

attattactg ttggtagctc ctttcaccga cagcggtagc atcgaccgta attcctattt    12600

gggttaccta ctaaacctgt atcgcgaagc catagggcaa agtcaggtgg acgagcagac    12660

ctatcaagaa attacccaag tcagtcgcgc tttgggacag gaagacactg gcagtttgga    12720

agccactctg aacttcttgc ttaccaatcg gtctcaaaag atccctcctc aatatgctct    12780

tactgcggag gaggagagga tccttagata tgtgcagcag agcgtgggat tgtttctgat    12840

gcaagagggg gcaactccga ctgcagcact ggacatgaca gcgcgaaata tggagcccag    12900

catgtatgcc agtaaccgac ctttcattaa caaactgctg gactacttgc acagagctgc    12960

cgctatgaac tctgattatt tcaccaatgc catcttaaac ccgcactggc tgcccccacc    13020

tggtttctac acgggcgaat atgacatgcc cgaccctaat gacggatttc tgtgggacga    13080

cgtggacagc gatgtttttt cacctctttc tgatcatcgc acgtggaaaa aggaaggcgg    13140

cgatagaatg cattcttctg catcgctgtc cggggtcatg ggtgctaccg cggctgagcc    13200

cgagtctgca agtccttttc ctagtctacc cttttctcta cacagtgtac gtagcagcga    13260

agtgggtaga ataagtcgcc cgagtttaat gggcgaagag gagtatctaa acgattcctt    13320

gctcagaccg gcaagagaaa aaaatttccc aaacaatgga atagaaagtt tggtggataa    13380

aatgagtaga tggaagactt atgctcagga tcacagagac gagcctggga tcatggggat    13440

tacaagtaga gcgagccgta gacgccagcg ccatgacaga cagaggggtc ttgtgtggga    13500

cgatgaggat tcggccgatg atagcagcgt gctggacttg ggtgggagag gaaggggcaa    13560

cccgtttgct catttgcgcc ctcgcttggg tggtatgttg taaaaaaaaa taaaaaaaaa    13620

actcaccaag gccatggcga cgagcgtacg ttcgttcttc tttattatct gtgtctagta    13680

taatgaggcg agtcgtgcta ggcggagcgg tggtgtatcc ggagggtcct cctccttcgt    13740

acgagagcgt gatgcagcag cagcaggcga cggcggtgat gcaatcccca ctggaggctc    13800

cctttgtgcc tccgcgatac ctggcaccta cggagggcag aaacagcatt cgttattcgg    13860

aactggcacc tcagtacgat accaccaggt tgtatctggt ggacaacaag tcggcggaca    13920

ttgcttctct gaactatcag aatgaccaca gcaacttctt gaccacggtg gtgcaaaaca    13980

atgactttac ccctacggaa gccagcaccc agaccattaa ctttgatgaa cgatcgcggt    14040

ggggcggtca gctaaagacc atcatgcata ctaacatgcc aaacgtgaac gagtatatgt    14100

ttagtaacaa gttcaaagcg cgtgtgatgg tgtccagaaa acctcccgac ggtgctgcag    14160

ttggggatac ttatgatcac aagcaggata ttttgaaata tgagtggttc gagtttactt    14220

tgccagaagg caacttttca gttactatga ctattgattt gatgaacaat gccatcatag    14280

ataattactt gaaagtgggt agacagaatg gagtgcttga aagtgacatt ggtgttaagt    14340

tcgacaccag gaacttcaag ctgggatggg atcccgaaac caagttgatc atgcctggag    14400

tgtatacgta tgaagccttc catcctgaca ttgtcttact gcctggctgc ggagtggatt    14460

ttaccgagag tcgtttgagc aaccttcttg gtatcagaaa aaaacagcca tttcaagagg    14520

gttttaagat tttgtatgaa gatttagaag gtggtaatat tccggccctc ttggatgtag    14580

atgcctatga gaacagtaag aaagaacaaa aagccaaaat agaagctgct acagctgctg    14640

cagaagctaa ggcaaacata gttgccagcg actctacaag ggttgctaac gctggagagg    14700

tcagaggaga caattttgcg ccaacacctg ttccgactgc agaatcatta ttggccgatg    14760

tgtctgaagg aacggacgtg aaactcacta ttcaacctgt agaaaaagat agtaagaata    14820

gaagctataa tgtgttggaa gacaaaatca acacagccta tcgcagttgg tatctttcgt    14880

acaattatgg cgatcccgaa aaaggagtgc gttcctggac attgctcacc acctcagatg    14940

tcacctgcgg agcagagcag gtctactggt cgcttccaga catgatgaag gatcctgtca    15000

ctttccgctc cactagacaa gtcagtaact accctgtggt gggtgcagag cttatgcccg    15060

tcttctcaaa gagcttctac aacgaacaag ctgtgtactc ccagcagctc cgccagtcca    15120

cctcgcttac gcacgtcttc aaccgctttc ctgagaacca gattttaatc cgtccgccgg    15180

cgcccaccat taccaccgtc agtgaaaacg ttcctgctct cacagatcac gggaccctgc    15240

cgttgcgcag cagtatccgg ggagtccaac gtgtgaccgt tactgacgcc agacgccgca    15300

cctgtcccta cgtgtacaag gcactgggca tagtcgcacc gcgcgtcctt tcaagccgca    15360

ctttctaaaa aaaaaaaaaa tgtccattct tatctcgccc agtaataaca ccggttgggg    15420

tctgcgcgct ccaagcaaga tgtacggagg cgcacgcaaa cgttctaccc aacatcctgt    15480

ccgtgttcgc ggacattttc gcgctccatg gggcgccctc aagggccgca ctcgcgttcg    15540

aaccaccgtc gatgatgtaa tcgatcaggt ggttgccgac gcccgtaatt atactcctac    15600

tgcgcctaca tctactgtgg atgcagttat tgacagtgta gtggctgacg ctcgcaacta    15660

tgctcgacgt aagagccggc gaaggcgcat tgccagacgc caccgagcta ccactgccat    15720

gcgagccgca agagctctgc tacgaagagc tagacgcgtg gggcgaagag ccatgcttag    15780

ggcggccaga cgtgcagctt cgggcgccag cgccggcagg tcccgcaggc aagcagccgc    15840

tgtcgcagcg gcgactattg ccgacatggc ccaatcgcga agaggcaatg tatactgggt    15900

gcgtgacgct gccaccggtc aacgtgtacc cgtgcgcacc cgtccccctc gcacttagaa    15960

gatactgagc agtctccgat gttgtgtccc agcggcgagg atgtccaagc gcaaatacaa    16020

ggaagaaatg ctgcaggtta tcgcacctga agtctacggc caaccgttga aggatgaaaa    16080

aaaaccccgc aaaatcaagc gggttaaaaa ggacaaaaaa gaagaggaag atggcgatga    16140

tgggctggcg gagtttgtgc gcgagtttgc cccacggcga cgcgtgcaat ggcgtgggcg    16200

caaagttcga catgtgttga gacctggaac ttcggtggtc tttacacccg gcgagcgttc    16260

aagcgctact tttaagcgtt cctatgatga ggtgtacggg gatgatgata ttcttgagca    16320

ggcggctgac cgattaggcg agtttgctta tggcaagcgt agtagaataa cttccaagga    16380

tgagacagtg tcgataccct tggatcatgg aaatcccacc cctagtctta aaccggtcac    16440

tttgcagcaa gtgttacccg taactccgcg aacaggtgtt aaacgcgaag gtgaagattt    16500

gtatcccact atgcaactga tggtacccaa acgccagaag ttggaggacg ttttggagaa    16560

agtaaaagtg gatccagata ttcaacctga ggttaaagtg agacccatta agcaggtagc    16620

gcctggtctg ggggtacaaa ctgtagacat taagattccc actgaaagta tggaagtgca    16680

aactgaaccc gcaaagccta ctgccacctc cactgaagtg caaacggatc catggatgcc    16740

catgcctatt acaactgacg ccgccggtcc cactcgaaga tcccgacgaa agtacggtcc    16800

agcaagtctg ttgatgccca attatgttgt acacccatct attattccta ctcctggtta    16860

ccgaggcact cgctactatc gcagccgaaa cagtacctcc cgccgtcgcc gcaagacacc    16920

tgcaaatcgc agtcgtcgcc gtagacgcac aagcaaaccg actcccggcg ccctggtgcg    16980

gcaagtgtac cgcaatggta gtgcggaacc tttgacactg ccgcgtgcgc gttaccatcc    17040

gagtatcatc acttaatcaa tgttgccgct gcctccttgc agatatggcc ctcacttgtc    17100

gccttcgcgt tcccatcact ggttaccgag gaagaaactc gcgccgtaga agagggatgt    17160

tgggacgcgg aatgcgacgc tacaggcgac ggcgtgctat ccgcaagcaa ttgcggggtg    17220

gttttttacc agccttaatt ccaattatcg ctgctgcaat tggcgcgata ccaggcatag    17280

cttccgtggc ggttcaggcc tcgcaacgac attgacattg gaaaaaaacg tataaataaa    17340

aaaaaaaaaa tacaatggac tctgacactc ctggtcctgt gactatgttt tcttagagat    17400

ggaagacatc aatttttcat ccttggctcc gcgacacggc acgaagccgt acatgggcac    17460

ctggagcgac atcggcacga gccaactgaa cgggggcgcc ttcaattgga gcagtatctg    17520

gagcgggctt aaaaattttg gctcaaccat aaaaacatac gggaacaaag cttggaacag    17580

cagtacagga caggcgctta gaaataaact taaagaccag aacttccaac aaaaagtagt    17640

cgatgggata gcttccggca tcaatggagt ggtagatttg gctaaccagg ctgtgcagaa    17700

aaagataaac agtcgtttgg acccgccgcc agcaacccca ggtgaaatgc aagtggagga    17760

agaaattcct ccgccagaaa aacgaggcga caagcgtccg cgtcccgatt tggaagagac    17820

gctggtgacg cgcgtagatg aaccgccttc ttatgaggaa gcaacgaagc ttggaatgcc    17880

caccactaga ccgatagccc caatggccac cggggtgatg aaaccttctc agttgcatcg    17940

acccgtcacc ttggatttgc cccctccccc tgctgctact gctgtacccg cttctaagcc    18000

tgtcgctgcc ccgaaaccag tcgccgtagc caggtcacgt cccgggggcg ctcctcgtcc    18060

aaatgcgcac tggcaaaata ctctgaacag catcgtgggt ctaggcgtgc aaagtgtaaa    18120

acgccgtcgc tgcttttaat taaatatgga gtagcgctta acttgcctat ctgtgtatat    18180

gtgtcattac acgccgtcac agcagcagag gaaaaaagga agaggtcgtg cgtcgacgct    18240

gagttacttt caagatggcc accccatcga tgctgcccca atgggcatac atgcacatcg    18300

ccggacagga tgcttcggag tacctgagtc cgggtctggt gcagttcgcc cgcgccacag    18360

acacctactt caatctggga aataagttta gaaatcccac cgtagcgccg acccacgatg    18420

tgaccaccga ccgtagccag cggctcatgt tgcgcttcgt gcccgttgac cgggaggaca    18480

atacatactc ttacaaagtg cggtacaccc tggccgtggg cgacaacaga gtgctggata    18540

tggccagcac gttctttgac attaggggtg tgttggacag aggtcccagt ttcaaaccct    18600

attctggtac ggcttacaac tccctggctc ctaaaggcgc tccaaataca tctcagtgga    18660

ttgcagaagg tgtaaaaaat acaactggtg aggaacacgt aacagaagag gaaaccaata    18720

ctactactta cacttttggc aatgctcctg taaaagctga agctgaaatt acaaaagaag    18780

gactcccagt aggtttggaa gtttcagatg aagaaagtaa accgatttat gctgataaaa    18840

catatcagcc agaacctcag ctgggagatg aaacttggac tgaccttgat ggaaaaaccg    18900

aaaagtatgg aggcagggct ctcaaacccg atactaagat gaaaccatgc tacgggtcct    18960

ttgccaaacc tactaatgtg aaaggcggtc aggcaaaaca aaaaacaacg gagcagccaa    19020

atcagaaagt cgaatatgat atcgacatgg agttttttga tgcggcatcg cagaaaacaa    19080

acttaagtcc taaaattgtc atgtatgcag aaaatgtaaa tttggaaact ccagacactc    19140

atgtagtgta caaacctgga acagaagaca caagttccga agctaatttg ggacaacaat    19200

ctatgcccaa cagacccaac tacattggct tcagagataa ctttattgga cttatgtact    19260

ataacagtac tggtaacatg ggggtgctgg ctggtcaagc gtctcagtta aatgcagtgg    19320

ttgacttgca ggacagaaac acagaacttt cttaccaact cttgcttgac tctctgggcg    19380

acagaaccag atactttagc atgtggaatc aggctgtgga cagttatgat cctgatgtac    19440

gtgttattga aaatcatggt gtggaagatg aacttcccaa ctactgtttt ccactggacg    19500

gcataggtgt tccaacaacc agttacaaat caatagttcc aaatggagac aatgcgccta    19560

attggaagga acctgaagta aatggaacaa gtgagatcgg acagggtaat ttgtttgcca    19620

tggaaattaa ccttcaagcc aatctatggc gaagtttcct ttattccaat gtggctctat    19680

atctcccaga ctcgtacaaa tacaccccgt ccaatgtcac tcttccagaa aacaaaaaca    19740

cctacgacta catgaacggg cgggtggtgc cgccatctct agtagacacc tatgtgaaca    19800

ttggtgccag gtggtctctg gatgccatgg acaatgtcaa cccattcaac caccaccgta    19860

acgctggctt gcgttaccga tccatgcttc tgggtaacgg acgttatgtg cctttccaca    19920

tacaagtgcc tcaaaaattc ttcgctgtta aaaacctgct gcttctccca ggctcctaca    19980

cttatgagtg gaactttagg aaggatgtga acatggttct acagagttcc ctcggtaacg    20040

acctgcgggt agatggcgcc agcatcagtt tcacgagcat caacctctat gctacttttt    20100

tccccatggc tcacaacacc gcttccaccc ttgaagccat gctgcggaat gacaccaatg    20160

atcagtcatt caacgactac ctatctgcag ctaacatgct ctaccccatt cctgccaatg    20220

caaccaatat tcccatttcc attccttctc gcaactgggc ggctttcaga ggctggtcat    20280

ttaccagact gaaaaccaaa gaaactccct ctttggggtc tggatttgac ccctactttg    20340

tctattctgg ttctattccc tacctggatg gtaccttcta cctgaaccac acttttaaga    20400

aggtttccat catgtttgac tcttcagtga gctggcctgg aaatgacagg ttactatctc    20460

ctaacgaatt tgaaataaag cgcactgtgg atggcgaagg ctacaacgta gcccaatgca    20520

acatgaccaa agactggttc ttggtacaga tgctcgccaa ctacaacatc ggctatcagg    20580

gcttctacat tccagaagga tacaaagatc gcatgtattc atttttcaga aacttccagc    20640

ccatgagcag gcaggtggtt gatgaggtca attacaaaga cttcaaggcc gtcgccatac    20700

cctaccaaca caacaactct ggctttgtgg gttacatggc tccgaccatg cgccaaggtc    20760

aaccctatcc cgctaactat ccctatccac tcattggaac aactgccgta aatagtgtta    20820

cgcagaaaaa gttcttgtgt gacagaacca tgtggcgcat accgttctcg agcaacttca    20880

tgtctatggg ggcccttaca gacttgggac agaatatgct ctatgccaac tcagctcatg    20940

ctctggacat gacctttgag gtggatccca tggatgagcc caccctgctt tatcttctct    21000

tcgaagtttt cgacgtggtc agagtgcatc agccacaccg cggcatcatc gaggcagtct    21060

acctgcgtac accgttctcg gccggtaacg ctaccacgta agaagcttct tgcttcttgc    21120

aaatagcagc tgcaaccatg gcctgcggat cccaaaacgg ctccagcgag caagagctca    21180

gagccattgt ccaagacctg ggttgcggac cctatttttt gggaacctac gataagcgct    21240

tcccggggtt catggccccc gataagctcg cctgtgccat tgtaaatacg gccggacgtg    21300

agacgggggg agagcactgg ttggctttcg gttggaaccc acgttctaac acctgctacc    21360

tttttgatcc ttttggattc tcggatgatc gtctcaaaca gatttaccag tttgaatatg    21420

agggtctcct gcgccgcagc gctcttgcta ccaaggaccg ctgtattacg ctggaaaaat    21480

ctacccagac cgtgcagggt ccccgttctg ccgcctgcgg acttttctgc tgcatgttcc    21540

ttcacgcctt tgtgcactgg cctgaccgtc ccatggacgg aaaccccacc atgaaattgc    21600

taactggagt gccaaacaac atgcttcatt ctcctaaagt ccagcccacc ctgtgtgaca    21660

atcaaaaagc actctaccat tttcttaata cccattcgcc ttattttcgc tcccatcgta    21720

cacacatcga aagggccact gcgttcgacc gtatggatgt tcaataatga ctcatgtaaa    21780

caacgtgttc aataaacatc actttatttt tttacatgta tcaaggctct gcattactta    21840

tttatttaca agtcgaatgg gttctgacga gaatcagaat gacccgcagg cagtgatacg    21900

ttgcggaact gatacttggg ttgccacttg aattcgggaa tcaccaactt gggaaccggt    21960

atatcgggca ggatgtcact ccacagcttt ctggtcagct gcaaagctcc aagcaggtca    22020

ggagccgaaa tcttgaaatc acaattagga ccagtgcttt gagcgcgaga gttgcggtac    22080

accggattgc agcactgaaa caccatcagc gacggatgtc tcacgcttgc cagcacggtg    22140

ggatctgcaa tcatgcccac atccagatct tcagcattgg caatgctgaa cggggtcatc    22200

ttgcaggtct gcctacccat ggcgggcacc caattaggct tgtggttgca atcgcagtgc    22260

agggggatca gtatcatctt ggcctgatcc tgtctgattc ctggatacac ggctctcatg    22320

aaagcatcat attgcttgaa agcctgctgg gctttactac cctcggtata aaacatcccg    22380

caggacctgc tcgaaaactg gttagctgca cagccggcat cattcacaca gcagcgggcg    22440

tcattgttag ctatttgcac cacacttctg ccccagcggt tttgggtgat tttggttcgc    22500

tcgggattct cctttaaggc tcgttgtccg ttctcgctgg ccacatccat ctcgataatc    22560

tgctccttct gaatcataat attgccatgc aggcacttca gcttgccctc ataatcattg    22620

cagccatgag gccacaacgc acagcctgta cattcccaat tatggtgggc gatctgagaa    22680

aaagaatgta tcattccctg cagaaatctt cccatcatcg tgctcagtgt cttgtgacta    22740

gtgaaagtta actggatgcc tcggtgctcc tcgtttacgt actggtgaca gatgcgcttg    22800

tattgttcgt gttgctcagg cattagttta aaagaggttc taagttcgtt atccagcctg    22860

tacttctcca tcagcagaca catcacttcc atgcctttct cccaagcaga caccaggggc    22920

aagctaatcg gattcttaac agtgcaggca gcagctcctt tagccagagg gtcatcttta    22980

gcgatcttct caatgcttct tttgccatcc ttctcaacga tgcgcacggg cgggtagctg    23040

aaacccactg ctacaagttg cgcctcttct ctttcttctt cgctgtcttg actgatgtct    23100

tgcatgggga tatgtttggt cttccttggc ttctttttgg ggggtatcgg aggaggagga    23160

ctgtcgctcc gttccggaga cagggaggat tgtgacgttt cgctcaccat taccaactga    23220

ctgtcggtag aagaacctga ccccacacgg cgacaggtgt ttctcttcgg gggcagaggt    23280

ggaggcgatt gcgaagggct gcggtccgac ctggaaggcg gatgactggc agaacccctt    23340

ccgcgttcgg gggtgtgctc cctgtggcgg tcgcttaact gatttccttc gcggctggcc    23400

attgtgttct cctaggcaga gaaacaacag acatggaaac tcagccattg ctgtcaacat    23460

cgccacgagt gccatcacat ctcgtcctca gcgacgagga aaaggagcag agcttaagca    23520

ttccaccgcc cagtcctgcc accacctcta ccctagaaga taaggaggtc gacgcatctc    23580

atgacatgca gaataaaaaa gcgaaagagt ctgagacaga catcgagcaa gacccgggct    23640

atgtgacacc ggtggaacac gaggaagagt tgaaacgctt tctagagaga gaggatgaaa    23700

actgcccaaa acaacgagca gataactatc accaagatgc tggaaatagg gatcagaaca    23760

ccgactacct catagggctt gacggggaag acgcgctcct taaacatcta gcaagacagt    23820

cgctcatagt caaggatgca ttattggaca gaactgaagt gcccatcagt gtggaagagc    23880

tcagccgcgc ctacgagctt aacctctttt cacctcgtac tccccccaaa cgtcagccaa    23940

acggcacctg cgagccaaat cctcgcttaa acttttatcc agcttttgct gtgccagaag    24000

tactggctac ctatcacatc ttttttaaaa atcaaaaaat tccagtctcc tgccgcgcta    24060

atcgcacccg cgccgatgcc ctactcaatc tgggacctgg ttcacgctta cctgatatag    24120

cttccttgga agaggttcca aagatcttcg agggtctggg caataatgag actcgggccg    24180

caaatgctct gcaaaaggga gaaaatggca tggatgagca tcacagcgtt ctggtggaat    24240

tggaaggcga taatgccaga ctcgcagtac tcaagcgaag catcgaggtc acacacttcg    24300

catatcccgc tgtcaacctg ccccctaaag tcatgacggc ggtcatggac cagttactca    24360

ttaagcgcgc aagtcccctt tcagaagaca tgcatgaccc agatgcctgt gatgagggta    24420

aaccagtggt cagtgatgag cagctaaccc gatggctggg caccgactct cccagggatt    24480

tggaagagcg tcgcaagctt atgatggccg tggtgctggt taccgtagaa ctagagtgtc    24540

tccgacgttt ctttaccgat tcagaaacct tgcgcaaact cgaagagaat ctgcactaca    24600

cttttagaca cggctttgtg cggcaggcat gcaagatatc taacgtggaa ctcaccaacc    24660

tggtttccta catgggtatt ctgcatgaga atcgcctagg acaaagcgtg ctgcacagca    24720

ccctgaaggg ggaagcccgc cgtgattaca tccgcgattg tgtctatctg tacctgtgcc    24780

acacgtggca aaccggcatg ggtgtatggc agcaatgttt agaagaacag aacttgaaag    24840

agcttgacaa gctcttacag aaatctctta aggttctgtg gacagggttc gacgagcgca    24900

ccgtcgcttc cgacctggca gacctcatct tcccagagcg tctcagggtt actttgcgaa    24960

acggattgcc tgactttatg agccagagca tgcttaacaa ttttcgctct ttcatcctgg    25020

aacgctccgg tatcctgccc gccacctgct gcgcactgcc ctccgacttt gtgcctctca    25080

cctaccgcga gtgccccccg ccgctatgga gtcactgcta cctgttccgt ctggccaact    25140

atctctccta ccactcggat gtgatcgagg atgtgagcgg agacggcttg ctggagtgtc    25200

actgccgctg caatctgtgc acgccccacc ggtccctagc ttgcaacccc cagttgatga    25260

gcgaaaccca gataataggc acctttgaat tgcaaggccc cagcagccaa ggcgatgggt    25320

cttctcctgg gcaaagttta aaactgaccc cgggactgtg gacctccgcc tacttgcgca    25380

agtttgctcc ggaagattac cacccctatg aaatcaagtt ctatgaggac caatcacagc    25440

ctccaaaggc cgaactttcg gcctgcgtca tcacccaggg ggcaattctg gcccaattgc    25500

aagccatcca aaaatcccgc caagaatttc tactgaaaaa gggtaagggg gtctaccttg    25560

acccccagac cggcgaggaa ctcaacacaa ggttccctca ggatgtccca acgacgagaa    25620

aacaagaagt tgaaggtgca gccgccgccc ccagaagata tggaggaaga ttgggacagt    25680

caggcagagg aggcggagga ggacagtctg gaggacagtc tggaggaaga cagtttggag    25740

gaggaaaacg aggaggcaga ggaggtggaa gaagtaaccg ccgacaaaca gttatcctcg    25800

gctgcggaga caagcaacag cgctaccatc tccgctccga gtcgaggaac ccggcggcgt    25860

cccagcagta gatgggacga gaccggacgc ttcccgaacc caaccagcgc ttccaagacc    25920

ggtaagaagg atcggcaggg atacaagtcc tggcgggggc ataagaatgc catcatctcc    25980

tgcttgcatg agtgcggggg caacatatcc ttcacgcggc gctacttgct attccaccat    26040

ggggtgaact ttccgcgcaa tgttttgcat tactaccgtc acctccacag cccctactat    26100

agccagcaaa tcccggcagt ctcgacagat aaagacagcg gcggcgacct ccaacagaaa    26160

accagcagcg gcagttagaa aatacacaac aagtgcagca acaggaggat taaagattac    26220

agccaacgag ccagcgcaaa cccgagagtt aagaaatcgg atctttccaa ccctgtatgc    26280

catcttccag cagagtcggg gtcaagagca ggaactgaaa ataaaaaacc gatctctgcg    26340

ttcgctcacc agaagttgtt tgtatcacaa gagcgaagat caacttcagc gcactctcga    26400

ggacgccgag gctctcttca acaagtactg cgcgctgact cttaaagagt aggcagcgac    26460

cgcgcttatt caaaaaaggc gggaattaca tcatcctcga catgagtaaa gaaattccca    26520

cgccttacat gtggagttat caaccccaaa tgggattggc ggcaggcgcc tcccaggact    26580

actccacccg catgaattgg ctcagcgccg ggccttctat gatttctcga gttaatgata    26640

tacgcgccta ccgaaaccaa atacttttgg aacagtcagc tcttaccacc acgccccgcc    26700

aacaccttaa tcccagaaat tggcccgccg ccctagtgta ccaggaaagt cccgctccca    26760

ccactgtatt acttcctcga gacgcccagg ccgaagtcca aatgactaat gcaggtgcgc    26820

agttagctgg cggctccacc ctatgtcgtc acaggcctcg gcataatata aaacgcctga    26880

tgatcagagg ccgaggtatc cagctcaacg acgagtcggt gagctctccg cttggtctac    26940

gaccagacgg aatctttcag attgccggct gcgggagatc ttccttcacc cctcgtcagg    27000

ctgttctgac tttggaaagt tcgtcttcgc aaccccgctc gggcggaatc gggaccgttc    27060

aatttgtgga ggagtttact ccctctgtct acttcaaccc cttctccgga tctcctgggc    27120

attacccgga cgagttcata ccgaacttcg acgcgattag cgagtcagtg gacggctacg    27180

attgatgtct ggtgacgcgg ctgagctatc tcggctgcga catctagacc actgccgccg    27240

ctttcgctgc tttgcccggg aactcattga gttcatctac ttcgaactcc ccaaggatca    27300

ccctcaaggt ccggcccacg gagtgcggat ttctatcgaa ggcaaaatag actctcgcct    27360

gcaacgaatt ttctcccagc ggcccgtgct gatcgagcga gaccagggaa acaccacggt    27420

ttccatctac tgcatttgta atcaccccgg attgcatgaa agcctttgct gtcttatgtg    27480

tactgagttt aataaaaact gaattaagac tctcctacgg actgccgctt cttcaacccg    27540

gattttacaa ccagaagaac gaaacttttc ctgtcgtcca ggactctgtt aacttcacct    27600

ttcctactca caaactagaa gctcaacgac tacaccgctt ttccagaagc attttcccta    27660

ctaatactac tttcaaaacc ggaggtgagc tccaaggtct tcctacagaa aacccttggg    27720

tggaagcggg ccttgtagtg ctaggaattc ttgcgggtgg gcttgtgatt attctttgct    27780

acctatacac accttgcttc actttcttag tggtgttgtg gtattggttt aaaaaatggg    27840

gcccatacta gtcttgcttg ttttactttc gcttttggaa ccgggttctg ccaattacga    27900

tccatgtcta gacttcgacc cagaaaactg cacacttact tttgcacccg acacaagccg    27960

catctgtgga gttcatcgcc tctcttacga acttggcccc caacgacaaa aatttacctg    28020

catggtggga atcaacccca tagttatcac ccagcaaagt ggagatacta agggttgcat    28080

tcactgctcc tgcgattcca tcgagtgcac ctacaccctg ctgaagaccc tatgcggcct    28140

aagagacctg ctaccaatga attaaaaaat gattaataaa aaatcactta cttgaaatca    28200

gcaataaggt ctctgttgaa attttctccc agcagcacct cacttccctc ttcccaactc    28260

tggtattcta aaccccgttc agcggcatac tttctccata ctttaaaggg gatgtcaaat    28320

tttagctcct ctcctgtacc cacaatcttc atgtctttct tcccagatga ccaagagagt    28380

ccggctcagt gactccttca accctgtcta cccctatgaa gatgaaagca cctcccaaca    28440

cccctttata aacccagggt ttatttcccc aaatggcttc acacaaagcc caaacggagt    28500

tcttacttta aaatgtttaa ccccactaac aaccacaggc ggatctctac agctaaaagt    28560

gggaggggga cttacagtgg atgacaccaa cggttttttg aaagaaaaca taagtgccac    28620

cacaccactc gttaagactg gtcactctat aggtttacca ctaggagccg gattgggaac    28680

gaatgaaaat aaactttgta tcaaattagg acaaggactt acattcaatt caaacaacat    28740

ttgcattgat gacaatatta acaccttatg gacaggagtc aaccccaccg aagccaactg    28800

tcaaatcatg aactccagtg aatctaatga ttgcaaatta attctaacac tagttaaaac    28860

tggagcacta gtcactgcat ttgtttatgt tataggagta tctaacaatt ttaatatgct    28920

aactacacac agaaatataa attttactgc agagctgttt ttcgattcta ctggtaattt    28980

actaactaga ctctcatccc tcaaaactcc acttaatcat aaatcaggac aaaacatggc    29040

tactggtgcc attactaatg ctaaaggttt catgcccagc acgactgcct atcctttcaa    29100

tgataattct agagaaaaag aaaactacat ttacggaact tgttactaca cagctagtga    29160

tcgcactgct tttcccattg acatatctgt catgcttaac cgaagagcaa taaatgacga    29220

gacatcatat tgtattcgta taacttggtc ctggaacaca ggagatgccc cagaggtgca    29280

aacctctgct acaaccctag tcacctcccc atttaccttt tactacatca gagaagacga    29340

ctgacaaata aagtttaact tgtttatttg aaaatcaatt cacaaaatcc gagtagttat    29400

tttgcctccc ccttcccatt taacagaata caccaatctc tccccacgca cagctttaaa    29460

catttggata ccattagata tagacatggt tttagattcc acattccaaa cagtttcaga    29520

gcgagccaat ctggggtcag tgatagataa aaatccatcg ggatagtctt ttaaagcgct    29580

ttcacagtcc aactgctgcg gatgcgactc cggagtctgg atcacggtca tctggaagaa    29640

gaacgatggg aatcataatc cgaaaacggt atcggacgat tgtgtctcat caaacccaca    29700

agcagccgct gtctgcgtcg ctccgtgcga ctgctgttta tgggatcagg gtccacagtg    29760

tcctgaagca tgattttaat agcccttaac atcaactttc tggtgcgatg cgcgcagcaa    29820

cgcattctga tttcactcaa atctttgcag taggtacaac acattattac aatattgttt    29880

aataaaccat aattaaaagc gctccagcca aaactcatat ctgatataat cgcccctgca    29940

tgaccatcat accaaagttt aatataaatt aaatgacgtt ccctcaaaaa cacactaccc    30000

acatacatga tctcttttgg catgtgcata ttaacaatct gtctgtacca tggacaacgt    30060

tggttaatca tgcaacccaa tataaccttc cggaaccaca ctgccaacac cgctccccca    30120

gccatgcatt gaagtgaacc ctgctgatta caatgacaat gaagaaccca attctctcga    30180

ccgtgaatca cttgagaatg aaaaatatct atagtggcac aacatagaca taaatgcatg    30240

catcttctca taatttttaa ctcctcagga tttagaaaca tatcccaggg aataggaagc    30300

tcttgcagaa cagtaaagct ggcagaacaa ggaagaccac gaacacaact tacactatgc    30360

atagtcatag tatcacaatc tggcaacagc gggtggtctt cagtcataga agctcgggtt    30420

tcattttcct cacaacgtgg taactgggct ctggtgtaag ggtgatgtct ggcgcatgat    30480

gtcgagcgtg cgcgcaacct tgtcataatg gagttgcttc ctgacattct cgtattttgt    30540

atagcaaaac gcggccctgg cagaacacac tcttcttcgc cttctatcct gccgcttagc    30600

gtgttccgtg tgatagttca agtacaacca cactcttaag ttggtcaaaa gaatgctggc    30660

ttcagttgta atcaaaactc catcgcatct aatcgttctg aggaaatcat ccaagcaatg    30720

caactggatt gtgtttcaag caggagagga gagggaagag acggaagaac catgttaatt    30780

tttattccaa acgatctcgc agtacttcaa attgtagatc gcgcagatgg catctctcgc    30840

ccccactgtg ttggtgaaaa agcacagcta gatcaaaaga aatgcgattt tcaaggtgct    30900

caacggtggc ttccagcaaa gcctccacgc gcacatccaa gaacaaaaga ataccaaaag    30960

aaggagcatt ttctaactcc tcaatcatca tattacattc ctgcaccatt cccagataat    31020

tttcagcttt ccagccttga attattcgtg tcagttcttg tggtaaatcc aatccacaca    31080

ttacaaacag gtcccggagg gcgccctcca ccaccattct taaacacacc ctcataatga    31140

caaaatatct tgctcctgtg tcacctgtag cgaattgaga atggcaacat caattgacat    31200

gcccttggct ctaagttctt ctttaagttc tagttgtaaa aactctctca tattatcacc    31260

aaactgctta gccagaagcc ccccgggaac aagagcaggg gacgctacag tgcagtacaa    31320

gcgcagacct ccccaattgg ctccagcaaa aacaagattg gaataagcat attgggaacc    31380

gccagtaata tcatcgaagt tgctggaaat ataatcaggc agagtttctt gtaaaaattg    31440

aataaaagaa aaatttgcca aaaaaacatt caaaacctct gggatgcaaa tgcaataggt    31500

taccgcgctg cgctccaaca ttgttagttt tgaattagtc tgcaaaaata aaaaaaaaaa    31560

caagcgtcat atcatagtag cctgacgaac agatggataa atcagtcttt ccatcacaag    31620

acaagccaca gggtctccag ctcgaccctc gtaaaacctg tcatcatgat taaacaacag    31680

caccgaaagt tcctcgcggt gaccagcatg aataattctt gatgaagcat acaatccaga    31740

catgttagca tcagttaacg agaaaaaaca gccaacatag cctttgggta taattatgct    31800

taatcgtaag tatagcaaag ccacccctcg cggatacaaa gtaaaaggca caggagaata    31860

aaaaatataa ttatttctct gctgctgttc aggcaacgtc gcccccggtc cctctaaata    31920

cacatacaaa gcctcatcag ccatggctta ccagacaaag tacagcgggc acacaaagca    31980

caagctctaa agtgactctc caacctctcc acaatatata tatacacaag ccctaaactg    32040

acgtaatggg agtaaagtgt aaaaaatccc gccaaaccca acacacaccc cgaaactgcg    32100

tcaccaggga aaagtacagt ttcacttccg caatcccaac aggcgtaact tcctctttct    32160

cacggtacgt gatatcccac taacttgcaa cgtcattttc ccacggtcgc accgcccctt    32220

ttagccgtta accccacagc caatcaccac acgatccaca ctttttaaaa tcacctcatt    32280

tacatattgg caccattcca tctataaggt atattatata gataga                   32326


<210>  18
<211>  5288
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E2B region of EnAd genome (bp 1066-5068)

<400>  18
ctatggcatc tcgatccagc agacctcctc gtttcgcggg tttggacggc tcctggaata       60

gggtatgaga cgatgggcgt ccagcgctgc cagggttcgg tccttccagg gtctcagtgt      120

tcgagtcagg gttgtttccg tcacagtgaa ggggtgtgcg cctgcttggg cgcttgccag      180

ggtgcgcttc agactcatcc tgctggtcga aaacttctgt cgcttggcgc cctgtatgtc      240

ggccaagtag cagtttacca tgagttcgta gttgagcgcc tcggctgcgt ggcctttggc      300

gcggagctta cctttggaag ttttcttgca taccgggcag tataggcatt tcagcgcata      360

caacttgggc gcaaggaaaa cggattctgg ggagtatgca tctgcgccgc aggaggcgca      420

aacagtttca cattccacca gccaggttaa atccggttca ttggggtcaa aaacaagttt      480

tccgccatat tttttgatgc gtttcttacc tttggtctcc atgagttcgt gtcctcgttg      540

agtgacaaac aggctgtccg tgtccccgta gactgatttt acaggcctct tctccagtgg      600

agtgcctcgg tcttcttcgt acaggaactc tgaccactct gatacaaagg cgcgcgtcca      660

ggccagcaca aaggaggcta tgtgggaggg gtagcgatcg ttgtcaacca gggggtccac      720

cttttccaaa gtatgcaaac acatgtcacc ctcttcaaca tccaggaatg tgattggctt      780

gtaggtgtat ttcacgtgac ctggggtccc cgctgggggg gtataaaagg gggcggttct      840

ttgctcttcc tcactgtctt ccggatcgct gtccaggaac gtcagctgtt ggggtaggta      900

ttccctctcg aaggcgggca tgacctctgc actcaggttg tcagtttcta agaacgagga      960

ggatttgata ttgacagtgc cggttgagat gcctttcatg aggttttcgt ccatctggtc     1020

agaaaacaca atttttttat tgtcaagttt ggtggcaaat gatccataca gggcgttgga     1080

taaaagtttg gcaatggatc gcatggtttg gttcttttcc ttgtccgcgc gctctttggc     1140

ggcgatgttg agttggacat actcgcgtgc caggcacttc cattcgggga agatagttgt     1200

taattcatct ggcacgattc tcacttgcca ccctcgatta tgcaaggtaa ttaaatccac     1260

actggtggcc acctcgcctc gaaggggttc attggtccaa cagagcctac ctcctttcct     1320

agaacagaaa gggggaagtg ggtctagcat aagttcatcg ggagggtctg catccatggt     1380

aaagattccc ggaagtaaat ccttatcaaa atagctgatg ggagtggggt catctaaggc     1440

catttgccat tctcgagctg ccagtgcgcg ctcatatggg ttaaggggac tgccccatgg     1500

catgggatgg gtgagtgcag aggcatacat gccacagatg tcatagacgt agatgggatc     1560

ctcaaagatg cctatgtagg ttggatagca tcgcccccct ctgatacttg ctcgcacata     1620

gtcatatagt tcatgtgatg gcgctagcag ccccggaccc aagttggtgc gattgggttt     1680

ttctgttctg tagacgatct ggcgaaagat ggcgtgagaa ttggaagaga tggtgggtct     1740

ttgaaaaatg ttgaaatggg catgaggtag acctacagag tctctgacaa agtgggcata     1800

agattcttga agcttggtta ccagttcggc ggtgacaagt acgtctaggg cgcagtagtc     1860

aagtgtttct tgaatgatgt cataacctgg ttggtttttc ttttcccaca gttcgcggtt     1920

gagaaggtat tcttcgcgat ccttccagta ctcttctagc ggaaacccgt ctttgtctgc     1980

acggtaagat cctagcatgt agaactgatt aactgccttg taagggcagc agcccttctc     2040

tacgggtaga gagtatgctt gagcagcttt tcgtagcgaa gcgtgagtaa gggcaaaggt     2100

gtctctgacc atgactttga ggaattggta tttgaagtcg atgtcgtcac aggctccctg     2160

ttcccagagt tggaagtcta cccgtttctt gtaggcgggg ttgggcaaag cgaaagtaac     2220

atcattgaag agaatcttgc cggccctggg catgaaattg cgagtgatgc gaaaaggctg     2280

tggtacttcc gctcggttat tgataacctg ggcagctagg acgatctcgt cgaaaccgtt     2340

gatgttgtgt cctacgatgt ataattctat gaaacgcggc gtgcctctga cgtgaggtag     2400

cttactgagc tcatcaaagg ttaggtctgt ggggtcagat aaggcgtagt gttcgagagc     2460

ccattcgtgc aggtgaggat tcgctttaag gaaggaggac cagaggtcca ctgccagtgc     2520

tgtttgtaac tggtcccggt actgacgaaa atgccgtccg actgccattt tttctggggt     2580

gacgcaatag aaggtttggg ggtcctgccg ccagcgatcc cacttgagtt ttatggcgag     2640

gtcataggcg atgttgacga gccgctggtc tccagagagt ttcatgacca gcatgaaggg     2700

gattagctgc ttgccaaagg accccatcca ggtgtaggtt tccacatcgt aggtgagaaa     2760

gagcctttct gtgcgaggat gagagccaat cgggaagaac tggatctcct gccaccagtt     2820

ggaggaatgg ctgttgatgt gatggaagta gaactccctg cgacgcgccg agcattcatg     2880

cttgtgcttg tacagacggc cgcagtagtc gcagcgttgc acgggttgta tctcgtgaat     2940

gagttgtacc tggcttccct tgacgagaaa tttcagtggg aagccgaggc ctggcgattg     3000

tatctcgtgc tttactatgt tgtctgcatc ggcctgttca tcttctgtct cgatggtggt     3060

catgctgacg agccctcgcg ggaggcaagt ccagacctcg gcgcggcagg ggcggagctc     3120

gaggacgaga gcgcgcaggc tggagctgtc cagggtcctg agacgctgcg gactcaggtt     3180

agtaggcagt gtcaggagat taacttgcat gatcttttgg agggcgtgcg ggaggttcag     3240

atagtacttg atctcaacgg gtccgttggt ggagatgtcg atggcttgca gggttccgtg     3300

tcccttgggc gctaccaccg tgcccttgtt tttcattttg gacggcggtg gctctgttgc     3360

ttcttgcatg tttagaagcg gtgtcgaggg cgcgcaccgg gcggcagggg cggctcggga     3420

cccggcggca tggctggcag tggtacgtcg gcgccgcgcg cgggtaggtt ctggtactgc     3480

gccctgagaa gactcgcatg cgcgacgacg cggcggttga catcctggat ctgacgcctc     3540

tgggtgaaag ctaccggccc cgtgagcttg aacctgaaag agagttcaac agaatcaatc     3600

tcggtatcgt tgacggcggc ttgcctaagg atttcttgca cgtcaccaga gttgtcctgg     3660

taggcgatct ccgccatgaa ctgctcgatc tcttcctctt gaagatctcc gcggcccgct     3720

ctctcgacgg tggccgcgag gtcgttggag atgcgcccaa tgagttgaga gaatgcattc     3780

atgcccgcct cgttccagac gcggctgtag accacggccc ccacgggatc tctcgcgcgc     3840

atgaccacct gggcgaggtt gagctccacg tggcgggtga agaccgcata gttgcatagg     3900

cgctggaaaa ggtagttgag tgtggtggcg atgtgctcgg tgacgaagaa atacatgatc     3960

catcgtctca gcggcatctc gctgacatcg cccagagctt ccaagcgctc catggcctcg     4020

tagaagtcca cggcaaaatt aaaaaactgg gagtttcgcg cggacacggt caactcctct     4080

tccagaagac ggataagttc ggcgatggtg gtgcgcacct cgcgctcgaa agcccctggg     4140

atttcttcct caatctcttc ttcttccact aacatctctt cctcttcagg tggggctgca     4200

ggaggagggg gaacgcggcg acgccggcgg cgcacgggca gacggtcgat gaatctttca     4260

atgacctctc cgcggcggcg gcgcatggtt tcagtgacgg cgcggccgtt ctcgcgcggt     4320

cgcagagtaa aaacaccgcc gcgcatctcc ttaaagtggt gactgggagg ttctccgttt     4380

gggagggaga gggcgctgat tatacatttt attaattggc ccgtagggac tgcacgcaga     4440

gatctgatcg tgtcaagatc cacgggatct gaaaaccttt cgacgaaagc gtctaaccag     4500

tcacagtcac aaggtaggct gagtacggct tcttgtgggc gggggtggtt atgtgttcgg     4560

tctgggtctt ctgtttcttc ttcatctcgg gaaggtgaga cgatgctgct ggtgatgaaa     4620

ttaaagtagg cagttctaag acggcggatg gtggcgagga gcaccaggtc tttgggtccg     4680

gcttgctgga tacgcaggcg attggccatt ccccaagcat tatcctgaca tctagcaaga     4740

tctttgtagt agtcttgcat gagccgttct acgggcactt cttcctcacc cgttctgcca     4800

tgcatacgtg tgagtccaaa tccgcgcatt ggttgtacca gtgccaagtc agctacgact     4860

ctttcggcga ggatggcttg ctgtacttgg gtaagggtgg cttgaaagtc atcaaaatcc     4920

acaaagcggt ggtaagctcc tgtattaatg gtgtaagcac agttggccat gactgaccag     4980

ttaactgtct ggtgaccagg gcgcacgagc tcggtgtatt taaggcgcga ataggcgcgg     5040

gtgtcaaaga tgtaatcgtt gcaggtgcgc accagatact ggtaccctat aagaaaatgc     5100

ggcggtggtt ggcggtagag aggccatcgt tctgtagctg gagcgccagg ggcgaggtct     5160

tccaacataa ggcggtgata gccgtagatg tacctggaca tccaggtgat tcctgcggcg     5220

gtagtagaag cccgaggaaa ctcgcgtacg cggttccaaa tgttgcgtag cggcatgaag     5280

tagttcat                                                              5288


<210>  19
<211>  981
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E3 region from EnAd

<400>  19
atgtctggtg acgcggctga gctatctcgg ctgcgacatc tagaccactg ccgccgcttt       60

cgctgctttg cccgggaact cattgagttc atctacttcg aactccccaa ggatcaccct      120

caaggtccgg cccacggagt gcggatttct atcgaaggca aaatagactc tcgcctgcaa      180

cgaattttct cccagcggcc cgtgctgatc gagcgagacc agggaaacac cacggtttcc      240

atctactgca tttgtaatca ccccggattg catgaaagcc tttgctgtct tatgtgtact      300

gagtttaata aaaactgaat taagactctc ctacggactg ccgcttcttc aacccggatt      360

ttacaaccag aagaacgaaa cttttcctgt cgtccaggac tctgttaact tcacctttcc      420

tactcacaaa ctagaagctc aacgactaca ccgcttttcc agaagcattt tccctactaa      480

tactactttc aaaaccggag gtgagctcca aggtcttcct acagaaaacc cttgggtgga      540

agcgggcctt gtagtgctag gaattcttgc gggtgggctt gtgattattc tttgctacct      600

atacacacct tgcttcactt tcttagtggt gttgtggtat tggtttaaaa aatggggccc      660

atactagtct tgcttgtttt actttcgctt ttggaaccgg gttctgccaa ttacgatcca      720

tgtctagact tcgacccaga aaactgcaca cttacttttg cacccgacac aagccgcatc      780

tgtggagttc atcgcctctc ttacgaactt ggcccccaac gacaaaaatt tacctgcatg      840

gtgggaatca accccatagt tatcacccag caaagtggag atactaaggg ttgcattcac      900

tgctcctgcg attccatcga gtgcacctac accctgctga agaccctatg cggcctaaga      960

gacctgctac caatgaatta a                                                981


<210>  20
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Sequence comprising a start codon


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  R is adenine or guanine

<400>  20
gccgccrcca ugg                                                          13


<210>  21
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  High efficiency self-cleavable E2A peptide sequence

<400>  21

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-myc tag

<400>  22

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-myc tag with amino acid spacer at the N and C terminal

<400>  23

Gly Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
1               5                   10              


<210>  24
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer - c-myc tag -spacer PDGF TM domain

<400>  24

Gly Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Ala Val Gly 
1               5                   10                  15      


Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu Pro Phe Lys 
            20                  25                  30          


Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu Thr Ile Ile 
        35                  40                  45              


Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro Arg 
    50                  55                  60          


<210>  25
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G4S linker

<400>  25

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  26
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDGFR Receptor A amino acid sequence

<400>  26

Ala Val Leu Val Leu Leu Val Ile Val Ile Ile Ser Leu Ile Val Leu 
1               5                   10                  15      


Val Val Ile Trp 
            20  


<210>  27
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PDGFR Receptor B amino acid sequence

<400>  27

Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu Thr Ile Ile Ser 
1               5                   10                  15      


Leu Ile Ile Leu Ile 
            20      


<210>  28
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insulin-like Growth Factor 1 amino acid sequence

<400>  28

Ile Ile Ile Gly Pro Pro Leu Ile Phe Val Phe Leu Phe Ser Val Val 
1               5                   10                  15      


Ile Gly Ser Ile Tyr Leu Phe Leu 
            20                  


<210>  29
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL6-R amino acid sequence

<400>  29

Ser Ser Ser Val Pro Leu Pro Thr Phe Leu Val Ala Gly Gly Ser Leu 
1               5                   10                  15      


Ala Phe Gly Thr Leu Leu Cys Ile Ala Ile Val Leu 
            20                  25              


<210>  30
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 amino acid sequence

<400>  30

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker

<400>  31

Asp Lys Thr His Thr Cys Ala Ala 
1               5               


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker

<400>  32

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10      


<210>  33
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker

<400>  33

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala 
        


<210>  34
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker

<400>  34

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Thr Cys Pro Pro Cys Pro Ala 
            20                  25  


<210>  35

<400>  35
000

<210>  36
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker

<400>  36

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Gly Lys Pro Thr His 
1               5                   10                  15      


Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr 
            20                  25                  30      


<210>  37
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker

<400>  37

Asp Lys Thr His Thr Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15  


<210>  38
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker

<400>  38

Asp Lys Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
1               5                   10                  15      


Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala 
            20                  25      


<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge linker

<400>  39

Asp Lys Thr His Thr Cys Pro Ser Cys Pro Ala 
1               5                   10      


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  40

Ser Gly Gly Gly Gly Ser Glu 
1               5           


<210>  41
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  41

Asp Lys Thr His Thr Ser 
1               5       


<210>  42
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  42

Ser Gly Gly Gly Gly Ser 
1               5       


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  43

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10      


<210>  44
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  44

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  45
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  45

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser 
            20      


<210>  46
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  46

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25      


<210>  47
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  47

Ala Ala Ala Gly Ser Gly Gly Ala Ser Ala Ser 
1               5                   10      


<210>  48
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  48

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Gly Ala Ser Ala Ser 
1               5                   10                  15      


<210>  49
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  49

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
1               5                   10                  15      


Gly Ala Ser Ala Ser 
            20      


<210>  50
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  50

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
1               5                   10                  15      


Xaa Gly Gly Gly Ser Gly Ala Ser Ala Ser 
            20                  25      


<210>  51
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<400>  51

Ala Ala Ala Gly Ser Gly Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser 
1               5                   10                  15      


Xaa Gly Gly Gly Ser Xaa Gly Gly Gly Ser Gly Ala Ser Ala Ser 
            20                  25                  30      


<210>  52
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  52

Ala Ala Ala Gly Ser Gly Xaa Ser Gly Ala Ser Ala Ser 
1               5                   10              


<210>  53
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  53

Pro Gly Gly Asn Arg Gly Thr Thr Thr Thr Arg Arg Pro Ala Thr Thr 
1               5                   10                  15      


Thr Gly Ser Ser Pro Gly Pro Thr Gln Ser His Tyr 
            20                  25              


<210>  54
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  54

Ala Thr Thr Thr Gly Ser Ser Pro Gly Pro Thr 
1               5                   10      


<210>  55
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  55

Ala Thr Thr Thr Gly Ser 
1               5       


<210>  56

<400>  56
000

<210>  57
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  57

Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Ser Pro Pro Ser Lys Glu 
1               5                   10                  15      


Ser His Lys Ser Pro 
            20      


<210>  58
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  58

Gly Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
1               5                   10                  15  


<210>  59
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  59

Gly Gly Gly Gly Ile Ala Pro Ser Met Val Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  60
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  60

Gly Gly Gly Gly Lys Val Glu Gly Ala Gly Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  61
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  61

Gly Gly Gly Gly Ser Met Lys Ser His Asp Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  62
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  62

Gly Gly Gly Gly Asn Leu Ile Thr Ile Val Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  63
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  63

Gly Gly Gly Gly Val Val Pro Ser Leu Pro Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  64
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  64

Gly Gly Glu Lys Ser Ile Pro Gly Gly Gly Gly Ser 
1               5                   10          


<210>  65
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  65

Arg Pro Leu Ser Tyr Arg Pro Pro Phe Pro Phe Gly Phe Pro Ser Val 
1               5                   10                  15      


Arg Pro 
        


<210>  66
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  66

Tyr Pro Arg Ser Ile Tyr Ile Arg Arg Arg His Pro Ser Pro Ser Leu 
1               5                   10                  15      


Thr Thr 
        


<210>  67
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  67

Thr Pro Ser His Leu Ser His Ile Leu Pro Ser Phe Gly Leu Pro Thr 
1               5                   10                  15      


Phe Asn 
        


<210>  68
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  68

Arg Pro Val Ser Pro Phe Thr Phe Pro Arg Leu Ser Asn Ser Trp Leu 
1               5                   10                  15      


Pro Ala 
        


<210>  69
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  69

Ser Pro Ala Ala His Phe Pro Arg Ser Ile Pro Arg Pro Gly Pro Ile 
1               5                   10                  15      


Arg Thr 
        


<210>  70
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  70

Ala Pro Gly Pro Ser Ala Pro Ser His Arg Ser Leu Pro Ser Arg Ala 
1               5                   10                  15      


Phe Gly 
        


<210>  71
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  71

Pro Arg Asn Ser Ile His Phe Leu His Pro Leu Leu Val Ala Pro Leu 
1               5                   10                  15      


Gly Ala 
        


<210>  72
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  72

Met Pro Ser Leu Ser Gly Val Leu Gln Val Arg Tyr Leu Ser Pro Pro 
1               5                   10                  15      


Asp Leu 
        


<210>  73
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  73

Ser Pro Gln Tyr Pro Ser Pro Leu Thr Leu Thr Leu Pro Pro His Pro 
1               5                   10                  15      


Ser Leu 
        


<210>  74
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  74

Asn Pro Ser Leu Asn Pro Pro Ser Tyr Leu His Arg Ala Pro Ser Arg 
1               5                   10                  15      


Ile Ser 
        


<210>  75
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  75

Leu Pro Trp Arg Thr Ser Leu Leu Pro Ser Leu Pro Leu Arg Arg Arg 
1               5                   10                  15      


Pro 
    


<210>  76
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  76

Pro Pro Leu Phe Ala Lys Gly Pro Val Gly Leu Leu Ser Arg Ser Phe 
1               5                   10                  15      


Pro Pro 
        


<210>  77
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  77

Val Pro Pro Ala Pro Val Val Ser Leu Arg Ser Ala His Ala Arg Pro 
1               5                   10                  15      


Pro Tyr 
        


<210>  78
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  78

Leu Arg Pro Thr Pro Pro Arg Val Arg Ser Tyr Thr Cys Cys Pro Thr 
1               5                   10                  15      


Pro 
    


<210>  79
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  79

Pro Asn Val Ala His Val Leu Pro Leu Leu Thr Val Pro Trp Asp Asn 
1               5                   10                  15      


Leu Arg 
        


<210>  80
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  80

Cys Asn Pro Leu Leu Pro Leu Cys Ala Arg Ser Pro Ala Val Arg Thr 
1               5                   10                  15      


Phe Pro 
        


<210>  81
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rigid linker

<400>  81

Gly Ala Pro Ala Pro Ala Ala Pro Ala Pro Ala 
1               5                   10      


<210>  82
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rigid Linker

<400>  82

Pro Pro Pro Pro 
1               


<210>  83

<400>  83
000

<210>  84
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  84

Asp Leu Cys Leu Arg Asp Trp Gly Cys Leu Trp 
1               5                   10      


<210>  85
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  85

Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10      


<210>  86
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  86

Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Gly Asp 
1               5                   10                  15  


<210>  87
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  87

Gln Arg Leu Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Glu Asp Asp Glu 
            20  


<210>  88
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  88

Gln Gly Leu Ile Gly Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Arg Ser Val 
            20  


<210>  89
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  89

Gln Gly Leu Ile Gly Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Arg Ser Val Lys 
            20      


<210>  90
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  90

Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp Asp 
1               5                   10                  15  


<210>  91
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  91

Arg Leu Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp 
        


<210>  92
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  92

Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp Asp 
1               5                   10                  15      


<210>  93
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  93

Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp 
1               5                   10                  15  


<210>  94
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  94

Arg Leu Met Glu Asp Ile Cys Leu Ala Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp 
        


<210>  95
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  95

Glu Val Arg Ser Phe Cys Thr Arg Trp Pro Ala Glu Lys Ser Cys Lys 
1               5                   10                  15      


Pro Leu Arg Gly 
            20  


<210>  96
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  96

Arg Ala Pro Glu Ser Phe Val Cys Tyr Trp Glu Thr Ile Cys Phe Glu 
1               5                   10                  15      


Arg Ser Glu Gln 
            20  


<210>  97
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  97

Glu Met Cys Tyr Phe Pro Gly Ile Cys Trp Met 
1               5                   10      


<210>  98
<211>  201
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Non-coding sequence suitable for inclusion into Bx

<400>  98
aaaatgatta ataaaaaatc acttacttga aatcagcaat aaggtctctg ttgaaatttt       60

ctcccagcag cacctcactt ccctcttccc aactctggta ttctaaaccc cgttcagcgg      120

catactttct ccatacttta aaggggatgt caaattttag ctcctctcct gtacccacaa      180

tcttcatgtc tttcttccca g                                                201


<210>  99
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Non-coding sequence suitable for inclusion into By

<400>  99
caaataaagt ttaacttgtt tatttgaaaa tcaa                                   34


<210>  100
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Restriction site cut by I-CreI

<400>  100
caaaacgtcg tgagacagtt tg                                                22


<210>  101
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Restriction site cut by I-CeuI

<400>  101
taactataac ggtcctaagg tagcgaa                                           27


<210>  102
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Restriction site cut by I-SceI

<400>  102
tagggataac agggtaat                                                     18


<210>  103
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  High efficiency self-cleavable F2A peptide sequence

<400>  103

Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210>  104
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader sequence

<400>  104

Val His Ser Ser 
1               


