               SEQUENCE LISTING

<110> Roche Diagnostics GmbH
      F. Hoffmann-La Roche AG
      Chugai Seiyaku Kabushiki Kaisha

<120> Novel anti-pY513-DDR1 antibodies 

<130> Y3137 PCT S3

<150> EP 16 19 7002.5
<151> 2016-11-03

<160> 55

<170> BiSSAP 1.2

<210> 1
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR(LC)1 (variant 1)

<400> 1
Gln Ala Ser Gln Ser Val Tyr Asn Asn Gly Phe Leu Ser 
1               5                   10              

<210> 2
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR(LC)1 (variant 2)

<400> 2
Gln Ala Ser Gln Ser Val His Asn Asn Asn Phe Leu Ser 
1               5                   10              

<210> 3
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR(LC)1 (variant 3)

<400> 3
Gln Ala Ser Gln Ser Ile Arg Thr Tyr Leu Ala 
1               5                   10      

<210> 4
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Immunogen DDR1_HUMAN(501-518)[pY513]

<220> 
<221> VARIANT
<222> 2
<223> beta-alanin

<220> 
<221> VARIANT
<222> 3
<223> amino caproic acid

<220> 
<221> VARIANT
<222> 4
<223> beta alanine

<220> 
<221> VARIANT
<222> 17
<223> phospho-tyrosine

<400> 4
Cys Xaa Xaa Xaa Pro Asn Gly Ser Ala Leu Leu Leu Ser Asn Pro Ala 
1               5                   10                  15      
Xaa Arg Leu Leu Leu Ala 
            20          

<210> 5
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR(LC)2 (variant 1)

<400> 5
Glu Ala Ser Lys Leu Ala Ser 
1               5           

<210> 6
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR(LC)2 (variant 2)

<400> 6
Arg Thr Ser Thr Leu Ala Ser 
1               5           

<210> 7
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Immunogen DDR1_HUMAN(509-526)[pY513]

<220> 
<221> VARIANT
<222> 5
<223> phospho-tyrosine

<220> 
<221> VARIANT
<222> 19
<223> beta alanine

<220> 
<221> VARIANT
<222> 20
<223> amino caproic acid

<220> 
<221> VARIANT
<222> 21
<223> beta alanine

<400> 7
Ser Asn Pro Ala Xaa Arg Leu Leu Leu Ala Thr Tyr Ala Arg Pro Pro 
1               5                   10                  15      
Arg Gly Xaa Xaa Xaa Cys 
            20          

<210> 8
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR(LC)3 (variant 1)

<400> 8
Gln Gly Phe Tyr Ser Asp Tyr Ile Tyr Pro 
1               5                   10  

<210> 9
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR(LC)3 (variant 2)

<400> 9
Gln Ser Tyr Tyr Phe Asp Ser Thr Thr Thr Tyr Gly Asn Thr 
1               5                   10                  

<210> 10
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Screening Peptide DDR1_HUMAN(506-520)[pTyr513]

<220> 
<221> VARIANT
<222> 8
<223> phospho-tyrosine

<220> 
<221> VARIANT
<222> 16
<223> glutamic acid modified with biotin via a PEG linker

<400> 10
Leu Leu Leu Ser Asn Pro Ala Xaa Arg Leu Leu Leu Ala Thr Tyr Xaa 
1               5                   10                  15      



<210> 11
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR(HC)1 (variant 1)

<400> 11
Thr Val Ser Gly Ile Asp Leu Ser Thr Tyr Pro Met Ser 
1               5                   10              

<210> 12
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR(HC)1 (variant 2)

<400> 12
Thr Ala Ser Gly Phe Thr Leu Ser Ser Tyr Trp Met Cys 
1               5                   10              

<210> 13
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Screening Peptide DDR1_HUMAN(501-526)[pY513]

<220> 
<221> VARIANT
<222> 1
<223> glutamic acid modified with biotin via a PEG linker

<220> 
<221> VARIANT
<222> 14
<223> phospho-tyrosine

<400> 13
Xaa Pro Asn Gly Ser Ala Leu Leu Leu Ser Asn Pro Ala Xaa Arg Leu 
1               5                   10                  15      
Leu Leu Ala Thr Tyr Ala Arg Pro Pro Arg Gly 
            20                  25          

<210> 14
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR(HC)2 (variant 1)

<400> 14
Ile Ile Gly Ser Thr Asp Asn Thr His Tyr Ala Asn Trp Ala Lys Gly 
1               5                   10                  15      



<210> 15
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR(HC)2 (variant 2)

<400> 15
Ile Ile Gly Ser Thr Gly Leu Thr His Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      



<210> 16
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR(HC)2 (variant 3)

<400> 16
Tyr Ile Tyr Thr Gly Ser Asp Ser Tyr Tyr Ala Thr Trp Ala Lys Gly 
1               5                   10                  15      



<210> 17
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Screening Peptide DDR1_HUMAN(501-526)

<220> 
<221> VARIANT
<222> 1
<223> glutamic acid modified with biotin via a PEG linker

<400> 17
Xaa Pro Asn Gly Ser Ala Leu Leu Leu Ser Asn Pro Ala Tyr Arg Leu 
1               5                   10                  15      
Leu Leu Ala Thr Tyr Ala Arg Pro Pro Arg Gly 
            20                  25          

<210> 18
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR(HC)3 (variant 1)

<400> 18
Ser Arg Ala Phe Gly Asn Ser Tyr Val Ser Val Thr Gly Asp Leu 
1               5                   10                  15  

<210> 19
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR(HC)3 (variant 2)

<400> 19
Ser Arg Ala Tyr Gly Ser Ser Tyr Val Ser Val Thr Gly Asp Leu 
1               5                   10                  15  

<210> 20
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR(HC)3 (variant 3)

<400> 20
Gly Gly Tyr Ser Tyr Gly Ala Gly Gly Val Gly Tyr Ala Ser Thr Arg 
1               5                   10                  15      
Leu Asp Leu 
            

<210> 21
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Screening Peptide DDR1_HUMAN(501-526)[pY513]

<220> 
<221> VARIANT
<222> 1
<223> glutamic acid modified with biotin via a PEG linker

<220> 
<221> VARIANT
<222> 14
<223> phospho-tyrosine

<400> 21
Xaa Pro Asn Gly Ser Ala Leu Leu Leu Ser Asn Pro Ala Xaa Arg Leu 
1               5                   10                  15      
Leu Leu Ala Thr Tyr Ala Arg Pro Pro Arg Gly 
            20                  25          

<210> 22
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> FW(LC)1 (variant 1)

<400> 22
Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly Gly 
1               5                   10                  15      
Thr Val Thr Ile Asn Cys 
            20          

<210> 23
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> FW(LC)2 (variant 1)

<400> 23
Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 24
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> FW(LC)3 (variant 1)

<400> 24
Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          



<210> 25
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> FW(LC)4 (variant 1)

<400> 25
Phe Gly Gly Gly Thr Glu Val Val Val Lys 
1               5                   10  

<210> 26
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> FW(LC)1 (variant 2)

<400> 26
Arg Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly Gly 
1               5                   10                  15      
Thr Val Thr Ile Ser Cys 
            20          

<210> 27
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> FW(LC)2 (variant 2)

<400> 27
Trp Tyr Gln Lys Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  

<210> 28
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> FW(LC)3 (variant 2)

<400> 28
Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          



<210> 29
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> FW(LC)1 (variant 3)

<400> 29
Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      
Gly Thr Val Thr Ile Asn Cys 
            20              

<210> 30
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> FW(LC)2 (variant 3)

<400> 30
Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile His 
1               5                   10                  15  

<210> 31
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> FW(LC)3 (variant 3)

<400> 31
Gly Val Pro Ser Arg Phe Lys Gly Gly Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      
Leu Thr Ile Ser Asp Leu Ala Cys Ala Asp Ala Ala Ala Tyr Tyr Cys 
            20                  25                  30          



<210> 32
<211> 236
<212> PRT
<213> Artificial Sequence

<220> 
<223> full length light chain (variant 6G9)

<400> 32
Met Asp Met Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      
Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Pro Ser Pro 
            20                  25                  30          
Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser 
        35                  40                  45              
Gln Ser Val Tyr Asn Asn Gly Phe Leu Ser Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  
Gly Gln Pro Pro Lys Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser 
65                  70                  75                  80  
Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr 
                85                  90                  95      
Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         
Gln Gly Phe Tyr Ser Asp Tyr Ile Tyr Pro Phe Gly Gly Gly Thr Glu 
        115                 120                 125             
Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro 
    130                 135                 140                 
Pro Ala Ala Asp Gln Val Ala Thr Gly Thr Val Thr Ile Val Cys Val 
145                 150                 155                 160 
Ala Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly 
                165                 170                 175     
Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser 
            180                 185                 190         
Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr 
        195                 200                 205             
Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr 
    210                 215                 220                 
Thr Ser Val Val Gln Ser Phe Asn Arg Gly Asp Cys 
225                 230                 235     

<210> 33
<211> 462
<212> PRT
<213> Artificial Sequence

<220> 
<223> full length heavy chain (variant 6G9)

<400> 33
Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          
Gly Gly Ser Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser 
        35                  40                  45              
Thr Tyr Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  
Trp Ile Gly Ile Ile Gly Ser Thr Asp Asn Thr His Tyr Ala Asn Trp 
65                  70                  75                  80  
Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu 
                85                  90                  95      
Lys Val Ala Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
            100                 105                 110         
Arg Ser Arg Ala Phe Gly Asn Ser Tyr Val Ser Val Thr Gly Asp Leu 
        115                 120                 125             
Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gln Pro Lys Ala 
    130                 135                 140                 
Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser 
145                 150                 155                 160 
Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Leu Pro Glu Pro Val 
                165                 170                 175     
Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn Gly Val Arg Thr Phe 
            180                 185                 190         
Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             
Ser Val Thr Ser Ser Gly Gln Pro Val Thr Cys Asn Val Ala His Pro 
    210                 215                 220                 
Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala Pro Ser Thr Cys Ser 
225                 230                 235                 240 
Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     
Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         
Glu Val Thr Cys Val Val Val Asp Val Ser Gln Asp Asp Pro Glu Val 
        275                 280                 285             
Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val Arg Thr Ala Arg Pro 
    290                 295                 300                 
Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile Arg Val Val Ser Thr 
305                 310                 315                 320 
Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys 
                325                 330                 335     
Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         
Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val Tyr Thr Met Gly Pro 
        355                 360                 365             
Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser Leu Thr Cys Met Ile 
    370                 375                 380                 
Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Lys Asn Gly 
385                 390                 395                 400 
Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser Asp 
                405                 410                 415     
Gly Ser Tyr Phe Leu Tyr Asn Lys Leu Ser Val Pro Thr Ser Glu Trp 
            420                 425                 430         
Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             
Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser Pro Gly Lys 
    450                 455                 460         

<210> 34
<211> 236
<212> PRT
<213> Artificial Sequence

<220> 
<223> full length light chain (variant 10A10)

<400> 34
Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      
Leu Pro Gly Ala Thr Phe Ala Arg Val Leu Thr Gln Thr Pro Ser Pro 
            20                  25                  30          
Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Ser Cys Gln Ala Ser 
        35                  40                  45              
Gln Ser Val His Asn Asn Asn Phe Leu Ser Trp Tyr Gln Lys Lys Pro 
    50                  55                  60                  
Gly Gln Pro Pro Lys Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser 
65                  70                  75                  80  
Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      
Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         
Gln Gly Phe Tyr Ser Asp Tyr Ile Tyr Pro Phe Gly Gly Gly Thr Glu 
        115                 120                 125             
Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro 
    130                 135                 140                 
Pro Ala Ala Asp Gln Val Ala Thr Gly Thr Val Thr Ile Val Cys Val 
145                 150                 155                 160 
Ala Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly 
                165                 170                 175     
Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser 
            180                 185                 190         
Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr 
        195                 200                 205             
Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr 
    210                 215                 220                 
Thr Ser Val Val Gln Ser Phe Asn Arg Gly Asp Cys 
225                 230                 235     

<210> 35
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> FW(HC)1 (variant 1)

<400> 35
Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly Ser 
1               5                   10                  15      
Leu Thr Leu Thr Cys 
            20      

<210> 36
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> FW(HC)2 (variant 1)

<400> 36
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  

<210> 37
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> FW(HC)3 (variant 1)

<400> 37
Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Val Ala 
1               5                   10                  15      
Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  

<210> 38
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> FW(HC)4 (variant 1)

<400> 38
Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

<210> 39
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> FW(HC)1 (variant 2)

<400> 39
Gln Ser Val Glu Glu Ser Gly Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      
Leu Thr Leu Thr Cys 
            20      

<210> 40
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> FW(HC)2 (variant 2)

<400> 40
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
1               5                   10                  

<210> 41
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> FW(HC)3 (variant 2)

<400> 41
Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
1               5                   10                  15      
Ser Pro Thr Thr Glu Asp Thr Ala Ala Tyr Phe Cys Ala Arg 
            20                  25                  30  

<210> 42
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> FW(HC)4 (variant 2)

<400> 42
Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

<210> 43
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> FW(HC)1 (variant 3)

<400> 43
Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      
Leu Thr Leu Thr Cys 
            20      

<210> 44
<211> 31
<212> PRT
<213> Artificial Sequence

<220> 
<223> FW(HC)3 (variant 3)

<400> 44
Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Ala Val Thr Leu Gln Met 
1               5                   10                  15      
Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30      

<210> 45
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> FW(HC)4 (variant 3)

<400> 45
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      

<210> 46
<211> 462
<212> PRT
<213> Artificial Sequence

<220> 
<223> full length heavy chain (variant 10A10)

<400> 46
Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      
Gly Gln Cys Gln Ser Val Glu Glu Ser Gly Gly Gly Leu Phe Lys Pro 
            20                  25                  30          
Thr Asp Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser 
        35                  40                  45              
Thr Tyr Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  
Tyr Ile Gly Ile Ile Gly Ser Thr Gly Leu Thr His Tyr Ala Ser Trp 
65                  70                  75                  80  
Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu 
                85                  90                  95      
Lys Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Ala Tyr Phe Cys Ala 
            100                 105                 110         
Arg Ser Arg Ala Tyr Gly Ser Ser Tyr Val Ser Val Thr Gly Asp Leu 
        115                 120                 125             
Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gln Pro Lys Ala 
    130                 135                 140                 
Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser 
145                 150                 155                 160 
Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Leu Pro Glu Pro Val 
                165                 170                 175     
Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn Gly Val Arg Thr Phe 
            180                 185                 190         
Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             
Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys Asn Ala Ala His Pro 
    210                 215                 220                 
Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala Pro Ser Thr Cys Ser 
225                 230                 235                 240 
Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     
Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         
Glu Val Thr Cys Val Val Val Asp Val Ser Gln Asp Asp Pro Glu Val 
        275                 280                 285             
Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val Arg Thr Ala Arg Pro 
    290                 295                 300                 
Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile Arg Val Val Ser Thr 
305                 310                 315                 320 
Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys 
                325                 330                 335     
Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         
Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val Tyr Thr Met Gly Pro 
        355                 360                 365             
Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser Leu Thr Cys Met Ile 
    370                 375                 380                 
Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Lys Asn Gly 
385                 390                 395                 400 
Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser Asp 
                405                 410                 415     
Gly Ser Tyr Phe Leu Tyr Asn Lys Leu Ser Val Pro Thr Ser Glu Trp 
            420                 425                 430         
Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             
Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser Pro Gly Lys 
    450                 455                 460         

<210> 47
<211> 239
<212> PRT
<213> Artificial Sequence

<220> 
<223> full length light chain (variant 16B8)

<400> 47
Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      
Leu Pro Gly Ala Arg Cys Ala Asp Ile Val Met Thr Gln Thr Pro Ala 
            20                  25                  30          
Ser Val Glu Ala Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala 
        35                  40                  45              
Ser Gln Ser Ile Arg Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  
Gln Pro Pro Lys Leu Leu Ile His Arg Thr Ser Thr Leu Ala Ser Gly 
65                  70                  75                  80  
Val Pro Ser Arg Phe Lys Gly Gly Gly Ser Gly Thr Gln Phe Thr Leu 
                85                  90                  95      
Thr Ile Ser Asp Leu Ala Cys Ala Asp Ala Ala Ala Tyr Tyr Cys Gln 
            100                 105                 110         
Ser Tyr Tyr Phe Asp Ser Thr Thr Thr Tyr Gly Asn Thr Phe Gly Gly 
        115                 120                 125             
Gly Thr Glu Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu 
    130                 135                 140                 
Ile Phe Pro Pro Ala Ala Asp Gln Val Ala Thr Gly Thr Val Thr Ile 
145                 150                 155                 160 
Val Cys Val Ala Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu 
                165                 170                 175     
Val Asp Gly Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro 
            180                 185                 190         
Gln Asn Ser Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu 
        195                 200                 205             
Thr Ser Thr Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr 
    210                 215                 220                 
Gln Gly Thr Thr Ser Val Val Gln Ser Phe Asn Arg Gly Asp Cys 
225                 230                 235                 

<210> 48
<211> 467
<212> PRT
<213> Artificial Sequence

<220> 
<223> full length heavy chain (variant 16B8)

<400> 48
Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      
Val Gln Cys Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro 
            20                  25                  30          
Gly Ala Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Thr Leu Ser 
        35                  40                  45              
Ser Tyr Trp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  
Trp Ile Gly Tyr Ile Tyr Thr Gly Ser Asp Ser Tyr Tyr Ala Thr Trp 
65                  70                  75                  80  
Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Ala Val Thr 
                85                  90                  95      
Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
            100                 105                 110         
Ala Arg Gly Gly Tyr Ser Tyr Gly Ala Gly Gly Val Gly Tyr Ala Ser 
        115                 120                 125             
Thr Arg Leu Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 
Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly 
145                 150                 155                 160 
Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
                165                 170                 175     
Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn 
            180                 185                 190         
Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             
Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys 
    210                 215                 220                 
Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala 
225                 230                 235                 240 
Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly 
                245                 250                 255     
Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
        275                 280                 285             
Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val 
    290                 295                 300                 
Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile 
305                 310                 315                 320 
Arg Val Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly 
                325                 330                 335     
Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         
Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val 
        355                 360                 365             
Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser 
    370                 375                 380                 
Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu 
385                 390                 395                 400 
Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala 
                405                 410                 415     
Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Asn Lys Leu Ser Val 
            420                 425                 430         
Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met 
        435                 440                 445             
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser 
    450                 455                 460                 
Pro Gly Lys 
465         

<210> 49
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> light chain variable domain (variant 6G9)

<400> 49
Gln Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly Gly 
1               5                   10                  15      
Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr Asn Asn Gly 
            20                  25                  30          
Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Gln 
65                  70                  75                  80  
Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Phe Tyr Ser Asp Tyr 
                85                  90                  95      
Ile Tyr Pro Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 

<210> 50
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> heavy chain variable domain (variant 6G9)

<400> 50
Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly Ser 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Thr Tyr Pro 
            20                  25                  30          
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              
Ile Ile Gly Ser Thr Asp Asn Thr His Tyr Ala Asn Trp Ala Lys Gly 
    50                  55                  60                  
Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Val Ala 
65                  70                  75                  80  
Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ser Arg 
                85                  90                  95      
Ala Phe Gly Asn Ser Tyr Val Ser Val Thr Gly Asp Leu Trp Gly Pro 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 

<210> 51
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> light chain variable domain (variant 10A10)

<400> 51
Arg Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly Gly 
1               5                   10                  15      
Thr Val Thr Ile Ser Cys Gln Ala Ser Gln Ser Val His Asn Asn Asn 
            20                  25                  30          
Phe Leu Ser Trp Tyr Gln Lys Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Gln 
65                  70                  75                  80  
Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Phe Tyr Ser Asp Tyr 
                85                  90                  95      
Ile Tyr Pro Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 

<210> 52
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> heavy chain variable domain (variant 10A10)

<400> 52
Gln Ser Val Glu Glu Ser Gly Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Thr Tyr Pro 
            20                  25                  30          
Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              
Ile Ile Gly Ser Thr Gly Leu Thr His Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  
Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  
Ser Pro Thr Thr Glu Asp Thr Ala Ala Tyr Phe Cys Ala Arg Ser Arg 
                85                  90                  95      
Ala Tyr Gly Ser Ser Tyr Val Ser Val Thr Gly Asp Leu Trp Gly Pro 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 

<210> 53
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> light chain variable domain (variant 16B8)

<400> 53
Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      
Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Arg Thr Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              
His Arg Thr Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  
Gly Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Ala Cys 
65                  70                  75                  80  
Ala Asp Ala Ala Ala Tyr Tyr Cys Gln Ser Tyr Tyr Phe Asp Ser Thr 
                85                  90                  95      
Thr Thr Tyr Gly Asn Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         



<210> 54
<211> 125
<212> PRT
<213> Artificial Sequence

<220> 
<223> heavy chain variable domain (variant 16B8)

<400> 54
Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Thr Leu Ser Ser Tyr Trp 
            20                  25                  30          
Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              
Tyr Ile Tyr Thr Gly Ser Asp Ser Tyr Tyr Ala Thr Trp Ala Lys Gly 
    50                  55                  60                  
Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Ala Val Thr Leu Gln Met 
65                  70                  75                  80  
Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly 
                85                  90                  95      
Gly Tyr Ser Tyr Gly Ala Gly Gly Val Gly Tyr Ala Ser Thr Arg Leu 
            100                 105                 110         
Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 

<210> 55
<211> 913
<212> PRT
<213> Homo sapiens

<220> 
<223> DDR1_HUMAN Epithelial discoidin domain-containing receptor 1,
      Q08345

<400> 55
Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      
Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          
Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              
Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  
Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  
Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      
Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         
Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             
Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 
Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 
Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     
Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         
Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             
Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln 
    210                 215                 220                 
Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 
Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     
Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe 
            260                 265                 270         
Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn 
        275                 280                 285             
Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg 
    290                 295                 300                 
Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His 
305                 310                 315                 320 
Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val 
                325                 330                 335     
Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe 
            340                 345                 350         
Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val 
        355                 360                 365             
Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro 
    370                 375                 380                 
Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu 
385                 390                 395                 400 
Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr 
                405                 410                 415     
Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu 
            420                 425                 430         
Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser 
        435                 440                 445             
Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser 
    450                 455                 460                 
Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu 
465                 470                 475                 480 
Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro His Ser 
                485                 490                 495     
Ala Pro Cys Val Pro Asn Gly Ser Ala Leu Leu Leu Ser Asn Pro Ala 
            500                 505                 510         
Tyr Arg Leu Leu Leu Ala Thr Tyr Ala Arg Pro Pro Arg Gly Pro Gly 
        515                 520                 525             
Pro Pro Thr Pro Ala Trp Ala Lys Pro Thr Asn Thr Gln Ala Tyr Ser 
    530                 535                 540                 
Gly Asp Tyr Met Glu Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro 
545                 550                 555                 560 
Pro Pro Gln Asn Ser Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr 
                565                 570                 575     
Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro 
            580                 585                 590         
Pro Gly Ala Val Gly Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser 
        595                 600                 605             
Arg Leu Arg Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val 
    610                 615                 620                 
His Leu Cys Glu Val Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Phe 
625                 630                 635                 640 
Pro Leu Asn Val Arg Lys Gly His Pro Leu Leu Val Ala Val Lys Ile 
                645                 650                 655     
Leu Arg Pro Asp Ala Thr Lys Asn Ala Arg Asn Asp Phe Leu Lys Glu 
            660                 665                 670         
Val Lys Ile Met Ser Arg Leu Lys Asp Pro Asn Ile Ile Arg Leu Leu 
        675                 680                 685             
Gly Val Cys Val Gln Asp Asp Pro Leu Cys Met Ile Thr Asp Tyr Met 
    690                 695                 700                 
Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser Ala His Gln Leu Glu Asp 
705                 710                 715                 720 
Lys Ala Ala Glu Gly Ala Pro Gly Asp Gly Gln Ala Ala Gln Gly Pro 
                725                 730                 735     
Thr Ile Ser Tyr Pro Met Leu Leu His Val Ala Ala Gln Ile Ala Ser 
            740                 745                 750         
Gly Met Arg Tyr Leu Ala Thr Leu Asn Phe Val His Arg Asp Leu Ala 
        755                 760                 765             
Thr Arg Asn Cys Leu Val Gly Glu Asn Phe Thr Ile Lys Ile Ala Asp 
    770                 775                 780                 
Phe Gly Met Ser Arg Asn Leu Tyr Ala Gly Asp Tyr Tyr Arg Val Gln 
785                 790                 795                 800 
Gly Arg Ala Val Leu Pro Ile Arg Trp Met Ala Trp Glu Cys Ile Leu 
                805                 810                 815     
Met Gly Lys Phe Thr Thr Ala Ser Asp Val Trp Ala Phe Gly Val Thr 
            820                 825                 830         
Leu Trp Glu Val Leu Met Leu Cys Arg Ala Gln Pro Phe Gly Gln Leu 
        835                 840                 845             
Thr Asp Glu Gln Val Ile Glu Asn Ala Gly Glu Phe Phe Arg Asp Gln 
    850                 855                 860                 
Gly Arg Gln Val Tyr Leu Ser Arg Pro Pro Ala Cys Pro Gln Gly Leu 
865                 870                 875                 880 
Tyr Glu Leu Met Leu Arg Cys Trp Ser Arg Glu Ser Glu Gln Arg Pro 
                885                 890                 895     
Pro Phe Ser Gln Leu His Arg Phe Leu Ala Glu Asp Ala Leu Asn Thr 
            900                 905                 910         
Val 
    

